CN106420399A - Laser cosmetology nursing agent, preparation and use method thereof - Google Patents

Laser cosmetology nursing agent, preparation and use method thereof Download PDF

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Publication number
CN106420399A
CN106420399A CN201611027888.3A CN201611027888A CN106420399A CN 106420399 A CN106420399 A CN 106420399A CN 201611027888 A CN201611027888 A CN 201611027888A CN 106420399 A CN106420399 A CN 106420399A
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China
Prior art keywords
acid
nursing agent
molecular
esters
hyaluronate
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CN201611027888.3A
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Chinese (zh)
Inventor
赵永亮
王卫国
解邦杰
靳松峰
林强
胡晓伟
陶宜辰
王丽洁
苑旺
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Henan University of Technology
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Henan University of Technology
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Priority to CN201611027888.3A priority Critical patent/CN106420399A/en
Publication of CN106420399A publication Critical patent/CN106420399A/en
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/884—Sequential application

Abstract

The invention discloses a laser cosmetology nursing agent, a preparation and a use method thereof. The nursing agent is composed of a No.1 nursing agent and a No.2 nursing agent, wherein the No.1 nursing agent has the main functions of resisting infection, relieving swelling and pain and preventing scar and chromatosis and is suitable for the short-term treatment before the operation, in the operation and after the operation; the No.2 nursing agent not only can supplement nutrition to the skin but also can prevent repigmentation and repair scar; the preparation for smoothing the skin can be applied to the affected part and also can be used for facial care. The laser cosmetology nursing agent provided by the invention not only can be used for effectively relieving and treating the symptoms, including inflammation, infection, phlogosis, pruritus, dry skin, chromatosis, photaesthesia, and the like, of the skin occurring after the cosmetology, such as, laser beautifying and glycolic peeling but also can be used for long-term nursing the face. The nursing agent is nontoxic, simulation-free and allergen-free, has convenience in use and is wide in application scope. The preparation method of the nursing agent has the advantages of mild condition, no temperature rise, low energy consumption, short technological process and no pollution. The preparation method is a green preparation technique worthy of popularization.

Description

A set of laser beautifying art nursing agent and its preparation and using method
Technical field
The invention belongs to cosmetics and technical field of medicine, relate in particular to a set of laser beautifying art nursing agent and Its preparation and using method.
Background technology
With the raising of people's living standard, the quickening of rhythm of life, the increasing of operating pressure, and environmental pollution etc. are asked The aggravation of topic and the reason such as self health status are not good enough, the skin health conditions of people get more and more.Skin abnormality, mottle such as passeris montani saturati The dyschromicum dermatosis patient such as speckle, black speck, chloasma and senile plaque is more and more universal.In order to reduce or reduce these obstacles The incidence rate of dermatoses patient, people are being carried out extensively always in fields such as life sciences, medical science, pharmacy and medical cosmetologies General in-depth study, the product of research and development listing or technical method are also varied.In many technical fields, medical shaping and beauty Technology is a dark horse, and quickly grows, the market demand is vigorous.Wherein, with fastest developing speed laser beautifying technology should be belonged to.Laser beautifying skill Art is a kind of emerging beautifying technique of rising in recent years because of the effective effect substantially, got instant result for welcomed by the people. It is to act on tissue by the high-energy that laser produces and produce high heat thus reaching removal or destroying mesh in local The purpose of mark tissue.By laser beautifying art really can eliminate mottle and skin surface vegetation and improve blee dark and gloomy, Pigmentation, cutis laxa, wrinkle, eye pouch are sagging, the skin abnormality problem such as black eye, pachylosiies, but laser was being treated Easy skin ambustion and leave permanent cicatrix in journey, can damage skin normal configuration cutaneous normal physiological work( Energy.Relevant report shows, laser surgery all can cause different degrees of damage to the epidermis of skin, corium and skin accessory organ Wound, thus cutaneous barrier, moisturizing, antiinflammatory and the function such as sun-proof further, skin can therefore become to be dried sensitive as be afraid of Light etc., easily infection etc..Meanwhile, note also postoperative long-term maintenance and sun-proof.As can be seen here, laser beautifying Peri-operative nursing Importance.
For making up defect or the deficiency of laser beautifying art, patent CN1337270A discloses wound dressing and its preparation side Method, main including collagen and its derivant in formula, and hyaluronic acid or derivatives thereof, use first in formula The mixture of type, the first type or the 3rd collagen type or the mixture of other different collagen types.Although biocompatibility Good, but it is insoluble in water, its Transdermal absorption performance is bad, and its cosmetic result has much room for improvement, particularly its nourishing effect to skin corium Really limited；And there is easily contaminated situation, good desensitization can not be reached for the sensitive skin after laser operation and repair effect Really.CN 104474577 B discloses a kind of postoperative dressing of laser beautifying and preparation method, and its high temperature sterilize operating procedure will make Its active ingredient loss is serious；CN 105662916 A discloses a kind of sebum film remediation composition, and it falls within high-temperature operation Technique；CN 105477342 A discloses a kind of Chinese medicine maintenance frost postoperative for laser beautifying and preparation method thereof, and it is not only Need high-temperature operation, and technique is considerably complicated, yield is low not to be said, because it adopts miscellaneous natural Chinese medicine component and right Its issuable side effect or ill effect are difficult to expect.Importantly, above-mentioned several technical products, including being seen in report Other classic products, all only apply to the nursing after laser surgery, and be all single product or preparation.And it is beautiful for laser Hold, nursing no less important postoperative in preoperative art, and in preoperative art with postoperative and postoperative short-term and long-term nursing content Different, also should difference for the product of nursing.The suit of postoperative care be applied to the preoperative art of laser beautifying Or combination technique or product have not been reported.
Content of the invention
For solving deficiency or the defect of above-mentioned technology or product, the invention provides a set of laser beautifying art nursing agent and its Preparation method.This nursing agent is made up of nursing agent 1 and nursing agent 2, and the major function that nursing agent 1 has been infection detumescence Effect that pain relieving and anti-cicatrix, anti-color sink is it is adaptable to the process with postoperative short-term in preoperative art；Nursing agent 2 is that one kind both may be used Supplement nutrient to skin, pigment regeneration can be prevented again and repair cicatrix, make skin bright and clean beautiful（The i.e. light scar whitening of light speckle）System Agent, it is a kind of preparation that can be used for facial-care for a long time, cannot be only used for affected part, also can entirely smear face.
The basic ideas of the present invention are, by laser beautifying art to the epidermis of common skin, corium and skin appendages The analysis of the reason official and skin physiology function cause damage and feature and research, find that postoperative nursing in preoperative art is equally heavy Will, or even the nursing in preoperative art is more important, it can effectively reduce the risk of laser beautifying art and the difficulty of postoperative care, base Both needed anti-infection reducing swelling and alleviating pain in patient, the theory laid equal stress on nutrition or reparation with greater need for nutrition and reparation, anti-infection detumescence, Design a kind of nursing agent 1 that there is infection reducing swelling and alleviating pain and have nutrition and reparation effect concurrently first, then redesign a kind of With nutrition with repair based on effect and have the antianaphylactic nursing agent of anti-infection 2 concurrently, and the principle based on safety first position, 2 The screening of kind of preparation raw material is all to act on and belong to biogenic or biochemical class, food-borne from having nutrition and health care to skin , component based on the component of clear efficacy, with sorbic acid and its esters, the Radix Glycyrrhizae time with broad-spectrum high efficacy safety generally acknowledged Acid, glycyrrhizic acid and its esters, allantoin, lactic acid, lactate, malic acid, tartaric acid, citric acid and salicylic acid and its esters etc. are made For anti-infection antianaphylaxis components, with cell, different material is absorbed according to skin histology or pass through the understanding of rule characteristic and divide Analysis, in the case of without tradition tool toxic and side effects or dripping of irritant drugs, will have nourishing healthy and the anti-mistake of anti-infection to skin The biogenic of quick effect or biochemical class component carry out science and assemble the anti-infection of energy again of not only can having protected skin nutrition of one group of optimization The compositionss of antianaphylactic safe multiple-effect, further according to selected component characteristic using a kind of gentle technology method system Become the laser beautifying art nursing agent dosage form of Energy and comfort.
The present invention is realized in：
The present invention provides a set of laser beautifying art nursing agent.The laser beautifying art nursing agent of the present invention is by nursing agent 1 and shield No. 2 compositions of reason agent, wherein, described nursing agent 1 contains sorbic acid and its esters, enoxolone, glycyrrhizic acid and its esters, cattle Sulfonic acid, allantoin, lactic acid, lactate, malic acid, tartaric acid, citric acid and salicylic acid and its esters, aspirin, smart ammonia Arbitrary or a combination thereof in sour aspirin, lysine acetylsalicylate, calcium acetylsalicylate urea, high, normal, basic three kinds of different moleculars The hyaluronic acid of amount size or/and hyaluronate, the polyglutamic acid of high, normal, basic three kinds of different molecular weight sizes or/and polyglutamic Hydrochlorate, glutamic acid or/and glutamate, Glu, collagen peptide, L-Glutamine, nicotinic acid, nicotiamide, chondroitin sulfate, heparin sodium, sea Algae sugar, xylitol, shitosan, sodium alginate, xanthan gum, polyethylene glycol component；Described nursing agent 2 contain L-Glutamine, The hyaluronic acid of high, normal, basic three kinds of different molecular weight sizes or/and hyaluronate, high, normal, basic three kinds of different molecular weight sizes Polyglutamic acid or/and polyglutamate, glutamic acid or/and glutamate, Glu, collagen peptide, Vc, Ve, Vb5, nicotinic acid, nicotiamide, Nadide, coenzyme II, chondroitin sulfate, taurine, heparin sodium, ubiquinone10, trehalose, sorbic acid and its esters, glycyrrhizic acid and its Salt, allantoin, malic acid, citric acid and salicylic acid and its esters, sodium alginate, xanthan gum, PEG component；Prepare nursing agent 1 Number and solvent used by nursing agent 2 be purified water；In the case of without tradition tool toxic and side effects or dripping of irritant drugs, will Said components and solvent carry out science and assemble and optimize, then are made into Energy and comfort using a kind of gentle technology method Laser beautifying art nursing agent dosage form.Laser beautifying art nursing agent of the present invention is easy to use comfortable, effect is significant, and preparation technology The simple simultaneously environmental sound of technical method.
Wherein, described nursing agent 1 is by following mass percent（%）Raw material composition：Sorbic acid or/and its esters 0.001-4.0, enoxolone 0.001-4.0, glycyrrhizic acid or/and its esters 0.001-4.0, taurine 0.01-5.0, allantoin 0.01-5.0, lactic acid 0.01-5.0, lactate 0.01-5.0, citric acid 0.01-5.0, malic acid 0.01-8.0, tartaric acid 0.01-8.0 and salicylic acid or/and its esters 0.001-6.0, aspirin 0.001-5.0, Arginine Acetylsalicylate Arbitrary or a combination thereof in 0.002-3.0, lysine acetylsalicylate 0.002-4.0, calcium acetylsalicylate urea 0.002-4.0；High The hyaluronic acid of molecular weight or/and hyaluronate 0.1-5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1- 8.0th, the hyaluronic acid of low-molecular-weight or/and hyaluronate 0.1-10.0, the polyglutamic acid of high molecular or/and polyglutamic acid Salt 0.1-4.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-6.0, the polyglutamic acid of low-molecular-weight or/and poly- Glutamate, Glu 0.1-12.0, glutamic acid or/and glutamate, Glu 0.01-10.0, collagen peptide 0.01-8.0, L-Glutamine 0.01-6.0, nicotinic acid 0.01-5.0, nicotiamide 0.01-8.0, chondroitin sulfate 0.01-5.0, heparin sodium 0.01-5.0, trehalose 0.01-9.0, xylitol 0.01-6.0, shitosan 0.01-8.0, sodium alginate 0.01-9.0, xanthan gum 0.01-9.0, poly- second two Alcohol 0.0001-15.0 and solvent：Surplus；
Described nursing agent 2 comprises following mass fraction（Part）Raw material：L-Glutamine 0.01-8.0, high molecular saturating Bright matter acid or/and hyaluronate 0.1-5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1-8.0, low molecule Amount hyaluronic acid or/and hyaluronate 0.1-10.0, the polyglutamic acid of high molecular or/and polyglutamate 0.1-4.0, The polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-6.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1-12.0, glutamic acid or/and glutamate, Glu 0.01-10.0, collagen peptide 0.01-8.0, Vc 0.01-5.0, Ve 0.01- 5.0、Vb50.01-8.0, nicotinic acid 0.01-5.0, nicotiamide 0.01-5.0, nadide 0.01-2.0, coenzyme II 0.01-2.0, Chondroitin sulfate 0.01-5.0, taurine 0.01-5.0, heparin sodium 0.01-5.0, ubiquinone100.01-2.0, trehalose 0.01- 9.0th, sorbic acid or/and its esters 0.001-4.0, glycyrrhizic acid or/and its esters 0.001-4.0, allantoin 0.01-15.0, Herba Marsileae Quadrifoliae Fruit acid 0.01-8.0, citric acid 0.01-5.0 and salicylic acid or/and its esters 0.001-35.0, aspirin 0.001- 25.0th, sodium alginate 0.01-9.0, xanthan gum 0.01-9.0, Polyethylene Glycol 0.0001-15.0 and solvent：Surplus.
As a kind of optimal way of this laser beautifying art nursing agent, described nursing agent 1 is by following percent mass Than（%）Raw material composition：Sorbic acid or/and its esters 0.01-2.0, enoxolone 0.01-2.0, glycyrrhizic acid or/and its esters 0.01-2.0, taurine 0.05-4.0, allantoin 0.05-2.0, lactic acid 0.05-4.0, lactate 0.05-4.0, citric acid 0.05-3.0, malic acid 0.05-6.0, tartaric acid 0.05-6.0 and salicylic acid or/and its esters 0.01-4.0, aspirin 0.01-3.0, Arginine Acetylsalicylate 0.02-2.0, lysine acetylsalicylate 0.02-3.0, calcium acetylsalicylate urea 0.02- Arbitrary or a combination thereof in 3.0；The hyaluronic acid of high molecular or/and the hyalomitome of hyaluronate 0.1-3.0, middle-molecular-weihydroxyethyl Acid or/and hyaluronate 0.1-6.0, the hyaluronic acid of low-molecular-weight or/and hyaluronate 0.1-8.0, high molecular Polyglutamic acid or/and polyglutamate 0.1-3.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-5.0, low point The polyglutamic acid of son amount or/and polyglutamate 0.1-10.0, glutamic acid or/and glutamate, Glu 0.02-8.0, collagen peptide 0.05-6.0, L-Glutamine 0.05-5.0, nicotinic acid 0.1-3.0, nicotiamide 0.05-5.0, chondroitin sulfate 0.05-3.0, heparin Sodium 0.05-3.0, trehalose 0.05-7.0, xylitol 0.1-4.0, shitosan 0.1-5.0, sodium alginate 0.1-6.0, xanthan gum 0.1-6.0, Polyethylene Glycol 0.001-12.0 and solvent：Surplus；
Described nursing agent 2 comprises following mass fraction（Part）Raw material：L-Glutamine 0.05-5.0, high molecular saturating Bright matter acid or/and hyaluronate 0.1-3.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1-6.0, low molecule Amount hyaluronic acid or/and hyaluronate 0.1-8.0, the polyglutamic acid of high molecular or/and polyglutamate 0.1-3.0, The polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-5.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1-10.0, glutamic acid or/and glutamate, Glu 0.02-8.0, collagen peptide 0.05-6.0, Vc 0.05-3.0, Ve 0.02- 3.0、Vb50.05-6.0, nicotinic acid 0.1-3.0, nicotiamide 0.05-5.0, nadide 0.01-1.0, coenzyme II 0.01-1.0, sulfur Aching and limp ossein 0.05-3.0, heparin sodium 0.05-3.0, ubiquinone100.01-1.0, trehalose 0.05-7.0, sorbic acid or/and its Salt 0.01-2.0, glycyrrhizic acid or/and its esters 0.01-2.0, allantoin 0.05-2.0, malic acid 0.05-6.0, citric acid 0.05-3.0 and salicylic acid or/and its esters 0.01-4.0, aspirin 0.01-3.0, sodium alginate 0.1-6.0, xanthan gum 0.1-6.0, Polyethylene Glycol 0.001-12.0 and solvent：Surplus.
Except minority belongs to biological endogenous property or the derivant of biochemical class component in the laser beautifying art nursing agent component of the present invention Outward, other is biological endogenous property, food-borne, clear efficacy component, and wherein, some still constitute skin histology and thin The basis of born of the same parents, and, most components have multiple physiology/pharmacological functions or effect.As hyaluronic acid, polyglutamic Acid, collagen peptide, nadide, coenzyme II, chondroitin sulfate, taurine, heparin sodium, lactic acid, lactate and ubiquinone10It is Constitute the basis of skin histology and cell or maintain normal skin tissue and cell to carry out biogenic life Reason active component, meanwhile, they are also had defying age and are acted on improving skin immunity, antiallergic etc. with moisturizing, antioxidation； Vc、Ve、Vb5, nicotinic acid, nicotiamide, enoxolone, glycyrrhizic acid and its esters, allantoin, citric acid, malic acid, tartaric acid and water Poplar acid and its esters, aspirin, smart ammonia aspirin, lysine acetylsalicylate, calcium acetylsalicylate urea, then in antibacterial The aspects such as antiinflammatory, whitening, speckle dispelling are respond well, and each component is ingenious more significantly and rapid with the use of its repairing effect；Sargassum Sugar and sodium alginate have protection Skin Cell and radiation-resistant function under adverse circumstance；Xanthan gum then has good thickening, attachment And lubrication；Sorbic acid and its esters are well recognized as safe food-level antibacterial preservative, are conducive to keeping the steady for a long time of product Qualitative and quality.According to the feature needing nursing content in selected component characteristic and function and laser beautifying art, by above-mentioned group Point carrying out science assembles and can be made into laser beautifying art nursing agent No. 1 and No. 2 with certain technology method.
The hyaluronic acid of the high, normal, basic three kinds of different molecular weight sizes in laser beautifying art nursing agent of the present invention Or/and hyaluronate refers to that the molecular weight of polymer hyaluronic acid or hyaluronate is more than 1,800,000 dalton, in point The molecular weight of sub- hyaluronic acid or hyaluronate between 1,000,000-1,800,000 dalton, low molecule hyalomitome The molecular weight of acid or hyaluronate is less than 600,000 dalton.
The polyglutamic acid of described high, normal, basic three kinds of different molecular weight sizes or/and polyglutamate refer to macromolecule polyglutamic The molecular weight of acid or polyglutamate is more than 1,000,000 dalton, the molecular weight of middle molecule polyglutamic acid or polyglutamate Between 600,000-1,000,000 dalton, the molecular weight of low molecular weight polycaprolactone glutamic acid or polyglutamate is less than 100,000 Dalton.
Described Polyethylene Glycol refers to that the molecular weight of more than food stage is any one in 400-20000 dalton or its group Close.
Described aqueous solvent is the above pure water of reverse osmosiss level or its distilled water.
In the laser beautifying art nursing agent of the present invention, all components are the product of more than commercially available food stage or medical grade Product.
The laser beautifying art nursing agent dosage form of Energy and comfort of the present invention includes liquid formulation and solid formulation, preferably Half fluidised form preparation, more preferably aqueous gel；In practical application, can as needed and use Energy and comfort, With in described laser beautifying art nursing agent, composition in addition to the solvents is as base material, then mixes laser beautifying art nursing agent of the present invention Acceptable safe carrier or adjuvant, make the convenient various dosage forms being suitable for using corresponding preparations technology, can be water preparation, wine Agent, tincture, suspension, emulsion, cream, unguentum, gel, coagulant liquid, oil preparation, membrane, spray or patch etc..
Present invention also offers the preparation method of above-mentioned laser beautifying art nursing agent, comprise the steps：
（1）Formula as described in this patent and formula ratio weigh each component of nursing agent 1 respectively, standby；
（2）Formula as described in this patent and formula ratio weigh each component of nursing agent 2 respectively, standby；
（3）Add the solvent of part formulation amount, room temperature or low temperature to mix in each component of nursing agent 1, treat completely After dissolving, add balance solvent, continuing to stir can be prepared by nursing agent 1；
（4）Add the solvent of part formulation amount, room temperature or low temperature to mix in each component of nursing agent 2, treat completely After dissolving, add balance solvent, continuing to stir can be prepared by nursing agent 2.
Step（3）（4）Described in room temperature or cryogenic conditions be preferably less than 46 DEG C, again more preferably less than 30 DEG C but be more than 15℃.
Step（3）（4）Described in stirring and evenly mixing operating condition be preferably two dimension in medical stainless steel blender and mix Close stirring, the three-dimensional hybrid stirring more preferably in glass reactor or 316L stainless steel blender, is further preferably in vacuum Under the conditions of emulsifying mode realize.
In practical operation, can as needed and use Energy and comfort, with above-mentioned laser beautifying art nursing agent For base material, then mix laser beautifying art nursing agent acceptable carrier of the present invention or adjuvant, using corresponding preparations technology system Become the convenient various dosage forms being suitable for.
Using method：Nursing agent 1：Preoperative smear affected part, postoperative smear affected part immediately again；According to feelings in postoperative 2 weeks Condition can multiplex daily several times.Smear 1-3 time daily later, until wound healing（Or decrustation skin）Afterwards；Then use laser beautifying Art nursing agent 2；Nursing agent 2：First apply affected part, repaste face other position.Daily each 1 time sooner or later.Nursing agent 2 is a kind of The preparation of affected part and facial-care can be used for for a long time.
The present invention has following features with conventional laser cosmesiss care product or method compared with technology：
（1）Conventional laser cosmesiss care product is only applicable to postoperative care and mostly single product, and the nursing agent of the present invention is Suit, is laser beautifying art whole range nursing agent, both can be suitably used for the nursing in preoperative art, and can be suitably used for postoperative nursing again；
（2）On laser beautifying art nursing agent raw material components select, based on the consideration of safety first principle, skin used by the present invention Skin maintenance raw material is biological endogenous property, biochemical class, food-borne, clear efficacy component, and wherein, some are still constituted Skin histology and the basis of cell, and, most components have multiple physiology/pharmacological functions and skin are had good Good protective effect.So, both provide enough nutrition for skin tissue cell, have the function of multiple protective skin again；
（3）It is based on and should nurse skin friendly again or toxic and side effects or irritating principle not produced to body or skin, Nursing raw material components select, and have abandoned traditional organic solvent and medicine material, but sieve the raw material more than food stage Select that one group of existing disinfecting, antimicrobial is antibacterial and alleviating pain and detumescence, have reparation damaged tissues, also promising skin provides desired nutritional again Composition, the efficient combination of three can produce good laser beautifying art nursing role；
（4）The preparation method mild condition of laser beautifying art nursing agent of the present invention, process is simple, non-environmental-pollution.Due to this Bright raw materials used mostly be biochemical class component, more sensitive to physical and chemical factors such as high temperature and illumination, so, by component preferably and work Skill optimizes, and establishes and a kind of can prepare the process is simple, no of laser beautifying art nursing agent of the present invention under room temperature or low temperature The technical method of environmental pollution.
Long-term result of practical application shows, the present invention has the advantages that in a large number：
（1）Nursing is convenient, and hurtless measure no pain is non-stimulated.In the formula of this laser beautifying art nursing agent, containing multiple foster skins shield Skin composition such as hyaluronic acid, vitamin etc. it is ensured that in postoperative in art in the preoperative nursing skin friendly and will not to body or Skin produces toxic and side effects；
（2）Easy to use, excellent effect.Only infection can be played with nursing agent 1 with the process of postoperative short-term in preoperative art to disappear The effect that swollen pain relieving and anti-cicatrix, anti-color sink；Nursing agent 2 is that one kind both can supplement nutrient to skin, can prevent pigment more again Life and reparation cicatrix, make skin bright and clean beautiful（The i.e. light scar whitening of light speckle）Preparation, it be one kind can be used for for a long time face shield The preparation of reason, cannot be only used for affected part, also can entirely smear face；Nursing agent of the present invention can not only effectively be alleviated and treat warp Redness caused by skin after laser beautifying, fruit acid change the beauty treatment means such as skin, infection, inflammation, burning pain, desquamation, prurituss, skin are done The dry, symptom such as pigmentation, photophobia, and can be additionally used in the long-term care of face；Change skin, micro-shaping through facial laser, fruit acid The damaged skin causing Deng the skin after invasive surgery and the reason such as sensitive skin, dermatitis all can use nursing agent of the present invention；
（3）Safe, widely applicable.Laser beautifying art nursing agent of the present invention is nontoxic, non-stimulated, no allergy, easy to use, fits For nearly all crowd；
（4）Simple production process, production cost is relatively low；
（5）The preparation method mild condition of laser beautifying art nursing agent of the present invention, need not heat up, energy consumption low, technological process is short, and Non-environmental-pollution, is a kind of green manufacture technology being worthy to be popularized.
The trial effect of people volunteer is as follows：
（1）Case selection：Random selection need to do the dermatosis patient 108 of the invasive surgeries such as laser beautifying art, and wherein, male 48 Example, women 114, age 18-65 year, 38 years old mean age.It is randomly divided into 3 groups：A group test group, B group is tested Group, C group matched group；Every group of 54 people.
（2）Health giving quality index：Carry out symptom score with reference to face sensitivity dermatitis standard：Redness, prurituss, erythema, edema, ooze Go out, be dried desquamation, twinge, pigmentation respectively by no, light, in, restatement be 03 points.
（3）Therapeutic Method：A group and B group patient use nursing agent of the present invention, nursing agent 1：Preoperative smear affected part, postoperative Smear affected part immediately again；According to circumstances can overbrushing be several times daily in postoperative 2 weeks.Smear 1-3 time daily later, until wound Healing（Or decrustation skin）Afterwards；Then use laser beautifying art nursing agent 2；Nursing agent 2：First apply affected part, repaste facial other portion Position.Daily each 1 time sooner or later, smear altogether 2 months.Chlortetracycline or erythromycin ointment, access times and AB group is smeared after C group operation in patients Identical, until wound heals completely.Other any nursing products or cosmetics are disabled during test.
（4）Curative effect judging standard：According to symptom, somatic feature score before and after treatment, reference《New Chinese medicine clinical research is instructed former Then》, carry out therapeutic evaluation by following standard：
Recovery from illness:Symptom, somatic feature score reduce >=95%.
Effective:Symptom, somatic feature score reduce >=70%,<95%.
Effectively:Symptom, somatic feature score reduce >=30%,<70%.
Invalid:Symptom, sign reduce less than 30%.
Recovery from illness+effective+effective number of cases calculates total effective rate.
Computing formula is：[integration before (integrating after integration-treatment before treatment)/treatment] × 100%.
（5）Therapeutic outcome：In test group 108, fully recover 66, effective 34, effective 6, invalid 2, cure rate 61.1%, obvious effective rate 31.5%, effective percentage 5.6%, inefficiency 1.8%, total effective rate 98.2%, exceed 38.0% than matched group.In addition, Untoward reaction rate after the repair time of anti-infection property and moisture retention and wound surface and use, test group is also significantly better than comparison Group.
Specific embodiment
With reference to embodiment, the present invention is described in detail：
Embodiment l：
Formula：Nursing agent 1 is by following mass percent（%）Raw material composition：Sorbic acid or/and its esters 1.5, enoxolone 0.8th, glycyrrhizic acid or/and its esters 2.5, taurine 3.5, allantoin 0.6, lactic acid 2.5, lactate 2.5, citric acid 1.8, Fructus Mali pumilae Acid 4.5, tartaric acid 2.5 and salicylic acid or/and its esters 4.5, aspirin 1.5, Arginine Acetylsalicylate 1.5, bad ammonia Sour aspirin 1.8, calcium acetylsalicylate urea 2.5；The hyaluronic acid of high molecular or/and hyaluronate 1.5, middle-molecular-weihydroxyethyl Hyaluronic acid or/and hyaluronate 4.5, the hyaluronic acid of low-molecular-weight or/and hyaluronate 6.5, high molecular Polyglutamic acid or/and polyglutamate 1.2, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 3.8, low-molecular-weight poly- Glutamic acid or/and polyglutamate 8.5, glutamic acid or/and glutamate, Glu 7.8, collagen peptide 5.8, L-Glutamine 4.5, cigarette Acid 2.5, nicotiamide 4.6, chondroitin sulfate 1.5, heparin sodium 1.5, trehalose 5.5, shitosan 2.5, xylitol 3.9, alginic acid Sodium 5.6, xanthan gum 3.8, Macrogol 1000 3.9 and solvent：Surplus；
Nursing agent 2 comprises following mass fraction（Part）Raw material：L-Glutamine 7.0, the hyaluronic acid of high molecular or/and Hyaluronate 0.2, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.5, the hyaluronic acid of low-molecular-weight or/and thoroughly Bright matter hydrochlorate 3.5, the polyglutamic acid of high molecular or/and polyglutamate 0.8, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and poly- paddy Propylhomoserin salt 1.2, the polyglutamic acid of low-molecular-weight or/and polyglutamate 8.8, glutamic acid or/and glutamate, Glu 0.5, collagen egg White peptide 3.9, Vc 2.5, Ve 0.8, Vb54.8th, nicotinic acid 1.8, nicotiamide 4.6, nadide 0.5, coenzyme II 0.5, chondroitin sulfate Element 2.5, taurine 3.8, heparin sodium 1.6, ubiquinone100.8th, trehalose 6.5, sorbic acid or/and its esters 1.8, glycyrrhizic acid or/ With its esters 2.5, allantoin 0.5, malic acid 4.6, citric acid 2.5 and salicylic acid or/and its esters 1.2, aspirin 2.5th, sodium alginate 0.8, xanthan gum 0.6, Macrogol 1000 3.5 and solvent：Surplus；
Preparation method：Comprise the steps of：
（1）Formula as described in this patent and formula ratio weigh each component of nursing agent 1 respectively, standby；
（2）Formula as described in this patent and formula ratio weigh each component of nursing agent 2 respectively, standby；
（3）Add the solvent of part formulation amount, room temperature or low temperature to mix in each component of nursing agent 1, treat completely After dissolving, add balance solvent, continuing to stir can be prepared by nursing agent 1；
（4）Add the solvent of part formulation amount, room temperature or low temperature to mix in each component of nursing agent 2, treat completely After dissolving, add balance solvent, continuing to stir can be prepared by nursing agent 2.
Embodiment 2：
Formula：Nursing agent 1 is by following mass percent（%）Raw material composition：Sorbic acid or/and its esters 0.1, enoxolone 0.001st, glycyrrhizic acid or/and its esters 0.001, taurine 0.01, allantoin 0.01, lactic acid 0.01, lactate 0.01, citric acid 0.01st, malic acid 0.01, tartaric acid 0.01 and salicylic acid or/and its esters 0.001, aspirin 0.5, arginine acetyl water Poplar acid 0.002, lysine acetylsalicylate 0.002；The hyaluronic acid of high molecular or/and hyaluronate 0.1, middle-molecular-weihydroxyethyl Hyaluronic acid or/and hyaluronate 0.1, the hyaluronic acid of low-molecular-weight or/and hyaluronate 0.1, high molecular Polyglutamic acid or/and polyglutamate 0.1, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1, low-molecular-weight poly- Glutamic acid or/and polyglutamate 0.1, glutamic acid or/and glutamate, Glu 0.01, collagen peptide 0.01, L-Glutamine 0.01st, nicotinic acid 0.01, nicotiamide 0.01, chondroitin sulfate 0.01, heparin sodium 0.01, trehalose 0.01, xylitol 0.01, shell gather Sugar 0.01, sodium alginate 0.01, xanthan gum 0.01, PEG 20000 0.0001 and solvent：Surplus；
Nursing agent 2 comprises following mass fraction（Part）Raw material：L-Glutamine 0.01, the hyaluronic acid of high molecular or/and Hyaluronate 0.1, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1, the hyaluronic acid of low-molecular-weight or/and thoroughly Bright matter hydrochlorate 0.1, the polyglutamic acid of high molecular or/and polyglutamate 0.1, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and poly- paddy Propylhomoserin salt 0.1, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1, glutamic acid or/and glutamate, Glu 0.01, collagen egg White peptide 0.01, Vc 0.01, Ve 0.01, Vb50.01st, nicotinic acid 0.01, nicotiamide 0.01, nadide 0.01, coenzyme II 0.01, Chondroitin sulfate 0.01, taurine 0.01, heparin sodium 0.01, ubiquinone100.01st, trehalose 0.01, sorbic acid or/and its esters 0.05th, glycyrrhizic acid or/and its esters 0.001, allantoin 0.01, malic acid 0.01, citric acid 0.01 and salicylic acid or/and its salt Class 0.001, aspirin 0.3, sodium alginate 0.01, xanthan gum 0.01, PEG 20000 0.0001 and solvent：Remaining Amount；
Preparation method：With embodiment 1.
Embodiment 3：
Formula：Nursing agent 1 is by following mass percent（%）Raw material composition：Sorbic acid or/and its esters 0.001, Radix Glycyrrhizae time Acid 4.0, glycyrrhizic acid or/and its esters 4.0, taurine 5.0, allantoin 5.0, lactic acid 5.0, lactate 5.0, citric acid 5.0, Herba Marsileae Quadrifoliae Fruit acid 8.0, tartaric acid 8.0 and salicylic acid or/and its esters 6.0, aspirin 0.001, Arginine Acetylsalicylate 3.0； The hyaluronic acid of high molecular or/and hyaluronate 5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 8.0, low The hyaluronic acid of molecular weight or/and hyaluronate 10.0, the polyglutamic acid of high molecular or/and polyglutamate 4.0, in point The polyglutamic acid of son amount or/and polyglutamate 6.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 12.0, glutamic acid Or/and glutamate, Glu 10.0, collagen peptide 8.0, L-Glutamine 6.0, nicotinic acid 5.0, nicotiamide 8.0, chondroitin sulfate 5.0, Heparin sodium 5.0, trehalose 9.0, xylitol 6.0, shitosan 8.0, sodium alginate 9.0, xanthan gum 9.0, PEG400 15.0 and solvent：Surplus；
Nursing agent 2 comprises following mass fraction（Part）Raw material：L-Glutamine 8.0, the hyaluronic acid of high molecular or/and Hyaluronate 5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 8.0, the hyaluronic acid of low-molecular-weight or/and thoroughly Bright matter hydrochlorate 10.0, the polyglutamic acid of high molecular or/and polyglutamate 4.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and poly- paddy Propylhomoserin salt 6.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 12.0, glutamic acid or/and glutamate, Glu 10.0, collagen Protein peptide 8.0, Vc 5.0, Ve 5.0, Vb58.0th, nicotinic acid 5.0, nicotiamide 5.0, nadide 2.0, coenzyme II 2.0, sulphuric acid soft Ossein 5.0, taurine 5.0, heparin sodium 5.0, ubiquinone102.0th, trehalose 9.0, sorbic acid or/and its esters 0.001, glycyrrhizic acid Or/and its esters 4.0, allantoin 15.0, malic acid 8.0, citric acid 5.0 and salicylic acid or/and its esters 35.0, acetyl salicylic Acid 0.001, sodium alginate 9.0, xanthan gum 9.0, PEG400 15.0 and solvent：Surplus；
Preparation method：With embodiment 1.
Embodiment 4：
Formula：Nursing agent 1 is by following mass percent（%）Raw material composition：Sorbic acid or/and its esters 1.0, enoxolone 0.5th, glycyrrhizic acid or/and its esters 0.5, taurine 1.0, allantoin 0.5, lactic acid 1.0, lactate 1.0, citric acid 1.0, Fructus Mali pumilae Acid 2.0, tartaric acid 2.0 and salicylic acid or/and its esters 0.6, aspirin 5.0；The hyaluronic acid of high molecular or/and thoroughly Bright matter hydrochlorate 0.5, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 1.0, the hyaluronic acid of low-molecular-weight or/and transparent Matter hydrochlorate 2.0, the polyglutamic acid of high molecular or/and polyglutamate 1.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamic Hydrochlorate 1.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 3.0, glutamic acid or/and glutamate, Glu 3.0, collagen protein Peptide 2.0, L-Glutamine 1.0, nicotinic acid 1.0, nicotiamide 1.0, chondroitin sulfate 1.0, heparin sodium 1.0, trehalose 1.0, xylitol 1.0th, shitosan 0.5, sodium alginate 2.0, xanthan gum 2.0, polyethylene glycol 6000 0.5 and solvent：Surplus；
Nursing agent 2 comprises following mass fraction（Part）Raw material：L-Glutamine 1.0, the hyaluronic acid of high molecular or/and Hyaluronate 1.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 2.0, the hyaluronic acid of low-molecular-weight or/and thoroughly Bright matter hydrochlorate 3.0, the polyglutamic acid of high molecular or/and polyglutamate 0.5, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and poly- paddy Propylhomoserin salt 1.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 1.0, glutamic acid or/and glutamate, Glu 2.0, collagen egg White peptide 1.0, Vc 1.0, Ve 1.0, Vb51.0th, nicotinic acid 0.5, nicotiamide 1.0, nadide 0.1, coenzyme II 0.2, chondroitin sulfate Element 1.0, taurine 1.0, heparin sodium 1.0, ubiquinone100.1st, trehalose 1.0, sorbic acid or/and its esters 4.0, glycyrrhizic acid or/ With its esters 0.1, allantoin 3.0, malic acid 1.0, citric acid 1.0 and salicylic acid or/and its esters 1.0, aspirin 25.0th, sodium alginate 2.0, xanthan gum 2.0, polyethylene glycol 6000 3.0 and solvent：Surplus；
Preparation method：With embodiment 1.
Embodiment 5：
Formula：Nursing agent 1 is by following mass percent（%）Raw material composition：Sorbic acid or/and its esters 2.0, enoxolone 1.0th, glycyrrhizic acid or/and its esters 2.0, taurine 2.0, allantoin 2.0, lactic acid 2.0, lactate 2.0, citric acid 2.0, Fructus Mali pumilae Acid 3.0, tartaric acid 3.0 and salicylic acid or/and its esters 2.0；The hyaluronic acid of high molecular or/and hyaluronate 3.0, in The hyaluronic acid of molecular weight or/and hyaluronate 5.0, the hyaluronic acid of low-molecular-weight or/and hyaluronate 7.0, high score The polyglutamic acid of son amount or/and polyglutamate 2.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 4.0, low molecule The polyglutamic acid of amount or/and polyglutamate 8.0, glutamic acid or/and glutamate, Glu 7.0, collagen peptide 5.0, L-Glutamine 4.0th, nicotinic acid 3.0, nicotiamide 5.0, chondroitin sulfate 3.0, heparin sodium 3.0, trehalose 6.0, xylitol 4.0, shitosan 5.5, Sodium alginate 6.0, xanthan gum 5.0, PEG20000 10.0 and solvent：Surplus；
Nursing agent 2 comprises following mass fraction（Part）Raw material：L-Glutamine 4.0, the hyaluronic acid of high molecular or/and Hyaluronate 3.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 5.0, the hyaluronic acid of low-molecular-weight or/and thoroughly Bright matter hydrochlorate 7.0, the polyglutamic acid of high molecular or/and polyglutamate 2.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and poly- paddy Propylhomoserin salt 4.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 8.0, glutamic acid or/and glutamate, Glu 5.0, collagen egg White peptide 5.0, Vc 3.0, Ve 3.0, Vb55.0th, nicotinic acid 3.0, nicotiamide 3.0, nadide 1.0, coenzyme II 1.0, chondroitin sulfate Element 3.0, taurine 3.0, heparin sodium 3.0, ubiquinone101.0th, trehalose 6.0, sorbic acid or/and its esters 2.0, glycyrrhizic acid or/ With its esters 2.0, allantoin 10.0, malic acid 5.0, citric acid 3.0 and salicylic acid or/and its esters 25.0, aspirin 15.0th, sodium alginate 5.0, xanthan gum 6.0, PEG20000 12.0 and solvent：Surplus；
Preparation method：With embodiment 1.
The invention is not restricted to case study on implementation described above.

Claims (9)

1. a set of laser beautifying art nursing agent it is characterised in that：This laser beautifying art nursing agent is by nursing agent 1 and nursing No. 2 compositions of agent, wherein, described nursing agent 1 contains sorbic acid and its esters, enoxolone, glycyrrhizic acid and its esters, cattle sulphur Acid, allantoin, lactic acid, lactate, malic acid, tartaric acid, citric acid and salicylic acid and its esters, aspirin, arginine Arbitrary or a combination thereof in aspirin, lysine acetylsalicylate, calcium acetylsalicylate urea, high, normal, basic three kinds of different molecular weights The hyaluronic acid of size or/and hyaluronate, the polyglutamic acid of high, normal, basic three kinds of different molecular weight sizes or/and polyglutamic acid Salt, glutamic acid or/and glutamate, Glu, collagen peptide, L-Glutamine, nicotinic acid, nicotiamide, chondroitin sulfate, heparin sodium, Sargassum Sugar, xylitol, shitosan, sodium alginate, xanthan gum, polyethylene glycol component；Described nursing agent 2 contains L-Glutamine, height In the hyaluronic acid of low three kinds of different molecular weight sizes or/and hyaluronate, high, normal, basic three kinds of different molecular weight sizes poly- Glutamic acid or/and polyglutamate, glutamic acid or/and glutamate, Glu, collagen peptide, Vc, Ve, Vb5, nicotinic acid, nicotiamide, auxiliary Enzyme I, coenzyme II, chondroitin sulfate, taurine, heparin sodium, ubiquinone10, trehalose, sorbic acid and its esters, glycyrrhizic acid and its salt Class, allantoin, malic acid, citric acid and salicylic acid and its esters, sodium alginate, xanthan gum, PEG component；Prepare nursing agent 1 It is purified water with the solvent used by nursing agent 2；In the case of without tradition tool toxic and side effects or dripping of irritant drugs, will be upper State component and solvent carries out science and assembles and optimize, then Energy and comfort is made into using a kind of gentle technology method Laser beautifying art nursing agent dosage form；
Wherein, described nursing agent 1 is by following mass percent（%）Raw material composition：Sorbic acid or/and its esters 0.001-4.0, enoxolone 0.001-4.0, glycyrrhizic acid or/and its esters 0.001-4.0, taurine 0.01-5.0, allantoin 0.01-5.0, lactic acid 0.01-5.0, lactate 0.01-5.0, citric acid 0.01-5.0, malic acid 0.01-8.0, tartaric acid 0.01-8.0 and salicylic acid or/and its esters 0.001-6.0, aspirin 0.001-5.0, Arginine Acetylsalicylate Arbitrary or a combination thereof in 0.002-3.0, lysine acetylsalicylate 0.002-4.0, calcium acetylsalicylate urea 0.002-4.0；High The hyaluronic acid of molecular weight or/and hyaluronate 0.1-5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1- 8.0th, the hyaluronic acid of low-molecular-weight or/and hyaluronate 0.1-10.0, the polyglutamic acid of high molecular or/and polyglutamic acid Salt 0.1-4.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-6.0, the polyglutamic acid of low-molecular-weight or/and poly- Glutamate, Glu 0.1-12.0, glutamic acid or/and glutamate, Glu 0.01-10.0, collagen peptide 0.01-8.0, L-Glutamine 0.01-6.0, nicotinic acid 0.01-5.0, nicotiamide 0.01-8.0, chondroitin sulfate 0.01-5.0, heparin sodium 0.01-5.0, trehalose 0.01-9.0, xylitol 0.01-6.0, shitosan 0.01-8.0, sodium alginate 0.01-9.0, xanthan gum 0.01-9.0, poly- second two Alcohol 0.0001-15.0 and solvent：Surplus；
Described nursing agent 2 comprises following mass fraction（Part）Raw material：L-Glutamine 0.01-8.0, high molecular saturating Bright matter acid or/and hyaluronate 0.1-5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1-8.0, low molecule Amount hyaluronic acid or/and hyaluronate 0.1-10.0, the polyglutamic acid of high molecular or/and polyglutamate 0.1-4.0, The polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-6.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1-12.0, glutamic acid or/and glutamate, Glu 0.01-10.0, collagen peptide 0.01-8.0, Vc 0.01-5.0, Ve 0.01- 5.0、Vb50.01-8.0, nicotinic acid 0.01-5.0, nicotiamide 0.01-5.0, nadide 0.01-2.0, coenzyme II 0.01-2.0, Chondroitin sulfate 0.01-5.0, taurine 0.01-5.0, heparin sodium 0.01-5.0, ubiquinone100.01-2.0, trehalose 0.01- 9.0th, sorbic acid or/and its esters 0.001-4.0, glycyrrhizic acid or/and its esters 0.001-4.0, allantoin 0.01-15.0, Herba Marsileae Quadrifoliae Fruit acid 0.01-8.0, citric acid 0.01-5.0 and salicylic acid or/and its esters 0.001-35.0, aspirin 0.001- 25.0th, sodium alginate 0.01-9.0, xanthan gum 0.01-9.0, Polyethylene Glycol 0.0001-15.0 and solvent：Surplus.
2. laser beautifying art nursing agent according to claim 1 it is characterised in that：This laser beautifying art nursing agent be by Nursing agent 1 and No. 2 compositions of nursing agent, wherein, described nursing agent 1 is by following mass percent（%）Raw material composition： Sorbic acid or/and its esters 0.01-2.0, enoxolone 0.01-2.0, glycyrrhizic acid or/and its esters 0.01-2.0, taurine 0.05-4.0, allantoin 0.05-2.0, lactic acid 0.05-4.0, lactate 0.05-4.0, citric acid 0.05-3.0, malic acid 0.05-6.0, tartaric acid 0.05-6.0 and salicylic acid or/and its esters 0.01-4.0, aspirin 0.01-3.0, arginine Arbitrary in aspirin 0.02-2.0, lysine acetylsalicylate 0.02-3.0, calcium acetylsalicylate urea 0.02-3.0 or its Combination；The hyaluronic acid of high molecular or/and hyaluronate 0.1-3.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronic acid Salt 0.1-6.0, the hyaluronic acid of low-molecular-weight or/and hyaluronate 0.1-8.0, the polyglutamic acid of high molecular or/and poly- The polyglutamic acid of glutamate, Glu 0.1-3.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-5.0, low-molecular-weight Or/and polyglutamate 0.1-10.0, glutamic acid or/and glutamate, Glu 0.02-8.0, collagen peptide 0.05-6.0, glutamy Amine 0.05-5.0, nicotinic acid 0.1-3.0, nicotiamide 0.05-5.0, chondroitin sulfate 0.05-3.0, heparin sodium 0.05-3.0, Sargassum Sugared 0.05-7.0, xylitol 0.1-4.0, shitosan 0.1-5.0, sodium alginate 0.1-6.0, xanthan gum 0.1-6.0, Polyethylene Glycol 0.001-12.0 and solvent：Surplus；
Described nursing agent 2 comprises following mass fraction（Part）Raw material：L-Glutamine 0.05-5.0, high molecular saturating Bright matter acid or/and hyaluronate 0.1-3.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1-6.0, low molecule Amount hyaluronic acid or/and hyaluronate 0.1-8.0, the polyglutamic acid of high molecular or/and polyglutamate 0.1-3.0, The polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-5.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1-10.0, glutamic acid or/and glutamate, Glu 0.02-8.0, collagen peptide 0.05-6.0, Vc 0.05-3.0, Ve 0.02- 3.0、Vb50.05-6.0, nicotinic acid 0.1-3.0, nicotiamide 0.05-5.0, nadide 0.01-1.0, coenzyme II 0.01-1.0, sulfur Aching and limp ossein 0.05-3.0, heparin sodium 0.05-3.0, ubiquinone100.01-1.0, trehalose 0.05-7.0, sorbic acid or/and its Salt 0.01-2.0, glycyrrhizic acid or/and its esters 0.01-2.0, allantoin 0.05-2.0, malic acid 0.05-6.0, citric acid 0.05-3.0 and salicylic acid or/and its esters 0.01-4.0, aspirin 0.01-3.0, sodium alginate 0.1-6.0, xanthan gum 0.1-6.0, Polyethylene Glycol 0.001-12.0 and solvent：Surplus.
3. laser beautifying art nursing agent according to claim 1 it is characterised in that：In described laser beautifying art nursing agent The hyaluronic acid of high, normal, basic three kinds of different molecular weight sizes or/and hyaluronate refer to polymer hyaluronic acid or hyalomitome The molecular weight of hydrochlorate is more than 1,800,000 dalton, the molecular weight of middle molecular weight hyaluronic acid or hyaluronate between 1,000, Between 000-1 800 000 dalton, the molecular weight of low molecular weight hyaluronic acid or hyaluronate is less than 600,000 dalton.
4. laser beautifying art nursing agent according to claim 1 it is characterised in that：Described high, normal, basic three kinds of different molecular weights The polyglutamic acid of size or/and polyglutamate refer to that polyphosphazene polymer glutamic acid or the molecular weight of polyglutamate are more than 1,000, 000 dalton, the molecular weight of middle molecule polyglutamic acid or polyglutamate between 600,000-1,000,000 dalton, The molecular weight of low molecular weight polycaprolactone glutamic acid or polyglutamate is less than 100,000 dalton.
5. the laser beautifying art nursing agent according to claim 1 and 2 it is characterised in that：Described Polyethylene Glycol refers to eat Molecular weight more than grade or pharmaceutical grade is any one or a combination thereof in 400-20000 dalton.
6. Energy and comfort according to claim 1 laser beautifying art nursing agent dosage form it is characterised in that：Described convenience is relaxed Suitable laser beautifying art nursing agent dosage form system includes liquid formulation and solid formulation, preferably half fluidised form preparation, more preferably water Property gel, in practical application, can as needed and use Energy and comfort, with described laser beautifying art nursing agent In composition in addition to the solvents be base material, then mix the acceptable safety barrier of laser beautifying art nursing agent or the adjuvant of the present invention, Make the convenient water preparation being suitable for, medicated wine, tincture, suspension, emulsion, cream, unguentum, gel, coagulate using corresponding preparations technology Glue, oil preparation, membrane, spray or patch.
7. a kind of preparation method of the laser beautifying art nursing agent according to claim 1 and 2 is it is characterised in that comprise following Step：
（1）Formula as described in this patent and formula ratio weigh each component of nursing agent 1 respectively, standby；
（2）Formula as described in this patent and formula ratio weigh each component of nursing agent 2 respectively, standby；
（3）Add the solvent of part formulation amount, room temperature or low temperature to mix in each component of nursing agent 1, treat completely After dissolving, add balance solvent, continuing to stir can be prepared by nursing agent 1；
（4）Add the solvent of part formulation amount, room temperature or low temperature to mix in each component of nursing agent 2, treat completely After dissolving, add balance solvent, continuing to stir can be prepared by nursing agent 2.
8. laser beautifying art nursing agent according to claim 7 preparation method it is characterised in that：Described step（3）（4） In room temperature or cryogenic conditions be preferably less than 46 DEG C, again more preferably less than 30 DEG C but be more than 15 DEG C.
9. laser beautifying art nursing agent according to claim 7 preparation method it is characterised in that：Described step（3）（4） In stirring and evenly mixing operating condition be preferably in medical stainless steel blender two-dimensional mixing stirring, more preferably anti-in glass The three-dimensional hybrid in device or 316L stainless steel blender is answered to stir, further preferably real for emulsifying mode under vacuum Existing.
CN201611027888.3A 2016-11-22 2016-11-22 Laser cosmetology nursing agent, preparation and use method thereof Pending CN106420399A (en)

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CN110755679A (en) * 2019-11-15 2020-02-07 杭州欣创医疗器械有限公司 Liquid dressing for laser operation and preparation method thereof
CN114917409A (en) * 2022-06-02 2022-08-19 瑞玞生物医学(深圳)有限公司 Composition based on hyaluronic acid

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CN105748315A (en) * 2016-04-07 2016-07-13 天津嘉氏堂医美科技有限公司 Composition for repairing skin barriers
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CN104840385A (en) * 2015-04-11 2015-08-19 广东医学院 A group of coenzyme Q10 skin protection creams with effects of skin moisturizing, wrinkle preventing and aging resistance
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Application publication date: 20170222