CN1102153C - Water-soluble chitosan and its capsules - Google Patents
Water-soluble chitosan and its capsules Download PDFInfo
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- CN1102153C CN1102153C CN00113650A CN00113650A CN1102153C CN 1102153 C CN1102153 C CN 1102153C CN 00113650 A CN00113650 A CN 00113650A CN 00113650 A CN00113650 A CN 00113650A CN 1102153 C CN1102153 C CN 1102153C
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- chitosan
- weight
- water
- soluble chitosan
- capsule
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- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
The present invention discloses soluble chitosan and a capsule thereof. Crudely extracted chitin is deacetylated by concentrated sodium hydroxide so as to obtain crude chitosan; the product of the crude chitosan stands still for hydrolyzing for 2 to 4 hours at temperature of 5 to 25DEG C so that the soluble chitosan is prepared. The capsule of the chitosan comprises 0.1 to 0.5g of soluble chitosan contained in the capsule. The capsule has favorable therapeutic effect on cancers, cardio-cerebrovascular diseases, diabetes, hepatitis, etc. and is favorable effect for quickening the healing of wounds.
Description
The present invention relates to a kind of preparation method of medical-care health food water-soluble chitosan.
Chitosan has very big value aspect health care, but it have reduce cholesterol in the blood, can regulate the best potential of hydrogen of body fluid pH value 7.4, can activating human body cells, pair cell has and induces that thereby immunization has better curative effect to cancer, cardiovascular and cerebrovascular diseases, diabetes, hepatitis, accelerating wound etc. with the repair enhancing body.This point has obtained studies confirm that.Existing chitosan product is insoluble in water, and must be under sour environment solubilized, promptly its pH value must be lower than 6, therefore some difficulty in the application of food.There are some researches show that the chitosan molecule amount is 3000 following persons,, good water solubility, be easy to be absorbed and have the function of stronger inhibition and treatment cancer by human body because molecular weight is little.
The object of the present invention is to provide a kind of good water solubility, be easy to the preparation method of the water-soluble chitosan that absorbed by human body.
The object of the present invention is achieved like this: the preparation method of this water-soluble chitosan is that the chitin that will slightly carry is handled at 75～95 ℃ with the concentrated sodium hydroxide of 2～4 times 55～70% (weight) of its weight and carried out the deacetylation reaction in 10～20 hours; obtain thick chitosan; again thick chitosan product is dissolved in the dilute acetic acid of 8～10 times 3～6% (volume) of its weight; the high alkali liquid that adds 10% (weight) again is to becoming mucus; leaving standstill hydrolysis under 5～25 ℃ after 2～4 hours; be neutralized to pH value 8～9 to floss occurring with diluted acid; constantly be stirred to floss and stop to produce, make the water-soluble chitosan elaboration except that behind the sodium-chlor again.
This chitosan is soluble in water, can be absorbed by the body, and makes the first-selected functional health-care food of this popular of chitosan can bring into play its medical care effect better.
Embodiment 1:
Thick chitin 100 grams: the concentrated sodium hydroxide with 300 grams 65% (weight) restrains at 80 ℃ of chitosan crude products of handling to obtain deacetylation 95% in 10～20 hours 80; Crude product is dissolved in 800 gram 5% (volume) dilute acetic acid, slowly add concentrated base about 10% (weight) to mucus occurring, be cooled to 10 ℃, left standstill hydrolysis 3 hours, be neutralized to pH value 8 and floss occurs with 2N hydrochloric acid, constantly be stirred to floss and stop to produce, again except that making water-soluble chitosan elaboration 70 grams behind the sodium-chlor.
Claims (1)
1, the preparation method of water-soluble chitosan is characterized in that may further comprise the steps:
(1), the chitin that will slightly carry handles at 75～95 ℃ with the concentrated sodium hydroxide of 2～4 times 55～70% (weight) of its weight and carried out the deacetylation reaction in 10～20 hours, obtains thick chitosan;
(2), thick chitosan product is dissolved in the dilute acetic acid of 8～10 times 3～6% (volume) of its weight, the high alkali liquid that adds 10% (weight) again is to becoming mucus, leaving standstill hydrolysis after 2～4 hours under 5～25 ℃, be neutralized to pH value 8～9 to floss occurring with diluted acid, constantly be stirred to floss and stop to produce, make molecular weight at the water-soluble chitosan elaboration below 3000 except that behind the sodium-chlor again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00113650A CN1102153C (en) | 2000-08-28 | 2000-08-28 | Water-soluble chitosan and its capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00113650A CN1102153C (en) | 2000-08-28 | 2000-08-28 | Water-soluble chitosan and its capsules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1283635A CN1283635A (en) | 2001-02-14 |
| CN1102153C true CN1102153C (en) | 2003-02-26 |
Family
ID=4583415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00113650A Expired - Fee Related CN1102153C (en) | 2000-08-28 | 2000-08-28 | Water-soluble chitosan and its capsules |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1102153C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100364420C (en) * | 2005-02-01 | 2008-01-30 | 黄恒燊 | Sour milk powder containing chitosan |
| CN100391981C (en) * | 2005-12-16 | 2008-06-04 | 武汉大学 | Method for preparing complete water soluble low molecular weight chitosan/chitooligosaccharace |
| CN101492543B (en) * | 2008-01-25 | 2011-09-07 | 上海工程技术大学 | Process for preparing granule chitosan |
| CN105125737A (en) * | 2015-09-10 | 2015-12-09 | 青岛银色世纪健康产业集团有限公司 | Chitosan compound with function of enhancing immunity, preparation method thereof, and capsules containing chitosan compound |
| CN105456227B (en) * | 2015-12-31 | 2019-02-05 | 广东药科大学 | A kind of chitosan capsules and preparation method thereof |
| CN107296281A (en) * | 2017-07-18 | 2017-10-27 | 迪沙药业集团有限公司 | A kind of lipid-lowering health food |
| CN109456421A (en) * | 2018-10-30 | 2019-03-12 | 江南大学 | A kind of preparation of water soluble chitosan material and application method |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH039301A (en) * | 1989-06-06 | 1991-01-17 | Dainippon Printing Co Ltd | Production of lens sheet |
| CN1097012A (en) * | 1993-06-30 | 1995-01-04 | 上海科学技术大学 | The preparation method of N,O-CMC |
| JPH0790005A (en) * | 1993-09-24 | 1995-04-04 | Daiichi Seimo Kk | Production of water-soluble chitosan |
| RU2099351C1 (en) * | 1996-01-10 | 1997-12-20 | Владимир Николаевич Чернецкий | Method for production of water soluble derivatives of chitosan |
| JPH115803A (en) * | 1997-06-18 | 1999-01-12 | Tottori Pref Gov | Production of amorphous water-soluble partially deacetylated chitin |
| RU2126012C1 (en) * | 1997-03-17 | 1999-02-10 | Российский Университет Дружбы Народов | Process for preparing water-soluble oligosaccharides |
| KR19990049775A (en) * | 1997-12-15 | 1999-07-05 | 전원중 | Method for preparing water-soluble chitosan oligosaccharides |
| KR19990069029A (en) * | 1998-02-04 | 1999-09-06 | 김공수 | Water-soluble low molecular chitin, chitosan and oligosaccharides thereof |
| JPH11276189A (en) * | 1998-03-30 | 1999-10-12 | Tottori Prefecture | Production of oligosaccharide with enzyme using amorphous water-soluble partially deacetylated chitin as substrate |
| CN1242377A (en) * | 1998-07-20 | 2000-01-26 | 北京化工大学 | Method for preparing chitosan and low polymerized chitosan |
-
2000
- 2000-08-28 CN CN00113650A patent/CN1102153C/en not_active Expired - Fee Related
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH039301A (en) * | 1989-06-06 | 1991-01-17 | Dainippon Printing Co Ltd | Production of lens sheet |
| CN1097012A (en) * | 1993-06-30 | 1995-01-04 | 上海科学技术大学 | The preparation method of N,O-CMC |
| JPH0790005A (en) * | 1993-09-24 | 1995-04-04 | Daiichi Seimo Kk | Production of water-soluble chitosan |
| RU2099351C1 (en) * | 1996-01-10 | 1997-12-20 | Владимир Николаевич Чернецкий | Method for production of water soluble derivatives of chitosan |
| RU2126012C1 (en) * | 1997-03-17 | 1999-02-10 | Российский Университет Дружбы Народов | Process for preparing water-soluble oligosaccharides |
| JPH115803A (en) * | 1997-06-18 | 1999-01-12 | Tottori Pref Gov | Production of amorphous water-soluble partially deacetylated chitin |
| KR19990049775A (en) * | 1997-12-15 | 1999-07-05 | 전원중 | Method for preparing water-soluble chitosan oligosaccharides |
| KR19990069029A (en) * | 1998-02-04 | 1999-09-06 | 김공수 | Water-soluble low molecular chitin, chitosan and oligosaccharides thereof |
| JPH11276189A (en) * | 1998-03-30 | 1999-10-12 | Tottori Prefecture | Production of oligosaccharide with enzyme using amorphous water-soluble partially deacetylated chitin as substrate |
| CN1242377A (en) * | 1998-07-20 | 2000-01-26 | 北京化工大学 | Method for preparing chitosan and low polymerized chitosan |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1283635A (en) | 2001-02-14 |
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