CN202409547U - Collagen dressing - Google Patents
Collagen dressing Download PDFInfo
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- CN202409547U CN202409547U CN2011204139689U CN201120413968U CN202409547U CN 202409547 U CN202409547 U CN 202409547U CN 2011204139689 U CN2011204139689 U CN 2011204139689U CN 201120413968 U CN201120413968 U CN 201120413968U CN 202409547 U CN202409547 U CN 202409547U
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Abstract
The utility model relates to the field of medical or cosmetic products, in particular to collagen dressing. The collagen dressing is provided with a layered structure, and when the collagen dressing is stored and used, collagen liquid is not easy to dry up, and collagen is high in skin absorptivity and fine in comfortableness.
Description
Technical field
This utility model relates to the cosmetics field, is specifically related to a kind of collagen protein dressing.
Background technology
On present medical instruments field and the cosmetics market, the raw material that sticks series products is mainly fibres such as non-woven fabrics, directly contacting skin use behind the materials such as an infiltration maintenance type stock solution, essence; Be generally single layer structure; The skin care products amount of film body storage itself is relatively limited, and skin care products is only by the of short duration absorption of epidermis, and contains a large amount of chemical preservatives in the skin care products; Zest is stronger, and irritated rate is higher.
The utility model content
Collagen liquid was difficult for dry collagen protein dressing when the purpose of this utility model provided a kind of preservation and use.
In addition, another purpose of this utility model provides the high and good collagen protein dressing of comfortableness of a kind of skin absorbs rate.
That is, this utility model is following.
1. collagen protein dressing, it comprises collagen protein, it is characterized in that:
This collagen protein dressing has layer structure;
At least layer of non-woven fabric layer is set in the layered structure, and this nonwoven layer is soaked into collagen liquid;
The upper and lower both sides of said nonwoven layer are respectively the collagen protein liquid layer;
The outermost layer of layered structure is the packing container layer;
Said packing container layer forms packing container, and said nonwoven layer and said collagen protein liquid layer are accommodated in wherein.
2. according to item 1 described collagen protein dressing, it is characterized in that: said collagen liquid is a Fan Shi Human-like Collagen liquid.
3. according to item 1 or 2 described collagen protein dressing, it is characterized in that: described nonwoven layer is one deck.
4. according to item 3 described collagen protein dressing, it is characterized in that: a side of described nonwoven layer is provided with the corresponding with it pearly-lustre rete of shape.
5. according to item 1 or 2 described collagen protein dressing, it is characterized in that: described nonwoven layer be two-layer more than.
6. according to item 5 described collagen protein dressing, it is characterized in that: have at least to be provided with the corresponding with it pearly-lustre rete of shape between the two-layer nonwoven layer.
7. according to item 1 described collagen protein dressing, it is characterized in that: said collagen protein liquid layer interconnects in the edge of nonwoven layer.
8. according to item 1 described collagen protein dressing, it is characterized in that: described packing container layer is three shape structures layer by layer, and outermost layer is oriented polypropylene (OPP) layer, PETG layer or layers of kraft paper; The intermediate layer is aluminum layer, aluminium coated or negative and positive aluminium coated; Innermost layer is polyethylene layer, polychlorostyrene pvdf layer or cast polypropylene layer.
9. according to item 1 described collagen protein dressing, it is characterized in that: described packing container layer is four shape structures layer by layer, and outermost layer is oriented polypropylene (OPP) layer, PETG layer or layers of kraft paper; The second layer is an aramid layer; The 3rd layer is aluminum layer, aluminium coated or negative and positive aluminium coated; Innermost layer is polyethylene layer, polychlorostyrene pvdf layer or cast polypropylene layer.
10. according to item 1 described collagen protein dressing, it is characterized in that: described nonwoven layer is provided with the incomplete opening of open-type of eye, nose and mouth; The edge of nonwoven layer is provided with and regulates mouth.
The utlity model has following advantage: the collagen protein dressing of this utility model has adopted multiple structure; And infiltration collagen liquid; The interpolation of restriction antiseptic; Not only effectively improved the storage capacity of film body, increased the trap of skin, also reduced the zest and the irritated rate of dressing stock solution.
Description of drawings
Fig. 1 is the outside vertical view of this utility model.
Fig. 2 is the vertical view of nonwoven layer of the dressing of this utility model.
Fig. 3 is the A-A sectional view of the dressing of single-layer nonwoven structure.
Fig. 4 is the A-A sectional view of the dressing of two-layer nonwoven structure.
Symbol description
1-packing container layer, 2-collagen protein liquid layer, the 3-nonwoven layer, 4-regulates mouth, 5-pearly-lustre rete.
The specific embodiment
Below in conjunction with the specific embodiment this utility model is carried out detailed explanation.
In the human body skin composition, to form by collagen protein by 70%-80%, external collagen protein series products can play tangible reparation and maintenance effect to skin.
This utility model provides a kind of collagen protein dressing, and it comprises collagen protein, it is characterized in that:
This collagen protein dressing has layer structure;
At least layer of non-woven fabric layer 3 is set in the layered structure, and this nonwoven layer 3 is soaked into collagen liquid;
The upper and lower both sides of said nonwoven layer 3 are respectively collagen protein liquid layer 2;
The outermost layer of layered structure is a packing container layer 1;
Said packing container layer 1 forms packing container, and said nonwoven layer 3 is accommodated in wherein with said collagen protein liquid layer 2.
Here, when said outermost layer is meant the collagen protein dressing horizontal positioned of this utility model, is positioned at uppermost layer and is positioned at nethermost layer.
Here, collagen protein comprises the collagen protein (the for example collagen protein of animal origin) of natural origin, also comprises collagen derivative and collagen protein analog, is preferably the collagen protein of natural origin.Collagen liquid is a prior art, can be about the preparation of collagen liquid referring to for example referring to works " collagen and collagen protein ", and Jiang Tingda writes, Chemical Industry Press, publish in March, 2006.
Preferably, said collagen liquid is a Fan Shi Human-like Collagen liquid.Can be about Fan Shi Human-like Collagen (Fan ' s Human-like Collagen) and Fan Shi Human-like Collagen liquid referring to the for example one Chinese patent application 201110327873.X number (applying date: on October 26th, 2011, denomination of invention: recombined collagen).For traditional collagen protein such as gelatin, though its good biocompatibility because its Transdermal absorption performance is bad, therefore, it is generally acknowledged that the cosmetic result of collagen protein is still waiting to improve, particularly its nourishing effect to skin corium is limited.Yet the inventor finds: find that the Fan Shi Human-like Collagen has the Transdermal absorption performance that significantly is superior to traditional collagen protein, thereby the dressing that comprises this collagen protein has the medical cosmetology effect of remarkable excellence.
One preferred embodiment in; This utility model soaks into nonwoven layer 3 with collagen liquid as infiltrate; Process collagen protein dressing, a side is provided with the corresponding with it pearly-lustre rete 5 of shape, places the packing container layer 1 of multiple structure; The upper and lower both sides of nonwoven layer 3 all are full of collagen liquid in the packing container layer 1, and collagen protein liquid layer 2 interconnects in nonwoven layer 3 edges.Nonwoven layer 3 can be provided with one or more layers, as is arranged to soak into collagen liquid respectively when two-layer, and the both sides up and down of every layer of nonwoven layer 3 all are full of collagen protein liquid layer 2, and the corresponding pearly-lustre rete 5 of shape with it is set between the two-layer nonwoven layer 3.Being provided with of multi-layer nonwoven fabrics layer 3 can increase the memory space of facial film to collagen liquid.
One preferred embodiment in, packing container layer 1 can be arranged to three shape structures layer by layer, outermost layer is oriented polypropylene (OPP) layer, PETG layer or layers of kraft paper, is beneficial to printing; The intermediate layer is aluminum layer, aluminium coated or negative and positive aluminium coated, and its non-oxygen permeability makes packing play good iris action, prevents that collagen liquid from being polluted; Innermost layer is polyethylene layer, polychlorostyrene pvdf layer or cast polypropylene layer, can prevent that collagen liquid from directly contacting with the aluminium-containing substance in intermediate layer, and have good thermostability, keeps better stability in the heat sterilization link in process of production.Packing container layer 1 also can be arranged to four shape structures layer by layer, and outermost layer is oriented polypropylene (OPP) layer, PETG layer, DOTP layer or layers of kraft paper; The second layer is an aramid layer, can strengthen the barrier of packing; The 3rd layer is aluminum layer, aluminium coated or negative and positive aluminium coated; Innermost layer is polyethylene layer, polychlorostyrene pvdf layer or cast polypropylene layer.
One preferred embodiment in; The non-anticorrosion type of material that has added antiseptic in the collagen liquid or had antisepsis; Antiseptic is specially one or more in imidazolidinyl urea, two imidazolidinyl urea, potassium sorbate, sodium benzoate, methyl hydroxybenzoate, ethyl ester, propyl ester or the butyl ester, and parts by weight are 100,000 of collagen liquid total amount/to 5/10000ths; Non-anticorrosion type of material is specially one or more in propylene glycol, butanediol, pentanediol, hexanediol or the ethohexadiol, and parts by weight are the one thousandth to percent eight of collagen liquid total amount.The use of non-anticorrosion type of material can reduce zest and irritated rate that product uses effectively.
One preferred embodiment in, added correctives in the collagen liquid, be specially in vanilla flavor, Aloe spice, rose or the fruit flavor one or more, parts by weight are 100,000 of collagen liquid total amount/to one of percentage.
One preferred embodiment in, nonwoven layer 3 is provided with the incomplete opening of open-type of eye, nose and mouth, can nurse and maintain the skin of eye, nose and mouth in the lump during use.For Face film towel, can its part corresponding to eye, nose and/or mouth be removed promptly complete opening; Also can on above-mentioned position, form aperture lines, also make corresponding part to open, be i.e. the incomplete opening of open-type.
One preferred embodiment in, the edge of nonwoven layer 3 is provided with and regulates mouthfuls 4, the angle of coverage of the area coverage of scalable facial film when sticking facial film increases the applying degree.Said adjusting mouth 4 is formed in the locational aperture lines corresponding to facial edge of Face film towel, helps Face film towel and is close to face.
Nonwoven layer 3 also can be arranged to other different shapes, with applying cervical region, chest, abdominal part, foot or hand etc., can be used as uses such as cervacoria, pleura, peritoneum, hands film and foot film.
Embodiment
Below, through embodiment this utility model is explained more specifically, but this utility model does not receive the restriction of these embodiment.
The preparation of embodiment 1 Fan Shi Human-like Collagen
Prepared Fan Shi Human-like Collagen (aminoacid sequence by shown in the SEQ ID NO:1 is formed) by the open said method of CN1371919A of one Chinese patent application, confirmed that its molecular weight is about 90kDa.
The Transdermal absorption behavioral study of embodiment 2 Fan Shi Human-like Collagens
Laboratory animal and grouping:
8 the week age Kunming white mice (20～30g) 20 of body weight, male and female are not limit.Laboratory mice is divided into two groups at random, 10 of Fan Shi Human-like Collagen groups, 10 of gelatin groups.
The reagent preparation:
Accurately take by weighing 0.3g Fan Shi Human-like Collagen in beaker, to wherein adding ultra-pure water, and fully stir with Glass rod albumen is dissolved fully until 30ml.Accurately take by weighing 15mgFITC (fluorescein isothiocyanate, Fluorescein isothiocyanate) again, be dissolved in the pH9.0 carbonic acid buffer of 30ml, make it with the Glass rod stirring and fully dissolve (concentration is 0.5mg/ml).The FITC solution that the 30ml dissolving is good joins in the good Fan Shi Human-like Collagen solution of above-mentioned 30ml dissolving, makes its abundant mixing, 4 ℃ of lucifuge reaction 24h.Reaction is poured in the bag filter that molecular cut off is 8000-10000 after finishing, and bag filter is fixed in the large beaker, in large beaker, adds the solution of PBS buffer in the submergence bag filter.Large beaker is placed on begins to stir dialysis on the magnetic stirring apparatus, dialysis beginning back is every changes a buffer at a distance from 30min, and the FITC of dialysis on liquid chromatographic detection is uncrosslinked all removes.The solution that dialysis is the good low-temperature dark of packing in the vial is preserved subsequent usely, and the concentration of the Fan Shi Human-like Collagen that be labeled this moment is counted about 5g/100ml with the Fan Shi Human-like Collagen.
On the other hand, accurately take by weighing the 0.3g gelatin in beaker, to wherein adding ultra-pure water 30ml.Beaker sealed with preservative film put into the low fire heating of microwave oven and gelatin was fully dissolved in 4 minutes.The labeling method of Tong Fanshi Human-like Collagen is prepared the FITC solution 30ml of 0.5mg/ml, this 30ml FITC solution is joined make its abundant mixing in the above-mentioned 30ml gelatin solution, 4 ℃ of lucifuges reaction 24h.Reaction is poured in the bag filter that molecular cut off is 8000-10000 dialysis process Tong Fanshi Human-like Collagen into after finishing.The solution that dialysis is the good low-temperature dark of packing in the vial is preserved subsequent use.The concentration of the gelatin that this is labeled is counted about 5g/100ml with gelatin.
Experimental technique:
The mice that adapts to feeding environment at laboratory is carried the previous day with the depilatory preserved skin that loses hair or feathers.Use bath gel or cleansing milk that the preserved skin place is carried out skin clean and towels off dried before the experiment; The Fan Shi Human-like Collagen solution that above-mentioned labelling is accomplished and gelatin solution spread upon the preserved skin place with medical cotton stick respectively as dressing, smear accomplish after normal raising; When 4h, 8h, each 5 of mice of group is cleaned up preserved skin place skin with clear water; Put to death after cleaning finishes, the skin of smearing Fan Shi Human-like Collagen solution and gelatin solution is cut with operating scissors rapidly, frozen section is carried out in the embedding of embedding medium low temperature; Use fluorescence microscope under ultraviolet excitation, to observe after frozen section is accomplished, and take pictures and do experimental record.
Can know that by above-mentioned experimental result traditional collagen protein is gone up basically and can not be got into skin corium; Relative therewith, the Fan Shi Human-like Collagen has the good transdermal absorbent properties, smears that its major part (about more than 80%) gets into skin corium behind the 8h.
Embodiment 3 collagen protein dressing preparation example
Collagen protein dressing (collagen protein face towel): get non-woven fabrics a slice (24cm*21cm), appearance requirement does not have spot, no broken hole, does not have and tear.Get one of unsealed medical Aluminium Foil Package pack, with above-mentioned non-woven fabrics doubling twice, in this medical Aluminium Foil Package pack of packing into then.To the Fan Shi of the 5g/100ml that wherein pours into appropriate amount Human-like Collagen liquid, make this non-woven fabrics soak into this Fan Shi Human-like Collagen liquid, and a small amount of residue is arranged again, make the collagen protein liquid layer interconnect in the edge of nonwoven layer.Then, said medical Aluminium Foil Package pack is sealed, promptly obtain collagen protein face towel.
Also need to prove; Can implement and the prerequisite of the not obvious purport of running counter to this utility model under, the combination as described arbitrary technical characterictic of the component part of a certain technical scheme or technical characterictic equally also goes for other technical scheme in this manual; And, can implement and the prerequisite of the not obvious purport of running counter to this utility model under, as also making up between the described technical characterictic of the component part of different technologies scheme, constitute other technical scheme with any-mode.This utility model is also contained in the technical scheme that obtains through combination under the above-mentioned situation, and these technical schemes are equivalent to record in this manual.
More than through the specific embodiment and embodiment this utility model is illustrated, but it will be understood by those skilled in the art that these are not intention the scope of this utility model is limited, the scope of this utility model should be confirmed by claims.
Industrial applicibility
The collagen protein dressing of this utility model can provide and be difficult for dry collagen protein cosmetics, the medical cosmetology product that perhaps has the medical cosmetology effect that significantly is superior to traditional collagen protein dressing.
Claims (10)
1. collagen protein dressing, it comprises collagen protein, it is characterized in that:
This collagen protein dressing has layer structure;
At least layer of non-woven fabric layer is set in the layered structure, and this nonwoven layer is soaked into collagen liquid;
The upper and lower both sides of said nonwoven layer are respectively the collagen protein liquid layer;
The outermost layer of layered structure is the packing container layer;
Said packing container layer forms packing container, and said nonwoven layer and said collagen protein liquid layer are accommodated in wherein.
2. collagen protein dressing according to claim 1 is characterized in that: said collagen liquid is a Fan Shi Human-like Collagen liquid.
3. collagen protein dressing according to claim 1 and 2 is characterized in that: described nonwoven layer is one deck.
4. collagen protein dressing according to claim 3 is characterized in that: a side of described nonwoven layer is provided with the corresponding with it pearly-lustre rete of shape.
5. collagen protein dressing according to claim 1 and 2 is characterized in that: described nonwoven layer be two-layer more than.
6. collagen protein dressing according to claim 5 is characterized in that: have at least to be provided with the corresponding with it pearly-lustre rete of shape between the two-layer nonwoven layer.
7. collagen protein dressing according to claim 1 is characterized in that: said collagen protein liquid layer interconnects in the edge of nonwoven layer.
8. collagen protein dressing according to claim 1 is characterized in that: described packing container layer is three shape structures layer by layer, and outermost layer is oriented polypropylene (OPP) layer, PETG layer or layers of kraft paper; The intermediate layer is aluminum layer, aluminium coated or negative and positive aluminium coated; Innermost layer is polyethylene layer, polychlorostyrene pvdf layer or cast polypropylene layer.
9. collagen protein dressing according to claim 1 is characterized in that: described packing container layer is four shape structures layer by layer, and outermost layer is oriented polypropylene (OPP) layer, PETG layer or layers of kraft paper; The second layer is an aramid layer; The 3rd layer is aluminum layer, aluminium coated or negative and positive aluminium coated; Innermost layer is polyethylene layer, polychlorostyrene pvdf layer or cast polypropylene layer.
10. collagen protein dressing according to claim 1 is characterized in that: described nonwoven layer is provided with the incomplete opening of open-type of eye, nose and mouth; The edge of nonwoven layer is provided with and regulates mouth.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011204139689U CN202409547U (en) | 2011-10-26 | 2011-10-26 | Collagen dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011204139689U CN202409547U (en) | 2011-10-26 | 2011-10-26 | Collagen dressing |
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| Publication Number | Publication Date |
|---|---|
| CN202409547U true CN202409547U (en) | 2012-09-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011204139689U Ceased CN202409547U (en) | 2011-10-26 | 2011-10-26 | Collagen dressing |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103332404A (en) * | 2013-06-27 | 2013-10-02 | 苏州宝丽洁日化有限公司 | Microwave oven explosion wet tissue |
| CN105709216A (en) * | 2015-12-04 | 2016-06-29 | 陕西巨子生物技术有限公司 | Mouth mucosa repairing liquid containing human-like collagen |
| CN106309150A (en) * | 2015-06-29 | 2017-01-11 | 山东国际生物科技园发展有限公司 | Medical collagen dressing, and preparation method and applications thereof |
-
2011
- 2011-10-26 CN CN2011204139689U patent/CN202409547U/en not_active Ceased
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103332404A (en) * | 2013-06-27 | 2013-10-02 | 苏州宝丽洁日化有限公司 | Microwave oven explosion wet tissue |
| CN106309150A (en) * | 2015-06-29 | 2017-01-11 | 山东国际生物科技园发展有限公司 | Medical collagen dressing, and preparation method and applications thereof |
| CN105709216A (en) * | 2015-12-04 | 2016-06-29 | 陕西巨子生物技术有限公司 | Mouth mucosa repairing liquid containing human-like collagen |
| CN105709216B (en) * | 2015-12-04 | 2019-03-12 | 陕西巨子生物技术有限公司 | A kind of human-like collagen oral mucosa reparation liquid |
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Legal Events
| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C35 | Partial or whole invalidation of patent or utility model | ||
| IW01 | Full invalidation of patent right |
Decision date of declaring invalidation: 20140121 Decision number of declaring invalidation: 21993 Granted publication date: 20120905 |