CN106109296B - A kind of moisturizing essence lotion and preparation method thereof - Google Patents
A kind of moisturizing essence lotion and preparation method thereof Download PDFInfo
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- CN106109296B CN106109296B CN201610512382.5A CN201610512382A CN106109296B CN 106109296 B CN106109296 B CN 106109296B CN 201610512382 A CN201610512382 A CN 201610512382A CN 106109296 B CN106109296 B CN 106109296B
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- China
- Prior art keywords
- sodium hyaluronate
- skin
- sodium
- hyaluronic acid
- essence lotion
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- 230000008092 positive effect Effects 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000034272 protein filaments Human genes 0.000 description 1
- 108091005974 protein filaments Proteins 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The application belongs to cosmetic technical field, and in particular to a kind of moisturizing essence lotion and preparation method thereof.By weight percentage; contain Sodium Hyaluronate 0.00003% 25.5% in the essence lotion; acetylation Sodium Hyaluronate 0.00001% 20%; hydrolyze hyaluronic acid 0.00001% 20%; thickener 0.001% 1%; NMF 0.5% 40%, skin effect agent 0.1% 30%, surplus is deionized water.The essence lotion provided by the application, Skin Cell activity can be inherently adjusted, plays a part of whitening, crease-resistant, anti aging effect, particularly with inflammatory skin such as acne, acne etc., skin surface bacterial activity can be suppressed, reduced inflammation.
Description
Technical field
The invention belongs to cosmetic technical field, and in particular to a kind of moisturizing essence lotion and preparation method thereof.
Background technology
Influenceed because modern people's rhythm of life is fast, and by various environment, skin is often dried, intensely dark pool, is changed
Cosmetic is increasingly widely used as commodity.Due to essence lotion have nutrient composition content it is high, it is small to skin irritatin,
The features such as skin cytoactive can be adjusted, even more it is considered as the necessity of skin basic nursing by numerous women.
Hyaluronic acid, referred to as HA, be by D-Glucose aldehydic acid and 2-Acetamido-2-deoxy-D-glucose by β-(1-3) and β-
The acid mucopolysaccharide with high molecular weight and viscosity that (1-4) glycosidic bond is formed by connecting.In body, hyaluronic acid is one
The multi-functional matrix of kind, shows a variety of important physiological functions, such as regulatory protein matter, assists diffusion and the fortune of Water-Electrolyte
Turn, lubricating joint, adjust the permeability of vascular wall, promote wound healing etc..Particular, it is important that hyaluronic acid have it is special
Water retention, be the material that moisture retention is best in the nature having now been found that, 1 gram of hyaluronic acid can pin 500-1000 grams
Water.Hyaluronic acid obtains because it has unique physicochemical property and physiological function in terms of medical science, biology, material
Extensive use.
The derivative Sodium Hyaluronate of hyaluronic acid is as NMF its moistening effect than 2-pyrrolidone-5-carboxylic acid, sorbierite
More excellent than keratin, PVA as its film-strength of film forming agent and elasticity and glycerine is excellent, angle is compared in the smoothing effect to epidermis
Albumen, chondroitin sulfate etc. are excellent, are widely used to superior cosmetics production, are described as the raw material of the present age modish cosmetics.
Sodium Hyaluronate uses in cosmetics usually as NMF, saturating using macromolecule in existing many cosmetics
Raw material of the bright matter acid sodium as moisturizing, but polymer hyaluronic acid sodium has higher viscosity, and operation is made in Cosmetic Manufacture
Become difficult, being such as added in cosmetics makes stirring difficult, filtration difficulty, extends manufacture cycle, and polymer hyaluronic acid
Sodium simply forms one layer of ventilative film in skin surface, moistens skin smooth, is but not easy skin permeation and is absorbed by the skin.
Chinese patent application 201410272346.7《A kind of moisturizing essence lotion and preparation method thereof》Disclose a kind of moisturizing
Essence lotion, this essence lotion is mainly by deionized water, watermelon peel extract solution, rose pure dew, hazel extract, hyalomitome
Acid, collagen, polyglutamic acid, lotus extract solution and carbomer are made.Due to being rich in various active principles in essence lotion, reach
Well to face skin moisturizing whitening effect, while skin of face is not stimulated, can be long-term use of.But due in essence lotion
Active ingredient is mainly plant extracts, is easily become sour, therefore the shelf-life is short, expensive, is not easy to receive for masses.
Chinese patent application 201410257195.8《A kind of skin moisturizer containing hyaluronic acid》One kind is disclosed to contain
There is the skin moisturizer of hyaluronic acid.This skin moisturizer can quickly and effectively moisten drying to the good penetrability of skin
Skin, it is not sticky.But the main moisturizing ingredient in the NMF is the low molecular weight hyaluronic acid easily penetrated into inside skin, is caused
The moisture preserving time of above-mentioned NMF is short.
Chinese patent application 200810163779.3《The sodium hyaluronic acid raw-liquor of efficient moisture-retention》Disclose a kind of efficiently guarantor
Wet sodium hyaluronic acid raw-liquor, it is in 2,600,000 dalton above high molecular weight sodium hyaluronates and molecule by mean molecule quantity
Measure the nanoscale low molecular weight sodium hyaluronate proportioning composition below 10,000 dalton.This hyaluronic acid stoste is advantageous to skin
Absorption of the skin to nutriment, the crease-resistant health-care effect of beauty is played, there is stronger viscoelasticity and lubricity again, is applied to skin table
Face can form one layer of moisturizing ventilated membrane, keep skin moisturizing glossy.But the sodium hyaluronic acid raw-liquor purposes is more single, for skin
Inflammatory patients can not play a role in improving.
The content of the invention
In order to solve above mentioned problem existing for essence lotion in the prior art, the first purpose of the application, which is to provide one kind, to be had
Long-acting moistening effect, the moisturizing essence lotion that skin activity, long shelf-life can be improved from inside.
In order to realize foregoing invention purpose, the technical scheme of the application provides a kind of moisturizing essence lotion, by weight
Percentages, contain Sodium Hyaluronate 0.00003%-25.5%, acetylation Sodium Hyaluronate in the moisturizing essence lotion
0.00001%-20%, hyaluronic acid 0.00001%-20%, thickener 0.001%-1%, NMF 0.5%-40% are hydrolyzed,
Skin effect agent 0.1%-30%, surplus is deionized water.
Preferably, the Sodium Hyaluronate, acetylation Sodium Hyaluronate, the weight ratio of hydrolysis hyaluronic acid are (0.2-
10):(0.015-1):(0.015-1)。
More preferably (2-10):(0.015-0.05):(0.015-0.05), it is still more preferably (2-10):
(0.015-0.02):(0.015-0.02)；Such as：2:0.015:0.015；Or 10:0.015:0.015；Or 5:0.015:
0.015.The essence lotion being prepared in this proportion, production cost are relatively low.
The Sodium Hyaluronate, acetylation Sodium Hyaluronate, the weight ratio of hydrolysis hyaluronic acid can also be more preferably
(0.2-10):(0.1-1):(0.1-1), it is still more preferably (0.2-8):(0.5-1):(0.5-1)；For example, 0.2:0.5:
0.5；Or 8:1:1；Or 0.2:0.5:1；Or 8:1:0.5.The essence lotion being prepared in this proportion, moistening effect compared with
It is good.
Wherein, Sodium Hyaluronate can be divided into macromolecular Sodium Hyaluronate, middle numerator sodium hyaluronate according to molecular size range
With micromolecule hyaluronic acid sodium, wherein, macromolecular Sodium Hyaluronate refer to Sodium Hyaluronate molecular weight be more than 1.8 × 106Da；In
Numerator sodium hyaluronate refers to Sodium Hyaluronate molecular weight between 1 × 106-1.8×106Da；Micromolecule hyaluronic acid sodium refers to
Bright matter acid sodium molecule amount is less than 1 × 105Da；Herein described micromolecule hyaluronic acid sodium is preferably that molecular weight is less than 7000Da；
Sodium Hyaluronate in herein described moisturizing essence lotion can be its in large, medium and small numerator sodium hyaluronate
Middle a kind of or at least any two kinds of mixing,
Preferably, it is saturating to include macromolecular Sodium Hyaluronate, middle numerator sodium hyaluronate and small molecule for the Sodium Hyaluronate
Bright matter acid sodium, and the weight ratio of large, medium and small numerator sodium hyaluronate is (1-500):(2.5-500)：(1-100)；It is further excellent
Elect as (50-500)：(50-500)：(1-10)；Still more preferably it is (100-500)：(100-500)：(1-5)；Such as 500:
500:1；Or 500:500:5；Or 500:200:2.The essence lotion being prepared in this proportion, production cost are relatively low.
Aforementioned proportion can also be more preferably：(1-100)：(2.5-100)：(50-100)；More a step is preferably：(1-
50)：(2.5-50)：(50-100)；Such as：1:2.5:50；Or 1:50:100；Or 50:2.5:100.Made in this proportion
Standby obtained essence lotion, moistening effect are preferable.
As a kind of embodiment, by weight percentage, macromolecular Sodium Hyaluronate is contained in the moisturizing essence lotion
0.0001%-0.5%, middle numerator sodium hyaluronate 0.01%-5%, micromolecule hyaluronic acid sodium 0.0001%-20%, acetyl
Change Sodium Hyaluronate 0.0001%-20%, hydrolyze Sodium Hyaluronate 0.0001%-20%, thickener 0.1%-1%, NMF
5%-40%, skin effect agent 1%-30%, surplus is deionized water；
The Sodium Hyaluronate, acetylation Sodium Hyaluronate, the weight ratio of hydrolysis hyaluronic acid are (0.2-10):1:1.
As another embodiment, by weight percentage, macromolecular hyaluronic acid is contained in the moisturizing essence lotion
Sodium 0.0001%-20%, middle numerator sodium hyaluronate 0.01%-5%, micromolecule hyaluronic acid sodium 0.0001%-0.2%, second
Acylated Sodium Hyaluronate 0.0001%-0.2%, hydrolyzes Sodium Hyaluronate 0.0001%-0.2%, thickener 0.1%-1%, protects
Humectant 5%-40%, skin effect agent 1%-30%, surplus is deionized water；
The Sodium Hyaluronate, acetylation Sodium Hyaluronate, the weight ratio of hydrolysis hyaluronic acid are (0.2-10):0.015:
0.015。
Preferably, the thickener is selected from carbomer or its sodium salt, C10-30 alkylol acrylamide acid esters cross-linked polymer, xanthan
One or more in glue, Arabic gum, mosanom, cellulose and cellulose gum.
Wherein, the cellulose gum is hydroxyethyl cellulose or sodium carboxymethylcellulose, it is preferable that herein described thickening
Agent is the combination of mosanom, cellulose and cellulose gum；It is further preferred that the weight of mosanom, cellulose and cellulose gum
Than for 45:30:25.
Preferably, the one kind or more of the NMF in glycerine, polyglycereol, glycerin polyether, propane diols and erythrite
Kind.
It is further preferred that the polyglycereol is polyglycereol -6 or Natrulon H-10；
The glycerin polyether is glycerin polyether -26；
The propane diols is 1,3- propane diols.
Preferably, skin effect agent is selected from beta glucan, glycine betaine, trehalose, biological polyoses glue, purslane extraction
One or more in thing, Narcissus Tazetta L. Var extract, glycosphingolipids and rice tunning filtrate.
It is further preferred that the beta glucan is avenabeta glucosan；
The biological polyoses glue is one kind in biological carbohydrate gum -1, biological carbohydrate gum -2, biological carbohydrate gum -3 and biological carbohydrate gum -4
Or it is a variety of, it is still more preferably biological carbohydrate gum -1.
Wherein, herein described skin effect agent, the new old generation of cell can be improved by stimulating skin key cells
Thank speed and defending performance or suppress the activity of key enzyme, and then play and improve neoblast ratio, improve skin elasticity, eliminate
Wrinkle or the function of promoting impaired skin to recover.
Wherein, the beta glucan in skin effect agent described herein can change the activity of macrophage in skin,
Macrophage produces EGF, and then promotes the generation of collagen and elastin laminin, so as to improve cuticula again
Raw speed, promotes phagocyte to remove external antigen, inflammatory products, promotes inflammation to recover.
Glycine betaine is a kind of high natural amino acid NMF of the fast activity of absorption.Large quantity of moisture can be provided for skin.For
The formation of protein, DNA reparation, the activity of enzyme play an important roll.
Trehalose is a kind of natural polysaccharide, and its molecular weight is small, is easy to be absorbed by the skin, unique into it is played into the cell
Water substitutes the function of stress factor effect and protection cell membrane, resist drying, the freezing tolerance of cell is improved, so as to improve skin
Adapt to the ability of environment.With excellent hygroscopicity, biological preservation and intelligence can be had concurrently with hyaluronic acid, glycine betaine synergy
Can moisture-keeping function.Due to the freezing point of aqueous phase can be reduced, with other components compatibilities using when can also play the work of " stabilizer "
With.
Glycosphingolipids, CAS No:308067-30-3, extracted from rice bran shell, by making ceramide glycosylation
It becomes water-soluble, and it can increase the adhesive capacity of skin keratin, and help supplements the ceramide that skin lacks, and adjusts skin water
Shunting is lost, and repairs the quality of dry cuticula and skin sparing barrier, recovers the natural cover for defense of skin.Apply and use on skin
Afterwards, increase the water holding capacity of skin, skin become soft, smooth, recovered elasticity.
Biological polyoses glue -1 is to be obtained by techniques such as fermentations from natural plants, can form strength protection in skin surface and make
3D films, so as to play a part of moisturizing, improve skin sense；Inflammation and mistake can also be adjusted with horn cell acceptor interaction
It is quick, promote the differentiation of horn cell.
Purslane extract is to extract obtained water-soluble substances from purslane.It can improve histiocytic activity,
And anti-inflammatory and anti-irritant.Purslane extract used herein is added in the form of Purslane extract when in use,
Specifically, the percentage by weight of each component is in Purslane extract：Purslane extract 5%, polylysine 0.05%, benzene first
Sour sodium 0.03%, ethylenediamine tetraacetic ethyl disodium 0.02%, 1,2- hexylene glycol 0.5%, water 94.4%.
Narcissus Tazetta L. Var extract is the water-soluble substances for extracting to obtain from rest period Narcissus Tazetta L. Var.The extract can subtract
The differentiation of slow horn cell, melanocyte, hair follicle cell, so as to crease-resistant, whitening, the effect of hair growth inhibition.This
Narcissus Tazetta L. Var extract used in application is added in the form of Narcissus Tazetta L. Var extract solution when in use, specifically, Narcissus Tazetta L. Var extraction
The percentage by weight of each component is in liquid：Narcissus Tazetta L. Var extract 0.7-1.1%, water 98.51-99.11%, Phenoxyethanol
0.40-0.60%, potassium sorbate 0.22-0.38%, Chlorphenesin 0.12-0.28%.
Rice tunning filtrate is the water-soluble substances being filtrated to get after rice ferments, also known as female's vinasse.It can be with
Promote the NMF Protein filament polymeric protein in epidermal cell, natural moisture preserving is decomposed to form under bioactivity enzyme effect
(NMF is the small molecule complexes that a kind of skin itself has and had water absorption character to factor NMF, effectively can absorb and pin
Moisture, coordinate Guardwall structures, strengthen water lock barrier).Contain percetage by weight in rice tunning filtrate used herein
For 30% butanediol, percetage by weight is 70% rice tunning filtrate.
Preferably, it is herein described also containing the anti-corrosive aids that percetage by weight is 0.5-8% in the moisturizing essence lotion
Anti-corrosive aids, different from traditional preservative, i.e., not at 2015 editions《Cosmetics health specification》The row of preservative, but
Material with preservative efficacy.They are small to skin irritation, and can play synergistic function with other auxiliary agents.Specifically
Ground, it is smooth pungent that the anti-corrosive aids are selected from decoyl hydroximic acid, C3-6 aliphatic dihydric alcohol, parahydroxyacet-ophenone, pungent glycol and sorb
One or more in acid esters.
Preferably, the aliphatic dihydric alcohol of the C3-6 is one in 1,2- hexylene glycols, 1,2- pentanediols and 1,3-PD
Kind is a variety of.
It is further preferred that the anti-corrosive aids are the combination of decoyl hydroximic acid, 1,2- hexylene glycols and 1,3-PD；This
Under combining form, 1,3-PD and 1,2- hexylene glycol can make NMF in itself, can be cooperateed with other NMFs, skin effect agent
Moisturizing, whitening；Solubilized hydrotropy can also be played a part of, reduce the dosage of solubilizer.
In addition to above-mentioned thickener, NMF, the agent of skin effect, anti-corrosive aids, herein described moisturizing essence lotion can basis
Preparation technology or the needs of consumer, it can also add other auxiliary agents, such as solubilizer, essence.
Preferably, the solubilizer is the one or more in rilanit special used for cosmetic, Tweens and butylol polyether；
Essence is that cosmetics often use essence, the preferably plant essence in natural essence, specially bouquet type composition, as rose is savory
Essence.
Preferably, the solubilizer is the combination of rilanit special and butylol polyether, specifically,
Rilanit special is PEG-40, -60 and -80 rilanit specials in one or more；Butylol polyether gathers for butanol
Ether -26.
It is further preferred that solubilizer is the combination of Cremophor RH40 and butylol polyether -26, and the weight of the two
Than for (53-65)：(34-46), when in use, Cremophor RH40, butylol polyether -26 and deionized water using weight ratio as
(53-65)：(34-46)：The form of (9-11) carries out well mixed rear stand-by.
As another embodiment, by weight percentage, contain Sodium Hyaluronate in the moisturizing essence lotion
0.65%, acetylation Sodium Hyaluronate 0.5%, hydrolyze hyaluronic acid 0.5%, thickener 0.16%, NMF 27%, skin work(
Agent 21% is imitated, anti-corrosive aids 1%, solubilizer 0.2%, essence 0.001%, surplus is deionized water.
Preferably, by weight percentage, macromolecular Sodium Hyaluronate 0.1% is contained in the moisturizing essence lotion, in point
Sub- Sodium Hyaluronate 0.05%, micromolecule hyaluronic acid sodium 0.5%, acetylation Sodium Hyaluronate 0.5%, hydrolyze hyaluronic acid
0.5%, C10-30 alkylol acrylamide acid esters cross-linked polymer 0.06%, carbomer sodium 0.1%, 1,3-PD 8%, glycerine 8%,
Erythrite 8%, polyglycereol -6 1%, glycerin polyether -26 2%, beta glucan 5%, glycine betaine 4%, trehalose 2%, biology sugar
Glue -1 2%, purslane extract 2%, Narcissus Tazetta L. Var extract 2%, glycosphingolipids 2%, rice tunning filtrate 2%, 1,
2- hexylene glycols 0.5%, decoyl hydroximic acid 0.5%, solubilizer 0.2%, essence 0.001%, surplus are deionized water.
Another technical scheme of the application provides a kind of preparation method of above-mentioned moisturizing essence lotion, and it includes following step
Suddenly：
1) each material is first weighed by weight, then add thickener in deionized water, stir lower addition hyaluronic acid
Sodium, hyaluronan sodium and hydrolysis hyaluronic acid, stirring are warming up to 80~90 DEG C, are incubated 10-30 minutes；
2) NMF is added, skin effect agent is added when being cooled to 40~55 DEG C；
3) when being cooled to 30~40 DEG C after product control Preliminary detection is qualified 200 mesh filtering and dischargings.
Preferably, anti-corrosive aids are contained in the moisturizing essence lotion, its preparation method comprises the following steps：
1) each material is first weighed by weight, anti-corrosive aids are then heated to 70~80 DEG C, stirring to dissolving obtains completely
Solution 1, it is stand-by；
2) thickener is added in deionized water, it is saturating stirs lower addition Sodium Hyaluronate, hyaluronan sodium and hydrolysis
Bright matter acid, stirring are warming up to 80~90 DEG C, are incubated 10-30 minutes；
3) NMF is added, step 1) resulting solution 1 is added when being cooled to 70~80 DEG C；
4) skin effect agent is added when being cooled to 40~55 DEG C；
5) when being cooled to 30~40 DEG C after product control Preliminary detection is qualified 200 mesh filtering and dischargings.
Moisturizing essence lotion provided herein, due to the moisturizing ingredient containing different molecular weight, skin difference can be met
The moisturizing of degree needs, and such as micromolecule hyaluronic acid sodium, hydrolysis Sodium Hyaluronate, which can be penetrated into inside skin, plays deep layer benefit
The effect of water, while middle molecule, macromolecular Sodium Hyaluronate form tridimensional network in skin surface, play long-acting moisturizing
Effect.Such as beta glucan that contains in essence lotion, purslane extract skin effect agent, can activate to a certain degree it is specific
Cell, improve anti-inflammatory, the anti-irritant of skin.General user's long-term use can inherently adjust Skin Cell activity, play
Whitening, crease-resistant, anti aging effect effect, particularly with inflammatory skin such as acne, acne etc., it is thin skin surface can be suppressed
Bacterium activity, reduces inflammation.
Compared with prior art, the moisturizing essence lotion that the application provides has the advantages that：
1) stability is good, is applicable to different temperatures environment；
2) there is preferable moistening effect in a short time, the moisturizing essence lotion such as provided by embodiment 3-8 is within 4 weeks i.e.
Show obvious moistening effect；And show preferable property in terms of elasticity improves, melanin reduces, pore shrinks three
Energy.
3) there is preferable improvement, the moisturizing essence lotion such as provided by embodiment 3, scytitis to inflammatory skin
Patient's scytitis after using 4 weeks can improve nearly 10%, improve 15% after 9 weeks.
Embodiment
The present invention is further elaborated with reference to embodiment.These embodiments are only in order at purpose of explanation,
And do not limit the scope of the invention and essence.
Embodiment 1
A kind of moisturizing essence lotion, by weight percentage, it contains macromolecular Sodium Hyaluronate 1.2%, and middle molecule is transparent
Matter acid sodium 5%, micromolecule hyaluronic acid sodium 0.01%, acetylation Sodium Hyaluronate 0.01%, Sodium Hyaluronate 0.01% is hydrolyzed,
Thickener 0.1%, NMF 35%, skin effect agent 10%, surplus is deionized water.
The method for preparing the moisturizing essence lotion, step are specific as follows：
1) each material is first weighed by weight, then add thickener in deionized water, stir lower addition hyaluronic acid
Sodium, hyaluronan sodium and hydrolysis hyaluronic acid, stirring are warming up to 88~90 DEG C, are incubated 15-20 minutes；
2) NMF is added, skin effect agent is added when being cooled to 50~55 DEG C；
3) when being cooled to 30~35 DEG C after product control Preliminary detection is qualified 200 mesh filtering and dischargings.
Embodiment 2
A kind of moisturizing essence lotion, by weight percentage, it contains macromolecular Sodium Hyaluronate 0.001%, and middle molecule is saturating
Bright matter acid sodium 0.1%, micromolecule hyaluronic acid sodium 0.5%, acetylation Sodium Hyaluronate 0.01%, hydrolyze Sodium Hyaluronate
0.01%, thickener 0.1%, NMF 10%, skin effect agent 10%, surplus is deionized water.
The method of the moisturizing essence lotion is prepared with embodiment 1.
Embodiment 3
A kind of moisturizing essence lotion, by weight percentage, macromolecular Sodium Hyaluronate is contained in the moisturizing essence lotion
0.1%, middle numerator sodium hyaluronate 0.05%, micromolecule hyaluronic acid sodium 0.5%, acetylation Sodium Hyaluronate 0.5%, hydrolysis
Hyaluronic acid 0.5%, C10-30 alkylol acrylamide acid esters cross-linked polymer 0.06%, carbomer sodium 0.1%, 1,3-PD 8%,
Glycerine 8%, erythrite 8%, polyglycereol -6 1%, glycerin polyether -26 2%, beta glucan 5%, glycine betaine 4%, trehalose
2%, biological carbohydrate gum -1 2%, 1,2- hexylene glycol 0.5%, decoyl hydroximic acid 0.5%, purslane extract 2%, Narcissus Tazetta L. Var carries
Thing 2% is taken, glycosphingolipids 2%, rice tunning filtrate 2%, solubilizer 0.2%, essence 0.001%, surplus is deionization
Water.
Wherein, it is 53 by weight by Cremophor RH40, butylol polyether -26 and water that the solubilizer, which is,:37:10
It is mixed to prepare.
Prepare comprising the following steps that for the moisturizing essence lotion：
1) each material is first weighed by weight, be then well mixed 1,2- hexylene glycols, 1,3-PD, decoyl hydroximic acid
After be heated to 80 DEG C, stirring, to dissolving completely solution 1, it is stand-by；
2) C10-30 alkylol acrylamide acid esters cross-linked polymer, carbomer sodium are added in deionized water, stirs lower add thoroughly
Bright matter acid sodium, hyaluronan sodium and hydrolysis hyaluronic acid, stirring are warming up to 90 DEG C, are incubated 10 minutes；
3) glycerine, polyglycereol -6, glycerin polyether -26 are added, step 1) resulting solution 1 is added when being cooled to 80 DEG C；
4) beta glucan, glycine betaine, trehalose, biological carbohydrate gum -1, erythrite, purslane is first added when being cooled to 50 DEG C to carry
Take thing, Narcissus Tazetta L. Var extract, glycosphingolipids and rice tunning filtrate；Solubilizer and essence are added after stirring；
5) when being cooled to 32 DEG C after product control Preliminary detection is qualified 200 mesh filtering and dischargings.
Wherein, gained essence lotion outward appearance is water white transparency low viscosity liquid, savory；PH is 6.50；Viscosity is 1500mPas.
Embodiment 4
A kind of moisturizing essence lotion, by weight percentage, it includes macromolecular Sodium Hyaluronate 0.00001%, middle molecule
Sodium Hyaluronate 0.0001%, micromolecule hyaluronic acid sodium 0.001%, acetylation Sodium Hyaluronate 0.00555%, hydrolysis are transparent
Matter acid 0.00555%, Arabic gum 0.1%, carbomer 0.1%, Natrulon H-10 12%, glycerine 8%, the filter of rice tunning
Liquid 15%, phytosphingosine 15%, surplus are deionized water.
Prepare comprising the following steps that for the moisturizing essence lotion：
1) each material is first weighed by weight, then add Arabic gum, carbomer in deionized water, stir lower add
Sodium Hyaluronate, hyaluronan sodium and hydrolysis hyaluronic acid, stirring are warming up to 80 DEG C, are incubated 15 minutes；
2) Natrulon H-10, glycerine are added, rice tunning filtrate, phytosphingosine are added when being cooled to 40 DEG C；
3) when being cooled to 35 DEG C after product control Preliminary detection is qualified 200 mesh filtering and dischargings.
Wherein, gained essence lotion outward appearance is water white transparency low viscosity liquid；PH is 7.2；Viscosity is 1200mPas.
Embodiment 5
A kind of moisturizing essence lotion, by weight percentage, it includes macromolecular Sodium Hyaluronate 1%, small molecule hyalomitome
Sour sodium 20%, acetylation Sodium Hyaluronate 2.1%, hydrolyze hyaluronic acid 2.1%, hydroxyethyl cellulose 0.08%, mosanom
0.05%, Natrulon H-10 7%, 1,3-PD 5%, glycine betaine 10%, trehalose 3%, glycosphingolipids 15%, surplus is to go
Ionized water.
Prepare comprising the following steps that for the moisturizing essence lotion：
1) each material is first weighed by weight, then add hydroxyethyl cellulose, mosanom in deionized water, under stirring
Add Sodium Hyaluronate, hyaluronan sodium and hydrolysis hyaluronic acid, stirring and be warming up to 83 DEG C, be incubated 15 minutes；
2) Natrulon H-10,1,3-PD are added, glycine betaine, trehalose, glycosphingolipids are added when being cooled to 45 DEG C；
3) when being cooled to 30 DEG C after product control Preliminary detection is qualified 200 mesh filtering and dischargings.
Wherein, gained essence lotion outward appearance is water white transparency low viscosity liquid；PH is 6.8；Viscosity is 1000mPas.
Embodiment 6
A kind of moisturizing essence lotion, by weight percentage, it includes macromolecular Sodium Hyaluronate 0.5%, and small molecule is transparent
Matter acid sodium 5%, acetylation Sodium Hyaluronate 5%, hydrolysis hyaluronic acid 5%, cellulose 0.001%, Arabic gum 0.002%,
1,3-PD 10%, polyglycereol -6 10%, rice tunning filtrate 15%, surplus is deionized water.
Prepare comprising the following steps that for the moisturizing essence lotion：
1) each material is first weighed by weight, then add cellulose, Arabic gum in deionized water, stir lower add
Sodium Hyaluronate, hyaluronan sodium and hydrolysis hyaluronic acid, stirring are warming up to 80 DEG C, are incubated 25 minutes；
2) polyglycereol -6,1,3-PD are added, rice tunning filtrate is added when being cooled to 45 DEG C；
3) when being cooled to 30 DEG C after product control Preliminary detection is qualified 200 mesh filtering and dischargings.
Wherein, gained essence lotion outward appearance is water white transparency low viscosity liquid；PH is 7.5；Viscosity is 1300mPas.
Embodiment 7
A kind of moisturizing essence lotion, by weight percentage, it includes macromolecular Sodium Hyaluronate 1%, acetylation hyalomitome
Sour sodium 0.05%, hydrolysis hyaluronic acid 0.05%, mosanom 0.45%, cellulose 0.3%, cellulose gum 0.25%, polyglycereol-
10 0.5%, 1,2-PD 0.5%, glycerin polyether -26 0.5%, erythrite 0.5%, purslane extract 20%, 1,3-
Propane diols 1%, parahydroxyacet-ophenone 0.05%, essence 0.0008%, surplus are deionized water.
Prepare comprising the following steps that for the moisturizing essence lotion：
1) each material is first weighed by weight, be heated to after being then well mixed 1,3-PD, parahydroxyacet-ophenone
80 DEG C, stirring, mixture is obtained completely to dissolving, it is stand-by；
2) mosanom, cellulose, cellulose gum are added in deionized water, it is saturating stirs lower addition Sodium Hyaluronate, acetyl
Bright matter acid sodium and hydrolysis hyaluronic acid, stirring are warming up to 80 DEG C, are incubated 30 minutes；
3) Natrulon H-10,1,2-PD are added, purslane extract is added when being cooled to 45 DEG C；When being cooled to 30 DEG C
The 200 mesh filtering and dischargings after product control Preliminary detection is qualified.
Wherein, gained essence lotion outward appearance is water white transparency low viscosity liquid；PH is 7.2；Viscosity is 1100mPas.
Embodiment 8
A kind of moisturizing essence lotion, by weight percentage, it includes micromolecule hyaluronic acid sodium 10%, acetylation hyalomitome
Sour sodium 0.0001%, hydrolysis hyaluronic acid 0.0001%, mosanom 0.45%, cellulose 0.3%, cellulose gum 0.25%, 1,
Ammediol 8%, glycerine 8%, erythrite 8%, polyglycereol -6 1%, glycerin polyether -26 2%, beta glucan 5%, glycine betaine
4%, trehalose 2%, biological carbohydrate gum -4 2%,
1,2- hexylene glycol 0.5%, decoyl hydroximic acid 0.5%, Tween-20 0.5%, butylol polyether -26 0.5%, essence
0.0001%, surplus is deionized water.
Prepare comprising the following steps that for the moisturizing essence lotion：
1) each material is first weighed by weight, 80 are heated to after being then well mixed 1,2- hexylene glycols, decoyl hydroximic acid
DEG C, stirring, mixture is obtained completely to dissolving, it is stand-by；
2) mosanom, cellulose, cellulose gum are added in deionized water, it is saturating stirs lower addition Sodium Hyaluronate, acetyl
Bright matter acid sodium and hydrolysis hyaluronic acid, stirring are warming up to 80 DEG C, are incubated 30 minutes；
3) 1,3-PD, glycerine, erythrite, polyglycereol -6, glycerin polyether -26 are added, life is added when being cooled to 48 DEG C
Thing carbohydrate gum -4, glycine betaine, trehalose；Tween-20, butylol polyether -26 and essence are added after stirring；
4) when being cooled to 30 DEG C after product control Preliminary detection is qualified 200 mesh filtering and dischargings.
Wherein, gained essence lotion outward appearance is water white transparency low viscosity liquid；PH is 6.9；Viscosity is 1500mPas.
Embodiment 9
Stability test
High temperature, low-temperature stability experiment
The stability of moisturizing essence lotion made from embodiment 3-8 is measured, specific assay method is as follows：
(1) placed 30-50 days in 40 DEG C of -50 DEG C of electro-heating standing-temperature cultivators, recover room temperature after observe, (2) 24 hours it
It is interior, between 0 DEG C -50 DEG C back and forth frequently change, so repeatedly operate 15-30 days, recover room temperature after observe, (3) at -5 DEG C and
Circulation storage 3 times, deposit 24h every time respectively at 40 DEG C, i.e., after -5 DEG C are deposited 24h, deposit 24h at room temperature, place into 40
24h is deposited in DEG C insulating box, circulates 3 times successively, observes its stability；(4) deposited 1 week at -5 DEG C, observe its stability.
Observation item：Liquid-transparent, precipitation, microorganism growth, smell change；Wherein, total plate count and pathogenic bacteria are surveyed
Fixed experiment performs with reference to hygienic standards for cosmetics GB7916.87 method.
Measurement result table 1 specific as follows：
The stability of moisturizing essence lotion made from the embodiment 3-8 of table 1
Embodiment 10
Effect measuring
1st, moistening effect determines
With product made from embodiment 3-8 and the saturating white essence lotion of children of the Sinoway rhodiola root jade-like stone bought from market
(140mL) (contrast product) is test products, selects the female volunteers 140 of 25-60 year at random and is divided into 7 groups, every group 20
People.Respectively after 4 weeks and 9 weeks on probation measure user skin improvement situation, test condition be fixed on relative humidity 40~
60%, room temperature is to be carried out at 25 DEG C.Skin improves situation and is shown in Table 1.
The trier's cheek area skin of table 2 improves situation
The moisturizing essence lotion provided it can be seen from the data of table 2 by the application has improvement, embodiment to skin
(4 weeks) show obvious effect to the moisturizing essence lotion that 3-8 is provided in a short time.Wherein, embodiment 3,5 positive effects,
Preferable performance is shown in terms of elasticity improves, melanin reduces, pore shrinks three.
2nd, the improvement of inflammatory skin is determined
With product made from embodiment 3-8 and the saturating white essence lotion of children of the Sinoway rhodiola root jade-like stone bought from market
(150mL) (contrast product) is test products, selects the female skin inflammation volunteer 140 of 25-60 year at random and is divided into 7
Group, every group of 20 people.Determining the skin of user after on probation 4 weeks and 9 weeks respectively improves situation, and test condition is fixed on relatively wet
Degree 40~60%, room temperature are to be carried out at 25 DEG C.Skin improves situation and is shown in Table 3.Wherein, patient skin inflammation mitigates or fully recovered, acne
The elimination of print is believed that inflammation makes moderate progress.Inflammation improvement rate=inflammation improves number/number on probation.
Improvement of the Evaluation product of table 3 to inflammatory skin
Also the specific certain regulation of skin is made by moisturizing essence lotion provided herein it can be seen from the data of table 3
With long-term use can improve scytitis, and the patient that there are acne, acne etc. in the face that is particularly suitable for use in uses.
Only illustratively, the scope of the present invention is not limited thereto above-mentioned example.To those skilled in the art
For modify be it will be apparent that the present invention only limited by scope.
Claims (1)
1. a kind of moisturizing essence lotion, it contains macromolecular Sodium Hyaluronate 0.1%, middle numerator sodium hyaluronate 0.05%, small molecule
Sodium Hyaluronate 0.5%, acetylation Sodium Hyaluronate 0.5% hydrolyze hyaluronic acid 0.5%, and the crosslinking of C10-30 alkylol acrylamides acid esters is poly-
Compound 0.06%, carbomer sodium 0.1%, 1,3-PD 8%, glycerine 8%, erythrite 8%, polyglycereol -6 1%, glycerin polyether -26
2%, beta glucan 5%, glycine betaine 4%, trehalose 2%, biological carbohydrate gum -1 2%, purslane extract 2%, Narcissus Tazetta L. Var extract
2%, glycosphingolipids 2%, rice tunning filtrate 2%, 1,2- hexylene glycol 0.5%, decoyl hydroximic acid 0.5%, solubilizer 0.2%, perfume
Essence 0.001%, surplus is deionized water；
Wherein, macromolecular Sodium Hyaluronate refers to that Sodium Hyaluronate molecular weight is more than 1.8 × 106Da；Middle numerator sodium hyaluronate is
Refer to Sodium Hyaluronate molecular weight between 1 × 106-1.8×106Da；Micromolecule hyaluronic acid sodium refers to that Sodium Hyaluronate molecular weight is small
In 1 × 105Da。
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