CN110302121B - Infant hip-protecting cream containing plant essence and preparation method thereof - Google Patents

Abstract

The invention discloses a baby hip-protecting cream containing plant essence and a preparation method thereof, wherein the baby hip-protecting cream comprises the following components in parts by weight: 60-90 parts of petrolatum, 5-15 parts of liquid paraffin, 2-10 parts of microcrystalline wax, 2-10 parts of camellia seed oil, 3-8 parts of zinc oxide, 0.1-1 part of antioxidant, 0.1-1 part of bisabolol, 1-5 parts of evening primrose oil, 0.01-1 part of olive fruit extract and 0.01-1 part of water; the antioxidant is tocopherol acetate, and the olive fruit extract contains olive polyphenols, especially hydroxytyrosol. The camellia seed oil, the evening primrose oil and the olive fruit extract are applied to products by adopting the modern extraction technology, and the infant excrement is isolated by utilizing the hydrophobic function of the grease, so that the skin is prevented from being stimulated; meanwhile, the skin care product has the functions of diminishing inflammation, resisting bacteria, relieving itching and resisting ammonia irritation, and enables the skin to return to a comfortable state.

Description

Infant hip-protecting cream containing plant essence and preparation method thereof

Technical Field

The invention relates to the field of skin care products, in particular to infant hip-protecting cream containing plant essence and a preparation method thereof.

Background

With the widespread use of the paper diapers in the market, the buttocks of infants are often subjected to irritant reaction due to contact with excrement (including urine and excrement), so that pruritus, allergic dermatitis, eczema and the like of the buttocks of the infants are caused, and diaper dermatitis of the newborn is commonly called as red buttocks. The reasons for this are that the skin of the infant is thinner and tender, sweat glands and sebaceous glands are not mature yet, sebum secretion is less, so that the resistance of the infant is weak, substances contacting with the skin are more easily absorbed and enter the skin, the infant is easily infected by bacteria, the infant is sensitive to external temperature change, and skin problems such as allergy, red swelling, red rash, blisters and the like are easily caused. The existing common method is to use talcum powder, but the talcum powder contains inorganic powder such as talcum powder, and is easy to block pores, and is easy to be inhaled by human bodies to cause health problems. The existing infant hip care cream in the market is few in variety, generally only has the function of forming a protective film on the surface of skin, avoiding discharged urine and feces, directly stimulating the skin, and cannot keep isolation for a long time, and the existing infant hip care cream cannot effectively relieve or treat the occurred red hip inflammation. The mother and infant market has increasingly greater demand for hip care creams.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide the infant hip-care cream containing the plant essence and the preparation method thereof, wherein the infant hip-care cream is safe and non-irritant, can achieve the effects of lasting isolation, effective nourishing and effective relieving and treating of inflammation of hip redness.

The invention is realized by the following technical scheme:

the infant hip-care cream containing plant essence comprises the following components in parts by mass: 60-90 parts of petrolatum, 5-15 parts of liquid paraffin, 3-8 parts of zinc oxide, 2-10 parts of microcrystalline wax, 2-10 parts of camellia seed oil, 1-5 parts of evening primrose oil, 0.1-1 part of antioxidant, 0.1-1 part of bisabolol, 0.01-1 part of olive fruit extract and 0.01-1 part of water.

Preferably, the antioxidant is tocopherol acetate. The camellia seed oil, the evening primrose oil and the like all contain unsaturated fatty acid, are easy to oxidize and deteriorate, can stabilize the quality of products and store stably, are efficient and non-irritant antioxidants, and are suitable for the skin of infants. The antioxidant can also be selected from grape polyphenols, coenzyme Q10, tea polyphenols, etc.

Preferably, the infant hip-care cream containing plant essence comprises the following components in parts by mass: 60-80 parts of petrolatum, 5-15 parts of liquid paraffin, 3-8 parts of microcrystalline wax, 3-8 parts of camellia seed oil, 3-8 parts of zinc oxide, 0.5-1 part of tocopherol acetate, 0.1-0.5 part of bisabolol, 1-5 parts of evening primrose oil, 0.1-1 part of olive fruit extract and 0.1-1 part of water.

Evening primrose oil is oil rich in various unsaturated fatty acids, the unsaturated fatty acids account for 91.2 percent, more than 70 percent of linoleic acid and about 9 percent of gamma-linolenic acid are contained in the evening primrose oil, the evening primrose oil is rare in other oil, can be directly used as nutritional health-care oil and nutritional blend oil on nutritional food, and can also be added into other food to produce functional health-care food. Wherein, the gamma-linolenic acid is a highly unsaturated fatty acid which can not be synthesized by human body and has important physiological activity, is an important nutrient substance, and the final product of the gamma-linolenic acid metabolized in the organism has obvious curative effects of resisting thrombus, resisting inflammation, inhibiting the growth of cancer cells, reducing serum cholesterol, treating atherosclerosis and the like. If the skin is deficient, the skin metabolism can be disturbed, and rash can occur. Oenothera biennis oil is externally applied to the surface of skin, can regulate the cellular metabolism of the skin and the secretion of sebaceous glands, brings elasticity to the skin and promotes the regeneration function. The evening primrose is used for skin care products, has no stimulation to skin, good skin feeling and strong stability, and particularly can supplement skin nutrient components and promote skin metabolism and regeneration; when used in aromatherapy, evening primrose oil can blend lotion and cream, improve eczema and psoriasis, and help wound healing.

The bisabolol has pharmacological effects of resisting inflammation, diminishing inflammation, resisting bacteria, relieving itching, relieving pain, relieving swelling, promoting cell regeneration and wound healing.

The zinc oxide has anti-inflammatory, drying, adsorbing, and astringent effects, and has mild and non-irritating properties, and has effects of protecting skin, reducing friction, and preventing external irritation. Clinical medicine shows that the zinc oxide has quick response to the treatment of the infantile eczema, no side effect, difficult relapse after healing and high cost performance.

The camellia oil is extracted from camellia oleifera fruits of woody oil plants, is one of four famous woody plant oils in the world and is the most healthy plant oil acknowledged by the international health organization, contains 90 percent of unsaturated fatty acid, mainly contains oleic acid and linoleic acid, so the camellia oil has good skin feel, is fresh and cool, is not greasy, is quickly absorbed and has good moisturizing property, and can increase the brightness and luster of a coated part. Ancient literature, the whole agricultural government book, compendium supplement records that tea seed oil has the effects of moistening intestines, clearing stomach, sterilizing, detoxifying, clearing liver, reducing fire, accelerating wound healing and the like.

Preferably, the olive fruit extract contains olive polyphenols.

Preferably, the olive polyphenols comprise hydroxytyrosol.

The olive has various biological and pharmacological activities of heart health enhancement, cancer resistance, bacteria resistance, inflammation resistance and the like, modern biotechnology analysis shows that active substances in the olive mainly comprise olive polyphenol, flavonoid, secoiridoid (including olive kupu), biflavone and the like, and many experiments prove that the olive polyphenol extract has strong free radical scavenging capacity and high antioxidant activity. The antioxidant property of the olive polyphenol is a comprehensive effect, the antioxidant property of the olive polyphenol mainly comes from a large amount of hydroxytyrosol in polyphenol molecules, two phenolic hydroxyl groups are arranged on the hydroxytyrosol molecules, in addition, one alcoholic hydroxyl group is also arranged on the hydroxytyrosol molecules, the olive polyphenol is an amphoteric molecule with the phenolic hydroxyl group characteristic and the alcoholic hydroxyl group characteristic, the olive polyphenol has strong antioxidant effect, and exogenous and endogenous oxides and free radicals can be effectively removed by controlling the oxidation of a plurality of unsaturated fatty acids. Meanwhile, the olive extract containing olive polyphenol (represented by hydroxytyrosol) also has strong and unique effects of diminishing inflammation, relieving pain, resisting bacteria, resisting viruses and the like, and can effectively relieve various skin diseases such as eczema, psoriasis and allergic dermatitis; the composition has good inhibition effect on enzyme, can promote skin metabolism by maintaining healthy blood sugar metabolism, promotes wound healing, and effectively enhances skin elasticity.

More importantly, the olive fruit extract has a specific anti-ammonia stimulation effect, and tests prove that the olive fruit extract has better effect than general anti-allergic components in 2 days, 3 days and 7 days of erythema generation induced and stimulated by ammonia at the concentration of 0.5 percent.

The preparation method of the infant hip-care cream containing the plant essence comprises the following steps:

A) weighing mineral ester, liquid paraffin and microcrystalline wax, adding into a production cylinder, heating while stirring until dissolving;

B) cooling to 60-70 ℃, then adding camellia seed oil, zinc oxide, tocopheryl acetate or vitamin E, bisabolol and evening primrose oil, uniformly stirring, and continuously cooling to 40-45 ℃;

C) stirring and dissolving water and olive fruit extract in a clean container, adding into the production cylinder in the step B), stirring, inspecting, and discharging.

The main reasons for the red buttocks of the baby are that the diaper can not be frequently and timely replaced, the buttocks are sultry, moist and airtight, the buttocks of the baby can be stimulated when the diaper is soaked for a long time in the presence of urine, the moist buttocks are easy to be damaged, and the diaper rubs with the buttocks for a long time to cause the red buttocks.

The invention adopts the inert grease to form the protective film on the surface layer of the skin, thereby achieving the isolation of the excrement of the baby, avoiding the skin from being stimulated and reducing the friction of the paper diaper on the skin; meanwhile, the camellia seed oil, the evening primrose oil and the olive fruit extract are applied to products by combining the traditional ancient herbal formula and adopting the modern extraction technology, and the natural protective barrier is constructed by utilizing the active ingredients of the natural oil, so that the skin barrier function is improved, the skin is durably and effectively moistened, and the drying and cracking are prevented; meanwhile, the skin care product has the functions of diminishing inflammation, resisting bacteria, relieving itching and resisting ammonia irritation, and enables the skin to return to a comfortable state. In addition, the product contains zinc oxide, and has antibacterial, antiinflammatory, astringent and skin repairing effects.

The natural plant effective components used in the formula are safe and effective substances, are mild and hormone-free, are suitable for babies, and particularly, the evening primrose oil is an extremely safe and effective nutrient, is easy to be absorbed by skin after being used, and has the effects of promoting blood circulation, resisting inflammation, preventing freezing and the like; the method is high in pertinence and specially developed for infants, and symptoms such as redness and pruritus of the buttocks of the infants are solved in multiple dimensions, so that redness and inflammation of the buttocks of the infants are prevented; the synergistic effect of a plurality of effective components improves the effect, and simultaneously can reduce the dosage of certain high-price components and reduce the cost; the product has soft and moist texture and is easy to apply; the use is convenient, and the right amount of the lotion can be taken and is gently and uniformly smeared on the clean and dry buttocks of the infant.

Detailed Description

The components and the use amounts of the infant hip-care cream containing plant essences in the embodiments 1 to 4 of the invention are shown in the following table 1:

TABLE 1 baby hip-care cream composition formula (unit: parts) described in examples 1 to 4 of an antibacterial repairing

Components	Example 1	Example 2	Example 3	Example 4
					Petrolatum	66	73.9	77.3	60
Liquid paraffin	10	8	5	14.1
					Microcrystalline wax	6	5	3	8
Camellia seed oil	8	3	5	6
					Zinc oxide	6	5	4	7
Bisabolol	0.3	0.2	0.3	0.2
					Evening primrose oil	2	4	4	3
Olea europaea extract	0.4	0.1	0.2	0.3
					Tocopherol acetate	0.5	0.6	0.8	0.8
Water (W)	0.8	0.2	0.4	0.6

The olive fruit extract is obtained from Guangzhou Baihabo Co, Ltd or Guangzhou Noron Biotech Co., Ltd (batch No. 19052113), and may be the same product from other manufacturers; zinc oxide was purchased from Merck, Germany, vitamin E from Pasteur, and evening primrose oil from Guangzhou blue reputation trade company, Inc.

The preparation method of the infant hip protection cream containing plant essence provided by the embodiment 1-4 of the invention comprises the following steps:

(1) weighing mineral ester, liquid paraffin and microcrystalline wax, adding into a production cylinder, heating while stirring until dissolving;

(2) cooling to 60-70 ℃, then adding camellia oil, zinc oxide, tocopheryl acetate, bisabolol and evening primrose oil, stirring uniformly, and continuously cooling to 40-45 ℃;

(3) and (3) stirring and dissolving the water and the olive fruit extract uniformly in a clean container, adding the mixture into the production cylinder in the step (2), stirring uniformly, and discharging after the inspection is qualified.

The basic conditions of the control groups 1 to 9 are shown in Table 2.

TABLE 2 basic conditions of control 1-9 products

	Manufacturer of the product	Product traits
			Control group 1	Japanese Brand	Pure oil type
Control group 2	American Brand	W/O type
			Control group 3	British brand	O/W type
Control group 4	Danish brand	O/W type
			Control group 5	American Brand	W/O type
Control group 6	Domestic brand	O/W type
			Control group 7	British brand	W/O type
Control group 8	Domestic brand	Pure oil type
			Control group 9	German brand	W/O type

And (3) performance testing:

1. basic index test

The product prepared in this example is W/O type, and is milky white paste. The test was carried out according to QB/T1857-2013, and the test results are shown in Table 3.

TABLE 3 basic indexes of products of examples 1 to 4

2. Isolation effect test method

The test and judgment method comprises the following steps: the hip protection product (0.4g, namely just fully spreading the filter paper) is coated on the surface of 1/4 filter paper, 0.4g of 0.85% physiological saline is dripped, whether the filter paper can form a protective film to isolate the physiological saline or not is observed at different times, and whether the filter paper coated with the hip protection cream is wetted or not is observed. If the filter paper is not wet and shows obvious water drops, the hip pad product is proved to have excellent urine isolation effect; if the filter paper is wet and no water drop is formed, the urine isolating effect of the hip pad product is poor; the evaluation results are classified into four grades of poor, general, good and excellent.

The test results are shown in Table 4.

TABLE 4 isolation Effect of examples 1-4 and control groups 1-9

3. Test of Water-proof Effect

Under the same temperature and humidity condition, 0.05mg of hip protection product is uniformly coated in a square area of 3.0cm x3.0cm inside an arm of a tester (not less than 5), a dropper is used for spreading distilled water in the area until the distilled water does not flow down, after the distilled water is absorbed by a paper towel after 5 minutes of stabilization, the moisture content of the skin in the area is immediately tested by a skin moisture meter, if the moisture content is high, the waterproof effect is poor, and if the moisture content is relatively low, the waterproof effect is good. The test results are shown in Table 5.

TABLE 5 waterproof effect (temperature 25 ℃ C., relative humidity 50%) of examples 1 to 4 and control groups 1 to 9

	Skin moisture content (%)
		Example 1	43.7
Example 2	44.6
		Example 3	45.5
Example 4	43.9
		Control group 1	45.2
Control group 2	48.6
		Control group 3	68.3
Control group 4	68.5
		Control group 5	50.3
Control group 6	65.6
		Control group 7	53.3
Control group 8	44.3
		Control group 9	56.7

The waterproof effect is respectively: example 1> example 4> control 8> example 2> control 1> example 3> control 2> control 5> control 7> control 9> control 6 ≈ control 4 ≈ control 3.

W/O system coating lightness and thinness

The product of this example is a W/O system, and for the sake of fairness, the coating lightness and thinness of the product were tested for the examples and the control group of the W/O system. By adopting a sensory evaluation method of testers, 0.05mg of the hip pad product is uniformly coated in a square area which is 3.0cm x3.0cm on the inner side of the arms of the testers (not less than 5), the weight bearing feeling of the skin of the testers is evaluated in a sensory mode, the weight bearing feeling is graded by 1-10 points, the skin feeling is light and thin without greasy burden feeling by 10 points, and the average value of the testers is taken. The test results are shown in Table 6.

TABLE 6 WO System examples and control smear lightness

	Score of
		Example 1	7.8
Example 2	8.0
		Example 3	7.5
Example 4	8.5
		Control group 2	8.3
Control group 5	5.5
		Control group 7	6.8
Control group 9	7.5

As can be seen from table 6, the order of lightness and thinness of the coating is: example 4> control 2> example 1> example 3 ═ control 9> control 7> control 5.

Spreadability of the W/O System

As above, the examples of the W/O system and the control were tested for spreadability, i.e., whether the pasty product could be easily and evenly pushed aside. The product is automatically picked up by the fingers of the testers, the product is smeared on the skin according to the use habits of all people, the product is scored according to the sensory contrast, 1-10 points are scored, 10 points are very easy to uniformly push the product on the skin, and the average value of the testers is taken. The test results are shown in Table 7.

TABLE 7 spreadability of examples of the W/O System and of the control

As can be seen from Table 7, the order of superiority and inferiority of the spreadability was: example 1> example 4> example 2 ═ control 2> example 3> control 5> control 7> control 9.

6. Clinical testing

A total of 40 bottles of the product of the invention are sent to Beijing Sanlihui appraisal cosmetics science and technology company for clinical evaluation.

The test purpose is as follows: evaluating the improvement effect of the test sample on the baby hip redness phenomenon;

the number of subjects: 30 persons;

sex of the subjects: 13 women, 17 men;

age of subject: 0-2 years old;

test area: a hip flush zone;

and (3) testing period: 5 days;

skin color test (Chromameter): the skin color was tested using a skin spectrophotometer Chromameter (CM-700D, Konica Minolta, japan). The skin color was characterized using the Lab color system specified by the International Commission on illumination (CIE). Wherein L is^*Is brightness, a^*Is the degree of red and green, b^*The blue-yellow color can reflect the change of skin color degree through comprehensive evaluation of the three, a^*Can reflect the redness of skin, a^*Larger indicates redder skin. Use of a in this test^*As a parameter for evaluating the degree of redness of the buttocks.

Skin imaging test (Tivi): the skin sensitivity tester Tivi (Wheels Bridge, sweden) quantitatively analyzes the concentration of red blood cells by using the absorption characteristics of red blood cells to green light, and generates an image according to the analysis test result, wherein the skin sensitivity is represented by color in the image. The closer the image color is to the right of the scale, the more severe the skin redness is.

The product of the invention is used for evaluating the improvement effect of the test sample on the baby hip redness phenomenon through human body trial for 5 consecutive days (2 subjects quit the test during the test period) and comparing with the test sample before use, and the specific conditions are as follows:

a total of 30 subjects participated in the test, during which the test subjects used the samples daily in the hip red area for 5 consecutive days, and skin color tests were carried out on the test area before (initial) use of the samples, after 1, 3 and 5 days of use of the samples, skin color parameter a^*The test results are shown in Table 8.

TABLE 8 skin color a before, after, 1, 3 and 5 days of use^*Mean and statistical results

The improvement degree of the hip redness phenomenon is evaluated by a doctor according to a hip imaging Tivi picture and displayed by a score, the test result is shown in a table 9, and the higher the average score is, the more obvious the improvement effect is.

Table 9 statistics of skin condition improvement after 1 day, 3 days and 5 days of sample application (n ═ 28)

From the above results, the skin color test resultsShows that the skin color parameter a is 1 day, 3 days and 5 days after use compared to before use^*The values are all significantly reduced (P)<0.05), the reduction rates were 10.9%, 17.7% and 23.2% in this order.

The results of the doctor evaluation showed a gradual improvement in the hip redness after 1, 3 and 5 days of use compared to before use, with statistically significant changes (P < 0.05).

In combination with the above analysis, the baby hip-care cream showed an effect of improving the baby's hip-redness phenomenon in a test period of 5 days, compared to before use.

The above detailed description is specific to possible embodiments of the present invention, and the embodiments are not intended to limit the scope of the present invention, and all equivalent implementations or modifications that do not depart from the scope of the present invention are intended to be included within the scope of the present invention.

Claims (4)

1. The infant hip-care cream containing plant essence is characterized by comprising the following components in parts by mass: 60-90 parts of petrolatum, 5-15 parts of liquid paraffin, 3-8 parts of zinc oxide, 2-10 parts of microcrystalline wax, 2-10 parts of camellia seed oil, 1-5 parts of evening primrose oil, 0.1-1 part of antioxidant, 0.1-1 part of bisabolol, 0.01-1 part of olive fruit extract and 0.01-1 part of water;

the olive fruit extract contains olive polyphenols; the olive polyphenols comprise hydroxytyrosol.

2. The infant hip cream containing plant essence according to claim 1, wherein the antioxidant is tocopherol acetate.

3. The infant hip-care cream containing plant essence is characterized by comprising the following components in parts by mass: 60-80 parts of petrolatum, 5-15 parts of liquid paraffin, 3-8 parts of zinc oxide, 3-8 parts of microcrystalline wax, 3-8 parts of camellia seed oil, 1-5 parts of evening primrose oil, 0.5-1 part of tocopherol acetate, 0.1-0.5 part of bisabolol, 0.1-1 part of olive fruit extract and 0.1-1 part of water.

4. A method for preparing the baby hip-care cream containing plant essence according to any one of claims 2 to 3, which comprises the following steps:

A) weighing petrolatum, liquid paraffin and microcrystalline wax, adding into a production cylinder, heating while stirring until the petrolatum, the liquid paraffin and the microcrystalline wax are dissolved;

B) cooling to 60-70 ℃, then adding camellia oil, zinc oxide, antioxidant, bisabolol and evening primrose oil, stirring uniformly, and continuously cooling to 40-45 ℃;

C) stirring and dissolving water and olive fruit extract in a clean container, adding into the production cylinder in the step B), stirring, inspecting, and discharging.