CN106362141A - Safe and multi-effect freckle removing agent and preparation method thereof - Google Patents

Safe and multi-effect freckle removing agent and preparation method thereof Download PDF

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Publication number
CN106362141A
CN106362141A CN201611023586.9A CN201611023586A CN106362141A CN 106362141 A CN106362141 A CN 106362141A CN 201611023586 A CN201611023586 A CN 201611023586A CN 106362141 A CN106362141 A CN 106362141A
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CN
China
Prior art keywords
acid
freckle
solvent
molecular
polyglutamate
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Pending
Application number
CN201611023586.9A
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Chinese (zh)
Inventor
赵永亮
王卫国
王冠轶
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Zhengzhou Bio Engineering Co Ltd
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Zhengzhou Bio Engineering Co Ltd
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Priority to CN201611023586.9A priority Critical patent/CN106362141A/en
Publication of CN106362141A publication Critical patent/CN106362141A/en
Pending legal-status Critical Current

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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    • A61K31/12—Ketones
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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Abstract

The invention discloses a safe and multi-effect freckle removing agent and a preparation method thereof. The freckle removing agent is prepared from a skin care composition, a freckle removing composition and a solvent, wherein various nutrition elements such as collagen and vitamin required by normal skin nutrition are contained; health care ingredients such as coenzyme I, coenzyme II, nicotinamide and coenzyme Q10 required by skin health maintenance are also contained; various ingredients are effectively combined; the mild freckle removing effect can be achieved; the advantages of high safety, use convenience, wide application range, good effect and the like are achieved. The freckle removing agent provided by the invention has the freckle removing and freckle lightening effects, also achieves the effects of freckle formation and regeneration, and also achieves the skin beautification and skin care effects at the same time. The freckle removing agent has no toxicity, no irritation and no allergy, and is almost suitable for all people groups. The preparation process of the freckle removing agent has the advantages that the flow process is simple, convenient and fast; the condition is mild; the temperature rise is not needed; the energy consumption is low; no environment pollution exists; the safe and multi-effect freckle removing agent belongs to a green manufacturing technology worthy of being popularized.

Description

A kind of safe multiple-effect anti-freckle agent and preparation method thereof
Technical field
The invention belongs to cosmetics and technical field of medicine, relate in particular to a kind of safe multiple-effect anti-freckle agent and its Preparation method.
Background technology
Everybody has a love of beauty, and fashion health is even more everyone yearning.The health of skin is ceased with the health breath of whole body Related.Modern scientific research shows, skin is and our the maximum organs of life-critical area.Skin is to protect our bodies First barrier of body health, is to show beautiful main carriers to people again.However, with the quickening of people's rhythm of life, work Make the increasing of pressure, and aggravation the problems such as environmental pollution and reason, the skin health of people such as self health status are not good enough Problem gets more and more.The colour of skin is abnormal, the mottle such as dyschromicum dermatosis patient such as freckle, black speck, chloasma and senile plaque is got over Come more universal.In order to reduce or reducing the incidence rate of these dyskinetic dermatosis patients, people are in life sciences, medical science, pharmacy The research carrying out extensively and profoundly always with fields such as medical cosmetologies, the product of research and development listing or technical method are also multiple Various.Currently for the method for removing of mottle, conventional operative therapy and pharmacotherapy.In operative therapy, method is dispelled with laser For common.Although laser therapy have freckle effect substantially, the effect got instant result, its easy skin ambustion and stay permanent Cicatrix, typically needs laser surgery 4-6 time, every minor tick 3 months, and must be by skilled veteran medical practitioner special The diagnosis and treatment mechanism of industry completing, not only costly in addition it is also necessary to note postoperative long-term maintenance and sun-proof, in addition, it also have a lot Contraindication and uncomfortable crowd, and nonowner can adopt laser speckle dispelling art at any time.Pharmacotherapy can by route of administration It is divided into 2 big class: interior use and external.Innerlich anwenden is divided into oral solid preparations and liquid formulation again, in addition, also injection is as in a large number Vitamin c intravenous drip etc..Chinese medicine and Western medicine can be divided into by drug type again.Due to innerlich anwenden from oral cavity to internal organs Absorption And Metabolism Reach skin focus again, a very long process will be experienced, the effective dose reaching target position is substantially reduced with drug effect, so effect It is difficult to ideal.Medicine for external use also can be divided into Western medicine and Chinese medicine, commonly uses 3% Hydrochinone Cream or 5% ammoniated mercury ointment, and Chinese medicine is then mostly to be Or medicated wine coating affected part is made using virose kinds of traditional Chinese medicines material, or making water decoction fumigation and wash method affected part.These process sides Formula, though there being certain effect, or zest is too strong, or larger containing toxic component or toxic and side effects, when using, greatly All alerting liquid medicine point must not be coated onto on normal skin in order to avoid injured skin, if oral medicine, also remind patient simultaneously, Intermittent use.Therefore, how to provide one kind not only safe but also easy to use and effect significant speckle dispelling method or preparation one for people It is directly one of major issue that skin protection scientific domain is badly in need of solution.
Content of the invention
For solving the deficiency of above-mentioned technical method or product, the invention provides a kind of safe multiple-effect anti-freckle agent and its preparation Method.
The basic ideas of the present invention are first on the premise of ensureing materials safety and skin safe, by common multiple Mottle Producing reason and the parsing of mottle organizational structure, both need to protect based on patient skin, with greater need for speckle dispelling, speckle dispelling and guarantor Protect or repair the theory laid equal stress on, screening has nutrition and health care and acts on and belong to biogenic or biochemical class, food source to skin Property, component based on the component of clear efficacy, with generally acknowledge, there is the vc of broad-spectrum high efficacy safety, ve, vb5, nicotinic acid, nicotinoyl Amine, l- AA2G, sorbic acid and its esters, glycyrrhizic acid and its esters, allantoin, lactic acid, lactate, Fructus Mali pumilae Acid, tartaric acid, citric acid and salicylic acid and its esters etc. as main speckle dispelling composition, according to skin histology with cell to not jljl Matter absorbs or the understanding through rule characteristic and analysis, in the case of without tradition tool toxic and side effects or dripping of irritant drugs, will There is to skin the biogenic of nutrition and health care effect or biochemical class component carries out science and assemble one group of optimization both can protecting The compositionss of the safe multiple-effect of skin nutrition and energy dispelling stain, then be made into conveniently using a kind of gentle technology method Comfortable anti-freckle agent dosage form.
It is an object of the invention to provide a kind of safe multiple-effect anti-freckle agent and preparation method thereof.The anti-freckle agent of the present invention is existing Significantly spot-removal function, and the nutritious effect with protection skin.This anti-freckle agent is by skin care compositionss, spot-eliminating composition Constitute with solvent.This anti-freckle agent contains hyaluronic acid or/and hyaluronate, the senior middle school of high, normal, basic three kinds of different molecular weight sizes The polyglutamic acid of low three kinds of different molecular weight sizes or/and polyglutamate, glutamic acid or/and glutamate, Glu, collagen protein, glue Former protein peptide, vc, ve, vb5, nicotinic acid, nicotiamide, coenzyme i, coenzyme ii, chondroitin sulfate, taurine, heparin sodium, l- Vitamin C Sour 2- glucoside, ubiquinone10, trehalose, sodium alginate, xanthan gum, sorbic acid and its esters, glycyrrhizic acid and its esters, salicylic acid And its esters or esters, aspirin, smart ammonia aspirin, lysine acetylsalicylate, calcium acetylsalicylate urea, allantois Element, lactic acid, lactate, malic acid, tartaric acid, citric acid, Polyethylene Glycol, wine, Oleum Vitis viniferae, glycerol, ethanol, water.This Invention anti-freckle agent is easy to use comfortable, effect is significant, and the easy simultaneously environmental sound of fabricating technology method.
The present invention is achieved in that
The present invention provides a kind of safe multiple-effect anti-freckle agent.The anti-freckle agent of the present invention is by skin care compositionss, spot-eliminating composition With solvent constitute, wherein, described skin care compositionss include high, normal, basic three kinds of different molecular weight sizes hyaluronic acid or/ With hyaluronate, the polyglutamic acid of high, normal, basic three kinds of different molecular weight sizes or/and polyglutamate, glutamic acid or/and paddy Propylhomoserin salt, collagen protein, collagen peptide, vc, ve, vb5, nicotinic acid, nicotiamide, coenzyme i, coenzyme ii, chondroitin sulfate, cattle sulphur Acid, heparin sodium, l- AA2G, ubiquinone10, trehalose, sodium alginate, xanthan gum；Described spot-eliminating composition bag Include vc, ve, vb5, nicotinic acid, nicotiamide, l- AA2G, sorbic acid and its esters, glycyrrhizic acid and its esters, allantois Element, lactic acid, lactate, malic acid, tartaric acid, citric acid and salicylic acid and its esters or esters, aspirin, arginine second Arbitrary or a combination thereof in acyl salicylic acid, lysine acetylsalicylate, calcium acetylsalicylate urea；Described solvent contain wine, Polyethylene Glycol, lactic acid, Oleum Vitis viniferae, glycerol, second alcohol and water；In the situation without tradition tool toxic and side effects or dripping of irritant drugs Under, above-mentioned skin care compositionss, spot-eliminating composition and solvent are carried out science and assembles and optimize, then using certain technique skill Art method is made into the anti-freckle agent dosage form of Energy and comfort.Anti-freckle agent of the present invention is easy to use comfortable, effect is significant, and prepares work The simple simultaneously environmental sound of skill technical method.
The quality proportioning of skin care compositionss of the present invention, spot-eliminating composition and solvent three is: 0.1～98.00: 0.2 ～99.00: 0.1～99.70；
Wherein, described skin care compositionss are made up of the raw material of following mass percent (%): the hyalomitome of high molecular Acid or/and hyaluronate 0.1-5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1-8.0, low-molecular-weight Hyaluronic acid or/and hyaluronate 0.1-10.0, the polyglutamic acid of high molecular or/and polyglutamate 0.1-4.0, in point The polyglutamic acid of son amount or/and polyglutamate 0.1-6.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1- 12.0th, collagen protein 0.01-10.0, collagen peptide 0.01-8.0, coenzyme i 0.01-2.0, coenzyme ii 0.01-2.0, sulphuric acid Chrondroitin 0.01-5.0, taurine 0.01-5.0, heparin sodium 0.01-5.0, ubiquinone100.01-5.0, trehalose 0.01-9.0, Sodium alginate 0.01-9.0, xanthan gum 0.01-9.0；
Described spot-eliminating composition includes the raw material of following mass fraction (part): vc 0.01-5.0, ve 0.01-5.0, vb5 0.01-8.0, nicotinic acid 0.01-5.0, nicotiamide 0.01-15.0, l- AA2G 0.01-8.0, sorbic acid or/and Its esters 0.001-4.0, glycyrrhizic acid or/and its esters 0.001-4.0, allantoin 0.01-15.0, lactate 0.01-5.0, lemon Lemon acid 0.01-5.0, malic acid 0.01-8.0, tartaric acid 0.01-8.0 and salicylic acid or/and its esters or esters 0.001- 35.0th, aspirin 0.001-25.0, Arginine Acetylsalicylate 0.002-30.0, lysine acetylsalicylate 0.002- 40.0th, arbitrary or a combination thereof in calcium acetylsalicylate urea 0.002-40.0；
Solvent of the present invention is made up of the raw material of following mass percent (%): wine 0.0001-40.0, Polyethylene Glycol 0.0001-15.0, lactic acid 0.01-5.0, Oleum Vitis viniferae 0.01-8.0, glycerol 0.0001-10.0, ethanol 0.0001-50.0 and water 0.01-99.9.
As a kind of optimal way of this anti-freckle agent, skin care compositionss in described anti-freckle agent, spot-eliminating composition and molten The quality proportioning of agent three is: 0.2～98.00: 0.3～99.00: 0.1～99.50；Wherein, described skin care compositionss Raw material composition by following mass percent (%): the hyaluronic acid of high molecular or/and hyaluronate 0.1-3.0, middle molecule Amount hyaluronic acid or/and hyaluronate 0.1-6.0, the hyaluronic acid of low-molecular-weight or/and hyaluronate 0.1-8.0, The polyglutamic acid of high molecular or/and polyglutamate 0.1-3.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-5.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1-6.0, collagen protein 0.1-8.0, collagen peptide 0.1-6.0, coenzyme i 0.05-1.0, coenzyme ii 0.05-1.0, chondroitin sulfate 0.1-3.0, taurine 0.1-2.0, heparin sodium 0.1-2.0, ubiquinone100.1-3.0, trehalose 0.1-5.0, sodium alginate 0.1-6.0, xanthan gum 0.1-5.0；
Described spot-eliminating composition includes the raw material of following mass fraction (part): vc 0.1-4.0, ve 0.1-4.0, vb50.1- 6.0th, nicotinic acid 0.05-3.0, nicotiamide 0.05-3.0, l- AA2G 0.1-5.0, sorbic acid or/and its salt 0. 01-2.0, glycyrrhizic acid or/and its esters 0.01-3.0, carbamide 0.1-10.0, allantoin 0.1-8.0, lactate 0.1-3.0, lemon Lemon acid 0.1-3.0, malic acid 0.1-5.0, tartaric acid 0.1-5.0 and salicylic acid or/and its esters or esters 0.01-20.0, second Acyl salicylic acid 0.01-19.0, Arginine Acetylsalicylate 0.02-25.0, lysine acetylsalicylate 0.02-30.0, Ah Si Arbitrary or a combination thereof in woods calcium urea 0.02-30.0；
Described solvent is made up of the raw material of following mass percent (%): wine 0.01-25.0, Polyethylene Glycol 0.01- 10.0th, lactic acid 0.1-3.0, Oleum Vitis viniferae 0.1-4.0, glycerol 0.01-5.0, ethanol 0.01-30.0 and water 0.1-98.5.
Except minority belongs to biological endogenous property or the derivative beyond the region of objective existence of biochemical class component in the anti-freckle agent component of the present invention, other is Biological endogenous property, food-borne, clear efficacy component, wherein, some still constitute substantially becoming of skin histology and cell Point, and, most components have multiple physiology/pharmacological functions or effect.As hyaluronic acid, polyglutamic acid, collagen protein, Collagen peptide, coenzyme i, coenzyme ii, chondroitin sulfate, taurine, heparin, lactic acid, lactate, ubiquinone10It is composition with water The basis of skin histology and cell or maintenance normal skin tissue and cell carry out biogenic physiology work Property composition, meanwhile, they also have defying age and moisturizing, antioxidation and improve the effect such as skin immunity, antiallergic；vc、ve、 vb5, nicotinic acid, nicotiamide, glycyrrhizic acid and its esters, allantoin, lactate, citric acid, malic acid, tartaric acid and salicylic acid and its Salt or esters, aspirin, smart ammonia aspirin, lysine acetylsalicylate, calcium acetylsalicylate urea, then whitening, The aspects such as speckle dispelling, antimicrobial antiphlogistic are respond well, and each component is ingenious more significantly and rapid with the use of its freckle effect；Trehalose With sodium alginate, there is protection Skin Cell and radiation-resistant function under adverse circumstance；Xanthan gum then have good thickening, attachment and Lubrication；Sorbic acid and its esters are well recognized as safe food-level antibacterial preservative, are conducive to keeping the steady in a long-term of product Property and quality.Said components are carried out science assemble and optimize, using solvent of the present invention, using certain Technology Method can prepare the preparation that can eliminate various mottles in the case of no any wound and misery.Said preparation not only can Efficiently dispel or desalinate the size mottle having been formed moreover it is possible to suppression promotes the activity of the tryrosinase of pigment synthesis, so, also The formation of new mottle can be prevented.And there is good Nutritional Nursing Care skin effect.
The hyaluronic acid of high, normal, basic three kinds of different molecular weight sizes in anti-freckle agent of the present invention or/and hyalomitome Hydrochlorate refers to that polymer hyaluronic acid or the molecular weight of hyaluronate are more than 1,800,000 dalton, middle molecular weight hyaluronic acid Or the molecular weight of hyaluronate is between 1,000,000-1,800,000 dalton, low molecular weight hyaluronic acid or hyalomitome The molecular weight of hydrochlorate is less than 600,000 dalton；
The polyglutamic acid of described high, normal, basic three kinds of different molecular weight sizes or/and polyglutamate refer to polyphosphazene polymer glutamic acid or The molecular weight of polyglutamate is more than 1,000,000 dalton, the molecular weight of middle molecule polyglutamic acid or polyglutamate between Between 600,000-1,000,000 dalton, the molecular weight of low molecular weight polycaprolactone glutamic acid or polyglutamate is less than 100,000 dongle ?.
Wine in described solvent includes red wine and white wine；Preferably, it is that extra dry red wine, half extra dry red wine and half are sweet red And extra dry white wine, medium dry white wine and half are sweet white；Polyethylene Glycol in solvent refers to that the molecular weight of more than food stage is 400-20000 dongle Any one in or a combination thereof；Lactic acid in solvent, Oleum Vitis viniferae, glycerol and ethanol are more than food stage；Water is reverse osmosis The above pure water of level or its distilled water thoroughly.
In the anti-freckle agent of the present invention, all components are the product of more than commercially available food stage or medical grade.
The anti-freckle agent dosage form of Energy and comfort of the present invention includes liquid formulation and solid formulation, preferably half fluidised form system Agent, more preferably aqueous gel.In practical application, can as needed and use Energy and comfort, dispelled with described In speckle agent, composition in addition to the solvents is base material, then mixes anti-freckle agent acceptable carrier of the present invention or adjuvant, using corresponding Preparation technique makes the convenient various dosage forms being suitable for, and can be water preparation, medicated wine, tincture, suspension, emulsion, cream, unguentum, coagulate Colloid, coagulant liquid, oil preparation, membrane, spray or patch etc..
Present invention also offers the preparation method of above-mentioned anti-freckle agent, comprise the steps:
(1) formula as described in this patent and formula ratio weigh each component of skin care and spot-eliminating composition respectively, standby；
(2) formula as described in this patent and formula ratio weigh each component, room temperature or the low temperature of this anti-freckle agent solvent for use respectively Mix standby after lower stirring and dissolving；
(3) each component of the skin care compositionss of formula ratio is added solvent, room temperature or the low temperature of part formulation amount Mix after dissolving, obtain mixture a；
(4) each component of the spot-eliminating composition of formula ratio is added the solvent of part formulation amount, room temperature or low temperature dissolving After mix, obtain mixture b；
(5) mixture b is slowly added in mixture a, then residual solvent is added thereto, room temperature or low temperature are equal Even, obtain final product described anti-freckle agent.
Room temperature described in step (2) (3) (4) (5) or cryogenic conditions are preferably less than 45 DEG C, again more preferably less than 25 DEG C But it is more than 12 DEG C.
Mix operating condition after stirring and dissolving described in step (2) (3) (4) (5) to be preferably in medical stainless steel mixing Two-dimensional mixing stirring in device, the three-dimensional hybrid stirring more preferably in glass reactor or 316l stainless steel blender, then The emulsifying mode being preferably under vacuum is realized.
In practical operation, can as needed and use Energy and comfort, with above-mentioned anti-freckle agent as base material, then join Upper anti-freckle agent acceptable carrier of the present invention or adjuvant, make the convenient various dosage forms being suitable for using corresponding preparations technology.
The present invention, compared with traditional speckle dispelling method or technique, has a characteristic that
(1) parsing according to common multiple mottle Producing reason and mottle organizational structure, based on mottle skin protection again of should dispelling Theory carry out comprehensive prescription design；
(2) on anti-freckle agent raw material components select, based on the consideration of safety first principle, skin care raw material used by the present invention Be biological endogenous property, biochemical class, food-borne, clear efficacy component, wherein, some still constitute skin histology and The basis of cell, and, most components have multiple physiology/pharmacological functions and have good protection work to skin With.So, both provide enough nutrition for skin tissue cell, have the function of multiple protective skin again；
(3) it is based on and speckle dispelling should also want skin friendly or toxic and side effects or irritating principle are not produced to body or skin, On speckle dispelling raw material components select, existing suppression tyrosinase activity composition, there are dispelling stain and aging cutin composition again, also disappear Malicious anti-corrosive antibacterial antipathogenic composition, the efficient combination of three not only can efficient speckle dispelling, also can prevent the formation of new speckle；Especially with skin The using cooperatively of skin care compositions, the effect of gentle speckle dispelling and skin nutrition is more notable；
(4) solvent of the present invention is unique, is multiple by wine, Polyethylene Glycol, lactic acid, Oleum Vitis viniferae, glycerol, second alcohol and water etc. Component is constituted, and both can dissolve water-soluble component, also can dissolve alcohol-soluble or oil-soluble or fat-soluble ingredient, and such solvent is constituted Can ensure that raw materials used there is good dissolubility wherein；
(5) the preparation method mild condition of anti-freckle agent of the present invention, process is simple, non-environmental-pollution.Because the present invention is raw materials used It mostly is biochemical class component, more sensitive to physical and chemical factors such as high temperature and illumination, so, by component preferably and process optimization, build Found a kind of process is simple, non-environmental-pollution technical method that can prepare anti-freckle agent of the present invention under room temperature or low temperature；
(6) by the optimum organization of formula and gentle process of preparing using not only successfully solving in this patent prescription Labile active ingredient such as vc etc. easily decomposes, oxidizable, allochroic problem, also solves various active composition and mixes The various stability problems being likely to occur, as stable, thermally-stabilised in light etc., and allow each component produce collaborative or potentiation.
Long-term result of practical application shows in a large number, the invention has the following beneficial effects:
(1) speckle dispelling is gentle, hurtless measure no pain.In the formula of this anti-freckle agent, containing multiple foster skin skin care ingredient such as hyaluronic acids, Collagen protein, vitamin etc. are it is ensured that skin friendly while speckle dispelling；
(2) easy to use, excellent effect.Only smear mottle 1-3 time daily with this anti-freckle agent, 2 weeks take effect, be within 4 weeks a course for the treatment of, The 3-5 course for the treatment of can thoroughly eliminate or desalinate mottle, and does not stay cicatrix, goes back user fitness skin；
(3) safe, widely applicable.Anti-freckle agent of the present invention is nontoxic, non-stimulated, no allergy is it is adaptable to nearly all crowd；
(4) the preparation method mild condition of anti-freckle agent of the present invention, need not heat up, energy consumption low, technological process is short, and no environment is dirty Dye, is a kind of green manufacture technology being worthy to be popularized.
The trial effect of 120 people volunteers is as follows:
(1) case selection: randomly choosing has the Pigmented patient such as different degrees of chloasma, butterfly spot, senile plaque 120 Example, wherein, male 50, women 70, age 20-65 year, 40 years old mean age, course of disease 2-300 month, average 15 months. Mottle is located at face person 98, face, the equal originator in the back of the hand face 22.Selected mottle size all has from needle point to Semen Pisi sativi size person, Always calm area is the 0.1～10% of facial area.Experimenter carries out routine examination before trying out, and in addition to mottle, other physical abilitys are showed no Abnormal.
(2) diagnostic criteria: judge with reference to nineteen ninety-five " People's Republic of China's traditional Chinese medicine industry standard ".
(3) Therapeutic Method: after clean skin, use daily anti-freckle agent spot printing mottle 2-3 time, at least sooner or later each 1 time, if middle use water Wash off and need to add 1 time to ensure there is anti-freckle agent all the time on mottle, 1-3 minute can be massaged after smearing for the first time to promote to absorb, Then spot printing, once to increase dose, takes effect in 1-2 week again, and 4 weeks is a course for the treatment of, and according to circumstances, mottle bigot can continuously make With the 3-5 course for the treatment of.
(4) criterion of therapeutical effect: substantially subtract light with mottle or disappear that to reach more than 90% person be effective, mottle more than 50% person of disappearing is Effectively, before and after treatment, unchanged person is invalid.
(5) result: in 120, effective 88, effective 30, invalid 2, obvious effective rate 73.3%, effective percentage 25.0%, no Efficiency 1.7%, total effective rate 98.3%.
Specific embodiment
With reference to embodiment, the present invention is described in detail:
Embodiment l:
Formula: in described anti-freckle agent, the quality proportioning of skin care compositionss, spot-eliminating composition and solvent three is: 0.10: 0.20∶99.70；
Wherein, described skin care compositionss are made up of the raw material of following mass percent (%): the hyalomitome of high molecular Acid or/and the hyaluronic acid of hyaluronate 0.1, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 8.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 0.1, high molecular or/and polyglutamate 0.1, the polyglutamic acid of middle-molecular-weihydroxyethyl or/ With polyglutamate 6.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1, collagen protein 0.01, collagen peptide 8.0th, coenzyme i 2.0, coenzyme ii 0.01, chondroitin sulfate 0.01, taurine 0.01, heparin sodium 5.0, ubiquinone100.01st, sea Algae sugar 0.01, sodium alginate 0.01；Xanthan gum 9.0；
Described spot-eliminating composition includes the raw material of following mass fraction (part): vc 0.01, ve 0.01, vb50.01st, nicotinic acid 0.01st, nicotiamide 15.0, l- AA2G 0.01, sorbic acid or/and its salt 0.001, glycyrrhizic acid or/and its esters 4.0th, allantoin 0.01, lactate 5.0, citric acid 0.01, malic acid 0.01, tartaric acid 0.01 and salicylic acid or/and its esters Or esters 0.001, aspirin 25.0, Arginine Acetylsalicylate 0.002, lysine acetylsalicylate 0.002, Ah Si Woods calcium urea 40.0；
Described solvent is made up of the raw material of following mass percent (%): wine 0.0001, Macrogol 1000 0.0001, Lactic acid 5.0, Oleum Vitis viniferae 0.01, glycerol 0.0001, ethanol 5.0 and water 90.0；
Preparation method: comprise the steps of
(1) formula as described in this patent and formula ratio weigh each component of skin care and spot-eliminating composition respectively, standby；
(2) formula as described in this patent and formula ratio weigh each component, room temperature or the low temperature of this anti-freckle agent solvent for use respectively Mix standby after lower stirring and dissolving；
(3) each component of the skin care compositionss of formula ratio is added solvent, room temperature or the low temperature of part formulation amount Mix after dissolving, obtain mixture a；
(4) each component of the spot-eliminating composition of formula ratio is added the solvent of part formulation amount, room temperature or low temperature dissolving After mix, obtain mixture b；
(5) mixture b is slowly added in mixture a, then residual solvent is added thereto, room temperature or low temperature are equal Even, obtain final product described anti-freckle agent.
Embodiment 2:
Formula: in described anti-freckle agent, the quality proportioning of skin care compositionss, spot-eliminating composition and solvent three is: 8.00: 9.00∶83.00；
Wherein, described skin care compositionss are made up of the raw material of following mass percent (%): the hyalomitome of high molecular Acid or/and the hyaluronic acid of hyaluronate 5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 10.0, high molecular or/and the polyglutamic acid of polyglutamate 4.0, middle-molecular-weihydroxyethyl Or/and the polyglutamic acid of polyglutamate 0.1, low-molecular-weight or/and polyglutamate 12.0, collagen protein 10.0, collagen egg White peptide 0.01, coenzyme i 0.01, coenzyme ii 2.0, chondroitin sulfate 5.0, taurine 5.0, heparin sodium 0.01, ubiquinone105.0、 Trehalose 9.0, sodium alginate 9.0；Xanthan gum 0.01；
Described spot-eliminating composition includes the raw material of following mass fraction (part): vc 5.0, ve 5.0, vb58.0th, nicotinic acid 5.0, Nicotiamide 0.01, l- AA2G 8.0, sorbic acid or/and its salt 4.0, glycyrrhizic acid or/and its esters 0.001, urine Bursin 15.0, lactate 0.01, citric acid 5.0, malic acid 8.0, tartaric acid 8.0 and salicylic acid or/and its esters or esters 35.0th, aspirin 0.001, Arginine Acetylsalicylate 30.0, lysine acetylsalicylate 40.0；
Described solvent is made up of the raw material of following mass percent (%): wine 40.0, Macrogol 2000 15.0, lactic acid 0.01st, Oleum Vitis viniferae 8.0, glycerol 0.0001, ethanol 10.0 and water 27.0；
Preparation method: with embodiment 1.
Embodiment 3:
Formula: in described anti-freckle agent, the quality proportioning of skin care compositionss, spot-eliminating composition and solvent three is: 15.00: 15.00∶70.00；
Wherein, described skin care compositionss are made up of the raw material of following mass percent (%): the hyalomitome of high molecular Acid or/and the hyaluronic acid of hyaluronate 1.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 1.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 1.0, high molecular or/and polyglutamate 2.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/ With polyglutamate 2.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 2.0, collagen protein 5.0, collagen peptide 4.0th, coenzyme i 1.0, coenzyme ii 1.0, chondroitin sulfate 2.0, taurine 3.0, heparin sodium 2.0, ubiquinone103.0th, trehalose 5.0th, sodium alginate 5.0, xanthan gum 4.0；
Described spot-eliminating composition includes the raw material of following mass fraction (part): vc 3.0, ve 2.50, vb54.0th, nicotinic acid 2.0th, nicotiamide 3.0, l- AA2G 4.0, sorbic acid or/and its salt 2.0, glycyrrhizic acid or/and its esters 0.1, Allantoin 7.0, lactate 3.0, citric acid 3.0, malic acid 4.0, tartaric acid 4.0 and salicylic acid or/and its esters or esters 18.0th, aspirin 12.50, Arginine Acetylsalicylate 15.0；
Described solvent is made up of the raw material of following mass percent (%): wine 20.0, PEG400 8.0, lactic acid 3.0th, Oleum Vitis viniferae 4.0, glycerol 10.0, ethanol 5.0 and water 55.0；
Preparation method: with embodiment 1.
Embodiment 4:
Formula: in described anti-freckle agent, the quality proportioning of skin care compositionss, spot-eliminating composition and solvent three is: 98.00: 1.90∶0.10；
Wherein, described skin care compositionss are made up of the raw material of following mass percent (%): the hyalomitome of high molecular Acid or/and the hyaluronic acid of hyaluronate 2.50, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 4.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 5.0, high molecular or/and polyglutamate 2.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/ With polyglutamate 3.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 6.0, collagen protein 2.0, collagen peptide 1.0th, coenzyme i 0.1, coenzyme ii 0.2, chondroitin sulfate 2.50, taurine 1.0, heparin sodium 0.5, ubiquinone100.2nd, trehalose 3.0th, sodium alginate 2.0, xanthan gum 2.0；
Described spot-eliminating composition includes the raw material of following mass fraction (part): vc 1.0, ve 4.0, vb51.0th, nicotinic acid 0.5, Nicotiamide 1.0, sorbic acid or/and its salt 1.0, l- AA2G 0.1, glycyrrhizic acid or/and its esters 0.5, allantois Element 1.0, lactate 0.1, citric acid 1.0, malic acid 1.0, tartaric acid 1.0 and salicylic acid or/and its esters or esters 10.0, second Acyl salicylic acid 0.50；
Described solvent is made up of the raw material of following mass percent (%): wine 0.1, Macrogol 8000 0.1, lactic acid 0.1st, Oleum Vitis viniferae 0.1, glycerol 0.1, ethanol 0.1 and water 99.40；
Preparation method: with embodiment 1.
Embodiment 5:
Formula: in described anti-freckle agent, the quality proportioning of skin care compositionss, spot-eliminating composition and solvent three is: 3.00: 5.00∶92.00；
Wherein, described skin care compositionss are made up of the raw material of following mass percent (%): the hyalomitome of high molecular Acid or/and the hyaluronic acid of hyaluronate 2.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 3.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 2.0, high molecular or/and polyglutamate 2.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/ With polyglutamate 4.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 3.0, collagen protein 3.0, collagen peptide 3.0th, coenzyme i 0.5, coenzyme ii 0.5, chondroitin sulfate 3.0, taurine 4.0, heparin sodium 1.0, ubiquinone100.5th, trehalose 6.0th, sodium alginate 6.0, xanthan gum 6.0；
Described spot-eliminating composition includes the raw material of following mass fraction (part): vc 2.0, ve 1.0, vb52.0th, nicotinic acid 1.0, Nicotiamide 2.0, l- AA2G 2.0, sorbic acid or/and its salt 0.5, glycyrrhizic acid or/and its esters 1.0, allantois Element 2.0, lactate 2.0, citric acid 2.0, malic acid 2.0, tartaric acid 2.0 and salicylic acid or/and its esters or esters 4.0；
Described solvent is made up of the raw material of following mass percent (%): wine 0.1, PEG 20000 5, lactic acid 5, Oleum Vitis viniferae 0.1, glycerol 3, ethanol 15 and water 71.8；
Preparation method: with embodiment 1.
Embodiment 6:
Formula: in described anti-freckle agent, the quality proportioning of skin care compositionss, spot-eliminating composition and solvent three is: 0.50: 99.00∶0.50；
Wherein, described skin care compositionss are made up of the raw material of following mass percent (%): the hyalomitome of high molecular Acid or/and the hyaluronic acid of hyaluronate 2.50, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 4.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 5.0, high molecular or/and polyglutamate 2.0, the polyglutamic acid of middle-molecular-weihydroxyethyl or/ With polyglutamate 3.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 6.0, collagen protein 5.0, collagen peptide 4.0th, coenzyme i 1.0, coenzyme ii 1.0, chondroitin sulfate 2.5, taurine 2.5, heparin sodium 2.5, ubiquinone102.5th, trehalose 4.5th, sodium alginate 4.5, xanthan gum 4.5；
Described spot-eliminating composition includes the raw material of following mass fraction (part): vc 2.5, ve 2.5, vb54.0th, nicotinic acid 2.5, Nicotiamide 2.5, l- AA2G 4.0, sorbic acid or/and its salt 0.1, glycyrrhizic acid or/and its esters 1.5, allantois Element 4.0, lactate 3.0, citric acid 4.0, malic acid 4.0, tartaric acid 4.0 and salicylic acid or/and its esters 20.0；
Described solvent is made up of the raw material of following mass percent (%): wine 0.01, PEG20000 0.05, breast Acid 0.3, Oleum Vitis viniferae 0.5, glycerol 0.01, ethanol 50.0 and water 49.1；
Preparation method: with embodiment 1.
Embodiment 7:
Formula: in described anti-freckle agent, the quality proportioning of skin care compositionss, spot-eliminating composition and solvent three is: 6.00: 6.00∶88.00；
Wherein, described skin care compositionss are made up of the raw material of following mass percent (%): the hyalomitome of high molecular Acid or/and the hyaluronic acid of hyaluronate 4.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 6.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 8.0, high molecular or/and polyglutamate 0.5, the polyglutamic acid of middle-molecular-weihydroxyethyl or/ With polyglutamate 0.6, the polyglutamic acid of low-molecular-weight or/and polyglutamate 1.2, collagen protein 8.0, collagen peptide 6.0th, coenzyme i 0.8, coenzyme ii 0.6, chondroitin sulfate 4.0, taurine 4.0, heparin sodium 4.0, ubiquinone104.0th, trehalose 8.0th, sodium alginate 8.0, xanthan gum 6.0；
Described spot-eliminating composition includes the raw material of following mass fraction (part): vc 4.0, ve 3.0, vb54.0th, nicotinic acid 2.0, Nicotiamide 4.0, l- AA2G 6.0, sorbic acid or/and its salt 3.0, glycyrrhizic acid or/and its esters 2.5, allantois Element 8.0, lactate 4.0, citric acid 0.5, malic acid 1.5, tartaric acid 1.5 and salicylic acid salt 0.5；
Described solvent is made up of the raw material of following mass percent (%): wine 1.0, polyethylene glycol 6000 1.0, lactic acid 1.0th, Oleum Vitis viniferae 2.0, glycerol 1.0, ethanol 2.0 and water 92.0；
Preparation method: with embodiment 1.
The invention is not restricted to case study on implementation described above.

Claims (10)

1. a kind of safe multiple-effect anti-freckle agent it is characterised in that: this anti-freckle agent is by skin care compositionss, spot-eliminating composition and molten Agent is constituted, and wherein, described skin care compositionss include the hyaluronic acid or/and thoroughly of high, normal, basic three kinds of different molecular weight sizes Bright matter hydrochlorate, the polyglutamic acid of high, normal, basic three kinds of different molecular weight sizes or/and polyglutamate, glutamic acid or/and glutamic acid Salt, collagen protein, collagen peptide, coenzyme i, coenzyme ii, chondroitin sulfate, taurine, heparin sodium, ubiquinone10, trehalose, sea Sodium alginate, xanthan gum；Described spot-eliminating composition includes vc, ve, vb5, nicotinic acid, nicotiamide, l- AA2G, mountain Pears acid or/and salt, glycyrrhizic acid or/and salt, allantoin, lactate, malic acid, tartaric acid, citric acid and salicylic acid and its Salt or esters, aspirin, smart ammonia aspirin, lysine acetylsalicylate, calcium acetylsalicylate urea arbitrary or its Combination；Described solvent contains wine, lactic acid, Polyethylene Glycol, Oleum Vitis viniferae, glycerol, second alcohol and water；
The quality proportioning of described skin care compositionss, spot-eliminating composition and solvent three is: 0.1～98.00: 0.2～99.00 : 0.1～99.70；Wherein, described skin care compositionss are made up of the raw material of following mass percent (%): high molecular Hyaluronic acid or/and hyaluronate 0.1-5.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1-8.0, low The hyaluronic acid of molecular weight or/and hyaluronate 0.1-10.0, the polyglutamic acid of high molecular or/and polyglutamate 0.1- 4.0th, the polyglutamic acid of middle-molecular-weihydroxyethyl or/and polyglutamate 0.1-6.0, the polyglutamic acid of low-molecular-weight or/and polyglutamic acid Salt 0.1-12.0, collagen protein 0.01-10.0, collagen peptide 0.01-8.0, coenzyme i 0.01-2.0, coenzyme ii 0.01- 2.0th, chondroitin sulfate 0.01-5.0, taurine 0.01-5.0, heparin sodium 0.01-5.0, ubiquinone100.01-5.0, trehalose 0.01-9.0, sodium alginate 0.01-9.0, xanthan gum 0.01-9.0；
Described spot-eliminating composition includes the raw material of following mass fraction (part): vc 0.01-5.0, ve 0.01-5.0, vb5 0.01-8.0, nicotinic acid 0.01-5.0, nicotiamide 0.01-15.0, l- AA2G 0.01-8.0, sorbic acid or/and Its esters 0.001-4.0, glycyrrhizic acid or/and its esters 0.001-4.0, allantoin 0.01-15.0, lactate 0.01-5.0, lemon Lemon acid 0.01-5.0, malic acid 0.01-8.0, tartaric acid 0.01-8.0 and salicylic acid or/and its esters or esters 0.001- 35.0th, aspirin 0.001-25.0, Arginine Acetylsalicylate 0.002-30.0, lysine acetylsalicylate 0.002- 40.0th, arbitrary or a combination thereof in calcium acetylsalicylate urea 0.002-40.0；
Solvent of the present invention is made up of the raw material of following mass percent (%): wine 0.0001-40.0, Polyethylene Glycol 0.0001-15.0, lactic acid 0.01-5.0, Oleum Vitis viniferae 0.01-8.0, glycerol 0.0001-10.0, ethanol 0.0001-50.0 and water 0.01-99.9；
Above-mentioned skin care compositionss, spot-eliminating composition and solvent are carried out science assemble and optimize, then using certain technique Technical method is made into the anti-freckle agent dosage form of Energy and comfort.
2. anti-freckle agent according to claim 1 it is characterised in that: this anti-freckle agent be skin care compositionss, speckle dispelling combination Thing and solvent carry out science and assemble and optimize, then are prepared from using certain technology method, described skin care combination The more high quality proportioning of thing, spot-eliminating composition and solvent three is: 0.2～98.00: 0.3～99.00: 0.1～99.50；Its In, described skin care compositionss press the raw material composition of following mass percent (%): the hyaluronic acid of high molecular or/and The hyaluronic acid of hyaluronate 0.1-3.0, the hyaluronic acid of middle-molecular-weihydroxyethyl or/and hyaluronate 0.1-6.0, low-molecular-weight Or/and the polyglutamic acid of hyaluronate 0.1-8.0, high molecular or/and polyglutamate 0.1-3.0, middle-molecular-weihydroxyethyl poly- Glutamic acid or/and polyglutamate 0.1-5.0, the polyglutamic acid of low-molecular-weight or/and polyglutamate 0.1-6.0, collagen egg White 0.1-8.0, collagen peptide 0.1-6.0, coenzyme i 0.05-1.0, coenzyme ii 0.05-1.0, chondroitin sulfate 0.1-3.0, Taurine 0.1-2.0, heparin sodium 0.1-2.0, ubiquinone100.1-3.0, trehalose 0.01-9.0, sodium alginate 0.01-6.0, Huang Virgin rubber 0.1-5.0；
Described spot-eliminating composition includes the raw material of following mass fraction (part): vc 0.1-4.0, ve 0.1-4.0, vb50.1- 6.0th, nicotinic acid 0.05-3.0, nicotiamide 0.05-3.0, l- AA2G 0.1-5.0, sorbic acid or/and its salt 0. 01-2.0, glycyrrhizic acid or/and its esters 0. 01-3.0, allantoin 0. 1-8.0, lactate 0.1-3.0, citric acid 0.1-3.0, Malic acid 0.1-5.0, tartaric acid 0.1-5.0 and salicylic acid or/and its esters or esters 0.01-20.0, aspirin 0.01- 19.0th, Arginine Acetylsalicylate 0.02-25.0, lysine acetylsalicylate 0.02-30.0, calcium acetylsalicylate urea 0.02- Arbitrary or a combination thereof in 30.0；
Described solvent is made up of the raw material of following mass percent (%): wine 0.01-25.0, Polyethylene Glycol 0.01- 10.0th, lactic acid 0.1-3.0, Oleum Vitis viniferae 0.1-4.0, glycerol 0.01-5.0, ethanol 0.01-30.0 and water 0.1-98.5.
3. anti-freckle agent according to claim 1 it is characterised in that: the high, normal, basic three kinds of different moleculars in described anti-freckle agent The hyaluronic acid of amount size or/and hyaluronate refer to that polymer hyaluronic acid or the molecular weight of hyaluronate are more than 1, 800,000 dalton, the molecular weight of middle molecular weight hyaluronic acid or hyaluronate is between 1,000,000-1 800 000 dalton Between, the molecular weight of low molecular weight hyaluronic acid or hyaluronate is less than 600,000 dalton.
4. anti-freckle agent according to claim 1 it is characterised in that: the poly- paddy of described high, normal, basic three kinds of different molecular weight sizes Propylhomoserin or/and polyglutamate refer to that polyphosphazene polymer glutamic acid or the molecular weight of polyglutamate are more than 1,000,000 dalton, The molecular weight of middle molecule polyglutamic acid or polyglutamate between 600,000-1,000,000 dalton, low molecular weight polycaprolactone paddy The molecular weight of propylhomoserin or polyglutamate is less than 100,000 dalton.
5. the anti-freckle agent according to claim 1 and 2 it is characterised in that: the wine in described solvent includes red wine And white wine, the Polyethylene Glycol in solvent refer to more than food stage molecular weight be 400-20000 dalton in any one Or a combination thereof, lactic acid in solvent, Oleum Vitis viniferae, glycerol and ethanol is more than food stage, and water is that more than reverse osmosiss level is pure Water or its distilled water.
6. Energy and comfort according to claim 1 anti-freckle agent dosage form it is characterised in that: the anti-freckle agent of described Energy and comfort Dosage form means water preparation, medicated wine, tincture, suspension, emulsion, cream, unguentum, gel, coagulant liquid, oil preparation, membrane, spray or patch Agent.
7. a kind of preparation method of anti-freckle agent according to claim 1 is it is characterised in that comprise the steps of
(1) formula as described in this patent and formula ratio weigh each component of skin care and spot-eliminating composition respectively, standby；
(2) formula as described in this patent and formula ratio weigh each component, room temperature or the low temperature of this anti-freckle agent solvent for use respectively Mix standby after lower stirring and dissolving；
(3) each component of the skin care compositionss of formula ratio is added solvent, room temperature or the low temperature of part formulation amount Mix after dissolving, obtain mixture a；
(4) each component of the spot-eliminating composition of formula ratio is added the solvent of part formulation amount, room temperature or low temperature dissolving After mix, obtain mixture b；
(5) mixture b is slowly added in mixture a, then residual solvent is added thereto, room temperature or low temperature are equal Even, obtain final product described anti-freckle agent.
8. anti-freckle agent according to claim 7 preparation method it is characterised in that: in described step (2) (3) (4) (5) Room temperature or cryogenic conditions are preferably less than 45 DEG C, again more preferably less than 25 DEG C but be more than 12 DEG C.
9. anti-freckle agent according to claim 7 preparation method it is characterised in that: in described step (2) (3) (4) (5) The two-dimensional mixing stirring that operating condition is preferably in medical stainless steel blender is mixed, more preferably in glass after stirring and dissolving Three-dimensional hybrid stirring in reactor or 316l stainless steel blender, further preferably real for emulsifying mode under vacuum Existing.
10. Energy and comfort according to claim 1 anti-freckle agent dosage form it is characterised in that: the speckle dispelling of described Energy and comfort Agent dosage form includes liquid formulation and solid formulation, preferably half fluidised form preparation, more preferably aqueous gel；In practical application When, can as needed and the Energy and comfort that uses, with described anti-freckle agent, composition in addition to the solvents, as base material, then is mixed Anti-freckle agent acceptable carrier of the present invention or adjuvant, make the convenient water preparation being suitable for, medicated wine, tincture using corresponding preparations technology Agent, suspension, emulsion, cream, unguentum, gel, coagulant liquid, oil preparation, membrane, spray or patch.
CN201611023586.9A 2016-11-22 2016-11-22 Safe and multi-effect freckle removing agent and preparation method thereof Pending CN106362141A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109453078A (en) * 2018-11-19 2019-03-12 重庆凝骄生物科技有限公司 A kind of bionical substrate water gel mask and preparation method thereof
CN112656713A (en) * 2020-12-25 2021-04-16 华熙生物科技股份有限公司 Cosmetic composition containing hyaluronic acid and/or derivatives thereof, and preparation method and application thereof

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CN1761450A (en) * 2003-02-13 2006-04-19 株式会社林原生物化学研究所 Skin preparation for external use characterized by containing sugar derivative of a,a-trehalose
CN1803124A (en) * 2005-01-12 2006-07-19 东海生物科技股份有限公司 Gama-poly glutamic acid, gama-poly glutamic acid salt and use of hydrogel thereof
CN101791283A (en) * 2010-02-05 2010-08-04 张德文 Cosmetic capable of eliminating striae gravidarum and scars
CN105963204A (en) * 2016-06-27 2016-09-28 中国人民解放军总医院 Anti-allergic mask with moisturizing and repairing functions and preparation method of anti-allergic mask

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Publication number Priority date Publication date Assignee Title
CN1761450A (en) * 2003-02-13 2006-04-19 株式会社林原生物化学研究所 Skin preparation for external use characterized by containing sugar derivative of a,a-trehalose
CN1803124A (en) * 2005-01-12 2006-07-19 东海生物科技股份有限公司 Gama-poly glutamic acid, gama-poly glutamic acid salt and use of hydrogel thereof
CN101791283A (en) * 2010-02-05 2010-08-04 张德文 Cosmetic capable of eliminating striae gravidarum and scars
CN105963204A (en) * 2016-06-27 2016-09-28 中国人民解放军总医院 Anti-allergic mask with moisturizing and repairing functions and preparation method of anti-allergic mask

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109453078A (en) * 2018-11-19 2019-03-12 重庆凝骄生物科技有限公司 A kind of bionical substrate water gel mask and preparation method thereof
CN109453078B (en) * 2018-11-19 2021-09-21 中国人民解放军陆军军医大学第一附属医院 Bionic matrix hydrogel mask and preparation method thereof
CN112656713A (en) * 2020-12-25 2021-04-16 华熙生物科技股份有限公司 Cosmetic composition containing hyaluronic acid and/or derivatives thereof, and preparation method and application thereof

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Application publication date: 20170201