CN111000871A - Oral cavity spray and preparation method thereof - Google Patents
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A61K9/00—Medicinal preparations characterised by special physical form
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Abstract
The invention discloses an oral spray which comprises the following components in parts by weight: 5-10 parts of an antiallergic agent; 65-10 parts of vitamin B; 5-10 parts of a humectant; 1-3 parts of a bactericide; 5-10 parts of a pH regulator; 1-5 parts of wetting agent and solubilizer; 2-5 parts of a flavoring agent; 5-10 parts of a mucosa repairing agent. Compared with the prior art, the invention has the advantages that: the oral spray has outstanding effects in the aspects of treating oral ulcer, oral bacteriostasis, stomatitis, gingival bleeding and the like. The preparation method comprises the following steps: the method comprises the following steps: firstly measuring 2000ml of physiological saline; step two: sequentially putting the components of the formula into a stirrer at the rotating speed of 300rpm/min, and uniformly stirring until the components are completely dissolved; step three: and after observing complete dissolution, reducing the rotating speed to 60rpm/min, and stirring until no bubbles exist, thus obtaining the oral spray. The hydrolyzed animal placenta (pig) extract of the present invention has unique regeneration characteristics, and has unique advantages in stem cell delivery, tissue engineering, wound healing and inflammation prevention compared with other decellularized tissues.
Description
Technical Field
The invention relates to a spray, in particular to an oral spray and a preparation method thereof.
Background
In other words, "the disease enters from the mouth", and the oral cavity of a human body becomes a hotbed for the reproduction of a plurality of bacteria such as streptococcus, staphylococcus and the like due to the breathing and the residue of chewing food, so that various diseases such as oral ulcer, decayed tooth, sphagitis, upper respiratory tract infection and the like are easily caused, and the health of people is seriously influenced. Particularly, people live in the environment with fast pace, high mental stress and high working pressure for a long time at present, and are easy to cause excessive thinking, anxiety and unbalance of the heart, which causes the dysfunction of the spleen and the stomach and the pyretic pulmonary stomach. The population suffers from halitosis, ulcer, dry throat, toothache and other symptoms for a long time and at different degrees every year, and the oral cavity is affected and sometimes damaged in the process of radiotherapy or chemotherapy of part of the tumor in the oral cavity. The halitosis brings discomfort and pain to the people, such as middle-aged people, high-end business people, and professional groups needing face-to-face communication. Therefore, with the increase of social activities of modern people, more attention is paid to oral breath, and oral hygiene becomes an important door for preventing and treating diseases. At present, oral medicines are mostly adopted to treat oral inflammation or ulcer, the effect is slow, the pain of a patient cannot be quickly eliminated, the medicines generally have side effects, and a large amount of oral medicines can invisibly damage the body and are not beneficial to the health of the human body. The oral spray is rare, can make the medicine directly and effectively contact the upper respiratory tract, has good medicinal effect, has the advantages of convenient carrying, simple and quick taking and the like, and is popular with patients and consumers.
Canker sores develop as a result of a combination of factors including local trauma, radiation therapy and chemotherapy of disease, stress, food, medication, malnutrition, altered hormone levels and vitamin or trace element deficiencies. Systemic diseases, heredity, immunity and microorganisms may play an important role in the development and development of oral ulcers. Such as lack of trace elements of zinc and iron, lack of folic acid, vitamin B12, malnutrition and the like, can reduce the immune function and increase the possibility of oral ulcer; bacteria such as streptococcus sanguis and helicobacter pylori are closely related to dental ulcer. Oral ulcers generally indicate potential systemic disease conditions in the body, and oral ulcers are associated with gastric ulcers, duodenal ulcers, ulcerative colitis, Crohn's disease, hepatitis, female menstrual periods, vitamin B malabsorption, vegetative nerve dysfunction, and the like. In summary, there is a need for a product that addresses both the symptoms and root causes, avoids recurrent oral ulcer attacks, and has no side effects. The oral spray is a medicament and oral product preparation which develops rapidly in recent years, has the characteristics of convenience, rapidness and quick response, and is generally applied to lung absorption of medicaments or oral cleaning. But no oral spray for treating oral ulcer, inhibiting oral bacteria and preventing oral inflammation is available at present.
Disclosure of Invention
The invention aims to solve the defects and provides an oral cavity spray and a preparation method thereof.
The above object of the present invention is achieved by the following technical means: an oral spray comprises the following components in parts by weight: 5-10 parts of an antiallergic agent; 65-10 parts of vitamin B; 5-10 parts of a humectant; 1-3 parts of a bactericide; 5-10 parts of a pH regulator; 1-5 parts of wetting agent and solubilizer; 2-5 parts of a flavoring agent; 5-10 parts of a mucosa repairing agent.
Preferably, the oral spray consists of the following components in parts by weight: 6-9 parts of an antiallergic agent; 66-9 parts of vitamin B; 6-9 parts of a humectant; 2-3 parts of a bactericide; 6-9 parts of a pH regulator; 2-4 parts of wetting agent and solubilizer; 3-4 parts of a flavoring agent; 6-9 parts of a mucosa repairing agent.
Preferably, the oral spray consists of the following components in parts by weight: 8 parts of an antiallergic agent; 68 parts of vitamin B; 8 parts of a humectant; 2 parts of a bactericide; 8 parts of a pH regulator; 3 parts of wetting agent and solubilizer; 3 parts of a flavoring agent; 8 parts of a mucosa repair agent.
Preferably, the humectant is betaine, also known as trimethylglycine, which is an entirely naturally edible amino acid. Betaine is an alkaline substance with strong hygroscopic properties and is therefore often treated with anti-caking agents during the manufacturing process. Modern researches show that the betaine has the capability of rapidly improving the moisture retention of skin and has unique performance of protecting cell membranes by a humectant, the moisturizing mechanism performance of the betaine is superior to that of other humectants, the betaine can keep moisture for a long time even under low concentration, and the moisturizing effect of the betaine is to allow water molecules to be completely absorbed and utilized by living cells. When one water molecule occupies the middle of the betaine zwitterion, the water molecule can be easily released to the peripheral liquid, so that the moisturizing effect is realized. Protective cell performance effects of betaine: when the skin is subjected to high osmotic pressure of the external environment, a large amount of cell osmolytes can be lost, so that the apoptosis is caused. Betaine osmolytes inhibit this process and penetrate through the stratum corneum of the skin to protect the cellular balance. Betaine can promote regeneration and metabolism of human tissue cells, accelerate wound healing, prevent scar formation, and has strong antiinflammatory and antiviral effects, and can accelerate ulcer healing and relieve pain.
Preferably, the antiallergic agent is dipotassium glycyrrhizinate which is a potassium glycyrrhizinate salt extracted from liquorice, the dipotassium glycyrrhizinate is a glycyrrhizic acid derivative and has the effects of resisting inflammation, allergy and ulcer, promoting regeneration of epithelial cell tissues and the like, and dipotassium glycyrrhizinate and glycyrrhetinic acid products are used as antiallergic components in cosmetics and anti-inflammatory and antiallergic medicines at present, and the effect is very obvious through practice. Similarly, many people with oral and gingival allergy have great need for an oral spray which can effectively resist allergy and has no adverse reaction and dependence. Oral diseases have a high incidence and are increasingly being noticed. It is also believed that prevention is more important than treatment for oral diseases, and thus an oral spray that is anti-inflammatory, anti-allergic, and can prevent and alleviate various oral disorders would be welcomed by many people.
Preferably, the bactericide is chlorhexidine which is also called chlorhexidine and has the chemical name of chlorhexidine, is the chlorhexidine cationic surfactant, has quite strong broad-spectrum antibacterial and bactericidal effects, is a better bactericidal disinfectant, and has stronger antibacterial effects on gram positive bacteria and gram negative bacteria than benzalkonium bromide. The oral cavity gargling liquid is positively charged, is adsorbed on plaque with negative charge and the surface of oral mucosa when the oral cavity gargling liquid is used for gargling, then adsorbed medicines are dispersed from the parts and gradually separated out to generate a continuous effect, the concentration of the medicine in saliva is reduced after 24 hours, the oral cavity gargling liquid is adsorbed on a permeation barrier of a bacterial cell serosa, so that cell contents leak out, and the oral cavity gargling liquid has a bacteriostatic effect at low concentration and a bactericidal effect at high concentration. Even in the presence of serum, blood, etc. Is not effective on spore, acid-fast bacillus, fungus and virus. The low concentration has the function of bacteriostasis, and the high concentration has the function of sterilization. The dental plaque and the oral mucosa surface with negative charges can be adsorbed by self positive charges and are combined with bacterial cell membranes through the parts in a dispersing way, so that the permeability of the cell membranes is changed, the leakage of cell contents is promoted, and the efficient antibacterial effect is finally achieved; thereby relieving various discomforts caused by the oral ulcer to a certain extent and accelerating the healing of the oral ulcer surface.
Preferably, the pH regulator is sodium malate.
Preferably, the flavoring agent is blueberry essence, and the blueberry essence is one of the flavoring agents and is one of the essences. Has strong and pure blueberry fragrance, has lasting fragrance, and improves the taste of the oral spray.
Preferably, the mucosa repair agent is a hydrolyzed animal placenta extract, wherein the hydrolyzed animal placenta extract contains collagen, amino acids, polypeptides, polysaccharides, etc., and can participate in tissue repair.
Preferably, the hydrolyzed animal placenta extract is a hydrolyzed placenta extract of swine.
Preferably, the wetting agent and the solubilizer are propylene glycol, and the propylene glycol has the characteristics of a fat-soluble solvent, is very high in permeability and high in dissolving power and is beneficial to dissolving other materials.
Preferably, the vitamin B6 can normalize the protein and amino acid metabolism of the skin; regulating the activity of sebaceous glands.
The preparation method of the oral spray comprises the following steps:
the method comprises the following steps: firstly measuring 2000ml of physiological saline;
step two: sequentially putting 5-10 parts of antiallergic agent, 5-10 parts of vitamin B65, 5-10 parts of humectant, 1-3 parts of bactericide, 5-10 parts of pH regulator, 1-5 parts of wetting agent and solubilizer, 2-5 parts of flavoring agent and 5-10 parts of mucosa repair agent into a stirrer at the rotating speed of 300rpm/min, and uniformly stirring until the components are completely dissolved;
step three: and after observing complete dissolution, reducing the rotating speed to 60rpm/min, and stirring until no bubbles exist, thus obtaining the oral spray.
Compared with the prior art, the invention has the advantages that: the oral spray has outstanding effects in the aspects of treating oral ulcer, oral bacteriostasis, stomatitis, gingival bleeding and the like. The hydrolyzed animal placenta (pig) extract of the present invention has unique regeneration characteristics, and has unique advantages in stem cell delivery, tissue engineering, wound healing and inflammation prevention compared with other decellularized tissues.
Detailed Description
The present invention will be described in more detail with reference to examples.
Example 1: the invention relates to an oral spray, which comprises the following components in parts by weight: 5 parts of an antiallergic agent; 610 parts of vitamin B; 5 parts of a humectant; 3 parts of a bactericide; 5 parts of a pH regulator; 5 parts of wetting agent and solubilizer; 2 parts of a flavoring agent; 10 parts of mucosa repair agent. The preparation method of the oral spray comprises the following steps: the method comprises the following steps: firstly measuring 2000ml of physiological saline; step two: sequentially adding 5 parts of an antiallergic agent; 610 parts of vitamin B; 5 parts of a humectant; 3 parts of a bactericide; 5 parts of a pH regulator; 5 parts of wetting agent and solubilizer; 2 parts of a flavoring agent; 10 parts of mucosa repairing agent is put into a stirrer, and the rotating speed is 300rpm/min, so that the mucosa repairing agent is uniformly stirred until the mucosa repairing agent is completely dissolved; step three: and after observing complete dissolution, reducing the rotating speed to 60rpm/min, and stirring until no bubbles exist, thus obtaining the oral spray.
Example 2: an oral spray comprises the following components in parts by weight: 8 parts of an antiallergic agent; 68 parts of vitamin B; 8 parts of a humectant; 2 parts of a bactericide; 8 parts of a pH regulator; 3 parts of wetting agent and solubilizer; 3 parts of a flavoring agent; 8 parts of a mucosa repair agent. The preparation method of the oral spray comprises the following steps: the method comprises the following steps: firstly measuring 2000ml of physiological saline; step two: sequentially adding 8 parts of an antiallergic agent; 68 parts of vitamin B; 8 parts of a humectant; 2 parts of a bactericide; 8 parts of a pH regulator; 3 parts of wetting agent and solubilizer; 3 parts of a flavoring agent; putting 8 parts of the mucosa repairing agent into a stirrer at the rotating speed of 300rpm/min, and uniformly stirring until the mucosa repairing agent is completely dissolved; step three: and after observing complete dissolution, reducing the rotating speed to 60rpm/min, and stirring until no bubbles exist, thus obtaining the oral spray.
Example 3: an oral spray comprises the following components in parts by weight: 10 parts of an antiallergic agent; 65 parts of vitamin B; 10 parts of a humectant; 1 part of a bactericide; 10 parts of a pH regulator; 1 part of wetting agent and solubilizer; 5 parts of a flavoring agent; 5 parts of mucosa repair agent. The preparation method of the oral spray comprises the following steps: the method comprises the following steps: firstly measuring 2000ml of physiological saline; step two: sequentially adding 10 parts of an antiallergic agent; 65 parts of vitamin B; 10 parts of a humectant; 1 part of a bactericide; 10 parts of a pH regulator; 1 part of wetting agent and solubilizer; 5 parts of a flavoring agent; 5 parts of mucosa repairing agent is put into a stirrer, and the rotating speed is 300rpm/min, so that the mucosa repairing agent is uniformly stirred until the mucosa repairing agent is completely dissolved; step three: and after observing complete dissolution, reducing the rotating speed to 60rpm/min, and stirring until no bubbles exist, thus obtaining the oral spray.
In each embodiment, preferably, the humectant is betaine, also known as trimethylglycine, which is an entirely naturally edible amino acid. Betaine is an alkaline substance with strong hygroscopic properties and is therefore often treated with anti-caking agents during the manufacturing process. Modern researches show that the betaine has the capability of rapidly improving the moisture retention of skin and has unique performance of protecting cell membranes by a humectant, the moisturizing mechanism performance of the betaine is superior to that of other humectants, the betaine can keep moisture for a long time even under low concentration, and the moisturizing effect of the betaine is to allow water molecules to be completely absorbed and utilized by living cells. When one water molecule occupies the middle of the betaine zwitterion, the water molecule can be easily released to the peripheral liquid, so that the moisturizing effect is realized. Protective cell performance effects of betaine: when the skin is subjected to high osmotic pressure of the external environment, a large amount of cell osmolytes can be lost, so that the apoptosis is caused. Betaine osmolytes inhibit this process and penetrate through the stratum corneum of the skin to protect the cellular balance. Betaine can promote regeneration and metabolism of human tissue cells, accelerate wound healing, prevent scar formation, and has strong antiinflammatory and antiviral effects, and can accelerate ulcer healing and relieve pain.
In each embodiment, preferably, the antiallergic agent is dipotassium glycyrrhizinate, the dipotassium glycyrrhizinate is a potassium glycyrrhizinate salt extracted from liquorice, the dipotassium glycyrrhizinate is a glycyrrhizic acid derivative and has the effects of resisting inflammation, resisting allergy, resisting ulcer, promoting regeneration of epithelial cell tissues and the like, and dipotassium glycyrrhizinate and glycyrrhetinic acid products are currently used as antiallergic components in cosmetics and anti-inflammatory and antiallergic medicines, and the effect is very obvious through practice. Similarly, many people with oral and gingival allergy have great need for an oral spray which can effectively resist allergy and has no adverse reaction and dependence. Oral diseases have a high incidence and are increasingly being noticed. It is also believed that prevention is more important than treatment for oral diseases, and thus an oral spray that is anti-inflammatory, anti-allergic, and can prevent and alleviate various oral disorders would be welcomed by many people.
In each embodiment, preferably, the bactericide is chlorhexidine, which is also called chlorhexidine, and has a chemical name of chlorhexidine, is a cationic surfactant, has quite strong broad-spectrum antibacterial and bactericidal effects, is a better bactericidal disinfectant, and has stronger antibacterial effects on gram-positive and gram-negative bacteria than benzalkonium bromide. The oral cavity gargling liquid is positively charged, is adsorbed on plaque with negative charge and the surface of oral mucosa when the oral cavity gargling liquid is used for gargling, then adsorbed medicines are dispersed from the parts and gradually separated out to generate a continuous effect, the concentration of the medicine in saliva is reduced after 24 hours, the oral cavity gargling liquid is adsorbed on a permeation barrier of a bacterial cell serosa, so that cell contents leak out, and the oral cavity gargling liquid has a bacteriostatic effect at low concentration and a bactericidal effect at high concentration. Even in the presence of serum, blood, etc. Is not effective on spore, acid-fast bacillus, fungus and virus. The low concentration has the function of bacteriostasis, and the high concentration has the function of sterilization. The dental plaque and the oral mucosa surface with negative charges can be adsorbed by the positive charges of the dental plaque and the oral mucosa surface, and are combined with the bacterial cell membrane through the parts in a dispersing way, so that the permeability of the cell membrane is changed, the leakage of cell contents is promoted, and the efficient antibacterial effect is finally achieved; thereby relieving various discomforts caused by the oral ulcer to a certain extent and accelerating the healing of the oral ulcer surface.
In each embodiment, preferably, the pH regulator is sodium malate.
In each embodiment, preferably, the flavoring agent is blueberry essence, and the blueberry essence is one of flavoring agents and one of essences. Has strong and pure blueberry fragrance, has lasting fragrance, and improves the taste of the oral spray.
In each embodiment, preferably, the mucosa repair agent is a hydrolyzed animal placenta extract, wherein the hydrolyzed animal placenta extract contains collagen, amino acids, polypeptides, polysaccharides, and the like, and can participate in tissue repair.
In various embodiments, preferably, the hydrolyzed animal placenta extract is a hydrolyzed placenta extract of swine.
In each embodiment, preferably, the wetting agent and the solubilizer are propylene glycol, and propylene glycol has the characteristics of a fat-soluble solvent, and has strong permeability and high dissolving power, so that the dissolution of other materials is facilitated.
In various embodiments, preferably, the vitamin B6 can normalize the protein and amino acid metabolism of the skin; regulating the activity of sebaceous glands.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes performed by the present invention or directly or indirectly applied to other related technical fields are included in the scope of the present invention.
Claims (10)
1. An oral spray, characterized in that: the composition consists of the following components in parts by weight: 5-10 parts of an antiallergic agent; 65-10 parts of vitamin B; 5-10 parts of a humectant; 1-3 parts of a bactericide; 5-10 parts of a pH regulator; 1-5 parts of wetting agent and solubilizer; 2-5 parts of a flavoring agent; 5-10 parts of a mucosa repairing agent.
2. The oral spray of claim 1, wherein: the humectant is betaine.
3. The oral spray according to claim 1, wherein the antiallergic agent is dipotassium glycyrrhizinate.
4. The oral spray of claim 1, wherein the bactericidal agent is chlorhexidine.
5. The oral spray of claim 1, wherein the flavoring agent is a blueberry flavor.
6. The oral spray of claim 1, wherein: the pH regulator is sodium malate.
7. The oral spray of claim 1, wherein: the wetting and solubilizing agents are propylene glycol.
8. The oral spray of claim 1, wherein: the hydrolyzed animal placenta extract is a mucosa repairing agent.
9. The oral spray of claim 8, wherein: the hydrolyzed animal placenta extract is hydrolyzed placenta extract of pig.
10. A preparation method of an oral spray is characterized by comprising the following steps: the method comprises the following steps:
the method comprises the following steps: firstly measuring 2000ml of physiological saline;
step two: sequentially putting 5-10 parts of antiallergic agent, 5-10 parts of vitamin B65, 5-10 parts of humectant, 1-3 parts of bactericide, 5-10 parts of pH regulator, 1-5 parts of wetting agent and solubilizer, 2-5 parts of flavoring agent and 5-10 parts of mucosa repair agent into a stirrer at the rotating speed of 300rpm/min, and uniformly stirring until the components are completely dissolved;
step three: and after observing complete dissolution, reducing the rotating speed to 60rpm/min, and stirring until no bubbles exist, thus obtaining the oral spray.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010056374.0A CN111000871A (en) | 2020-01-18 | 2020-01-18 | Oral cavity spray and preparation method thereof |
| EP20879268.9A EP4048298A4 (en) | 2019-10-24 | 2020-10-26 | Preparation and use of therapeutic hydrogels |
| PCT/US2020/057431 WO2021081540A1 (en) | 2019-10-24 | 2020-10-26 | Preparation and use of therapeutic hydrogels |
| US17/727,804 US20220249550A1 (en) | 2019-10-24 | 2022-04-24 | Preparation and use of tissue matrix derived powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010056374.0A CN111000871A (en) | 2020-01-18 | 2020-01-18 | Oral cavity spray and preparation method thereof |
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| CN111000871A true CN111000871A (en) | 2020-04-14 |
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| CN202010056374.0A Pending CN111000871A (en) | 2019-10-24 | 2020-01-18 | Oral cavity spray and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494223A (en) * | 2020-04-22 | 2020-08-07 | 福建汉氏联合干细胞科技有限公司 | Placenta-derived stem cell mouth-rinsing repair liquid |
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