KR20110049201A - The facewashing comestic composition and its extraction method improving etiology of acnegenic skin - Google Patents

Abstract

PURPOSE: A cleansing cosmetic composition for treating acne lesion is provided to ensure antibacterial action and to suppress propionibacteriium acnes proliferation. CONSTITUTION: A cleansing cosmetic composition for treating acne contains 3.0 weight% of Carthamus tinctorius (safflower) flower extract and 1.0-5.0 weight% of aroma essential oil. The aroma essential oil is tea tree, chamomile, lavender, and neroli. The cleansing cosmetic composition is used in the form of soap, cleansing foam, or mask pack. A method for extracting Carthamus tinctorius (safflower) flower comprises: a step of pulverizing dried Carthamus tinctorius (safflower) flower; a step of adding distilled water to the Carthamus tinctorius (safflower) flower and extracting; a step of decompressing to concentrate; and a step of freeze-drying.

Description

The facewashing comestic composition and its extraction method improving etiology of acnegenic skin}

The present invention relates to a face-wash cosmetic composition for improving acne skin lesions and a method of extracting the same, and in particular, propionibacterium acnes bacteria known as causative agents for further deepening acne skin conditions in adolescent adolescents. It is excellent in antimicrobial action that suppresses the proliferation of skin, and has excellent anti-inflammatory effect such as suppressing or alleviating inflammation when various skin troubles such as acne occur. Routeolin and acetin in the flavonoid compound components Has anti-inflammatory action and thus is useful for treating inflammation. As a solvent containing these ingredients, safflower extract (CARTHAMUS TINCTORIUS (SAFFLOWER) FLOWER EXTRACT),

Aroma Essential Oil, which helps to heal disease by bactericidal action (natural preservative), stimulating, nerve relaxation, hormone regulation, strengthening of natural immunity, and cell regeneration Tea tree (Meatree-Melaeuca alternifolia), chamomile (chamomile roman-Anthemis nobilis L), cedar (juniperus virginiana), lavender (Lavender-Lavenduia angustifolia), neroli (neroli-citrus auranthium) composition The present invention relates to a face-wash cosmetic composition and a method for extracting the same, thereby providing an effect on preventing acne or improving acne skin lesions.

Conventionally, as already known, active ingredients such as benzylperoxide, salicylic acid, erythromycin, clincher, salicylic acid, antibiotics, and other substances have the effect of inhibiting or removing propionibacterium acnes, In the case of mild acne, salicylic acid normally regulates keratinization of the skin, opening up clogged hair follicles and maintaining skin physiological function smoothly. It also removes, but in the gel type, it is difficult to absorb the skin, and various types of cleanser products may worsen acne.

The benzyl peroxide has the effect of removing propionibacterium acinis, but it takes at least two weeks before the effect is necessary and requires continuous treatment and affects sebum production or skin cell detachment of the hair follicle wall. It has been pointed out that the problem that acne is regenerating at the time of interruption due to lack of it.

In addition, the salicylic acid is used to prevent the drop of the skin cells to help maintain the skin cell dropout cycle is used, but it does not affect sebum production or propionibacterium acne bacteria, acne can be regenerated when stopped In the case of antibiotics, there is a high risk of side effects, and it has been a problem that does not affect other acne causes such as sebum production or skin cell detachment in hair follicles other than the removal of Propionibacterium acinis,

Other treatments include direct injections and various methods such as using a cotton extractor to remove the scalp or removing the scalp after laser treatment, but acne is not appropriate unless it is treated by a trained professional. Due to the treatment has spread the acne inflammation to the surrounding skin tissue has a problem that aggravates acne or leave acne scars.

The present invention is to provide an extraction technique that can be used as a cosmetic formulation by forming a face-wash cosmetic composition that can improve acne skin lesions to solve the above problems, and extract the main active ingredient It is an object of the invention.

Therefore, as a result of research, it has excellent antibacterial activity against propionibacterium acnes, which acts as a causative agent of acne skin lesions, and finds natural ingredients with excellent skin safety without problems even after long-term use. The purpose of the present invention is to provide a technique for extracting from dried safflower and an optimal composition containing the same, thereby providing a treatment in a stabilized state without causing side effects that occur during acne skin treatment.

In general, acne skin, which occurs mainly in puberty, is a skin lesion caused by active sebaceous glands around the hair follicles. In normal skin physiological function, the acne skin rises upward along the hair follicle wall and is discharged out through the skin. Sebum is not mixed with waste and can't be discharged and buried inside the hair follicles, causing convex elevations. Therefore, acne mainly occurs in the area of the face, scalp, neck, chest where the sebaceous glands are gathered. In general, Koreans are known to have acne lesions on their faces in puberty, regardless of gender.

It usually lasts more than 4-5 years, and then over 20s, the lesions gradually disappear. In women, hormonal balance changes during menstrual cycles, which can lead to significant changes in acne lesions.

In normal skin physiology, dead cells in the hair follicles cause keratinization, which in turn is discharged to the skin surface, but in puberty acne skin, the keratinization of these cells progresses rapidly and does not come out. This will create a good environment for bacteria to grow.

In particular, the propionibacterium acnes acne bacteria on the surface of the face are the source of acne lesions by breeding with sebum as nutrients.In normal skin, the bacteria are distributed in the right amount and do not cause any problems, but hair follicles do not cause any problems. When the sebum accumulates in the hair follicles, the sebum is eaten and multiplies rapidly, and it is mixed with the waste products generated and discharged in the metabolism process, causing secondary inflammation to the hair follicles and acne skin.

 The present invention is to solve the above problems in acne skin improvement to remove the cause of the occurrence of acne such as excessive sebum secretion, abnormal keratinization of skin cells in the hair follicles, propionibacterium acnes bacteria It has excellent antibacterial activity against propionibacterium acne, which is the cause of acne skin lesions, and it is extracted and extracted from CARTHAMUS TINCTORIUS (SAFFLOWER) FLOWER which is a high safety material even for long-term use. It is composed of 1% by weight to 10.0% by weight, and aroma essential oils (tea tree, chamomile, cedar, lavender, neroli, etc.) are mixed at 1.0% by weight to 8.0% by weight, respectively. It is achieved by improving stably.

Safflower extract (CARTHAMUS TINCTORIUS (SAFFLOWER) FLOWER EXTRACT) according to the configuration of the present invention and the safflower cosmetic composition containing safflower extract and aromatic essential oil safflower extract (CARTHAMUS) showing an excellent effect on the improvement of acne skin lesions TINCTORIUS (SAFFLOWER) FLOWER EXTRACT) Provides a method for easily purifying active ingredients, and it is excellent in improving acne skin lesions by prescribing these extracts at a certain ratio. In addition, it activates the hair follicle cells of the skin to help metabolism and restore the keratinization of the skin to normal skin physiological function.

Safflower has been called ‘safflower’ for the sake of 'helping people's health' and has been introduced as safflower since the petals are red. Since ancient times, safflower has been used as a material for dyes and rouges that apply natural pigments to fabrics by compressing petals and then using purified pigments. It is native to Egypt and grows as a seed after flowering as an annual herb. Safflower can be seeded and fruit and seeds in 3-4 months.

In botanical terms, safflower is classified as a medicinal plant. The name of the plant is safflower (Asteraceae, Composicae), and the name of the herb is known as safflower (Safflower), safflower (seed) and the scientific name is Carthamus tinctorius L.

The active ingredient of the seed is linoleic acid, which has the effect of purifying cholesterol in the blood vessels through metabolism and is known to be effective in improving arteriosclerosis. One of the symptoms of arteriosclerosis, an adult disease, is to squeeze a handful of dried flowers or seeds together and pour a cup of hot water to drink.

One teabag at a time, two to three times a day drinking is very effective. Alternatively, lightly fry the seed, dissolve it in water, and drink it. Flowers have been used as red dyes in the manufacture of traditional costumes, such as hanbok, and used as natural colorants in lips and foods.

Safflower is classified as a herbal medicine because it is particularly effective in crushing broken bones and menstrual cramps.

The present invention has excellent antimicrobial activity against propionibacterium acnes, which is a cause of acne skin lesions, and extracted from safflower (CARTHAMUS TINCTORIUS (SAFFLOWER) FLOWER), which is a highly safe substance even after long-term use. By using, the extract is composed of 1.0% by weight to 10.0% by weight, and aroma essential oils (tea tree, chamomile, cedar, lavender, neroli, etc.) are each mixed by 1.0% by weight to 8.0% by weight of acne It is characterized by providing a facial cleansing composition and a method of extracting the same having a significant effect in improving lesions of the skin.

The aromatic essential oils are very diverse as follows.

Peppermint, clary sage, cypress, eucalyptus, fennel, geranium, grapefruit, juniper berry, lavender, lemon, lemongrass, orange sweet, partooli, pine, rosemary, sandalwood, thyme, ylang-ylang, rosewood, burger nail You will be choosing rose, jasmine, basil, black pepper, mir, frankin sense, palmarosa, hyssop, ginger, sandalwood, marjoram, mandarin, tea tree, neroli, cedarwood, lavender and carbomile among others. The features are as follows.

Teatree (Meatree-Melaeuca alternifolia) controls excessive excitement and is effective against flu and other viral infections. It is used for acne, dandruff, gingivitis, oralitis, dermatitis and rashes.

Neroli-citrus auranthium is a comfort to chronic anxiety, soothes the cardiovascular system such as hypertension, and is excellent for skin cell regeneration. It is used for aging skin, depression, stress, menstrual pain relief, stretch marks and skin elasticity improvement.

Virginia cedarwood (juniperus virginiana) is effective for chronic bronchial disorders and the main ingredient is cedrol (31%), which is one of the alcoholic components, which is effective for anti-inflammatory, repellent, and antibacterial agents, helps oily skin and scalp tonic and relaxes. It is useful for relaxing and meditating.

Lavender (Lavender-Lavenduia angustifolia) is the most widely used essential oil and its effects are varied and its soothing and relaxing effects are suitable for insomnia or anxiety.

Chamomile roman (chamomile roman-Anthemis nobilis L) has a sedative effect and is effective in relieving pain such as arthritis and coping with physiological disorders. Effective for sensitive, dry skin and allergic skin.

The safflower extract of the cleansing cosmetic composition effective in improving acne skin lesions according to the present invention (CARTHAMUS TINCTORIUS (SAFFLOWER) FLOWER EXTRACT) is in the range of 1.0 wt% to 10.0 wt%, but preferably 3.0 wt% ~ 8.0% by weight.

If the content is less than 3.0% by weight, the antimicrobial activity against propionibacterium acnes may be somewhat weakened. If more than 10.0% by weight, the liquid stability of the composition may occur.

In addition, aroma essential oils (tea tree, chamomile, cedar, lavender, neroli, etc.) are recommended to be prescribed in each of five oils in the ratio of 1.0% to 5.0% by weight, but more than 5.0% by weight may cause side effects on the skin. There is this.

In addition, it is also possible to prescribe with antibacterial agents such as benzoyl peroxide, tetracycline, erythromycin, triclosan, androgens, steroids, etc., which have been used in conventional acne treatments.

The active ingredient of the safflower flower of the present invention generally uses purified water as a solvent, and can be extracted by the following method.

a) Crush the dried safflower (CARTHAMUS TINCTORIUS (SAFFLOWER) FLOWER)

b) After extracting the crushed safflower flower (CARTHAMUS TINCTORIUS (SAFFLOWER) FLOWER) with purified water as a solvent for 4 hours using a reflux cooling device

c) filtering the extract concentrate;

d) distilling the concentrate under reduced pressure to reconcentrate;

e) final extraction of the active ingredient of safflower flower, characterized in that the concentrated residue is freeze-dried to form a powder again.

Safflower extract of the present invention (CARTHAMUS TINCTORIUS (SAFFLOWER) FLOWER EXTRACT) has an excellent antimicrobial effect against propionibacterium acnes (appionibacterium acnes) has a significant effect when applied to acne skin, especially papules appearing in acne skin Inflammation symptoms such as pustules and nodules have also been shown to improve.

Example 1

Extraction method of active ingredient of dried safflower flower

20 g of dried safflower flower was added to 2000 ml of purified water, and a reflux condenser was attached at 95 ° C. for 4 hours. The solid content was 0.4Brix and 1900 ml was extracted, filtered and concentrated under reduced pressure at 60 ° C to 24 Brix, followed by freeze drying. It was.

Example 2

Table 1 shows the optimum composition of the acne soap in the face wash containing the safflower extract extracted according to Example 1.

Prototype Manufacturing Prescription of Acne Soap

The Ingredients Analysis of beauty soap No. INCI Name % One palm oil 24.000 2 macadamianut oil 4.000 3 coconut oil 24.000 4 eveningprimerose oil 4.000 5 Sweet almond oil 4.000 6 calendula oil A reasonable amount 7 jojoba oil 4.000 8 glycerin 0.020 9 butylene glycol 0.150 10 propylene glycol 2.000 11 sodium hyaluronate 5.000 12 chamomilla recutitaflower extract 5.000 13 Safflower Extract 6.000 14 Lavender oil A reasonable amount 15 Tea tree oil 4.500 16 german chamomile 5.000 TOTAL 100.000

Test Example 1

Measurement and Evaluation of Antimicrobial Activity against Acne Bacteria

Principle of Evaluation

Table 2 shows the antimicrobial activity of P. acnes and P. ovale by DDT by 0.1%, 1%, 5% and 10%, respectively. As set out above, the test substance IUK was beginning to show an antimicrobial effect on P. acnes, from a concentration of 1% with respect to the time after treatment at a concentration of 1-10%, P. acnes.

Table 2. DDT  ( Disk Diffusion Test )On by Safflower extract  Antibacterial activity ( Transparent  Size, mm)

P. acnes PC ^a 0.002% 30
Safflower Extract 10% 19 5% 17 One% 12 0.1% NE

^a PC: Positive control ( P. acnes : 0.002% Erythromycin,), disc diameter 10 mm

Test Example 2

Clinical evaluation of the improvement effect of acne skin lesions

In order to perform a clinical evaluation of the improvement of acne skin lesions of the composition containing safflower extract and aroma essential oil according to the present invention, a face wash cosmetic acne soap prototype containing these as main ingredients is used for 20-40s. Was used twice a day for men and women for 2 months and then compared with the photographing and subject's questionnaire to determine the improvement of skin condition.

NO gender age
(three) acne
Occurrence period (year) Period of use
(month)  Skin side effects Clinical result (% improvement) One south 20 6 2 radish 80% 2 south 20 5 2 radish 90% 3 south 20 5 2 radish 70% 4 south 20 4 2 radish 80% 5 south 20 4 2 radish 50% 6 south 20 6 2 radish 90% 7 female 20 One 2 radish 60% 8 south 20 One 2 radish 50% 9 female 20 One 2 radish 60% 10 female 20 10 2 radish 80% 11 south 23 One 2 radish 90% 12 female 20 One 2 radish 90% 13 south 49 One 2 radish 90% 14 female 49 One 2 radish 80% 15 female 48 One 2 radish 90% 16 south 20 4 2 radish 70% 17 south 20 3 2 radish 80%

As shown in the clinical results of Table 3, 3 out of 17 subjects (18%) did not show a significant improvement, but the remaining 14 (82%) showed a clear improvement of more than 70%. In addition, none of the subjects complained of adverse effects such as skin rashes during the use period.

Claims (5)

In improving acne skin lesions, acne skin improvement facial cleansing composition and its extracting method, characterized in that aromatherapy essential oil (tea tree, chamomile, cedar, lavender, neroli, etc.) is mixed with safflower extract. According to claim 1, Safflower extract 3.0% by weight to 8.0% by weight, Aroma essential oil facial cleansing cosmetic composition and method for extracting acne skin lesions characterized in that the composition is composed of 1.0% by weight to 5.0% by weight. The composition according to claim 1 or 2, wherein the face-wash cosmetic composition is a cosmetic formulation into a soap, a cleaning foam, a mask pack and a method of extracting the same. The safflower extract according to claim 1, wherein the safflower extract is a step of pulverizing dried safflower, extracting the pulverized safflower for 4 hours using purified water, which is an extraction solvent, using a reflux cooling device, and filtering the extract concentrate. Facial cleansing cosmetic composition for improving acne skin lesions, characterized in that for extracting a safflower extract comprising the step of, distilling under reduced pressure to extract the concentrated solution, and freezing and drying the concentrated residue to powder again And extraction method thereof. The cleansing cosmetic composition for improving acne skin lesions and extracting method according to claim 4, wherein the extraction solvent is selected from at least one solvent from purified water, ethanol, methanol, and propanol.