CN111643723B - Liquid dressing containing icodextrin - Google Patents
Liquid dressing containing icodextrin Download PDFInfo
- Publication number
- CN111643723B CN111643723B CN202010604207.5A CN202010604207A CN111643723B CN 111643723 B CN111643723 B CN 111643723B CN 202010604207 A CN202010604207 A CN 202010604207A CN 111643723 B CN111643723 B CN 111643723B
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- Prior art keywords
- icodextrin
- dressing
- liquid dressing
- containing liquid
- parts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0076—Sprayable compositions
Abstract
The invention provides a liquid dressing containing icodextrin, which takes purified water or water for injection as a carrier, is added with icodextrin, polyhydric alcohol, a preservative and a thickening agent, and can be prepared into a spray or essence liquid form.
Description
Technical Field
The invention belongs to the field of medical instruments, and particularly relates to a liquid dressing containing icodextrin.
Background
The dressing generally refers to an external material with the functions of protecting wounds and preventing secondary infection, heat loss and the like in the medical field, and at present, gauze traditional dressings and modern dressings are mainly used, and the modern dressings include sodium alginate/calcium dressings, interactive dressings, silver ion dressings, foam dressings, gel dressings and the like.
The glucan is homotypic polysaccharide composed of glucose as monosaccharide, and is divided into alpha-glucan and beta-glucan, and each glucan is combined by multiple bond positions. Dextran has a long history in the western world as an active ingredient in skin care products. Families in many European and American countries are used to bath the infants with water soaked with oat to relieve and prevent eczema; the elderly are also used to wash their face with oat water in winter to relieve dry skin. This is mainly due to the fact that the substances extracted from oats contain vitamin E and glucan components, both of which have a certain repairing and protecting effect on the skin.
The alpha-glucan oligosaccharide is a product obtained by acting glucose transferase on maltose, the polymerization degree of the alpha-glucan oligosaccharide is 4-6 glucose units, the molecular weight of the alpha-glucan oligosaccharide is small, and the alpha-glucan oligosaccharide is mainly used for moisturizing. However, the alpha-glucan oligosaccharide has a small molecular weight, cannot form an effective protective film on the skin surface, and has a weak protective effect.
Icodextrin is dextran prepared by hydrolyzing starch, has molecular weight of 19000-25000 dalton, and has good water solubility, safety and biocompatibility. The pharmaceutical preparation taking the icodextrin as the raw material is approved to be on the market in more than 30 countries and regions, and has good safety, biocompatibility and stability; the colloidal solution prepared from the icodextrin has good ultrafiltration effect and hydration floating effect, can be used as peritoneal dialysis solution and surgical anti-adhesion flushing solution, and Cooker shows that the icodextrin has good biocompatibility in a paper published in 2002; the paper published by Mistry in 1994 shows that icodextrin solutions proved safe and effective for long-term use as peritoneal dialysis solutions in a randomized multicenter clinical trial; the patent paper published by Catena in 2012 indicated that in a single-center, prospective randomized trial, the use of 4% icodextrin was safe in patients with small intestinal obstruction, reducing the risk of intra-abdominal adhesions forming and reoccluding.
In the process of studying icodextrin, we find that the colloidal solution formed by icodextrin has the efficacy of protection, which is probably because the icodextrin solution is the colloidal solution, an effective protective film can be formed on the surface of skin, the external pollution and the invasion of harmful bacteria are prevented, and a better protective effect is achieved on the affected part.
Disclosure of Invention
The invention aims to provide a strong and effective non-sterile dressing which can effectively form a film in organisms, and has high stability, high safety and strong biocompatibility.
A liquid dressing containing icodextrin, characterized in that: the dressing comprises the following components in parts by mass:
89-95 parts of purified water or water for injection, 2.4-3.7 parts of icodextrin, 1.8-5 parts of polyalcohol, 0.5-1.5 parts of preservative and 0.2-0.9 part of thickening agent.
The liquid dressing containing the icodextrin specifically comprises the following components in parts by mass:
92 parts of purified water or water for injection, 3 parts of icodextrin, 4 parts of polyhydric alcohol, 0.5 part of preservative and 0.5 part of thickening agent.
The liquid dressing containing icodextrin is in a liquid state.
The liquid dressing containing icodextrin is in a spraying state.
A liquid dressing comprising icodextrin, said polyhydric alcohol being selected from the group consisting of 1, 2-hexanediol, ethylene glycol, propylene glycol, butylene glycol, pentanediol, dipropylene glycol, neopentyl glycol, ethanol, dipropylene glycol, hydroxyethyl urea, methyl propylene glycol.
The butanediol is chiral asymmetric 1, 3-butanediol.
A liquid dressing containing icodextrin is prepared from phenoxyethanol, chlorphenesin, methyl hydroxybenzoate, propyl hydroxybenzoate, methylisothiazolinone, iodopropynyl butylcarbamate, DMDM hydantoin, and benzyl alcohol.
The antiseptic is phenoxyethanol.
The preservative is a mixture of phenoxyethanol and methyl hydroxybenzoate, and the mass ratio is 1-5: 5 to 1.
A liquid dressing containing icodextrin, wherein the thickening agent is selected from hydrolyzed sclerotium rolfsii gum, hydroxyethyl cellulose, acrylic acid (ester) copolymer, polyvinyl alcohol, polyethylene glycol-115M, acryloyl dimethyl ammonium taurate/VP copolymer and hydroxymethyl cellulose.
The thickening agent is hydrolyzed sclerotium rolfsii gum, and the best effect is achieved when the mass concentration of the thickening agent in the dressing is 0.5%.
The technical scheme disclosed by the invention has the following beneficial effects:
(1) protection function: the main component of the dressing provided by the invention is icodextrin, which can provide a protective barrier for skin, so that the skin can maintain a clean and healthy state, particularly when the dressing is used for a wound part, the damage of the external environment to a naked affected part can be reduced, a protective film can be formed on the surface of the wound, the wound is protected from being aggravated by external pollution or affected to heal, and the skin is helped to resist pollutants which are easy to cause scars.
(2) Repairing action: the liquid dressing containing the icodextrin can be directly used on a wound or a scar to form a film rapidly, accelerate the healing of the wound surface and absorb exudate on the surface of the wound rapidly. Can be used on wound to prevent infection, prevent pollution and provide clean and healthy recovery environment for wound, thereby preventing scar hyperplasia and reducing scar (especially color-deposition scar).
Detailed Description
The present invention will be further described with reference to the following detailed description, but the scope of the present invention is not limited to the description.
The liquid dressing containing the icodextrin is disclosed by the invention, but the liquid dressing containing the icodextrin disclosed by the invention can be produced by adopting all applicable processes and is not limited to the production processes described in the examples.
Example 1:
each 10kg of icodextrin dressing contained: 0.3kg of icodextrin, 9.2kg of purified water, 0.4kg of 1, 3-butanediol, 0.05kg of sclerotium rolfsii hydrolysis glue, 0.02kg of phenoxyethanol and 0.03kg of methylparaben.
The preparation process of the dressing is as follows: dissolving icodextrin, hydrolyzed sclerotium rolfsii gum, methyl hydroxybenzoate and 1, 3-butanediol in purified water, heating to 85 deg.C, stirring, keeping the temperature for 30min, cooling to below 45 deg.C, and adding phenoxyethanol. Standing and defoaming to obtain the icodextrin liquid dressing.
Example 2:
each 10kg of icodextrin dressing contained: 0.37kg of icodextrin, 9.0kg of purified water, 0.2kg of 1, 2-pentanediol, 0.3kg of 1, 3-propanediol, 0.06kg of polyethylene glycol-115M, 0.05kg of phenoxyethanol and 0.02kg of methylparaben.
The preparation process of the dressing is as follows: dissolving 1, 2-pentanediol and 1, 3-propanediol in purified water, adding icodextrin and polyethylene glycol-115M, uniformly stirring, heating to 36.5 ℃, adding phenoxyethanol and methyl hydroxybenzoate, uniformly stirring, standing and defoaming to obtain the icodextrin dressing (essence).
Example 3:
each 10kg of icodextrin dressing contained: icodextrin 0.25kg, purified water 9.4kg, 1, 2-propylene glycol 0.1kg, dipropylene glycol 0.1kg, ammonium acryloyldimethyl taurate/VP copolymer 0.05kg, DMDM hydantoin 0.1 kg.
The preparation process of the dressing is as follows: dissolving 1, 2-propylene glycol and dipropylene glycol in purified water, adding the icodextrin and the acryloyl dimethyl ammonium taurate/VP copolymer, uniformly stirring, heating to 35 ℃, adding the DMDM hydantoin, uniformly stirring, standing and defoaming to obtain the icodextrin liquid dressing.
The implementation effect is as follows:
(1) the dressings obtained in the above embodiments are sealed and kept still for one week at normal temperature and pressure after being sterilized at high temperature, the state of the auxiliary materials is observed every 6 hours, the obtained dressings are all stable, and no flocculation or caking occurs.
(2) The dressing obtained in the above example was applied or sprayed to superficial wounds (wounds were all 1 cm) on the right hind leg of a rat twice a day by taking 18 rats, and 3 groups of rats with wounds each containing 3 rats were taken as a control group by applying iodophors. The results of the experiments are shown in the following table:
the dressing has the advantages of good stability, mildness, no stimulation and good biological skin adaptability, can effectively and quickly promote wound healing, can form a protective film on the surface of a wound, protects the wound from being aggravated by external pollution or influences healing, and helps the skin to resist pollutants which are easy to cause scars.
The above examples describe specific embodiments of the present invention in detail, but the present invention is not limited to the above embodiments, and various changes can be made without departing from the gist of the present invention within the knowledge of those skilled in the art.
Claims (10)
1. A liquid dressing containing icodextrin, characterized in that: the dressing comprises the following components in parts by mass: 89-95 parts of purified water or water for injection, 2.4-3.7 parts of icodextrin, 1.8-5 parts of polyalcohol, 0.5-1.5 parts of preservative and 0.2-0.9 part of thickening agent.
2. The icodextrin-containing liquid dressing of claim 1, wherein: the dressing is in a liquid state.
3. The icodextrin-containing liquid dressing of claim 1, wherein: the dressing is in a spray state.
4. The icodextrin-containing liquid dressing of claim 1, wherein: the polyhydric alcohol is selected from 1, 2-hexanediol, ethylene glycol, propylene glycol, butylene glycol, pentanediol, dipropylene glycol, neopentyl glycol, ethanol, dipropylene glycol, hydroxyethyl urea, methyl propylene glycol.
5. The icodextrin-containing liquid dressing of claim 4, wherein: the butanediol is chiral asymmetric 1, 3-butanediol.
6. The icodextrin-containing liquid dressing of claim 1, wherein: the antiseptic is selected from phenoxyethanol, chlorphenesin, methyl hydroxybenzoate, propyl hydroxybenzoate, methylisothiazolinone, iodopropynyl butylcarbamate, DMDM hydantoin, and benzyl alcohol.
7. The icodextrin-containing liquid dressing of claim 1, wherein: the preservative is phenoxyethanol.
8. The icodextrin-containing liquid dressing of claim 1, wherein: the preservative is a mixture of phenoxyethanol and methyl hydroxybenzoate, and the mass ratio is 1-5: 5 to 1.
9. The icodextrin-containing liquid dressing of claim 1, wherein: the thickening agent is selected from hydrolyzed sclerotium rolfsii gum, hydroxyethyl cellulose, acrylic copolymer, polyvinyl alcohol, polyethylene glycol-115M, acryloyl dimethyl ammonium taurate/VP copolymer and hydroxymethyl cellulose.
10. The icodextrin-containing liquid dressing of claim 1, wherein: the thickening agent is hydrolyzed sclerotium rolfsii gum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010604207.5A CN111643723B (en) | 2020-06-29 | 2020-06-29 | Liquid dressing containing icodextrin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010604207.5A CN111643723B (en) | 2020-06-29 | 2020-06-29 | Liquid dressing containing icodextrin |
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| Publication Number | Publication Date |
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| CN111643723A CN111643723A (en) | 2020-09-11 |
| CN111643723B true CN111643723B (en) | 2022-04-19 |
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| CN202010604207.5A Active CN111643723B (en) | 2020-06-29 | 2020-06-29 | Liquid dressing containing icodextrin |
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| CN112245346A (en) * | 2020-09-30 | 2021-01-22 | 华仁健康产业(青岛)有限公司 | Moisture mask and preparation method thereof |
| CN112263509A (en) * | 2020-09-30 | 2021-01-26 | 华仁健康产业(青岛)有限公司 | Sleep mask and preparation method thereof |
Citations (2)
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| CN105536027A (en) * | 2015-12-24 | 2016-05-04 | 南阳市汇博生物技术有限公司 | Scar treatment strip capable of lowering tissue tension and preparation method thereof |
| CN105769698A (en) * | 2016-04-14 | 2016-07-20 | 曼秀雷敦(中国)药业有限公司 | Cosmetic composition without preservative and application of cosmetic composition |
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| CN105056237B (en) * | 2012-08-01 | 2020-11-10 | 南京神奇科技开发有限公司 | Physical method of combating microorganisms |
| MX350080B (en) * | 2013-10-02 | 2017-08-25 | Pebisut De Mexico S A De C V | Anti-inflammatory composition for aiding and promoting the healing of chronic ulcerative lesions. |
| SG11201704537QA (en) * | 2014-12-19 | 2017-07-28 | Baxter Int | Flowable hemostatic composition |
| CN106237375A (en) * | 2016-08-31 | 2016-12-21 | 浙江医鼎医用敷料有限公司 | A kind of biological antibacterial film forming liquid medical dressing and preparation method thereof |
| CN109876179A (en) * | 2018-12-24 | 2019-06-14 | 深圳市琉璃光生物科技有限公司 | A kind of aerogel dressing and preparation method thereof |
| CN110559475A (en) * | 2019-09-19 | 2019-12-13 | 广州博民生物科技有限公司 | Compound liquid dressing and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105536027A (en) * | 2015-12-24 | 2016-05-04 | 南阳市汇博生物技术有限公司 | Scar treatment strip capable of lowering tissue tension and preparation method thereof |
| CN105769698A (en) * | 2016-04-14 | 2016-07-20 | 曼秀雷敦(中国)药业有限公司 | Cosmetic composition without preservative and application of cosmetic composition |
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