CN106492267A - A kind of Human-like Collagen anorectal Mucous rehabilitation gel - Google Patents
A kind of Human-like Collagen anorectal Mucous rehabilitation gel Download PDFInfo
- Publication number
- CN106492267A CN106492267A CN201611055725.6A CN201611055725A CN106492267A CN 106492267 A CN106492267 A CN 106492267A CN 201611055725 A CN201611055725 A CN 201611055725A CN 106492267 A CN106492267 A CN 106492267A
- Authority
- CN
- China
- Prior art keywords
- collagen
- human
- weight
- phases
- anorectal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0033—Collagen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of Human-like Collagen anorectal Mucous rehabilitation gel.The Human-like Collagen anorectal Mucous rehabilitation gel of the present invention includes 0.1～1 weight % of Human-like Collagen, 0.75～0.85 weight % of carbomer, 20～25 weight % of glycerol, 0.001～0.01 weight % of hyaluronate sodium, 0.12～0.2 weight % of sodium hydroxide, 0.1～0.5 weight % of ethyl hydroxybenzoate, 0.2～1 weight % of shitosan, and the water of surplus.When the Human-like Collagen gel of the present invention is applied to the damaged anorectal epidermis of mucosa, can significantly more accelerate the Transdermal absorption speed of Human-like Collagen.So as to the Human-like Collagen gel of the present invention can provide preferably nourishing, stimulate mucosa cells regeneration, promote the reparation of impaired anorectal mucosa.
Description
Technical field
The present invention relates to Human-like Collagen dressing, and in particular to be particularly well-suited to anorectal cell migration comprising class people's glue
The gel of former albumen, belongs to health care/medical instruments field.
Background technology
Human-like Collagen is by model (the disclosing referring to Chinese patent application for sister-in-law's teaching inventive of NW China university
Bright book CN1371919A), therefore also referred to as Fan Shi recombined collagens or Fan Human-like Collagen (Fan ' s Human-like
Collagen, FHLC).Human-like Collagen is a kind of recombined collagen of high-biocompatibility, is now widely used for curing
Treat or beauty treatment fields.
On the other hand, collagen protein casting product be used for for example nasal cavity, anorectal, gynecological's position mucosa moisten and protection
In the case of, the use of collagen protein casting product generally requires to carry out (the ear nose section of such as hospital, anorectum department and gynecological indoors
Deng), want to complete at short notice to use that (time of user acceptable medical treatment is usual as end user
For 30 minutes or so), and the prolongation of action time causes medical treatment to occupy the plenty of time of end user, this reduces collagen
The scope of application and the market competitiveness of albumen casting product.From for this angle, the fireballing collagen egg of Transdermal absorption is needed badly
White casting product.But regrettably, correlational study more pays close attention to the transdermal absorption factor of collagen protein, and does not pay close attention to the saturating of collagen protein
Skin infiltration rate.
In this regard, the present inventor has invented a kind of Human-like Collagen cell migration gel, it is suitable which may pass through composition
Microenvironment so that the Transdermal absorption speed of Human-like Collagen is accelerated, and refers to Chinese patent application publication number CN105709267A.
The Human-like Collagen cell migration gel is also disclosed in the patent documentation can be used for such as nasal mucosa, anorectal mucosa or woman
The reparation of section's position mucosa.
Content of the invention
However, the present inventor is had found through more in-depth study, in above-mentioned Human-like Collagen cell migration gel
In development process, only it is the investigation place using body skin as Human-like Collagen Transdermal absorption speed, emphasis does not consider such
The local microenvironment at the practical application position of human collagen cell migration gel, causes Human-like Collagen Transdermal absorption speed
Though degree increases, not yet perfect.
In view of the above-mentioned problems in the prior art, it is an object of the invention to provide one kind is particularly well-suited to anorectal mucosa
Gel that repair, that Human-like Collagen rapid transdermal can be promoted to absorb.
That is, the present invention is as follows.
1. a kind of Human-like Collagen anorectal cell migration gel, which includes:
2. use of the Human-like Collagen gel described in 1 in the medical dressing for anorectal cell migration is prepared
On the way.
3. the method for the Human-like Collagen gel described in a kind of preparation 1, the method include：
Step A：Prepare A phases, the A phases by the carbomer of 0.75～0.85 weight %, the glycerol of 5～10 weight %,
The water composition of the hyaluronate sodium of 0.001～0.01 weight % and surplus；
Step B：Prepare B phases, the B phases are the water groups of the sodium hydroxide by 0.12～0.2 weight % and 1～3 weight %
Into sodium hydrate aqueous solution；
Step C：Prepare C phases, the C phases are the glycerol of the ethyl hydroxybenzoate of 0.1～0.5 weight % and 20～10 weight %
Mixture；
Step D：Prepare D phases, the D phases are the shitosans of 0.2～1 weight %；
Step E：Prepare E phases, the E phases are Human-like Collagen liquid, and which includes the Human-like Collagen anus so that described
Intestinal mucosa repairs the Human-like Collagen that the content of Human-like Collagen in gel is 0.1～1 weight %, and medium is water, and institute
The weight ratio that Human-like Collagen is stated with the water is 1:1～20；And
Step F：The D is added in the A phases and is stirred, be subsequently adding the B phases and stir, then plus
Entering the C phases and the E phases and stirring, 60～120 minutes are incubated in 80～85 DEG C, insulation stirs after terminating, cold
But to room temperature；
Gross weight using the Human-like Collagen gel is used as 100 weight %.
The present invention achieves following technique effect：The Human-like Collagen gel of the present invention is being applied to mucosa breakage
During anorectal epidermis, can significantly more accelerate the Transdermal absorption speed of Human-like Collagen.So as to the Human-like Collagen of the present invention
Gel can provide preferably nourishing, stimulating mucosal cell regeneration, promote the reparation of impaired anorectal mucosa.
Specific embodiment
With reference to specific embodiment, the present invention will be described in detail.
The present invention provides a kind of Human-like Collagen anorectal cell migration gel (the Human-like Collagen gel of the present invention),
Which includes:
In this manual, Human-like Collagen anorectal cell migration gel is referred to comprising Human-like Collagen as effective
Gel composition, being applied to anorectal cell migration.
In this manual, Human-like Collagen refers to that Chinese patent application discloses claim 1 institute of CN1371919A
The recombined collagen that states, can disclose the gene engineering expression disclosed in CN1371919A using the such as Chinese patent application
Method is preparing.Human-like Collagen be by NW China university model for sister-in-law's teaching inventive, therefore also referred to as Fan Shi restructuring
Collagen protein or Fan Human-like Collagen (Fan ' s Human-like Collagen, FHLC).
Carbomer is the acrylic acid and allyl sucrose or the high molecular polymer of Allyl pentaerythritol ether of synthesis.For
The carbomer is not particularly limited, it is possible to use that generally used in cosmetics or medical dressing of those skilled in the art
A little carbomers, the carbomer that for example can be produced using Guangzhou Concho Hampshire Pharmaceutical Co., Ltd, CAS No：9003-01-4.
For the glycerol is not particularly limited, it is possible to use those skilled in the art are generally in cosmetics or medical dressing
Used in those glycerol, the glycerol that for example can be produced using Hu'nan Erkang Pharmaceutical Co., Ltd., CAS No：56-81-
5.
For the hyaluronate sodium is not particularly limited, it is possible to use those skilled in the art are generally in cosmetics or doctor
With those hyaluronate sodiums used in dressing, for example can using Bloomage Freda Biopharm Co., Ltd. produce transparent
Matter acid sodium, product code：HA-T.
For the shitosan is not particularly limited, it is possible to use those skilled in the art are generally in cosmetics or Medical coating
Those shitosans used in material, for example, can use the shitosan of Zhejiang golden shell pharmaceutcal corporation, Ltd production, CAS No：
9012-76-4.
For the ethyl hydroxybenzoate is not particularly limited, it is possible to use those skilled in the art are generally in cosmetics or medical
Those ethyl hydroxybenzoates used in dressing, the ethyl hydroxybenzoate that for example can be produced using Hu'nan Erkang Pharmaceutical Co., Ltd.,
CAS No：120-47-8.
By the present invention Human-like Collagen gel be applied to anorectal damaged part when so that Human-like Collagen saturating
Skin infiltration rate is accelerated, and 30 minutes transdermal absorption factors of Human-like Collagen are further significantly improved on the basis of existing product
(even more than 50%), its reason are likely due to constitute more suitable microenvironment.
Also, it should be noted the inventors discovered that, poly- Pyrusussuriensiss can not be included in the Human-like Collagen gel of the present invention
Alkoxide, such as polysorbate80 etc..The polysorbate esters can significantly reduce the Human-like Collagen gel of the present invention
Transdermal absorption effect.
The Human-like Collagen gel of the present invention is particularly suitable for being used for anorectal cell migration in medical treatment/healthcare field.With
When the anorectal cell migration purposes of medical treatment/healthcare field, the Human-like Collagen gel of the present invention itself can be used as dressing
Use, it is also possible to make other kinds of dressing or other dosage forms (such as suppository etc.) again with other carriers or auxiliary material combination.
For the preparation method of the Human-like Collagen gel of the present invention is not particularly limited, its preparation method can be wrapped
Include：
Step A：Prepare A phases, the A phases by the carbomer of 0.75～0.85 weight %, the glycerol of 5～10 weight %,
The water composition of the hyaluronate sodium of 0.001～0.01 weight % and surplus；
Step B：Prepare B phases, the B phases are the water groups of the sodium hydroxide by 0.12～0.2 weight % and 1～3 weight %
Into sodium hydrate aqueous solution；
Step C：Prepare C phases, the C phases are the glycerol of the ethyl hydroxybenzoate of 0.1～0.5 weight % and 20～10 weight %
Mixture；
Step D：Prepare D phases, the D phases are the shitosans of 0.2～1 weight %；
Step E：Prepare E phases, the E phases are Human-like Collagen liquid, and which includes the Human-like Collagen anus so that described
Intestinal mucosa repairs the Human-like Collagen that the content of Human-like Collagen in gel is 0.1～1 weight %, and medium is water, and institute
The weight ratio that Human-like Collagen is stated with the water is 1:1～20；And
Step F：The D is added in the A phases and is stirred, be subsequently adding the B phases and stir, then plus
Entering the C phases and the E phases and stirring, 60～120 minutes are incubated in 80～85 DEG C, insulation stirs after terminating, cold
But to room temperature；
Gross weight using the Human-like Collagen gel is used as 100 weight %.
Here, Human-like Collagen liquid includes the aqueous dispersions of the aqueous solution and Human-like Collagen of Human-like Collagen.
Here, the order of step A, B, C, D, E is not particularly limited, can be successively carried out with random order or same
Shi Jinhang.
Preferably, the A phases be by with glycerol by carbomer and hyaluronic acid dispersion after be added to the water, and stir to complete
CL and prepare.
Here, for the mode of stirring is not particularly limited, as long as can stir.
The Human-like Collagen gel of the present invention can be placed in packing container.There is no spy to the material for constituting packing container
Different restriction, which includes but is not limited to pottery, glass, metal, plastics etc..Packing container can with closed can not also be closed, but excellent
Select closed.
Embodiment
Hereinafter, more specific description is carried out to the present invention by embodiment, but the present invention is not restricted by the embodiments.
Human-like Collagen used in following embodiments and comparative example is to disclose CN1371919A by Chinese patent application
Fan Human-like Collagen prepared by methods described is (by SEQ ID NO:Aminoacid sequence composition shown in 1), confirm its molecule
Measure as 90kDa.
In order to observe the Transdermal absorption behavior of Human-like Collagen, using conventional method FITC (fluorescein
Isothiocyanate, Fluorescein isothiocyanate) fluorescent labeling has been carried out to which.
If no special instructions, " % " in the description below refers to " weight % ".
The preparation of the Human-like Collagen anorectal cell migration gel of 1. present invention of embodiment
Composition：Carbomer 0.8%, glycerol 22%, hyaluronate sodium 0.005%, sodium hydroxide 0.15%, ethyl hydroxybenzoate
0.2%, shitosan 0.5%, Human-like Collagen 0.5%, water surplus.
Technological operation：
1. first carbomer, hyaluronate sodium, glycerol (8 weight %) are added to the water, are then slowly added into after shitosan not
Disconnected stir to being completely dispersed.
2. sodium hydrate aqueous solution is subsequently added in above-mentioned solution, after stirring, be slowly added into ethyl hydroxybenzoate and sweet
The mixed liquor and Human-like Collagen liquid of oil, after stirring, is incubated 90 minutes in 82 DEG C, and insulation stirs after terminating,
It is cooled to room temperature.
The preparation of comparative example 1. other Human-like Collagen anorectal cell migration gels
Composition：Carbomer 1.5%, glycerol 22%, hyaluronate sodium 0.005%, sodium hydroxide 0.15%, ethyl hydroxybenzoate
0.2%, shitosan 2%, Human-like Collagen 0.5%, water surplus.
Technological operation：
1. first carbomer, hyaluronate sodium, glycerol (8 weight %) are added to the water, are then slowly added into after shitosan not
Disconnected stir to being completely dispersed.
2. sodium hydrate aqueous solution is subsequently added in above-mentioned solution, after stirring, be slowly added into ethyl hydroxybenzoate and sweet
The mixed liquor and Human-like Collagen liquid of oil, after stirring, is incubated 90 minutes in 82 DEG C, and insulation stirs after terminating,
It is cooled to room temperature.
The preparation of comparative example 2. other Human-like Collagen anorectal cell migration gels
Composition：Carbomer 0.8%, glycerol 22%, hyaluronate sodium 0.005%, sodium hydroxide 0.15%, ethyl hydroxybenzoate
0.2%, shitosan 0.5%, Human-like Collagen 0.5%, tween 80 0.5%, water surplus.
Technological operation：
1. first carbomer, hyaluronate sodium, glycerol (8 weight %) are added to the water, are then slowly added into after shitosan not
Disconnected stir to being completely dispersed.
2. sodium hydrate aqueous solution is subsequently added in above-mentioned solution, after stirring, be slowly added into ethyl hydroxybenzoate and sweet
The mixed liquor and Human-like Collagen liquid of oil, after stirring, is incubated 90 minutes in 82 DEG C, and insulation stirs after terminating,
Polysorbate80 is added, after stirring, room temperature is cooled to.
The preparation of comparative example 3. other Human-like Collagen anorectal cell migration gels
Composition：Carbomer 1%, glycerol 22%, hyaluronate sodium 0.005%, sodium hydroxide 0.09%, ethyl hydroxybenzoate
0.2%, shitosan 0.5%, Human-like Collagen 0.5%, water surplus.
Technological operation：
1. first carbomer, hyaluronate sodium, glycerol (8 weight %) are added to the water, are then slowly added into after shitosan not
Disconnected stir to being completely dispersed.
2. sodium hydrate aqueous solution is subsequently added in above-mentioned solution, after stirring, be slowly added into ethyl hydroxybenzoate and sweet
The mixed liquor and Human-like Collagen liquid of oil, after stirring, is incubated 90 minutes in 82 DEG C, and insulation stirs after terminating,
It is cooled to room temperature.
The measure of 30 minutes transdermal absorption factors of collagen protein
The Rat Fast 1 day of feeding environment is adapted in laboratory, rat anesthesia has been passed through with 4% acetic acid cotton swab
Rat anus inserts rectum 1 minute, and placed-depth is 3 centimetres, prepares (the reference of the acute mucous membrane of rectum damage model of model group rats
Building rosy clouds etc., acetic acid induction set up the morphological observation of rat acute mucous membrane of rectum damage model, in April, 2015 volume 23 the 2nd
Phase).The Human-like Collagen anorectal cell migration gel of above-described embodiment and comparative example is injected into Rat-rectum with equal amount,
Normally raise after the completion of inserting, by 5 execution of each group rat when 0.5h, cut off test organization position and clean up, adopt
Fluorescence microplate reader to cleanout fluid in collagen protein carry out quantitative analyses, which is just the failure to the collagen protein of transdermal.
Wherein, skin permeation rate is so calculated：Skin permeation rate=(the collagen protein of the collagen protein total amount of injection-fail transdermal
Amount)/injection collagen protein total amount.
For the Human-like Collagen anorectal cell migration gel of each embodiment and comparative example, by above-mentioned skin permeation rate test knot
The meansigma methodss of fruit are shown in table 1 below.
The transdermal absorption factor of 1 each collagen gel of table
| No | 30 minutes transdermal absorption factors of collagen protein |
| Embodiment 1 | 65% |
| Comparative example 1 | 43% |
| Comparative example 2 | 39% |
| Comparative example 3 | 31% |
Industrial applicibility
In accordance with the invention it is possible to provide a kind of Human-like Collagen gel for being particularly well-suited to anorectal cell migration.
Claims (3)
1. a kind of Human-like Collagen anorectal cell migration gel, which includes:
2. the Human-like Collagen anorectal cell migration gel described in claim 1 is preparing the medical treatment for anorectal cell migration
With the purposes in dressing.
3. a kind of method of the Human-like Collagen anorectal cell migration gel prepared described in claim 1, the method include：
Step A：Prepare A phases, the A phases by the carbomer of 0.75～0.85 weight %, the glycerol of 5～10 weight %, 0.001～
The water composition of the hyaluronate sodium of 0.01 weight % and surplus；
Step B：Prepare B phases, the B phases are made up of the sodium hydroxide of 0.12～0.2 weight % and the water of 1～3 weight %
Sodium hydrate aqueous solution；
Step C：Prepare C phases, the C phases are the mixing of the glycerol of the ethyl hydroxybenzoate of 0.1～0.5 weight % and 20～10 weight %
Thing；
Step D：Prepare D phases, the D phases are the shitosans of 0.2～1 weight %；
Step E：Prepare E phases, the E phases are Human-like Collagen liquid, which includes so that described Human-like Collagen anorectal glues
In film healing gel, the content of Human-like Collagen is the Human-like Collagen of 0.1～1 weight %, and medium is water, and the class
Human collagen is 1 with the weight ratio of the water:1～20；And
Step F：The D is added in the A phases and is stirred, be subsequently adding the B phases and stir, add institute
Stating C phases and the E phases and stirring, 60～120 minutes are incubated in 80～85 DEG C, insulation stirs after terminating, and is cooled to
Room temperature；
Gross weight using the Human-like Collagen anorectal cell migration gel is used as 100 weight %.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611055725.6A CN106492267B (en) | 2016-11-25 | 2016-11-25 | Human-like collagen anorectal mucosa repair gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611055725.6A CN106492267B (en) | 2016-11-25 | 2016-11-25 | Human-like collagen anorectal mucosa repair gel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106492267A true CN106492267A (en) | 2017-03-15 |
| CN106492267B CN106492267B (en) | 2021-09-17 |
Family
ID=58328913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611055725.6A Active CN106492267B (en) | 2016-11-25 | 2016-11-25 | Human-like collagen anorectal mucosa repair gel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106492267B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107007823A (en) * | 2017-03-21 | 2017-08-04 | 深圳市康思得蛋白质工程有限公司 | It is a kind of to be used to treat medicine of rhinitis and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030069171A1 (en) * | 1998-03-24 | 2003-04-10 | Petito George D. | Nutritional composition for the treatment of connective tissue |
| CN105169374A (en) * | 2015-10-23 | 2015-12-23 | 东莞市达庆医疗器械有限公司 | Recombinant human collagen gel and preparation method thereof |
| CN105709267A (en) * | 2015-12-04 | 2016-06-29 | 陕西巨子生物技术有限公司 | Mucosa-repairing gel containing human-like collagen |
| CN105709216A (en) * | 2015-12-04 | 2016-06-29 | 陕西巨子生物技术有限公司 | Mouth mucosa repairing liquid containing human-like collagen |
| CN105709266A (en) * | 2015-12-04 | 2016-06-29 | 陕西巨子生物技术有限公司 | Scar-repairing silica gel containing human-like collagen |
| CN105983131A (en) * | 2015-02-13 | 2016-10-05 | 陕西巨子生物技术有限公司 | Hydrogel collagen dressing especially suitable for oily skins |
-
2016
- 2016-11-25 CN CN201611055725.6A patent/CN106492267B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030069171A1 (en) * | 1998-03-24 | 2003-04-10 | Petito George D. | Nutritional composition for the treatment of connective tissue |
| CN105983131A (en) * | 2015-02-13 | 2016-10-05 | 陕西巨子生物技术有限公司 | Hydrogel collagen dressing especially suitable for oily skins |
| CN105169374A (en) * | 2015-10-23 | 2015-12-23 | 东莞市达庆医疗器械有限公司 | Recombinant human collagen gel and preparation method thereof |
| CN105709267A (en) * | 2015-12-04 | 2016-06-29 | 陕西巨子生物技术有限公司 | Mucosa-repairing gel containing human-like collagen |
| CN105709216A (en) * | 2015-12-04 | 2016-06-29 | 陕西巨子生物技术有限公司 | Mouth mucosa repairing liquid containing human-like collagen |
| CN105709266A (en) * | 2015-12-04 | 2016-06-29 | 陕西巨子生物技术有限公司 | Scar-repairing silica gel containing human-like collagen |
Non-Patent Citations (3)
| Title |
|---|
| 刘雅敏等: "《药物制剂常用辅料》", 31 January 1994, 天津科技翻译出版公司 * |
| 吴景时等: "《基本药与新药手册》", 31 December 1999, 人民卫生出版社 * |
| 段久芳: "《天然高分子材料》", 30 September 2016, 华中科技大学出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107007823A (en) * | 2017-03-21 | 2017-08-04 | 深圳市康思得蛋白质工程有限公司 | It is a kind of to be used to treat medicine of rhinitis and preparation method thereof |
| CN107007823B (en) * | 2017-03-21 | 2020-07-14 | 深圳市康思得蛋白质工程有限公司 | Medicine for treating rhinitis and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106492267B (en) | 2021-09-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105709267B (en) | A kind of human-like collagen cell migration gel | |
| CN106491518A (en) | A kind of Human-like Collagen gynecological cell migration gel | |
| CN106798655B (en) | Polypeptide composition with breast enlargement effect | |
| CN106619186A (en) | Preparation for protecting activity of superoxide dismutase (SOD) and preparation method of preparation | |
| CN109908005A (en) | A kind of nanogold remediation composition and preparation method thereof | |
| CN106540314A (en) | A kind of Human-like Collagen nasal membrane repairs gel | |
| CN106492267A (en) | A kind of Human-like Collagen anorectal Mucous rehabilitation gel | |
| CN109172613A (en) | The topical compositions of the dead bacterium culture containing lactobacillus, medical composition and its in promoting wound healing and reduce the purposes of scar | |
| CN105709216B (en) | A kind of human-like collagen oral mucosa reparation liquid | |
| CN101491586A (en) | Ointment for combating and treating skin diseases, and process for preparing said ointment | |
| CN102492032A (en) | Human-like collagen and injectable human-like collagen soft-tissue filling material | |
| CN110272547A (en) | A kind of preparation method of fibroin albumen thixotropy gel | |
| CN103243163A (en) | Novel applications of miR-27a (microRNA-27a) | |
| CN106579461A (en) | Collagen protein oral liquid and preparation method thereof | |
| CN102492033A (en) | Human-like collagen and human-like collagen composite sodium hyaluronate hydrogel | |
| WO2023045818A1 (en) | Composition of nintedanib for treating skin diseases formed by neovascularization, and method | |
| CN107913217A (en) | A kind of Noni fruit ferment elite breast and preparation method thereof | |
| CN105709266A (en) | Scar-repairing silica gel containing human-like collagen | |
| CN108635312A (en) | A kind of plant essence scar rehabilitating solution and preparation method thereof | |
| CN106798727A (en) | A kind of utilization infrared light increases the medication of sequences of small interfering RNAs bioactivity in skin | |
| CN100368540C (en) | Production method for recombinant cytoglobin and uses thereof | |
| CN104983724B (en) | A kind of collagen film and preparation method thereof | |
| CN113455465B (en) | Method for constructing nude mouse subcutaneous transplantation model of human prostate cancer LNCaP cell | |
| CN113398248B (en) | External medicine for improving skin flap blood circulation and preparation method thereof | |
| CN108815018A (en) | A kind of castor rat-tail muscle extracts the facial mask liquid and preparation method thereof of collagen peptide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |