CN111557867B - Infant soothing cream and preparation method thereof - Google Patents
Infant soothing cream and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses an infant soothing cream and a preparation method thereof. The infant soothing cream disclosed by the invention comprises the following components in percentage by mass: thickening and stabilizing agent: 10% -30%; skin conditioner: 0.06% -0.55%; anti-allergic agent: 0.1% -2%; antioxidant: 0.1% -2%; and (3) an emollient: the balance; the emollient is composed of camellia seed oil, lithospermum oil, olive oil and peppermint oil. The preparation method of the infant soothing cream is simple, and the infant soothing cream is prepared by heating and mixing all the components in batches uniformly and then freezing to form the cream. The infant soothing cream disclosed by the invention has multiple effects of resisting inflammation, repairing, relieving itching, calming and the like, is safe and non-irritant, and can be used for effectively preventing and treating skin problems of eczema, oral water eruption, mosquito bites on red bags, bruise and the like of infants.
Description
Technical Field
The invention relates to an infant soothing cream and a preparation method thereof, and belongs to the technical field of skin care products.
Background
The skin is the largest organ of human body organs and has multiple functions of protecting, excreting, regulating body temperature, sensing external stimulation and the like. The skin of infants is delicate, especially the newborn has not developed completely because the horny layer, sweat glands, blood vessels and the like of the epidermis, the defense force of the skin is relatively weak, and certain skin diseases are easily generated. Infant skin is often prone to the following problems: 1) Eruption including eczema, oral rash, red buttocks and red spots after fever; 2) Chapped and skinned skin appears when the weather is dry in autumn and winter; 3) Erythema and pruritus appear on the skin after being bitten by mosquitoes in spring and summer; 4) Erythema and bruise of the skin caused by the collision.
At present, commercially available infant skin care products have single functions, mainly moisten and moisturize, and hardly have any effect on common skin diseases of infants, such as eruption, erythema and the like. Therefore, there is a need to develop a skin care product with anti-inflammatory, repairing, antipruritic and sedative effects.
Disclosure of Invention
The invention aims to provide an infant soothing cream and a preparation method thereof.
The technical scheme adopted by the invention is as follows:
the infant soothing cream comprises the following components in percentage by mass:
thickening and stabilizing agent: 10% -30%;
skin conditioner: 0.06% -0.55%;
anti-allergic agent: 0.1% -2%;
antioxidant: 0.1% -2%;
and (3) an emollient: the balance;
the emollient is composed of camellia seed oil, lithospermum oil, olive oil and peppermint oil.
Preferably, the infant soothing cream comprises the following components in percentage by mass:
thickening and stabilizing agent: 10% -25%;
skin conditioner: 0.06 percent to 0.5 percent;
anti-allergic agent: 0.1 to 1 percent;
antioxidant: 0.1 to 1 percent;
and (3) an emollient: the balance;
the emollient is composed of camellia seed oil, lithospermum oil, olive oil and peppermint oil.
Preferably, the thickening stabilizer is at least one of beeswax, candelilla wax and hydrogenated olive oil.
Further preferably, the thickening stabilizer is prepared from beeswax, candelilla wax and hydrogenated olive oil according to the mass ratio of (5-15): (3-9): (2-6).
More preferably, the thickening stabilizer is prepared from beeswax, candelilla wax and hydrogenated olive oil according to the mass ratio of (5-12): (3-8): (2-5).
Preferably, the skin conditioner is at least one of bisabolol and paeonol.
Further preferably, the skin conditioner is prepared from bisabolol and paeonol according to a mass ratio of (5-50): (1-5).
More preferably, the skin conditioner is prepared from bisabolol and paeonol according to a mass ratio of (5-45): (1.5-5).
Preferably, the anti-allergic agent consists of oat alkaloid, ascorbyl palmitate, 1, 2-pentanediol and 1, 2-butanediol (1, 2-pentanediol and 1, 2-butanediol are used as solvents, and ascorbyl palmitate is used as a stabilizer).
Preferably, the antioxidant is tocopherol.
Preferably, the emollient is prepared from camellia seed oil, lithospermum oil, olive fruit oil and mint oil according to the mass ratio (33-39): (12-20): (27-29): (0.2-2).
Preferably, the camellia seed oil is prepared by cold pressing camellia seeds.
Preferably, the lithospermum oil is prepared by soaking lithospermum in camellia seed oil.
Preferably, the olive fruit oil is prepared by cold pressing olive fruits.
Preferably, the peppermint oil is obtained by steam distillation of stems and leaves of peppermint.
The preparation method of the infant soothing cream comprises the following steps: heating and stirring thickening stabilizer, adding emollient, heating and stirring, adding skin conditioner, anti-allergy agent and antioxidant, heating and stirring, cooling, and freezing to obtain ointment.
Preferably, the heating and stirring temperature is 75-85 ℃.
The invention has the beneficial effects that: the infant soothing cream disclosed by the invention has various effects of resisting inflammation, repairing, relieving itching, calming and the like, is safe and non-irritant, and can be used for effectively preventing and treating skin problems of eczema, oral water eruption, mosquito bites on red bags, bruise and the like of infants.
Specifically, the method comprises the following steps:
1) The camellia seed oil is added into the infant soothing cream, is rich in various functional components such as unsaturated fatty acid, camellin, tea polyphenol, squalene, vitamins and the like, has good affinity with skin, is easy to be absorbed by the skin, has multiple effects of sterilizing and resisting bacteria, clearing heat and eliminating dampness, diminishing inflammation and relieving itching and the like, and is particularly suitable for solving the problems of infant eczema, diaper rash, oral water rash, mosquito bites and red bags and the like;
2) The lithospermum oil is added into the infant soothing cream, and is prepared by taking camellia seed oil as base oil to soak lithospermum, so that the infant soothing cream can effectively repair and relieve skin diseases such as infantile eczema, saliva rash, diaper rash and the like;
3) The olive fruit oil is added into the infant soothing cream, so that the skin elasticity can be effectively enhanced, the damaged skin can be moisturized and repaired, the moisturizing and repairing effects on skin diseases such as eczema, oral eczema, diaper rash and the like of infants can be achieved, and the barrier function of the skin can be enhanced;
4) The mint oil is added into the infant soothing cream, so that the infant soothing cream can dispel wind and heat, calm and relieve itching, is particularly suitable for measles without adequate eruption and rubella itching, can relieve itching intolerance of infants caused by skin diseases such as eczema, saliva rash and diaper rash in time, plays a role in calming and soothing, and prevents the skin diseases of infants from further worsening due to scratching of the infants caused by the itching;
5) According to the invention, the camellia seed oil, the lithospermum oil, the olive oil and the peppermint oil are matched for use, so that a synergistic effect can be achieved, and the anti-inflammatory, repairing, itching relieving and tranquilizing effects are further improved;
6) The beeswax is added into the infant soothing cream, so that a formula system can be stabilized, the effect of thickening and stabilizing grease is achieved, the rich antibacterial components have the effects of inhibiting and killing various pathogenic bacteria, and the infant soothing cream can effectively resist bacteria and diminish inflammation;
7) The candelilla wax is added into the infant soothing cream, so that the infant soothing cream not only has the functions of solidification, thickening and stabilization, but also can improve the heat-resistant stability of a product and enhance the stability of the product;
8) The hydrogenated olive oil is added into the infant soothing cream, so that the hardness of the cream can be enhanced, the surface of the cream is dry and smooth without oil, the stability of a product can be enhanced, the heat-resistant stability of the product is improved, and the infant soothing cream is convenient to transport and use in daily life;
9) The infant soothing cream disclosed by the invention is added with bisabolol, has anti-inflammatory and antibacterial effects, has good compatibility with skin, can reduce skin inflammation, relieve skin acne, prevent acne, improve the anti-irritation capacity of the skin, repair the skin with inflammation injury, and has good effects on skin diseases such as eczema, oral eczema, diaper rash and the like;
10 The baby soothing cream disclosed by the invention is added with paeonol, has the effects of inhibiting bacteria, resisting inflammation, relieving pain, resisting allergy, enhancing immunity and the like, and has very good repairing, antibacterial and anti-inflammatory effects on skin diseases such as infantile eczema, saliva rash, diaper rash and the like;
11 The infant soothing cream disclosed by the invention is added with the oat alkaloid, so that skin abnormal conditions caused by histamine, such as pruritus, redness and swelling, blisters and the like, can be obviously relieved, skin dryness symptoms and skin pruritus caused by the skin dryness symptoms can be relieved, and soothing and anti-inflammatory effects are realized on skin diseases such as infant eczema, oral eczema, diaper rash and the like;
12 Tocopherol is added into the infant soothing cream, so that the infant soothing cream has excellent antioxidation, is natural and environment-friendly, and can stabilize products without rancidity and flavor change.
Detailed Description
The invention will be further explained and illustrated with reference to specific examples.
Examples 1 to 3:
the infant soothing cream comprises the following raw materials in percentage by weight:
TABLE 1 raw materials composition table of soothing cream for infants
The preparation method of the infant soothing cream comprises the following steps:
stirring thickening stabilizer at 85 deg.C, adding emollient, stirring at 75 deg.C, adding skin conditioner, anti-allergy agent and antioxidant, stirring at 75 deg.C, cooling to 65 deg.C, and freezing to obtain ointment.
Comparative examples 1 to 7:
the infant soothing cream comprises the following raw materials in percentage by weight:
TABLE 2 raw materials of soothing cream for infants
The preparation method of the infant soothing cream comprises the following steps:
stirring thickening stabilizer at 85 deg.C, adding emollient, stirring at 75 deg.C, adding skin conditioner, anti-allergy agent and antioxidant, stirring at 75 deg.C, cooling to 65 deg.C, and freezing to obtain ointment.
Note:
the camellia seed oil, lithospermum oil, olive oil and peppermint oil in tables 1 and 2 were prepared by the following methods:
and (3) camellia seed oil: selecting camellia trees planted in north latitude 25 degrees of south ridge (the latitude is abundant in sunlight, the soil is weakly acidic and is rich in various minerals and trace elements), picking fruits, piling up and retting, sun-drying the fruits, shelling and forming embryos, cold pressing, separating and filtering, crystallizing and filtering at low temperature, and producing oil;
lithospermum oil: pulverizing lithospermum to prepare lithospermum particles with the particle size of 0.5-2 mm, mixing the lithospermum particles and camellia seed oil according to a ratio of 1;
olive fruit oil: cold pressing olive fruits, filtering and discharging oil;
peppermint oil: selecting fresh stems and leaves of herba Menthae, and steam distilling.
And (3) performance testing:
1) Subjective efficacy testing:
100 infants with mild and moderate diaper rash (flush skin on the hip skin, chestnut-like skin rash, skin damage wave and 2-3 cm around anus, and basically consistent skin rash phenomenon) in 0-3 years old are selected and randomly divided into 10 groups, the infant soothing cream of the examples 1-3 and the infant soothing cream of the comparative examples 1-7 are respectively used, the using effect is tested, and the evaluation result is shown in the following table:
TABLE 3 subjective efficacy test results for infant buttocks
Note:
relieving itching: subjective evaluation was performed based on infant response.
As can be seen from Table 3: after the infant soothing cream disclosed by the invention is used for infants with mild and moderate diaper rash, the flushing of the hip skin is relieved, the red rash is reduced and weakened, the pruritus is relieved, and no adverse reaction occurs.
2) Human skin closed patch test:
the test method is based on: technical Specifications for cosmetic safety (2015 edition).
Selecting 32 volunteers of 18-30 years old who meet the test requirements, selecting a proper spot test device, adding a tested substance and a blank control (no substance is placed) into the spot test device by a closed spot test method, sticking the spot test device added with the tested substance on the inner side of the forearm of a testee, lightly pressing with a palm to uniformly stick the spot test device on the skin for 24 hours, observing skin reactions for 0.5 hour (after the indentation disappears), 24 hours and 48 hours after the spot test device of the tested substance is removed, and recording the observation results, wherein the test results are shown in the following table:
TABLE 4 test results of human skin blocking patch test
Note:
the skin response score was as follows:
0: negative reaction;
1: and (3) suspicious reaction: only faint erythema;
2: weak positive reaction (erythema reaction): erythema, infiltration, edema, and possibly pimples;
3: strong positive reaction (herpes reaction): erythema, infiltration, edema, pimples, herpes: the reaction goes beyond the test area;
4: very strong positive reaction (fusogenic herpes reaction): obvious erythema, severe infiltration, edema, fusional herpes: the reaction goes beyond the test area.
As can be seen from Table 4: after the test substance spot tester is removed, the rating grades of all volunteers are 0 at 0.5h, 24h and 48h, no adverse reaction occurs, and the infant soothing cream is safe and non-irritant.
3) Experimental test for antipruritic (preparation of guinea pig model of pruritus induced by histamine phosphate):
the utilization of histamine receptors is a class of G protein-coupled receptors that leads to a mechanism of pruritus by activating transient receptor potentials, which in turn activate a series of intracellular signaling. An allergic pruritus model is prepared by adopting a histamine phosphate-induced pruritus method, 40 guinea pigs are taken, the right and back instep are shaved 1 day before the experiment, and the hair removal area is about 2cm 2 The guinea pigs were randomly divided into 4 groups and depilated at 0.1g/cm for 2 consecutive days 2 The dosage of the composition is respectively and uniformly coatedThe infant soothing cream of examples 1 to 3 and comparative example 7, wherein the model control group was applied with an equal volume of physiological saline, and on day 3 of the experiment, an appropriate amount of histamine phosphate was weighed and prepared with a gradient concentration of 0.01% (w/v), 0.02% (w/v), 0.03% (w/v), 0.04% (w/v), 0.05% (w/v), 0.06% (w/v), 0.07% (w/v), 0.08% (w/v), 0.09% (w/v) and 0.10% (w/v) with physiological saline just before use, and the right and rear dorsum of the foot of the guinea pig was bruised with coarse sandpaper to have an area of about 1cm 2 After the sample is locally reapplied for 1 time, 0.05mL of 0.01% (w/v) phosphate group is dripped on the abraded part after 10min, whether the action of back foot of the guinea pig after back head licking appears within 3min is observed, if the action does not appear, 0.02% (w/v) histamine phosphate is dripped on the abraded part continuously, whether the action of foot adding appears within 3min is observed, the concentration is increased according to the gradient, 0.05mL of histamine phosphate solution is dripped on the abraded part every 3min until the action of back foot of the guinea pig after back head licking appears, the accumulated total amount of the histamine phosphate dripped at the moment is taken as the itch threshold, the itch threshold of each group is calculated, the difference of the index among the groups is compared, and the test data of the itch relieving experiment are shown in the following table:
TABLE 5 antipruritic Experimental test data
From table 5 it can be seen that: the infant soothing cream of examples 1-3 had better antipruritic effect than the infant soothing cream of comparative example 7, and the infant soothing cream of example 3 had much better antipruritic effect than the infant soothing cream of comparative example 7, with significant difference (P < 0.05), with statistical significance of the difference. Therefore, compared with a control sample, the infant soothing cream has a certain instant itching relieving and soothing effect, histamine medium is released during mosquito bite, the experiment is a simulated antihistaminic experiment, and the test result shows that the infant soothing cream has a good inhibition effect on pruritus caused by histamine stimulation.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (4)
1. An infant soothing cream, which is characterized in that: the composite material comprises the following components in percentage by mass:
thickening and stabilizing agent: 10 to 25 percent;
skin conditioner: 0.06 percent to 0.5 percent;
anti-allergic agent: 0.1 to 1 percent;
antioxidant: 0.1 to 1 percent;
and (3) an emollient: the balance;
the thickening stabilizer is prepared from beeswax, candelilla wax and hydrogenated olive oil according to the mass ratio of (5-15): (3-9): (2-6);
the skin conditioner is prepared from bisabolol and paeonol according to the mass ratio of (5-50): (1-5);
the anti-allergic agent consists of oat alkaloid, ascorbyl palmitate, 1, 2-pentanediol and 1, 2-butanediol;
the emollient is prepared from camellia seed oil, lithospermum oil, olive fruit oil and peppermint oil according to the mass ratio (33-39): (12-20):
(27-29): (0.2-2);
the camellia seed oil is prepared by cold pressing camellia seeds;
the lithospermum oil is prepared by soaking lithospermum in camellia seed oil;
the olive fruit oil is prepared by cold pressing olive fruits;
the oleum Menthae Dementholatum is prepared from stems and leaves of herba Menthae by steam distillation.
2. An infant soothing cream as claimed in claim 1 wherein: the antioxidant is tocopherol.
3. A process for preparing an infant soothing cream according to claim 1 or 2, characterized in that: the method comprises the following steps: heating and stirring thickening stabilizer, adding emollient, heating and stirring, adding skin conditioner, anti-allergy agent and antioxidant, heating and stirring, cooling, and freezing to obtain ointment.
4. The production method according to claim 3, characterized in that: the heating and stirring temperature is 75-85 ℃.
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| CN112716833A (en) * | 2021-01-15 | 2021-04-30 | 铂臻(广州)生物科技有限公司 | Mild nipple cream and preparation method thereof |
| CN113230169A (en) * | 2021-05-18 | 2021-08-10 | 扬州中汇生物技术有限公司 | Infant skin benefiting cream containing chiral supermolecule hydrogel and preparation method thereof |
| CN116098839B (en) * | 2023-04-11 | 2023-07-07 | 广州品赫化妆品有限公司 | Oil-soluble composition with relieving itching function and preparation method thereof |
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| JP2005002013A (en) * | 2003-06-10 | 2005-01-06 | Nippon Daily Health Kk | Cosmetic composition |
| JP2009013128A (en) * | 2007-07-06 | 2009-01-22 | Sosin:Kk | Skin care preparation for external use and oral composition |
| US20160375076A1 (en) * | 2015-06-29 | 2016-12-29 | Sirbal Ltd. | Herbal Combinations for Treating Eczema |
| CN104188885B (en) * | 2014-09-12 | 2018-04-03 | 皖南医学院 | A kind of moist humidity-preserving type Asian puccoon lip gloss and preparation method thereof |
| AU2016272282A1 (en) * | 2015-05-29 | 2018-01-25 | Igisu Co., Ltd. | Cyclic peptide, and medicine, external preparation and cosmetic each containing said cyclic peptide |
| CN111246888A (en) * | 2017-10-20 | 2020-06-05 | 日本乐敦制药株式会社 | Composition for ameliorating skin disorder |
| CN108498378A (en) * | 2018-04-19 | 2018-09-07 | 厦门千鹰生物科技有限公司 | A kind of mosquito repellent, antipruritic, detumescence compound plant essential oil and its application |
| CN108815022A (en) * | 2018-07-16 | 2018-11-16 | 卢雪 | A kind of flowers and plants oil and preparation method thereof |
| CN110237014A (en) * | 2019-07-04 | 2019-09-17 | 上海绿瑞生物科技有限公司 | A kind of water oil dual phase composition and preparation method thereof with the effect of releiving |
| CN110302121B (en) * | 2019-08-16 | 2022-04-26 | 澳思美日用化工（广州）有限公司 | Infant hip-protecting cream containing plant essence and preparation method thereof |
| CN110478413A (en) * | 2019-09-26 | 2019-11-22 | 广州艾蓓生物科技有限公司 | Antipruritic stick of a kind of camellia oil reparation and preparation method thereof |
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Address after: Unit 1201-1203, room 1201, building 1, No. 710, Zhongyuan Road, Suzhou Industrial Park, China (Jiangsu) pilot Free Trade Zone, Suzhou, Jiangsu 215000 Applicant after: Changzheng medical (Suzhou) Co.,Ltd. Address before: Room 2433, 847 Yan'an Middle Road, Jing'an District, Shanghai Applicant before: Shanghai NeWin Baby Products Co.,Ltd. |
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