CN106074220B - A kind of nano liposomes facial mask and preparation method thereof - Google Patents
A kind of nano liposomes facial mask and preparation method thereof Download PDFInfo
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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Abstract
The invention discloses a kind of nano liposomes facial mask and preparation method thereof, the facial mask is mainly prepared by 500,000 molecular weight sodium hyaluronates, 10,000 molecular weight sodium hyaluronates, xanthans, collagen, trimethylglycine, PEG 40, lecithin, vitamin E, Co-Q10, olive oil, allantoin, rilanit special and polysorbate20.The facial mask Transdermal absorption effect is good, and moistening effect is good, uses no discomfort.And manufacture craft is simple.
Description
Technical field
The present invention relates to a kind of facial masks and preparation method thereof, and in particular to a kind of nano liposomes facial mask and its preparation side
Method.
Background technology：
Skin has large effect to the image, makings and mental health of people, and with the change of living environment, age increases
Long, the skin of people can vary widely, and especially exposed facial skin changes greatly, and the good facial mask of science is selected
Maintaining skin, not only can delay skin aging process significantly, can also effectively mitigate and dispel the color spot generated, acne print and wrinkle
Line etc. makes skin become delicate smooth, high resilience.Facial mask is a kind of cosmetics and skincare product applied on the face, by 20-30 after applying
Minute, will be formed one layer it is tight in film on the face, so referred to as facial mask.It collects cleaning, nursing, three kinds of nutrition skin of face
Function is a kind of very ancient cosmetics in one.Facial mask utilizes the of short duration time applied in face, the sky in the temporarily isolation external world
Gas and dust, improve skin temperature, and the pore expansion of skin promotes sweat gland secretion and metabolism, makes in the oxygen content of skin
It rises, is conducive to the oil substances that skin excludes the product and accumulation of epidermal cell metabolism, the moisture in facial mask penetrates into flesh
The cuticula of skin epidermis, skin become soft, increase elasticity, skin is naturally bright flexible, and improvement has been presented.
As pollution aggravation and people increase the attention of skin care, the usage amount of facial mask is also gradually increased.Because oil is molten
The small-molecule substance of property will produce very greasy discomfort.Therefore commercially available facial mask currently on the market can only add water solubility
Substance, such as sodium hyaluronate, xanthans, the substances such as carbomer.And the cuticula of skin is lipophilic, water-soluble substance is not
It can preferably be absorbed by skin, i.e., water-soluble substances cannot effectively reach long-term moisturizing through keratoderma, will not more produce
Raw apparent repair.
Invention content：
Technical problem to be solved by the present invention lies in a kind of nano liposomes facial masks of offer and preparation method thereof.The face
Film Transdermal absorption effect is good, and moistening effect is good, uses no discomfort.And manufacture craft is simple.
In order to solve the above technical problems, the present invention is realized using following technical scheme：A kind of nano liposomes facial mask, mainly
By 1-2 parts of 500,000 molecular weight sodium hyaluronate, 0.05-1.0 parts of 10,000 molecular weight sodium hyaluronate, 0.05-1.0 parts of xanthans, collagen 5-
15 parts, 1-3 parts of trimethylglycine, 5-15 parts of PEG-40,5-15 parts of lecithin, 1-10 parts of vitamin E, Co-Q10 5-
It is prepared by -20 0.5-1.5 parts of 15 parts, 40-60 parts of olive oil, 5-15 parts of allantoin, 1-10 parts of rilanit special and polysorbate
It forms.
It in nano liposomes facial mask above-mentioned, calculates by weight, mainly very much by 1-2 parts of 500,000 molecular weight sodium hyaluronate, 1
0.2-0.8 parts of sodium hyaluronate of son amount, 0.2-0.8 parts of xanthans, 8-12 parts of collagen, 1.5-2.5 parts of trimethylglycine, PEG-
40 8-12 parts, 8-12 parts of lecithin, 2-8 parts of vitamin E, 8-12 parts of Co-Q10,45-55 parts of olive oil, allantoin 8-12
- 200.8-1.2 parts of part, 2-8 parts of rilanit special and polysorbate are prepared.
It in nano liposomes facial mask above-mentioned, calculates by weight, mainly very much by 1.5 parts of 500,000 molecular weight sodium hyaluronate, 1
0.5 part of sodium hyaluronate of son amount, 0.5 part of xanthans, 10 parts of collagen, 2 parts of trimethylglycine, 10 parts of PEG-40, lecithin 10
Part, 5 parts of vitamin E, 10 parts of Co-Q10,50 parts of olive oil, 10 parts of allantoin, 5 parts of rilanit special and polysorbate-
20 1 parts are prepared.
A kind of preparation method of nano liposomes facial mask, includes the following steps：
（1）Take 500,000 molecular weight sodium hyaluronates, 10,000 molecular weight sodium hyaluronates, xanthans, collagen, trimethylglycine and
Purified water is added in PEG-40, and stirring and dissolving obtains water phase, spare；
（2）Lecithin, vitamin E, Co-Q10, olive oil, allantoin, rilanit special and polysorbate -20 are taken,
It stirs and evenly mixs, heating obtains oil phase until be completely dissolved, spare；
（3）Purified water is added into oil phase, disperses, homogeneous operation obtains nanometer grade liposome, spare；
（4）Nanometer grade liposome is imported in water phase, purified water is added under stirring condition, mixing obtains liposome facial mask liquid, standby
With；
（5）Sterilizing：Liposome facial mask liquid is sterilized quickly through 120-140 DEG C of sterilizing pipeline, obtains sterile liposome
Facial mask, it is spare；
（6）It is filling：Sterile liposome facial mask is filling in facial mask bag, sterile sealing to get.
In the preparation method of nano liposomes facial mask above-mentioned, include the following steps：
（1）Take 500,000 molecular weight sodium hyaluronates, 10,000 molecular weight sodium hyaluronates, xanthans, collagen, trimethylglycine and
450-550 parts by volume purified waters are added in PEG-40, and stirring and dissolving in course of dissolution, controlled at 40-45 DEG C, obtains water phase,
It is spare；
（2）Lecithin, vitamin E, Co-Q10, olive oil, allantoin, rilanit special and polysorbate -20 are taken,
After stirring and evenly mixing, 25-35min is heated at 55-65 DEG C, is completely dissolved, obtains oil phase, it is spare；
（3）At 55-65 DEG C, 80-120 parts by volume purified waters are added into oil phase, after dispersion, in 1000Bar-1500Bar
Under the conditions of, homogeneous operates 2-3 times, obtains nanometer grade liposome, spare；
（4）Nanometer grade liposome is imported in water phase, under stirring condition plus purified water is to 800-1200 parts by volume, mixing,
Liposome facial mask liquid is obtained, it is spare；
（5）Sterilizing：Liposome facial mask liquid is subjected to sterilizing 1-10min quickly through 120-140 DEG C of sterilizing pipeline, is obtained sterile
Liposome facial mask, it is spare；
（6）It is filling：Sterile liposome facial mask is filling in facial mask bag, sterile sealing to get.
In the preparation method of nano liposomes facial mask above-mentioned, include the following steps：
（1）Take 500,000 molecular weight sodium hyaluronates, 10,000 molecular weight sodium hyaluronates, xanthans, collagen, trimethylglycine and
500 parts by volume purified waters are added in PEG-40, and stirring and dissolving in course of dissolution, controlled at 40-45 DEG C, obtains water phase, spare；
（2）Lecithin, vitamin E, Co-Q10, olive oil, allantoin, rilanit special and polysorbate -20 are taken,
After stirring and evenly mixing, 30min is heated at 55-65 DEG C, is completely dissolved, obtains oil phase, it is spare；
（3）At 55-65 DEG C, 100 parts by volume purified waters are added into oil phase, after dispersion, in 1000Bar-1500Bar conditions
Under, homogeneous operates 3 times, obtains nanometer grade liposome, spare；
（4）Nanometer grade liposome is imported in water phase, under stirring condition plus purified water is to 1000 parts by volume, and mixing obtains fat
Plastid facial mask liquid, it is spare；
（5）Sterilizing：Liposome facial mask liquid is subjected to sterilizing 5min quickly through 120-140 DEG C of sterilizing pipeline, obtains sterile fat
Plastid facial mask, it is spare；
（6）It is filling：Sterile liposome facial mask is filling in facial mask bag, sterile sealing to get.
Facial mask of the present invention mainly by 500,000 molecular weight sodium hyaluronates, 10,000 molecular weight sodium hyaluronates, xanthans, collagen,
Trimethylglycine, PEG-40, lecithin, vitamin E, Co-Q10, olive oil, allantoin, rilanit special and poly- sorb
Alcohol ester -20 is prepared.Wherein, sodium hyaluronate, hyaluronic acid, also known as uronic acid, hyaluronic acid, basic structure be by
The large-scale polysaccharide of two dissacharide units D-Glucose aldehydic acid and N-acetyl-glucosamine composition.Different from other mucopolysaccharides, it is not
Sulfur-bearing.Its hyalomitome molecule can carry 500 times or more of moisture, for the best moisturizing ingredient recognized by current, widely answer
In skin care products and cosmetics.Hyaluronic acid is shown with its unique molecular structure and physicochemical property in body a variety of heavy
The physiological function wanted, such as lubricating joint adjust the permeability of vascular wall, regulatory protein matter, Water-Electrolyte diffusion and operating, promote
Wound healing etc..Particular, it is important that hyaluronic acid has special water retention, it is moisture retention in presently found nature
Best substance, is referred to as ideal natural moisturizing factor, and hyaluronic acid is a kind of multi-functional matrix, hyaluronic acid（Sodium hyaluronate）
HA is distributed widely in partes corporis humani position.Wherein skin also contains a large amount of hyaluronic acid.Human skin maturation and ageing process
With hyaluronic acid content and metabolism and change, it can improve skin-nourishing be metabolized, make skin it is tender, it is smooth, go
Wrinkle increases elasticity, prevents aging, is good skin penetration enhancer again while moisturizing.Coordinate with other nutritional ingredients
It uses, the more preferable effect for promoting nutrient absorption can be played.Xanthans, Xanthan gum, also known as yellow glue, xanthan gum are yellow
Unit cell polysaccharide, be it is a kind of by false xanthomonas fermentation generate monospore polysaccharide, by cabbage black rot xanthomonas campestris with
Carbohydrate is primary raw material, through aerobic fermentation biotechnology, cuts off 1,6- glycosidic bonds, after opening branch, by 1,
4- is bonded to a kind of extracellular heteroglycan of acidity of straight chain composition.Xanthans is that collection is thickened, suspended, emulsification, stablizing in the world at present
In the biogum got in integrated best performances.The molecular side chain end of xanthans contains the number of pyruvic acid group, to its performance
Have a significant impact.Xanthans has the general performance of long chain macromolecule, but it contains more functional group than general macromolecule,
Special performance can be shown under specified conditions.Its conformation in aqueous solution is various, and different characteristics is not showed under the conditions of.
It is used as the stabilizer, thickening agent and processing paving auxiliary agent of a variety of purposes in the industry, including makes canned and bottled food, bakery
Food, dairy produce, frozen food, salad flavouring, beverage, brewing, candy, cake pattern are with product etc..When making food, it is easy to
Flowing, is easy to pour out and pour into, and is easy to pipeline, reduces energy consumption.Collagen, collagen are boiomacromolecule, animal
Main component in connective tissue, and content is most in the mammalian body, is distributed most wide functional protein, and it is total to account for protein
The 25%~30% of amount, certain organisms are even as high as 80% or more.Collagen because with good biocompatibility, can biology
Degradability and bioactivity, therefore be widely applied in fields such as food, medicine, organizational project, cosmetics.In such as
The traditional collagen health products " donkey-hide gelatin " of state, mainly using donkey hide as raw material（It is exactly contained collagen in donkey hide in fact）, have
Higher nourishing health function has the good reputation of one of Chinese medicine Triratna.Collagen is extracted by Animal Skin, in skin in addition to collagen
Also contain the proteoglycans such as hyaluronic acid, chondroitin sulfate, they contain a large amount of polar groups, are moisturizing factors, and have prevention
Tyrosine in skin is converted into the effect of melanin, therefore collagen has the effects that pure natural moisturizing, whitening, wrinkle resistant, nti-freckle,
It can be widely applied in cosmetic products.Chemical composition, the structure of collagen impart it be beauty basis.Collagen with
The structure of human skin collagen is similar, contains glycoprotein for non-soluble fiber shape, rich in a large amount of amino acid and hydrophilic in molecule
Base has certain surface-active and good compatibility, simultaneously because contain a large amount of hydroxyl in its molecule, therefore it has
Fairly good moisture-keeping function.In relative humidity 70%, the moisture of its own weight 45% can be still kept.Experiment proves：0.01%
The pure solution of collagen can form water conservation layer well, the required whole moisture of supply skin.Trimethylglycine
Betaine (Trimethylglycine), also known as glycine betaine, glycine betaine, be good moisturizer, antistatic agent, thickening agent,
Viscosity-control additive.Trimethylglycine has improving eyesight, anti-fatty liver, protection kidney, the cardiovascular disease such as treatment atherosclerosis
The effects that sick, is used for health food.Food service industry because of its moderate taste, colourless have extensive use in food, beverage.For
Weight-reducing, beauty food.Additive as daily chemical product.PEG-40, i.e. polyethylene glycol -40, nontoxic, nonirritant, taste
Slight bitter has good water solubility, and has good intermiscibility with many organic matter components.With excellent lubricity, moisturizing
Property, dispersibility, bonding agent, antistatic agent and softening agent etc., in cosmetics, pharmacy, chemical fibre, rubber, plastics, papermaking, paint, electricity
There is extremely wide application in the industries such as plating, pesticide, intermetallic composite coating and food processing.Lecithin, lecithin are known as
With protein, vitamin " third nutrient " arranged side by side, lecithin is the indispensable substance of each cell of human body, if lacked
It is weary, the power of regeneration of Skin Cell will be reduced, leads to pachylosis, have wrinkle.As can lecithin is suitably absorbed, skin regeneration
Vigor can ensure, add the good hydrophily of lecithin and lipophile, and skin is certainly just glossy.In addition, lecithin
The main nutrient of inositol or hair contained by fat, can inhibit alopecia, make white hair slowly blackening.Vitamin E（Vitamin E）
It is a kind of liposoluble vitamin, hydrolysate is tocopherol, is one of most important antioxidant, is dissolved in fat and ethyl alcohol etc.
It is not soluble in water in organic solvent, heat, acid are stablized, unstable to alkali, sensitive to oxygen, to hot insensitive, the eighties, medicine is special
Family find, the mankind can cause genetic disease and metabolic disease if having lacked vitamin E.With going deep into for research,
Medical expert recognizes vitamin E in prevention cardiovascular and cerebrovascular disease, tumour, diabetes and other complication, central nervous system again
Disease, motor system disease, skin disease etc. unite with extensive effect.Co-Q10, COENZYME Q10 are a kind of
Fat-soluble antioxidant, can human activin cell and cellular energy nutrition, have improve the immunity of the human body, enhance it is anti-oxidant,
It slows down aging and enhances the functions such as human activity, be medically widely used in disease of cardiovascular system, use it for extensively both at home and abroad
Nutrient and healthcare products and food additives.Part experiment shows to resist the oxidations such as ultraviolet light with the increase skin collagen at age
The ability of stimulant damage declines, and Co-Q10, which is used for a long time, can effectively prevent skin light decay old, reduce circumference of eyes
Wrinkle can under the assistance of Tocopherol because Co-Q10 penetrates into skin growth layer and can weaken the oxidation reaction of photon
To start the phosphorylated tyrosine kinase of specificity, the oxidative damage of DNA is prevented, inhibits ultraviolet light human skin at fiber
The expression of mother cell Collagenase protects the skin from damage.Co-Q10 anti-lipid peroxidation is thought in extensive research
Reaction, reduces the generation of free radical, protects the activated centres SOD and its structure from Free radicals injury, improve internal SOD etc.
Enzymatic activity inhibits the Apoptosis of response to oxidative stress induction, has the function of significant anti-oxidant, anti-aging.Olive oil
It is made of the fresh direct cold press of olive fruit, not heated and chemical treatment remains natural nutrient component.Olive
Oil is considered as the grease that human nutrition is most suitable in the grease found so far.Allantoin, Allantoin are a kind of nothings
Poison, tasteless and nonirritant, without hypersensitive white crystal, crystallization is single prism or colorless crystalline powder in water.It can be dissolved in
Hot water, hot alcohol and diluted sodium hydroxide solution.It is slightly soluble in the water and alcohol of room temperature, is insoluble in the organic solvents such as ether and chloroform；It is full
(a concentration of 0.6%) is in subacidity with aqueous solution；PH is 5.5.Stablize in the aqueous solution that pH value is 4-9.In nonaqueous solvents
With also stablize in dry air；Decomposable asymmetric choice net under boiling and be exposed to sunlight in strong alkali solution.Since allantoin is a kind of both sexes
Compound, can in conjunction with many kinds of substance formed double salt, have be protected from light, sterilization and anticorrosion, analgesic, antioxidation, skin can be made to keep
Moisture content moistens and soft, is the additive of the cosmetics such as cosmetology, is widely used in freckle cream, anti-acne toner, shampoo, perfume (or spice)
The additive of soap, toothpaste, shaving lotion, conditioner, astringent, anti-sweat deodorization lotion etc..The cosmetics of addition allantoin have
Protective tissue, hydrophilic, the effects that absorbing water and preventing moisture from distributing；Hair-cream, hair cream, the shampoo for adding allantoin, there is hair
Protective effect can make hair not bifurcated, constantly hair；Lipstick, the face cream of addition allantoin can make skin, lip soft and rich in bullets
Property, and have beautiful gloss.Allantoin promotes tissue growth, cell metabolism, cutin-softening layer albumen.Rilanit special,
The effects that Hydrogenated castor oil, pharmaceutic adjuvant, this product plays thickening, hardening and sustained release in the formulation, therefore as increasing
Thick dose, hardening agent and sustained release agent are used to prepare semisolid preparation and solid pharmaceutical preparation, such as ointment, suppository, pill, tablet.It is poly-
Sorbitol ester -20, the polysorbate containing 20 ethylene oxide units are hydrophilic non-ionic surfactants, are widely used as stablizing
Oil-in-water pharmaceutical emulsion emulsifier.
Facial mask is made in the above material combination, has Transdermal absorption effect good, moistening effect is good, uses the spies such as no discomfort
Point is used for a long time moreover it is possible to desalinate microgroove, moisturizing, skin can be made delicate, glossy, high resilience.
In addition, facial mask of the present invention utilizes advanced superhigh pressure technique, pass through rational prescription.Realize general facial mask institute not
The effect being carried out at the same time is nourished in the moisturizing having.Applicant is by adjusting using oil soluble material and water-soluble substances as raw material, super
Under conditions of high-pressure homogeneous, the bead that oil soluble material impact is nanometer shape has been connect with water-soluble substances by emulsifier
Come.Form oil-in-water nano liposomes bead.To solve the problems, such as Transdermal absorption and comfort.
Clinical observation research is carried out to facial mask of the present invention, the provable present invention has beneficial effect：
1. moisturizing Journal of Sex Research
By 20 ages facial mask of the present invention is used in 25-45 Sui women（It is prepared by embodiment 1）24 hours faces afterwards
The variation of portion's water content.Following data is obtained after average, is shown in Table 1.
Data above be use and the person of being not used in 24 hours without being obtained after other moisturizings and the operations such as wash one's face.
2. pore Changeement
Take the questionnaire survey of subjective feeling.40 interviewed at random, women of the age between 33-48 Sui, 89% women
Feedback is using facial mask of the present invention（It is prepared by embodiment 2）After a week, face obviously attenuates.5% interviewed women feedback, which has, to be changed
Kind effect.6% interviewed women expression is not improved.
3. the variation of fine wrinkles
It improves significantly to crow's foot.Observation on probation is carried out to 20 30-50 Sui canthus women wrinkly,
It is used for a long time 1 month, more can significantly improve the dry line of eye and fine wrinkles.On the one hand, this facial mask has repairs water shortage completely
Dry line caused by and, on the other hand, liposoluble substance can enter under epidermis, and collagen is promoted to be formed, on a month left side
The right effect realized microgroove and obviously disappeared.
Some cases are as follows：
1. Mr. Wang, female, 40 years old, canthus had wrinkle apparent, it is specifically shown in Fig. 1, after being used for a long time one month, eye wrinkle-removing is apparent
Attenuate, is specifically shown in Fig. 2.
2. Lee, female, 45 years old, canthus had wrinkle and dry line apparent, it is specifically shown in Fig. 3, after being used for a long time one month, eye wrinkle
Line obviously attenuates, and dry line is obviously improved, and is specifically shown in Fig. 4.
Result above proves, facial mask of the present invention is with good with Transdermal absorption effect, and moistening effect is good, and use is relaxed invariably
The features such as suitable sense, is used for a long time moreover it is possible to desalinate microgroove, moisturizing, skin can be made delicate, glossy, high resilience.
Compared with prior art, facial mask Transdermal absorption effect of the present invention is good, and moistening effect is good, uses no discomfort.And
Manufacture craft is simple.
Description of the drawings：
Fig. 1 is that Mr. Wang uses preceding eye figure；
Fig. 2 is Mr. Wang's eye figure after 1 month；
Fig. 3 is that Lee uses preceding eye figure；
Fig. 4 is Mr. Wang's eye figure after 1 month.
It further illustrates the present invention by the following examples, but not as limitation of the present invention
Specific implementation mode
Embodiment 1：
Prescription：500000 molecular weight sodium hyaluronate 1.5g, 10,000 molecular weight sodium hyaluronate 0.5g, xanthans 0.5g, collagen 10g,
Trimethylglycine 2g, PEG-40 10g, lecithin 10g, vitamin E 5g, Co-Q10 10g, olive oil 50g, allantoin
10g, rilanit special 5g and -20 1g of polysorbate.
Technique：
（1）Take 500,000 molecular weight sodium hyaluronates, 10,000 molecular weight sodium hyaluronates, xanthans, collagen, trimethylglycine and
500ml purified waters are added in PEG-40, and stirring and dissolving in course of dissolution, controlled at 40-45 DEG C, obtains water phase, spare；
（2）Lecithin, vitamin E, Co-Q10, olive oil, allantoin, rilanit special and polysorbate -20 are taken,
After stirring and evenly mixing, 30min is heated at 55-65 DEG C, is completely dissolved, obtains oil phase, it is spare；
（3）At 55-65 DEG C, 100ml purified waters are added into oil phase, after dispersion, under the conditions of 1000Bar-1500Bar,
Homogeneous operates 3 times, obtains nanometer grade liposome, spare；
（4）Nanometer grade liposome is imported in water phase, under stirring condition plus purified water is to 1000ml, and mixing obtains liposome
Facial mask liquid, it is spare；
（5）Sterilizing：Liposome facial mask liquid is subjected to sterilizing 5min quickly through 120-140 DEG C of sterilizing pipeline, obtains sterile fat
Plastid facial mask, it is spare；
（6）It is filling：Sterile liposome facial mask is filling in facial mask bag, sterile sealing to get.
Application method：First cleaning face, takes facial mask appropriate, equably applies on the face, is cleaned after 20-30 minutes, often
It is 1-3 times all.
Embodiment 2：
Prescription：500000 molecular weight sodium hyaluronate 2g, 10,000 molecular weight sodium hyaluronate 0.8g, xanthans 0.8g, collagen 12g, three
Methylglycine 2.5g, PEG-4012g, lecithin 12g, vitamin E 8g, Co-Q10 12g, olive oil 55g, allantoin
12g, rilanit special 8g and -20 1.2g of polysorbate.
Technique：（1）Take 500,000 molecular weight sodium hyaluronates, 10,000 molecular weight sodium hyaluronates, xanthans, collagen, the sweet ammonia of trimethyl
550ml purified waters are added in acid and PEG-40, and stirring and dissolving in course of dissolution, controlled at 40-45 DEG C, obtains water phase, spare；
（2）Lecithin, vitamin E, Co-Q10, olive oil, allantoin, rilanit special and polysorbate -20 are taken,
After stirring and evenly mixing, 25-35min is heated at 55-65 DEG C, is completely dissolved, obtains oil phase, it is spare；
（3）At 55-65 DEG C, 120ml purified waters are added into oil phase, after dispersion, under the conditions of 1000Bar-1500Bar,
Homogeneous operates 2 times, obtains nanometer grade liposome, spare；
（4）Nanometer grade liposome is imported in water phase, under stirring condition plus purified water is to 1200ml, and mixing obtains liposome
Facial mask liquid, it is spare；
（5）Sterilizing：Liposome facial mask liquid is subjected to sterilizing 10min quickly through 120-140 DEG C of sterilizing pipeline, obtains sterile fat
Plastid facial mask, it is spare；
（6）It is filling：Sterile liposome facial mask is filling in facial mask bag, sterile sealing to get.
Application method：First cleaning face, takes facial mask appropriate, equably applies on the face, is cleaned after 30 minutes, weekly 1-
3 times.
Embodiment 3：
Prescription：500000 molecular weight sodium hyaluronate 1g, 10,000 molecular weight sodium hyaluronate 0.2g, xanthans 0.2g, collagen 8g, three
Methylglycine 1.5g, PEG-40 8g, lecithin 8g, vitamin E 2g, Co-Q10 8g, olive oil 45g, allantoin 8g,
Rilanit special 2g and polysorbate -200.8g.
Technique：
（1）Take 500,000 molecular weight sodium hyaluronates, 10,000 molecular weight sodium hyaluronates, xanthans, collagen, trimethylglycine and
450ml purified waters are added in PEG-40, and stirring and dissolving in course of dissolution, controlled at 40-45 DEG C, obtains water phase, spare；
（2）Lecithin, vitamin E, Co-Q10, olive oil, allantoin, rilanit special and polysorbate -20 are taken,
After stirring and evenly mixing, 25min is heated at 55-65 DEG C, is completely dissolved, obtains oil phase, it is spare；
（3）At 55-65 DEG C, 80ml purified waters are added into oil phase, after dispersion, under the conditions of 1000Bar-1500Bar,
Matter operates 2 times, obtains nanometer grade liposome, spare；
（4）Nanometer grade liposome is imported in water phase, under stirring condition plus purified water is to 800ml, and mixing obtains lipid dignity
Film liquid, it is spare；
（5）Sterilizing：Liposome facial mask liquid is subjected to sterilizing 1min quickly through 120-140 DEG C of sterilizing pipeline, obtains sterile fat
Plastid facial mask, it is spare；
（6）It is filling：Sterile liposome facial mask is filling in facial mask bag, sterile sealing to get.
Application method：First cleaning face, takes facial mask appropriate, equably applies on the face, cleans after twenty minutes, weekly 1-
3 times.
Claims (6)
1. a kind of nano liposomes facial mask, it is characterised in that：It calculates by weight, mainly by 500,000 molecular weight sodium hyaluronate 0.1-3
Part, 0.05-1.0 parts of 10,000 molecular weight sodium hyaluronate, 0.05-1.0 parts of xanthans, 5-15 parts of collagen, trimethylglycine 1-3
Part, 5-15 parts of PEG-40,5-15 parts of lecithin, 1-10 parts of vitamin E, 5-15 parts of Co-Q10,40-60 parts of olive oil, urine
- 20 0.5-1.5 parts of 5-15 parts of Bursin, 1-10 parts of rilanit special and polysorbate are prepared.
2. nano liposomes facial mask as described in claim 1, it is characterised in that：It calculates by weight, it is mainly sub very much by 50
Measure 1-2 parts of sodium hyaluronate, 0.2-0.8 parts of 10,000 molecular weight sodium hyaluronate, 0.2-0.8 parts of xanthans, 8-12 parts of collagen, trimethyl
1.5-2.5 parts of glycine, 8-12 parts of PEG-40,8-12 parts of lecithin, 2-8 parts of vitamin E, 8-12 parts of Co-Q10, olive
- 20 0.8-1.2 parts of 45-55 parts oily, 8-12 parts of allantoin, 2-8 parts of rilanit special and polysorbate are prepared.
3. nano liposomes facial mask as claimed in claim 2, it is characterised in that：It calculates by weight, it is mainly sub very much by 50
Measure 1.5 parts of sodium hyaluronate, 0.5 part of 10,000 molecular weight sodium hyaluronate, 0.5 part of xanthans, 10 parts of collagen, 2 parts of trimethylglycine,
10 parts of PEG-40,10 parts of lecithin, 5 parts of vitamin E, 10 parts of Co-Q10,50 parts of olive oil, 10 parts of allantoin, hydrogenation castor
1 part of 5 parts of sesame oil and polysorbate -20 are prepared.
4. a kind of preparation method of nano liposomes facial mask as claimed in any one of claims 1-3, it is characterised in that：Including
Following steps：
（1）Take 500,000 molecular weight sodium hyaluronates, 10,000 molecular weight sodium hyaluronates, xanthans, collagen, trimethylglycine and PEG-
40, purified water is added, stirring and dissolving obtains water phase, spare；
（2）Lecithin, vitamin E, Co-Q10, olive oil, allantoin, rilanit special and polysorbate -20 are taken, is stirred
Mixing, heating obtains oil phase until be completely dissolved, spare；
（3）Purified water is added into oil phase, disperses, homogeneous operation obtains nanometer grade liposome, spare；
（4）Nanometer grade liposome is imported in water phase, purified water is added under stirring condition, mixing obtains liposome facial mask liquid, spare；
（5）Sterilizing：Liposome facial mask liquid is sterilized quickly through 120-140 DEG C of sterilizing pipeline, obtains sterile liposome facial mask,
It is spare；
（6）It is filling：Sterile liposome facial mask is filling in facial mask bag, sterile sealing to get.
5. the preparation method of nano liposomes facial mask as claimed in claim 4, it is characterised in that：Include the following steps：
（1）Take 500,000 molecular weight sodium hyaluronates, 10,000 molecular weight sodium hyaluronates, xanthans, collagen, trimethylglycine and PEG-
40,450-550 parts by volume purified waters are added, stirring and dissolving in course of dissolution, controlled at 40-45 DEG C, obtains water phase, spare；
（2）Lecithin, vitamin E, Co-Q10, olive oil, allantoin, rilanit special and polysorbate -20 are taken, is stirred
After mixing, 25-35min is heated at 55-65 DEG C, is completely dissolved, obtains oil phase, it is spare；
（3）At 55-65 DEG C, 80-120 parts by volume purified waters are added into oil phase, after dispersion, in 1000Bar-1500Bar conditions
Under, homogeneous operates 2-3 times, obtains nanometer grade liposome, spare；
（4）Nanometer grade liposome is imported in water phase, under stirring condition plus purified water is to 800-1200 parts by volume, and mixing obtains fat
Plastid facial mask liquid, it is spare；
（5）Sterilizing：Liposome facial mask liquid is subjected to sterilizing 1-10min quickly through 120-140 DEG C of sterilizing pipeline, obtains sterile lipid
Honorable film, it is spare；
（6）It is filling：Sterile liposome facial mask is filling in facial mask bag, sterile sealing to get.
6. the preparation method of nano liposomes facial mask as claimed in claim 5, it is characterised in that：Include the following steps：
（1）Take 500,000 molecular weight sodium hyaluronates, 10,000 molecular weight sodium hyaluronates, xanthans, collagen, trimethylglycine and PEG-
40,500 parts by volume purified waters are added, stirring and dissolving in course of dissolution, controlled at 40-45 DEG C, obtains water phase, spare；
（2）Lecithin, vitamin E, Co-Q10, olive oil, allantoin, rilanit special and polysorbate -20 are taken, is stirred
After mixing, 30min is heated at 55-65 DEG C, is completely dissolved, obtains oil phase, it is spare；
（3）At 55-65 DEG C, 100 parts by volume purified waters are added into oil phase, after dispersion, under the conditions of 1000Bar-1500Bar,
Homogeneous operates 3 times, obtains nanometer grade liposome, spare；
（4）Nanometer grade liposome is imported in water phase, under stirring condition plus purified water is to 1000 parts by volume, and mixing obtains liposome
Facial mask liquid, it is spare；
（5）Sterilizing：Liposome facial mask liquid is subjected to sterilizing 5min quickly through 120-140 DEG C of sterilizing pipeline, obtains sterile liposome
Facial mask, it is spare；
（6）It is filling：Sterile liposome facial mask is filling in facial mask bag, sterile sealing to get.
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| CN107233283A (en) * | 2017-07-06 | 2017-10-10 | 贵州九立德生物制药有限公司 | A kind of elimination pouch, hydrogel of wrinkle and preparation method thereof |
| CN107412017A (en) * | 2017-07-06 | 2017-12-01 | 贵州九立德生物制药有限公司 | It is a kind of to help to rebuild liposome liquid of skin barrier layer and preparation method thereof |
| CN107496179A (en) * | 2017-09-26 | 2017-12-22 | 山东安陶生物科技有限公司 | A kind of facial mask for adding saualane and preparation method thereof |
| CN111643403A (en) * | 2020-07-17 | 2020-09-11 | 贵州九立德生物制药有限公司 | Amino acid soft cleanser and preparation method thereof |
| CN111991252A (en) * | 2020-09-25 | 2020-11-27 | 烟台硕人生物科技有限公司 | Coenzyme Q10 and brown algae oligosaccharide nutrition and moisture mask preparation method |
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