CN110302132A - A kind of reparation spray and preparation method thereof of the filtrate of secretion containing snail - Google Patents
A kind of reparation spray and preparation method thereof of the filtrate of secretion containing snail Download PDFInfo
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Abstract
The invention belongs to technical field of skin care, and in particular to a kind of reparation spray and preparation method thereof of the filtrate of secretion containing snail.The reparation spray includes forming as follows: deionized water, myrrh extract, olibanum, notopterygium root extract, extractive of pubescent angelica root coumarin, safflower extract, camphor, rhizoma cyperi seed extract, decoyl hydroximic acid, propylene glycol, glycerol caprylate, methyl hydroxybenzoate, snail secretion filtrate, amino acid humectant, antioxidant and hydrolysis hyaluronic acid.Reparation spray of the invention can be with rapid recovery skin problem.
Description
Technical field
The invention belongs to the technical fields of skin care item, and in particular to the reparation spray of filtrate of secretion containing snail a kind of and
Preparation method.
Background technique
With the development of society, the raising of people's lives level, all in the life for pursuing high-quality, but with atmosphere
Pollution, the deterioration of environment, the irregular of people's life causes more and more skin problems to occur, due to repairing for snail itself
Multiple function and to skin the effect of, are found that snail pituitary extract is closed extensively as a kind of raw material for repairing product by people
Note.
Snail pituitary extract refers to a kind of mucus for playing lubricating action secreted in snail crawling process, and suspend mode is to use
Faucal is closed as barrier, main component is protein, gel, but in the crop of snail and alimentary canal there are also more than 20 kinds
Enzyme and various trace elements, can be secreted by gland line when snail is stimulated makes to contain organized enzyme and more in mucus in vivo
Effective component, form a kind of natural component comprising outstanding component with mucus, can promote skin regeneration and healing, snail is injured
Afterwards completely can be with self-regeneration, early in ancient Greek's period, snail has just been used for medical treatment side by the father " Hippocrates " of medicine
Face, his mixing milk with the snail treatment cutaneous scars pulverized, the function that Hippocrates records snail mucus have moisturizing,
Disappear red and swollen and anti-inflammatory analgesic, persistently becomes smooth bright using skin surface.Therefore the extract of snail mucus is produced as reparation
The raw material of product is expanded.
The existing type for repairing glusulase in either Protection Product containing snail secretion filtrate is few, the effect used
Fruit is less desirable, and in addition existing reparation stoste is all that being simply mixed for several components stirs to get, so that each group divides it
Between molecule binding ability it is poor, performance is not sufficiently stable under admixture, is easy to appear rotten, is influenced the time repaired and is used
Effect.
Summary of the invention
In view of the deficienciess of the prior art, the technical problem to be solved in the present invention is to provide one kind effectively to repair
Cutaneous pain, itch, redness, the common skin problem such as skin injury, can effectively promote containing for the repair ability of skin
The reparation spray and preparation method thereof of snail secretion filtrate.
To achieve the goals above, it is an object of the present invention to provide a kind of reparation of filtrate of secretion containing snail sprays
Agent is grouped as by following group:
A kind of reparation spray of the filtrate of secretion containing snail, including following component:
Deionized water, myrrh extract, Olibanum extract, notopterygium root extract, extractive of pubescent angelica root coumarin, safflower extract, camphor,
Rhizoma cyperi seed extract, decoyl hydroximic acid, propylene glycol, glycerol caprylate, methyl hydroxybenzoate, snail secretion filtrate, amino acid humectant,
Antioxidant and hydrolysis hyaluronic acid.
Preferably, these components include following parts by weight composition according to weight content:
Deionized water 25~80,1~4 part of myrrh extract, 1~4 part of Olibanum extract, 2~8 parts of notopterygium root extract, solely
2~8 parts of extract, 1~4 part of safflower extract, 0.1~1 part of camphor, 2~8 parts of rhizoma cyperi seed extract, decoyl hydroximic acid living
0.02~0.4 part, 1~6 part of propylene glycol, 0.01~0.5 part of glycerol caprylate, 0.01~0.2 part of methyl hydroxybenzoate, snail secretion filter
0.5~1 part of hyaluronic acid of 2~5 parts of liquid, 1~2 part of amino acid humectant, 3~5 parts of antioxidant and hydrolysis；
Preferably, including following parts by weight form:
Deionized water 30~60,2~3 parts of myrrh extract, 2~3 parts of Olibanum extract, 4~7 parts of notopterygium root extract, solely
4~7 parts of extract, 2~3 parts of safflower extract, 0.3~0.8 part of camphor, 4~7 parts of rhizoma cyperi seed extract, decoyl hydroximic acid living
0.04~0.3 part, 2~5 parts of propylene glycol, 0.05~0.3 part of glycerol caprylate, 0.05~0.15 part of methyl hydroxybenzoate, snail secretion
0.6~1 part of hyaluronic acid of 3~5 parts of filtrate, 1.2~1.8 parts of amino acid humectant, 3~4 parts of antioxidant and hydrolysis；
It is highly preferred that including that following parts by weight form:
Deionized water 50,2~2.5 parts of myrrh extract, 2~2.5 parts of Olibanum extract, 5 parts of notopterygium root extract, Radix Angelicae Pubescentis mention
Take 5 parts of object, 2~3 parts of safflower extract, 0.4 part of camphor, 5 parts of rhizoma cyperi seed extract, 0.09 part of decoyl hydroximic acid, propylene glycol 5
Part, 0.15 part of glycerol caprylate, 0.1 part of methyl hydroxybenzoate, snail secrete 4 parts of filtrate, 1.5 parts of amino acid humectant, antioxidant 4
0.6 part of hyaluronic acid of part and hydrolysis；
Preferably, the antioxidant is hydroxy acetophenone.
Another object of the present invention is realized through the following technical scheme:
A kind of preparation method of the reparation spray of the filtrate of secretion containing snail, which comprises the steps of:
A, 25~80 parts of water, 1~4 part of myrrh extract, 1~4 part of Olibanum extract, notopterygium root extract 2~8 are weighed respectively
Part, 2~8 parts of extractive of pubescent angelica root coumarin, 1~4 part of safflower extract, 0.1~1 part of camphor, 2~8 parts of rhizoma cyperi seed extract；Decoyl hydroxyl oxime
0.02~0.4 part of acid, snail secrete 2~5 parts of filtrate, 1~6 part of propylene glycol, 0.01~0.5 part of glycerol caprylate, methyl hydroxybenzoate
0.5~1 part of hyaluronic acid of 0.01~0.2 part, 1~2 part of amino acid humectant, 3~5 parts of antioxidant and hydrolysis；
B, the weighed water of step A, myrrh extract, Olibanum extract, notopterygium root extract, extractive of pubescent angelica root coumarin, safflower are mentioned
It takes object, camphor, rhizoma cyperi seed extract to be proportionally stirred mixing, heating stirring is carried out under germ-free condition, constant temperature stirring makes
After it is uniformly dissolved, solution a is obtained；
C, by propylene glycol weighed in step A, methyl hydroxybenzoate, amino acid humectant, antioxidant and hydrolysis hyaluronic acid
It is stirred mixing, the temperature remains within the normal range, obtains solution b；
D, snail weighed in step A secretion filtrate, decoyl hydroximic acid, glycerol caprylate are stirred under aseptic conditions
Mixing is mixed, obtains solution c after mixing；
E, solution a, solution b and solution c are stirred mixing, under germ-free condition, after mixing evenly, can be obtained containing snail
The reparation spray of ox secretion filtrate.
Preferably, the heating temperature in the step B is 75~90 DEG C.
Preferably, the thermostat temperature in the step B is 75~85 DEG C, and constant temperature time is 20~50min.
Preferably, solution a, solution b and the solution c in the step E are stirred between mixing, are cooled to room temperature.
Preferably, solution a, solution b and the solution c in the step E are filtered after being stirred mixing.
Preferably, above-mentioned all test procedures are completed under aseptic conditions.
Include following method in the extracting method of above-mentioned selection Chinese traditional medicine composition:
Myrrh can effectively control the pain of various stagnation of blood stasis, such as traumatic injury symptoms include injury pain, injured in the sinews or bones
Or torpor and swelling or internal injury hemostasis, trusted subordinate's pain, the diseases such as limb arm pain, (" Records of Tradition Chinese and Western Medicine in Combination ")；
The wherein preparation method of myrrh extract: taking myrrh, and 60 DEG C of ethyl alcohol of the 75% of 12 times of volumes of myrrh weight are added
Extraction 2 times, each 2h, combined extract, filtering, be concentrated and dried to get.
The preparation method of safflower extract: taking safflower, and the pure water of 10 times of volumes of safflower weight is added, and impregnates 15h, filters,
It takes filtered fluid to be condensed into paste, obtains condensed cream；The ethyl alcohol that volume fraction is 80% is added into the condensed cream and dissolves extracting,
Decompression removal ethyl alcohol, is drying to obtain.
Rhizoma Et Radix Notopterygii has and dissipates exterior cold, wind-damp dispelling, sharp joint, the effect of analgesic；
The preparation method of notopterygium root extract: taking Rhizoma Et Radix Notopterygii, and the pure water of 5 times of volumes of Rhizoma Et Radix Notopterygii weight is added, and impregnates 1h and is steamed using water
4h is extracted in the distillation of steam distillation method, collects distillate, is added sodium chloride to being saturated, is collected volatile oil, obtain notopterygium root extract.
Olibanum, blood-activating and qi-promoting；It is inducing meastruation to relieve menalgia；Detumescence and promoting granulation.Main trusted subordinate's pain；Rheumatic arthralgia；Amenorrhea and algomenorrhea；The bruise stasis of blood
Bitterly；Swollen ulcer drug；Acute appendicitis；Unhealing ulcer, ruptured abscess resistant to healing.Control qi and blood stagnation, trusted subordinate's pain, ulcerative carbuncle pyogenic infections, traumatic injury, dysmenorrhea, postpartum blood stasis
Shouting pain.
The wherein preparation method of Olibanum extract: taking olibanum, crushes, and the distilled water of 5 times of amounts is added, 2h is boiled in heating, cold
But and centrifugal filtering, filter residue heat again boils 0.5h, centrifugal filtering, and filter residue adds the ethyl alcohol that 1.5 times of amount concentration are 65%, flows back
4h is extracted, centrifugal filtering, 3 times repeatedly, ethyl alcohol is recovered under reduced pressure in merging filtrate, obtains extract；The method children's folk rhymes of the Olibanum extract
Suitable for notopterygium root extract.
Radix Angelicae Pubescentis is also known as houseleek, solely sliding, the dry root of Umbelliferae archangel Angelica pubescens；Wind toxin flaccidity of lower limbs numbness
Man Shangqi: five liang of Radix Angelicae Pubescentis, five liang of monkshood (raw to use, to cut).A pipeful of with wine, three place of stain warp is obeyed one and is closed and begin, is degree with micro- numbness.
(" Handbook of Prescriptions for Emergencies " Radix Angelicae Pubescentis wine).
The wherein preparation method of extractive of pubescent angelica root coumarin: taking Radix Angelicae Pubescentis, and the water that 8 times of weight are added impregnates 30min, is decocting 2h, mistake
Filter, filtrate is concentrated, and is spray-dried.
Rhizoma cyperi seed extract: taking the rhizome of nutgrass flatsedge, handles clean rear crushing, carries out concentration extraction by centrifugal extractor.
Snail secretion filtrate, the mucus secreted when snail creeps can be effectively prevented from skin aging, and can eliminate skin
On spot, scar and acne, snail secretion mucus contain natural allantoin, calcium, Glycolic acid, ossein, protein and Wei Sheng
Element etc. makes the essential material of cosmetics.In addition, mucus or a kind of natural antibiotics, can kill certain on skin
Bacterium, and skin speckle and acne can be eliminated, because of the third level that it can penetrate to the skin.The mucus of snail secretion contains
Chemical component have firming effect, skin rapid regeneration can be made.The allantoin extracted from snail mucus can make skin
Skin regeneration；Protein and vitamin can increase the nutrition of skin, keep skin finer and smoother and smooth.So snail secretion is filtered
Liquid have the effect of it is anti-inflammatory, repair, include protein in mucus, organized enzyme (cellulase, pectase, amylase, protease),
Mucoitin, chondroitin sulfate, proteoglycan, hydroxyacetic acid.
The acquisition of snail secretion filtrate: the snail of health is placed in clean mucus collecting box, by stimulating snail
Prolixity capsule and digestive secretion to obtaining snail secreting mucus, high speed centrifugation is crushed mucilage cell after mucus is collected, and goes
Supernatant can obtain the filter filtrate of the snail secretion containing glusulase.Moisturizing during extraction of snail secretion filtrate is viscous
The temperature of liquid is no more than 5 DEG C, and centrifugal process then needs to be handled at subzero 3 DEG C or less.
Decoyl hydroximic acid is a kind of organic acid of ideal type, has excellent antibacterial, bacteriostasis property under neutral pH,
It can be used for without chemical preservative formula system, decoyl hydroximic acid is acid all to keep having for not no ionized state to neutrality full name
Machine acid, is best antibacterial organic acid, there is highly effective chelating effect, and the active element for inhibiting mould to need limits micro-organisms
Required environment.
Glycerol caprylate can effectively inhibit breeding, the Multifunctional protective humectant, fatting agent of bacterium, primary efficacy: anti-Cuo
Sore activity:GMCY shows the activity of good anti-gram- bacteria, and is therefore improving anti-acne product effect
It is applied in terms of fruit for many years.
Antibacterial action: it can be seen that and all relevant microorganisms after a fungicidal composition compounding in challenge test
Quickly and effectively destroyed.
Moistening effect: the lipid part of human skin, therefore his hydrophilic radical are penetrated into and be adsorbed on to short close ester carbochain
It can be in the better moisturizing of cuticula.
Stuffing effect:GMCY can convey and retain oil components in skin surface.
Methyl hydroxybenzoate is a kind of white crystalline powder or colourless crystallization, is soluble in alcohol, ether and acetone, atomic to be dissolved in water, again
Claim methyl p-hydroxybenzoate.Be mainly used as organic synthesis, food, cosmetics, medicine sterilization antiseptic.
Benefit of the present invention
1, the propylene glycol in of the invention is that have the characteristic of fat-soluble solvent, and penetrating power is very strong, and solvability is big；It is pungent
Acyl hydroximic acid, can the effectively breeding of bacterium always, snail, which secretes filtrate, has preferable regeneration function to skin, has tight
The effect for causing skin can make skin keep best physiological status.
2, preparation method of the invention can be by the temperature in snail secretion filtrate and other compositions mixing process
With the time of stirring, the snail mucus and other compositions for being adequately are merged so that it is each it is intermolecular be combined with each other it is relatively stable,
The effect of snail secretion filtrate can be effectively played, safety is without side-effects, is easy to be less readily available for absorption by the skin, skin nutrition is supplemented,
Accelerate the recovery of skin problem.
3, reparation spray of the invention contains the snails such as the glusulase of bacteriostatic activity extraction bioactive substance, and albumen contains
Amount is high, and inhibitory potency effect is more preferable.Mucin full of nutrition is contained in snail secretion filter, and pro-skin easily absorbs, and wakes up skin
Reparative potential, neck skin pattern is fine and smooth, sense of touch lubrication.It is common to dermatitis (nerve), cutaneous pain, redness, pruitus etc.
Skin disease have certain effect.
Specific embodiment
Following embodiment is further described and illustrates to of the invention, rather than limiting the scope of the invention.Under
Face is further elaborated on the present invention referring to embodiment, it should be appreciated to those skilled in the art that the present invention is not limited to this
A little embodiments and the preparation method used.Moreover, those skilled in the art's description according to the present invention can to the present invention into
Row equivalent replacement, combination, improvement or modification, but these are intended to be included in the scope of the present invention.
Embodiment 1
A, 50 parts of deionized water, 1 part of myrrh extract, 1 part of Olibanum extract, 2 parts of notopterygium root extract, Radix Angelicae Pubescentis are weighed respectively
2.5 parts of extract, 1 part of safflower extract, 0.1 part of camphor, 2 parts of rhizoma cyperi seed extract；0.02 part of decoyl hydroximic acid, snail secretion
2 parts of filtrate, 1.5 parts of propylene glycol, 0.05 part of glycerol caprylate, 0.02 part of methyl hydroxybenzoate, 1 part of amino acid humectant, hydroxy benzenes second
0.5 part of hyaluronic acid of 3 parts of ketone and hydrolysis.
B, by the weighed deionized water of step A, myrrh extract, Olibanum extract, notopterygium root extract, extractive of pubescent angelica root coumarin,
Safflower extract, camphor, rhizoma cyperi seed extract are stirred mixing according to aforementioned proportion, and heating stirring is carried out under germ-free condition extremely
78 DEG C, constant temperature stirs 25min at a temperature of 75 DEG C, after making it dissolve uniformly, is cooled under normal temperature condition, obtains solution a；
C, by propylene glycol weighed in step A, methyl hydroxybenzoate, amino acid humectant, antioxidant and hydrolysis hyaluronic acid
It is stirred mixing, the temperature remains within the normal range, obtains solution b；
D, snail weighed in step A secretion filtrate, decoyl hydroximic acid, glycerol caprylate are stirred under aseptic conditions
Mixing is mixed, obtains solution c after mixing；
E, solution a, solution b and solution c are stirred mixing, under germ-free condition, after mixing evenly, filter out filter residue,
The reparation spray of the filtrate of secretion containing snail can be obtained.
Embodiment 2
A, 60 parts of deionized water, 2 parts of myrrh extract, 2 parts of Olibanum extract, 4 parts of notopterygium root extract, Radix Angelicae Pubescentis are weighed respectively
4 parts of extract, 2 parts of safflower extract, 0.3 part of camphor, 4 parts of rhizoma cyperi seed extract；0.04 part of decoyl hydroximic acid, snail secretion filter
4 parts of liquid, 3 parts of propylene glycol, 0.05 part of glycerol caprylate, 0.08 part of methyl hydroxybenzoate, amino acid humectant 1.5,3 parts of antioxidant and
0.7 part of hyaluronic acid of hydrolysis；
B, by the weighed deionized water of step A, myrrh extract, Olibanum extract, notopterygium root extract, extractive of pubescent angelica root coumarin,
Safflower extract, camphor, rhizoma cyperi seed extract are stirred mixing according to aforementioned proportion, and heating stirring is carried out under germ-free condition extremely
80 DEG C, constant temperature stirs 30min at a temperature of 80 DEG C, after making it dissolve uniformly, is cooled under normal temperature condition, obtains solution a；
C, by propylene glycol weighed in step A, methyl hydroxybenzoate, amino acid humectant, antioxidant and hydrolysis hyaluronic acid
It is stirred mixing, the temperature remains within the normal range, obtains solution b；
D, snail weighed in step A secretion filtrate, decoyl hydroximic acid, glycerol caprylate are stirred under aseptic conditions
Mixing is mixed, obtains solution c after mixing；
E, solution a, solution b and solution c are stirred mixing, under germ-free condition, after mixing evenly, filter out filter residue,
The reparation spray of the filtrate of secretion containing snail can be obtained.
Embodiment 3
A, weigh respectively 65 parts of deionized water, 2.5 parts of myrrh extract, 2.5 parts of Olibanum extract, 5 parts of notopterygium root extract,
5 parts of extractive of pubescent angelica root coumarin, 2.5 parts of safflower extract, 0.4 part of camphor, 5 parts of rhizoma cyperi seed extract；0.09 part of decoyl hydroximic acid, snail
Secrete 4 parts of filtrate, 3 parts of propylene glycol, 0.15 part of glycerol caprylate, 0.1 part of methyl hydroxybenzoate, 1.5 parts of amino acid humectant, anti-oxidant
0.6 part of hyaluronic acid of 4 parts of agent and hydrolysis；
B, by the weighed deionized water of step A, myrrh extract, Olibanum extract, notopterygium root extract, extractive of pubescent angelica root coumarin,
Safflower extract, camphor, rhizoma cyperi seed extract are stirred mixing according to aforementioned proportion, and heating stirring is carried out under germ-free condition extremely
85 DEG C, constant temperature stirs 45min at a temperature of 85 DEG C, after making it dissolve uniformly, is cooled under normal temperature condition, obtains solution a；
C, by propylene glycol weighed in step A, methyl hydroxybenzoate, amino acid humectant, antioxidant and hydrolysis hyaluronic acid
It is stirred mixing, the temperature remains within the normal range, obtains solution b；
D, snail weighed in step A secretion filtrate, decoyl hydroximic acid, glycerol caprylate are stirred under aseptic conditions
Mixing is mixed, obtains solution c after mixing；
E, solution a, solution b and solution c are stirred mixing, under germ-free condition, after mixing evenly, filter out filter residue,
The reparation spray of the filtrate of secretion containing snail can be obtained.
Embodiment 4
A, weigh respectively 70 parts of deionized water, 3.5 parts of myrrh extract, 3.5 parts of Olibanum extract, 7 parts of notopterygium root extract,
7 parts of extractive of pubescent angelica root coumarin, 3.5 parts of safflower extract, 0.9 part of camphor, 7 parts of rhizoma cyperi seed extract；0.3 part of decoyl hydroximic acid, snail
Secrete 5 parts of filtrate, 4.5 parts of propylene glycol, 0.4 part of glycerol caprylate, 0.18 part of methyl hydroxybenzoate, 1.6 parts of amino acid humectant, antioxygen
0.8 part of hyaluronic acid of 4 parts of agent and hydrolysis；
B, by the weighed deionized water of step A, myrrh extract, Olibanum extract, notopterygium root extract, extractive of pubescent angelica root coumarin,
Safflower extract, camphor, rhizoma cyperi seed extract are stirred mixing according to aforementioned proportion, and heating stirring is carried out under germ-free condition extremely
90 DEG C, constant temperature stirs 48min at a temperature of 85 DEG C, after making it dissolve uniformly, is cooled under normal temperature condition, obtains solution a；
C, propylene glycol weighed in step A, methyl hydroxybenzoate are stirred mixing, the temperature remains within the normal range, obtains solution b；
D, snail weighed in step A secretion filtrate, decoyl hydroximic acid, glycerol caprylate are stirred under aseptic conditions
Mixing is mixed, obtains solution c after mixing；
E, solution a, solution b and solution c are stirred mixing, under germ-free condition, after mixing evenly, filter out filter residue,
The reparation spray of the filtrate of secretion containing snail can be obtained.
Comparative example 1
A, 50 parts of deionized water, 1 part of myrrh extract, 1 part of Olibanum extract, 2 parts of notopterygium root extract, Radix Angelicae Pubescentis are weighed respectively
2.5 parts of extract, 1 part of safflower extract, 0.1 part of camphor, 2 parts of rhizoma cyperi seed extract；0.02 part of decoyl hydroximic acid, propylene glycol
1.5 parts, 0.05 part of glycerol caprylate, 0.02 part of methyl hydroxybenzoate, 1 part of amino acid humectant, 3 parts of hydroxy acetophenone and hydrolysis are transparent
0.5 part of matter acid.
B, by the weighed deionized water of step A, myrrh extract, Olibanum extract, notopterygium root extract, extractive of pubescent angelica root coumarin,
Safflower extract, camphor, rhizoma cyperi seed extract are stirred mixing according to aforementioned proportion, and heating stirring is carried out under germ-free condition extremely
78 DEG C, constant temperature stirs 25min at a temperature of 75 DEG C, after making it dissolve uniformly, is cooled under normal temperature condition, obtains solution a；
C, by propylene glycol weighed in step A, methyl hydroxybenzoate, amino acid humectant, antioxidant and hydrolysis hyaluronic acid
It is stirred mixing, the temperature remains within the normal range, obtains solution b；
D, decoyl hydroximic acid weighed in step A, glycerol caprylate are stirred mixing under aseptic conditions, mixing is equal
Solution c is obtained after even；
E, solution a, solution b and solution c are stirred mixing, under germ-free condition, after mixing evenly, filter out filter residue,
The reparation spray of the filtrate of secretion containing snail can be obtained.
Comparative example 2
A, 60 parts of deionized water, 2 parts of myrrh extract, 2 parts of Olibanum extract, 4 parts of notopterygium root extract, Radix Angelicae Pubescentis are weighed respectively
4 parts of extract, 2 parts of safflower extract, 0.3 part of camphor, 4 parts of rhizoma cyperi seed extract；0.04 part of decoyl hydroximic acid, 3 parts of propylene glycol,
0.05 part of glycerol caprylate, 0.08 part of methyl hydroxybenzoate, amino acid humectant 1.5,3 parts of antioxidant and hydrolysis hyaluronic acid 0.7
Part；
B, by the weighed deionized water of step A, myrrh extract, Olibanum extract, notopterygium root extract, extractive of pubescent angelica root coumarin,
Safflower extract, camphor, rhizoma cyperi seed extract are stirred mixing according to aforementioned proportion, and heating stirring is carried out under germ-free condition extremely
80 DEG C, constant temperature stirs 30min at a temperature of 80 DEG C, after making it dissolve uniformly, is cooled under normal temperature condition, obtains solution a；
C, by propylene glycol weighed in step A, methyl hydroxybenzoate, amino acid humectant, antioxidant and hydrolysis hyaluronic acid
It is stirred mixing, the temperature remains within the normal range, obtains solution b；
D, decoyl hydroximic acid weighed in step A, glycerol caprylate are stirred mixing under aseptic conditions, mixing is equal
Solution c is obtained after even；
E, solution a, solution b and solution c are stirred mixing, under germ-free condition, after mixing evenly, filter out filter residue,
The reparation spray of the filtrate of secretion containing snail can be obtained.
Comparative example 3
A, weigh respectively 65 parts of deionized water, 2.5 parts of myrrh extract, 2.5 parts of Olibanum extract, 5 parts of notopterygium root extract,
5 parts of extractive of pubescent angelica root coumarin, 2.5 parts of safflower extract, 0.4 part of camphor, 5 parts of rhizoma cyperi seed extract；0.09 part of decoyl hydroximic acid, the third two
3 parts of alcohol, 0.15 part of glycerol caprylate, 0.1 part of methyl hydroxybenzoate, 1.5 parts of amino acid humectant, 4 parts of antioxidant and hydrolysis are transparent
0.6 part of matter acid；
B, by the weighed deionized water of step A, myrrh extract, Olibanum extract, notopterygium root extract, extractive of pubescent angelica root coumarin,
Safflower extract, camphor, rhizoma cyperi seed extract are stirred mixing according to aforementioned proportion, and heating stirring is carried out under germ-free condition extremely
85 DEG C, constant temperature stirs 45min at a temperature of 85 DEG C, after making it dissolve uniformly, is cooled under normal temperature condition, obtains solution a；
C, by propylene glycol weighed in step A, methyl hydroxybenzoate, amino acid humectant, antioxidant and hydrolysis hyaluronic acid
It is stirred mixing, the temperature remains within the normal range, obtains solution b；
D, decoyl hydroximic acid weighed in step A, glycerol caprylate are stirred mixing under aseptic conditions, mixing is equal
Solution c is obtained after even；
E, solution a, solution b and solution c are stirred mixing, under germ-free condition, after mixing evenly, filter out filter residue,
The reparation spray of the filtrate of secretion containing snail can be obtained.
Comparative example 4
A, weigh respectively 70 parts of deionized water, 3.5 parts of myrrh extract, 3.5 parts of Olibanum extract, 7 parts of notopterygium root extract,
7 parts of extractive of pubescent angelica root coumarin, 3.5 parts of safflower extract, 0.9 part of camphor, 7 parts of rhizoma cyperi seed extract；0.3 part of decoyl hydroximic acid, snail
Secrete 5 parts of filtrate, 4.5 parts of propylene glycol, 0.4 part of glycerol caprylate, 0.18 part of methyl hydroxybenzoate, 1.6 parts of amino acid humectant, antioxygen
0.8 part of hyaluronic acid of 4 parts of agent and hydrolysis；
B, by the weighed deionized water of step A, myrrh extract, Olibanum extract, notopterygium root extract, extractive of pubescent angelica root coumarin,
Safflower extract, camphor, rhizoma cyperi seed extract are stirred mixing according to aforementioned proportion, and heating stirring is carried out under germ-free condition extremely
90 DEG C, constant temperature stirs 48min at a temperature of 85 DEG C, after making it dissolve uniformly, is cooled under normal temperature condition, obtains solution a；
C, propylene glycol weighed in step A, methyl hydroxybenzoate are stirred mixing, the temperature remains within the normal range, obtains solution b；
D, snail weighed in step A secretion filtrate, decoyl hydroximic acid, glycerol caprylate are stirred under aseptic conditions
Mixing is mixed, obtains solution c after mixing；
E, solution a, solution b and solution c are stirred mixing, under germ-free condition, after mixing evenly, filter out filter residue,
The reparation spray of the filtrate of secretion containing snail can be obtained.
In order to further test the reparation spray for the repairing effect of skin problem, by secreting containing snail for embodiment 3
The reparation spray of object filtrate carries out experiment detection, chooses 100 different sexes, has different degrees of skin pain, skin scabies
The problems such as itching is tested, and chooses other reagents with the same function and tests as a comparison, takes after the daily clean skin of experimenter
Appropriate amount of sample is applied to uncomfortable place, and twice for the morning and evening on the one, 30 days are a cycle, reparation of the invention to application method
Spray is improved just for uncomfortable phenomenon, the skin problem outside skin, is not particularly suited for the skin of wound, either
Open wound mouth, sensibility skin, pregnant woman's disabling.
Common store method is to be sealed after being finished every time, In Shade, avoids direct sunlight.
The reparation spray of the filtrate of secretion containing snail of the invention of table 1
The reparation spray of 2 like product of table
The effect of can be seen that the reparation spray containing snail secretion filtrate in the present invention from above data is on the whole
Better than the similar reparation spray of control, in skin redness, pruitus, skin pain, facial inflammation, uncomfortable phenomenon, use
Skin comfort etc. illustrates that the reparation spray has preferable repair to skin problem than the excellent effect of control group afterwards
Effect.
The effect of reparation spray in order to further illustrate the present invention, the reparation spray described in Examples 1 to 4 and comparison
Reparation spray prepared by Examples 1 to 4 without containing snail secretion filtrate compares；Specific experiment data such as 3 institute of table
Show；
Test object be 25~50 one full year of life women, 400 people, have the skin such as the baffled itch of cutaneous pain, skin, redness
Problem is divided into 8 groups, every group of 50 people at random；Product of the embodiment of the present invention is carried out to 8 groups of personnel respectively and comparative example produces
The comparison of product, spraying are paid a return visit and are recorded to personnel after two weeks；
3 embodiment of table and comparative example data
(note: the calculation method of skin improvement rate is by the way that skin after reparation spray will be used to restore normal in the present invention
Improve the ratio of the sum of obvious number with total number of persons with skin.)
It, can be with to the test data of embodiment using the preparation method of invention it can be seen from the test data of experiment of table 3
Find out, uses reparation spray of the invention that 95% or more can be made there are the skin such as redness, pain, baffled itch for skin
Problem makes moderate progress, and can see by the data in table, in comparative example, has lacked snail point in spray due to repairing
Secretion filtrate, the contained raw material for repairing skin function is reduced, so repair also reduces accordingly.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention, for this field skill
For art personnel, it is clear that invention is not limited to the details of the above exemplary embodiments, and without departing substantially from spirit of the invention or
In the case where essential characteristic, the present invention can be realized in other specific forms.Therefore, in all respects, should all incite somebody to action
Embodiment regards exemplary as, and is non-limiting, the scope of the present invention by appended claims rather than on state
Bright restriction, it is intended that including all changes that fall within the meaning and scope of the equivalent elements of the claims in the present invention
It is interior.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (10)
1. a kind of reparation spray of the filtrate of secretion containing snail, which is characterized in that the component for repairing spray contains deionization
Water, myrrh extract, Olibanum extract, notopterygium root extract, extractive of pubescent angelica root coumarin, safflower extract, camphor, rhizoma cyperi seed extract,
Decoyl hydroximic acid, propylene glycol, glycerol caprylate, methyl hydroxybenzoate, snail secretion filtrate, amino acid humectant, antioxidant and water
Solve hyaluronic acid.
2. reparation spray according to claim 1, which is characterized in that the component for repairing spray contains deionized water 25
~80,1~4 part of myrrh extract, 1~4 part of Olibanum extract, 2~8 parts of notopterygium root extract, 2~8 parts of extractive of pubescent angelica root coumarin, safflower
1~4 part of extract, 0.1~1 part of camphor, 2~8 parts of rhizoma cyperi seed extract, 0.02~0.4 part of decoyl hydroximic acid, propylene glycol 1~6
Part, 0.01~0.5 part of glycerol caprylate, 0.01~0.2 part of methyl hydroxybenzoate, snail secrete 2~5 parts of filtrate, amino acid humectant 1
0.5~1 part of hyaluronic acid of~2 parts, 3~5 parts of antioxidant and hydrolysis.
3. reparation spray according to claim 2, which is characterized in that the component for repairing spray contains deionized water 30
~60,2~3 parts of myrrh extract, 2~3 parts of Olibanum extract, 4~7 parts of notopterygium root extract, 4~7 parts of extractive of pubescent angelica root coumarin, safflower
2~3 parts of extract, 0.3~0.8 part of camphor, 4~7 parts of rhizoma cyperi seed extract, 0.04~0.3 part of decoyl hydroximic acid, propylene glycol 2
~5 parts, 0.05~0.3 part of glycerol caprylate, 0.05~0.15 part of methyl hydroxybenzoate, 3~5 parts of filtrate of snail secretion, amino acid guarantor
0.6~1 part of hyaluronic acid of 1.2~1.8 parts of humectant, 3~4 parts of antioxidant and hydrolysis.
4. reparation spray according to claim 3, which is characterized in that the component for repairing spray contains deionized water
50,2~2.5 parts of myrrh extract, 2~2.5 parts of Olibanum extract, 5 parts of notopterygium root extract, 5 parts of extractive of pubescent angelica root coumarin, safflower extract
2~3 parts of object, 0.4 part of camphor, 5 parts of rhizoma cyperi seed extract, 0.09 part of decoyl hydroximic acid, 0.15 part of glycerol caprylate, methyl hydroxybenzoate
0.1 part, 4 parts of filtrate of snail secretion, 5 parts of propylene glycol, 1.5 parts of amino acid humectant, 4 parts of antioxidant and hydrolysis hyaluronic acid
0.6 part.
5. reparation spray according to claims 1 to 4, which is characterized in that the antioxidant is hydroxy acetophenone.
6. reparation spray according to claims 1 to 5, which is characterized in that the preparation method of the myrrh extract: take end
Medicine, 60 DEG C of ethyl alcohol that the 75% of 12 times of volumes of myrrh weight is added extract 2 times, each 2h, combined extract, filtering, and concentration is dry
It is dry to get；
The preparation method of the notopterygium root extract: taking Rhizoma Et Radix Notopterygii, and the pure water of 5 times of volumes of Rhizoma Et Radix Notopterygii weight is added, and impregnates 1h and is steamed using water
4h is extracted in the distillation of steam distillation method, collects distillate, is added sodium chloride to being saturated, is collected volatile oil, obtain notopterygium root extract；
The preparation method of the Olibanum extract: taking olibanum, crushes, and the distilled water of 5 times of amounts is added, and 2h is boiled in heating, and cooling is simultaneously
Centrifugal filtering, filter residue heats again boils 0.5h, centrifugal filtering, and filter residue adds the ethyl alcohol that 1.5 times of amount concentration are 65%, refluxing extraction
4h, centrifugal filtering, 3 times repeatedly, ethyl alcohol is recovered under reduced pressure in merging filtrate, obtains extract；
The preparation method of the extractive of pubescent angelica root coumarin: taking Radix Angelicae Pubescentis, and the water that 8 times of weight are added impregnates 30min, is decocting 2h, is filtering, will
Filtrate concentration, spray drying；
The rhizoma cyperi seed extract: taking the rhizome of nutgrass flatsedge, handles clean rear crushing, carries out concentration extraction by centrifugal extractor.
7. a kind of preparation method of the reparation spray of filtrate of secretion containing snail, which comprises the steps of:
A, weigh respectively 25~80 parts of water, 1~4 part of myrrh extract, 1~4 part of Olibanum extract, 2~8 parts of notopterygium root extract,
2~8 parts of extractive of pubescent angelica root coumarin, 1~4 part of safflower extract, 0.1~1 part of camphor, 2~8 parts of rhizoma cyperi seed extract；Decoyl hydroximic acid
0.02~0.4 part, snail secretion 2~5 parts of filtrate, 1~6 part of propylene glycol, 0.01~0.5 part of glycerol caprylate, methyl hydroxybenzoate
0.5~1 part of hyaluronic acid of 0.01~0.2 part, 1~2 part of amino acid humectant, 3~5 parts of antioxidant and hydrolysis；
B, by the weighed water of step A, myrrh extract, Olibanum extract, notopterygium root extract, extractive of pubescent angelica root coumarin, safflower extract,
Camphor, rhizoma cyperi seed extract are proportionally stirred mixing, and heating stirring is carried out under germ-free condition, and constant temperature stirring keeps its molten
After solution is uniform, solution a is obtained；
C, propylene glycol weighed in step A, methyl hydroxybenzoate, amino acid humectant, antioxidant and hydrolysis hyaluronic acid are carried out
It is stirred, the temperature remains within the normal range, obtains solution b；
D, snail weighed in step A secretion filtrate, decoyl hydroximic acid, glycerol caprylate are stirred under aseptic conditions mixed
It closes, obtains solution c after mixing；
E, solution a, solution b and solution c are stirred mixing, under germ-free condition, after mixing evenly, can be obtained containing snail point
The reparation spray of secretion filtrate.
8. the preparation method according to claim 7 for repairing spray, which is characterized in that the heating temperature in the step B
It is 75~90 DEG C, constant temperature time is 20~50min.
9. the preparation method according to claim 7 for repairing spray, which is characterized in that solution a in the step E, molten
Liquid b and solution c are stirred between mixing, are cooled to room temperature.
10. the preparation method according to claim 7 for repairing spray, which is characterized in that solution a in the step E, molten
Liquid b and solution c is filtered after being stirred mixing.
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