CN110652470A - Moisturizing repair water and preparation method thereof - Google Patents
Moisturizing repair water and preparation method thereof Download PDFInfo
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 49
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 35
- 230000008439 repair process Effects 0.000 title abstract description 13
- 238000002360 preparation method Methods 0.000 title abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 36
- 238000003756 stirring Methods 0.000 claims abstract description 21
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 15
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 15
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 15
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 13
- 239000000787 lecithin Substances 0.000 claims abstract description 13
- 235000010445 lecithin Nutrition 0.000 claims abstract description 13
- 229940067606 lecithin Drugs 0.000 claims abstract description 13
- 102000016359 Fibronectins Human genes 0.000 claims abstract description 12
- 108010067306 Fibronectins Proteins 0.000 claims abstract description 12
- 235000010489 acacia gum Nutrition 0.000 claims abstract description 12
- 150000002339 glycosphingolipids Chemical class 0.000 claims abstract description 12
- 239000000230 xanthan gum Substances 0.000 claims abstract description 12
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 12
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 12
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 12
- 238000001816 cooling Methods 0.000 claims abstract description 11
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 10
- 229920000084 Gum arabic Polymers 0.000 claims abstract description 10
- 241000978776 Senegalia senegal Species 0.000 claims abstract description 10
- 239000000205 acacia gum Substances 0.000 claims abstract description 10
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000004359 castor oil Substances 0.000 claims abstract description 10
- 235000019438 castor oil Nutrition 0.000 claims abstract description 10
- 239000008367 deionised water Substances 0.000 claims abstract description 10
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 10
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 10
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 10
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000007599 discharging Methods 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 43
- 239000000047 product Substances 0.000 claims description 14
- 239000011265 semifinished product Substances 0.000 claims description 10
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 9
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 9
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 7
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 2
- 230000003750 conditioning effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- 230000005808 skin problem Effects 0.000 abstract description 8
- 239000006210 lotion Substances 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 238000004321 preservation Methods 0.000 abstract 2
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000004888 barrier function Effects 0.000 abstract 1
- 238000007689 inspection Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 27
- 239000000686 essence Substances 0.000 description 14
- 230000008591 skin barrier function Effects 0.000 description 12
- 238000012360 testing method Methods 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 206010013786 Dry skin Diseases 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000490 cosmetic additive Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000037067 skin hydration Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- Biophysics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention provides moisturizing repair water and a preparation method thereof, belongs to the technical field of skin care cosmetics, and comprises a phase A, a phase B and a phase C, wherein the phase A comprises deionized water: 77.0-93.0 parts of EDTA disodium: 0.01-0.03 part, butanediol: 1.0-4.0 parts of glycerol: 1.0-4.0 parts of pentanediol: 1.0-6.0 parts of xanthan gum: 0.01-0.3 parts and gum arabic: 0.01-0.3 part; phase B includes glycosphingolipids: 1.0-3.0 parts of lecithin-coated sodium hyaluronate: 0.5-2.0 parts and fibronectin: 0.1-2.0 parts; phase C comprises 1, 2-hexanediol: 0.5-2.0 parts of PEG-40 hydrogenated castor oil: 0.1-0.3 part and daily essence: 0.01-0.03 part; and the finished product is prepared by the steps of vacuum stirring, mixing and dissolving, cooling, heat preservation, inspection, discharging, sterile preservation, filling and the like for multiple times. The moisturizing lotion has remarkable barrier and effect of moisturizing, relieving and repairing skin, and can synchronously solve various skin problems of the face; the activity of each component is protected by a proper preparation method, so that the raw materials can fully play a synergistic function.
Description
Technical Field
The invention relates to the technical field of skin care cosmetics, in particular to repair water and a preparation method thereof.
Background
With the improvement of living standard, people pay more and more attention to maintenance and skin care products are more and more in variety.
However, the more skin care products are used, the better the skin care effect is, the more skin care products are applied, which is a burden for the skin, especially different efficacies, and products of different brands are mixed, which is especially easy to cause skin problems, such as skin sensitivity, red swelling, pruritus and the like, and the skin quality is also worse and worse; in addition, the urban living pressure is getting bigger and bigger, and the ecological environment is worsened, so that the skin problems of people are more and more, not single skin problems, but various skin problems coexist and influence each other. The effect of repairing only a single problem is limited, but a plurality of skin care products cannot be used simultaneously, so that the burden of the skin is increased.
The existing toner products on the market are mainly classified into moisturizing, soothing, whitening, anti-wrinkle and other types, are basically products with single efficacy, are difficult to achieve the synergistic effect, and can not solve various problems of facial skin of people, such as: the patent numbers are: CN201110329180, entitled "skin rejuvenation lotion"; the patent number is CN201811280698, and the name is 'an anti-allergy repair water and a preparation method thereof'; and products with the patent number of CN201811602765, namely a whitening cosmetic additive, a whitening essence stock solution and a preparation method thereof.
Therefore, it is highly desirable to develop a toner which can synergistically and simultaneously solve various skin problems of the face, thereby avoiding the skin burden caused by using various skin care products.
Disclosure of Invention
Aiming at the defects and shortcomings in the background technology, the moisturizing and repairing water provided by the invention can synchronously solve various skin problems of the face, has obvious effects of moisturizing, relieving and repairing skin barriers, can solve various skin problems by one bottle of the moisturizing and repairing water, and saves the time for caring the skin.
The invention also aims to provide a preparation method of the moisturizing repair water, which can effectively protect the activity of each component, so that the raw materials can fully play the function of synergy, and the maximization of moisturizing, relieving and repairing effects is achieved.
In order to realize the purpose, the invention adopts the following technical scheme to realize the purpose:
the moisturizing and repairing water comprises an A phase, a B phase and a C phase, wherein the A phase comprises the following components in parts by weight:
deionized water: 77.0-93.0 parts;
disodium EDTA: 0.01-0.03 part;
butanediol: 1.0-4.0 parts;
glycerol: 1.0-4.0 parts;
and (3) pentanediol: 1.0-6.0 parts;
xanthan gum: 0.01-0.3 part;
gum arabic: 0.01-0.3 part;
the phase B comprises the following components in parts by weight:
glycosphingolipids: 1.0-3.0 parts;
lecithin-coated sodium hyaluronate: 0.5-2.0 parts;
fibronectin: 0.1-2.0 parts;
the phase C comprises the following components in parts by weight:
1, 2-hexanediol: 0.5-2.0 parts;
PEG-40 hydrogenated castor oil: 0.1-0.3 part;
essence for daily use: 0.01 to 0.03 portion.
Further measures taken are: the phase A comprises the following components in parts by weight:
deionized water: 86.0 to 93.0 portions;
disodium EDTA: 0.01-0.02 portion;
butanediol: 1.0-2.0 parts;
glycerol: 2.0-3.0 parts;
and (3) pentanediol: 1.0-3.0 parts;
xanthan gum: 0.1-0.3 part;
gum arabic: 0.1-0.3 part;
the phase B comprises the following components in parts by weight:
glycosphingolipids: 1.0-2.0 parts;
lecithin-coated sodium hyaluronate: 0.5-1.0 part;
fibronectin: 0.5-1.0 part;
the phase C comprises the following components in parts by weight:
1, 2-hexanediol: 1.0-2.0 parts;
PEG-40 hydrogenated castor oil: 0.1-0.2 parts;
essence for daily use: 0.01 to 0.02 portion.
Further measures taken are: the phase A comprises the following components in parts by weight:
disodium EDTA: 0.01 part;
butanediol: 1.0 part;
glycerol: 2.0 parts of (B);
and (3) pentanediol: 1.0 part;
xanthan gum: 0.1 part;
gum arabic: 0.1 part;
the phase B comprises the following components in parts by weight:
glycosphingolipids: 1.0 part;
lecithin-coated sodium hyaluronate: 0.5 part;
fibronectin: 1.0 part;
the phase C comprises the following components in parts by weight:
1, 2-hexanediol: 1.0 part;
PEG-40 hydrogenated castor oil: 0.1 part;
essence for daily use: 0.01 part;
the balance is made up to 100 parts by deionized water.
Further measures taken are: the lecithin-coated sodium hyaluronate also comprises water and glycerol.
Further measures taken are: the ratio of the xanthan gum to the Arabic gum is 1: 1.
The invention also provides a preparation method of the moisturizing and repairing water, which comprises the following steps:
1) adding the phase A components in parts by weight into a vacuum closed container, heating in a water bath to 83-86 ℃, and stirring in vacuum for 15-25 minutes until the phase A components are completely dissolved to obtain a mixture A;
2) stopping stirring the mixture A, slowly cooling for the first time, setting the temperature of a water bath at 60-70 ℃, and standing and storing for 25-35 minutes;
3) cooling the mixture A for the second time, and setting the temperature of the water bath at 40-60 ℃ until the temperature of the mixture A is reduced to 43-47 ℃;
4) adding the components of the phase B in parts by weight into the mixture A after the step 3), and carrying out vacuum stirring until the components of the phase B are fully and uniformly mixed with the mixture A;
5) adding the C phase components in parts by weight into the A phase and B phase mixture obtained in the step 4), and stirring in vacuum for 25-35 minutes until A, B and the C phase are fully and uniformly mixed to obtain a semi-finished product B;
6) and (5) inspecting the semi-finished product B, discharging, storing in an aseptic environment, and filling to obtain a finished product.
Further measures taken are: the heating temperature of the water bath in the step 1) is 85 ℃; the standing and storing time of the mixture A in the step 2) is 30 minutes.
Wherein the glycosphingolipids like skin lipids can repair skin barrier and prevent transdermal water loss; the sodium hyaluronate wrapped by the phospholipid can promote the transdermal absorption of the sodium hyaluronate, improve the content of hyaluronic acid in a epidermal layer, promote the skin hydration and strengthen the skin moisturizing effect; fibronectin is widely involved in cell migration, adhesion, proliferation, hemostasis, tissue repair, etc., and can mobilize mononuclear phagocyte system to remove harmful substances from damaged tissue, and has growth factor effect.
Through the technical scheme, compared with the prior art, the invention has the following beneficial effects:
(1) the invention fully considers the interaction among the substances, and simultaneously carries out compatibility according to the characteristics and the proportion of each component, so that the components supplement each other, the obvious synergistic interaction function is achieved, and the invention has the obvious functions of relieving, moisturizing and repairing skin barriers.
(2) According to the invention, sodium hyaluronate is wrapped by lecithin to form a structure similar to skin lipid components, so that the penetration and absorption of active components are effectively promoted; meanwhile, fibronectin is added to further repair the skin, remove damaged tissues and promote the regeneration of the skin; and glycosphingolipids are effective in repairing skin barrier and enhancing skin barrier function.
(3) The preparation method provided by the invention can effectively protect the activity of each component, so that the raw materials can fully play a synergistic function, and the maximization of the effects of moisturizing, relieving and repairing skin barriers is achieved.
Detailed Description
In order to clearly understand the technical solutions adopted by the present invention, the following description is made on the preferred embodiments of the present invention, and it should be understood that the embodiments described herein are only used for illustrating and explaining the present invention, and are not used to limit the present invention.
Example 1: the moisturizing and repairing water comprises an A phase, a B phase and a C phase, wherein the A phase comprises the following components in parts by weight:
disodium EDTA: 0.01 part;
butanediol: 1.0 part;
glycerol: 2.0 parts of (B);
and (3) pentanediol: 1.0 part;
xanthan gum: 0.1 part;
gum arabic: 0.1 part;
the phase B comprises the following components in parts by weight:
glycosphingolipids: 1.0 part;
lecithin-coated sodium hyaluronate: 0.5 part;
fibronectin: 1.0 part;
the phase C comprises the following components in parts by weight:
1, 2-hexanediol: 1.0 part;
PEG-40 hydrogenated castor oil: 0.1 part;
essence for daily use: 0.01 part;
the balance is made up to 100 parts by deionized water.
And was prepared by the following experimental procedure:
1) adding the phase A components in parts by weight into a vacuum closed container, heating the mixture to 85 ℃ in a water bath, and stirring the mixture for 15 to 25 minutes in vacuum until the phase A components are completely dissolved to obtain a mixture A;
2) stopping stirring the mixture A, slowly cooling for the first time, setting the temperature of a water bath at 60-70 ℃, and standing and storing for 30 minutes;
3) cooling the mixture A for the second time, and setting the temperature of the water bath at 40-60 ℃ until the temperature of the mixture A is reduced to 43-47 ℃;
4) adding the components of the phase B in parts by weight into the mixture A after the step 3), and carrying out vacuum stirring until the components of the phase B are fully and uniformly mixed with the mixture A;
5) adding the C phase components in parts by weight into the A phase and B phase mixture obtained in the step 4), and stirring in vacuum for 25-35 minutes until A, B and the C phase are fully and uniformly mixed to obtain a semi-finished product B;
6) and (5) inspecting the semi-finished product B, discharging, storing in an aseptic environment, and filling to obtain a finished product 1.
Example 2: the moisturizing and repairing water comprises an A phase, a B phase and a C phase, wherein the A phase comprises the following components in parts by weight:
disodium EDTA: 0.02 part;
butanediol: 1.5 parts;
glycerol: 3.0 parts of (B);
and (3) pentanediol: 2.0 parts of (B);
xanthan gum: 0.3 part;
gum arabic: 0.3 part;
the phase B comprises the following components in parts by weight:
glycosphingolipids: 2.0 parts of (B);
lecithin-coated sodium hyaluronate: 1.0 part;
fibronectin: 1.5 parts;
the phase C comprises the following components in parts by weight:
1, 2-hexanediol: 2.0 parts of (B);
PEG-40 hydrogenated castor oil: 0.2 part;
essence for daily use: 0.02 part;
the balance is made up to 100 parts by deionized water.
And was prepared by the following experimental procedure:
1) adding the phase A components in parts by weight into a vacuum closed container, heating the mixture to 83 ℃ in a water bath, and stirring the mixture for 15 to 25 minutes in vacuum until the phase A components are completely dissolved to obtain a mixture A;
2) stopping stirring the mixture A, slowly cooling for the first time, setting the temperature of a water bath at 60-70 ℃, and standing and storing for 35 minutes;
3) cooling the mixture A for the second time, and setting the temperature of the water bath at 40-60 ℃ until the temperature of the mixture A is reduced to 43-47 ℃;
4) adding the components of the phase B in parts by weight into the mixture A after the step 3), and carrying out vacuum stirring until the components of the phase B are fully and uniformly mixed with the mixture A;
5) adding the C phase components in parts by weight into the A phase and B phase mixture obtained in the step 4), and stirring in vacuum for 25-35 minutes until A, B and the C phase are fully and uniformly mixed to obtain a semi-finished product B;
6) and (5) inspecting the semi-finished product B, discharging, storing in an aseptic environment, and filling to obtain a finished product 2.
Example 3: the moisturizing and repairing water comprises an A phase, a B phase and a C phase, wherein the A phase comprises the following components in parts by weight:
disodium EDTA: 0.03 part;
butanediol: 4.0 parts of (B);
glycerol: 4.0 parts of (B);
and (3) pentanediol: 6.0 parts of (B);
xanthan gum: 0.3 part;
gum arabic: 0.3 part;
the phase B comprises the following components in parts by weight:
glycosphingolipids: 3.0 parts of (B);
lecithin-coated sodium hyaluronate: 2.0 parts of (B);
fibronectin: 2.0 parts of (B);
the phase C comprises the following components in parts by weight:
1, 2-hexanediol: 2.0 parts of (B);
PEG-40 hydrogenated castor oil: 0.3 part;
essence for daily use: 0.03 part;
the balance is made up to 100 parts by deionized water.
And was prepared by the following experimental procedure:
1) adding the phase A components in parts by weight into a vacuum closed container, heating the mixture to 86 ℃ in a water bath, and stirring the mixture for 15 to 25 minutes in vacuum until the phase A components are completely dissolved to obtain a mixture A;
2) stopping stirring the mixture A, slowly cooling for the first time, setting the temperature of a water bath at 60-70 ℃, and standing and storing for 25 minutes;
3) cooling the mixture A for the second time, and setting the temperature of the water bath at 40-60 ℃ until the temperature of the mixture A is reduced to 43-47 ℃;
4) adding the components of the phase B in parts by weight into the mixture A after the step 3), and carrying out vacuum stirring until the components of the phase B are fully and uniformly mixed with the mixture A;
5) adding the C phase components in parts by weight into the A phase and B phase mixture obtained in the step 4), and stirring in vacuum for 25-35 minutes until A, B and the C phase are fully and uniformly mixed to obtain a semi-finished product B;
6) and (5) inspecting the semi-finished product B, discharging, storing in an aseptic environment, and filling to obtain a finished product 3.
In addition, the following moisturizing effect and skin barrier repair tests were performed using the essence 1, the essence 2 and the essence 3 prepared in example 1, example 2 and example 3, and two similar conventional essences purchased in the market as control essence 1 and control essence 2, respectively:
firstly, testing a test article: moisturizing water 1, moisturizing water 2 and moisturizing water 3 prepared according to the technical schemes of the embodiments 1 to 3, and 2 types of conventional moisturizing water purchased from the market are respectively named as control 1 and control 2.
II, the tested people group: in 200 healthy female volunteers 18-38 years old in the same area, the face of the subject has slight inflammation or allergy, is sensitive to skin, and has dry and desquamated face symptoms.
And thirdly, randomly distributing the volunteers into 10 groups from 1 to 10 groups of 20 persons, wherein the groups 1 to 5 are subjected to a moisturizing effect test, and the groups 6 to 10 are subjected to a skin barrier repair test.
Fourthly, an experimental method:
the volunteer subjects in groups 1 to 5 were applied to the face uniformly every night and morning after the face was cleaned, and the facial moisture content was tested 1, 2, and 4 hours after application, and the effect feedback and recording was performed.
6-10 volunteer subjects clean the face every night and morning, the face is uniformly smeared with essence samples corresponding to each group, the face skin roughness test is respectively carried out 1, 2 and 4 hours after the face is used, the effect feedback and the recording are carried out, and the skin activity state image data collected by a Vis iosScan VC98 image analyzer is adopted to obtain the skin average roughness R3, the skin average roughness R3 can be used for representing the overall roughness of a test area, and the larger the numerical value is, the rougher the skin is, and the worse the skin barrier is; conversely, a smaller value indicates a smoother skin and a better skin barrier, and the change in the value before and after use indicates the degree of repair of the skin barrier.
Fifthly, experimental results: one month usage records were collected and analyzed for summary data, with the experimental results as shown in tables 1 and 2 below:
table 1: analysis of skin moisturizing effect test results
Table 2: analysis of results of skin roughness repair test
Through the two tests, feedback is collected and data result analysis is carried out, and it can be obviously seen that the moisturizing lotion prepared by the invention has obvious moisturizing and relieving effects, reduces the skin roughness, further repairs the skin barrier, synchronously solves various problems of the face, can meet the high-efficiency and quick life rhythm of modern women, and is suitable for popularization and application.
The above description is only for the purpose of illustrating the technical solutions of the present invention and not for the purpose of limiting the same, and other modifications or equivalent substitutions made by those skilled in the art to the technical solutions of the present invention should be covered within the scope of the claims of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (7)
1. The moisturizing and repairing water is characterized by comprising an A phase, a B phase and a C phase, wherein the A phase comprises the following components in parts by weight:
deionized water: 77.0-93.0 parts;
disodium EDTA: 0.01-0.03 part;
butanediol: 1.0-4.0 parts;
glycerol: 1.0-4.0 parts;
and (3) pentanediol: 1.0-6.0 parts;
xanthan gum: 0.01-0.3 part;
gum arabic: 0.01-0.3 part;
the phase B comprises the following components in parts by weight:
glycosphingolipids: 1.0-3.0 parts;
lecithin-coated sodium hyaluronate: 0.5-2.0 parts;
fibronectin: 0.1-2.0 parts;
the phase C comprises the following components in parts by weight:
1, 2-hexanediol: 0.5-2.0 parts;
PEG-40 hydrogenated castor oil: 0.1-0.3 part;
essence for daily use: 0.01 to 0.03 portion.
2. The moisturizing conditioner as claimed in claim 1, wherein: the phase A comprises the following components in parts by weight:
deionized water: 86.0 to 93.0 portions;
disodium EDTA: 0.01-0.02 portion;
butanediol: 1.0-2.0 parts;
glycerol: 2.0-3.0 parts;
and (3) pentanediol: 1.0-3.0 parts;
xanthan gum: 0.1-0.3 part;
gum arabic: 0.1-0.3 part;
the phase B comprises the following components in parts by weight:
glycosphingolipids: 1.0-2.0 parts;
lecithin-coated sodium hyaluronate: 0.5-1.0 part;
fibronectin: 0.5-1.0 part;
the phase C comprises the following components in parts by weight:
1, 2-hexanediol: 1.0-2.0 parts;
PEG-40 hydrogenated castor oil: 0.1-0.2 parts;
essence for daily use: 0.01 to 0.02 portion.
3. The moisturizing conditioner as claimed in claim 2, wherein: the phase A comprises the following components in parts by weight:
disodium EDTA: 0.01 part;
butanediol: 1.0 part;
glycerol: 2.0 parts of (B);
and (3) pentanediol: 1.0 part;
xanthan gum: 0.1 part;
gum arabic: 0.1 part;
the phase B comprises the following components in parts by weight:
glycosphingolipids: 1.0 part;
lecithin-coated sodium hyaluronate: 0.5 part;
fibronectin: 1.0 part;
the phase C comprises the following components in parts by weight:
1, 2-hexanediol: 1.0 part;
PEG-40 hydrogenated castor oil: 0.1 part;
essence for daily use: 0.01 part;
the balance is made up to 100 parts by deionized water.
4. The moisturizing conditioner as claimed in claim 1, wherein: the lecithin-coated sodium hyaluronate also comprises water and glycerol.
5. The moisturizing conditioner as claimed in claim 1, wherein: the ratio of the xanthan gum to the Arabic gum is 1: 1.
6. The method for producing moisturizing conditioning water according to any of claims 1 to 5, comprising the steps of:
1) adding the phase A components in parts by weight into a vacuum closed container, heating in a water bath to 83-86 ℃, and stirring in vacuum for 15-25 minutes until the phase A components are completely dissolved to obtain a mixture A;
2) stopping stirring the mixture A, slowly cooling for the first time, setting the temperature of a water bath at 60-70 ℃, and standing and storing for 25-35 minutes;
3) cooling the mixture A for the second time, and setting the temperature of the water bath at 40-60 ℃ until the temperature of the mixture A is reduced to 43-47 ℃;
4) adding the components of the phase B in parts by weight into the mixture A after the step 3), and carrying out vacuum stirring until the components of the phase B are fully and uniformly mixed with the mixture A;
5) adding the C phase components in parts by weight into the A phase and B phase mixture obtained in the step 4), and stirring in vacuum for 25-35 minutes until A, B and the C phase are fully and uniformly mixed to obtain a semi-finished product B;
6) and (5) inspecting the semi-finished product B, discharging, storing in an aseptic environment, and filling to obtain a finished product.
7. The moisturizing conditioner as claimed in claim 6, wherein: the heating temperature of the water bath in the step 1) is 85 ℃; the standing and storing time of the mixture A in the step 2) is 30 minutes.
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Application publication date: 20200107 |