CN106728744A - A kind of composition and its preparation of the promotion anti-scar of wound healing - Google Patents
A kind of composition and its preparation of the promotion anti-scar of wound healing Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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Abstract
The present invention provides a kind of composition of the promotion anti-scar of wound healing, including following component and its parts by weight：5~10 parts of 5~10 parts of onion bulb stem extract, 0.1~3 part of Gotu Kola P.E, 1~10 part of beta glucan, 15~25 parts of chitosan oligosaccharide and catechin.The invention belongs to medical treatment and nursing technical field, the composition that the present invention is provided has significant promotion wound healing effect, and haemostatic effect is good, and healing time significantly shortens, while the generation of scar can be prevented, realizes the curative effect of wound healing and preventing from scar, and security is good.
Description
Technical field
The invention belongs to medical treatment and nursing technical field, more particularly to a kind of composition for promoting the anti-scar of wound healing and its
Preparation.
Background technology
All the time, whether burn, scald, performing the operation or other modes are injured, impaired skin soft tissue can not be complete
Complete voluntarily normal reparation, turns by fibrous tissue replacement reparation and then will produce local scar.The normal healing of wound is mainly pressed
Carried out according to inflammation phase, granulation stage of development (or proliferative phase) and scar formation stages these three successive stages.Scar is main
Including following several：1. epidermis no concave-convex is the calm scars of the dark brown change of color of the leather purplish-black；2. epidermis is concavo-convex and purple
The color spot trace of black tea color change；3. epidermis high convex hard and purple color change " pimple " scar；4. the spontaneous convex heavily fortified point high of epidermis
Hard purple color change, settled tower dermatoma of unlimited development etc..Scar is a kind of normal physiology during wound normal healing
Reaction, it is more difficult to avoid, scar can cause the pole of body skin unsightly once being formed, and pain is brought to patient, cause to regret.
At present, with promoting the composition of wound healing effect numerous, such as cell factor, natural plant extracts, Chinese medicine are lived
Property composition, polymer etc..By the combination of Multiple components, while wound healing is promoted, tend to reduce the production of scar,
But the inhibition for scar is still not ideal enough, it is impossible to realize the anti-scar of wound healing (preventing from scar or without obvious scar wheel
It is wide) effect.
Chinese patent application CN 103191163 discloses a kind of skin wound repair medicine composition and its gel, medicine
Compositions are made up of Policresulen and asiaticoside, and pharmaceutical composition gel includes shitosan, Sodium Hyaluronate, gathers
Cresols sulphur aldehyde, asiaticoside, pharmaceutical composition gel can still form larger face after remarkably promoting wound healing, but healing
Long-pending scar.
Chinese patent application CN 104257682 discloses a kind of surface of a wound maintenance composition, by trehalose, carboxymethyl cellulose
Plain sodium composition, with preferable wound healing effect, also has certain inhibition to the formation of scar, but scar suppresses effect
Fruit still has much room for improvement.
The clinical treatment for removing scar has a lot, such as operation, radiotherapy, laser, injection of hormone and drug therapy,
But generally offer limited effectiveness, and there is the shortcomings of complex operation, larger side effect, high recurrence rate, long term administration inconvenience.It is various
Scar of dispelling product emerges in an endless stream, scar of dispelling paster, scar of dispelling medicine, scar of dispelling repair materials etc..The function that scar of dispelling product is acted on scar
Limited, scar of dispelling effect still has much room for improvement.There is no preferable treatment method at present can completely cure the scar for having been formed.
Therefore it provides a kind of composition that can prevent scar from generating while wound healing is promoted is significant.
The content of the invention
To solve problems of the prior art, inventor carries out other work based on natural plant extracts
The screening of property composition and compounding, unexpected discovery：Onion bulb stem extract, Gotu Kola P.E, beta glucan, shell is few
Sugar and catechin compound the composition for obtaining by a certain percentage has significant promotion wound healing effect, while scar can be prevented
Generation, realize the curative effect of wound healing and preventing from scar, security is good, and the wound healing skin surface after use is smooth flat
Whole, skin elasticity is approached with periphery normal skin.Based on above-mentioned discovery, so as to complete the present invention.
The purpose of the present invention will be further described in detail below reflect and description.
The present invention provides a kind of composition of the promotion anti-scar of wound healing, including following component and its parts by weight：Ocean
5~10 parts of green onion bulb extract, 0.1~3 part of Gotu Kola P.E, 1~10 part of beta glucan, 15~25 parts of chitosan oligosaccharide and catechu
5~10 parts of element.
Using above-mentioned technical proposal, by onion bulb stem extract, Gotu Kola P.E, beta glucan, chitosan oligosaccharide and youngster
The collective effect of theine, can realize the quick healing of wound, while the generation of scar can be prevented, realize wound healing without staying scar
The curative effect of trace.
Onion bulb stem extract has functions that anti-inflammatory, antibacterial, can suppress fibroblastic increment, reduce connective tissue
Synthesis.Gotu Kola P.E has functions that anti-oxidant, promotion wound healing, can activate epithelial cell, promotes normal granulation
Organize the formation of, suppress fibroblastic propagation, there is certain suppression and retarding action to chaotic scar tissue propagation.
The polysaccharide that beta glucan is formed by D-Glucose monomer by the bond of glycosidic bond, special molecular structure can specificity
The immunocytes such as lymphocyte, macrophage and the B cell of body are activated, so as to strengthen body's immunity, is referred to as " exempting from
Epidemic disease polysaccharide "；Beta glucan also has activation to distinctive immunocyte-langhans' cells in skin, makes langhans' cells
Secretion cytokine profiles, can effectively repair damaged skin cell, increase the power of regeneration of damaged skin cell, improve skin
It is aging.Chitosan oligosaccharide is the oligosaccharide product through a kind of degree of polymerization for obtaining of degraded between 2~20 by shitosan, molecular weight≤
3200Da, water-soluble preferable, bioactivity is high, it is easy to absorb；Chitosan oligosaccharide can promote migration of fibroblast cells and propagation, secretion
A large amount of collagenous fibres, constitute granulation tissue and fill up tissue defect with the collective effect such as new capillary vessel, promote wound healing, also
The release of inflammatory cytokine can be adjusted, anti-inflammatory reduces non-specific damage factor, and preferred degree of polymerization is 6~12.Catechin
(catechin) it is topmost composition in millet paste, in bitter taste, is obtained by being extracted from tealeaves, with the cardiovascular disease of preventing and treating
Various functions such as disease, obesity controlling, pre- anti-cancer, can remove free radical, be commonly used for antioxidant, in dyestuff and tanning industry
Also wide application is obtained.
Preferably, the composition of the described promotion anti-scar of wound healing, including following component and its parts by weight：Onion
6~9 parts of bulb extract, 1~3 part of Gotu Kola P.E, 2~8 parts of beta glucan, 16~22 parts of chitosan oligosaccharide and catechin 6~9
Part.
Preferably, the composition of the described promotion anti-scar of wound healing, including following component and its parts by weight：Onion
8 parts of 8 parts of bulb extract, 2 parts of Gotu Kola P.E, 6 parts of beta glucan, 18 parts of chitosan oligosaccharide and catechin.
It is highly preferred that the beta glucan is yeast beta-dextran.
Correspondingly, the present invention also provides the preparation method of the composition of the described promotion anti-scar of wound healing, including such as
Lower step：Onion bulb stem extract, Gotu Kola P.E, beta glucan, chitosan oligosaccharide and catechin are weighed, is mixed, obtained final product.
Additionally, the present invention also provide it is a kind of promote the anti-scar of wound healing composite preparation, including following component and its
Parts by weight：30~80 parts of 20~70 parts of composition any one of Claims 1-4 and auxiliary material.
The preparations such as gel, paste are made by promoting the composition of the anti-scar of wound healing, beneficial to the work(of active ingredient
Effect is played and stabilization is preserved, and improves ease of use.In present composition gel system, beta glucan and chitosan oligosaccharide
In swelling state, to catechin isoreactivity into wrapping up, extensibility is good and with certain viscosity, and being attached to wound surface can
Protective layer is formed, while the diffusate of absorbable wound surface, moisturizing and good permeability.
Preferably, the composite preparation of the described promotion anti-scar of wound healing, including following component and its parts by weight：
0.5~5 part of described 25~50 parts of composition, Carbomer or Hydroxypropyl methylcellulose, 0.5~2 part of propane diols, 1~4 part of glycerine and
30~60 parts of water；The preparation is gel.
Preferably, the composite preparation of the described promotion anti-scar of wound healing, including following component and its parts by weight：
54 parts of described 40 parts of composition, 3 parts of Carbomer, 1 part of propane diols, 2 parts of glycerine and water.
Preferably, the composite preparation of the described promotion anti-scar of wound healing, its preparation method comprises the following steps：
S1 weighs onion bulb stem extract, Gotu Kola P.E, beta glucan, chitosan oligosaccharide and catechin, mixes, and obtains group
Compound；
S2 weighs Carbomer or Hydroxypropyl methylcellulose, propane diols and glycerine, adds water, is carried out in 45~60 DEG C swelling, obtains
To the matrix after swelling；
S3 to it is described it is swelling after matrix in add the composition, mix, cooling, obtain final product.
Compared with prior art, beneficial effects of the present invention include：Extracted by by onion bulb stem extract, centella
Thing, beta glucan, chitosan oligosaccharide and catechin are compounded by a certain percentage, and the composition for obtaining plays synergy, with significant
Promote wound healing effect, haemostatic effect is good, and healing time significantly shortens, while the generation of scar can be prevented, realizes that wound is healed
Close and the curative effect of preventing from scar, security is good.Additionally, present invention also offers the composition system for promoting the anti-scar of wound healing
Agent, moisturizing and good permeability, efficacy exertion and stabilization beneficial to active ingredient are preserved, and improve ease of use, after use
Wound healing skin surface it is smooth, skin elasticity and periphery normal skin are approached.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail.
In the present invention, involved component and raw material is conventional commercial product, or can be by the ordinary skill in the art
Means are obtained.Such as：Onion bulb stem extract is purchased from Hong Kong advanced technology Industrial Co., Ltd, and No. CAS is 8054-39-5；Accumulated snow
Careless extract is purchased from Guilin Laiyin Biotechnology Co., Ltd., and No. CAS is 84696-21-9.
Embodiment one promotes the composition of the anti-scar of wound healing
Promote the composition of the anti-scar of wound healing, in terms of parts by weight, including following component：Onion bulb stem extract 8
Part, 2 parts of Gotu Kola P.E, 6 parts of yeast beta-dextran, 18 parts of chitosan oligosaccharide and 8 parts of catechin.
Its preparation method comprises the following steps：Weigh onion bulb stem extract, Gotu Kola P.E, yeast beta-dextran,
Chitosan oligosaccharide and catechin, mix, and obtain final product.
Embodiment two promotes the composition of the anti-scar of wound healing
Promote the composition of the anti-scar of wound healing, in terms of parts by weight, including following component：Onion bulb stem extract 6
Part, 3 parts of Gotu Kola P.E, 4 parts of yeast beta-dextran, 20 parts of chitosan oligosaccharide and 6 parts of catechin.
Its preparation method comprises the following steps：Weigh onion bulb stem extract, Gotu Kola P.E, yeast beta-dextran,
Chitosan oligosaccharide and catechin, mix, and obtain final product.
Embodiment three promotes the composition of the anti-scar of wound healing
Promote the composition of the anti-scar of wound healing, in terms of parts by weight, including following component：Onion bulb stem extract 9
Part, 1 part of Gotu Kola P.E, 2 parts of yeast beta-dextran, 22 parts of chitosan oligosaccharide and 9 parts of catechin.
Its preparation method comprises the following steps：Weigh onion bulb stem extract, Gotu Kola P.E, yeast beta-dextran,
Chitosan oligosaccharide and catechin, mix, and obtain final product.
Example IV promotes the composition gels agent of the anti-scar of wound healing
Promote the composition gels agent of the anti-scar of wound healing, in terms of parts by weight, including following component：Embodiment one
54 parts of 40 parts of composition, 3 parts of Carbomer, 1 part of propane diols, 2 parts of glycerine and water.
Its preparation method comprises the following steps：
S1 weighs composition obtained in embodiment one；
S2 weighs Carbomer, propane diols and glycerine, adds water, carried out in 55 DEG C it is swelling, obtain it is swelling after matrix；
S3 to it is described it is swelling after matrix in add the composition, mix, cooling, obtain final product.
Embodiment five promotes the composition gels agent of the anti-scar of wound healing
Promote the composition gels agent of the anti-scar of wound healing, in terms of parts by weight, including following component：Embodiment one
54 parts of 40 parts of composition, 3 parts of Hydroxypropyl methylcellulose, 1.5 parts of propane diols, 1.5 parts of glycerine and water.
Its preparation method comprises the following steps：
S1 weighs composition obtained in embodiment one；
S2 weighs Hydroxypropyl methylcellulose, propane diols and glycerine, adds water, carried out in 55 DEG C it is swelling, obtain it is swelling after base
Matter；
S3 to it is described it is swelling after matrix in add the composition, mix, cooling, obtain final product.
Embodiment six promotes the composition gels agent of the anti-scar of wound healing
Promote the composition gels agent of the anti-scar of wound healing, in terms of parts by weight, including following component：Embodiment two
48 parts of 35 parts of composition, 2 parts of Carbomer, 2 parts of propane diols, 1 part of glycerine and water.
Its preparation method comprises the following steps：
S1 weighs composition obtained in embodiment two；
S2 weighs Carbomer, propane diols and glycerine, adds water, carried out in 55 DEG C it is swelling, obtain it is swelling after matrix；
S3 to it is described it is swelling after matrix in add the composition, mix, cooling, obtain final product.
Comparative example 1
Composition, in terms of parts by weight, including following component：8 parts of onion bulb stem extract, 2 parts of Gotu Kola P.E, ferment
8 parts of 24 parts of female beta glucan and catechin.
Composition gels agent, in terms of parts by weight, including following component：40 parts of composition, 3 parts of Carbomer, propane diols 1
54 parts of part, 2 parts of glycerine and water.
Comparative example 1 is with the difference of example IV：Chitosan oligosaccharide is free of in composition, the number of yeast beta-dextran increases
Plus.
Preparation method：Same example IV.
Comparative example 2
Composition, in terms of parts by weight, including following component：8 parts of onion bulb stem extract, 2 parts of Gotu Kola P.E, shell
8 parts of 24 parts of oligosaccharides and catechin.
Composition gels agent, in terms of parts by weight, including following component：40 parts of composition, 3 parts of Carbomer, propane diols 1
54 parts of part, 2 parts of glycerine and water.
Comparative example 2 is with the difference of example IV：Yeast beta-dextran is free of in composition, the number of chitosan oligosaccharide increases
Plus.
Preparation method：Same example IV.
Comparative example 3
Composition, in terms of parts by weight, including following component：8 parts of onion bulb stem extract, 2 parts of Gotu Kola P.E, ferment
18 parts of 6 parts of female beta glucan and chitosan oligosaccharide.
Composition gels agent, in terms of parts by weight, including following component：40 parts of composition, 3 parts of Carbomer, propane diols 1
54 parts of part, 2 parts of glycerine and water.
Comparative example 3 is with the difference of example IV：Catechin is free of in composition.
Preparation method：Same example IV.
Comparative example 4
Composition, in terms of parts by weight, including following component：8 parts of onion bulb stem extract, 2 parts of Gotu Kola P.E, ferment
8 parts of 6 parts of female beta glucan, 18 parts of chitosan oligosaccharide and allantoin.
Composition gels agent, in terms of parts by weight, including following component：40 parts of composition, 3 parts of Carbomer, propane diols 1
54 parts of part, 2 parts of glycerine and water.
Comparative example 4 is with the difference of example IV：Catechin is free of in composition, containing allantoin.
Preparation method：Same example IV.
The Skin sensitization of test example one
Take healthy Hartley cavys 48 (purchased from Guangdong Medical Lab Animal Center), 270 ± 20g of body weight, random point
It is 8 groups, every group 6, male and female half and half, test group 1-3：The composition gels agent of example IV to embodiment six, examination are smeared respectively
Test a group 4-7：The composition gels agent of comparative example 1 to comparative example 4, positive controls are smeared respectively：Smear 2,4-dinitro-chlorine generation
Benzene.According to GB/T 16886.10-2005《BiologicalEvaluationofMedicalDevice》Evaluation is tested and is observed, as a result：Test group 1-
7 scoring is 0, and sensitization of skin reaction is negative, and security is good；And there are the symptoms such as erythema in the cavy of positive controls,
Sensitization of skin reaction is positive.Therefore, the security of present composition gel is good.
The skin wound healing of test example two is tested
Healthy SD rat 54 (purchased from Guangdong Medical Lab Animal Center) is taken, 200 ± 20g of body weight is randomly divided into 9
Group, every group 6, male and female half and half.Rat is anaesthetized using the ketalar of intraperitoneal injection 1%, treats that rat is in anesthesia
After state, in rat back vertebra side, hair is cut off, length and width 3cm × 3cm, the bar shaped of depth 0.2cm are cut with the scalpel of sterilization
The edge of a knife, test group 1-3：The composition gels agent of example IV to embodiment six, test group 4-7 are smeared respectively：It is right to smear respectively
Ratio 1 to comparative example 4 composition gels agent, positive controls：Smear skin wound induction gel (Taiyuan brocade ripple biological medicine
Science and Technology Ltd.), catechin group：Smear catechin, blank control group：Do not smeared.The observation rat wound bleeding time,
Treat that blood overflows beginning timing naturally, blot outflow blood with clean filter paper every 30s, it is to avoid filter paper contacts skin, until going out
The blood time stops naturally, records the time, as a result as shown in table 1.Smear 2 times daily, observe wound healing situation, use image
J softwares carry out image procossing, calculate wound healing rate, wound healing rate=(original wound area-non-healing of wound area)/original
Beginning wound area, as a result as shown in table 2.
The average bleeding time of the different group rats of table 1
As known from Table 1, the composite preparation (test group 1-3) that the present invention is provided has good haemostatic effect, hemostasis effect
Fruit is substantially better than positive controls and blank control group.Test group 6 (containing chitosan oligosaccharide and yeast beta-dextran, without catechin)
Bleeding time is most short, test group 4 and test group 5 prolonged bleeding time when chitosan oligosaccharide and yeast beta-dextran is lacked respectively, says
Exist while bright chitosan oligosaccharide and yeast beta-dextran significant for improving haemostatic effect；During the bleeding of catechin group
Between be considerably longer than test group 1-7, it is and close with blank control group, illustrate that catechin does not almost have haemostatic effect；Test group 7 (contains
Chitosan oligosaccharide and yeast beta-dextran, containing Sodium Hyaluronate, without catechin) also there is preferable haemostatic effect.
Average lesion healing rate/the % of the different group rats of table 2
Test group 1 realized that wound healed completely at the 11st day, and healing rate reaches 100%, decrustation, test group 2 and 3
Realized that wound healed completely at the 12nd day, illustrating the composite preparation (test group 1-3) of present invention offer can remarkably promote wound
Healing, promotes healing effect to be better than positive controls.Test group 6 and 7 also achieved wound and heals completely at the 12nd day, and tested
Group 4,5 and positive controls realized that wound healed completely at the 13rd day, illustrated to be deposited while chitosan oligosaccharide and yeast beta-dextran
For promoting wound healing effect significant；Catechin group and blank control group realized that wound was complete at the 15th day
Healing.
Each test group and positive controls healed completely to wound carry out scar situation observation, using ArcGIS Grid Methods
Scar area is calculated, as a result as shown in table 3.
Average scar area after the different group rat wound healings of table 3
After the wound of test group 1-3 heals completely, without scar profile, skin surface is smooth, skin elasticity and periphery
Normal skin is approached, and illustrates the composition gels agent for providing of the invention preventing from scar while wound healing is promoted, hence it is evident that excellent
In positive controls；And after the wound of test group 4-7 and positive controls heals completely, there is scar profile, part scar
Trace color of the leather is slightly dark, and elasticity is poor, wherein maximum with the scar area of test group 6, the scar area of test group 4 and test group 5 is bright
It is aobvious to be less than test group 6 and test group 7, illustrate that generation of the catechin for preventing or reducing scar serves important function, and it is same
The allantoin that sample has anti-oxidation function then cannot play obvious effect to reducing scar.
In sum, the catechin in present composition gel there occurs with chitosan oligosaccharide and yeast beta-dextran and cooperate with
Effect, it is therefore prevented that the generation of scar, catechin plays an important role to anti-scar in wound healing process, may be with catechin
Cell regulatory function is relevant.
Above content is to combine specific preferred embodiment further description made for the present invention, it is impossible to assert
Specific implementation of the invention is confined to these explanations.For general technical staff of the technical field of the invention,
On the premise of not departing from present inventive concept, some simple deduction or replace can also be made, should be all considered as belonging to of the invention
Protection domain.
Claims (9)
1. it is a kind of promote the anti-scar of wound healing composition, it is characterised in that：Including following component and its parts by weight：Onion
5~10 parts of bulb extract, 0.1~3 part of Gotu Kola P.E, 1~10 part of beta glucan, 15~25 parts of chitosan oligosaccharide and catechin
5~10 parts.
2. it is according to claim 1 promote the anti-scar of wound healing composition, it is characterised in that：Including following component and
Its parts by weight：6~9 parts of onion bulb stem extract, 1~3 part of Gotu Kola P.E, 2~8 parts of beta glucan, chitosan oligosaccharide 16~
22 parts and 6~9 parts of catechin.
3. it is according to claim 2 promote the anti-scar of wound healing composition, it is characterised in that：Including following component and
Its parts by weight：8 parts of onion bulb stem extract, 2 parts of Gotu Kola P.E, 6 parts of beta glucan, 18 parts of chitosan oligosaccharide and catechin 8
Part.
4. it is according to any one of claim 1 to 3 promote the anti-scar of wound healing composition, it is characterised in that：Institute
Beta glucan is stated for yeast beta-dextran.
5. the preparation method of the composition for promoting the anti-scar of wound healing according to any one of claim 1 to 4, it is special
Levy and be：Comprise the following steps：Onion bulb stem extract, Gotu Kola P.E, beta glucan, chitosan oligosaccharide and catechin are weighed,
Mix, obtain final product.
6. it is a kind of promote the anti-scar of wound healing composite preparation, it is characterised in that：Including following component and its parts by weight：
30~80 parts of 20~70 parts of composition any one of Claims 1-4 and auxiliary material.
7. it is according to claim 6 promote the anti-scar of wound healing composite preparation, it is characterised in that：Including such as the following group
Divide and its parts by weight：25~50 parts of composition, Carbomer or Hydroxypropyl methylcellulose any one of Claims 1-4
30~60 parts of 0.5~5 part, 0.5~2 part of propane diols, 1~4 part of glycerine and water；The preparation is gel.
8. it is according to claim 7 promote the anti-scar of wound healing composite preparation, it is characterised in that：Including such as the following group
Divide and its parts by weight：40 parts of composition any one of Claims 1-4,3 parts of Carbomer, 1 part of propane diols, glycerine 2
54 parts of part and water.
9. it is according to claim 7 promote the anti-scar of wound healing composite preparation, it is characterised in that：Its preparation method
Comprise the following steps：
S1 weighs onion bulb stem extract, Gotu Kola P.E, beta glucan, chitosan oligosaccharide and catechin, mixes, and is combined
Thing；
S2 weighs Carbomer or Hydroxypropyl methylcellulose, propane diols and glycerine, adds water, is carried out in 45~60 DEG C swelling, obtains molten
Matrix after swollen；
S3 to it is described it is swelling after matrix in add the composition, mix, cooling, obtain final product.
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| CN109675091A (en) * | 2019-01-26 | 2019-04-26 | 湖南博隽生物医药有限公司 | A kind of biological dressing and preparation method thereof for eliminating scar |
| CN111358940A (en) * | 2020-05-14 | 2020-07-03 | 深圳爱思得美容科技有限公司 | Application of scar removing, preventing and controlling combined liquid |
| CN115501246A (en) * | 2022-10-31 | 2022-12-23 | 湖南天根乐微君科技有限公司 | Composition and preparation method and application thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107583101A (en) * | 2017-09-27 | 2018-01-16 | 广州润虹医药科技股份有限公司 | A kind of biological membrane preparations for promoting wound healing and preparation method thereof |
| CN108578540A (en) * | 2018-06-05 | 2018-09-28 | 深圳市旷逸生物科技有限公司 | A kind of biologic formulation and preparation method thereof for inhibiting scar and promoting wound healing |
| CN109675091A (en) * | 2019-01-26 | 2019-04-26 | 湖南博隽生物医药有限公司 | A kind of biological dressing and preparation method thereof for eliminating scar |
| CN111358940A (en) * | 2020-05-14 | 2020-07-03 | 深圳爱思得美容科技有限公司 | Application of scar removing, preventing and controlling combined liquid |
| CN115501246A (en) * | 2022-10-31 | 2022-12-23 | 湖南天根乐微君科技有限公司 | Composition and preparation method and application thereof |
| CN115501246B (en) * | 2022-10-31 | 2023-08-08 | 湖南天根乐微君科技有限公司 | Composition capable of effectively repairing, desalting and removing scars and preparation method and application thereof |
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