CN105983131A - Hydrogel collagen dressing especially suitable for oily skins - Google Patents
Hydrogel collagen dressing especially suitable for oily skins Download PDFInfo
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- CN105983131A CN105983131A CN201510080027.0A CN201510080027A CN105983131A CN 105983131 A CN105983131 A CN 105983131A CN 201510080027 A CN201510080027 A CN 201510080027A CN 105983131 A CN105983131 A CN 105983131A
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- collagen protein
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Abstract
The invention relates to the field of medical/beauty treatment apparatuses, and concretely relates to a hydrogel collagen dressing especially suitable for oily skins. The collagen dressing comprises water, and collagens and macromolecular polymers distributed in water. The dressing can promote rapid transdermal absorption of collagens, so the dressing is suitable for being used as a medical/beauty treatment collagen dressing, and can be used in the field of medical treatment or medical science beauty treatment.
Description
Technical field
The present invention relates to collagen protein dressing, be specifically related to aquogel type collagen protein dressing, belong to beauty treatment
/ medical instruments field.
Background technology
Collagen protein, also known as collagen, is the key protein component of the connective tissue supporting and protecting body,
Also being a lot of vertebra and the abundantest structural protein of invertebrates in-vivo content, it makes bone, tendon, soft
Bone and skin have mechanical strength.Collagen protein is one of most protein of mammal in-vivo content,
Account for the 20%-30% of body total protein, be primarily present in skin, skeleton, tendon, soft tissue etc..
Wherein, in Skin Cell epimatrix, about 70%-80% is collagen protein.Collagen protein has good biology
The compatibility, therefore, it is possible to be applied to medical treatment or beauty treatment fields.
From the point of view of biological activity, collagen protein dressing is desirable for the most complete, molecular weight
Big collagen molecules.On the other hand, from the point of view of preferably playing biological activity, it is also desirable to
Collagen protein in collagen protein dressing can Transdermal absorption.But, contradiction, the glue that molecular weight is big
Former protein molecular volume is big, is difficult to Transdermal absorption.Therefore, in conventional research, how to promote collagen
The Transdermal absorption of albumen becomes study hotspot.Such as, the collagen molecules in order to promote molecular weight big is saturating
Skin absorbs, it is possible to use Face film towel collagen type dressing, i.e. by collagen liquid containing being immersed in non-woven fabrics
Deng solid carrier, then it is sealed in container, takes out during use, be pasted on face.Above-mentioned Face film towel type
In collagen protein dressing, collagen liquid is by containing being immersed in the solid carrier with absorbency, can exist relatively
Many collagen liquids and can delay collagen liquid dry up, therefore, it is possible to extend collagen liquid with
The action time of skin surface, promote the infiltration of the collagen molecules that molecular weight is big.
On the other hand, the use of collagen protein casting product generally require and carry out in indoor (such as beauty parlor,
Hospital etc.), (user can connect to want to the most i.e. complete use as end user
The time of once beauty treatment or the medical treatment that are subject to is usually about 30 minutes), and the prolongation of action time makes U.S.
Appearance/medical treatment occupies the plenty of time of end user, this reduces the applicable model of collagen protein casting product
Enclose and the market competitiveness.From the point of view of this angle, need Transdermal absorption fireballing collagen protein dressing badly and produce
Product.But regrettably, research so far is only all the transdermal absorption factor paying close attention to collagen protein, and
Do not pay close attention to the Transdermal absorption speed of collagen protein.
Summary of the invention
In view of the above-mentioned problems in the prior art, it is an object of the invention to provide one and can promote glue
The aquogel type collagen protein dressing that former albumen, particularly macromolecule collagen protein rapid transdermal absorb.
The starting point, through further investigation, is placed on the saturating of the collagen protein that is the most never concerned by inventors etc.
In skin infiltration rate, found that: for aquogel type collagen protein dressing, suitable macromole
The microenvironment that polymer-collagen protein molecular and skin surface are constituted can promote collagen protein, particularly
The rapid transdermal of macromolecule collagen protein absorbs, thus completes the present invention.
That is, the present invention is as follows.
1. an aquogel type collagen protein dressing, comprising:
Water,
It is distributed in the collagen protein in described water and macromolecule polyalcohol；
Wherein,
Described water is 100:0.01～1 with the weight ratio of described macromolecule polyalcohol,
The content of described collagen protein is 0.02～2 weight %, total with this aquogel type collagen protein dressing
Weight as 100 weight %,
Described macromolecule polyalcohol is selected from hyaluronate sodium, HANSHENGJIAO, carbomer, cellulose, OK a karaoke club
One or more in glue, pectin, sodium alginate.
2. according to the aquogel type collagen protein dressing described in item 1, wherein, the molecule of described collagen protein
Amount is 50,000～350,000 dalton.
3., according to the aquogel type collagen protein dressing described in item 1 or 2, it also includes being positioned at described water two
The packing container layer of side, described packing container layer forms packing container, is accommodated in wherein by described water.
4. it is applicable to oil according to the aquogel type collagen protein dressing according to any one of item 1～3 in preparation
Purposes in the Medical dressing of property skin or face-beautifying dressing.
The present invention achieves techniques below effect: used by the aquogel type collagen protein dressing of the present invention
When skin, macromolecule polyalcohol-both collagen molecules and skin surface constitute suitable micro-loop
Border so that the Transdermal absorption speed of collagen protein is accelerated, and 30 minutes transdermal absorption factors of collagen protein are notable
Improve.Particularly, for using the collagen protein dressing of macromolecule collagen protein, collagen protein
The raising of 30 minutes transdermal absorption factors is the most notable.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention will be described in detail.
The present invention provides a kind of aquogel type collagen protein dressing, comprising:
Water,
It is distributed in the collagen protein in described water and macromolecule polyalcohol；
Wherein,
Described water is 100:0.01～1 with the weight ratio of described macromolecule polyalcohol,
The content of described collagen protein is 0.02～2 weight %, total with this aquogel type collagen protein dressing
Weight as 100 weight %,
Described macromolecule polyalcohol is selected from hyaluronate sodium, HANSHENGJIAO, carbomer, cellulose, OK a karaoke club
One or more in glue, pectin, sodium alginate.
In this manual, " it is distributed " and refers to " dissolving " or " dispersion ".
In the present invention, collagen protein includes the intact collagen albumen without hydrolysis, also includes intact collagen
The hydrolysate in various degree of albumen.
Generally, although the big collagen protein of molecular weight is likely to be of more preferable biological activity, but compared to little
The collagen protein of molecular weight is but difficult to Transdermal absorption, therefore, except some through molecular modification more skin
Outside the genetic engineering collagen protein of skin affinity, the nourishing effect to skin of other macromolecule collagen protein
It is rather limited.
But, the present inventor finds through further investigation, for aquogel type collagen protein dressing, as
Fruit makes macromolecule polyalcohol-collagen molecules constitute suitable microenvironment with skin surface, then can add
The Transdermal absorption speed of fast collagen protein.More it is essential that present inventors have recognized that, it is suitable for collagen egg
The white microenvironment of rapid transdermal absorption and the kind of macromolecule polyalcohol and content, macromolecule polyalcohol-glue
The proportioning of former protein molecular is closely related.
Therefore, in the present invention, described macromolecule polyalcohol is selected from hyaluronate sodium, HANSHENGJIAO, card
One or more in ripple nurse, cellulose, carrageenan, pectin, sodium alginate.Described water and institute
The weight ratio stating macromolecule polyalcohol can be 100:0.01～1, or can be 100:0.02～0.9, or
Person can be 100:0.05～0.8.In the present invention, the content of described collagen protein is 0.02～2 weight %,
It is preferably 0.03～1.5 weight %, more preferably 0.05～1 weight %, applies with this aquogel type collagen protein
The gross weight of material is as 100 weight %.
Molecular weight for described collagen protein is not particularly limited, and can be 1000～50,000 dalton,
Can also be 50,000～350,000 dalton (macromolecule collagen protein), from can fully show quickening thoroughly
From the perspective of the effect of skin infiltration rate, preferably 50,000～350,000 dalton (macromolecule collagen protein).
Additionally, described collagen protein is it is also preferable that intact collagen albumen.In one preferred embodiment, institute
Stating collagen protein is that (Human-like Collagen, HLC see Chinese patent Shen to Human-like Collagen
CN1371919A please be disclose).
As the method being dissolved or dispersed in water by collagen protein, prior art can be used, such as:
Collagen protein is directly dissolved in water；Or, collagen protein is dissolved in acid or alkali, treats that it is the most molten
Xie Hou, then regulate its pH to required pH.
As the method being dissolved or dispersed in water by macromolecule polyalcohol, prior art, example can be used
As: macromolecule polyalcohol is directly dissolved or swelling in water；Or, first macromolecule polyalcohol is disperseed
In the polyhydric alcohol such as glycerol, propylene glycol, butanediol, then it is dissolved in water.
When the aquogel type collagen protein dressing of the present invention is applied to skin, it is possible to accelerate collagen protein
Transdermal absorption speed, considerably increase 30 minutes transdermal absorption factors of collagen protein.Particularly, for
It is difficult to the macromolecule collagen protein of Transdermal absorption, the raising effect of 30 minutes transdermal absorption factors of collagen protein
Fruit is the most notable, therefore, it can once improve looks at user acceptable or obtain more in treatment time
For preferable effect.Therefore, the collagen protein dressing of the present invention achieves important breakthrough on technique effect.
In this manual, " 30 minutes transdermal absorption factors of collagen protein " refers to apply from starting to use collagen protein
Material is when playing 30 minutes, infiltrates into the ratio of collagen protein in skin.30 minutes transdermals of collagen protein
Absorbance can use method to be as shown in the Examples measured.
The collagen protein dressing of the present invention does not comprise oil components, thus is particularly well-suited to oily skin.
Therefore, the present invention also provides for above-mentioned aquogel type collagen protein dressing and is applicable to the doctor of oily skin in preparation
Treat the purposes in dressing or face-beautifying dressing.When preparing Medical dressing or face-beautifying dressing, above-mentioned aquogel type
The both sides of the described water of collagen protein dressing can arrange packing container layer, and described packing container layer forms bag
Packaging container, is accommodated in described water wherein.The material constituting packing container layer is not particularly limited, its
Include but not limited to pottery, glass, metal, plastics etc..Packing container can airtight can not also be airtight,
But it is the most airtight.
Embodiment
Hereinafter, by embodiment, the present invention is carried out more specific description, but the present invention is not implemented by these
The restriction of example.
The intact collagen albumen used in following embodiment and comparative example is commercial goods, and molecular weight is 300
kDa。
The Human-like Collagen used in following embodiment and comparative example is open by Chinese patent application
Fan Human-like Collagen prepared by method described in CN1371919A is (by the ammonia shown in SEQ ID NO:1
Base acid sequence forms), confirm that its molecular weight is 90kDa.
The gelatin (a kind of collagen hydrolysate) used in following embodiment and comparative example is commercial goods,
Molecular weight is 50kDa～70kDa.
The collagen peptide used in following embodiment and comparative example is commercial goods, and molecular weight is 1
KDa～3kDa.
In order to observe intact collagen albumen, Human-like Collagen, gelatin and the transdermal of collagen peptide
Absorption behavior, uses conventional method with FITC (fluorescein isothiocyanate, Fluorescein isothiocyanate)
They have been carried out fluorescent labeling.
If no special instructions, " % " in the description below refers to " weight % ".
Embodiment 1. aquogel type collagen protein dressing 1 (0.05% complete macromolecular collagen protein+water+macromole
Polymer)
Composition: hyaluronate sodium 0.05% (macromolecule polyalcohol), glycerol 8.0%, butanediol 5.0%,
Glycerin polyether-26 2.0%, tocopherol acetas 0.5%, complete macromolecular collagen protein 0.05%,
Phenoxyethanol 0.2%, Sensiva SC50 0.1%, triethanolamine 0.6% so that total amount is 100%
Water.
Technological operation:
1. the acetic acid using 0.05mol/L is pre-dissolved complete macromolecular collagen protein, uses after being completely dissolved
It is 5.0-6.0 that the sodium hydroxide solution of 0.01mol/L adjusts its pH, and constant volume makes its mother solution final concentration of
0.05%；
2. being added to the water by hyaluronate sodium, stirring is to the most swelling；Then be sequentially added into glycerol, butanediol,
Glycerin polyether-26, are stirred until homogeneous in a heated condition, are subsequently adding quantitative collagen protein mother solution, stir
Mix to uniformly, under the conditions of 80-85 DEG C, be incubated 30min；
3. after insulation terminates, it is cooled to 40-45 DEG C, adds tocopherol acetas, phenoxyethanol, ethylhexyl
Glycerol, after stirring, adds triethanolamine, is stirred until homogeneous, lowers the temperature.
Embodiment 2. aquogel type collagen protein dressing 2 (0.1% Human-like Collagen+water+macromolecule polyalcohol)
Composition: sodium alginate 0.05%, pectin 0.2% (macromolecule polyalcohol), glycerol 5.0%, fourth two
Alcohol 3.0%, glycine betaine 2.0%, tocopherol acetas 0.5%, Human-like Collagen 0.1%, benzene
Oxyethanol 0.2%, Sensiva SC50 0.1%, triethanolamine 0.5% so that total amount is 100%
Water.
Technological operation:
1. sodium alginate, pectin are added to the water, and stirring is to the most swelling；Then be sequentially added into glycerol, butanediol,
Glycine betaine, Human-like Collagen, be stirred until homogeneous in a heated condition, is incubated under the conditions of 80-85 DEG C
30min；
2. after insulation terminates, it is cooled to 40-45 DEG C, adds tocopherol acetas, phenoxyethanol, ethylhexyl
Glycerol, after stirring, adds triethanolamine, is stirred until homogeneous, lowers the temperature.
Embodiment 3. aquogel type collagen protein dressing 3 (0.5% gelatin+water+macromolecule polyalcohol)
Composition: HANSHENGJIAO 0.3%, cellulose 0.2% (macromolecule polyalcohol), glycerol 8.0%, fourth two
Alcohol 5.0%, glycerin polyether-26 2.0%, tocopherol acetas 0.5%, gelatin 0.5%, benzene oxygen
Ethanol 0.2%, Sensiva SC50 0.1%, triethanolamine 0.6% so that total amount is 100%
Water.
Technological operation:
1. HANSHENGJIAO, cellulose are added to the water, and stirring is to the most swelling；Then be sequentially added into glycerol, butanediol,
Glycerin polyether-26, gelatin, be stirred until homogeneous in a heated condition, is incubated 30min under the conditions of 80-85 DEG C；
2. after insulation terminates, it is cooled to 40-45 DEG C, adds tocopherol acetas, phenoxyethanol, ethylhexyl
Glycerol, after stirring, adds triethanolamine, is stirred until homogeneous, lowers the temperature.
Embodiment 4. aquogel type collagen protein dressing 4 (1% collagen peptide+water+macromolecule polyalcohol)
Composition: carbomer 0.5%, carrageenan 0.3% (macromolecule polyalcohol), glycerol 5.0%, butanediol
3.0%, glycine betaine 2.0%, tocopherol acetas 0.5%, collagen peptide 1%, phenoxyethanol
0.2%, Sensiva SC50 0.1%, triethanolamine 0.5% so that total amount is the water of 100%.
Technological operation:
1. carbomer, carrageenan are added to the water, and stirring is to the most swelling；Then be sequentially added into glycerol, butanediol,
Glycine betaine, collagen peptide, be stirred until homogeneous in a heated condition, is incubated 30min under the conditions of 80-85 DEG C；
2. after insulation terminates, it is cooled to 40-45 DEG C, adds tocopherol acetas, phenoxyethanol, ethylhexyl
Glycerol, after stirring, adds triethanolamine, is stirred until homogeneous, lowers the temperature.
Comparative example 1. aqueous phase collagen protein dressing 1 (0.05% macromolecular collagen protein+water)
Composition: glycerol 8.0%, butanediol 5.0%, glycerin polyether-26 2.0%, tocopherol acetas 0.5%,
Macromole intact collagen albumen 0.05%, phenoxyethanol 0.2%, Sensiva SC50 0.1%, three
Ethanolamine 0.6% so that total amount is the water of 100%.
Technological operation:
1. the acetic acid using 0.05mol/L is pre-dissolved complete macromolecular collagen protein, uses after being completely dissolved
It is 5.0-6.0 that the sodium hydroxide solution of 0.01mol/L adjusts its pH, and constant volume makes its mother solution final concentration of
0.05%；
2. by glycerol, butanediol, glycerin polyether-26 mixing post-heating stirring, it is subsequently adding quantitative collagen protein
Mother solution, is stirred until homogeneous, and is incubated 30min under the conditions of 80-85 DEG C；
3. after insulation terminates, it is cooled to 40-45 DEG C, adds tocopherol acetas, phenoxyethanol, ethylhexyl
Glycerol, after stirring, adds triethanolamine, is stirred until homogeneous, lowers the temperature.
Comparative example 2. aquogel type collagen protein dressing 2 (0.1% Human-like Collagen+water+macromolecule polyalcohol)
Composition: sodium alginate 1%, pectin 0.2% (macromolecule polyalcohol), glycerol 5.0%, butanediol
3.0%, glycine betaine 2.0%, tocopherol acetas 0.5%, Human-like Collagen 0.1%, benzene oxygen
Ethanol 0.2%, Sensiva SC50 0.1%, triethanolamine 0.5% so that total amount is 100%
Water.
Technological operation:
1. sodium alginate, pectin are added to the water, and stirring is to the most swelling；Then be sequentially added into glycerol, butanediol,
Glycine betaine, Human-like Collagen, be stirred until homogeneous in a heated condition, is incubated under the conditions of 80-85 DEG C
30min；
2. after insulation terminates, it is cooled to 40-45 DEG C, adds tocopherol acetas, phenoxyethanol, ethylhexyl
Glycerol, after stirring, adds triethanolamine, is stirred until homogeneous, lowers the temperature.
Comparative example 3. aquogel type collagen protein dressing 3 (0.5% gelatin+water+macromolecule polyalcohol)
Composition: Radix Acaciae senegalis 0.5% (macromolecule polyalcohol), glycerol 8.0%, butanediol 5.0%,
Glycerin polyether-26 2.0%, tocopherol acetas 0.5%, gelatin 0.5%, phenoxyethanol 0.2%,
Sensiva SC50 0.1%, triethanolamine 0.6% so that total amount is the water of 100%.
Technological operation:
1. Radix Acaciae senegalis is added to the water, and stirring is to the most swelling；Then glycerol, butanediol, sweet it is sequentially added into
Oil polyethers-26, gelatin, be stirred until homogeneous in a heated condition, is incubated 30min under the conditions of 80-85 DEG C；
2. after insulation terminates, it is cooled to 40-45 DEG C, adds tocopherol acetas, phenoxyethanol, ethylhexyl
Glycerol, after stirring, adds triethanolamine, is stirred until homogeneous, lowers the temperature.
Comparative example 4. aquogel type collagen protein dressing 4 (5% collagen peptide+water+macromolecule polyalcohol)
Composition: carbomer 0.5%, carrageenan 0.3% (macromolecule polyalcohol), glycerol 5.0%, fourth two
Alcohol 3.0%, glycine betaine 2.0%, tocopherol acetas 0.5%, collagen peptide 5%, benzene oxygen
Ethanol 0.2%, Sensiva SC50 0.1%, triethanolamine 0.5% so that total amount is 100%
Water.
Technological operation:
1. carbomer, carrageenan are added to the water, and stirring is to the most swelling；Then be sequentially added into glycerol, butanediol,
Glycine betaine, collagen peptide, be stirred until homogeneous in a heated condition, is incubated 30min under the conditions of 80-85 DEG C；
2. after insulation terminates, it is cooled to 40-45 DEG C, adds tocopherol acetas, phenoxyethanol, ethylhexyl
Glycerol, after stirring, adds triethanolamine, is stirred until homogeneous, lowers the temperature.
The mensuration of 30 minutes transdermal absorption factors of collagen protein
Carry losing hair or feathers adapting to the mice of feeding environment at laboratory preserved skin with depilatory the previous day.Experiment
Front use bath gel or cleansing milk are to carrying out skin clean and by towel at preserved skin, by above-mentioned each enforcement
Example and the dressing of comparative example, spread upon at preserved skin of the same area with medical cotton stick with equal amount respectively, is coated with
After having smeared, normal raising, only does each group of mice 5 Irrigation at preserved skin with clear water when 0.5h
Only, using fluorescence microplate reader that the collagen protein in cleanout fluid is carried out quantitative analysis, it is just the failure to transdermal
Collagen protein.
Wherein, skin permeation rate so calculates: skin permeation rate=(the collagen protein total amount smeared-fail transdermal
Collagen protein amount)/collagen protein the total amount smeared.
For each embodiment and the dressing of comparative example, the meansigma methods of above-mentioned skin permeation rate test result is shown in down
State in table 1.
The skin permeation rate of table 1 each collagen protein dressing
Wherein, skin permeation rate so calculates: skin permeation rate=(glue of the collagen protein total amount smeared-fail transdermal
Former protein content)/collagen protein the total amount smeared.
Also, it should be noted can implement and on the premise of the inconspicuous purport running counter to the present invention, at this
As the arbitrary technical characteristic described by the composition part of a certain technical scheme or technical characteristic in description
Combination be readily adaptable for use in other technical scheme equally；Further, can implement and inconspicuous run counter to this
On the premise of bright purport, as between the technical characteristic described by the composition part of different technologies scheme also
Can be combined in any way, constitute other technical scheme.The present invention is also contained in above-mentioned situation
Under the technical scheme that obtained by combination, and these technical schemes are equivalent to record in this manual.
Describe the present invention above by detailed description of the invention and embodiment, but people in the art
Member it should be understood that these to be not intended to the scope of the present invention and is defined, and the scope of the present invention should
Determined by claims.
Industrial applicibility
The collagen protein dressing of the present invention has the effect promoting collagen molecules Transdermal absorption, thus more
It is suitable as medical collagen dressing.
Claims (4)
1. an aquogel type collagen protein dressing, comprising:
Water,
It is distributed in the collagen protein in described water and macromolecule polyalcohol；
Wherein,
Described water is 100:0.01～1 with the weight ratio of described macromolecule polyalcohol,
The content of described collagen protein is 0.02～2 weight %, with this aquogel type collagen protein dressing
Gross weight as 100 weight %,
Described macromolecule polyalcohol is selected from hyaluronate sodium, HANSHENGJIAO, carbomer, cellulose, card
Draw in glue, pectin, sodium alginate one or more.
Aquogel type collagen protein dressing the most according to claim 1, wherein, described collagen protein
Molecular weight be 50,000～350,000 dalton.
Aquogel type collagen protein dressing the most according to claim 1 and 2, it also includes being positioned at institute
Stating the packing container layer of water both sides, described packing container layer forms packing container, and described water is accommodated in it
In.
4. suitable in preparation according to the aquogel type collagen protein dressing according to any one of claims 1 to 3
Purposes in the Medical dressing or face-beautifying dressing of oily skin.
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| CN201510080027.0A CN105983131A (en) | 2015-02-13 | 2015-02-13 | Hydrogel collagen dressing especially suitable for oily skins |
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| CN201510080027.0A CN105983131A (en) | 2015-02-13 | 2015-02-13 | Hydrogel collagen dressing especially suitable for oily skins |
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| CN110075343A (en) * | 2019-05-17 | 2019-08-02 | 江苏西宏生物医药有限公司 | Medical reparation skin cold compress patch of one kind and preparation method thereof |
| CN111743788A (en) * | 2020-06-29 | 2020-10-09 | 华仁药业股份有限公司 | Collagen dressing containing icodextrin |
| CN112120958A (en) * | 2020-10-10 | 2020-12-25 | 三亚悦美科技有限公司 | Skin repairing dressing and preparation method thereof |
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| CN113476647A (en) * | 2021-08-17 | 2021-10-08 | 上海迪派生物科技有限公司 | Trehalose gel dressing and preparation method thereof |
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| CN114224773A (en) * | 2021-12-28 | 2022-03-25 | 江苏聚源医疗技术有限公司 | Medical gel containing recombinant humanized collagen and preparation method thereof |
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| CN106492267B (en) * | 2016-11-25 | 2021-09-17 | 陕西巨子生物技术有限公司 | Human-like collagen anorectal mucosa repair gel |
| CN110075343A (en) * | 2019-05-17 | 2019-08-02 | 江苏西宏生物医药有限公司 | Medical reparation skin cold compress patch of one kind and preparation method thereof |
| CN111743788A (en) * | 2020-06-29 | 2020-10-09 | 华仁药业股份有限公司 | Collagen dressing containing icodextrin |
| CN112120958A (en) * | 2020-10-10 | 2020-12-25 | 三亚悦美科技有限公司 | Skin repairing dressing and preparation method thereof |
| CN112314935A (en) * | 2020-11-19 | 2021-02-05 | 华中农业大学 | Preparation method of collagen-polysaccharide composite hydrogel and product thereof |
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| CN113786513A (en) * | 2021-10-25 | 2021-12-14 | 西安德诺海思医疗科技有限公司 | Long-term stable recombinant collagen dressing and preparation method thereof |
| CN114224773A (en) * | 2021-12-28 | 2022-03-25 | 江苏聚源医疗技术有限公司 | Medical gel containing recombinant humanized collagen and preparation method thereof |
| CN115844754A (en) * | 2022-12-19 | 2023-03-28 | 成都奇璞生物科技有限公司 | Collagen dressing liquid, preparation method thereof and collagen dressing patch |
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