CN111743788A - Collagen dressing containing icodextrin - Google Patents
Collagen dressing containing icodextrin Download PDFInfo
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- CN111743788A CN111743788A CN202010603362.5A CN202010603362A CN111743788A CN 111743788 A CN111743788 A CN 111743788A CN 202010603362 A CN202010603362 A CN 202010603362A CN 111743788 A CN111743788 A CN 111743788A
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- icodextrin
- collagen
- dressing according
- phenoxyethanol
- preservative
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention provides a collagen patch dressing containing icodextrin, which comprises: the obtained dressing adopts the icodextrin combined with collagen, is used for closed soft tissues, provides a healthy and clean microenvironment for the surface of the skin, can provide collagen required by skin recovery, assists the skin to recover health more quickly, can be made into a form of non-woven fabric/gauze + stock solution, is matched with different fragrance types, and has good use feeling, convenient use and good commercialization effect.
Description
Technical Field
The invention belongs to the field of medical instruments, and particularly relates to a collagen dressing containing icodextrin.
Background
The dressing generally refers to an external material with the functions of protecting wounds and preventing secondary infection, heat loss and the like in the medical field, and at present, gauze traditional dressings and modern dressings are mainly used, and the modern dressings include sodium alginate/calcium dressings, interactive dressings, silver ion dressings, foam dressings, gel dressings and the like.
The alpha-glucan oligosaccharide is a product obtained by acting glucose transferase on maltose, the polymerization degree of the alpha-glucan oligosaccharide is 4-6 glucose units, the molecular weight of the alpha-glucan oligosaccharide is small, and the alpha-glucan oligosaccharide is mainly used for moisturizing. However, the alpha-glucan oligosaccharide has a small molecular weight, cannot form an effective protective film on the skin surface, and has a weak protective effect.
Icodextrin is dextran prepared by hydrolyzing starch, has molecular weight of 19000-25000 dalton, and has good water solubility, safety and biocompatibility. The pharmaceutical preparation taking the icodextrin as the raw material is approved to be on the market in more than 30 countries and regions, and has good safety, biocompatibility and stability; the colloidal solution prepared from the icodextrin has good ultrafiltration effect and hydration floating effect, can be used as peritoneal dialysis solution and surgical anti-adhesion flushing solution, and Cooker shows that the icodextrin has good biocompatibility in a paper published in 2002; the paper published by Mistry in 1994 shows that icodextrin solutions proved safe and effective for long-term use as peritoneal dialysis solutions in a randomized multicenter clinical trial; the patent paper published by Catena in 2012 indicated that in a single-center, prospective randomized trial, the use of 4% icodextrin was safe in patients with small intestinal obstruction, reducing the risk of intra-abdominal adhesions forming and reoccluding.
In the process of studying icodextrin, we find that the colloidal solution formed by icodextrin has the efficacy of protection, which is probably because the icodextrin solution is the colloidal solution, an effective protective film can be formed on the surface of skin, the external pollution and the invasion of harmful bacteria are prevented, and a better protective effect is achieved on the affected part.
The research of Shigemura et al indicates that prolyl-hydroxyproline appears in peripheral blood after human ingests hydrolyzed collagen, and the prolyl-hydroxyproline can stimulate the growth of fibroblasts in the skin, increase the number of skin-migrated fibroblasts, improve the conversion of epidermal cells, accelerate the flow of water through the skin layer, enhance the moisturizing capability of the skin and prevent the generation of deep wrinkles.
Disclosure of Invention
The invention aims to provide a dressing which is beneficial to moisturizing skin, preventing wrinkles and improving skin quality.
The invention provides a collagen patch dressing containing icodextrin, which comprises the following components: icodextrin, hydrolyzed collagen, polyalcohol, preservative, thickening agent and flavoring agent.
The collagen patch dressing containing the icodextrin is composed of the following components in parts by mass:
0.01-0.8% of icodextrin, 0.4-0.7% of hydrolyzed collagen, 2.4-5% of polyalcohol, 0.32-0.6% of preservative, 0.05-1.05% of thickening agent, 0.0001-0.1% of flavoring agent, and the balance of purified water.
In the collagen patch dressing containing icodextrin, the polyalcohol is at least one of 1, 2-hexanediol, ethylhexyl glycerol and pentanediol.
When the polyhydric alcohol is a mixture of 1, 2-hexanediol, ethylhexyl glycerol and pentanediol, the mass ratio of the 1, 2-hexanediol, the ethylhexyl glycerol and the pentanediol is 3-5: 1-5: 20-40.
The collagen plaster dressing containing the icodextrin is characterized in that the preservative is one or a mixture of two or three of chlorphenesin, phenoxyethanol or chlorphenesin and phenoxyethanol.
The preservative is a mixture of chlorphenesin and phenoxyethanol, and the mass ratio of the preservative to the phenoxyethanol is 2-10: 30-50.
In the collagen patch dressing containing the icodextrin, the thickening agent is hydroxyl cellulose.
The hydroxyl cellulose is hydroxymethyl cellulose or hydroxyethyl cellulose.
The collagen patch dressing containing the icodextrin is characterized in that the flavoring agent is a natural spice aromatic.
The collagen patch dressing containing the icodextrin is composed of the following components in parts by mass:
0.01-0.8% of icodextrin, 0.4-0.7% of hydrolyzed collagen, 2-4% of pentanediol, 0.02-0.1% of chlorphenesin, 0.3-0.5% of phenoxyethanol, 0.1-0.5% of ethylhexyl glycerol, 0.3-0.5% of 1, 2-hexanediol, 0.05-1.05% of hydroxyethyl cellulose, 0.0001-0.1% of sweet orange essential oil and 92-96% of purified water.
The collagen plaster dressing containing icodextrin, wherein the molecular weight of the hydrolyzed collagen is 5000 daltons.
The technical scheme disclosed by the invention has the following beneficial effects:
(1) the icodextrin is combined with collagen and is used for closed soft tissues to provide a healthy and clean microenvironment for the surface of skin.
(2) The collagen can provide collagen required by skin recovery, and assist the skin to recover health more quickly.
(3) The adhesive can be made into a non-woven fabric/gauze + stock solution form, and is matched with different fragrance types, so that the obtained adhesive dressing has good use feeling, convenient use and good commercialization effect.
Detailed Description
The present invention will be further described with reference to the following detailed description, but the scope of the present invention is not limited to the description.
Example 1:
the collagen dressing containing the icodextrin comprises the following components: 0.7% of icodextrin, 0.4% of hydrolyzed collagen, 3.2% of pentanediol, 0.03% of chlorphenesin, 0.35% of phenoxyethanol, 0.11% of ethylhexyl glycerol, 0.5% of 1, 2-hexanediol, 0.08% of hydroxyethyl cellulose, 0.01% of sweet orange essential oil and 94.62% of purified water.
Example 2:
the collagen dressing containing the icodextrin comprises the following components: 0.6% of icodextrin, 0.7% of hydrolyzed collagen, 4.1% of 1, 2-hexanediol, 0.5% of chlorphenesin, 0.09% of hydroxymethyl cellulose, 0.25% of mint essential oil and 93.76% of purified water.
Example 3:
the collagen dressing containing the icodextrin comprises the following components: 0.8% of icodextrin, 0.4% of hydrolyzed collagen, 2.4% of pentanediol, 0.6% of phenoxyethanol, 1.05% of hydroxyl cellulose, 0.02% of lavender essential oil and 94.73% of purified water.
The collagen patch dressing containing the icodextrin, which is prepared by the common preparation method of the above embodiment and non-woven fabric (each patch dressing contains 10g of the composition in the embodiment), is applied to 50 acne patients (excluding collagen allergy patients), one patch is applied every day in the first two days in the using process, one patch is applied every other day in the next two days, seven days are taken as a treatment course, in the application process, the acne patients feel the patch dressing fragrance type obtained by the invention is elegant and fresh, the application process is comfortable, no adverse reaction occurs, the acne does not continue to develop after one treatment course, and the two treatment courses are improved to a great extent.
The above examples describe specific embodiments of the present invention in detail, but the present invention is not limited to the above embodiments, and various changes can be made without departing from the gist of the present invention within the knowledge of those skilled in the art.
Claims (10)
1. The utility model provides a collagen pastes dressing that contains icodextrin which characterized in that: the collagen plaster dressing comprises the following components: icodextrin, hydrolyzed collagen, polyalcohol, preservative, thickening agent and flavoring agent.
2. The icodextrin-containing collagen patch dressing according to claim 1, wherein: the collagen plaster dressing comprises the following components in parts by mass:
0.01-0.8% of icodextrin, 0.4-0.7% of hydrolyzed collagen, 2.4-5% of polyalcohol, 0.32-0.6% of preservative, 0.05-1.05% of thickening agent, 0.0001-0.1% of flavoring agent, and the balance of purified water.
3. An icodextrin-containing collagen patch dressing according to claims 1 and 2, characterized in that: the polyalcohol is at least one of 1, 2-hexanediol, ethylhexyl glycerol and pentanediol.
4. The icodextrin-containing collagen patch dressing according to claim 3, wherein: when the polyhydric alcohol is a mixture of 1, 2-hexanediol, ethylhexyl glycerol and pentanediol, the mass ratio of the 1, 2-hexanediol, the ethylhexyl glycerol and the pentanediol is 3-5: 1-5: 20-40.
5. An icodextrin-containing collagen patch dressing according to claims 1 and 2, characterized in that: the preservative is one or a mixture of two or three of chlorphenesin, phenoxyethanol or chlorphenesin and phenoxyethanol.
6. The icodextrin-containing collagen patch dressing according to claim 5, wherein: the preservative is a mixture of chlorphenesin and phenoxyethanol, and the mass ratio of the preservative to the phenoxyethanol is 2-10: 30-50.
7. An icodextrin-containing collagen patch dressing according to claims 1 and 2, characterized in that: the thickening agent is hydroxyl cellulose.
8. The icodextrin-containing collagen patch dressing according to claim 7, wherein: the hydroxyl cellulose is hydroxymethyl cellulose or hydroxyethyl cellulose.
9. An icodextrin-containing collagen patch dressing according to claims 1 and 2, characterized in that: the flavoring agent is natural perfume aromatic.
10. An icodextrin-containing collagen patch dressing according to claims 1 and 2, characterized in that: the collagen plaster dressing comprises the following components in parts by mass:
0.01-0.8% of icodextrin, 0.4-0.7% of hydrolyzed collagen, 2-4% of pentanediol, 0.02-0.1% of chlorphenesin, 0.3-0.5% of phenoxyethanol, 0.1-0.5% of ethylhexyl glycerol, 0.3-0.5% of 1, 2-hexanediol, 0.05-1.05% of hydroxyethyl cellulose, 0.0001-0.1% of sweet orange essential oil and 92-96% of purified water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010603362.5A CN111743788A (en) | 2020-06-29 | 2020-06-29 | Collagen dressing containing icodextrin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010603362.5A CN111743788A (en) | 2020-06-29 | 2020-06-29 | Collagen dressing containing icodextrin |
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| Publication Number | Publication Date |
|---|---|
| CN111743788A true CN111743788A (en) | 2020-10-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010603362.5A Pending CN111743788A (en) | 2020-06-29 | 2020-06-29 | Collagen dressing containing icodextrin |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113786513A (en) * | 2021-10-25 | 2021-12-14 | 西安德诺海思医疗科技有限公司 | Long-term stable recombinant collagen dressing and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566371A (en) * | 2012-08-01 | 2014-02-12 | 南京神奇科技开发有限公司 | Antimicrobial physical method |
| CN105983131A (en) * | 2015-02-13 | 2016-10-05 | 陕西巨子生物技术有限公司 | Hydrogel collagen dressing especially suitable for oily skins |
| CN107137760A (en) * | 2017-05-27 | 2017-09-08 | 河南汇博医疗股份有限公司 | A kind of moisturizing maintenance dressing and preparation method thereof |
| CN108210975A (en) * | 2018-02-06 | 2018-06-29 | 青岛海洋生物医药研究院 | For treating the collagen dressing of acne |
-
2020
- 2020-06-29 CN CN202010603362.5A patent/CN111743788A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566371A (en) * | 2012-08-01 | 2014-02-12 | 南京神奇科技开发有限公司 | Antimicrobial physical method |
| CN105983131A (en) * | 2015-02-13 | 2016-10-05 | 陕西巨子生物技术有限公司 | Hydrogel collagen dressing especially suitable for oily skins |
| CN107137760A (en) * | 2017-05-27 | 2017-09-08 | 河南汇博医疗股份有限公司 | A kind of moisturizing maintenance dressing and preparation method thereof |
| CN108210975A (en) * | 2018-02-06 | 2018-06-29 | 青岛海洋生物医药研究院 | For treating the collagen dressing of acne |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113786513A (en) * | 2021-10-25 | 2021-12-14 | 西安德诺海思医疗科技有限公司 | Long-term stable recombinant collagen dressing and preparation method thereof |
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