CN111643722A

CN111643722A - Sodium hyaluronate application containing icodextrin

Info

Publication number: CN111643722A
Application number: CN202010604192.2A
Authority: CN
Inventors: 杨效东; 王盈盈; 冯新光; 班文溥; 逄婧; 衣思闻
Original assignee: Qingdao Hua Rentang Health Science And Technology Ltd; Qingdao Huaren Medical Product Co ltd; Huaren Pharmaceutical Co Ltd; Huaren Pharmaceutical Rizhao Co Ltd
Current assignee: Qingdao Hua Rentang Health Science And Technology Ltd; Qingdao Huaren Medical Product Co ltd; Huaren Pharmaceutical Co Ltd; Huaren Pharmaceutical Rizhao Co Ltd
Priority date: 2020-06-29
Filing date: 2020-06-29
Publication date: 2020-09-11

Abstract

The invention provides a sodium hyaluronate adhesive dressing containing icodextrin, which comprises the following components in parts by mass: 0.008-0.05% of icodextrin, 0.05-0.1% of sodium hyaluronate, 3-6% of propylene glycol, 0.02-0.1% of chlorphenesin, 0.3-0.5% of phenoxyethanol, 0.1-0.5% of ethylhexylglycerin, 0.3-0.5% of 1, 2-hexanediol, 93-95% of purified water or water for injection and 0.001-0.005% of flavoring agent.

Description

Sodium hyaluronate application containing icodextrin

Technical Field

The invention belongs to the field of medical instruments, and particularly relates to a sodium hyaluronate adhesive dressing containing icodextrin.

Background

The sodium hyaluronate is mucopolysaccharide formed by alternately connecting glucuronic acid and N-acetylglucosamine serving as disaccharide units, and is widely present in tissues such as nerve tissues, skin dermis and the like; it is distributed in the cytoplasm and the intercellular substance of the organ, and plays a role in lubricating and nourishing the cells and the organelles contained therein.

The glucan is homotypic polysaccharide composed of glucose as monosaccharide, and is divided into alpha-glucan and beta-glucan, and each glucan is combined by multiple bond positions. Dextran has a long history in the western world as an active ingredient in skin care products. Families in many European and American countries are used to bath the infants with water soaked with oat to relieve and prevent eczema; the elderly are also used to wash their face with oat water in winter to relieve dry skin. This is mainly due to the fact that the substances extracted from oats contain vitamin E and glucan components, both of which have a certain repairing and protecting effect on the skin.

The alpha-glucan oligosaccharide is a product obtained by acting glucose transferase on maltose, the polymerization degree of the alpha-glucan oligosaccharide is 4-6 glucose units, the molecular weight of the alpha-glucan oligosaccharide is small, and the alpha-glucan oligosaccharide is mainly used for moisturizing. However, the alpha-glucan oligosaccharide has a small molecular weight, cannot form an effective protective film on the skin surface, and has a weak protective effect.

Icodextrin is dextran prepared by hydrolyzing starch, has molecular weight of 19000-25000 dalton, and has good water solubility, safety and biocompatibility. The pharmaceutical preparation taking the icodextrin as the raw material is approved to be on the market in more than 30 countries and regions, and has good safety, biocompatibility and stability; the colloidal solution prepared from the icodextrin has good ultrafiltration effect and hydration floating effect, can be used as peritoneal dialysis solution and surgical anti-adhesion flushing solution, and Cooker shows that the icodextrin has good biocompatibility in a paper published in 2002; the paper published by Mistry in 1994 shows that icodextrin solutions proved safe and effective for long-term use as peritoneal dialysis solutions in a randomized multicenter clinical trial; the patent paper published by Catena in 2012 indicated that in a single-center, prospective randomized trial, the use of 4% icodextrin was safe in patients with small intestinal obstruction, reducing the risk of intra-abdominal adhesions forming and reoccluding.

In the process of studying icodextrin, we find that the colloidal solution formed by icodextrin has the efficacy of protection, which is probably because the icodextrin solution is the colloidal solution, an effective protective film can be formed on the surface of skin, the external pollution and the invasion of harmful bacteria are prevented, and a better protective effect is achieved on the affected part.

However, sodium hyaluronate has the highest moisture absorption capacity under low relative humidity (33%) and the lowest moisture absorption capacity under high relative humidity (75%), so that the sodium hyaluronate product has good effect only in fixed seasons and regions, the effect cannot be satisfied by consumers, and the use of sodium hyaluronate is limited.

Disclosure of Invention

In order to solve the problems, the invention provides a sodium hyaluronate adhesive dressing containing icodextrin, which comprises the following components in percentage by weight: the pasting dressing comprises the following components in parts by mass: 0.008-0.05% of icodextrin, 0.05-0.1% of sodium hyaluronate, 3-6% of propylene glycol, 0.02-0.1% of chlorphenesin, 0.3-0.5% of phenoxyethanol, 0.1-0.5% of ethylhexyl glycerol, 0.3-0.5% of 1, 2-hexanediol, 93-95% of purified water or water for injection and 0.001-0.005% of flavoring agent.

The sodium hyaluronate adhesive dressing containing the icodextrin comprises the following components in parts by mass: 0.01-0.45% of icodextrin, 0.06-0.8% of sodium hyaluronate, 4-4.9% of propylene glycol, 0.05-0.1% of chlorphenesin, 0.4-0.5% of phenoxyethanol, 0.1-0.5% of ethylhexyl glycerol, 0.3-0.5% of 1, 2-hexanediol, 93-95% of purified water or water for injection and 0.001-0.005% of flavoring agent.

The sodium hyaluronate is micromolecular sodium hyaluronate.

The corrective is a natural plant extraction aromatic.

In the application, the natural plant extracted aromatic is one or more of neroli essential oil, peppermint essential oil, lavender essential oil and rose essential oil.

The sodium hyaluronate dressing provided by the invention is prepared by adopting a conventional preparation method.

The technical scheme disclosed by the invention has the following beneficial effects:

(1) moisture preservation and repair: according to the invention, sodium hyaluronate and icodextrin are combined, so that the obtained adhesive dressing can obtain a good moisturizing and repairing effect in various seasons and regions, has the effects of removing oxygen free radicals on the surface of skin, accelerating skin metabolism, promoting skin regeneration of a wound part and relieving pain, and can also make normal skin tender, smooth and elastic.

(2) Nutrition lubrication: the dressing can form a layer of film on the surface of skin, so that the skin can generate good smooth feeling and moist feeling, and the dressing has a protective effect on the skin.

(3) No thickener is required: the dressing is in an essence state, does not need a thickening agent, reduces the addition, reduces the skin burden and reduces the production cost.

Drawings

FIG. 1 is an electron microscope image of the dressing film obtained in example 1;

FIG. 2 is an electron microscope image of the dressing obtained in example 2 after film formation;

FIG. 3 is an electron microscope image of the film formed by applying the dressing obtained in example 3.

Detailed Description

The present invention will be further described with reference to the following detailed description, but the scope of the present invention is not limited to the description.

The sodium hyaluronate adhesive dressing can be produced by adopting all applicable processes.

Example 1:

icodextrin 0.008%, sodium hyaluronate 0.08%, propylene glycol 3.6%, chlorphenesin 0.05%, phenoxyethanol 0.3%, ethylhexyl glycerin 0.5%, 1, 2-hexanediol 0.5%, purified water 94.96%, and orange flower essential oil 0.002%.

Example 2:

icodextrin 0.45%, sodium hyaluronate 0.1%, propylene glycol 4.5%, chlorphenesin 0.06%, phenoxyethanol 0.45%, ethylhexylglycerin 0.1%, 1, 2-hexanediol 0.4%, purified water or water for injection 93.937%, and orange flower essential oil 0.003%.

Example 3:

icodextrin 0.03%, sodium hyaluronate 0.6%, propylene glycol 4.2%, chlorphenesin 0.08%, phenoxyethanol 0.44%, ethylhexyl glycerin 0.3%, 1, 2-hexanediol 0.3%, purified water or water for injection 94.048%, and rose essential oil 0.002%.

(1) The film forming effect of the above examples was tested, and the obtained examples had good air permeability after film formation, and the data obtained by performing tensile tests were:

	example 1	Example 2	Example 3
				Tensile strength/MPa	2.64	2.73	3.1

As can be seen from FIGS. 1-3, the obtained patch has uniform pores after film formation, high porosity and good air permeability during application.

(2) The collagen dressing containing the icodextrin prepared by the common preparation method of the embodiment and the gauze (each piece of the dressing contains 10g of the composition in the embodiment) is applied to the face of 3 subjects who have undergone micro-needle beautifying, in the using process, the dressing is applied to half of each subject, the half of each subject is used as a control group, one piece is applied every first two days, one piece is applied every other day, seven days are taken as a treatment course, in the application process, the subject feels elegant and fresh in fragrance of the obtained dressing, the application process is comfortable, the good moisturizing and repairing effect is achieved, no adverse reaction is caused, after one treatment course is finished, the three subjects apply the dressing, the skin is plump and white on one side, no micro-needle holes are not silted, the other side is recovered relatively slowly, and the phenomena of needle holes and silted are remained.

The above examples describe specific embodiments of the present invention in detail, but the present invention is not limited to the above embodiments, and various changes can be made without departing from the gist of the present invention within the knowledge of those skilled in the art.

Claims

1. The utility model provides a dressing is pasted to sodium hyaluronate who contains icodextrin which characterized in that: the pasting dressing comprises the following components in parts by mass: 0.008-0.05% of icodextrin, 0.05-0.1% of sodium hyaluronate, 3-6% of propylene glycol, 0.02-0.1% of chlorphenesin, 0.3-0.5% of phenoxyethanol, 0.1-0.5% of ethylhexyl glycerol, 0.3-0.5% of 1, 2-hexanediol, 93-95% of purified water or water for injection and 0.001-0.005% of flavoring agent.

2. The sodium hyaluronate patch dressing containing icodextrin according to claim 1, wherein: the pasting dressing comprises the following components in parts by mass: 0.01-0.45% of icodextrin, 0.06-0.8% of sodium hyaluronate, 4-4.9% of propylene glycol, 0.05-0.1% of chlorphenesin, 0.4-0.5% of phenoxyethanol, 0.1-0.5% of ethylhexyl glycerol, 0.3-0.5% of 1, 2-hexanediol, 93-95% of purified water or water for injection and 0.001-0.005% of flavoring agent.

3. The icodextrin-containing sodium hyaluronate patch dressing according to claims 1 and 2, wherein: the sodium hyaluronate is small molecule sodium hyaluronate.

4. The icodextrin-containing sodium hyaluronate patch dressing according to claims 1 and 2, wherein: the flavoring agent is natural plant extract flavoring agent.

5. The sodium hyaluronate patch dressing containing icodextrin according to claim 4, wherein: the natural plant extracted aromatic is one or more of neroli essential oil, peppermint essential oil, lavender essential oil and rose essential oil.