CN105709216A - Mouth mucosa repairing liquid containing human-like collagen - Google Patents

Mouth mucosa repairing liquid containing human-like collagen Download PDF

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Publication number
CN105709216A
CN105709216A CN201510883488.1A CN201510883488A CN105709216A CN 105709216 A CN105709216 A CN 105709216A CN 201510883488 A CN201510883488 A CN 201510883488A CN 105709216 A CN105709216 A CN 105709216A
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China
Prior art keywords
collagen
human
oral mucosa
phase
repair liquid
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Granted
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CN201510883488.1A
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Chinese (zh)
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CN105709216B (en
Inventor
范代娣
马晓轩
严建亚
王淑英
常海燕
王小军
杨婵媛
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SHAANXI GIANT BIOGENE TECHNOLOGY Co Ltd
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SHAANXI GIANT BIOGENE TECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents

Abstract

The invention relates to the field of medical/cosmetic apparatuses, and in particular relates to mouth mucosa repairing liquid containing human-like collagen, wherein the rapid transdermal absorption of the human-like collagen can be promoted. The mouth mucosa repairing liquid containing human-like collagen can be used for repairing the mouth mucosa in the medical/cosmetic field. The mouth mucosa repairing liquid contains the human-like collagen, Carbomer, glycerol, polysorbate-80 and water.

Description

A kind of Human-like Collagen oral mucosa repair liquid
Technical field
The present invention relates to Human-like Collagen dressing, be specifically related to the oral mucosa repair liquid comprising Human-like Collagen, belong to beauty treatment/medical instruments field.
Background technology
Human-like Collagen is (referring to the Chinese patent application prospectus CN1371919A) for sister-in-law's teaching inventive of the model by NW China university, therefore also referred to as Fan Shi recombined collagen or Fan Human-like Collagen (Fan ' sHuman-likeCollagen, FHLC).Human-like Collagen has three chains, triple-helix structure, is the recombined collagen of a kind of high-biocompatibility, is now widely used for medical treatment or beauty treatment fields.
On the other hand, when collagen protein casting product is repaired for such as oral mucosa, due to factors such as saliva of buccal cavity secretion, drinking-water, collagen protein can not long duration of action in position to be repaired, namely collagen protein can act on the time at position to be repaired is limited.From this angle, in order to improve the effect of collagen protein casting product, need the fireballing collagen protein casting product of Transdermal absorption badly.But regrettably, research so far is only all the transdermal absorption factor paying close attention to collagen protein, and does not pay close attention to the Transdermal absorption speed of collagen protein.
Summary of the invention
In view of the above-mentioned problems in the prior art, it is an object of the invention to provide a kind of repair liquid repaired for oral mucosa that Human-like Collagen rapid transdermal can be promoted to absorb.
Inventors etc. are through further investigation, the starting point is placed in the Transdermal absorption speed of the collagen protein being never concerned before this, found that: for the Human-like Collagen oral mucosa repair liquid formed by coordinating particular types, the adjuvant of special ratios in Human-like Collagen, the rapid transdermal that can promote Human-like Collagen absorbs, thus completing the present invention.
That is, the present invention is as follows.
1. a Human-like Collagen oral mucosa repair liquid, comprising:
2. the Human-like Collagen oral mucosa repair liquid according to item 1, it is used for oral mucosa reparation.
3. the Human-like Collagen oral mucosa repair liquid according to item 1 or 2, its treatment being used for oral mucositis and/or oral ulcer and/or prevention.
4. the purposes in the dressing that preparation is repaired for oral mucosa of the Human-like Collagen oral mucosa repair liquid according to any one of 1～3.
5. the Human-like Collagen oral mucosa repair liquid according to any one of 1～3 in preparation for the purposes in oral mucositis and/or the treatment of oral ulcer and/or the dressing of prevention.
6. a method for the Human-like Collagen oral mucosa repair liquid according to any one of preparation 1～5, the method includes:
Step A: preparing A phase, described A phase is made up of the carbomer of 0.001～0.2 weight %, the glycerol of 3～15 weight % and the water of surplus；
Step B: prepare B phase, described B phase is Human-like Collagen liquid, it comprises so that the Human-like Collagen that content is 0.01～1 weight % of Human-like Collagen in described Human-like Collagen oral mucosa repair liquid, medium is water, and the weight ratio of described Human-like Collagen and described water is 1:1～20；
Step C: preparing C phase, described C phase is the polysorbate80 of 0.01～1 weight %；And
Step D: described B is added in described A phase, and heat to 80～85 DEG C, it is incubated 20～60 minutes, is then cooled to 50～60 DEG C, add described C phase, after stirring, be cooled to room temperature；Using the gross weight of described Human-like Collagen oral mucosa repair liquid as 100 weight %.
7. the method according to item 6, wherein, described A phase is by being added to the water after carbomer dispersion with glycerol, and stirs and prepare to being completely dissolved.
The present invention achieves techniques below effect: when the Human-like Collagen oral mucosa repair liquid of the present invention is applied to skin so that the Transdermal absorption speed of Human-like Collagen is accelerated, and 30 minutes transdermal absorption factors of Human-like Collagen significantly improve.Thus, the Human-like Collagen oral mucosa repair liquid of the present invention can provide better nourishing, stimulates oral mucosa cell regeneration, promotes the reparation of damaged oral mucosa.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention will be described in detail.
The present invention provides a kind of Human-like Collagen oral mucosa repair liquid, comprising:
In this manual, Human-like Collagen refers to the recombined collagen described in claim 1 of the open CN1371919A of Chinese patent application, it has three chains, triple-helix structure, and it can adopt the gene engineering expression method disclosed in the open CN1371919A of such as this Chinese patent application to prepare.Human-like Collagen be the model by NW China university for sister-in-law's teaching inventive, therefore also referred to as Fan Shi recombined collagen or Fan Human-like Collagen (Fan ' sHuman-likeCollagen, FHLC).
Carbomer is the acrylic acid high molecular polymer with allyl sucrose or Allyl pentaerythritol ether of synthesis.Described carbomer is not particularly limited, it is possible to use those carbomers that those skilled in the art generally use in cosmetics or medical dressing, for instance the carbomer that Guangzhou Concho Hampshire Pharmaceutical Co., Ltd produces, CASNo:9003-01-4 can be used.
Described glycerol is not particularly limited, it is possible to use those glycerol that those skilled in the art generally use in cosmetics or medical dressing, for instance the glycerol that Hu'nan Erkang Pharmaceutical Co., Ltd. produces, CASNo:56-81-5 can be used.
Described polysorbate80 is not particularly limited, those polysorbate80s that those skilled in the art generally use in cosmetics or medical dressing can be used, such as can use the polysorbate80 that Hu'nan Erkang Pharmaceutical Co., Ltd. produces, CASNo:9005-65-6.
When the Human-like Collagen oral mucosa repair liquid of the present invention is applied to skin so that the Transdermal absorption speed of Human-like Collagen is accelerated, and 30 minutes transdermal absorption factors of Human-like Collagen significantly improve, and its reason is likely due to constitute suitable microenvironment.
Therefore, the Human-like Collagen oral mucosa repair liquid of the present invention is particularly suitable at medical treatment/beauty treatment fields for oral mucosa reparation.Here, the breakage of oral mucosa is probably stomatitis or what oral ulcer caused, and therefore, the Human-like Collagen oral mucosa repair liquid of the present invention can be used for treatment and/or the prevention of stomatitis or oral ulcer.When the oral mucosa for medical treatment/beauty treatment fields repairs purposes, the Human-like Collagen oral mucosa repair liquid of the present invention can use as dressing itself, it is also possible to makes other kinds of dressing with other carriers or auxiliary material combination again.
Preparation method for the Human-like Collagen oral mucosa repair liquid of the present invention is not particularly limited, and common preparation method may include that
Step A: preparing A phase, described A phase is made up of the carbomer of 0.001～0.2 weight %, the glycerol of 3～15 weight % and the water of surplus；
Step B: prepare B phase, described B phase is Human-like Collagen liquid, it comprises so that the Human-like Collagen that content is 0.01～1 weight % of Human-like Collagen in described Human-like Collagen oral mucosa repair liquid, medium is water, and the weight ratio of described Human-like Collagen and described water is 1:1～20；
Step C: preparing C phase, described C phase is the polysorbate80 of 0.01～1 weight %；And
Step D: described B is added in described A phase, and heat to 80～85 DEG C, it is incubated 20～60 minutes, is then cooled to 50～60 DEG C, add described C phase, after stirring, be cooled to room temperature；
Using the gross weight of described Human-like Collagen oral mucosa repair liquid as 100 weight %.
Here, Human-like Collagen liquid includes the aqueous solution of Human-like Collagen and the aqueous dispersions of Human-like Collagen.
Here, the order of described step A, B, C is not particularly limited, it is possible to successively carry out with random order or carry out simultaneously.
Preferably, described A phase is by being added to the water after carbomer dispersion with glycerol, and stirs and prepare to being completely dissolved.
Here, the mode for stirring is not particularly limited, as long as can stir.
The Human-like Collagen oral mucosa repair liquid of the present invention can be placed in packing container.The material constituting packing container is not particularly limited, and it includes but not limited to pottery, glass, metal, plastics etc..Packing container can airtight can not also be airtight, but preferably airtight.
Embodiment
Hereinafter, by embodiment, the present invention is carried out more specific description, but the present invention is not restricted by the embodiments.
The Human-like Collagen used in following embodiment and comparative example is the Fan Human-like Collagen (aminoacid sequence shown in SEQIDNO:1 forms) prepared by method described in the open CN1371919A of Chinese patent application, confirms that its molecular weight is 90kDa.
In order to observe the Transdermal absorption behavior of Human-like Collagen, adopt conventional method FITC (fluoresceinisothiocyanate, Fluorescein isothiocyanate) that it has been carried out fluorescent labeling.
If no special instructions, " % " in the description below refers to " weight % ".
The preparation of the Human-like Collagen oral mucosa repair liquid of embodiment 1. present invention
Composition: carbomer 0.02%, glycerol 6%, Human-like Collagen 0.5%, polysorbate80 0.1%, water 93.38%.
Technological operation:
1. first carbomer is added to the water, is stirred continuously to being completely dispersed out after being then slowly added into glycerol.Being subsequently added Human-like Collagen aqueous solution (10 weight %), stirring while adding to being completely dissolved, heating, to 80-85 DEG C, is incubated 30min；
2. above-mentioned mixed liquor is cooled to 50-60 DEG C, adds polysorbate80, after stirring, be cooled to room temperature.
The preparation of other Human-like Collagen oral mucosa repair liquid of comparative example 1.
Composition: carbomer 0.5%, glycerol 2.5%, Human-like Collagen 0.5%, polysorbate80 1.5%, water 95%.
Technological operation:
1. first carbomer is added to the water, is stirred continuously to being completely dispersed out after being then slowly added into glycerol.Being subsequently added Human-like Collagen aqueous solution (10 weight %), stirring while adding to being completely dissolved, heating, to 80-85 DEG C, is incubated 30min；
2. above-mentioned mixed liquor is cooled to 50-60 DEG C, adds polysorbate80, after stirring, be cooled to room temperature.
The mensuration of 30 minutes transdermal absorption factors of collagen protein
Carry losing hair or feathers adapting to the mice of feeding environment at laboratory preserved skin with depilatory the previous day.Bath gel or cleansing milk is used preserved skin place to carry out skin clean and towels off dry before experiment, by the Human-like Collagen oral mucosa repair liquid of above-described embodiment and comparative example, preserved skin place of the same area is spread upon with equal amount respectively with medical cotton stick, normal raising after having smeared, when 0.5h by each group of mice 5 only with clear water by clean for preserved skin place Irrigation, adopting fluorescence microplate reader that the collagen protein in cleanout fluid is carried out quantitative analysis, it is just the failure to the collagen protein of transdermal.
Wherein, skin permeation rate so calculates: the collagen protein total amount of skin permeation rate=(the collagen protein amount of the collagen protein total amount smeared-fail transdermal)/smear.
For the Human-like Collagen oral mucosa repair liquid of embodiment and comparative example, the meansigma methods of above-mentioned skin permeation rate test result respectively 45% and 29%.
Also, it should be noted can implement and under the premise of the inconspicuous purport running counter to the present invention, the combination constituting the described any technology feature of part or technical characteristic as a certain technical scheme is readily adaptable for use in other technical scheme equally in this manual；Further, can implement and under the premise of the inconspicuous purport running counter to the present invention, can also be combined in any way between the technical characteristic that part is described as constituting of different technologies scheme, constitute other technical scheme.The present invention is also contained in above-mentioned situation the technical scheme obtained by combining, and these technical schemes are equivalent to record in this manual.
Describing the present invention above by detailed description of the invention and embodiment, but it will be understood by those skilled in the art that these are not intended to the scope of the present invention is defined, the scope of the present invention should be determined by claims.
Industrial applicibility
The Human-like Collagen oral mucosa repair liquid of the present invention can significantly improve the Transdermal absorption speed of Human-like Collagen.

Claims (7)

1. a Human-like Collagen oral mucosa repair liquid, comprising:
2. Human-like Collagen oral mucosa repair liquid according to claim 1, it is used for oral mucosa reparation.
3. Human-like Collagen oral mucosa repair liquid according to claim 1 and 2, its treatment being used for oral mucositis and/or oral ulcer and/or prevention.
4. the purposes in the dressing that preparation is repaired for oral mucosa of the Human-like Collagen oral mucosa repair liquid according to any one of claims 1 to 3.
5. the Human-like Collagen oral mucosa repair liquid according to any one of claims 1 to 3 is used for the purposes in oral mucositis and/or the treatment of oral ulcer and/or the dressing of prevention in preparation.
6. the method preparing Human-like Collagen oral mucosa repair liquid according to any one of Claims 1 to 5, the method includes:
Step A: preparing A phase, described A phase is made up of the carbomer of 0.001～0.2 weight %, the glycerol of 3～15 weight % and the water of surplus；
Step B: prepare B phase, described B phase is Human-like Collagen liquid, it comprises so that the Human-like Collagen that content is 0.01～1 weight % of Human-like Collagen in described Human-like Collagen oral mucosa repair liquid, medium is water, and the weight ratio of described Human-like Collagen and described water is 1:1～20；
Step C: preparing C phase, described C phase is the polysorbate80 of 0.01～1 weight %；And
Step D: described B is added in described A phase, and heat to 80～85 DEG C, it is incubated 20～60 minutes, is then cooled to 50～60 DEG C, add described C phase, after stirring, be cooled to room temperature；Using the gross weight of described Human-like Collagen oral mucosa repair liquid as 100 weight %.
7. method according to claim 6, wherein, described A phase is by being added to the water after carbomer dispersion with glycerol, and stirs and prepare to being completely dissolved.
CN201510883488.1A 2015-12-04 2015-12-04 A kind of human-like collagen oral mucosa reparation liquid Active CN105709216B (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106492267A (en) * 2016-11-25 2017-03-15 陕西巨子生物技术有限公司 A kind of Human-like Collagen anorectal Mucous rehabilitation gel
CN106902381A (en) * 2017-03-23 2017-06-30 陕西慧康生物科技有限责任公司 Recombination human source collagen stoste, dressing and their preparation method
CN108813631A (en) * 2018-04-27 2018-11-16 西安巨子生物基因技术股份有限公司 Human-like collagen oral solution and preparation method thereof
CN110787288A (en) * 2019-12-25 2020-02-14 郑州康金瑞健康产业有限公司 Medical collagen oral ulcer protective gel and preparation method thereof

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CN202409547U (en) * 2011-10-26 2012-09-05 陕西巨子生物技术有限公司 Collagen dressing

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106492267A (en) * 2016-11-25 2017-03-15 陕西巨子生物技术有限公司 A kind of Human-like Collagen anorectal Mucous rehabilitation gel
CN106902381A (en) * 2017-03-23 2017-06-30 陕西慧康生物科技有限责任公司 Recombination human source collagen stoste, dressing and their preparation method
CN106902381B (en) * 2017-03-23 2020-07-21 陕西慧康生物科技有限责任公司 Recombinant human collagen stock solution, dressing and preparation method thereof
CN108813631A (en) * 2018-04-27 2018-11-16 西安巨子生物基因技术股份有限公司 Human-like collagen oral solution and preparation method thereof
CN110787288A (en) * 2019-12-25 2020-02-14 郑州康金瑞健康产业有限公司 Medical collagen oral ulcer protective gel and preparation method thereof

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