CN106075399A - For the compositions of corticosteroid dermatitis, preparation and preparation method and application - Google Patents

For the compositions of corticosteroid dermatitis, preparation and preparation method and application Download PDF

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CN106075399A
CN106075399A CN201610587557.9A CN201610587557A CN106075399A CN 106075399 A CN106075399 A CN 106075399A CN 201610587557 A CN201610587557 A CN 201610587557A CN 106075399 A CN106075399 A CN 106075399A
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growth factor
preparation
compositions
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parts
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简婷婷
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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Abstract

The present invention relates to biomedicine field, be specifically related to a kind of be applicable to the compositions of corticosteroid dermatitis, preparation and its preparation method and application.Described compositions includes following composition: MEIGUI CHUNLU, Semen Vitis viniferae extract, Aloe glue, Radix Glycyrrhizae extract, curcumin, apigenin, Herba bromi japonici beta glucan, glycosaminoglycan, water-solubleazone, polylysine, watermiscible vitamin E, Jojoba wax, 1,2 glutaraldehydes, composite growth factor, hydroxypropyl beta cyclodextrin, EDTA 2Na, collagen protein, wetting agent, adjuvant and natural antiseptic agent.The middle composition of said composition to skin action temperature and; nonirritant; composition is collocated with each other can be on the basis of providing moisturizing; prevent inflammation, the anaphylaxis caused by corticosteroid dermatitis; the skin that suppression bacterial invasion has damaged, the composite growth factor of addition more can promote skin corium, the metabolism of epidermal area, especially corneocyte and reparation, promotes the formation of intercellular substance; thus damaged skin is repaired, reach protection and the effect for the treatment of.

Description

For the compositions of corticosteroid dermatitis, preparation and preparation method and application
Technical field
The present invention relates to biomedicine field, be specifically related to a kind of compositions for corticosteroid dermatitis, preparation and preparation Methods and applications.
Background technology
Steroid-dependent dermatitis is the dermatitis caused because of the prolonged and repeated hormone of external improperly, shows as external sugar cortical hormone After element, primary skin lesion disappears, but occurs again inflammatory damage after disabling, and needs Reusability glucocorticoid to control symptom gradually A kind of dermatitis increased the weight of.
Corticosteroid dermatitis morbidity detailed mechanism is still not clear, but now with following several sayings:
Skin barrier function is impaired, and long-term external hormone preparation is a lot of to skin barrier function Slope protection, including:
1, suppression skin keratin forms cell (KC) propagation, affects keratin, the differentiation of intermediate filament's polymeric protein and impact Keratinization desmosome, the formation etc. of KC interstitial.Skin barrier function is impaired, can activate interleukin-6 (IL-6), IL-1 α, tumor bad The inflammatory cytokines such as necrosis factor-α (TNF-α), granulocyte colony-stimulating factor (GSF), induce further, increase the weight of dermal inflammatory Reaction.
2, epidermis and corium are thinning, and prolonged application hormone causes patient skin horny layer, papillary layer of corium atrophy thinning.Outward With hindering epidermis cell mitosis and cell DNA synthesis, suppression keratinocyte proliferation and differentiation during hormone.And hormone meeting By interference epidermal proliferation, make keratohyaline layer granule reduce, finally make atrophy of epidermis thinning；Meanwhile, collage synthesis is further Reduce, the atrophy in succession of vascular endothelial cell, smooth muscle cell and elastic fibers, directly result in corium thinning.
3, face microorganism is infected, and hormone can suppress macrophage function, affects the effect of Langerhans cell, dissolves and drenches Bar cell, so that skin surface Effects on local immunological functions reduces.Having research display, external glucocorticoid can promote skin of face Middle yeast and the excessive multiplication of other pathogenic microorganism, cause microorganism to produce a large amount of (surpassing) antigen, when hormone immunity suppresses Act on the immunoreation of (surpassing) antigen mediation after suddenly disappearing to be activated because of the release of cell medium, meanwhile, discharge inflammation Medium, thus increase the weight of the inflammatory reaction of skin surface.
After external the 1950's hydrocortisone treatment dermatosis is successful, (the letter of external glucocorticoid Claiming hormone) preparation is widely used at department of dermatologry.In order to treat primary disease, such as seborrheic dermatitis, rosacea, wet Rash, psoriasis, lupus erythematosus etc. and life-time service hormone；Also have for beauty treatment and eliminating spot, brighten skin care and use mistakenly for a long time Cosmetics containing hormone, the patients with glucocorticoid dermatitis thus caused is more and more common.Skin of face is thin because of horny layer, contains Abundant sebaceous gland, good penetrability, easily absorb, thus face is corticosteroid dermatitis district occurred frequently, face corticosteroid dermatitis is easy to Cause atrophoderma, thinning, telangiectasis, pigmented spots, the untoward reaction such as skin aging, bring to patient's physiology, psychology The biggest puzzlement.
Clinically mainly with antiinflammatory, immunomodulating, the barrier function of reparation skin, the microorganism life of suppression skin surface Length etc. are as the Therapeutic Principle of corticosteroid dermatitis, but treatment time is long, and the most repeatedly, and multiplex Drug therapy, side effect Bigger.
Summary of the invention
The present invention need solve problem of the prior art be: the existing material for corticosteroid dermatitis, its treatment time Between long, and easily the most repeatedly, and side effect is bigger.
For solving problem above, the invention provides a kind of compositions for corticosteroid dermatitis, and preparation method and Purposes.
Specifically, the invention provides a kind of compositions for corticosteroid dermatitis, described compositions includes as follows Composition:
MEIGUI CHUNLU, Semen Vitis viniferae extract, Aloe glue, Radix Glycyrrhizae extract, curcumin, apigenin, Herba bromi japonici-beta glucan, Glycosaminoglycan, water-solubleazone, polylysine, watermiscible vitamin E, Jojoba wax, 1,2-glutaraldehyde, composite growth because of Son, HP-β-CD, EDTA-2Na, collagen protein, wetting agent, adjuvant and natural antiseptic agent.
Preferably, by weight, described compositions includes:
MEIGUI CHUNLU 50-90 part, preferably 85 parts；
Semen Vitis viniferae extract 0.001-0.1 part, preferably 0.1 part；
Aloe glue 0.1-1.0 part, preferably 0.5 part；
Radix Glycyrrhizae extract 0.1-1.0 part, preferably 0.3 part；
Curcumin 0.1-1.0 part, preferably 0.5 part；
Apigenin 0.1-1.0 part, preferably 0.5 part；
Herba bromi japonici-beta glucan 0.5-2 part, preferably 1 part；
Glycosaminoglycan 0.01-1 part, preferably 0.1 part；
Water-solubleazone 0.1-5 part, preferably 1 part；
Polylysine 0.01-0.1 part, preferably 0.05 part；
Watermiscible vitamin E 1-3 part, preferably 2 parts；
Jojoba wax 0.1-1 part, preferably 0.5 part；
1,2-glutaraldehyde 1-5 part, preferably 2 parts；
Composite growth factor 0.0001-0.001 part, preferably 0.0003 part；
HP-β-CD 0.5-5 part, preferably 1.5 parts,
EDTA-2Na 0.01-0.1 part, preferably 0.08 part,
Collagen protein 0.1-1 part, preferably 0.5 part；
Wetting agent 1-10 part, preferably 3 parts；
Adjuvant 1-5 part, preferably 2.5 parts；
With natural antiseptic agent 0.5-5 part, preferably 1.5 parts.
Preferably, described composite growth factor, including epidermal growth factor (EGF), acid fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF) and keratinocyte growth factor (KGF).
Preferably, described epidermal growth factor (EGF), acid fibroblast growth factor (aFGF), basic fibroblast Cell growth factor (bFGF), the weight ratio of keratinocyte growth factor (KGF) be: (1-5): (1-5): (0.1-0.5): (0.1-0.5)。
Preferably, more than one or more in allantoin, glycerol or 1,3 butylene glycol of described wetting agent, preferably Whole for allantoin, glycerol and 1,3 butylene glycol.
Preferably, one or more in poloxamer, Polyethylene Glycol, the polyvinylpyrrolidone of described adjuvant with On.
Preferably, described natural antiseptic agent one or several in chitosan, polylysine, bitter edible plant polyphenol, garlicin More than Zhong.
Present invention also offers a kind of preparation for corticosteroid dermatitis, it uses containing the combination described in any of the above item The raw material of thing is made.
Preferably, the dosage form of described preparation is solution, Emulsion or unguentum.
Meanwhile, the invention provides the preparation method of a kind of solution for corticosteroid dermatitis, comprise the steps:
(1) the composition deionized water in A phase is fully dissolved, be heated to 121 DEG C of sterilizings；
(2) B is added to A phase, stirring and dissolving；
(3) C phase, stirring and dissolving are added；
(4) aseptically, adding the D phase through filtration sterilization, stirring and evenly mixing obtains the solution for corticosteroid dermatitis Agent；
Wherein, described A phase is: MEIGUI CHUNLU, 1,2-glutaraldehyde, polylysine, HP-β-CD, EDTA-2Na, Jojoba wax, watermiscible vitamin E, part wetting agent and adjuvant；
Described B phase is: Semen Vitis viniferae extract, Aloe glue, Radix Glycyrrhizae extract, curcumin, apigenin, Herba bromi japonici-beta glucan, Glycosaminoglycan, water-solubleazone；
Described C phase is: part wetting agent, collagen protein, natural antiseptic agent；
Described D phase is: composite growth factor.
Preferably, in step (2), whipping temp is 70-80 DEG C, and mixing time is 20-40 minute.
Preferably, in step (3), whipping temp is 50-70 DEG C, and mixing time is 20-40 minute.
Invention also provides the compositions described in any of the above item or the preparation described in any one preparation for Treatment or the medicine of reparation corticosteroid dermatitis or preparation are used for the application in skin care product.
The skin care liquid of the different dosage form that the compositions of the employing present invention prepares uses aseptic subpackaged sealing to be stored in 4 ℃。
According to the pathogenesis of corticosteroid dermatitis, this formula adds the anti-inflammatory of extracted form natural plant, antianaphylactic Material；Plant extract moisturizing ingredient；Composite growth factor used by skin repair；Safe and non-stimulating broad spectrum antimicrobicide, in addition It is also added into corresponding stabilizer and adjuvant.
The natural anti-inflammatory of the plant extract wherein contained, antianaphylactic material include Semen Vitis viniferae extract, Aloe glue, sweet Grass extracting solution, curcumin, apigenin, oat beta-glucan, MEIGUI CHUNLU, glycosaminoglycan etc., also contain the antiallergic thing of gentleness Matter water-solubleazone；
The antibacterial added is polylysine, and polylysine is a kind of natural biological metabolic product, and antimicrobial spectrum is extensive, can With suppression most antibacterial, the growth of fungus, it is to avoid use antibiotic and chemical classes (such as phenoxyethanol, parabens) are antibacterial The agent stimulation to skin.
In addition Herba bromi japonici-beta glucan, Aloe glue, MEIGUI CHUNLU, glycosaminoglycan can play good moisturizing, reparation Effect；Semen Vitis viniferae extract, watermiscible vitamin E, Aloe glue etc., as antioxidant, can eliminate free radical, and they are common A good microenvironment is provided to the metabolism of Skin Cell, reparation.
With the addition of a certain proportion of somatomedin in maintenance liquid, according to mass ratio, EGF:aFGF:bFGF:KGF is (1-5): (1-5) ratio that: (0.1-0.5): (0.1-0.5), this ratio is combined with skin repair test effect and economic factor determines. EGF can promote going up again of the proliferation and differentiation such as epidermis cell, fibroblast and migration, the formation of promotion new granulation tissue and wound surface Pi Hua；Promote hyaluronic acid, fibronectin, the synthesis of the sugar extracellular matrix such as egg albumen and hydroxyproline；aFGF、bFGF Promote vascular endothelial cell and fibroblast division growth, accelerate granulation tissue and formed；Promote fibroblast release collagen Enzyme, fibrinolytic kinases.KGF stimulates the propagation of epithelial cell, migrates and break up, and promotes that keratinocyte proliferation thickens, promotes sebaceous gland Sweat gland grows.Four kinds of somatomedin synergism, promote corium and the metabolism of epidermis cell and reparation, promote the shape of intercellular substance Become, thicken horny layer, make damaged skin rebuild, the final normal barrier action recovering skin.
In repair liquid component effect skin gentle, non-stimulated and have very well to the skin having suffered from corticosteroid dermatitis Repair, therefore can also use as daily skin care solution.
The invention has the beneficial effects as follows: in the compositions of the present invention composition to skin action temperature and, nonirritant, become split-phase Collocation can prevent, on the basis of providing moisturizing, inflammation, the anaphylaxis caused by corticosteroid dermatitis mutually, suppresses bacterial invasion The skin damaged, the composite growth factor of addition more can promote skin corium, the metabolism of epidermal area, especially corneocyte and Repair, promote the formation of intercellular substance, thus damaged skin is repaired, reach protection and the effect for the treatment of；Simultaneously this The preparation of the different dosage form that bright compositions prepares, non-stimulated and there is good repair, can be as daily Skin care solution uses.
Detailed description of the invention
As it has been described above, it is an object of the invention to: provide a kind of compositions for corticosteroid dermatitis, and preparation method And purposes.
The preparation of the different dosage form that the compositions of the employing present invention prepares, can be as required to smear or wiping Mode for corticosteroid dermatitis patient, it is also possible to for the daily skin protection of general population.
Wherein, MEIGUI CHUNLU, is the fresh rose flower that will newly pluck, and puts alembic into, carry out after sealing fragrance with salt stirring Make after oil-water separation.The fresh rose flower specifically will newly plucked, processes immediately, seals flower with salt stirring and distributes perfume (or spice) Taste, the flower after sealing carries out distillation processing.Flower is put into alembic, and steam heating distillation under pressure, the steam after distillation is cold But condensation forms distilled water, enters oil water separator.Under low temperature, in oil water separator quintessence oil upper distillate under, after separation The extraction of essential oil on upper strata enter quintessence oil storage container, distillate below is recycled in alembic continuing heating evaporation.Cause The quintessence oil not having defecation it is contained within for this part distillate.Moving in circles, until extraction of essential oil is complete, the most remaining liquid is exactly MEIGUI CHUNLU.
Semen Vitis viniferae extract, is the new and effective natural anti-oxidation that can not synthesize in a kind of human body of extraction from Semen Vitis viniferae Agent, main component is procyanidin.
Curcumin, is a kind of chemical composition extracted in the rhizome of some plants from Zingiberaceae, Araeceae.Wherein, Rhizoma Curcumae Longae accounts for 3%～6%.
Radix Glycyrrhizae extract, is by the dry root of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. and the Glycyrrhiza glabra L. of pulse family Glycyrrhiza and stem The Radix Glycyrrhizae extract obtained after extraction, comprises Licorice flavanone, Licoflavone A, Licoflavonol. A, licocoumarone, the different Huang of Radix Glycyrrhizae Ketone A, licoisoflavanone B and licoisoflavanone etc..
Aloe glue, application freeze-stable technology extraction of substance from herbaceous plant Aloe processes.
Apigenin, is flavone compound, is distributed in vegetable and the fruit of warm band, especially high with content in Herba Apii graveolentis, Some medical herbs such as Semen Plantaginis, Caulis Trachelospermi etc. also have the highest content.Its chemical constitution is Apigenin, Molecular formula is C15H10O6。
Each composition in compositions used in the present invention, is the composition that those skilled in the art commonly use, Ke Yitong Crossing and buy or be commercially available, the content of different manufacturers its main active possible has little difference, but has no effect on this Invent the reparation for corticosteroid dermatitis and therapeutic effect.The present invention is made further details of below in conjunction with detailed description of the invention Explanation.Wherein, the purity of used in embodiment raw material and model and production firm are shown in Table 1.
Table 1 present invention is raw materials used and manufacturer
Embodiment one
Embodiment one provides a kind of skin repair liquid being applicable to corticosteroid dermatitis, and its composition is as follows:
In parts by weight,
A phase is: MEIGUI CHUNLU 85 parts, polylysine 0.05 part, 0.50 part of Jojoba wax, 1,2-glutaraldehyde 2.00 parts, hydroxyl Propyl-beta-cyclodextrin 1.50 parts, EDTA-2Na0.08 part, watermiscible vitamin E 2.00 parts, poloxamer188 2.50 parts, sweet Oil 1.00 parts, 1,3 butylene glycol 3.00 parts；
B phase: Semen Vitis viniferae extract 0.01 part, Aloe glue 0.50 part, Radix Glycyrrhizae extract 0.30 part, curcumin 0.50 part, celery Dish element 0.50 part, Herba bromi japonici-beta glucan 1.00 parts, glycosaminoglycan 0.10 part, water-solubleazone 1.00 parts；
C phase: allantoin 0.20 part, micromolecular collagen 0.50 part, chitosan 1.50 parts；
D phase: composite growth factor 0.0003 part (i.e. makes composite growth factor repair at the final hormone dermatitis prepared Concentration in solution is 3 mcg/ml, and wherein EGF, aFGF, bFGF, KGF mass ratio is 5:5:0.5:0.5).
Above weight portion represents the weight ratio of each component, and in the embodiment of the present invention one, each component is according to above weight proportion essence Really weigh, weigh A phase altogether, B phase, C phase constituent mass each with D phase sum are 1000g.
The preparation method for the skin repair liquid of corticosteroid dermatitis of embodiment one is as follows:
(1) composition in A phase is fully dissolved with deionized water in emulsifying pot, be heated to 121 DEG C of sterilizings, be cooled to 80 ℃；
(2) B is added to A phase, 80 DEG C stirring 30 minutes after be cooled to 60 DEG C；
(3) adding C phase, 60 DEG C are stirred 30 minutes, are cooled to 30 DEG C；
(4) by the composite growth factor of filtration sterilization, according to mass ratio (EGF:aFGF:bFGF:KGF is 5:5:0.5: 0.5) add in above-mentioned composition, and stirring and evenly mixing obtains skin care liquid so that the volume of final skin care liquid is 1000ml.This skin protection The aseptic subpackaged sealing of liquid is stored in 4 DEG C.
Embodiment two
Embodiment two provides a kind of skin repair liquid being applicable to corticosteroid dermatitis, and its composition is as follows:
In parts by weight, A phase is: MEIGUI CHUNLU 50 parts, polylysine 0.01 part, 1.00 parts of Jojoba wax, 1,2-penta 2 5.00 parts of aldehyde, HP-β-CD 5.00 parts, EDTA-2Na 0.01 part, watermiscible vitamin E 2.00 parts, polyvinyl pyrrole Alkanone 0.5 part, glycerol 1.00 parts；
B phase: Semen Vitis viniferae extract 0.1 part, Aloe glue 1.0 parts, Radix Glycyrrhizae extract 1.0 parts, curcumin 0.10 part, apigenin 0.10 part, Herba bromi japonici-beta glucan 2.00 parts, glycosaminoglycan 1.00 parts, water-solubleazone 0.10 part；
C phase: allantoin 0.20 part, micromolecular collagen 0.50 part, bitter edible plant polyphenol 5.00 parts；
D phase: composite growth factor 0.001 part (i.e. makes composite growth factor repair at the final hormone dermatitis prepared Concentration in solution is 10 mcg/ml, and wherein EGF, aFGF, bFGF, KGF mass ratio is 1:3:0.1:0.3).
Above weight portion represents the weight ratio of each component, and in the embodiment of the present invention one, each component is according to above weight proportion essence Really weigh, weigh A phase altogether, B phase, C phase constituent mass each with D phase sum are 1000g.
The preparation method for the skin repair liquid of corticosteroid dermatitis of embodiment two is as follows:
(1) composition in A phase is fully dissolved with deionized water in emulsifying pot, be heated to 121 DEG C of sterilizings, be cooled to 70 ℃；
(2) B is added to A phase, 70 DEG C stirring 40 minutes after be cooled to 60 DEG C；
(3) adding C phase, 50 DEG C are stirred 40 minutes, are cooled to 30 DEG C；
(4) by the composite growth factor of filtration sterilization, according to mass ratio (EGF:aFGF:bFGF:KGF is 1:3:0.1: 0.3) add above-mentioned composition and stirring and evenly mixing obtains skin care liquid so that the volume of final skin care liquid is 1000ml.This skin care liquid Aseptic subpackaged sealing is stored in 4 DEG C.
Embodiment three
Embodiment three provides a kind of skin repair liquid being applicable to corticosteroid dermatitis, and its composition is as follows:
In parts by weight, A phase is: MEIGUI CHUNLU 85 parts, polylysine 0.10 part, 0.10 part of Jojoba wax, 1,2-penta 2 1.00 parts of aldehyde, HP-β-CD 0.50 part, EDTA-2Na0.10 part, watermiscible vitamin E 2.00 parts, Polyethylene Glycol 5.00 parts, glycerol 5.00 parts, 1,3 butylene glycol 3.00 parts；
B phase: Semen Vitis viniferae extract 0.001 part, Aloe glue 0.10 part, Radix Glycyrrhizae extract 0.10 part, curcumin 1.00 parts, celery Dish element 1.00 parts, Herba bromi japonici-beta glucan 0.50 part, glycosaminoglycan 0.01 part, water-solubleazone 5.00 parts；
C phase: allantoin 0.20 part, micromolecular collagen 0.50 part, garlicin 0.50 part；
D phase: composite growth factor 0.0001 part (i.e. makes composite growth factor repair at the final hormone dermatitis prepared Concentration in solution is 1 mcg/ml), wherein EGF, aFGF, bFGF, KGF mass ratio is 3:1:0.3:0.1.
Above weight portion represents the weight ratio of each component, and in the embodiment of the present invention one, each component is according to above weight proportion essence Really weigh, weigh A phase altogether, B phase, C phase constituent mass each with D phase sum are 1000g.
The preparation method for the skin repair liquid of corticosteroid dermatitis of embodiment three is as follows:
(1) composition in A phase is fully dissolved with deionized water in emulsifying pot, be heated to 121 DEG C of sterilizings, be cooled to 80 ℃；
(2) B is added to A phase, 80 DEG C stirring 20 minutes after be cooled to 70 DEG C；
(3) adding C phase, 70 DEG C are stirred 20 minutes, are cooled to 30 DEG C；
(4) by the composite growth factor of filtration sterilization, according to mass ratio (EGF:aFGF:bFGF:KGF is 3:1:0.3: 0.1) add above-mentioned composition and stirring and evenly mixing obtains skin care liquid so that the volume of final complex liquid is 1000ml.This skin care liquid Aseptic subpackaged sealing is stored in 4 DEG C.
Embodiment four
144 facial corticosteroid dermatitis patients, are randomly divided into treatment group and matched group, and wherein, therapeutic component does not use reality Executing the compositions prepared of example one, embodiment two and embodiment three, respectively 36 example, altogether 108 examples, matched group is 36 Example, what matched group used is the moisture retention liquid (wherein glycerol and allantoin weight ratio are 3:1) containing glycerol and allantoin.
Using method: after warm water face cleaning, takes appropriate skin care liquid and is applied in face, and every day twice sooner or later, period does not use it His skin care item and Drug therapy, persistently tries out 4 weeks.
Before use with use after observe respectively the symptom (pruritus, pain, tight etc.) of patient and sign (erythema, swelling, Desquamation, dry, facial telangiectasias, follicularis pimple etc.), observe untoward reaction simultaneously.To treat according to therapeutic index Effect be divided into recovery from illness, effective, effective, invalid 4 grades.Obvious effective rate=(recovery from illness+effective) number of cases/total number of cases × 100%；Effective percentage= (recovery from illness+effective+effectively) number of cases/total number of cases × 100%.
Wherein, recovery from illness: patient facial region's sings and symptoms all disappears, and symptom disappears substantially；
Effective: patient facial region's sings and symptoms major part disappears, and symptom substantially alleviates；
Effective: patient facial region's sings and symptoms partial remission, symptom makes moderate progress,
Invalid: patient facial region's sings and symptoms disappears inconspicuous, symptom has no and alleviates, even increase the weight of.
The each experimental result of table 3 experimental group
Corticosteroid dermatitis patient is treated by the employing embodiment of the present invention one to the compositions of embodiment three, and it is more right to compare According to group, treatment group is after smearing skin care liquid of the present invention one week, and being obviously improved occurs in patient facial region's symptom, erythema, swelling, be dried etc. Alleviating occurs in symptom.Treat two weeks to after surrounding, treatment group patient facial region's symptom is substantially all to disappear, and the matched group that compares occurs Significantly improve.From the results shown in Table 3, the skin care liquid that embodiment one prepares is used to the compositions of embodiment three To corticosteroid dermatitis, patient treats, and the recovery effective percentage of the corticosteroid dermatitis of patient is up to 97.2%, and does not has Significantly untoward reaction.
The foregoing is only present pre-ferred embodiments, be not used to limit to the present invention, all spirit in the present invention and former Amendment, equivalent and the improvement etc. made within then, within being required to be included in the protection domain of invention.

Claims (13)

1. the compositions for corticosteroid dermatitis, it is characterised in that: described compositions includes following composition:
MEIGUI CHUNLU, Semen Vitis viniferae extract, Aloe glue, Radix Glycyrrhizae extract, curcumin, apigenin, Herba bromi japonici-beta glucan, amino Glucosan, water-solubleazone, polylysine, watermiscible vitamin E, Jojoba wax, 1,2-glutaraldehyde, composite growth factor, hydroxyl Propyl-beta-cyclodextrin, EDTA-2Na, collagen protein, wetting agent, adjuvant and natural antiseptic agent.
Compositions the most according to claim 2, it is characterised in that by weight, described compositions includes:
MEIGUI CHUNLU 50-90 part, preferably 85 parts；
Semen Vitis viniferae extract 0.001-0.1 part, preferably 0.1 part；
Aloe glue 0.1-1.0 part, preferably 0.5 part；
Radix Glycyrrhizae extract 0.1-1.0 part, preferably 0.3 part；
Curcumin 0.1-1.0 part, preferably 0.5 part；
Apigenin 0.1-1.0 part, preferably 0.5 part；
Herba bromi japonici-beta glucan 0.5-2 part, preferably 1 part；
Glycosaminoglycan 0.01-1 part, preferably 0.1 part；
Water-solubleazone 0.1-5 part, preferably 1 part；
Polylysine 0.01-0.1 part, preferably 0.05 part；
Watermiscible vitamin E 1-3 part, preferably 2 parts；
Jojoba wax 0.1-1 part, preferably 0.5 part；
1,2-glutaraldehyde 1-5 part, preferably 2 parts；
Composite growth factor 0.0001-0.001 part, preferably 0.0003 part；
HP-β-CD 0.5-5 part, preferably 1.5 parts,
EDTA-2Na 0.01-0.1 part, preferably 0.08 part,
Collagen protein 0.1-1 part, preferably 0.5 part；
Wetting agent 1-10 part, preferably 3 parts；
Adjuvant 1-5 part, preferably 2.5 parts；
With natural antiseptic agent 0.5-5 part, preferably 1.5 parts.
Compositions the most according to claim 1 and 2, it is characterised in that described composite growth factor, including epidermal growth factor Son (EGF), acid fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF) and horn cell are raw The long factor (KGF).
Compositions the most according to claim 3, it is characterised in that described epidermal growth factor (EGF), acid fibroblast are thin The intracellular growth factor (aFGF), basic fibroblast growth factor (bFGF), the weight ratio of keratinocyte growth factor (KGF) For: (1-5): (1-5): (0.1-0.5): (0.1-0.5).
5. according to the compositions according to any one of claim 1-4, it is characterised in that described wetting agent selected from allantoin, More than one or more in glycerol or 1,3 butylene glycol, preferably allantoin, glycerol and 1,3 butylene glycol is whole.
6. according to the compositions according to any one of claim 1-5, it is characterised in that described adjuvant selected from poloxamer, More than one or more in Polyethylene Glycol, polyvinylpyrrolidone.
7. according to the compositions according to any one of claim 1-6, it is characterised in that described natural antiseptic agent gathers selected from shell More than one or more in sugar, polylysine, bitter edible plant polyphenol, garlicin.
8., for the preparation of corticosteroid dermatitis, it is former that it uses containing the compositions according to any one of claim 1-7 Material is made.
Preparation the most according to claim 8, it is characterised in that its dosage form is solution, Emulsion or unguentum.
10. the preparation method for the solution of corticosteroid dermatitis, it is characterised in that comprise the steps:
(1) the composition deionized water in A phase is fully dissolved, be heated to 121 DEG C of sterilizings；
(2) B is added to A phase, stirring and dissolving；
(3) C phase, stirring and dissolving are added；
(4) aseptically, adding the D phase through filtration sterilization, stirring and evenly mixing obtains the solution for corticosteroid dermatitis；
Wherein, described A phase is: MEIGUI CHUNLU, 1,2-glutaraldehyde, polylysine, HP-β-CD, EDTA-2Na, flash Bar wax, watermiscible vitamin E, part wetting agent and adjuvant；
Described B phase is: Semen Vitis viniferae extract, Aloe glue, Radix Glycyrrhizae extract, curcumin, apigenin, Herba bromi japonici-beta glucan, amino Glucosan, water-solubleazone；
Described C phase is: part wetting agent, collagen protein, natural antiseptic agent；
Described D phase is: composite growth factor.
11. preparation methoies according to claim 10, it is characterised in that in step (2), whipping temp is 70-80 DEG C, stirs The time of mixing is 20-40 minute.
12. according to the preparation method described in claim 10 or 11, it is characterised in that in step (3), whipping temp is 50-70 DEG C, mixing time is 20-40 minute.
Compositions described in 13. any one of claim 1-7 or the preparation described in claim 8 or 9 are used for treating in preparation Or repair medicine or the preparation application in skin care product of corticosteroid dermatitis.
CN201610587557.9A 2016-07-22 2016-07-22 For the compositions of corticosteroid dermatitis, preparation and preparation method and application Pending CN106075399A (en)

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CN106691923A (en) * 2016-12-12 2017-05-24 上海先妍生物技术有限公司 Composition and preparation for esthetic restoration, as well as preparation method and application thereof
CN106691923B (en) * 2016-12-12 2020-06-16 上海先妍生物技术有限公司 Composition and preparation for cosmetic repair, and preparation method and application thereof
CN108113923A (en) * 2017-12-21 2018-06-05 广东科玮生物技术股份有限公司 A kind of skin repair liquid and preparation method thereof
CN109966190A (en) * 2017-12-27 2019-07-05 武富明 A kind of external application extract for repairing hormone face
CN110769836A (en) * 2018-05-23 2020-02-07 浙江立恩生物科技有限公司 Biological polysaccharide for preventing and treating acne and hormone-dependent dermatitis and application thereof
CN110237236A (en) * 2018-07-25 2019-09-17 贝妮芙生物研究室株式会社 For treating the skin ointments of skin of labium minus
CN108904406A (en) * 2018-08-07 2018-11-30 广州市名宇化妆品制造有限公司 A kind of corticosteroid dermatitis remediation composition and preparation method thereof
CN111544427A (en) * 2019-02-12 2020-08-18 朱理查德澄朗 Composition for treating cancer and application thereof
CN111973620A (en) * 2019-05-21 2020-11-24 浙江立恩生物科技有限公司 Biological polysaccharide for preventing and treating hormone-dependent dermatitis and application thereof
WO2020233681A1 (en) * 2019-05-21 2020-11-26 浙江立恩生物科技有限公司 Biological polysaccharide having effect of preventing and treating hormone-dependent dermatitis and application thereof
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Application publication date: 20161109