CN114306194B - Freckle-removing cosmetic composition and freckle-removing cream containing umbilical cord blood extract and preparation methods of freckle-removing cosmetic composition and freckle-removing cream - Google Patents
Freckle-removing cosmetic composition and freckle-removing cream containing umbilical cord blood extract and preparation methods of freckle-removing cosmetic composition and freckle-removing cream Download PDFInfo
- Publication number
- CN114306194B CN114306194B CN202111618678.2A CN202111618678A CN114306194B CN 114306194 B CN114306194 B CN 114306194B CN 202111618678 A CN202111618678 A CN 202111618678A CN 114306194 B CN114306194 B CN 114306194B
- Authority
- CN
- China
- Prior art keywords
- freckle
- parts
- cosmetic composition
- exosomes
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The invention relates to the technical field of cosmetics, and particularly discloses a freckle-removing cosmetic composition containing umbilical cord blood extract, a freckle-removing cream and a preparation method of the freckle-removing cosmetic composition. The freckle-removing cosmetic composition comprises the following raw materials in parts by weight: 5-15 parts of umbilical cord extract, 1-10 parts of hydrolyzed placenta extract, 0.5-1.5 parts of arbutin, 4-10 parts of pomegranate exosomes and 2-6 parts of polygonum cuspidatum exosomes. According to the invention, five components of the umbilical cord extract, the hydrolyzed placenta extract, the arbutin, the pomegranate exosome and the polygonum cuspidatum exosome are reasonably matched, so that the prepared freckle-removing cosmetic composition can play a role of synergistic interaction, and can achieve a stronger freckle-removing whitening effect, be mild and free of stimulation, and have high product safety.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a freckle-removing cosmetic composition containing umbilical cord blood extract, a freckle-removing cream and a preparation method thereof.
Background
The mottle is a spot having a color different from the surrounding color. Including freckle, black speck, chloasma, senile plaque, etc., and belongs to dyschromatosis skin diseases. Skin diseases, which are often brown or melanin-pigmented and damage-tolerant, are formed in the face due to the increase of skin melanin, are often aggravated after sunburn in cheek and forehead parts, and are often associated with pregnancy and long-term menstrual disorder in women.
Various methods for inhibiting melanin production, such as inhibiting tyrosinase activity, scavenging active oxygen or free radicals, reducing ultraviolet irradiation, preventing oxidation reaction, etc., are effective methods for reducing melanin formation. At present, various whitening and freckle-removing components are added into cosmetics to achieve the effect of reducing or eliminating freckles. The common whitening and freckle-removing components comprise arbutin and derivatives thereof, fruit acids, vitamin C and derivatives thereof, and the like, but the whitening and freckle-removing components have strong irritation and are easy to interfere with the normal physiological metabolism of the skin.
In 1988, broxmeyer first proved by experiments that umbilical cord blood is rich in hematopoietic stem cells, which are a group of cells with self-renewing, highly proliferating and multidirectional differentiation potential, and are "ancestor cells" and "omnipotent cells" that form various tissues and organs of human body. According to the development stage, the stem cells can be classified into embryonic stem cells and adult stem cells, and according to the differentiation potential, the stem cells can be classified into totipotent stem cells, pluripotent stem cells and monopotent stem cells. The stem cells not only can produce or secrete a large amount of bioactive factors, but also contain abundant bioactive substances, and the bioactive factors or substances of the stem cells can effectively regulate and control body cell signal transduction, activate the human stem cells, and further physiologically repair or replace body injury, pathological changes, aged cells and the like.
Therefore, the biological active factors generated by stem cell secretion or the biological active substances in the stem cells are utilized to activate the stem cells of the organism, and the stem cells of the organism are further physiologically repaired or replaced by the stem cells of the organism to damage, lesions and aging cells, so that the biological active factors or the biological active substances in the stem cells have wide application prospects in the fields of disease prevention and treatment, health care and beauty.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a freckle-removing cosmetic composition containing umbilical cord blood extract, a freckle-removing cream and a preparation method thereof. The composition has the advantages of low irritation, good speckle fading effect, high safety and the like.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
the invention provides a freckle-removing cosmetic composition containing umbilical cord blood extract, which comprises the following raw materials in parts by weight:
5-15 parts of umbilical cord extract, 1-10 parts of hydrolyzed placenta extract, 0.5-1.5 parts of arbutin, 4-10 parts of pomegranate exosomes and 2-6 parts of polygonum cuspidatum exosomes.
The freckle-removing cosmetic composition is compounded by adopting plant exosomes and traditional whitening components, solves the problems of poor safety and large irritation of the traditional whitening and freckle-removing active components, can improve the heat resistance, oxidation resistance and ultraviolet resistance of the whitening active components, and is safer, more stable and more efficient than other whitening and freckle-removing components.
Arbutin can inhibit tyrosinase activity, thereby inhibiting melanin production. In the invention, five components of the umbilical cord extract, the hydrolyzed placenta extract, the arbutin, the pomegranate exosome and the polygonum cuspidatum exosome are reasonably matched to play a role in synergy, so that the effects of stronger freckle removing and whitening can be achieved, and the whitening cream is mild and has no stimulation.
As a preferred embodiment of the freckle-removing cosmetic composition, the freckle-removing cosmetic composition comprises the following raw materials in parts by weight:
5-12 parts of umbilical cord extract, 1-8 parts of hydrolyzed placenta extract, 0.5-1.2 parts of arbutin, 4-8 parts of pomegranate exosomes and 2-5 parts of polygonum cuspidatum exosomes.
When the raw materials are in parts by weight, the prepared freckle-removing cosmetic composition has better freckle-removing and whitening effects, solves the problems of poor safety, large irritation and the like of arbutin components, and has strong comprehensive performance.
More preferably, the freckle-removing cosmetic composition comprises the following raw materials in parts by weight:
8 parts of umbilical cord extract, 5 parts of hydrolyzed placenta extract, 1 part of arbutin, 6 parts of pomegranate exosomes and 4 parts of polygonum cuspidatum exosomes.
As a preferred embodiment of the freckle-removing cosmetic composition, the preparation method of the pomegranate exosomes or the polygonum cuspidatum exosomes comprises the following steps:
1) Grinding the rhizome of red pomegranate or giant knotweed, adding PBS buffer solution, filtering, centrifuging, and taking supernatant;
2) The resulting supernatant was ultracentrifuged, and the pellet was resuspended in buffer and taken.
The prepared infrared pomegranate exosomes, the giant knotweed exosomes and the arbutin are compounded according to a specific proportion, so that the irritation of the arbutin can be reduced, and the skin allergy phenomenon can be reduced.
As a preferred embodiment of the spot-removing cosmetic composition of the present invention, the rotational speed of centrifugation in the step 1) is 8000rpm to 9500rpm; the rotational speed of the centrifugation in the step 1) is 8500rpm-10000rpm.
The invention also provides application of the freckle-removing cosmetic composition in preparing water, milk, essence and cream.
In addition, the invention also provides a freckle-removing cream which comprises the following components in percentage by weight:
the above cosmetic composition for removing speckle is 1-3%, skin conditioner 0.2-1%, humectant 5-15%, emulsifying agent 0.2-1%, antioxidant 0.5-1%, and water in balance.
The freckle-removing cream prepared by the invention has strong whitening and freckle-removing effects, is safe, has no stimulation and no cytotoxicity, and can comprehensively whiten and remove freckles from the whole process of melanin generation and metabolism, and is not easy to rebound.
As a preferred embodiment of the freckle-removing cream, the skin conditioner is at least one of dipotassium glycyrrhizinate and allantoin; the humectant is hydrogenated polyisobutene; the emulsifier is candelilla wax or cetostearyl alcohol; the antioxidant is p-hydroxyacetophenone.
The invention also provides a preparation method of the freckle-removing cream, which comprises the following steps:
s1, mixing the humectant, the emulsifier, the antioxidant and water to obtain a water phase material;
s2, cooling the water phase material, adding the freckle-removing cosmetic composition and the skin conditioner, mixing, and cooling to obtain the freckle-removing cream.
Compared with the prior art, the invention has the following beneficial effects:
according to the invention, five components of the umbilical cord extract, the hydrolyzed placenta extract, the arbutin, the pomegranate exosome and the polygonum cuspidatum exosome are reasonably matched, so that the prepared freckle-removing cosmetic composition can play a role in synergy, and can achieve a stronger freckle-removing whitening effect, and is mild and free of stimulation; meanwhile, the red pomegranate exosome, the giant knotweed exosome and the arbutin are compounded, so that the problems of poor safety, large irritation and the like of the arbutin component can be solved, the irritation of the composition to the skin is reduced, and the safety of the product is improved.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
In the following examples and comparative examples, the experimental methods used were conventional methods unless otherwise specified, and the materials, reagents and the like used, unless otherwise specified, were all commercially available.
The animal umbilical cord extract is derived from Shenzhen Ruigit Biotechnology Co., ltd, with CAS number 98654-16-1; the hydrolyzed placenta extract is obtained from Hangzhou Beirong biotechnology Co.
In the following examples and comparative examples, arbutin, skin conditioner, moisturizer, emulsifier, antioxidant are all the same commercial products.
The preparation method of the pomegranate exosomes and the giant knotweed exosomes comprises the following steps: grinding the rhizomes of the red pomegranates or the giant knotweed with a tissue grinder, dissolving with PBS (phosphate buffer solution) in a ratio of 1:100, filtering with gauze, centrifuging at 9000rpm for 60min, collecting supernatant, transferring the collected supernatant to an overspeed centrifuge tube, accurately balancing under the condition that the error is less than 0.001g, putting into the precooled overspeed centrifuge, and centrifuging at the temperature of 4 ℃ and the temperature of 9500 Xg for 70min. The supernatant was discarded, the pellet was retained and resuspended in PBS, and after trimming, centrifuged again at 9500 Xg for 70min at 4 ℃. After the end, the pellet was collected, resuspended in a small amount of PBS and stored in an ultra-low temperature freezer.
Example 1 cosmetic composition for resolving speckle
A cosmetic composition for removing freckle comprises the following raw materials: 5 parts of umbilical cord extract, 1 part of hydrolyzed placenta extract, 0.5 part of arbutin, 4 parts of pomegranate exosomes and 2 parts of polygonum cuspidatum exosomes.
Example 2 cosmetic composition for resolving speckle
A cosmetic composition for removing freckle comprises the following raw materials: 12 parts of umbilical cord extract, 8 parts of hydrolyzed placenta extract, 1.2 parts of arbutin, 8 parts of pomegranate exosomes and 5 parts of polygonum cuspidatum exosomes.
Example 3 cosmetic composition for resolving speckle
A cosmetic composition for removing freckle comprises the following raw materials: 15 parts of umbilical cord extract, 10 parts of hydrolyzed placenta extract, 1.5 parts of arbutin, 10 parts of pomegranate exosomes and 6 parts of polygonum cuspidatum exosomes.
Example 4 cosmetic composition for resolving speckle
A cosmetic composition for removing freckle comprises the following raw materials: 8 parts of umbilical cord extract, 5 parts of hydrolyzed placenta extract, 1 part of arbutin, 6 parts of pomegranate exosomes and 4 parts of polygonum cuspidatum exosomes.
Example 5 freckle-removing cream
A freckle-removing cream comprises the following components in percentage by weight:
2% of the freckle-removing cosmetic composition prepared in example 1, 0.5% of dipotassium glycyrrhizinate, 12% of hydrogenated polyisobutene, 0.6% of candelilla wax, 0.5% of p-hydroxyacetophenone and the balance of water.
The preparation method of the freckle-removing cream comprises the following steps:
s1, mixing hydrogenated polyisobutene, candelilla wax, p-hydroxyacetophenone and water, heating to 80-85 ℃ and continuously stirring to ensure that all components are fully and uniformly stirred to obtain a water phase material; preserving the temperature of the water phase material for 20 minutes, sterilizing, starting cooling water, wherein the temperature of the cooling water is 25 ℃, and continuously stirring;
s2, cooling the water phase material to 45 ℃, adding the freckle-removing cosmetic composition prepared in the example 1, mixing with dipotassium glycyrrhizinate, and cooling to obtain the freckle-removing cream.
Example 6 freckle-removing cream
A freckle-removing cream comprises the following components in percentage by weight:
2% of the freckle-removing cosmetic composition prepared in example 2, 0.5% of dipotassium glycyrrhizinate, 12% of hydrogenated polyisobutene, 0.6% of candelilla wax, 0.5% of p-hydroxyacetophenone and the balance of water.
The preparation method of the freckle-removing cream comprises the following steps:
s1, mixing hydrogenated polyisobutene, candelilla wax, p-hydroxyacetophenone and water, heating to 80-85 ℃ and continuously stirring to ensure that all components are fully and uniformly stirred to obtain a water phase material; preserving the temperature of the water phase material for 20 minutes, sterilizing, starting cooling water, wherein the temperature of the cooling water is 25 ℃, and continuously stirring;
s2, cooling the water phase material to 45 ℃, adding the freckle-removing cosmetic composition prepared in the example 2, mixing with dipotassium glycyrrhizinate, and cooling to obtain the freckle-removing cream.
Example 7 freckle-removing cream
A freckle-removing cream comprises the following components in percentage by weight:
2% of the freckle-removing cosmetic composition prepared in example 3, 0.5% of dipotassium glycyrrhizinate, 12% of hydrogenated polyisobutene, 0.6% of candelilla wax, 0.5% of p-hydroxyacetophenone and the balance of water.
The preparation method of the freckle-removing cream comprises the following steps:
s1, mixing hydrogenated polyisobutene, candelilla wax, p-hydroxyacetophenone and water, heating to 80-85 ℃ and continuously stirring to ensure that all components are fully and uniformly stirred to obtain a water phase material; preserving the temperature of the water phase material for 20 minutes, sterilizing, starting cooling water, wherein the temperature of the cooling water is 25 ℃, and continuously stirring;
s2, cooling the water phase material to 45 ℃, adding the freckle-removing cosmetic composition prepared in the example 3, mixing with dipotassium glycyrrhizinate, and cooling to obtain the freckle-removing cream.
Example 8 freckle-removing cream
A freckle-removing cream comprises the following components in percentage by weight:
2% of the freckle-removing cosmetic composition prepared in example 4, 0.5% of dipotassium glycyrrhizinate, 12% of hydrogenated polyisobutene, 0.6% of candelilla wax, 0.5% of p-hydroxyacetophenone and the balance of water.
The preparation method of the freckle-removing cream comprises the following steps:
s1, mixing hydrogenated polyisobutene, candelilla wax, p-hydroxyacetophenone and water, heating to 80-85 ℃ and continuously stirring to ensure that all components are fully and uniformly stirred to obtain a water phase material; preserving the temperature of the water phase material for 20 minutes, sterilizing, starting cooling water, wherein the temperature of the cooling water is 25 ℃, and continuously stirring;
s2, cooling the water phase material to 45 ℃, adding the freckle-removing cosmetic composition prepared in the example 4, mixing with dipotassium glycyrrhizinate, and cooling to obtain the freckle-removing cream.
Example 9 freckle-removing cream
A freckle-removing cream comprises the following components in percentage by weight:
1% of the freckle-removing cosmetic composition prepared in example 3, 0.2% of dipotassium glycyrrhizinate, 5% of hydrogenated polyisobutene, 0.2% of candelilla wax, 0.8% of p-hydroxyacetophenone and the balance of water.
The preparation method of the freckle-removing cream comprises the following steps:
s1, mixing hydrogenated polyisobutene, candelilla wax, p-hydroxyacetophenone and water, heating to 80-85 ℃ and continuously stirring to ensure that all components are fully and uniformly stirred to obtain a water phase material; preserving the temperature of the water phase material for 20 minutes, sterilizing, starting cooling water, wherein the temperature of the cooling water is 25 ℃, and continuously stirring;
s2, cooling the water phase material to 45 ℃, adding the freckle-removing cosmetic composition prepared in the example 3, mixing with dipotassium glycyrrhizinate, and cooling to obtain the freckle-removing cream.
Example 10 freckle-removing cream
A freckle-removing cream comprises the following components in percentage by weight:
the freckle-removing cosmetic composition prepared in example 3 comprises 3% of dipotassium glycyrrhizinate, 15% of hydrogenated polyisobutene, 1% of candelilla wax, 1% of p-hydroxyacetophenone and the balance of water.
The preparation method of the freckle-removing cream comprises the following steps:
s1, mixing hydrogenated polyisobutene, candelilla wax, p-hydroxyacetophenone and water, heating to 80-85 ℃ and continuously stirring to ensure that all components are fully and uniformly stirred to obtain a water phase material; preserving the temperature of the water phase material for 20 minutes, sterilizing, starting cooling water, wherein the temperature of the cooling water is 25 ℃, and continuously stirring;
s2, cooling the water phase material to 45 ℃, adding the freckle-removing cosmetic composition prepared in the example 3, mixing with dipotassium glycyrrhizinate, and cooling to obtain the freckle-removing cream.
Comparative example 1
The difference compared with example 7 is that the composition does not contain the infrared pomegranate exosomes and the giant knotweed exosomes, and the other raw materials and contents are the same as those in example 7.
Comparative example 2
The difference compared with example 7 is that the composition does not contain infrared pomegranate exosomes, and the rest raw materials and parts by weight are the same as those of example 7.
Comparative example 3
The difference compared with example 7 is that the composition does not contain the giant knotweed exosomes, and the other raw materials and contents are the same as those of example 7.
Comparative example 4
The difference compared with example 7 is that the weight part of the infrared pomegranate exosomes in the composition is 15 parts, and the rest raw materials and the content are the same as those in example 7.
Comparative example 5
The difference compared to example 7 is that the umbilical cord extract is not contained, and the remaining raw materials and contents are the same as in example 7.
Test example one, safety test
Skin irritation/corrosiveness of the products prepared in examples 5 to 10 and comparative examples 1 to 5 were tested according to the skin irritation/corrosiveness test method of the 2015 edition of the cosmetic safety technical Specification, 8 New Zealand rabbits were taken for each group, the back Mao Guaqu of the New Zealand rabbits was coated with the freckle removing cream multiple times on the skin of the New Zealand rabbits, and then, the skin of the mammal was subjected to local irritation or corrosiveness and the degree thereof, and the test results are shown in Table 1 below.
Skin irritation intensity was evaluated from the integrated mean with reference to: the integral mean value is 0-0.5 (less than or equal to 0.5) without stimulation; slightly stimulating the integral mean value to be 0.5-2.0 (less than or equal to 2.0); stimulating in integral mean value of 2.0-6.0 (less than or equal to 6.0); the integral mean value is 6.0-8.0 (less than or equal to 8.0) and the irritation is strong.
TABLE 1
From the data in Table 1, it is understood that the freckle removing cream prepared in examples 5 to 10 was non-irritating to skin irritation intensity in a plurality of skin irritation tests according to the evaluation criteria of skin irritation/corrosiveness test method of 2015 edition of cosmetic safety Specification. The freckle-removing cream prepared in the comparative example 1 does not contain the infrared pomegranate exosomes and the giant knotweed exosomes, and has strong irritation to the skin, so that the compound of the infrared pomegranate exosomes and the giant knotweed exosomes can harmonize the irritation of arbutin to the skin, and reduce skin allergy and other phenomena.
The freckle-removing cream prepared in the comparative examples 2-3 lacks the pomegranate exosomes or the polygonum cuspidatum exosomes, has small irritation to skin, and shows that the synergistic effect of the pomegranate exosomes and the polygonum cuspidatum exosomes can solve the problems of poor safety and large irritation of the traditional whitening and freckle-removing active ingredients.
Test example two, evaluation of human body irritation
The freckle removing creams prepared in examples 5 to 10 and comparative examples 1 to 3 were subjected to human body irritation test comparison test, and the specific experimental method is as follows:
1) 90 subjects with obvious color spots on the face are selected and divided into 8 groups of 10 subjects each, and the subjects clean the whole face;
2) For the facial stain parts, the faces of 8 groups of subjects were tested separately, one group for each of examples 5-10 and comparative examples 1-3;
3) The hot sense, the tingling sense and the redness are detected automatically after the use for 15 minutes;
4) The number of people who feel uncomfortable with the product was compared as shown in table 2 below.
TABLE 2
As can be seen from the data in Table 2, the freckle removing creams prepared in examples 5 to 10 have no irritation to skin, mild performance and high product safety.
The freckle removing cream prepared in the comparative example 1 does not contain the pomegranate exosomes and the polygonum cuspidatum exosomes, has strong irritation to skin, and partial skin of a subject is accompanied with symptoms such as heat sensation, stinging, redness and the like.
The freckle removing cream prepared in comparative examples 2-3 lacks the exosomes of punica granatum or the exosomes of polygonum cuspidatum, and has small irritation to skin.
Test example three, patch test
The test method comprises the following steps: the patch test method for detecting the safety of the human body adopts a 48-hour closed patch test.
The spot-removing creams prepared in examples 5 to 10 were weighed into spot testers at 20. Mu.g each, and a blank control group was set, and the control group was blank (without any substances). 30 healthy volunteers (students in school) were selected, aged 20-28 years, without allergic history (meeting 2007 standard of inclusion and exclusion of cosmetic hygiene). After the back of a subject is cleaned, the spot tester added with the spot removing cream is applied to the selected position of the back by using a non-irritating adhesive tape, and after the spot tester is applied, the spot tester is pressed by a finger slightly so as to be uniformly applied to the skin for 48 hours. Ordering the subject to keep the spot paste part dry within 48 hours, avoiding intense exercise, scratching the spot test part, long-time sunlight irradiation and the like. After 48 hours, the tester is removed and marked, after 0 minutes, the isobaric mark disappears, the judgment is carried out under sufficient light, and the return visit observation is carried out within 72 hours and 96 hours respectively.
Table 3 is a skin adverse reaction grading standard.
TABLE 3 Table 3
TABLE 4 skin adverse reaction results
From the experimental data in Table 4, it was found that examples 5 to 10 did not have serious adverse reactions, 30 subjects did not have positive reactions, and the results determined that the spot-removing creams prepared in examples 5 to 10 did not have adverse reactions to human bodies.
Through the findings in Table 4, the umbilical cord extract, the hydrolyzed placenta extract, the arbutin, the pomegranate exosomes and the giant knotweed exosomes are reasonably compounded, so that irritation to skin is not easy to generate, and the safety of the product is high.
Test example four, skin stain color measurement
Test purpose: to verify the stain-fading effect of the freckle-removing cream of the present invention, examples 5 to 10 and comparative examples 1 to 5 were tested.
The test method comprises the following steps: examples 5 to 10, comparative examples 1 to 5 and blank examples were used on the spot portion of the face of a person, respectively, 100 persons were tested for the blank examples without any treatment, one sample was used for each 10 persons, and L (gloss), b (melanin) of the spot portion of the skin was tested with a CK-PMA6CL400 skin tester, skin moisture was tested with a skin moisture tester Corneometer CM825, and L, b, skin moisture and skin wrinkles before use, 30 days, respectively, and the measured L value, b value and average value of skin moisture of each sample are shown in Table 5.
Δl=l (after 1 month of the run of the blank or example product) -L (before the start of the run).
Δb=b (before the start of the test) to b (after 1 month of the test in the blank or example product).
Subtracting the first detection data from the second detection data of the skin moisture to obtain the change condition of the skin moisture content, wherein the larger the data is, the higher the skin moisture content is.
TABLE 5
| Group/effect value | ΔL | Δb | Variation of moisture content |
| Example 5 | 25.69 | 30.75 | 7.07％ |
| Example 6 | 26.12 | 30.96 | 7.09％ |
| Example 7 | 28.73 | 35.01 | 7.16％ |
| Example 8 | 24.59 | 28.71 | 6.55％ |
| Example 9 | 27.89 | 34.54 | 7.01％ |
| Example 10 | 27.92 | 34.67 | 6.99％ |
| Comparative example 1 | 15.89 | 19.21 | 6.02％ |
| Comparative example 2 | 18.46 | 20.37 | 6.35％ |
| Comparative example 3 | 19.85 | 21.13 | 6.47％ |
| Comparative example 4 | 21.81 | 23.89 | 6.53％ |
| Comparative example 5 | 23.42 | 26.36 | 6.86％ |
| Blank group | 3.32 | 4.15 | 2.46％ |
As can be seen from the data in Table 5, the freckle removing creams prepared in examples 5 to 10 have a good effect on the spot fading, and more melanin is reduced, so that the skin is whitened with a good effect.
According to data, the addition of the infrared pomegranate exosome and the giant knotweed exosome in the freckle-removing cream can achieve the effect of fading spots, and meanwhile, the infrared pomegranate exosome and the giant knotweed exosome are matched with the umbilical cord extract, the hydrolyzed placenta extract and the arbutin in a specific proportion to achieve the synergistic effect, so that the freckle-removing and whitening effects of the freckle-removing cream are better.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present invention may be modified or substituted equally without departing from the spirit and scope of the technical solution of the present invention.
Claims (8)
1. The freckle-removing cosmetic composition containing the umbilical cord blood extract is characterized by comprising the following raw materials in parts by weight:
5-15 parts of umbilical cord extract, 1-10 parts of hydrolyzed placenta extract, 0.5-1.5 parts of arbutin, 4-10 parts of pomegranate exosomes and 2-6 parts of polygonum cuspidatum exosomes;
the preparation method of the pomegranate exosome or the polygonum cuspidatum exosome comprises the following steps:
1) Grinding the rhizome of red pomegranate or giant knotweed, adding PBS buffer solution, filtering, centrifuging, and taking supernatant;
2) The resulting supernatant was ultracentrifuged, and the pellet was resuspended in buffer and taken.
2. The speckle-removing cosmetic composition according to claim 1, comprising the following raw materials in parts by weight:
5-12 parts of umbilical cord extract, 1-8 parts of hydrolyzed placenta extract, 0.5-1.2 parts of arbutin, 4-8 parts of pomegranate exosomes and 2-5 parts of polygonum cuspidatum exosomes.
3. The speckle-removing cosmetic composition according to claim 1, comprising the following raw materials in parts by weight:
8 parts of umbilical cord extract, 5 parts of hydrolyzed placenta extract, 1 part of arbutin, 6 parts of pomegranate exosomes and 4 parts of polygonum cuspidatum exosomes.
4. The spot-removing cosmetic composition according to claim 1, wherein the rotational speed of centrifugation in step 1) is 8000rpm to 9500rpm; the rotational speed of the centrifugation in the step 1) is 8500rpm-10000rpm.
5. Use of the speckle-removing cosmetic composition according to any one of claims 1 to 4 for the preparation of water, milk, essence, cream.
6. The freckle-removing cream is characterized by comprising the following components in percentage by weight:
the speckle removing cosmetic composition according to any one of claims 1 to 5, wherein the composition comprises 1 to 3% of the speckle removing cosmetic composition, 0.2 to 1% of the skin conditioner, 5 to 15% of the humectant, 0.2 to 1% of the emulsifier, 0.5 to 1% of the antioxidant, and the balance being water.
7. The spot-removing cream of claim 6, wherein the skin conditioning agent is at least one of dipotassium glycyrrhizinate and allantoin; the humectant is hydrogenated polyisobutene; the emulsifier is candelilla wax or cetostearyl alcohol; the antioxidant is p-hydroxyacetophenone.
8. A method of preparing the freckle-removing cream of claim 6, comprising the steps of:
s1, mixing the humectant, the emulsifier, the antioxidant and water to obtain a water phase material;
s2, cooling the water phase material, adding the freckle-removing cosmetic composition according to any one of claims 1-5 and a skin conditioner, and mixing, and cooling to obtain the freckle-removing cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111618678.2A CN114306194B (en) | 2021-12-27 | 2021-12-27 | Freckle-removing cosmetic composition and freckle-removing cream containing umbilical cord blood extract and preparation methods of freckle-removing cosmetic composition and freckle-removing cream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111618678.2A CN114306194B (en) | 2021-12-27 | 2021-12-27 | Freckle-removing cosmetic composition and freckle-removing cream containing umbilical cord blood extract and preparation methods of freckle-removing cosmetic composition and freckle-removing cream |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114306194A CN114306194A (en) | 2022-04-12 |
| CN114306194B true CN114306194B (en) | 2023-09-15 |
Family
ID=81014914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111618678.2A Active CN114306194B (en) | 2021-12-27 | 2021-12-27 | Freckle-removing cosmetic composition and freckle-removing cream containing umbilical cord blood extract and preparation methods of freckle-removing cosmetic composition and freckle-removing cream |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114306194B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115161256B (en) * | 2022-06-20 | 2024-03-12 | 广州远想生物科技股份有限公司 | Polygonum cuspidatum suspension cells, exosomes thereof, and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103320490A (en) * | 2013-05-13 | 2013-09-25 | 程树军 | Screening method of safety and efficacy of skin antioxidants through use of a plurality of normal human skin cells |
| CN107213084A (en) * | 2017-05-27 | 2017-09-29 | 广州市千邦化妆品有限公司 | A kind of whitening spot-eliminating composition and cosmetics |
| CN110960478A (en) * | 2019-12-04 | 2020-04-07 | 广州博科健康科技集团有限公司 | Freckle-removing cream containing umbilical cord extract and preparation method thereof |
-
2021
- 2021-12-27 CN CN202111618678.2A patent/CN114306194B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103320490A (en) * | 2013-05-13 | 2013-09-25 | 程树军 | Screening method of safety and efficacy of skin antioxidants through use of a plurality of normal human skin cells |
| CN107213084A (en) * | 2017-05-27 | 2017-09-29 | 广州市千邦化妆品有限公司 | A kind of whitening spot-eliminating composition and cosmetics |
| CN110960478A (en) * | 2019-12-04 | 2020-04-07 | 广州博科健康科技集团有限公司 | Freckle-removing cream containing umbilical cord extract and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114306194A (en) | 2022-04-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2264877C (en) | Lip treatment containing live yeast cell derivative | |
| CN111249209A (en) | Moisturizing repair cream and preparation method thereof | |
| CN110585048B (en) | Composition with anti-saccharification and anti-oxidation functions and application thereof | |
| CN110115704B (en) | Enzyme composition and application thereof in cosmetics with whitening function | |
| KR100783063B1 (en) | Functional Cosmetic Composition Comprising oryzae Extract | |
| CN111956539A (en) | Anti-allergy soothing and skin barrier repairing essence cream | |
| CN110302121B (en) | Infant hip-protecting cream containing plant essence and preparation method thereof | |
| CN114306194B (en) | Freckle-removing cosmetic composition and freckle-removing cream containing umbilical cord blood extract and preparation methods of freckle-removing cosmetic composition and freckle-removing cream | |
| CN114099393B (en) | Composition with tightening and anti-aging effects and preparation method and application thereof | |
| CN104473860A (en) | Ganodermalucidumcollagen mask and preparation process thereof | |
| CN112236201B (en) | Use of extract of rosewood (BIXA ORELLANA) | |
| CN112603875A (en) | Sunscreen composition and application thereof | |
| CN116549373A (en) | Composition for balancing skin grease secretion and preparation method and application thereof | |
| CN116440048A (en) | Composite retinol composition and preparation method and application thereof | |
| CN113425661B (en) | Plant composition with cleaning and repairing effects and application thereof | |
| JP5855949B2 (en) | Keratin production promoter, hair dye and nail polish | |
| CN113413354A (en) | Active dressing with wound surface repairing and/or barrier regenerating effects, application of active dressing and skin repairing BB cream | |
| CN113181090A (en) | Essence containing anti-aging composition and preparation method thereof | |
| CN115282108B (en) | Composition with efficient relieving effect and application thereof | |
| TWI788019B (en) | Use of chamaemelum nobile extract for manufacturing skincare composition | |
| CN113384510B (en) | Fermented composition with anti-photoaging, relieving and cooling effects and preparation method and application thereof | |
| CN115813826B (en) | Compact anti-wrinkle composition and application thereof in cosmetics | |
| CN116459169B (en) | Anti-inflammatory moisturizing skin external composition and preparation method and application thereof | |
| CN112220704B (en) | Natural high SPF (specific pathogen free) sun-screening agent, preparation method thereof and application thereof in color cosmetics | |
| CN115721595A (en) | Body lotion and method for producing same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |