CN105125737A - Chitosan compound with function of enhancing immunity, preparation method thereof, and capsules containing chitosan compound - Google Patents
Chitosan compound with function of enhancing immunity, preparation method thereof, and capsules containing chitosan compound Download PDFInfo
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Abstract
The invention relates to a chitosan compound with a function of enhancing immunity. The chitosan compound comprises chitosan, Chinese wolfberry fruit extract, ganoderma lucidum extract and ginkgo leaf extract, wherein the weight ratio of the chitosan, Chinese wolfberry fruit extract, ganoderma lucidum extract and ginkgo leaf extract is 40-60:30-50:10-20:5-8. The chitosan compound has the advantages that the high-purity chitosan is prepared by a microwave method, and the high-purity chitosan is combined with the extracts of traditional Chinese medicine Chinese wolfberry fruit, ganoderma lucidum and ginkgo leaf to jointly increase body immunity, comprehensively adjust human body function balance in a bidirectional manner, mobilize body internal vitality and adjust the body metabolism function; the active components of the chitosan compound are allowed to enter five internal organs and tonify the whole body so as to achieve healthcare effects of strengthening and consolidating body resistance and strengthening physical health, and accordingly the body immunity is enhanced fundamentally.
Description
Technical field
The present invention relates to health product and preparation method thereof technical field, the capsule of chitosan complexes that particularly there is the chitosan complexes of enhancing immunity function, its preparation method and prepare containing the method.
Background technology
Along with Chinese society expanding economy and living standards of the people improve constantly, the dietary structure of people, living habit and living environment there occurs great variety, living habit as serious and bad in social life tempo increase, environmental pollution, cause the body health level of people to decline gradually, especially the quantity of the low crowd of immunity of organisms is in continuous increase.The health promoting product of enhancing immunity is a lot of in the market, but existing enhancing immunity capsule class product prescription and functionally majority is all comparatively single, not from the compatibility that the comprehensive mechanism of human body regulates consideration rigorous.
Chitosan is a kind of dietary fiber of animal origin of uniqueness, safety non-toxic, there is good biocompatibility and biodegradable, all be widely used in fields such as food, medicine, agriculturals, the focus of the Recent study especially of the application especially in physiological function, studies have reported that, chitosan has blood fat reducing, improves immunity, gives protection against cancer, prevents and treats diabetes, antiulcer, promotion wound healing, promotes the functions such as epithelial cell growth, is described as life the 6th key element.Wherein, effect of chitosan enhancing immunity is deeply concerned, a large amount of animal and clinical trial certificate, and chitosan has the function of enhancing immunity.(2001) Lv Zhongming etc. have carried out the research of chitosan immunoregulation effect, and evaluate from mouse cell immunity, humoral immunization, monocytes/macrophages phagocytic function three aspects, obtain conclusion, chitosan has immunoregulation effect to mice; (2007) Shi Binlin reports the progress of chitosan to animal immune regulating action; (2008) Cao Xiuming etc. report the progress that chitosan and oligochitosan regulate cellular immunization and humoral immunization; (2011) Jiang Xia etc. report the impact of chitosan on Immune Function In Animals and the progress of mechanism thereof; More than research report all shows that chitosan has immunoregulation effect to animal.Under the environment of ecological balance, people just can absorb enough chitosans to complete the function such as activating cell, immunity moderation from diet, but in the modern life, natural food chain destroys serious, and human body has been in chitin deficiency state.
Summary of the invention
For problems of the prior art, the object of the present invention is to provide chitosan complexes, its preparation method and the capsule of chitosan complexes prepared containing the method with enhancing immunity function.
Technical scheme of the present invention is:
There is a chitosan complexes for enhancing immunity function, be made up of according to weight ratio following component:
Chitosan: Fructus Lycii extract: Ganoderma extract: Folium Ginkgo extract=40-60:30-50:10-20:5-8.
On the basis of such scheme, a kind of chitosan complexes with enhancing immunity function, is made up of according to weight ratio following component:
Chitosan: Fructus Lycii extract: Ganoderma extract: Folium Ginkgo extract=45:33:15:7.
On the basis of such scheme, described chitosan is prepared from by following methods:
(1) join in 50%NaOH solution by chitin in the ratio of 1:10-15, microwave heating under microwave power 650W condition, temperature maintains 80 DEG C, reaction 20min; To be cooled to room temperature filter, repeatedly rinse to neutrality with pure water, dry; Obtain chitosan semifinished product; The chitosan semifinished product obtained is repeated above-mentioned steps 1-2 time;
(2) be dissolved in 5% acetic acid by the chitosan semifinished product that step (1) is obtained, cross and filter insoluble matter, then separate out colloid substances by the NaOH solution that concentration is 10%, filter, washing is to neutral, dry, obtains chitosan highly finished product.
There is a preparation method for the chitosan complexes of enhancing immunity function as above, under concrete steps:
(1), under stirring condition, 50-100g chitosan being dissolved in 20-40L concentration is in 1% (v/v) acetic acid solution; Then, use distilled water diluting chitosan solution, make its ultimate density be 2mg/ml; The pH value regulating chitosan solution with 1M sodium hydroxide solution is 6;
(2) Fructus Lycii extract, Ganoderma extract and Folium Ginkgo extract are slowly joined in order in chitosan solution, ultrasonic power is 450W, working time 20s, intermittent time 15s, works 90 times, obtains embedding suspension;
(3) adopt spray drying technology, obtain microspherulite diameter at the microsphere of 10-150 μm.
As above the capsule with enhancing immunity function chitosan complex that prepared by method, the content of capsule is this complex.
Fructus Lycii extract: Xi'an Yile Bio-Tech Co., Ltd.
Ganoderma extract: Xi'an Yile Bio-Tech Co., Ltd.
Folium Ginkgo extract: Xi'an Yile Bio-Tech Co., Ltd.
Chitosan (chitosan) is that the chitin (chitin) extensively existed by nature obtains through deacetylation, and chemical name is Chitosan (1-4)-2-amino-B-D glucose.Chitosan deacetylation degree (D.D) determines the number of amido on macromolecular chain (NH2) content; and D.D increases; because amido is protonated and make chitosan charged group in dilute acid soln increase; charge density of polyelectrolyte increases; its result will cause its structure, the change in character and performance.From 1859, after first Frenchman Rouget obtains chitosan, the premium properties such as the biological functionality of this natural polymer and the compatibility, blood compatibility, safety, microbic resolvability, by all trades and professions extensive concern, achieve major progress at the applied research of the numerous areas such as medicine, food, chemical industry, cosmetics, water treatment, METAL EXTRACTION and recovery, biochemistry and biomedical engineering.
The biological activity of chitosan is a lot, and the activity that we pay close attention to here has: 1. have immunoregulatory activity.Chitosan has the series of biologic effect activating body immune system, mediation body immune system, improves cytophagous systemic-function.Macrophage Surface also exists the receptor of bacterial polysaccharides, and chitosan is as the analog of bacterial polysaccharides, can activate by stimulating expression of macrophage, produce following reaction: promote its phagocytic function, strengthen its cooperative effect in other immunne response, thus realize the adjustment of body to T cell, NK cell and B cell, the cellullar immunologic response of mediation body and humoral immunoresponse(HI).Therefore, chitosan has the immunoregulation effect to body.
2. other medical science function.Chitosan can reduce the cholesterol concentration in serum and liver, for cholesterol-lowering agent.Chitosan can strengthen liver function, prevents the liver caused due to excessive consumption of alcohol to be still drank after a night, and to effect that the heavy metal remained in vivo, toxin, pesticide, chemical pigment have absorption and drain.After cancer patient takes chitosan, the lymphocyte in vivo with immunologic function can be swashed, normal cell and cancerous cell can be differentiated, and kill cancerous cell.PH value in chitosan energy control agent, to alkalescence, improves the utilization rate of insulin, is conducive to preventing and treating diabetes.In addition, it also has the function of endocrine regulation system, makes insulin secretion normal, suppresses blood glucose to raise, reduces blood fat.
Fructus Lycii: sweet in the mouth, property is put down; Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Ganoderma: warm in nature, lightly seasoned; Function cures mainly: 1, malaise, insomnia, palpitation with fear.Can reinforcing the heart blood, the beneficial motive, tranquilizing mind, therefore availablely control the disease such as malaise caused by insufficiency of vital energy and blood, lack of preservation of spirit, insomnia, palpitation with fear, dreaminess, forgetful, the tired Mental fatigue of body, lack of appetite.2, cough with asthma abundant expectoration.Replenishing and restoring lung-QI, warming the lung for resolving phlegm, relieving cough and asthma, often can control phlegm retention syndrome, see cold physique cough, abundant expectoration asthma person, especially to phlegm-damp type or asthenic cold type curative effect better.3, consumptive disease.These product have invigorating QI and blood effect, therefore conventional control the diseases such as asthenia is losed heart, anorexia, the limbs with coldness or irritated xerostomia.
Folium Ginkgo, sweet in the mouth, hardship, puckery, property is put down.GUIXIN, lung meridian.There is blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, astringe the lung and relieving asthma, change effect of turbid blood fat reducing.For obstruction of collaterals by blood stasis, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, cough and asthma due to lung deficiency, hyperlipemia.
Beneficial effect of the present invention:
The definite effect that marine active functional factor chitosan plays by the chitosan complexes with enhancing immunity function of the present invention on Organism immunoregulation and traditional drugs are eaten and are combined with mending Fructus Lycii, Ganoderma, the Folium Ginkgo extract nursed one's health, common performance improves Abwehrkraft des Koepers effect, comprehensive two-ways regulation function of human body balance, transfer internal body vigor, regulate human metabolism's function, improve autoimmunity.Really make complex active ingredient of the present invention enter the five internal organs, completion body, reach the health care effectiveness of strengthening the body resistance, building body, thus fundamentally enhancing human body immunity power.
The chitosan complexes with enhancing immunity function of the present invention, be combined using chitosan as carrier with Chinese medicine activated complex, wherein chitosan and Fructus Lycii extract, Ganoderma extract and Folium Ginkgo extract collaborative compatibility mutually, reaches the effect of enhancing immunity; Meanwhile, the present invention adopts ultrasonic emulsification technology to obtain particle diameter at the microsphere of about 10-150 μm, and bioavailability is high.
Complex is first according to theory of Chinese medical science selection, and wherein: Fructus Lycii nourishing the liver and kidney, replenishing vital essence to improve eyesight is monarch; Ganoderma reinforcing the heart blood, the beneficial motive, tranquilizing mind; For minister; Folium Ginkgo blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, auxiliary Fructus Lycii and Ganoderma play larger effect; For assistant; Three kinds of components, under the effect of chitosan, are carrier with chitosan, are beneficial to absorption; Meanwhile, chitosan and three kinds of components are worked in coordination with mutually, play the effect of better enhancing immunity.
Repeatedly carry out microwave radiation heating alkali treatment is adopted to substitute the alkali treatment of Conventional conduction Convective Heating, the acetyl group being hydrolyzed and taking off is removed in time in conjunction with interval washing intermedium, can high efficiency, low energy consumption the high deacetylized refining chitosan of acquisition, through 2-3 microwave thermal alkali treatment, refining chitosan takes off acetyl can reach more than 95%; And prior heat treatment of comparing mode intermedium contacts with concentrated base for a long time, microwave rapid thermal treatment takes off acetyl mode can reduce chitosan molecule chain degradation rate, and substantially increase the yield of high-viscosity chitosan, viscosity is at 7.5*10
-3the refining chitosan yield of more than Pa.s can reach 93.7%.
Capsule 's content of the present invention adopts ultrasonic emulsification technology, take chitosan as carrier adsorption embedding plurality of Chinese active component, the interval microsphere of specified particle diameter is obtained again with fast spraying dry technology, when take enter human body alimentary canal time, the dispersion effect that this microsphere compound can make the multiple efficacies factor reach maximum, thus strengthen the absorbability of herbal function composition, and improve bioavailability.
Detailed description of the invention
Embodiment 1
A preparation method for chitosan, concrete steps are as follows:
(1) chitin is joined in 50%NaOH solution in the ratio of 1:15, under microwave power 650W condition, microwave heating 80 DEG C reaction 20min; To be cooled to room temperature filter, repeatedly rinse to neutrality with pure water, dry; Obtain chitosan semifinished product; The chitosan semifinished product obtained is repeated above-mentioned steps 2 times;
(2) be dissolved in 5% acetic acid by the chitosan semifinished product that step (1) is obtained, cross and filter insoluble matter, then separate out colloid substances by the NaOH solution that concentration is 10%, filter, washing is to neutral, dry, obtains chitosan highly finished product.
Embodiment 2
There is a chitosan complexes for enhancing immunity function, be made up of according to weight ratio following component:
Chitosan: Fructus Lycii extract: Ganoderma extract: Folium Ginkgo extract=45:33:15:7.
Under preparation method concrete steps:
(1), under stirring condition, 50g chitosan being dissolved in 20L concentration is in 1% (v/v) acetic acid solution; Then, use distilled water diluting chitosan solution, make its ultimate density be 2mg/ml; The pH value regulating chitosan solution with 1M sodium hydroxide solution is 6;
(2) Fructus Lycii extract, Ganoderma extract and Folium Ginkgo extract are slowly joined in order in chitosan solution, ultrasonic power is 450W, working time 20s, intermittent time 15s, works 90 times, obtains embedding suspension;
(3) adopt spray drying technology, obtain finished microballoon products.
Have a capsule for enhancing immunity function, be made up of softgel shell and content, described content is chitosan complexes prepared by said method, and in each capsule, the content of chitosan complexes is 0.28g.The present embodiment prepares capsule amount and instructions of taking is: every day 2 times, each 3, warm water delivery service.
Embodiment 3
There is a chitosan complexes for enhancing immunity function, be made up of according to weight ratio following component:
Chitosan: Fructus Lycii extract: Ganoderma extract: Folium Ginkgo extract=50:32:11:7.
Under preparation method concrete steps:
(1), under stirring condition, 80g chitosan being dissolved in 32L concentration is in 1% (v/v) acetic acid solution; Then, use distilled water diluting chitosan solution, make its ultimate density be 2mg/ml; The pH value regulating chitosan solution with 1M sodium hydroxide solution is 6;
(2) Fructus Lycii extract, Ganoderma extract and Folium Ginkgo extract are slowly joined in order in chitosan solution, ultrasonic power is 450W, working time 20s, intermittent time 15s, works 90 times, obtains embedding suspension;
(3) adopt spray drying technology, obtain finished microballoon products.
Have a capsule for enhancing immunity function, be made up of softgel shell and content, described content is chitosan complexes prepared by said method, and in each capsule, the content of chitosan complexes is 0.28g.The present embodiment prepares capsule amount and instructions of taking is: every day 2 times, each 3, warm water delivery service.
Embodiment 4
There is a chitosan complexes for enhancing immunity function, be made up of according to weight ratio following component:
Chitosan: Fructus Lycii extract: Ganoderma extract: Folium Ginkgo extract=55:30:10:5.
Under preparation method concrete steps:
(1), under stirring condition, 100g chitosan being dissolved in 40L concentration is in 1% (v/v) acetic acid solution; Then, use distilled water diluting chitosan solution, make its ultimate density be 2mg/ml; The pH value regulating chitosan solution with 1M sodium hydroxide solution is 6;
(2) Fructus Lycii extract, Ganoderma extract and Folium Ginkgo extract are slowly joined in order in chitosan solution, ultrasonic power is 450W, working time 20s, intermittent time 15s, works 90 times, must embed suspension after ultrasonic 30min;
(3) adopt spray drying technology, obtain finished microballoon products.
Have a capsule for enhancing immunity function, be made up of softgel shell and content, described content is chitosan complexes prepared by said method, and in each capsule, the content of chitosan complexes is 0.28g.The present embodiment prepares capsule amount and instructions of taking is: every day 2 times, each 3, warm water delivery service.
A kind of capsule enhancing immunity effect, efficiency test evaluation with enhancing immunity function prepared by embodiment 2-4 is as follows:
Experimental animal: 12-16gBALB/c children Mus 130, be divided into 7 groups at random, 6 test group often organize 20, matched group 10.
Taking dose: test group recommends dose 5 multiple dose (8.4g/d) filling to feed by normal human, and matched group is filled with and fed equivalent starch; Feed with after 4 weeks continuously, last fill with to feed put to death each test group 10 mices, matched group 5 mices at random after 4 hours, separating immune organ is weighed; Remain each test group 10 mices, matched group 5 mices continuation fillings were fed after 2 weeks, last filling hello execution after 4 hours, separating immune organ is weighed.
Test group arranges as follows:
Test group 1: examination takes capsule 's content and obtains by embodiment 2 method;
Test group 2: examination takes capsule 's content and obtains through common three-dimensional blender fill by 4 kinds of raw material components in embodiment 2;
Test group 3: examination takes capsule 's content and obtains by embodiment 3 method;
Test group 4: examination takes capsule 's content and obtains through common three-dimensional blender fill by 4 kinds of raw material components in embodiment 3;
Test group 5: examination takes capsule 's content and obtains by embodiment 4 method;
Test group 6: examination takes capsule 's content and obtains through common three-dimensional blender fill by 4 kinds of raw material components in embodiment 4;
Matched group: wait dosage starch to gavage.
Test evaluation index: fill with and feed mice weightening finish after 4 weeks, 6 weeks, thymus/body weight ratio, spleen/body weight ratio.
Table 1 is filled with and is fed result of the test after 4 weeks
Note: * P<0.05, * * P<0.01 compared with matched group
Table 2 is filled with and is fed result of the test after 6 weeks
Note: * P<0.05, * * P<0.01 compared with matched group
As can be seen from the test results, capsule prepared by the chitosan complexes that embodiment of the present invention 2-4 obtains, there is the effect obviously strengthening immunologic function, and test group 1,3,5 mice fill with feed to fill with test group 2,4,6 mice after 4 weeks hello within 6 weeks, obtain close evaluation index afterwards, illustrate that the chitosan microball complex of preparation can be utilized by efficient absorption, the growth of significant stimulation mouse immune organ, and safe without toxic side effect.
Use the capsule of preparation, become variable concentrations with distilled water dissolved dilution, carry out safety toxicology inspection and evaluation according to Ministry of Public Health " health food inspection and assessment technical specification " (2003) to this product, concrete outcome is as follows:
1, acute oral toxicity test: in anthology inventive embodiments 1, prepared capsule the acute toxicity tests is SD rat acute per os MTD>15g/kgbw, belongs to non-toxic type according to acute toxicity classification.
2, genetic toxicology experiment: Salmonella reversion test, mice bone marrow micronucleus and mouse sperm distortion test result are feminine gender, show that this tested material is without mutagenic action.
3, rat 30 days feeding trials: in the embodiment of the present invention 1, prepared capsule is by 30,70 and 100 times of day for human beings recommended amounts, if dosage group is given and rat feeds 30 days, duration of test, each treated animal vegetative activity is normal.During off-test, each dosage group rat body weight and food utilization compare with matched group, difference that there are no significant.Difference that the Testing index such as the organ coefficient mensuration of each group of rat, blood test in latter stage (erythrocyte, hemoglobin, platelet), biochemical indicator inspection in latter stage (liver function, kidney merit, blood fat and blood glucose) compare with matched group that there are no significant.Histopathological examination is done to the internal organs (liver, kidney, stomach, jejunum, spleen, testis and ovary) of laboratory animal, has no specific lesions.
Show according to above-mentioned toxicologic study, prepared capsule is safety, nontoxic level.
Use capsule of the present invention, according to " health food inspection and assessment technical specification " (Ministry of Public Health 2003), this product is carried out to the zoopery of enhancing immunity function.
Adopt the male Balb/c mice of SPF level, capsule 's content of the present invention presses 10,20,30 times of continuous gavage 30d of human body recommended dose, and result shows: capsule 's content 0.37g/kg.bw of the present invention and 1.12g/kg.bw dosage group mouse spleen/body weight ratio are significantly higher than blank group; In the mouse spleen lymphocyte transformation experiment of ConA induction, capsule 's content 1.12g/kg.bw dosage group OD value difference value of the present invention is significantly greater than blank group; In antibody-producting cell detects, capsule 's content 0.37g/kg.bw of the present invention and 0.75g/kg.bw dosage group plaque number are significantly higher than blank group; In NK cytoactive detects, capsule 's content 0.37g/kg.bw of the present invention and 0.75g/kg.bw dosage group NK cytoactive rate are significantly higher than blank group.According to " health food inspection and assessment technical specification " (Ministry of Public Health 2003), this sample is pointed out to have the function of enhancing immunity.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. there is a chitosan complexes for enhancing immunity function, it is characterized in that, be made up of according to weight ratio following component:
Chitosan: Fructus Lycii extract: Ganoderma extract: Folium Ginkgo extract=40-60:30-50:10-20:5-8.
2. the chitosan complexes with enhancing immunity function according to claim 1, is characterized in that, is made up of according to weight ratio following component:
Chitosan: Fructus Lycii extract: Ganoderma extract: Folium Ginkgo extract=45:33:15:7.
3. the chitosan complexes with enhancing immunity function according to claim 1, is characterized in that, described chitosan is prepared from by following methods:
(1) join in 50%NaOH solution by chitin in the ratio of 1:10-15, microwave heating under microwave power 650W condition, temperature maintains 80 DEG C, reaction 20min; To be cooled to room temperature filter, repeatedly rinse to neutrality with pure water, dry; Obtain chitosan semifinished product; The chitosan semifinished product obtained is repeated above-mentioned steps 1-2 time;
(2) be dissolved in 5% acetic acid by the chitosan semifinished product that step (1) is obtained, cross and filter insoluble matter, then separate out colloid substances by the NaOH solution that concentration is 10%, filter, washing is to neutral, dry, obtains chitosan highly finished product.
4. the preparation method with the chitosan complexes of enhancing immunity function according to claim 1,2 or 3, is characterized in that, under concrete steps:
(1), under stirring condition, 50-100g chitosan being dissolved in 20-40L concentration is in 1% (v/v) acetic acid solution; Then, use distilled water diluting chitosan solution, make its ultimate density be 2mg/ml; The pH value regulating chitosan solution with 1M sodium hydroxide solution is 6;
(2) Fructus Lycii extract, Ganoderma extract and Folium Ginkgo extract are slowly joined in order in chitosan solution, ultrasonic power is 450W, working time 20s, intermittent time 15s, works 90 times, obtains embedding suspension;
(3) adopt spray drying technology, obtain microspherulite diameter at the microsphere of 10-150 μm.
5. the capsule with enhancing immunity function chitosan complex prepared containing claim 4 method.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111758421A (en) * | 2020-06-02 | 2020-10-13 | 中山大学 | Application of rice metabolite beta-D-glucan in identification of resistance of rice to rice planthoppers |
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Address after: 266000 Songling Road 333 Laoshan District, Qingdao City, Shandong Province Applicant after: Yihai Industry Holding Co., Ltd. Address before: 266000 Songling Road 333 Laoshan District, Qingdao City, Shandong Province Applicant before: Qingdao Silver Century Health Industry Group Co., Ltd. |
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Application publication date: 20151209 |