CN107007823B - Medicine for treating rhinitis and preparation method thereof - Google Patents
Medicine for treating rhinitis and preparation method thereof Download PDFInfo
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- CN107007823B CN107007823B CN201710422828.XA CN201710422828A CN107007823B CN 107007823 B CN107007823 B CN 107007823B CN 201710422828 A CN201710422828 A CN 201710422828A CN 107007823 B CN107007823 B CN 107007823B
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- nacl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Abstract
A medicament for treating rhinitis and its preparation method, in the field of medicament, in order to provide a medicament that can completely cure rhinitis, the technical scheme of the invention is as follows: the invention relates to a medicine for treating rhinitis, which comprises NaCl and fish skin collagen, wherein the weight ratio of the NaCl to the fish skin collagen is 10:1, and the medicine has the beneficial effects that: 1. the raw materials of the medicine are easily available, are food-grade raw materials, have no irritation, and are safe and reliable; 2. the preparation process is simple and easy to prepare.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to a medicine for treating rhinitis and a preparation method thereof.
Background
Rhinitis is a common frequently-occurring disease, has no harm to life, can cause dizziness and discomfort of the whole body due to stuffy nose, stuffy nose and no dryness of nasal discharge, and seriously affects the work, study and life quality of people. According to the statistics of relevant departments, about 1 hundred million nasal diseases such as chronic rhinitis, allergic rhinitis, nasosinusitis and the like exist in the country, wherein the number of teenagers accounts for 6800 ten thousand, and the serious rhinitis can possibly cause nasopharyngeal carcinoma.
Various medicines for treating rhinitis on the market are called stranguria and enamel, but no medicines for killing nasal cavity bacteria and expanding micro-vessels exist, the medicines are used for one time, the medicines are stopped and recur, the patient feels no idea, and no rhinitis medicine for repairing nasal mucosa is found, so that the problem is solved.
Therefore, it is necessary to provide a medicine for radically treating rhinitis.
Disclosure of Invention
In order to solve the above mentioned problems, the invention provides a drug which can repair nasal mucosa and radically cure rhinitis, and in order to achieve the purpose, the technical scheme of the invention is as follows:
the inventor finds that only the fish skin collagen is not enough to achieve the curative effect, the effect of curing the rhinitis can be achieved only by simultaneously using the NaCl and the fish skin collagen in a ratio of 10:1, high-quality sodium chloride kills various harmful bacteria in the nasal cavity, including stubborn mildew, the fish skin collagen can repair damaged mucosa, the NaCl and the fish skin collagen interact with each other, and the rhinitis can be effectively and thoroughly cured.
Furthermore, the fish skin collagen is extracted from tilapia mossambica, and tilapia mossambica is an easily available food, safe and reliable, and has a wide source.
Furthermore, the molecular weight of the fish skin collagen is lower than 3000 daltons, the low molecular weight is more favorable for the absorption of the fish skin collagen, and the repairing effect is better.
Further, the Nacl is AR-grade Nacl.
The preparation method of the medicine for treating rhinitis is characterized by comprising the following steps:
(1) preparing a nasal mucosa repair factor, namely taking fresh tilapia skin, putting the skin into a flask, adding 0.01 mol/L hydrochloric acid solution, adding 1000ml hydrochloric acid solution into every 600g of the skin, heating and refluxing until the reaction solution is transparent colloid solution, removing a heat source, adding 0.05 mol/L NaoH solution to adjust the pH value to 4.8 +/-0.1 when the temperature of the solution is reduced to 43-48 ℃, so that the solution is turbid and flocculent precipitate exists, filtering, discarding filtrate, washing filter cakes with ionized water, and drying at 58-62 ℃ to obtain white-like colloid protein powder, namely the nasal mucosa repair factor;
(2) the preparation of the medicine comprises the steps of weighing NaCl and the nasal mucosa repair factor according to the weight ratio of 10:1, putting the Nacl and the nasal mucosa repair factor into a beaker, adding ionized water to prepare a solution containing 275 g/L g of NaCl and gelatin-derived protein powder, stirring the solution into a transparent solution, filtering the transparent solution by using a glass sand core, collecting filtrate, and sterilizing the filtrate to obtain the medicine.
The invention has the beneficial effects that: 1. the raw materials of the medicine are easily available, are food-grade raw materials, have no irritation, and are safe and reliable; 2. the preparation process is simple and easy to prepare.
Detailed Description
The present invention will be further described below.
Example 1
1. Preparation of the nasal mucosa repair factor:
taking 5000g of fresh tilapia, only taking fish skin to obtain about 600g of fish skin, placing the fish skin into a 2000M L three-neck flask, adding 1000M L0.01.01 mol/L hydrochloric acid solution, heating, refluxing for 6 hours to enable reaction liquid to be transparent colloid liquid, stopping heating, cooling the liquid to about 45 ℃, slowly adding 0.05 mol/L NaoH solution, adjusting the pH value to 4.8 +/-0.1 to enable the solution to be turbid and have floccule precipitate, filtering, discarding filtrate, adding a small amount of ionized water for spray washing filter cakes, pumping to obtain wet matters, drying the wet matters at 60 ℃, obtaining about 100g of white colloid source protein powder, and obtaining the nasal mucosa repair factor.
2. Weighing 250g of NaCl and 25g of nasal mucosa repair factor accurately according to the prescription, adding into a 2000ml wide-mouth beaker, adding ionized water, fully stirring to obtain 1000ml of transparent solution, filtering with a No. 3 glass sand core, collecting filtrate, filling the filtrate into a 15ml glass bottle, and sterilizing at 100 ℃ for 20 minutes to obtain the medicine for treating rhinitis.
Example 2
1. Preparation of the nasal mucosa repair factor:
taking 5000g of fresh tilapia, only taking fish skin, obtaining about 600g of fish skin, placing the fish skin into a 2000M L three-neck flask, adding 1000M L0.01.01 mol/L hydrochloric acid solution, heating, refluxing for 7 hours to enable reaction liquid to be transparent colloid liquid, stopping heating, cooling the liquid to about 46 ℃, slowly adding 0.05 mol/L NaoH solution, adjusting the pH value to 4.8 +/-0.1 to enable the solution to be turbid and have floccule precipitate, filtering, discarding filtrate, adding a small amount of ionized water for washing a filter cake, pumping to obtain wet matter, drying the wet matter at 58-62 ℃ to obtain about 100g of white collagen powder, namely the nasal mucosa repair factor.
2. Weighing 250g of NaCl and 25g of nasal mucosa repair factor accurately according to the prescription, adding into a 2000ml wide-mouth beaker, adding ionized water, fully stirring to obtain 1000ml of transparent solution, filtering with a No. 3 glass sand core, collecting filtrate, filling the filtrate into a 15-20ml glass bottle, and sterilizing at 100 ℃ for 20 minutes to obtain the product.
Example 3
The raw materials used by the invention are all prepared from common food, and are prepared into an externally-used 'Bikangling' medicine, and the medicine is smeared on the skin of mice and rabbits without any abnormal expression, which indicates that the product is free from allergy and stimulation.
The product can be directly used by human body without toxicity and side effect, and has satisfactory effect. Starting from month 9 2012 to month 2 2017, a statistic of about 350 patients with various rhinitis patients for various age groups is compiled as follows:
nose health-care summary table for trial use
The medicine prepared by the application has the best treatment effect on the rhinitis of children, and is an excellent medicine for treating the rhinitis of children with more strict medication because the raw materials of the medicine are edible.
Example 4
The patients male, 8 years old and 4 years old, find that the rhinitis is infected, various rhinitis drugs are used, the symptoms are improved when the drug is used, and the symptoms reappear in two days after the drug is stopped. Then, a little liquid medicine is dipped in the Bikangling solution prepared by the method of the application and a cotton ball of absorbent medicine, and is plugged into nostrils, for convenience of ventilation, the two sides are plugged in turns for 3-5 times per day, symptoms are basically eliminated by only two days, the nasal Kangling solution is continuously used for two days, the nasal Kangling solution is cured, and the nasal Kangling solution has no recurrence for more than 4 years.
When a certain person in yellow is a male, the person is 43 years old, the person complains about rhinitis for nearly 20 years, various medicines are used, symptoms are improved when the medicine is used, but the symptoms appear in three days, the symptoms disappear after the medicine prepared by the application is used for later trial for three days, and the symptoms are more than two years till now, and the symptoms do not relapse.
A certain old man, 45 years old, complain of the disease for at least 20 years, cannot take effect after using various rhinitis medicines, a patient has no any confidence in the disease condition, the variety is introduced by a commenting on the deep office in the west and the river, the mood of trying one test is held, the first day is used, the nose is passed, the nasal discharge is not flowed, the joy is extremely high, the nasal discharge is continuously used for 7 days, and the patient is comprehensively recovered.
When a certain woman is aged for 81 years, the patient self-complains of nasosinusitis, the condition of the patient is over 30 years, the patient has nasal obstruction, rhinorrhoea and dizziness, and countless medicines are used, so that the problems cannot be solved, the symptoms are eliminated after the product is used for 10 days, but the symptoms are generated after more than ten days, and the medicine liquid is continuously used for 7 days, so that eight months exist till now, and no symptoms are generated. On happy land, thank you for the old and stubborn disease that she has been for more than thirty years. It can be seen that the shorter the age, the shorter the period of cure and the better the therapeutic effect.
Claims (3)
1. A preparation method of a medicine for treating rhinitis is characterized in that the medicine comprises NaCl and fish skin collagen, the weight ratio of the NaCl to the fish skin collagen is 10:1, and the fish skin collagen is extracted from tilapia;
the preparation method comprises the following steps:
(1) preparing a nasal mucosa repair factor, namely taking fresh tilapia skin, putting the skin into a flask, adding 0.01 mol/L hydrochloric acid solution, covering the skin, heating and refluxing until the reaction solution is transparent colloid solution, removing a heat source, adding 0.05 mol/L NaOH solution to adjust the pH value to 4.8 +/-0.1 when the temperature of the solution is reduced to 43-48 ℃, enabling the solution to be turbid and have flocculent precipitates, filtering, discarding filtrate, adding ionized water for washing, and drying at 58-62 ℃ to obtain white-like collagen powder;
(2) the preparation of the medicine comprises the steps of weighing NaCl and collagen powder according to the weight ratio of 10:1, putting the NaCl and collagen powder into a beaker, adding ionized water to prepare a solution containing NaCl and gelatin-derived protein powder 275 g/L, stirring the solution into a transparent solution, filtering the transparent solution by using a glass sand core, collecting filtrate, and sterilizing the filtrate to obtain the medicine.
2. The process for preparing a medicament as claimed in claim 1, wherein the fish skin collagen has a molecular weight of less than 3000 daltons.
3. The method of claim 1, wherein the NaCl is AR grade NaCl.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710168316 | 2017-03-21 | ||
| CN2017101683165 | 2017-03-21 |
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| Publication Number | Publication Date |
|---|---|
| CN107007823A CN107007823A (en) | 2017-08-04 |
| CN107007823B true CN107007823B (en) | 2020-07-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710422828.XA Active CN107007823B (en) | 2017-03-21 | 2017-06-07 | Medicine for treating rhinitis and preparation method thereof |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114452247A (en) * | 2022-03-11 | 2022-05-10 | 包头瑞象控股中心(有限合伙) | Rare earth washing liquor for rhinitis and preparation method thereof |
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| CN103989828A (en) * | 2014-05-21 | 2014-08-20 | 海南生态美生物科技有限公司 | Composition for promoting wound healing and preparation method thereof |
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2017
- 2017-06-07 CN CN201710422828.XA patent/CN107007823B/en active Active
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| CN104940994A (en) * | 2015-07-14 | 2015-09-30 | 江苏威克斯医疗科技有限公司 | Artificial nasal mucosa and application thereof |
| CN105709267A (en) * | 2015-12-04 | 2016-06-29 | 陕西巨子生物技术有限公司 | Mucosa-repairing gel containing human-like collagen |
| CN106491714A (en) * | 2016-11-10 | 2017-03-15 | 济宁沭康生物科技有限公司 | A kind of child's collunarium antibacterial liquid |
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| CN107007823A (en) | 2017-08-04 |
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