CN108210975A - For treating the collagen dressing of acne - Google Patents

For treating the collagen dressing of acne Download PDF

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Publication number
CN108210975A
CN108210975A CN201810119795.6A CN201810119795A CN108210975A CN 108210975 A CN108210975 A CN 108210975A CN 201810119795 A CN201810119795 A CN 201810119795A CN 108210975 A CN108210975 A CN 108210975A
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China
Prior art keywords
dressing
dalton
ocean
acne
hydrolyzed collagen
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CN201810119795.6A
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Chinese (zh)
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CN108210975B (en
Inventor
于德君
李八方
王园园
代元坤
宋文山
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Haisheng Health Technology Qingdao Co ltd
Qingdao Institute of marine biomedicine
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Qingdao Institute Of Marine Biology And Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/07—Stiffening bandages
    • A61L15/10—Stiffening bandages containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents

Abstract

The present invention relates to for treating the collagen dressing of acne.Collagen dressing of the present invention includes auxiliary material liquid and dressing substrate, wherein, the dressing liquid is mainly prepared by 1~10 part of ocean Hydrolyzed Collagen, 0.5~4 part of dipotassium glycyrrhizinate, 0.2~1 part of aloe gel powder and 1000 parts of water, and the substrate is non-woven fabrics, preferably chitosan non-woven fabrics.Collagen dressing of the present invention is based on natural material, simple and safe, histocompatbility is good, non-stimulated, has good antibacterial and reduces pigment deposition effect caused by acne, has good treatment and repair to acne.

Description

For treating the collagen dressing of acne
Technical field
The present invention relates to dressing field, in particular to for treating the collagen dressing of acne.
Background technology
Acne (Acne vulgaris), also known as acne (Acne), are a kind of common skin diseases, the age was at 11~30 years old Between crowd in have 80% people suffer from this disease, be mainly in face, back, chest etc. rich in sebaceous glands position.Acne can be held Continue for many years, appearance is caused to damage or leave permanent scar and cause serious negative effect to the psychological development of patient.
Etiology analysis thinks the severity of acne and the staphylococcus aureus of epidermis and subcutaneous acne propionic acid bar Bacterium is related, and how to effectively inhibit and kill both bacteriums is the key that treatment acne.
Modern treatment acne is mainly based on oral antibiotic, hormone, tretinoin medicines and externally applied anti-inflammation medicine, the course for the treatment of The problems such as long, state of an illness easily recurs and is also easy to produce adverse reaction, and easily form scar or pigmentation.Therefore, one is developed The kind comprehensive product of safer, mild, lasting and effect, which has become, enjoys popular confidence.
In view of this, it is special to propose the present invention.
Invention content
The first object of the present invention is to provide a kind of for treating the dressing liquid of acne, and the dressing liquid is with pure natural material Based on material, simple and safe, histocompatbility is good, non-stimulated, and there is pigment deposition caused by good antibacterial and reduction acne to make With to acne with good treatment and repair.
The second object of the present invention is to provide a kind of for treating the dressing of acne, and the dressing includes aforementioned dressing base Bottom and aforementioned dressing liquid, it is easy to use, there is good treatment and repair to acne.
Above-mentioned purpose to realize the present invention, spy use following technical scheme：
For treating the dressing liquid of acne, by weight, the dressing liquid is mainly by 1~10 portion of ocean hydrolytic collagen egg In vain, 0.5~4 part of dipotassium glycyrrhizinate, 0.2~1 part of aloe gel powder and 1000 parts of water are prepared.
The raw material for preparing of dressing liquid of the present invention includes ocean Hydrolyzed Collagen, dipotassium glycyrrhizinate, aloe gel powder. Wherein, dipotassium glycyrrhizinate has the function of that antibacterial, anti-inflammatory is calm, moves back red and swollen promotion healing, by Radix Glycyrrhizae as skin conditioning agent The conditioning of sour dipotassium can alleviate the microorganism infection and inflammation of patients with acne skin of face on the whole, improve skin of face Whole physiological status, make skin be in absorb, the strong physiological status of repair ability, be conducive to follow-up ocean Hydrolyzed Collagen And the infiltration and action of aloe gel, in addition dipotassium glycyrrhizinate can be deep enough subcutaneous, also has to propionibacterium acnes good Inhibiting effect.And containing a large amount of phenols, polysaccharide and amino acid in aloe gel, to S. aureus in vitro, large intestine Bacillus and subcutaneous propionibacterium acnes etc. have good inhibiting effect, and aloe polysaccharide and vitamin have to skin it is good Moist and whitening effect.Therefore, aloe gel has targetedly inhibiting effect to the bacterium for causing acne, can play sample Simultaneous the effect of controlling, meanwhile, whitening and moist effect also have great advantage to the reparation of skin.And ocean Hydrolyzed Collagen energy Cuticula, skin corium are enough penetrated into, tyrosine residue can be competed with the tyrosine in skin, inhibit tyrosinase catalysis junket Propylhomoserin is converted into DOPA quinone, prevents the formation of melanin to a certain extent, reduces pigment deposition.Furthermore ocean hydrolytic collagen Albumen, dipotassium glycyrrhizinate, aloe gel powder are natural extract, and histocompatbility is good, non-stimulated to skin, safely may be used It leans on.
In conclusion the dipotassium glycyrrhizinate, aloe gel and ocean Hydrolyzed Collagen in dressing liquid of the present invention exist There is mutual cooperation, synergy on the whole, wherein, the opsonic action of dipotassium glycyrrhizinate can improve patient on the whole Skin condition, aloe gel and ocean protein hydrolysate is absorbed and utilized in enhancing skin, and aloe gel makees the inhibition of germ With opsonic action of the dipotassium glycyrrhizinate to skin, while its good water-retaining property can be further enhanced, be conducive to skin to sweet The absorption of potassium oxalate and ocean Hydrolyzed Collagen.And ocean Hydrolyzed Collagen is not only able to inhibit the deposition of pigment, simultaneously The amino acid can also be provided for the metabolism of skin, improve the living environment of Skin Cell, enhanced the vigor of skin and support Drag assists dipotassium glycyrrhizinate to play conditioning, therapeutic effect with aloe gel.
In some specific embodiments, by weight, the ocean Hydrolyzed Collagen is 1 part, 5 parts or 10 Part.
In some specific embodiments, the dipotassium glycyrrhizinate is 0.5 part, 2 parts or 4 parts.
In some specific embodiments, the aloe gel powder is 0.2 part, 0.5 part or 1 part.
In some specific embodiments, the molecular weight of the ocean Hydrolyzed Collagen is 400~1500 dongles , for example, 400 dalton, 500 dalton, 600 dalton, 700 dalton, 800 dalton, 900 dalton, 1000 dongles , 1100 dalton, 1200 dalton, 1300 dalton or 1400 dalton.
In some specific embodiments, the polymer dispersity index (polymer of the ocean Hydrolyzed Collagen Dispersity index, PDI)≤3.0, it is preferable that PDI≤2.4, it is highly preferred that PDI≤2.0.
In some specific embodiments, the ocean Hydrolyzed Collagen is selected from Nippi Hydrolyzed Collagens, Luo Sai Lip river Hydrolyzed Collagen, east ocean Hydrolyzed Collagen or Shandong day long Hydrolyzed Collagen.
The present invention has been unexpectedly discovered that molecular size range and PDI values influence ocean Hydrolyzed Collagen to tyrosinase Inhibiting effect.Therefore, the method for the invention is also defined the molecular weight of ocean protein hydrolysate with PDI values, in the present invention Ocean protein hydrolysate in aforementioned range has good tyrosinase inhibition.
In some specific embodiments, for human skin is suitble to use, the pH value of dressing liquid of the present invention is 4.0 ~6.0, preferably 5.0~6.0.
In some specific embodiments, the aloe gel powder is aloe vera gel powder.
The invention further relates to for treating the dressing of acne, the dressing includes dressing substrate and aforementioned dressing liquid.
In some specific embodiments, the dressing substrate is non-woven fabrics, it is preferable that the non-woven fabrics is chitosan Non-woven fabrics；It is highly preferred that in the non-woven fabrics mass fraction >=20% of chitosan or >=30% or >=50% or= 100%.
The substrate of the aforementioned dressing of the present invention is the non-woven fabrics of chitosan-containing, and there is chitosan therein excellent antibacterial to live Property, there is good bacteriostasis to the common strain such as staphylococcus aureus, Escherichia coli, Bacillus acidi lactici, it can be further Enhance therapeutic effect of the dressing to acne.
In some specific embodiments, the dressing substrate infiltration is in the dressing liquid, alternatively, the dressing base Bottom and the dressing liquid independent packaging.
Compared with prior art, beneficial effects of the present invention are：
(1) dressing liquid of the present invention, dressing pass through dipotassium glycyrrhizinate, aloe gel active material, ocean hydrolytic collagen The compatibility of polypeptide and/or chitosan has the function of killing main pathogenic bacterium of acnes, conditioning skin and inhibition pigment deposition, There is good treatment and repair to acne on the whole.
(2) dressing liquid and dressing of the present invention is based on natural material, have simple and safe, histocompatbility is good, The advantages of non-stimulated to skin.
(3) present invention further defines the molecular weight of ocean Hydrolyzed Collagen and PDI values, can further enhance described Dressing liquid and dressing are to the inhibiting effect of tyrosinase activity.
Description of the drawings
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution of the prior art Embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, in being described below Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor It puts, can also be obtained according to these attached drawings other attached drawings.
Fig. 1 is the skin of the right face of subject after treatment end；
Fig. 2 is the skin of the left face of subject after treatment end.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific Condition person, the condition suggested according to normal condition or manufacturer carry out.Reagents or instruments used without specified manufacturer is The conventional products obtained can be bought by city.
Embodiment 1
A kind of dressing for being used to treat acne, including dressing liquid and dressing substrate, wherein, by weight, the dressing Liquid mainly prepared by 1 part of ocean Hydrolyzed Collagen, 0.5 part of dipotassium glycyrrhizinate, 0.2 part of aloe gel powder and 1000 parts of water and Into；The dressing substrate is chitosan non-woven fabrics, wherein, the mass fraction of chitosan is 20%.
The ocean Hydrolyzed Collagen is Nippi Hydrolyzed Collagens, and the aloe gel powder is coagulated for aloe barbadensis Miller Rubber powder.
The specific preparation method of auxiliary material includes：1st, in an aseptic environment, by ocean Hydrolyzed Collagen, dipotassium glycyrrhizinate and reed Luxuriant growth gel powder is added in purified water, and stirring and dissolving is up to auxiliary material liquid.2nd, in an aseptic environment, by aforementioned auxiliary material liquid and chitosan Non-woven fabrics mixes, encapsulation, later irradiation sterilization.
Embodiment 2
Dressing is prepared with reference to 1 the method for embodiment, is differed only in：The dressing liquid is mainly by 5 parts of ocean water dispergation Former albumen, 2 parts of dipotassium glycyrrhizinates, 1 part of aloe gel powder and 1000 parts of water are prepared；The quality of chitosan in the non-woven fabrics Score is 30%.
Embodiment 3
Dressing is prepared with reference to 1 the method for embodiment, is differed only in：The dressing liquid is mainly hydrolyzed by 10 parts of oceans Collagen, 4 parts of dipotassium glycyrrhizinates, 1 part of aloe gel powder and 1000 parts of water are prepared；The matter of chitosan in the non-woven fabrics It is 100% to measure score.
Embodiment 4
Dressing is prepared with reference to 2 the method for embodiment, is differed only in：The mass fraction of chitosan is in the non-woven fabrics 50%.
Embodiment 5
Dressing is prepared with reference to 2 the method for embodiment, is differed only in：The mass fraction of chitosan is in the non-woven fabrics 100%.
Embodiment 6
Dressing is prepared with reference to 1 the method for embodiment, is differed only in, the ocean Hydrolyzed Collagen is Luo Sailuo seas Foreign Hydrolyzed Collagen.
Embodiment 7
Dressing is prepared with reference to 1 the method for embodiment, is differed only in, the ocean Hydrolyzed Collagen is east ocean Hydrolyzed Collagen.
Embodiment 8
Dressing is prepared with reference to 1 the method for embodiment, is differed only in, the ocean Hydrolyzed Collagen is permanent for Shandong Ocean Hydrolyzed Collagen.
Embodiment 9
Prepare dressing with reference to 1 the method for embodiment, differ only in, in preparation process, the dressing liquid with it is described Dressing substrate independent packaging and sterilization treatment.
Experimental example 1
The physicochemical property and its tyrosinase inhibition rate of ocean Hydrolyzed Collagen used in previous embodiment are detected, wherein, Specific detection mode and testing result are as follows.
1st, using Efficient numerical method method, ocean Hydrolyzed Collagen (Nippi, Luo Sai of different brands are detected Lip river, east ocean and Shandong are day long) molecular size range and polymer dispersity index (PDI), specific testing result such as 1 institute of table Show.
The physicochemical property of the different ocean Hydrolyzed Collagens of table 1
2nd, using the tyrosine of Mushroom Tyrosinase DOPA rate oxidizing process detection different brands ocean Hydrolyzed Collagen Enzyme inhibition rate, specific detection method and testing result are as follows.
1) sample treatment：The ocean Hydrolyzed Collagen of different brands is made into the solution (tyrosine of 10g/L with ultra-pure water Enzyme is cuprein, and copper ion is should not contain in solution) it is spare as sample liquid.
2) experimental implementation：Biochemical reaction is carried out in a glass tube, and each pipe adds in required pH6.8 phosphate buffers (phosphorus Sour hydrogen dipotassium 6.8g and sodium hydroxide 0.944g are settled to 1000ml), sample liquid, kojic acid solution (10g/L) and enzyme solutions (about 3.5mg tyrosinases are settled to 100ml) 10min is reacted in 37 DEG C of water-baths, L-3,4 dihydroxyphenylalanine solution (2.5g/L) is sequentially added, 10min is reacted in 37 DEG C of water-baths, surveys the light absorption value of 475nm wavelength.Experimental system design is shown in Table 2.
2 experimental system of table designs table
3) inhibiting rate computational methods：Sample represents the inhibition strength of tyrosinase activity with inhibiting rate.Sample inhibiting rate =[positive control absorbance value-(sample cell absorbance value-negative control absorbance value)]/positive control absorbance value × 100%, standard control inhibiting rate=(positive control light absorption value-standard pipe light absorption value)/positive control light absorption value × 100%, suppression Rate height processed shows it to inhibition of enzyme activity intensity highest.Standard items reference：To ensure the accuracy of experimental result, done in laboratory Detection should all be equipped with standard control.Kojic acid is selected as standard control, when different batches are tested, the inhibition of kojic acid standard control Rate will be different, and the inhibiting rate of standard control can be converted to 100%, remake after the inhibiting rate equal proportion variation of tested material Compare.The inhibiting rate that tested material is such as calculated according to above-mentioned formula is 18%, and standard control object inhibiting rate is 90%, after conversion Tested material inhibiting rate is 18%/90%=20%.
The tyrosinase inhibition rate of 3 different brands ocean Hydrolyzed Collagen of table
2nd, Analysis of test results：According to the molecular weight of ocean Hydrolyzed Collagen shown in table 1 and polymer dispersity index And tyrosinase inhibition rate shown in table 3 is it is found that the tyrosinase inhibition rate of ocean Hydrolyzed Collagen and its molecular weight, PDI Etc. related, wherein, molecular weight is below 1000 dalton, ocean Hydrolyzed Collagen of the PDI indexes below 2.4 is to junket ammonia Sour enzyme has good inhibition.
Experimental example 2
Example 5 is raw materials used and dressing finished product, detects its cytotoxicity, specific detection method is with reference to national standard GB/T 16886.5-2003/ISO 10993-5:1999, specific testing result is as shown in table 4.
Toxicity point is carried out to sample with respect to proliferation rate (relative growth rate, RGR) according to detection gained cell Grade and qualified sex determination, specific grade scale are：
0 grade：RCG >=100%；1 grade：99% >=RCG >=75；2 grades：74≥RCG≥50；3 grades：49≥RCG≥25；4 Grade：24≥RGR≥1；5 grades=0.
Sample passes criterion：0~1 rank is qualification；Whether judge 2 grades according to cellular morphology comprehensive analysis is conjunction Lattice, 3~5 grades is unqualified.
According to experimental result described in table 4 it is found that raw material of the present invention and the equal no cytotoxicity of finished product, safely may be used It leans on.
4 cell toxicity test result of table
Experimental example 3
1~5 dressing of Example detects it to staphylococcus aureus (ATCC6538) and propionibacterium acnes (ATCC11827) inhibiting effect, specific detection method is referring to national standard GB/T 20944, and specific testing result is referring to table 5.According to Result of the test shown in table 5 is it is found that dressing of the present invention has good suppression to staphylococcus aureus and propionibacterium acnes Bacterium acts on.
5 bacteriostatic test result of table
Experimental example 4
Two subjects are convened, dressing described in embodiment 5 are tried out, concrete condition is as follows：
1st, subject
Quantity：2；Gender：Man；Age：25~33 years old；Physiological status：Facial moderate acne, it is throughout the year red and swollen, acne compared with Firmly.
2nd, test method
Half face is tested, and 2 people use dressing described in the embodiment of the present invention 4 for right half of face, and left one side of something face is as control.It is real Test the period 4 weeks, usage time is 20~30min/ times, is made later using 2~3 times weekly daily using dressing 1 time within first 10 days It it is 20~30min/ times with the time.
3rd, result of the test
After the test, it convenes 7~8 people are blind to the left and right face skin situation progress of two subjects to comment, thinks two people The face acnes of right side skin significantly reduce, scar subtracts light, glossiness and increases, and skin integral status is significantly better than left side skin. Wherein a subject ties in the results of comparison of left and right facial skin after the test as shown in Fig. 1~2 according to figure Fruit it is found that after dressing treatment, the right face acne situation of subject be improved significantly.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent Pipe is described in detail the present invention with reference to foregoing embodiments, but it will be understood by those of ordinary skill in the art that：Its It can still modify to the technical solution recorded in foregoing embodiments either to which part or all technical features Carry out equivalent replacement；And these modifications or replacement, various embodiments of the present invention skill that it does not separate the essence of the corresponding technical solution The range of art scheme.

Claims (10)

1. for treating the dressing liquid of acne, which is characterized in that by weight, the dressing liquid is mainly by 1~10 part of ocean Hydrolyzed Collagen, 0.5~4 part of dipotassium glycyrrhizinate, 0.2~1 part of aloe gel powder and 1000 parts of water are prepared.
2. dressing liquid according to claim 1, which is characterized in that by weight, the ocean Hydrolyzed Collagen is 1 Part, 5 parts or 10 parts；The dipotassium glycyrrhizinate is 0.5 part, 2 parts or 4 parts；The aloe gel powder is 0.2 part, 0.5 part or 1 part.
3. dressing liquid according to claim 1, which is characterized in that the molecular weight of the ocean Hydrolyzed Collagen is 400 ~1500 dalton, for example, 400 dalton, 500 dalton, 600 dalton, 700 dalton, 800 dalton, 900 dongles , 1000 dalton, 1100 dalton, 1200 dalton, 1300 dalton or 1400 dalton.
4. dressing liquid according to claim 1, which is characterized in that the polymer dispersity of the ocean Hydrolyzed Collagen Index (polymer dispersity index, PDI)≤3.0, it is preferable that PDI≤2.4, it is highly preferred that PDI≤2.0.
5. dressing liquid according to claim 1, which is characterized in that the ocean Hydrolyzed Collagen is hydrolyzed selected from Nippi Collagen, Luo Sailuo Hydrolyzed Collagens, east ocean Hydrolyzed Collagen or Shandong day long Hydrolyzed Collagen.
6. dressing liquid according to claim 1, which is characterized in that the pH value of the dressing liquid is 4.0~6.0, preferably 5.0~6.0.
7. dressing liquid according to claim 1, which is characterized in that the aloe gel powder is aloe vera gel powder.
8. for treating the dressing of acne, which is characterized in that the dressing includes any one of dressing substrate and claim 1~7 The dressing liquid.
9. dressing according to claim 8, which is characterized in that the dressing substrate is non-woven fabrics, it is preferable that the nonwoven Cloth is chitosan non-woven fabrics；It is highly preferred that in the non-woven fabrics chitosan mass fraction >=20%.
10. dressing according to claim 8 or claim 9, which is characterized in that the dressing substrate is infiltrated in the dressing liquid, Alternatively, the dressing substrate and the dressing liquid independent packaging.
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CN111743788A (en) * 2020-06-29 2020-10-09 华仁药业股份有限公司 Collagen dressing containing icodextrin
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CN113577364A (en) * 2021-08-13 2021-11-02 常州谙美生物科技有限公司 Medical dressing for after-sun repair
CN113616850A (en) * 2021-09-02 2021-11-09 长春工业大学 High-transparency skin repair hydrogel dressing and preparation method thereof

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