CN106727115B - A kind of face cream and preparation method thereof for hyperplastic scar reparation - Google Patents
A kind of face cream and preparation method thereof for hyperplastic scar reparation Download PDFInfo
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- CN106727115B CN106727115B CN201611143271.8A CN201611143271A CN106727115B CN 106727115 B CN106727115 B CN 106727115B CN 201611143271 A CN201611143271 A CN 201611143271A CN 106727115 B CN106727115 B CN 106727115B
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- face cream
- hyperplastic scar
- scar
- catechin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Abstract
The present invention provides a kind of face cream for hyperplastic scar reparation, including following component and its parts by weight: 0.1~2 part of onion bulb stem extract, 0.01~0.5 part of Gotu Kola P.E, 0.1~2 part of beta glucan, 1~5 part of catechin, 0.0002~0.002 part of rhIL-12(p70), 1~5 part of saualane, 1~3 part of wheat-germ oil, 2~4 parts of cetearyl glucoside, 1~5 part of isopropyl myristate, 1~5 part of ethylhexyl palmitate, 0.5~2 part of octyl methoxycinnamate, 1~5 part of glycerol, 0.5~2 part of cetostearyl alcohol, 0.5~2 part and 70~85 parts of water of propylene glycol.The invention belongs to cosmetic technical field, face cream safety provided by the invention is good, without side-effects, rapid-action, has good repairing effect to hyperplastic scar, whitening effect is good, is easy to be accepted by patients, have a vast market foreground.
Description
Technical field
The invention belongs to cosmetic technical field more particularly to a kind of face cream and its system for hyperplastic scar reparation
Preparation Method.
Background technique
Scar formation is the normal outcome that body is healed by post-trauma wound, if timely before forming scar after wound
Effective prevention is carried out, then is expected to avoid the formation of scar.Scar is once being formed, it is difficult to cure completely, treatment difficulty is greater than prevention
Difficulty.Scar can be divided into abnormal scar and pathology scars, and pathology scars mainly include hyperplastic scar and keloid.II
Du or more burnt degree often will form hyperplastic scar, the main clinic symptoms of hyperplastic scar are that scar lesion is higher than week
Normal skin is enclosed, local matter is hard, thickens, and sufferings symptom is mainly shown as in early days, when environment temperature increases, wave occurs in patient mood
When moving or feeding pungent irritable food, cusalgia and scratchiness can aggravate, and cause somatopsychic disturbance to patient.
The treatment of hyperplastic scar is hang-up, and existing common treatment method includes pressure therapy, medicinal treatment and
Radiation therapy etc..Pressure therapy is uneven to rugged scar surface pressure and pressure sleeve and scar between rub and often lead
Scar surface ulceration is caused, in addition influences the reflux of vein due to pressurizeing for a long time when four limbs are applied, is caused acral swollen
The bad phenomenons such as swollen.Radiation therapy, be only applicable to the prevention and treatment of local fritter scar, although effect is preferable, somewhat expensive and
Side effect is larger.Drug used in medicinal treatment mainly includes steroids corticoid, silicone, and treatment cycle is longer,
There are certain side effect, the compliance of patient is poor.
Chinese patent application CN 103495155 discloses a kind of pad pasting for hyperplastic scar reparation, including successively glues
Back sheet, sticky polymer nitride layer and the separation layer connect, sticky polymer nitride layer include sticky polymer object, liposome permeation enhancers and dispel
Scar active component, scar of dispelling active component include gamma interferon, Va acid and Ve, pass through scar active component and the permeation enhancers etc. of dispelling
Collective effect, realizes preferable hyperplastic scar repairing effect, but there are the dosage of gamma interferon is larger, and prepared by pad pasting
The problem of complex process, is unfavorable for industrialization promotion.
The prior art also discloses the Chinese medicine composition of more treatment hyperplastic scar, as CN104547793 eliminates hyperplasia
A kind of Chinese medicine composition of Inhibiting proliferation scars of Chinese medicine composition and preparation method, the CN103800452 of scars and preparation
Method and a kind of drug for treating hyperplastic scar of purposes, CN105106878 and preparation method thereof, etc..
Therefore, it in the case where existing hyperplastic scar therapeutic modality and therapeutic agent are difficult to meet patient demand, mentions
For a kind for the treatment of and reparation safely and effectively used for cosmetic in hyperplastic scar, the compliance of patient can be significantly improved, is had
Significance and vast market prospect.
Summary of the invention
To solve problems of the prior art, inventor is unexpected by many multi-component screenings and compounding
Ground discovery: onion bulb stem extract, Gotu Kola P.E, beta glucan, catechin and rhIL-12(p70) are pressed one
Fixed ratio compounding, safety is good, without side-effects, rapid-action, has good repairing effect to hyperplastic scar, and further
It is made into safe and effective face cream, whitening effect is good, is easy to be accepted by patients, have a vast market foreground.Based on upper
Discovery is stated, thereby completing the present invention.
The purpose of the present invention will be further described in detail below reflect and description.
The present invention provides a kind of face cream for hyperplastic scar reparation, including following component and its parts by weight: ocean
0.1~2 part of green onion bulb extract, 0.01~0.5 part of Gotu Kola P.E, 0.1~2 part of beta glucan, 1~5 part of catechin, again
Group 0.0002~0.002 part of hIL-12,1~5 part of saualane, 1~3 part of wheat-germ oil, cetearyl Portugal
2~4 parts of glucosides, 1~5 part of isopropyl myristate, 1~5 part of ethylhexyl palmitate, octyl methoxycinnamate 0.5~2
Part, 1~5 part of glycerol, 0.5~2 part of cetostearyl alcohol, 0.5~2 part of propylene glycol and 70~85 parts of water.
By adopting the above technical scheme, pass through onion bulb stem extract, Gotu Kola P.E, beta glucan, catechin and again
The collective effect of group hIL-12, it is rapid-action, it is able to achieve effective reparation of hyperplastic scar, combining human interleukins
The dosage of element -12 is few, reduces costs, safely, effectively, whitening effect is good for face cream, is easy to be accepted by patients.
Onion bulb stem extract has effects that anti-inflammatory, antibacterial, can inhibit fibroblastic increment, reduce connective tissue
Synthesis.Gotu Kola P.E has effects that anti-oxidant, promotion wound healing, can activate epithelial cell, promote normal granulation
It organizes the formation of, inhibits fibroblastic proliferation, there is certain inhibition and retarding action to chaotic scar tissue proliferation.
Beta glucan is formed by polysaccharide by the bond of glycosidic bond for D-Glucose monomer, and special molecular structure can specificity
The immunocytes such as lymphocyte, macrophage and the B cell of body are activated to be referred to as " exempting to enhance body's immunity
Epidemic disease polysaccharide "；Beta glucan also has activation to immunocyte-langhans' cells distinctive in skin, makes langhans' cells
Cytokine profiles are secreted, damaged skin cell can be effectively repaired, increase the power of regeneration of damaged skin cell, improve skin
Aging.Catechin (catechin) is most important ingredient in millet paste, is in bitter taste, is obtained, had by extracting from tealeaves
The multiple functions such as prevention and cure of cardiovascular disease, obesity controlling, pre- anti-cancer, can remove free radical, be commonly used for antioxidant, contaminate
Material and tanning industry also obtain wide application.RhIL-12(p70) (rhIL-12) is by two Asias p40 and p35
The heterodimeric protein that unit is made up of multipair disulfide bond, can Transdermal absorption to corium and subcutaneous tissue, it is thin by bright Han Shi
Born of the same parents mediate the T lymphocyte that can activate corium, it is promoted to generate gamma interferon, and gamma interferon can inhibit fiber female thin
Born of the same parents' proliferation, inhibits proline hydroxylase required for collage synthesis, and collagen is prevented to generate, moreover it is possible to stimulate the secretion of clostridiopetidase A, promote
Into collagen hydro, the mRNA level in-site of fibroblast I, type III collagen is reduced, inhibits fibroblast secretion alkaline fiber female thin
The intracellular growth factor (bFGF), and then inhibit collage synthesis, and then inhibit collage synthesis, prevent scar hyperplasia.
Preferably, the face cream for hyperplastic scar reparation, including following component and its parts by weight: onion
0.5~1.5 part of bulb extract, 0.1~0.4 part of Gotu Kola P.E, 0.5~1.5 part of beta glucan, 2~4 parts of catechin,
0.0005~0.0015 part of rhIL-12(p70), 2~4 parts of saualane, 1~3 part of wheat-germ oil, cetearyl
2~4 parts of glucoside, 3~5 parts of isopropyl myristate, 2~4 parts of ethylhexyl palmitate, octyl methoxycinnamate 1~2
Part, 3~5 parts of glycerol, 1~2 part of cetostearyl alcohol, 0.5~2 part of propylene glycol and 70~80 parts of water.
It is highly preferred that the face cream for hyperplastic scar reparation, further includes 0.1~0.5 part of preservative.This hair
It is bright also to add a small amount of essence and/or pH adjusting agent according to actual needs.
It is highly preferred that the face cream for hyperplastic scar reparation, including following component and its parts by weight: ocean
1 part of green onion bulb extract, 0.2 part of Gotu Kola P.E, 1.2 parts of beta glucan, 3 parts of catechin, recombinant human interleukin-
120.0008 parts, 3 parts of saualane, 2 parts of wheat-germ oil, 3 parts of cetearyl glucoside, 4 parts of isopropyl myristate, palm
3 parts of sour ethylhexyl, 1 part of octyl methoxycinnamate, 4 parts of glycerol, 1.4 parts of cetostearyl alcohol, 1 part of propylene glycol, preservative 0.2
Part, 72 parts of water.
Preservative can be the conventional preservatives of this field, it is preferable that the preservative is antibacterial peptide.Antibacterial peptide is a kind of
Biologically active micromolecule polypeptide, molecular weight are made of 20~60 amino acid residues, have between 2000~7000
Broad spectrum antibiotic activity has very strong lethal effect to bacterium, and safety is good.More specifically, antibacterial peptide is house fly antibiotic peptide.
Preferably, the beta glucan is yeast beta-dextran.
Correspondingly, the present invention also provides the preparation methods of the face cream for hyperplastic scar reparation, including walk as follows
It is rapid:
S1 weigh saualane, wheat-germ oil, cetearyl glucoside, isopropyl myristate, palm acid ethyl oneself
Ester, octyl methoxycinnamate and cetostearyl alcohol are stirred and heated to 80~85 DEG C, obtain material A in first reactor,
It keeps the temperature spare；
S2 weighs glycerol, propylene glycol and water in second reactor, is stirred and heated to 80~85 DEG C, is slowly added to described
Material flow A stirs homogeneous, obtains material B；
The material B is cooled to 40~45 DEG C by S3, weighs and onion bulb stem extract, Gotu Kola P.E, β-is added
Glucan, catechin and rhIL-12(p70), stir evenly, cooling, obtain the skin care for hyperplastic scar reparation
Frost.
Preferably, the step S3 further includes the steps that weighing and antibacterial peptide is added.
Compared with prior art, the beneficial effect comprise that the present invention is by by onion bulb stem extract, centella
Extract, beta glucan, catechin and rhIL-12(p70) compound according to a certain percentage, and skin care is further made
Frost, safety is good, without side-effects, rapid-action, to hyperplastic scar have good repairing effect, whitening effect is good, be easy to by
Patient receives, and the dosage of rhIL-12(p70) is few, reduces costs.In addition, the preparation of face cream provided by the invention
Method is simple, and face cream quality obtained is stablized.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail.
In the present invention, related component and raw material are conventional commercial product, or can pass through the ordinary skill in the art
Means obtain.Such as: onion bulb stem extract is purchased from Hong Kong advanced technology Industrial Co., Ltd, and No. CAS is 8054-39-5；Accumulated snow
Careless extract is purchased from Guilin Laiyin Biotechnology Co., Ltd., and No. CAS is 84696-21-9.
Embodiment one is used for the face cream of hyperplastic scar reparation
For the face cream of hyperplastic scar reparation, including following component and its parts by weight: onion bulb stem extract 1
Part, 0.2 part of Gotu Kola P.E, 1.2 parts of beta glucan, 3 parts of catechin, 0.0008 part of rhIL-12(p70), angle
3 parts of shark alkane, 2 parts of wheat-germ oil, 3 parts of cetearyl glucoside, 4 parts of isopropyl myristate, ethylhexyl palmitate 3
Part, 1 part of octyl methoxycinnamate, 4 parts of glycerol, 1.4 parts of cetostearyl alcohol, 1 part of propylene glycol, 0.2 part of house fly antibiotic peptide, water 72
Part.
Preparation method includes the following steps:
S1 weigh saualane, wheat-germ oil, cetearyl glucoside, isopropyl myristate, palm acid ethyl oneself
Ester, octyl methoxycinnamate and cetostearyl alcohol are stirred and heated to 82 DEG C in first reactor, obtain material A, heat preservation
It is spare；
S2 weighs glycerol, propylene glycol and water in second reactor, is stirred and heated to 82 DEG C, is slowly added to the logistics
A stirs homogeneous, obtains material B；
The material B is cooled to 42 DEG C by S3, and it is poly- to weigh and be added onion bulb stem extract, Gotu Kola P.E, β-Portugal
Sugar, catechin, rhIL-12(p70) and house fly antibiotic peptide, stir evenly, cooling, obtain repairing for hyperplastic scar
Multiple face cream.
Embodiment two is used for the face cream of hyperplastic scar reparation
For the face cream of hyperplastic scar reparation, including following component and its parts by weight: onion bulb stem extract 1.5
Part, 0.4 part of Gotu Kola P.E, 1.0 parts of beta glucan, 2.5 parts of catechin, 0.001 part of rhIL-12(p70), angle
4 parts of shark alkane, 1 part of wheat-germ oil, 3 parts of cetearyl glucoside, 2 parts of isopropyl myristate, ethylhexyl palmitate 2.5
Part, 1.4 parts of octyl methoxycinnamate, 3 parts of glycerol, 2 parts of cetostearyl alcohol, 0.5 part of propylene glycol, 0.2 part of house fly antibiotic peptide, water
75 parts.
Preparation method includes the following steps:
S1 weigh saualane, wheat-germ oil, cetearyl glucoside, isopropyl myristate, palm acid ethyl oneself
Ester, octyl methoxycinnamate and cetostearyl alcohol are stirred and heated to 80 DEG C in first reactor, obtain material A, heat preservation
It is spare；
S2 weighs glycerol, propylene glycol and water in second reactor, is stirred and heated to 80 DEG C, is slowly added to the logistics
A stirs homogeneous, obtains material B；
The material B is cooled to 40 DEG C by S3, and it is poly- to weigh and be added onion bulb stem extract, Gotu Kola P.E, β-Portugal
Sugar, catechin, rhIL-12(p70) and house fly antibiotic peptide, stir evenly, cooling, obtain repairing for hyperplastic scar
Multiple face cream.
Embodiment three is used for the face cream of hyperplastic scar reparation
For the face cream of hyperplastic scar reparation, including following component and its parts by weight: onion bulb stem extract 0.5
Part, 0.2 part of Gotu Kola P.E, 1.5 parts of beta glucan, 4 parts of catechin, 0.0005 part of rhIL-12(p70), angle
2 parts of shark alkane, 2.6 parts of wheat-germ oil, 2 parts of cetearyl glucoside, 3 parts of isopropyl myristate, ethylhexyl palmitate 4
Part, 2 parts of octyl methoxycinnamate, 5 parts of glycerol, 1 part of cetostearyl alcohol, 2 parts of propylene glycol, 0.2 part of house fly antibiotic peptide, water 70
Part.
Preparation method includes the following steps:
S1 weigh saualane, wheat-germ oil, cetearyl glucoside, isopropyl myristate, palm acid ethyl oneself
Ester, octyl methoxycinnamate and cetostearyl alcohol are stirred and heated to 82 DEG C in first reactor, obtain material A, heat preservation
It is spare；
S2 weighs glycerol, propylene glycol and water in second reactor, is stirred and heated to 82 DEG C, is slowly added to the logistics
A stirs homogeneous, obtains material B；
The material B is cooled to 42 DEG C by S3, and it is poly- to weigh and be added onion bulb stem extract, Gotu Kola P.E, β-Portugal
Sugar, catechin, rhIL-12(p70) and house fly antibiotic peptide, stir evenly, cooling, obtain repairing for hyperplastic scar
Multiple face cream.
Comparative example 1
Face cream includes following component and its parts by weight: 1 part of onion bulb stem extract, 0.2 part of Gotu Kola P.E, β-
1.2 parts of glucan, 3 parts of catechin, 0.0008 part of gamma interferon, 3 parts of saualane, 2 parts of wheat-germ oil, cetearyl Portugal
3 parts of glucosides, 4 parts of isopropyl myristate, 3 parts of ethylhexyl palmitate, 1 part of octyl methoxycinnamate, 4 parts of glycerol, spermaceti
1.4 parts of stearyl alcohol, 1 part of propylene glycol, 0.2 part of house fly antibiotic peptide, 72 parts of water.
Preparation method is the same as embodiment one.
Comparative example 1 and the difference of embodiment one are: being free of rhIL-12(p70), γ-interference containing equivalent
Element.
Comparative example 2
Face cream includes following component and its parts by weight: 1 part of onion bulb stem extract, 0.2 part of Gotu Kola P.E, β-
1.2 parts of glucan, 3 parts of catechin, 3 parts of saualane, 2 parts of wheat-germ oil, 3 parts of cetearyl glucoside, myristic acid are different
4 parts of propyl ester, 3 parts of ethylhexyl palmitate, 1 part of octyl methoxycinnamate, 4 parts of glycerol, 1.4 parts of cetostearyl alcohol, propylene glycol 1
Part, 0.2 part of house fly antibiotic peptide, 72 parts of water.
Preparation method is the same as embodiment one.
Comparative example 2 and the difference of embodiment one are: being free of rhIL-12(p70).
Comparative example 3
Face cream includes following component and its parts by weight: 1 part of onion bulb stem extract, 0.2 part of Gotu Kola P.E, β-
1.2 parts of glucan, 3 parts of allantoin, 0.0008 part of rhIL-12(p70), 3 parts of saualane, 2 parts of wheat-germ oil, whale
It is 3 parts of wax stearyl glucoside, 4 parts of isopropyl myristate, 3 parts of ethylhexyl palmitate, 1 part of octyl methoxycinnamate, sweet
Oily 4 parts, 1.4 parts of cetostearyl alcohol, 1 part of propylene glycol, 0.2 part of house fly antibiotic peptide, 72 parts of water.
Preparation method is the same as embodiment one.
Comparative example 3 and the difference of embodiment one are: being free of catechin, the allantoin containing equivalent.
Comparative example 4
Face cream includes following component and its parts by weight: 1 part of onion bulb stem extract, 0.2 part of Gotu Kola P.E, β-
1.2 parts of glucan, 0.0028 part of rhIL-12(p70), 3 parts of saualane, 2 parts of wheat-germ oil, cetearyl Portugal
3 parts of glucosides, 4 parts of isopropyl myristate, 3 parts of ethylhexyl palmitate, 1 part of octyl methoxycinnamate, 4 parts of glycerol, spermaceti
1.4 parts of stearyl alcohol, 1 part of propylene glycol, 0.2 part of house fly antibiotic peptide, 72 parts of water.
Preparation method is the same as embodiment one.
Comparative example 4 and the difference of embodiment one are: being free of catechin, rhIL-12(p70) increases to
0.0028 part.
One safety testing of test example
It takes healthy Hartley cavy 48 (purchased from Guangdong Medical Lab Animal Center), 270 ± 20g of weight, random point
It is 8 groups, every group 6, test group 1-3: half male and half female smears face cream of the embodiment one to embodiment three, test group 4- respectively
7: smearing face cream of the comparative example 1 to comparative example 4 respectively, positive controls: smearing 2,4-dinitro-chloro-benzenes.According to GB/
T16886.10-2005 " BiologicalEvaluationofMedicalDevice " is tested and observed evaluation, as a result: the scoring of test group 1-7 is
0, sensitization of skin reaction is negative, and safety is good；And there is the symptoms such as erythema, sensitization of skin reaction in the cavy of positive controls
It is positive.As it can be seen that provided by the present invention for hyperplastic scar reparation face cream without sensitization, safety is good.
In addition, referring to the Ministry of Public Health issue 2015 editions " cosmetics health specifications " in " human skin patch " correlation
It is required that testing with measuring method the face cream of the embodiment of the present invention one to embodiment 3, comparative example 1 to comparative example 4, respectively
0h, 6h, 12h, for 24 hours, 48h observe dermoreaction, the experimental result of all trial volunteers is negative findings, does not occur skin
Skin adverse reaction.Nonirritant provided by the present invention for the face cream of hyperplastic scar reparation, safety is good.
Therapeutic test of the face cream provided by the invention of test example two to new zealand rabbit hyperplastic scar
Healthy new zealand rabbit 48 (purchased from Guangdong Medical Lab Animal Center) is taken, female, weight is in 2.6~3.0kg
Between.Entitled " a kind of foundation of hyperplastic scar animal model " of " Chinese skin cypridology magazine " is published in referring to Zhang Tong etc.
Paper in method construct to obtain hyperplastic scar animal model, the average scar index of 3 months after operation new zealand rabbit is
1.21 ± 0.14, it is randomly divided into 8 groups and starts to carry out therapeutic test, respectively test group 1-6 (smears embodiment one respectively, implements
The face cream of example two, comparative example 1, comparative example 2, comparative example 3, comparative example 4), positive controls (smear commercially available lavender scar
Frost), catechin group (smear catechin), model group (smearing water), every group 6, each group does not have statistical difference before the treatment,
Respectively to before each group treatment, treatment two weeks, treatment 1 month, treat 2 months scar indexes and measure calculating, as a result such as
Shown in table 1.Scar index=(skin highest thickness-normal adjacent tissue skin thickness at rabbit ear scar)/normal adjacent tissue
Skin thickness, thickness measure operate B-mode ultrasonic apparatus (EUB-450) by professional person and carry out.
The scar index that 1 face cream of table treats new zealand rabbit hyperplastic scar
| Group | Before treatment | Treat two weeks | Treatment 1 month | Treatment 2 months |
| Test group 1 | 1.22±0.15 | 0.86±0.09**△△ | 0.58±0.07**△△ | 0.35±0.05**△△ |
| Test group 2 | 1.20±0.14 | 0.90±0.11**△△ | 0.65±0.08**△△ | 0.44±0.07**△△ |
| Test group 3 | 1.21±0.12 | 1.05±0.10** | 0.92±0.08** | 0.76±0.07** |
| Test group 4 | 1.20±0.15 | 1.12±0.11** | 1.02±0.09** | 0.87±0.06** |
| Test group 5 | 1.22±0.12 | 1.03±0.12** | 0.91±0.07** | 0.71±0.07**△ |
| Test group 6 | 1.22±0.14 | 0.96±0.10**△ | 0.83±0.06**△ | 0.62±0.05**△△ |
| Positive controls | 1.21±0.15 | 1.10±0.11** | 1.01±0.10** | 0.85±0.08** |
| Catechin group | 1.20±0.12 | 1.61±0.22 | 1.93±0.31 | 1.96±0.36 |
| Model group | 1.19±0.13 | 1.68±0.24 | 2.05±0.35 | 2.03±0.42 |
Note: compared with model group:**P < 0.01；Compared with positive controls,△P < 0.05,△△P < 0.01.
As known from Table 1, face cream (test group 1 and test group 2) provided by the invention can significantly reduce scar index, hence it is evident that
Lower than positive controls (P < 0.01), there is significant repairing effect to hyperplastic scar, and rapid-action, treatment two weeks is
It can be obtained substantive improvement, the scar index for the treatment of 2 months is down to 0.35；Test group 3 (is free of recombinant human interleukin-
12, the gamma interferon containing equivalent) scar index, but the no difference of science of statistics compared with positive controls can be reduced；Test group 4 is (no
Containing rhIL-12(p70)) scar index, but the no difference of science of statistics compared with positive controls can be reduced；Test group 5
(be free of catechin, the allantoin containing equivalent) can reduce scar index, treatment two weeks and after treating 1 month with positive controls
Compared to no difference of science of statistics, treatment had statistical difference (P < 0.05) after 2 months compared with positive controls；Test group 6 is (no
Containing catechin, rhIL-12(p70) increases) can reduce scar index, treatment two weeks and after treating 1 month with the positive
For control group compared to having statistical difference (P < 0.05), treatment had statistical difference (P < after 2 months compared with positive controls
0.01), but scar index is apparently higher than test group 1 and test group 2；Catechin group and model group are substantially suitable, and no statistics is poor
It is different.
The organoleptic conditions such as the scar tissue quality during observation treatment, as a result: test group 1 and test group 2 treat two weeks
Occurs the softening of scar afterwards, red starts to shoal, and after treatment 2 months, scar obviously softens, and whiteness obviously increases, and surface becomes
Obtain smooth, the close normal skin closed on of surface flatness；And test group 3-6, positive controls just occur after treatment 1 month
The softening of scar, red shoal.
By comparison, it can be found that rhIL-12(p70) has preferable repairing effect, and catechin individually makes
Used time, face cream provided by the invention passed through catechin and rhIL-12(p70) and other compositions without repairing effect
Collective effect plays good hyperplastic scar repair, rapid-action, and has certain whitening effect, reduces recombined human
The dosage of interleukin 12, reduces costs, and lacks catechin or rhIL-12(p70) and all can obviously weaken and repairs
Multiple effect.
The clinical test of the face cream provided by the invention of test example three
It chooses caused by deep II degree or more the serious burn and scald that Guangzhou hospital in March, 2015~2015 year are accepted for medical treatment December
62 people of hyperplastic scar patient volunteer (male 29 people, 33 people of female, the age 19~46 years old, average age 32.7 years old) carries out Hypertrophic
The repairing test of scar the burn and scald course of disease 0.5~4 month, has formed hyperplastic scar, scar thickness is in 1.86~2.21mm
Between, scar tissue color is ruddy, and quality is hard.Hyperplastic scar patient volunteer is randomly divided into 2 groups, every group of 31 people, 2 groups
Between do not have statistical difference, treated respectively using the face cream of the embodiment of the present invention one and commercially available lavender scar cream
It repairs, smears 2 times daily, periodically carry out follow-up, and treatment results are as shown in table 2 after counting 3 months.
The standard of curative effect evaluation are as follows: cure: pain is itched, sense disappearance of burning, and scar tissue color is dimmed, and quality softens, surface light
Sliding, appearance is felt good；Effective: pain is itched, the basic disappearance of sense of burning, and scar largely softens, and appearance feels preferable；It is effective: pain,
Itch, burn and feel substantially reduced, scar atrophy to a certain degree, scar height reduces；It is invalid: pain, itch, burn sense without it is substantially reduced or add
Weight, scar color, size, highly without substantially changeing.
The clinical therapeutic efficacy of the face cream provided by the invention of table 2
| It cures | It is effective | Effectively | In vain | Average scar thickness/mm | Total effective rate | |
| One group of embodiment | 7 | 19 | 5 | 0 | 0.425 | 100% |
| Positive controls | 1 | 14 | 12 | 4 | 0.796 | 87.1% |
As known from Table 2, face cream provided by the invention has significant repairing effect to hyperplastic scar, and total effective rate is
Average scar highly significant after 100%, treatment 3 months is reduced to 0.425mm, has no adverse reaction, hence it is evident that better than the positive
Control group.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to of the invention
Protection scope.
Claims (8)
1. a kind of face cream for hyperplastic scar reparation, it is characterised in that: including following component and its parts by weight: onion
0.1~2 part of bulb extract, 0.01~0.5 part of Gotu Kola P.E, 0.1~2 part of beta glucan, 1~5 part of catechin, recombination
0.0002~0.002 part of hIL-12,1~5 part of saualane, 1~3 part of wheat-germ oil, cetearyl glucose
2~4 parts of glycosides, 1~5 part of isopropyl myristate, 1~5 part of ethylhexyl palmitate, 0.5~2 part of octyl methoxycinnamate,
1~5 part of glycerol, 0.5~2 part of cetostearyl alcohol, 0.5~2 part of propylene glycol and 70~85 parts of water.
2. the face cream according to claim 1 for hyperplastic scar reparation, it is characterised in that: including following component and
Its parts by weight: 0.5~1.5 part of onion bulb stem extract, 0.1~0.4 part of Gotu Kola P.E, beta glucan 0.5~1.5
Part, 2~4 parts of catechin, 0.0005~0.0015 part of rhIL-12(p70), 2~4 parts of saualane, wheat-germ oil 1
~3 parts, 2~4 parts of cetearyl glucoside, 3~5 parts of isopropyl myristate, 2~4 parts of ethylhexyl palmitate, methoxyl group
1~2 part of cinnamic acid monooctyl ester, 3~5 parts of glycerol, 1~2 part of cetostearyl alcohol, 0.5~2 part of propylene glycol and 70~80 parts of water.
3. the face cream according to claim 1 or 2 for hyperplastic scar reparation, it is characterised in that: further include anti-corrosion
0.1~0.5 part of agent.
4. the face cream according to claim 3 for hyperplastic scar reparation, it is characterised in that: including following component and
Its parts by weight: 1 part of onion bulb stem extract, 0.2 part of Gotu Kola P.E, 1.2 parts of beta glucan, 3 parts of catechin, recombined human
0.0008 part of interleukin 12,3 parts of saualane, 2 parts of wheat-germ oil, 3 parts of cetearyl glucoside, myristic acid are different
4 parts of propyl ester, 3 parts of ethylhexyl palmitate, 1 part of octyl methoxycinnamate, 4 parts of glycerol, 1.4 parts of cetostearyl alcohol, propylene glycol 1
Part, 0.2 part of preservative, 72 parts of water.
5. the face cream according to claim 3 for hyperplastic scar reparation, it is characterised in that: the preservative is anti-
Bacterium peptide.
6. the face cream according to claim 1 or 2 for hyperplastic scar reparation, it is characterised in that: the β-Portugal is poly-
Sugar is yeast beta-dextran.
7. the preparation method of the face cream according to claim 1 for hyperplastic scar reparation, it is characterised in that: including
Following steps:
S1 weighs saualane, wheat-germ oil, cetearyl glucoside, isopropyl myristate, ethylhexyl palmitate, first
Oxygroup cinnamic acid monooctyl ester and cetostearyl alcohol are stirred and heated to 80~85 DEG C in first reactor, obtain material A, heat preservation
It is spare；
S2 weighs glycerol, propylene glycol and water in second reactor, is stirred and heated to 80~85 DEG C, is slowly added to the material
A stirs homogeneous, obtains material B；
The material B is cooled to 40~45 DEG C by S3, and it is poly- to weigh and be added onion bulb stem extract, Gotu Kola P.E, β-Portugal
Sugar, catechin and rhIL-12(p70), stir evenly, cooling, obtain the face cream for hyperplastic scar reparation.
8. the preparation method of the face cream according to claim 7 for hyperplastic scar reparation, it is characterised in that: described
Step S3 further includes the steps that weighing and antibacterial peptide is added.
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| CN107753350A (en) * | 2017-12-05 | 2018-03-06 | 北京军秀咨询有限公司 | A kind of plant extract has the face cream that scar repairs striae of pregnancy reparation |
| CN109125173A (en) * | 2018-09-19 | 2019-01-04 | 李燕 | A kind of face cream and preparation method thereof removing striae of pregnancy |
| CN111671684A (en) * | 2020-06-11 | 2020-09-18 | 伍丽娟 | Skin cream for fading scars |
| CN112754974B (en) * | 2021-01-18 | 2022-03-18 | 珀莱雅化妆品股份有限公司 | Composition with anti-allergy repairing effect and preparation method thereof |
| CN118178250A (en) * | 2024-05-15 | 2024-06-14 | 珠海安和生化科技有限公司 | Skin stripping post-repair composition and application thereof |
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| CN101327179A (en) * | 2008-07-31 | 2008-12-24 | 曹智华 | Medicinal cosmetics for treating acne and scar thereof with antianaphylaxis function |
| CN101837071A (en) * | 2010-02-12 | 2010-09-22 | 浙江康恩贝健康产品有限公司 | Composition of plant extracts and application in preventing or treating scars |
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| EP1444989A1 (en) * | 2003-02-07 | 2004-08-11 | Giorgio Dr. Stassi | Sensitizing cells for apoptosis by selectively blocking cytokines |
| US7399783B2 (en) * | 2005-06-22 | 2008-07-15 | The Quigley Corporation | Methods for the treatment of scar tissue |
| CN102038937B (en) * | 2009-10-12 | 2014-12-17 | 张志群 | External medicament for treating dermatosis and anti-aging and preparation method thereof |
| CN102641217A (en) * | 2012-05-07 | 2012-08-22 | 广州市恺泰生物科技有限公司 | Application of interleukin-12 in facial beautifiers |
| US20140274896A1 (en) * | 2013-03-15 | 2014-09-18 | G1 Therapeutics, Inc. | Transient Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation |
| CN103432114A (en) * | 2013-08-20 | 2013-12-11 | 云南农业大学 | Application of epigallocatechin gallate to preparation of drugs for promoting epidermal repair and regeneration |
| CN103495155B (en) * | 2013-09-25 | 2015-10-14 | 南阳市汇博生物技术有限公司 | For pad pasting that hypertrophic cicatrix is repaired and preparation method thereof |
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| CN101327179A (en) * | 2008-07-31 | 2008-12-24 | 曹智华 | Medicinal cosmetics for treating acne and scar thereof with antianaphylaxis function |
| CN101837071A (en) * | 2010-02-12 | 2010-09-22 | 浙江康恩贝健康产品有限公司 | Composition of plant extracts and application in preventing or treating scars |
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