CN112569163B - Anti-allergy repair emulsion without preservative and preparation method thereof - Google Patents

Abstract

The invention discloses an anti-allergy repair emulsion without preservative and a preparation method thereof, aiming at providing an emulsion which can improve the tolerance of skin, enhance the barrier function of skin and repair the damaged skin with anti-allergy; the technical scheme comprises the following components in parts by weight: 5-15 parts of polyhydric alcohol, 0.1-0.4 part of thickening agent, 0.01-0.1 part of chelating agent, 0.1-0.5 part of sodium hyaluronate, 0.1-0.3 part of sodium polyglutamate, 2-6 parts of soothing and anti-allergic factor, 1.1-2.8 parts of inhibitory stimulation factor, 1-4 parts of barrier repair factor, 2-4 parts of emulsion stabilizer, 15-20 parts of emollient, 0.2-0.5 part of aminomethyl propanol, 0.2-0.4 part of p-hydroxyacetophenone, 0.3-0.7 part of caprylyl hydroximic acid and the balance of water; belongs to the technical field of cosmetics.

Description

Anti-allergy repair emulsion without preservative and preparation method thereof

Technical Field

The invention discloses an emulsion, in particular to an emulsion with an anti-allergy repairing function, and also discloses a preparation method of the emulsion, belonging to the technical field of cosmetics.

Background

Skin constitution is the defense and adaptability of skin to external stimuli (small particles in the air, such as pollen, dust, and the like, environment, skin care products, climate change, and the like). Generally, good skin constitution can protect the skin from external stimuli and maintain the healthy state of the skin. In the case of sensitive skin, when external stimuli attack the skin, keratinocytes and mast cells release various inflammatory mediators, causing burning, stinging and tightening of the skin, etc., and accompanying itching, thereby causing redness, erythema, and sensitivity of the skin. Proper defense can inhibit the release of various inflammation mediums and weaken the discomfort of burning, stabbing pain and the like of the skin.

Sensitive muscle is a newly developed term for skin symptoms, is the most common skin discomfort symptom at present, and seriously influences the life quality of people. The term is used to describe the skin of an individual who is thought to have symptoms of facial hyperreactivity, which is believed to be more responsive to the external environment or to facial products than normal. Sensitive muscle is a physiological symptom, not a disease.

The skin symptoms of the sensitive muscle population are generally manifested by facial tightness, prickling, tingling and itching, burning sensation, pain, persistent itching and the like in the sense of sensation. The visual symptoms of the skin are erythema and skin flushing symptoms.

According to incomplete statistics, the current global sensitive skin population is close to 50 percent, and the population which thinks that the skin allergy symptoms of different degrees appear per se reaches more than 80 percent. The factors causing skin sensitivity are various and are roughly expressed as follows: environmental changes, exposure to chemosensitizers, daily over-cleaning, excessive stress on life and work, and irregular life. Stay up all night, irregular diet, etc. Due to the fact that factors causing skin sensitivity are various, and sensitive symptoms are different from person to person, the problem of skin sensitivity is solved, the comfort level of skin is improved, the market demands need to be closely combined, the reasons causing skin sensitivity are known from the source, the solution for sensitive skin is comprehensively considered, allergy prevention is needed on one hand, and the repair of damaged skin accompanied with sensitive skin symptoms is needed on the other hand.

In recent years, products sensitive to skin only stay at the concept declaration level, the sensitive symptoms of the skin cannot be really solved from the source, and the used anti-sensitive functional raw materials are only the accumulation of various raw materials and do not have corresponding data support data. Data in the aspects of in vitro and crowd test and the like cannot be found, so that the corresponding effect cannot be achieved aiming at the problem of skin sensitivity. On the contrary, in the screening process of raw materials, part of cosmetics with anti-allergy repair efficacy do not start from the skin constitution of sensitive skin, excessively pursue the effects of 'instant' and 'high efficiency', and a large amount of chemical preparations and hormone substances are selectively added, so that the raw materials do not generate skin dependence much, the sensitive and uncomfortable symptoms of the skin can be aggravated, the phenomena of skin pores, pimples, red spots, skin darkness, acne and the like are aggravated, the skin damage condition is more and more serious, and the skin tolerance can be damaged to a great extent; however, drugs for sensitive skin generally have various side effects and certain drug dependence, so that skin defense of people with sensitive skin is increasingly poor, and barrier damage is increasingly serious.

Disclosure of Invention

In view of the above problems, a first object of the present invention is to provide an anti-allergy repair emulsion containing no preservative, which contains no preservative, no pigment or essence, is natural, safe and non-irritant in raw material source, and a soothing anti-allergy factor composition is added to reduce discomfort symptoms of skin such as redness, swelling, itching and pricking, and a barrier repair factor is added to improve the problem of barrier damage of skin and improve the tolerance of skin, so that the emulsion achieves the effects of moisturizing skin, soothing existing sensitive symptoms, repairing skin barrier and improving skin tolerance.

The second purpose of the invention is to provide a preparation method of the anti-allergy repair emulsion, which has the advantages of simple operation, easy realization, convenient control of the process, higher production efficiency, less energy consumption, lower cost in the existing anti-allergy repair efficacy formula and realization of large-scale industrial production.

To this end, the invention provides for a first object to be such that:

an anti-allergy repair emulsion without preservative comprises the following raw materials in parts by weight: 5-15 parts of polyalcohol, 0.1-0.4 part of thickening agent, 0.01-0.1 part of chelating agent, 0.1-0.5 part of sodium hyaluronate, 0.1-0.3 part of sodium polyglutamate, 10-15 parts of soothing and anti-allergic factor, 1.1-2.8 parts of irritation inhibiting factor, 1-4 parts of barrier repair factor, 2-4 parts of emulsion stabilizer, 15-20 parts of emollient, 0.3-0.5 part of aminomethyl propanol, 0.2-0.4 part of p-hydroxyacetophenone, 0.3-0.7 part of caprylyl hydroximic acid and the balance of water.

Further, in the antiseptic-free anti-allergy repair emulsion, the polyhydric alcohol is at least two of glycerol, butanediol, pentanediol, hexanediol and propylene glycol.

Further, in the above antiseptic-free anti-allergy repair emulsion, the thickener is at least two of carbomer, xanthan gum, cetostearyl alcohol and behenyl alcohol.

Further, in the anti-allergy repair emulsion without the preservative, the chelating agent is EDTA-2Na.

Further, in the anti-allergy repair emulsion without preservative, the soothing and anti-allergy factors comprise astragalus membranaceus extract, aloe barbadensis extract, sophora flavescens extract, calendula extract, divaricate saposhnikovia root extract, gastrodia elata extract, albizia julibrissin flower extract and scutellaria baicalensis extract according to a mass ratio of 1-3:0.5-1:0.6-1:2-3:1.5-2:0.5-1:1-3: 0.6-1.2.

Furthermore, the anti-allergy repair emulsion without the preservative comprises the stimulation inhibition factors of kava extract, cactus extract and cassava starch according to the mass ratio of 0.1-0.8:0.5-1:0.5-1 by weight.

Further, in the antiseptic-free anti-allergy repair emulsion, the barrier repair factor is prepared from ceramide 1, ceramide 3, ceramide 6, natural VE, bisabolol, phytosterol, fatty acid and selaginella tamariscina extract according to a mass ratio of 0.5-1:0.5-1:0.5-1:0.2-0.5:0.5-1:0.5-1:0.5-1:1-1.5 by mixing.

Further, in the preservative-free anti-allergy repair emulsion, the emulsion stabilizer is at least three of hydrogenated lecithin, sorbitan olivate, cetearyl glucoside and polyglycerol-3 methyl glucose distearate.

Further, the above antiseptic-free anti-allergy repair emulsion has the emollient being a composition of shea butter, squalane, jojoba oil, isononyl isononanoate, ethylhexyl palmitate, caprylic capric triglyceride.

The second technical scheme provided by the invention is as follows:

the preparation method of the anti-allergy repair emulsion without the preservative sequentially comprises the following steps:

1) Weighing various components;

2) Adding the polyol, the chelating agent, the sodium hyaluronate, the thickening agent, the sodium polyglutamate and the p-hydroxyacetophenone weighed in the step 1) into the balance of water, stirring, dissolving and heating to 75-85 ℃, and continuously stirring for 10-15min until the mixture is completely dissolved to obtain a water phase;

3) Adding the emulsion stabilizer weighed in the step 1) into an emollient, stirring, dissolving and heating to 75-80 ℃, and continuously stirring for 5-8min until the emulsion stabilizer is completely dissolved to obtain an oil phase;

4) Adding the oil phase in the step 3) into the water phase in the step 2), stirring uniformly, homogenizing for 3-5min to form a uniform and stable emulsion, keeping the temperature, stirring for 10-15min, and cooling;

5) Cooling to 45-50 deg.C, sequentially adding aminomethyl propanol, octanoyl hydroximic acid, soothing anti-allergy factor, irritation inhibiting factor, and barrier repair factor, stirring, cooling to below 40 deg.C, and discharging to obtain anti-allergy repair emulsion.

Compared with the prior art, the technical scheme provided by the invention has the following technical advantages:

1. the soothing and anti-allergy factor used in the technical scheme provided by the invention has mild properties of raw materials, is extremely high in safety, does not bring discomfort to a human body, can effectively improve the soothing and anti-allergy effects of the anti-allergy repair emulsion, and relieves adverse irritation reactions to skin caused by external illumination, environmental pollution and the like: the astragalus membranaceus extract has a wide regulating effect on an immune system of an organism, can enhance the activity of macrophages, promotes the generation of cytokines and promotes the enhancement of T lymphocytes, so that the immune defense function of skin is comprehensively improved, and the effect of resisting external adverse stimulation of the skin body is increased; the aloe vera can eliminate skin inflammation, moisturize the skin, resist the sensitive symptoms of the skin and achieve the good effect of repairing the damaged skin; the sophora flavescens can be used as an antibacterial bacteriostatic agent and an anti-inflammatory agent, and can effectively relieve the existing inflammation of skin and reduce the inflammatory reaction of the skin; the calendula extract can eliminate skin inflammation, inhibit bacteria and resist bacteria; the divaricate saposhnikovia root and the tall gastrodia tuber can inhibit delayed hypersensitive reaction caused by dinitrochlorobenzene, and can achieve the effects of anti-inflammation and anti-allergy. Albizzin and tannin contained in the albizzia julibrissin can play a good role in tranquilizing and allaying excitement; the skin pores can be shrunk, and the problem of large pores is solved; the radix scutellariae extract contains baicalin and radix scutellariae, has wide antibacterial effect, can inhibit harmful bacteria such as staphylococcus aureus, hemolytic streptococcus and the like, has good effect of inhibiting skin problems caused by acne, also has a certain preservative effect, and can reduce the addition amount of preservatives in cosmetics; the baicalin can remarkably antagonize itching and allergic symptoms caused by histamine, prevent the release of an allergic reaction medium, inhibit the activity of hyaluronidase and have high-efficiency antiallergic effect; in summary, the idea of 'integration, syndrome differentiation and integration' of the relieving and anti-allergy factor provided by the invention is to analyze the mechanism of allergy generation, and carefully combine herbs such as astragalus membranaceus, divaricate saposhnikovia root, gastrodia elata, calendula, albizia flower and the like according to the formula principle of 'monarch, minister, assistant and guide' to form the cosmetic plant functional raw materials with anti-allergy effect. Experiments respectively adopt a phosphoric acid-induced itch domain method, a passive skin reaction method, a guinea pig skin dehydration model, human body evaluation and the like to research excellent soothing and allergy-relieving effects on soothing, itching relieving, redness dispelling, swelling diminishing, post-allergy repairing and skin soothing. Can be used for preventing and reducing irritation and sensitivity caused by common irritants in cosmetic formula. At the same time, the cell membrane can be repaired and protected to a certain extent, and DNA damage can be inhibited

2. The technical scheme provided by the invention is that the stimulation inhibition factor contains a kava extract, a cactus extract and cassava starch, the kava extract contains a plurality of kavalactones, and compared with single kavalactones, the compound kavalactones have a synergistic effect, have higher activity, and have the effects of sterilizing and eliminating harmful bacteria on skin; the compound cactus extract and the cassava powder extract can comprehensively prevent and reduce the stimulation and sensitivity phenomena caused by common stimulators in the formula of cosmetics by repairing cell membrane damage and DNA damage caused by stimulation.

3. The technical scheme provided by the invention is that the barrier repair factor contains ceramide 1, ceramide 3, ceramide 6, bisabolol, natural VE, phytosterol, fatty acid and selaginella tamariscina extract; wherein, ceramide 1, ceramide 3, ceramide 6, fatty acid and phytosterol form a main brick wall structure of the skin, and a lipid barrier is formed, so that excessive water loss caused by dryness, sensitivity and aging can be effectively resisted; the selaginella tamariscina extract acts on a cell activator, can obviously activate the activity of filaggrin, promote water to stay in a horny layer, effectively reduce the photoaging effect of skin, and induce the synthesis of two growth factors, so that the proliferation of dermal cells is caused, the activity of the cells can be increased, and the effect of improving the skin barrier is achieved; the natural tocopherol comprises a naturally-occurring alpha, beta, gamma and delta tocopherol mixture, can protect a finished product from being oxidized to a certain extent, prolong the shelf life of the product, repair skin to a certain extent, increase the luster and the moistening feeling of the skin, and can protect and care allergic skin by combining with the bisabolol, and researches also show that the bisabolol has a good antibacterial effect; can improve the discomfort symptoms of skin such as red swelling, erythema, pruritus and the like by reducing the release of inflammatory factors. Can be used for preventing and inhibiting inflammation.

4. According to the scheme provided by the invention, no preservative is added, so that the irritation of the preservative to skin is avoided, the overall safety and mildness of the formula are improved, and the irritation of the preservative to skin is cut off due to no preservative added in the formula. In addition, the formula is added with a combination of a soothing anti-allergy factor and a barrier repair factor. Firstly, the plant extract functional raw materials are introduced to inhibit the stimulation factors, and the discomfort possibly brought to the skin by the cosmetic raw materials/external stimulation and the like is relieved. Secondly, functional raw materials are introduced to relieve anti-allergy factors and relieve allergic symptoms. Thirdly, the introduced functional raw materials and barrier repair factors can improve the tolerance of the skin, and on one hand, the excessive reaction of the skin is reduced; on the other hand, the barrier function of the skin is enhanced, and the damaged skin is repaired; has excellent mild safety and is suitable for people with any skin constitution.

5. The anti-allergy repair emulsion prepared by the technical scheme provided by the invention has safe and harmless raw material sources. Conventional preservatives (phenoxyethanol, methylparaben and the like) are not added in the formula, and the purposes of preventing corrosion and prolonging the shelf life stability are achieved by adding p-hydroxyacetophenone and caprylyl hydroximic acid. The addition ratio of the p-hydroxyacetophenone to the octanoyl hydroximic acid proves that the composition has a better effect of preventing the breeding of microorganisms through the antiseptic challenge. In the design process of the formula, the addition amount of each raw material is strictly controlled, so that the matching degree of the used raw materials achieves a good effect, and the synergistic effect is realized. A large amount of plant source grease, jojoba oil, squalane, shea butter and sodium hyaluronate are used as main raw materials of the formula, and the effects of relieving skin, improving skin moistening degree, supplementing water and moisturizing and the like are achieved. The skin barrier effect is repaired on the basis of relieving the skin, the lipid structure required by the skin is supplemented, and the tolerance of the skin to resist external stimulation is improved.

6. The preparation process of the anti-allergy repair emulsion in the scheme provided by the invention is simple to operate and easy to control, has high production efficiency in actual production, and can realize large-scale production.

Drawings

FIG. 1 shows the inhibition of hyaluronidase results of example 2 versus the comparative experiment

FIG. 2 is a graph showing the effect of example 2 and comparative experiment 6 on the hemolysis rate of SDS-treated blood erythrocytes

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. For process parameters or conditions not specifically mentioned, it can be carried out with reference to conventional techniques.

Example 1

The invention provides an anti-allergy repair emulsion without preservative, and each 100g of the anti-allergy repair emulsion comprises the following raw materials in parts by weight: 3g of glycerin, 4g of butanediol, 0.2g of carbomer, 0.2g of xanthan gum, 0.01g of EDTA-2Na, 0.5g of sodium hyaluronate, 0.1g of sodium polyglutamate, 3g of bradykinin, 0.8g of kava extract, 1g of cactus extract, 1g of tapioca starch, 4g of barrier repair factor, 1g of hydrogenated lecithin, 1g of sorbitan olivate, 1g of cetearyl glucoside, 2g of shea butter, 2g of squalane, 2g of jojoba oil, 2g of isononyl isononanoate, 4g of ethylhexyl palmitate, 3g of caprylic capric triglyceride, 0.3g of aminomethyl propanol, 0.4g of p-hydroxyacetophenone, 0.3-0.7g of caprylyl hydroxamic acid, and the balance of water.

The soothing and anti-allergy factor is prepared from astragalus membranaceus extract, aloe barbadensis extract, sophora flavescens extract, calendula extract, radix sileris extract, gastrodia elata extract, albizia flower extract and scutellaria baicalensis extract according to a mass ratio of 3:0.5:1:2:2:0.5:3:0.6 by mixing.

The barrier repair factor is prepared from ceramide 1, ceramide 3, ceramide 6, natural VE, bisabolol, phytosterol, fatty acid and selaginella tamariscina extract according to the mass ratio of 1:0.5:0.5:0.5:0.5:0.8:0.7:1.3 are mixed.

Example 2

The invention provides an anti-allergy repair emulsion without preservative, wherein each 100g of the anti-allergy repair emulsion comprises the following raw materials in parts by weight: 2g of pentanediol, 2g of hexanediol, 1g of propylene glycol, 0.2g of xanthan gum, 0.1g of cetearyl alcohol, 0.01-0.1g of EDTA-2Na, 0.1-0.5g of sodium hyaluronate, 0.1-0.3g of sodium polyglutamate, 1-3g of soothing and anti-allergic factors, 0.1g of kava extract, 1g of cactus extract, 0.5g of tapioca starch, 1-4g of barrier repair factors, 0.5g of emulsion stabilizer hydrogenated lecithin, 0.5g of sorbitan olivate, 1g of cetearyl glucoside, 1g of hydrogenated lecithin, 1g of sorbitan olivate, 1g of cetearyl glucoside, 2g of shea butter, 2g of squalane, 3g of jojoba oil, 3g of isononyl isononanoate, 4g of ethylhexyl palmitate, 4g of caprylic capric triglyceride, 0.5g of aminomethyl propanol, 0.2-0.4 g of p-hydroxyacetophenone, 0.3-0.7g of caprylyl hydroximic acid, and the balance of water.

The soothing and anti-allergy factor is prepared from astragalus membranaceus extract, aloe barbadensis extract, sophora flavescens extract, calendula extract, radix sileris extract, gastrodia elata extract, albizia flower extract and scutellaria baicalensis extract according to a mass ratio of 2:0.8:0.6:2.5:1.5:1:1.2:1.2 and mixing.

The barrier repair factor is prepared from ceramide 1, ceramide 3, ceramide 6, natural VE, bisabolol, phytosterol, fatty acid and selaginella tamariscina extract according to the mass ratio of 0.5:0.8:0.8:0.2:0.7:1:1:1 by mixing.

Example 3

Every 100g of the anti-allergy repair emulsion without the preservative provided by the invention comprises the following raw materials in parts by weight: 10g of glycerol, 5g of hexanediol, 0.05g of cetearyl alcohol, 0.05g of behenyl alcohol, 0.01-0.1g of EDTA-2Na, 0.1-0.5g of sodium hyaluronate, 0.1-0.3g of sodium polyglutamate, 3g of brady anti-allergic factor, 0.5g of kava extract, 0.8g of cactus extract, 0.7g of tapioca starch, 1-4g of barrier repair factor, 1g of hydrogenated lecithin, 1g of sorbitan olivate, 1g of cetearyl glucoside, 1g of shea butter, 3g of squalane, 5g of jojoba oil, 2g of isononyl isononanoate, 3g of ethylhexyl palmitate, 4g of caprylic capric triglyceride, 0.4g of aminomethyl propanol, 0.2-0.4.4 of p-hydroxyacetophenone, 0.3-0.7g of caprylyl hydroxamic acid, and the balance of water.

The soothing and anti-allergy factor is prepared from astragalus membranaceus extract, aloe barbadensis extract, sophora flavescens extract, calendula extract, divaricate saposhnikovia root extract, gastrodia elata extract, albizia julibrissin flower extract and scutellaria baicalensis extract according to the mass ratio of 1:0.7:0.7:3:1.8:0.6:1:1.0 and mixing.

The barrier repair factor is prepared from ceramide 1, ceramide 3, ceramide 6, natural VE, bisabolol, phytosterol, fatty acid and selaginella tamariscina extract according to the mass ratio of 0.8:1:0.8:0.3:1:0.5:0.8:1.2 and mixing.

Example 4

The invention provides an anti-allergy repair emulsion without preservative, wherein each 100g of the anti-allergy repair emulsion comprises the following raw materials in parts by weight: 2g of glycerol, 2g of butanediol, 3g of pentanediol, 3g of hexanediol, 0.1g of carbomer, 0.1g of cetostearyl alcohol, 0.1g of behenyl alcohol, 0.01g to 0.1g of EDTA-2Na, 0.1g to 0.5g of sodium hyaluronate, 0.1g to 0.3g of sodium polyglutamate, 1g to 3g of brady anti-allergic factor, 0.3g of kava extract, 0.7g of cactus extract, 0.5g of tapioca starch, 1g to 4g of barrier repair factor, 1g of hydrogenated lecithin, 0.5g of sorbitan olivate, 1g of cetearyl glucoside, 3g of shea butter oil, 3g of squalane, 4g of jojoba oil, 3g of isononyl isononanoate, 4g of ethylhexyl palmitate, 3g of caprylic capric triglyceride, 0.3g of aminomethyl propanol, 0.2g of p-hydroxyacetophenone, 0.3g to 0.7g of caprylyl hydroxamic acid, and the balance of water.

The soothing and anti-allergy factor is prepared from astragalus membranaceus extract, aloe barbadensis extract, sophora flavescens extract, calendula extract, radix sileris extract, gastrodia elata extract, albizia flower extract and scutellaria baicalensis extract according to a mass ratio of 1.5:1:0.8:2.8:1.6:0.8:2:0.8 by mixing.

The barrier repair factor is prepared from ceramide 1, ceramide 3, ceramide 6, natural VE, bisabolol, phytosterol, fatty acid and selaginella tamariscina extract according to the mass ratio of 0.7:0.7:0.8:0.4:0.8:0.6:0.6:1.5 are mixed.

In order to better illustrate the advantages of the present application, the following experimental examples are given for the comparison of the technical solutions provided in the present application

Comparative experiment 1, in comparison to example 2, with the hydroxyacetophenone and the octanohydroxamic acid removed;

wherein comparative experiments 2-4, are to demonstrate the examples have an excellent skin feel experience,

comparative experiment 2, in comparison to example 2, shea butter was replaced with vaseline in equal amounts;

comparative experiment 3, compared to example 2, the hydrogenated lecithin was replaced with an equal amount of tween 20;

comparative experiment 4, compared to example 2, jojoba oil was replaced with an equal amount of hydrogenated polyisobutene;

comparative experiment 5 compared to example 2, the soothing anti-sensitivity factor was removed;

comparative experiment 6 compared to example 2, the inhibitory stimulus was removed;

comparative experiment 7 barrier repair factor was removed compared to example 2;

the emulsion preparation process in practice:

1) Weighing various components;

2) Adding the polyol, the chelating agent, the sodium hyaluronate, the thickening agent, the sodium polyglutamate and the p-hydroxyacetophenone weighed in the step 1) into the balance of water, stirring, dissolving and heating to 75-85 ℃, and continuously stirring for 10-15min until the mixture is completely dissolved to obtain a water phase;

3) Adding the emulsion stabilizer weighed in the step 1) into an emollient, stirring, dissolving and heating to 75-80 ℃, and continuously stirring for 5-8min until an oil phase is completely dissolved;

4) Adding the oil phase obtained in the step 3) into the water phase obtained in the step 2), uniformly stirring, homogenizing for 3-5min to form a uniform and stable emulsion, keeping the temperature, stirring for 10-15min, and cooling;

5) Cooling to 45-50 deg.C, sequentially adding aminomethyl propanol, caprylyl hydroximic acid, soothing anti-allergy factor, inhibitory stimulus factor, and barrier repair factor, stirring, cooling to below 40 deg.C, and discharging to obtain anti-allergy repair emulsion.

To prove the proof experiment of the preservative-free anti-allergy repair emulsion of the invention

1. Results of corrosion challenge test:

the preservative is not added in the formula, and the humectant is adopted to ensure the stability of the shelf life of the formula, so that the discomfort of allergy and the like caused by the introduction of the preservative to the skin is reduced, and the formula is ensured not to be excessively invaded by microorganisms in the shelf life. The humectant is added in an amount that passes the preservative challenge test and demonstrates a level of bacteria and mold within the cosmetic hygiene safety approved range over the relevant shelf life. Specific test results are shown in tables 1 and 2:

table 1 corrosion challenge test data results (bacteria)

TABLE 2 Corrosion protection challenge test data results (mold)

The result of preservative challenge shows that the addition of p-hydroxyacetophenone and caprylyl hydroxamic acid in example 2 can inhibit the generation of bacteria and mold in the anti-allergy repair emulsion to a certain extent, prevent the excessive amount of microorganisms in the product, and ensure the stability of the product in a long-term shelf life. In contrast, in comparative experiment 1, hydroxyacetophenone and caprylyl hydroximic acid are not added, so that the excess of bacteria and mold is shown, and a relevant corrosion prevention challenge experiment is not passed;

2 trial for people-skin feeling experience

The application of the invention carries out crowd trial aiming at the skin feeling experience of the product and collects related trial feedback results. Experiments examples 1,2,3 were carried out and comparative experiments 2,3,4 were carried out. In comparison experiments 2,3 and 4, on the premise of ensuring that the stability of the product passes, the used grease, emulsifier and the like are correspondingly adjusted. The experiment mainly screens indexes from the aspects of overall spreadability, absorptivity, moistening degree, greasy feeling and the like of the formula.

TABLE 3 sensory evaluation results of the anti-allergy repair emulsions of examples 1,2,3 and comparative experiments 2 to 4

The oil mainly used in the embodiment of the application is squalane, jojoba oil, shea butter oil and isononyl isononanoate, the emulsion stabilizer is a mixture of hydrogenated lecithin, sorbitan olivate and cetearyl glucoside, and the emulsifier and the oil are matched according to a certain proportion, so that the stability of the formula can be ensured, and meanwhile, the skin-feel experience of moistening, softness, easy absorption and smearing can be provided; in comparative experiments 2 to 4, compared to example 2, the unpleasant experiences such as slow absorption and poor spreadability were exhibited by replacing the oil or fat in the formulation or the emulsion stabilizer. The embodiment has good compatibility and can bring good skin-feel experience.

And an emulsion stabilizer is added into the anti-allergy repair emulsion to achieve the effect of long-term stability of the formula, and meanwhile, the sorbitan olivate and the cetearyl glucoside are used as combined emulsifiers and are plant sources, so that the anti-allergy repair emulsion is mild in property and high in safety. Simultaneously has good emulsification effect. In addition, the prepared anti-allergy repair emulsion has excellent stability, can well disperse oil used in the emulsion in a water phase, can keep long-term stability, has good texture and excellent spreadability in skin feel, and is quick to absorb. Hydrogenated lecithin is a natural emulsifier derived from soybean with anti-inflammatory activity, and is effective in reducing irritation and reducing potential irritation of other surfactants. The experimental result also shows that the anti-allergy repair emulsion prepared by adopting the hydrogenated lecithin as the emulsifier has excellent skin-sticking property and does not bring sticky and uncomfortable feeling;

3. efficacy verification test

The soothing anti-allergy factor, the irritation inhibiting factor and the barrier repair factor are added into the formula, so that the skin discomfort symptom is improved from the dimensionalities of improving skin sensitivity, reducing formula/environmental irritation, repairing damaged skin barrier and the like; the following experiments show the superiority of the present invention in terms of the amounts of inhibiting histamine release, reducing skin irritation, and reducing skin transdermal moisture loss value (TWEL), respectively;

(1) Experimental verification of relieving and anti-allergy efficacy

Mixing radix astragali, aloe Barbadensis, radix Sophorae Flavescentis, herba Sidae Rhombifoliae extract, radix Saposhnikoviae, rhizoma Gastrodiae, scutellariae radix extract, and herba Albiziae to obtain cosmetic with anti-allergy effect. Experiment the ability to inhibit histamine release was judged by determining the ability to alleviate and resist allergy in the examples and comparative experiments;

the ability to inhibit histamine release can be determined by inhibiting hyaluronidase. The higher the inhibition rate of hyaluronidase, the stronger its ability to inhibit histamine release. I.e., the stronger the soothing and anti-allergy effects. The experiment proves that the example has stronger capability of inhibiting the activity of the hyaluronidase compared with the comparative experiment, the effect is shown in figure 1, according to figure 1, the hyaluronidase inhibition rate in the example 2 reaches 70.7%, compared with the example 2, the comparative experiment 5 has the same components, and the hyaluronidase inhibition rate is only 6.56% after the soothing anti-sensitivity factor composition is removed, compared with the example 2. Namely, the examples have a good ability to inhibit histamine release, while the comparative experiment does not contain the bradykinin, which is very weak in its ability to inhibit histamine release. The experimental result shows that the soothing anti-allergic factor can obviously inhibit sensitive symptoms such as pruritus and the like caused by the release of histamine;

(2) Experimental verification of irritation inhibition efficacy

The irritation inhibiting factor comprises kava extract, cactus extract and tapioca starch. The stimulation factor can effectively inhibit the stimulation reaction caused by common sensitization sources (preservatives, essences, surfactants and the like). Comprehensively prevent and reduce the irritation and sensitivity caused by common irritants in cosmetic formulations.

In order to prove the inhibition effect of the inhibition stimulating factor on common stimulators, sodium Dodecyl Sulfate (SDS) is adopted as the stimulator of the surfactant in the experiment to stimulate the hemolysis of red blood cells, the hemolysis rate of the red blood cells is increased along with the increase of the addition amount of the surfactant, and the obvious hemolysis phenomenon of the red blood cells can occur when the addition amount of 0.4 percent of SDS is added;

experiment case 2 and comparative experiment 6 were carried out to treat the hemolyzed red blood cells, respectively, and the experimental results are shown in fig. 2, and it can be seen from fig. 2 that the hemolysis rate of the red blood cells treated with SDS reaches 100%, and the experiment was carried out using experiment case 2 and comparative experiment in order to demonstrate the inhibitory effect of the inhibitory stimulus factor on the stimulation caused by the surfactant. According to the experimental data, the hemolysis rate of the red blood cells of the inhibitory stimulating factor added in the embodiment is only 5.3 percent, and the inhibition rate reaches 94.7 percent; while comparative experiment 6, which is the comparative experiment of example 2 without addition of the inhibitory stimulating factor, has a hemolysis rate of 83.7% and an inhibitory rate of only 16.3% for erythrocytes. From the experimental results, it is found that the stimulation-inhibiting factor added in the present invention can significantly inhibit the stimulation caused by the surfactant.

(3) Experimental verification of barrier repair efficacy

The skin barrier repairing composition achieves the effect of repairing skin barriers by adding the composition of ceramide 1, ceramide 3, ceramide 6, natural VE, bisabolol, phytosterol, fatty acid, selaginella tamariscina extract and the like. The data show that topical lipid concentrates (ceramide 1, ceramide 3, ceramide 6, phytosterols, free fatty acids) can increase the natural lipid barrier of dry, sensitive and aged skin, relieving the skin's discomfort symptoms at the source. It can be used for preventing skin injury caused by water dispersion and external adverse factors. The lipid concentrate mimics the natural composition of a lipid barrier and is effective in remodeling the lipid barrier.

1. To verify the effect of the barrier repair factor on the skin barrier repair function, the results of the repair of the integrity of the skin barrier on the fifth day after SDS treatment were judged experimentally (based on the transdermal water loss value TWEL). The untreated and damaged skin has a good skin barrier function, the water content of the skin is recorded to be 100 at the moment, the moisture content of the damaged skin is 40, namely after the SDS treatment, the skin barrier damage is serious, and the skin moisture loss through skin is serious;

the formulation of example 2 with the barrier repair factor composition and the formulation of comparative experiment 7 without the barrier repair factor composition were obtained by treating the skin treated with SDS with the formulations of example 2 and comparative experiment 7, respectively, and observing the transdermal water loss value (TWEL), the results of which are shown in table 3:

table 4 skin barrier repair results are shown in the table below

As can be seen from the above table, the SDS-treated skin showed a significant percutaneous moisture loss value (TWEL). By adding the emulsion of the invention containing the barrier repair factor composition in example 2, the transdermal moisture loss value (TWEL) of the skin is obviously improved, and the moisture content of the skin is increased to 83 percent. In contrast, in comparative experiment 7, compared to example 2, the skin moisture content was not substantially improved by removing the barrier repair factor composition, i.e., comparative experiment 7 did not have the function of repairing the skin barrier. Namely, the barrier repair factor composition has a good value for reducing the skin moisture loss through skin. The barrier repair factor can well repair the barrier of the damaged skin.

4 safety test

(1) The test method briefly describes:

chorioallantoic membrane vascular test (CAMVA) method the potential ocular irritancy is assessed by observing the effect of the test substance on the blood vessels, taking 14-day-old chick embryos, the test substance being in direct contact with a small area of the CAM, and observing the CAM vascular changes, such as bleeding or hyperemia (telangiectasia), vascular obliteration (ghost vessels), after 30 minutes of exposure, the concentration of the test substance that causes 50% of the fertilized eggs to develop these lesions being considered the toxic endpoint. The CAMVA test requires the determination of the dose achieved by 50% positive reaction in 10 test chick embryos.

(2) And (4) result judgment standard:

TABLE 5CAMVA test Scoring standards

TABLE 6 evaluation criteria of skin care cosmetic irritation (CAMVA test) results

TABLE 7 test results of CAMVA test in example 2

Note: 1) The positive rate = the number of positive reaction chick embryos/the total chick embryos multiplied by 100%, and the positive reaction refers to the stimulation reaction with the score of 1-6 in the table;

2) Mean score = sum of 10 test chick embryo scores/10;

as can be seen from the above table, the positive rate of the camp test of example 2 of the anti-allergy repair emulsion of the present invention is 20%, and the average integral is 0.6; namely, the formula related by the application has good safety and mildness;

5 trial results of population- -verification of anti-allergy relieving efficacy

1 drop of the emulsion to be tested (1 pump) is respectively taken and smeared on the face and the arms of a test subject (18-45 years old, 60 samples), the irritation of the emulsion to the skin is tested, and after 30min, no obvious discomfort symptoms such as redness, pruritus and the like appear on the face and the arms. Thereby proving that the anti-allergy repair emulsion does not introduce irritation and increase the uncomfortable feeling of skin.

The test subjects were tested for a long period of 1 month, and the test population was a population with different degrees of facial redness, itching, tingling, and other symptoms. The test subject of the emulsion to be tested is smeared once in the morning and at night every day, and the test subject adopts the emulsion as a unique skin care product every day, so that the interference of other external factors is avoided. After 1 month, 81.67% of the subjects showed relief and disappearance of the symptoms of redness, itching, stinging. The smooth and greasy feeling of the skin is obviously improved. Test results show that the anti-allergy repair emulsion used in the invention application can show a good anti-allergy repair effect in crowd trial.

The results show that the average integral of the CAMVA test of the anti-allergy repair emulsion is 0.6, and the average integral is less than 1.64, so that the anti-allergy repair emulsion has safety and mildness and does not cause potential irritation or anaphylactic reaction to a human body. The crowd trial result reflects the anti-allergy repair emulsion, and the emulsion is verified again, so that a skin irritation sensitization source cannot be introduced, and on the other hand, the emulsion can relieve red, swelling, pruritus and stabbing pain symptoms of skin with the existing problems to a certain extent, can effectively improve symptoms of the skin with the problems, and has the effect of relieving and repairing. The compound use of ceramide and bisabolol in the application has good synergistic effect, and the improvement on skin is realized, so that the damaged barrier of skin can be improved, a good repairing effect is achieved, and the percutaneous moisture loss value of skin is reduced.

The anti-allergy repair emulsion has simple preparation method, and the process in the preparation process is easy to control and can easily achieve the expected effect. In addition, the whole preparation process is short in time consumption and high in production efficiency, the production cost is low in the existing emulsion with the anti-allergy effect, and large-scale production can be realized. In addition, by a process operation method, the adding sequence of the used raw materials and the mixing and stirring time and the stirring temperature are controlled, so that the anti-allergy repairing emulsion with excellent effects of allergy relief, irritation resistance, repairing and moisture preservation can be prepared. The jojoba oil, squalane, shea butter, sodium hyaluronate and the like in the formula can improve the moisturizing and moistening feeling of the anti-allergy repair emulsion, soften the skin, improve the permeability of the skin and increase the effect expression of the efficacy raw materials in the skin;

the raw materials used by the emulsion prepared by the invention are all safe and harmless substances, and all the raw materials show excellent safety and no irritation through chick embryo chorioallantoic membrane experiments, no preservative is added in the formula, and the emulsion is safe and harmless to the skin of a consumer, and in the design process of the formula, the raw materials can be ensured to achieve good matching effect and synergistic effect through strictly controlling the use amount of the raw materials, so that the maximum anti-allergy repair effect is achieved. The plant oil is adopted in the application as main raw materials for anti-allergy repair, and meanwhile, on the basis of relieving and anti-irritation, the relieving anti-allergy factors and the barrier repair factors are added to realize the effects of repairing, moisturizing and locking water on the skin, so that the prepared emulsion has the effects of better moisturizing and locking water, relieving and anti-irritation and repairing the skin barrier, and the mildness of the formula is ensured.

The emulsion prepared by the invention has the advantages of simple operation in the whole process, easy control of the process, good production efficiency, high anti-allergy effect and relatively low cost, and can realize large-scale industrial production.

The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such modifications are intended to be included in the scope of the present invention.

Claims (7)

1. An anti-allergy repair emulsion without preservative comprises the following raw materials in parts by weight: 5-15 parts of polyhydric alcohol, 0.1-0.4 part of thickening agent, 0.01-0.1 part of chelating agent, 0.1-0.5 part of sodium hyaluronate, 0.1-0.3 part of sodium polyglutamate, 2-6 parts of soothing and anti-allergic factor, 1.1-2.8 parts of inhibitory stimulation factor, 1-4 parts of barrier repair factor, 2-4 parts of emulsion stabilizer, 15-20 parts of emollient, 0.2-0.5 part of aminomethyl propanol, 0.2-0.4 part of p-hydroxyacetophenone, 0.3-0.7 part of caprylyl hydroximic acid and the balance of water;

the soothing and anti-allergy factor is prepared from astragalus membranaceus extract, aloe barbadensis extract, sophora flavescens extract, calendula extract, radix sileris extract, gastrodia elata extract, albizia flower extract and scutellaria baicalensis extract according to a mass ratio of 1-3:0.5-1:0.6-1:2-3:1.5-2:0.5-1:1-3: 0.6-1.2;

the stimulation-inhibiting factor is prepared from kava extract, cactus extract and cassava starch according to the mass ratio of 0.1-0.8:0.5-1:0.5-1 by weight;

the barrier repair factor is prepared from ceramide 1, ceramide 3, ceramide 6, natural VE, bisabolol, phytosterol, fatty acid and selaginella tamariscina extract according to the mass ratio of 0.5-1:0.5-1:0.5-1:0.2-0.5:0.5-1:0.5-1:0.5-1:1-1.5, and mixing.

2. The preservative-free, anti-sensitivity repairing emulsion according to claim 1, wherein said polyhydric alcohol is at least two of glycerin, butylene glycol, pentylene glycol, hexylene glycol, and propylene glycol.

3. The preservative-free anti-sensitization emulsion according to claim 1, wherein the thickener is at least two of carbomer, xanthan gum, cetearyl alcohol, and behenyl alcohol.

4. The preservative-free anti-sensitivity repair emulsion according to claim 1, wherein the chelating agent is EDTA-2Na.

5. The preservative-free anti-allergy restoration emulsion according to claim 1, wherein the emulsion stabilizer is a composition of hydrogenated lecithin, sorbitan olivate, cetearyl glucoside.

6. The preservative-free anti-sensitivity repair emulsion according to claim 1 wherein the emollient is a combination of shea butter, squalane, jojoba oil, isononyl isononanoate, ethylhexyl palmitate, caprylic capric triglyceride.

7. The method of preparing a preservative-free anti-sensitivity repair emulsion according to claim 1, comprising the following steps in sequence:

1) Weighing the components according to the parts by weight of the components in the claim 1;

2) Adding the polyol, the chelating agent, the sodium hyaluronate, the thickening agent, the sodium polyglutamate and the p-hydroxyacetophenone weighed in the step 1) into the balance of water, stirring, dissolving and heating to 75-85 ℃, and continuously stirring for 10-15min until the mixture is completely dissolved to obtain a water phase;

3) Adding the emulsion stabilizer weighed in the step 1) into an emollient, stirring, dissolving and heating to 75-80 ℃, and continuously stirring for 5-8min until the emulsion stabilizer is completely dissolved to obtain an oil phase;

4) Adding the oil phase in the step 3) into the water phase in the step 2), stirring uniformly, homogenizing for 3-5min to form a uniform and stable emulsion, keeping the temperature, stirring for 10-15min, and cooling;

5) Cooling to 45-50 deg.C, sequentially adding aminomethyl propanol, caprylyl hydroximic acid, soothing anti-allergy factor, inhibitory stimulus factor, and barrier repair factor, stirring, cooling to below 40 deg.C, and discharging to obtain anti-allergy repair emulsion.

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