CN110755679A - Liquid dressing for laser operation and preparation method thereof - Google Patents
Liquid dressing for laser operation and preparation method thereof Download PDFInfo
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- CN110755679A CN110755679A CN201911124703.4A CN201911124703A CN110755679A CN 110755679 A CN110755679 A CN 110755679A CN 201911124703 A CN201911124703 A CN 201911124703A CN 110755679 A CN110755679 A CN 110755679A
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The invention provides a liquid dressing for use after laser surgery and a preparation method thereof, and relates to the technical field of medical dressing production. The liquid dressing is prepared from the following raw materials in parts by weight: 3.5-15.0 parts of sodium hyaluronate I, 0.1-1.0 part of sodium hyaluronate II, 0.04-0.20 part of amino acid, 1-5 parts of trehalose, 0.5-4.0 parts of nicotinamide, 0-6 parts of blending auxiliary agent, 0.2-1.0 part of sodium dihydrogen phosphate, 1-2 parts of disodium hydrogen phosphate, 5-10 parts of sodium chloride and 1100 parts of deionized water. The invention overcomes the defects of the prior art, not only can effectively improve the moisturizing effect of the dressing, reduce the sensitivity of postoperative wound cells to inflammatory factors and has good anti-inflammatory effect, but also can effectively relieve pain and itching of the postoperative wound, simultaneously can effectively prevent aging and oxidation of cells, promotes regeneration of the cells, is beneficial to recovery of the wound, has short recovery period and is suitable for popularization.
Description
Technical Field
The invention relates to the technical field of medical dressing production, in particular to a liquid dressing used after laser surgery and a preparation method thereof.
Background
Nowadays, laser surgery is often performed for diseases and the like. The laser operation is to use a carbon dioxide luminotron to emit high-power light to act on pathological tissues, so that inflammation can be absorbed to destroy tumors, and the low power can remove spots and beautify the skin. In beautifying the skin, the effect of some patients after the operation is not ideal or the complications occur. To prevent such situations, medical personnel often use liquid dressings to disinfect their skin after surgery.
However, the existing liquid dressing has the disadvantages of unsatisfactory use effect, limited anti-inflammation degree and incapability of effectively promoting the recovery of wound surfaces, so that the recovery period after operation is long, and great troubles are brought to users.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the liquid dressing for the laser operation and the preparation method thereof, the invention overcomes the defects of the prior art, not only can effectively improve the moisturizing effect of the dressing, reduce the sensitivity of wound cells after the operation to inflammatory factors and has good anti-inflammatory effect, but also can effectively relieve pain and itching of the wound after the operation, simultaneously can effectively prevent aging and oxidation of cells, promote the regeneration of cells, is beneficial to the recovery of the wound, has short recovery period and is suitable for popularization.
In order to achieve the above purpose, the technical scheme of the invention is realized by the following technical scheme:
a liquid dressing for use after laser surgery is prepared from the following raw materials in parts by weight: 3.5-15.0 parts of sodium hyaluronate I, 0.1-1.0 part of sodium hyaluronate II, 0.04-0.20 part of amino acid, 1-5 parts of trehalose, 0.5-4.0 parts of nicotinamide, 0-6 parts of blending auxiliary agent, 0.2-1.0 part of sodium dihydrogen phosphate, 1-2 parts of disodium hydrogen phosphate, 5-10 parts of sodium chloride and 1100 parts of deionized water;
the preparation method of the blending auxiliary agent comprises the following steps:
(1) mixing ethyl p-aminobenzoate and triple helix active collagen, adding into a magnetic stirrer, adding deionized water with 6-10 times of volume, and stirring at room temperature at a rotating speed of 55-65r/min for 15-25 min;
(2) adding vitamin C ethyl ether, rhodanolic acid and tretinoin into the magnetic stirrer in the step (1), continuously stirring for 20-30min, pouring the mixture into a water bath kettle, heating in water bath at the temperature of 42-48 ℃, and carrying out heat preservation reaction for 15-20 min;
(3) pouring the mixture reacted in the step (2) into an ultrasonic oscillator, adding resveratrol, bamboo leaf flavone and phycocyanin, carrying out ultrasonic oscillation for 25-40min, placing the mixture into a refrigerator, and freezing at-35 ℃ to-25 ℃ until the water content is 10-15% to obtain the blending aid.
Preferably, the molecular weight of the sodium hyaluronate I is 100-200 ten thousand, and the molecular weight of the sodium hyaluronate II is 0.5-2 ten thousand.
Preferably, the amino acid is formed by mixing glycine, valine, alanine, threonine and lysine in a mass ratio of 1:1:1:1: 1.
Preferably, the mass ratio of ethyl p-aminobenzoate, tridecapeptide, triple helix active collagen, vitamin C ethyl ether, rhodanolic acid, tretinoin, resveratrol, bamboo leaf flavonoid and phycocyanin is 5:3:4:2:1:1:2:2: 1.
The preparation method of the liquid dressing comprises the following steps:
(1) mixing sodium hyaluronate I, sodium hyaluronate II, amino acid, sodium dihydrogen phosphate, disodium hydrogen phosphate and sodium chloride, adding into a stirring tank, stirring at normal temperature, sealing and standing for a period of time for later use;
(2) mixing trehalose, nicotinamide and a blending auxiliary agent, adding into the stirring tank in the step (2), and uniformly stirring to obtain a dressing raw material for later use;
(3) adding the prepared raw materials into a feeding tank of a magnetic stirring kettle, adding deionized water into the magnetic stirring kettle, slowly dropwise adding the raw materials in the feeding pipe, stirring and dissolving at normal temperature, continuously stirring for a period of time after all the raw materials are added, and standing for later use;
(4) and (4) performing ultraviolet sterilization on the mixture obtained in the step (3), and sealing and storing the sterilized mixture to obtain the product.
Preferably, in the step (1), the stirring speed is 80-90r/min, and the sealing and standing time is 1-1.5 h.
Preferably, the stirring speed in the step (3) is 120r/min, the stirring time is 20-30min after all the raw materials are added, and the standing preservation time is 40-60 min.
The invention provides a liquid dressing for laser operation and a preparation method thereof, and compared with the prior art, the liquid dressing has the advantages that:
(1) according to the invention, sodium hyaluronate I, sodium hyaluronate II, amino acid, trehalose and nicotinamide are used as main components of the liquid dressing, so that the moisturizing effect of the dressing can be effectively improved, the stress resistance of skin cells on a postoperative wound surface is further increased, the sensitivity of the cells to inflammatory factors is reduced, the anti-inflammatory effect is good, the recovery of the wound surface is facilitated, and the postoperative recovery period is short;
(2) the invention is added with the blending auxiliary agent, adopts ethyl aminobenzoate, tridecapeptide, triple helix active collagen, vitamin C ethyl ether, rhodanolic acid, vitamin A acid, resveratrol, bamboo leaf flavonoid, phycocyanin and other raw materials, can effectively relieve pain and itching of the wound surface after operation, can also effectively prevent aging and oxidation of skin cells on the wound surface, further promotes regeneration of the wound surface cells, has good postoperative repair effect, and is suitable for popularization.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention are clearly and completely described below in conjunction with the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
a liquid dressing for use after laser surgery is prepared from the following raw materials in parts by weight: 3.5 parts of sodium hyaluronate I, 0.1 part of sodium hyaluronate II, 0.04 part of amino acid, 1 part of trehalose, 0.5 part of nicotinamide, 0.2 part of sodium dihydrogen phosphate, 1 part of disodium hydrogen phosphate, 5 parts of sodium chloride and 1000 parts of deionized water.
Wherein the molecular weight of the sodium hyaluronate I is 100-200 ten thousand, and the molecular weight of the sodium hyaluronate II is 0.5-2 ten thousand; the amino acid is formed by mixing glycine, valine, alanine, threonine and lysine in a mass ratio of 1:1:1:1: 1; the mass ratio of ethyl p-aminobenzoate to tridecapeptide to triple helix active collagen to vitamin C ethyl ether to rhodamine phenolic acid to tretinoin to resveratrol to bamboo leaf flavonoid to phycocyanin is 5:3:4:2:1:1:2:2: 1.
The preparation method of the liquid dressing comprises the following steps:
(1) mixing sodium hyaluronate I, sodium hyaluronate II, amino acid, sodium dihydrogen phosphate, disodium hydrogen phosphate and sodium chloride, adding into a stirring tank, stirring at normal temperature, sealing and standing for a period of time for later use;
(2) mixing trehalose and nicotinamide, adding into the stirring tank in the step (2), and uniformly stirring to obtain a dressing raw material for later use;
(3) adding the prepared raw materials into a feeding tank of a magnetic stirring kettle, adding deionized water into the magnetic stirring kettle, slowly dropwise adding the raw materials in the feeding pipe, stirring and dissolving at normal temperature, continuously stirring for a period of time after all the raw materials are added, and standing for later use;
(4) and (4) performing ultraviolet sterilization on the mixture obtained in the step (3), and sealing and storing the sterilized mixture to obtain the product.
Wherein, the stirring speed in the step (1) is 80-90r/min, and the sealing and standing time is 1-1.5 h; the stirring speed in the step (3) is 100-120r/min, the stirring time is 20-30min after all the raw materials are added, and the standing and storing time is 40-60 min.
Example 2:
a liquid dressing for use after laser surgery is prepared from the following raw materials in parts by weight: 9.5 parts of sodium hyaluronate I, 0.6 part of sodium hyaluronate II, 0.12 part of amino acid, 3 parts of trehalose, 2.5 parts of nicotinamide, 3 parts of blending auxiliary agent, 0.6 part of sodium dihydrogen phosphate, 1.5 parts of disodium hydrogen phosphate, 7.5 parts of sodium chloride and 1050 parts of deionized water.
The preparation method of the blending auxiliary agent comprises the following steps:
(1) mixing ethyl p-aminobenzoate and triple helix active collagen, adding into a magnetic stirrer, adding deionized water with 6-10 times of volume, and stirring at room temperature at a rotating speed of 55-65r/min for 15-25 min;
(2) adding vitamin C ethyl ether, rhodanolic acid and tretinoin into the magnetic stirrer in the step (1), continuously stirring for 20-30min, pouring the mixture into a water bath kettle, heating in water bath at the temperature of 42-48 ℃, and carrying out heat preservation reaction for 15-20 min;
(3) pouring the mixture reacted in the step (2) into an ultrasonic oscillator, adding resveratrol, bamboo leaf flavone and phycocyanin, carrying out ultrasonic oscillation for 25-40min, placing the mixture into a refrigerator, and freezing at-35 ℃ to-25 ℃ until the water content is 10-15% to obtain the blending aid.
Wherein the molecular weight of the sodium hyaluronate I is 100-200 ten thousand, and the molecular weight of the sodium hyaluronate II is 0.5-2 ten thousand; the amino acid is formed by mixing glycine, valine, alanine, threonine and lysine in a mass ratio of 1:1:1:1: 1; the mass ratio of ethyl p-aminobenzoate to tridecapeptide to triple helix active collagen to vitamin C ethyl ether to rhodamine phenolic acid to tretinoin to resveratrol to bamboo leaf flavonoid to phycocyanin is 5:3:4:2:1:1:2:2: 1.
The preparation method of the liquid dressing comprises the following steps:
(1) mixing sodium hyaluronate I, sodium hyaluronate II, amino acid, sodium dihydrogen phosphate, disodium hydrogen phosphate and sodium chloride, adding into a stirring tank, stirring at normal temperature, sealing and standing for a period of time for later use;
(2) mixing trehalose, nicotinamide and a blending auxiliary agent, adding into the stirring tank in the step (2), and uniformly stirring to obtain a dressing raw material for later use;
(3) adding the prepared raw materials into a feeding tank of a magnetic stirring kettle, adding deionized water into the magnetic stirring kettle, slowly dropwise adding the raw materials in the feeding pipe, stirring and dissolving at normal temperature, continuously stirring for a period of time after all the raw materials are added, and standing for later use;
(4) and (4) performing ultraviolet sterilization on the mixture obtained in the step (3), and sealing and storing the sterilized mixture to obtain the product.
Wherein, the stirring speed in the step (1) is 80-90r/min, and the sealing and standing time is 1-1.5 h; the stirring speed in the step (3) is 100-120r/min, the stirring time is 20-30min after all the raw materials are added, and the standing and storing time is 40-60 min.
Example 3:
a liquid dressing for use after laser surgery is prepared from the following raw materials in parts by weight: 15.0 parts of sodium hyaluronate I, 1.0 part of sodium hyaluronate II, 0.20 part of amino acid, 5 parts of trehalose, 4.0 parts of nicotinamide, 6 parts of blending auxiliary agent, 1.0 part of sodium dihydrogen phosphate, 2 parts of disodium hydrogen phosphate, 10 parts of sodium chloride and 1100 parts of deionized water.
The preparation method of the blending auxiliary agent comprises the following steps:
(1) mixing ethyl p-aminobenzoate and triple helix active collagen, adding into a magnetic stirrer, adding deionized water with 6-10 times of volume, and stirring at room temperature at a rotating speed of 55-65r/min for 15-25 min;
(2) adding vitamin C ethyl ether, rhodanolic acid and tretinoin into the magnetic stirrer in the step (1), continuously stirring for 20-30min, pouring the mixture into a water bath kettle, heating in water bath at the temperature of 42-48 ℃, and carrying out heat preservation reaction for 15-20 min;
(3) pouring the mixture reacted in the step (2) into an ultrasonic oscillator, adding resveratrol, bamboo leaf flavone and phycocyanin, carrying out ultrasonic oscillation for 25-40min, placing the mixture into a refrigerator, and freezing at-35 ℃ to-25 ℃ until the water content is 10-15% to obtain the blending aid.
Wherein the molecular weight of the sodium hyaluronate I is 100-200 ten thousand, and the molecular weight of the sodium hyaluronate II is 0.5-2 ten thousand; the amino acid is formed by mixing glycine, valine, alanine, threonine and lysine in a mass ratio of 1:1:1:1: 1; the mass ratio of ethyl p-aminobenzoate to tridecapeptide to triple helix active collagen to vitamin C ethyl ether to rhodamine phenolic acid to tretinoin to resveratrol to bamboo leaf flavonoid to phycocyanin is 5:3:4:2:1:1:2:2: 1.
The preparation method of the liquid dressing comprises the following steps:
(1) mixing sodium hyaluronate I, sodium hyaluronate II, amino acid, sodium dihydrogen phosphate, disodium hydrogen phosphate and sodium chloride, adding into a stirring tank, stirring at normal temperature, sealing and standing for a period of time for later use;
(2) mixing trehalose, nicotinamide and a blending auxiliary agent, adding into the stirring tank in the step (2), and uniformly stirring to obtain a dressing raw material for later use;
(3) adding the prepared raw materials into a feeding tank of a magnetic stirring kettle, adding deionized water into the magnetic stirring kettle, slowly dropwise adding the raw materials in the feeding pipe, stirring and dissolving at normal temperature, continuously stirring for a period of time after all the raw materials are added, and standing for later use;
(4) and (4) performing ultraviolet sterilization on the mixture obtained in the step (3), and sealing and storing the sterilized mixture to obtain the product.
Wherein, the stirring speed in the step (1) is 80-90r/min, and the sealing and standing time is 1-1.5 h; the stirring speed in the step (3) is 100-120r/min, the stirring time is 20-30min after all the raw materials are added, and the standing and storing time is 40-60 min.
Example 4:
the using effect of the common liquid dressing on the market and the liquid dressings obtained in examples 1 to 3 was tested, the common liquid dressing on the market was set as a control group, and the liquid dressings prepared in examples 1 to 3 were set as experimental groups 1 to 3, and the testing method was as follows:
(1) selecting 40 patients with the same health condition and who just have undergone facial laser surgery, evenly dividing the patients into four groups, correspondingly using 4 liquid dressings to provide the same living environment and diet for each group of patients, and spraying the liquid dressings for each group of patients three times per day, wherein the spraying amount is equal for each time;
(2) the recovery of the skin of the back of 4 groups of patients using the liquid dressings 1d, 2d and 3d was examined, and the recovery was evaluated in four grades of "A, B, C and D", and the specific examination results are shown in the following table:
as can be seen from the above table, the liquid dressings prepared in examples 1 to 3 have higher anti-inflammatory, moisture retention and healing degrees than those of the conventional liquid dressings, and have faster anti-inflammatory and healing effects and a shorter recovery period when being used by a patient, and the liquid dressings prepared in example 2 have the best use effects.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (7)
1. The liquid dressing for post-laser surgery is characterized by being prepared from the following raw materials in parts by weight: 3.5-15.0 parts of sodium hyaluronate I, 0.1-1.0 part of sodium hyaluronate II, 0.04-0.20 part of amino acid, 1-5 parts of trehalose, 0.5-4.0 parts of nicotinamide, 0-6 parts of blending auxiliary agent, 0.2-1.0 part of sodium dihydrogen phosphate, 1-2 parts of disodium hydrogen phosphate, 5-10 parts of sodium chloride and 1100 parts of deionized water;
the preparation method of the blending auxiliary agent comprises the following steps:
(1) mixing ethyl p-aminobenzoate and triple helix active collagen, adding into a magnetic stirrer, adding deionized water with 6-10 times of volume, and stirring at room temperature at a rotating speed of 55-65r/min for 15-25 min;
(2) adding vitamin C ethyl ether, rhodanolic acid and tretinoin into the magnetic stirrer in the step (1), continuously stirring for 20-30min, pouring the mixture into a water bath kettle, heating in water bath at the temperature of 42-48 ℃, and carrying out heat preservation reaction for 15-20 min;
(3) pouring the mixture reacted in the step (2) into an ultrasonic oscillator, adding resveratrol, bamboo leaf flavone and phycocyanin, carrying out ultrasonic oscillation for 25-40min, placing the mixture into a refrigerator, and freezing at-35 ℃ to-25 ℃ until the water content is 10-15% to obtain the blending aid.
2. The liquid dressing for laser surgery as recited in claim 1, wherein the molecular weight of the sodium hyaluronate I is 100-200 ten thousand, and the molecular weight of the sodium hyaluronate II is 0.5-2 ten thousand.
3. The liquid dressing for use after laser surgery according to claim 1, wherein the amino acid is a mixture of glycine, valine, alanine, threonine and lysine in a mass ratio of 1:1:1:1: 1.
4. The liquid dressing for laser surgery as recited in claim 1, wherein the mass ratio of ethyl p-aminobenzoate, tridecapeptide, triple helix active collagen, vitamin C ethyl ether, rhodanolic acid, tretinoin, resveratrol, bamboo leaf flavonoid and phycocyanin is 5:3:4:2:1: 2:2: 1.
5. A method for preparing a liquid dressing for use after a laser surgery, the method comprising the steps of:
(1) mixing sodium hyaluronate I, sodium hyaluronate II, amino acid, sodium dihydrogen phosphate, disodium hydrogen phosphate and sodium chloride, adding into a stirring tank, stirring at normal temperature, sealing and standing for a period of time for later use;
(2) mixing trehalose, nicotinamide and a blending auxiliary agent, adding into the stirring tank in the step (2), and uniformly stirring to obtain a dressing raw material for later use;
(3) adding the prepared raw materials into a feeding tank of a magnetic stirring kettle, adding deionized water into the magnetic stirring kettle, slowly dropwise adding the raw materials in the feeding pipe, stirring and dissolving at normal temperature, continuously stirring for a period of time after all the raw materials are added, and standing for later use;
(4) and (4) performing ultraviolet sterilization on the mixture obtained in the step (3), and sealing and storing the sterilized mixture to obtain the product.
6. The method for preparing a liquid dressing used after laser surgery according to claim 5, wherein the stirring speed in the step (1) is 80-90r/min, and the sealing standing time is 1-1.5 h.
7. The method for preparing a liquid dressing used after laser surgery as claimed in claim 5, wherein the stirring speed in step (3) is 100-120r/min, the stirring time after all the raw materials are added is 20-30min, and the standing and storing time is 40-60 min.
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| CN111956860A (en) * | 2020-09-07 | 2020-11-20 | 海南鸿翼医疗器械有限公司 | Liquid trehalose dressing for repairing skin barrier wound surface and preparation method thereof |
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