KR20170103172A - Cosmetic compositions containing centella asiatica extract, ceramide and betula alba juice for relieving skin irritation and reinforcing skin barrier - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising a centilla mushroom extract, a ceramide and a birch sap, wherein the cosmetic composition of the present invention is a cosmetic composition comprising a core extract The effect is excellent.

Description

The present invention relates to cosmetic compositions containing centella asiatica extract, ceramide and betula alba juice for relieving skin irritation and reinforcing skin barrier,

The present invention relates to a cosmetic composition which alleviates skin irritation and improves skin barrier, and more particularly relates to a cosmetic composition containing a centilla sp. Extract, ceramide, and birch sap as an active ingredient.

The skin is divided into three layers of epidermis, dermis and subcutaneous adipose tissue in order from the outside, and functions to protect the human body from physical and chemical stimulation of the external environment. In particular, skin carries about 65 ~ 70% of the human body's moisture, that is, various physiologically active substances necessary for the human body, and plays an important role in regulating the evaporation of water to the outside of the body which helps the skin to maintain a smooth and moist condition . In addition, the epidermis is divided into the stratum corneum, granular layer, the superficial layer, and the basal layer in the order from the outside. The cells of the stratum corneum act as bricks, and the intercellular lipids between the keratinocytes act as the mortar, do. Skin barrier plays a role in controlling transepidermal water loss (TEWL) and drug delivery through the skin in the stratum corneum. The stratum corneum is composed of keratinocyte and keratocyte lipid. The keratocyte lipid is excreted through the extracellular flux over the boundary between the granule and stratum corneum and formed by keratinocytes present in granule layer. do.

When the normal keratinocyte moisture is maintained at about 10 to 30%, the skin is smooth and soft, and the body protection functions normally. However, when the moisture content of the keratinocyte layer is less than 10%, the skin becomes coarse, the protective function of the body is lost and the aging phenomenon occurs. In case of dry skin, the keratinocyte cohesion is weakened, Scaling phenomenon appears when skin is peeled off, because the moisture content of keratinocyte layer is smaller than normal skin.

In addition, even normal skin, due to various external factors such as cold weather, hot sunlight, dry air pollution, various stresses, and aging of skin due to age increase, It is important to keep the moisture content of the skin properly as it will become dry, rough and loose. Therefore, in order to maintain proper skin moisture, various studies have been made to supply water from the outside or to prevent water loss from the body, and various moisturizing agents having water retention ability have been developed. Examples of such moisturizing agents include hygroscopic wetting agents (e.g., urea or glycerin) or softening agents (e.g., oleyl alcohol or caprylic acid). In addition, some cosmetic gifts also use occlusive skin conditioners to provide a 'artificial barrier', which remains on the skin surface, including lipids, various waxes and butter. These ingredients generally do not constitute the natural component of the stratum corneum and can cause multiple skin side effects.

Accordingly, the present inventors have paid attention to ceramide having a function of lipid barrier which suppresses water evaporation and an ability to maintain a square structure of the stratum corneum, which is an important factor of skin barrier. In addition, It has been found that the skin barrier can be strengthened due to the characteristics of the raw material, and the moisturizing effect based on the maintenance of the moist skin due to the control of the moisturizing factor can be exhibited. Thus, the present invention has been completed.

As a related art, a cosmetic composition comprising a Centella asiatica extract as an active ingredient is disclosed in Patent Publication No. 10-2015-0045049, together with a Centella asiatica Liquid Extract, a Centella asiatica Liquid Extract, a Pine Needle Liquid Extract, A fermentation extract obtained after fermentation; And alkaline ionized water. In addition, Patent Registration No. 10-1239393 discloses a cosmetic composition comprising a centilla extract and various active ingredients. In addition, Patent Registration No. 10-0795512 discloses a skin protecting composition for antibacterial and skin moisturizing, which comprises a centimeter-seedling extract and a magnolia extract in a ratio of 1: 0.3 to 3.

On the other hand, as a prior patent relating to a cosmetic composition containing birch sap, patent No. 10-1106216 discloses a cosmetic composition comprising 100 parts by weight of a 30% by weight functional butylene glycol, 20 to 30 parts by weight of a herbal medicine mixed with ground powder,

A preventive cosmetic composition is disclosed. In addition, in Patent Registration No. 10-1584742, donkey oil; And a combination of donkey oil and sunflower seed oil in combination with argane tincture oil, lavender oil, olive oil, apricot seed oil, jojoba oil and sweet almond oil. A cosmetic composition for use as a cosmetic composition is disclosed.

The present invention has been accomplished by experimentally demonstrating that skin shampoo and skin barrier improvement effects are superior to cosmetic compositions using the above ingredients alone, by using a centilla, a centilla, and a birch sap extract together with birch sap .

Patent Publication No. 10-2015-0045049 Patent Registration No. 10-1239393 Patent Registration No. 10-0795512 Patent Registration No. 10-1106216 Patent Registration No. 10-1584742

It is an object of the present invention to provide a cosmetic composition which is superior in the effect of alleviating skin irritation and improving skin barrier compared to a cosmetic composition containing ceramides by further containing natural ingredients together with ceramides.

In particular, it is an object of the present invention to provide cosmetic compositions using natural ingredients such as centilla extracts and birch sap.

In particular, it is an object of the present invention to provide a cosmetic composition containing only a skin-trouble-free ingredient suitable for a cosmetic for children.

In order to achieve the above object, Ceramide; And birch sap as an active ingredient. The present invention also provides a cosmetic composition for skin irritation alleviation and skin barrier improvement effect.

Particularly, 0.001 to 70% by weight of centilla callus extract, 0.00005 to 30% by weight of ceramide, and 0.001 to 70% by weight of birch sap are preferred for the total weight of the cosmetic composition.

Particularly, the above-mentioned ceramide is preferably at least one selected from the group consisting of ceramide, ceramide, ceramide, ceramide, ceramide, and ceramide.

Particularly, the centilla extract is preferably an extract using ethanol as a solvent.

In particular, the cosmetic composition may further contain a carrier and / or an excipient.

In particular, the cosmetic composition may be in the form of any one of lotion, cream, oil, pack, mask, lotion, essence, powder, shampoo, rinse, foam cleanser, cleansing water, cleansing oil, cleansing lotion, cleansing cream, body cleanser and soap .

In the present invention, it was confirmed through experimentation that the use of the above three components together with the cosmetic composition of the comparative example using Ceramide, Centella asiatica, Birch sap, and Birch sap together improved skin irritation mitigation and skin barrier improvement. In particular, the cosmetic composition of the present invention is suitable as a cosmetic composition for children sensitive to skin irritation, because it contains ceramide, Centella asiatica extract, and birch sap as active ingredients.

The present invention provides a cosmetic composition for relieving skin irritation and improving skin barrier, which comprises a centilla sp. Extract, a ceramide, and a birch sap.

Hereinafter, each effective ingredient will be described in more detail.

Centipede extract

Centella Asiatica (Centella Asiatica) is a perennial plant belonging to the persimmon family. It originated in the eastern part of Africa and is now strong enough to be distributed in India, Sri Lanka, and Bengal Himalaya. The outposts of Asanaticoside, Madecassoside, Asiatic acid, and Madecassicacid are contained in the outposts of the centipedes. Especially, the main components of the centipedes are well known for their excellent collagen synthesis ability and effective for wound healing. The major components of the houseplants strengthen the skin, increase the antioxidant concentration at the wound site, and increase the blood supply to restore inflammatory tissue. It is effective enough to be used as an external medicine for burns, psoriasis, prevention of scarring after surgery, and hemorrhoids treatment.

The centilla extract may be produced by various methods, but an extraction method using an extraction solvent as described below may be preferable. For example, after washing the bedspread cleanly with water, it is dried in the shade. The dried cloves are placed in an extraction container, an appropriate amount of extraction solvent is added, and the mixture is extracted at a suitable temperature for a certain period of time. The extract can be filtered and concentrated using a vacuum rotary evaporator or the like. The extraction solvent may be a polar solvent selected from water (purified water), a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof, preferably ethanol. The amount of the extraction solvent is 5 to 10 times the dry weight of the herbal medicine. The extraction temperature is 40 to 90 캜, preferably 60 to 80 캜, and most preferably 70 캜, which is most effective in preventing decay, discoloration and detachment. The extraction time is 1 to 10 hours, preferably 3 hours. After obtaining the Centella asiatica extract, the solid matter is removed using a filter paper or the like, the suspension is centrifuged, and the supernatant can be filtrated under reduced pressure.

In the present invention, Centella asiatica extract has an effect of alleviating skin irritation and improving skin barrier as compared with ceramide alone. The centilla extract is preferably used in an amount of 0.001 to 70% by weight based on the total weight of the cosmetic composition of the present invention, but is not limited thereto. If the content is too low, the efficacy of Centella asiatica extract can not be seen, and if too much, the effect of other active ingredients is halved.

Ceramide

Ceramide is a major lipid component that constitutes the stratum corneum and plays an important role in the formation of moisturizing function and skin barrier diseases of the skin. Ceramide is a type of sphingoid lipid that is composed of sphingosine or phytosphingosine with fatty acids connected to it. It occupies about 40 ~ 50% of the intercellular lipids constituting the skin stratum corneum and is essential for the formation and function of the stratum corneum. It acts as a lipid barrier to inhibit water evaporation in the stratum corneum and maintains a square structure of the stratum corneum. Ceramides present in the human body are classified into six types depending on the degree of polarity. Acetamide I (ceramide 1), ceramide II, and ceramide II (ceramide II) have the lowest polarity and have the sphingosine as the skeleton. The ceramide myoin (ceramide 3) is a synthetic N-acetylated phytosphingosine to be. Because of their distinctive structure and physicochemical properties, ceramides play a role in forming optimal permeation barriers.

In the present invention, ceramides can be used by dissolving them in ethanol or a polar solution. The ceramide component is preferably contained in an amount of 0.00005 to 30% by weight based on the total weight of the cosmetic composition of the present invention, but the amount of the ceramide to be used is limited because it is expensive.

Birch sap

Birch is a deciduous broad-leaved tree belonging to the birch family. It grows up to 25 meters in height and 1m in diameter. The distribution area grows in Korea, Japan, China and so on. Birch has long been used as a medicinal product and has been known to be effective for nephritis, edema, gastritis and neuralgia. Birch sap has been collected in early spring and has been used in diabetes, appetite stimulation, nervous stability, gastrointestinal diseases in the private sector.

In the present invention, the birch sap was collected by filtering the filtered birch sap, then refrigerated. The birch sap of the present invention plays a role of enhancing the efficacy of ceramides in addition to the centilla callus extract. Preferably, the birch sap is used in an amount of 0.001 to 70% by weight based on the total weight of the cosmetic composition of the present invention. It is not. If the content is too low, the efficacy of birch sap is not visible, and if too much, the effect of other active ingredients is halved.

Formulations and others

The cosmetic composition of the present invention may be prepared by further adding conventional ingredients such as carriers, excipients, vitamins and other common ingredients such as ionized water and may be in the form of lotions, creams, oils, packs, masks, lotions, essences, powders, Foam cleanser, cleansing water, cleansing oil, cleansing lotion, cleansing cream, body cleanser and soap.

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester,

Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.

Hereinafter, the present invention will be described in detail with reference to Examples and Test Examples. However, the present invention is not limited by the following examples and experimental examples.

Example  1 and Comparative Example  1 to 3

The cosmetic compositions of Example 1 and Comparative Examples 1 to 3 were prepared in cream form having the composition ratios shown in the following Table 1. Example 1 is a cosmetic composition prepared according to the present invention, which contains both centipede extracts, ceramide, and birch sap. Comparative Example 1 is a comparative example comprising only Centella asiatica extract as an active ingredient, And Comparative Example 3 is a comparative example including only birch sap. The examples and comparative examples were further prepared by adding 100 wt% each of stearyl alcohol, wax, squalane, purified water and the like as additional components.

ingredient Content (% by weight) Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Centipede extract 2 4.5 - - Ceramide 0.5 - 0.5 - Birch sap 2 - - 4.5 Pro-type glycerin monostearate 2 2 2 2 Stearyl alcohol 2.2 2.2 2.2 2.2 Stearic acid 1.5 1.5 1.5 1.5 Wax One One One One Polysorbate 60 1.5 1.5 1.5 1.5 Sorbitan stearate 0.6 0.6 0.6 0.6 Purified vegetable oil One One One One Squalane 3 3 3 3 Mineral oil 5 5 5 5 Trioctanoin 5 5 5 5 Dimethicone One One One One Sodium magnesium silicate 0.1 0.1 0.1 0.1 glycerin 5 5 5 5 Betaine 3 3 3 3 Triethanolamine One One One One Sodium hyaruronate 4 4 4 4 Preservative, fragrance, pigment a very small amount a very small amount a very small amount a very small amount Purified water Balance Balance Balance Balance Sum 100 100 100 100

Experimental Example  1: Skin barrier improvement effect

In order to evaluate the skin barrier improvement effect of the composition of the present invention, 20 human subjects were subjected to human body application tests. The TEWL of the test area was measured using a trans-epidermal water loss meter. The inner part of the left lower limb was divided into 5 parts using 3M tape, and the tape was stripped 10-15 times (cream), the cream of Comparative Example 1, the cream of Comparative Example 2, and the cream of Comparative Example 3 were applied to the test piece, and a TEWL (trans -epidermal water loss, transdermal water loss) were measured to evaluate skin barrier improvement effect.

sample TEWL rate of change (%) Control (untreated) 58 Example 1 17 Comparative Example 1 29 Comparative Example 2 25 Comparative Example 3 32

As shown in Table 2, the amount of loss of transdermal water loss at the site where the cosmetic composition of the present invention was applied in Example 1 was higher than that of Comparative Example 1 (locust extract alone), 2 (ceramide alone), and 3 (birch sap alone) It was confirmed that the rate of change of TEWL was remarkably lower than that of the portion where the composition was applied. That is, it can be confirmed that the skin barrier improvement effect is enhanced when the centilla and the birch sap are simultaneously used as in the present invention, compared to the case where each component is used singly.

Experimental Example  2: Effect of skin irritation mitigation

In order to evaluate the skin irritation mitigating effect of the composition of the present invention, 20 human subjects were subjected to human body application tests. The forearm of the subject's arm was designated as the test site, and a 2% solution of SLS (sodium lauryl sulfate) was occlusive-patched on each test site for the test site at the first visit of the subject. On the second visit (day 0), the cream of Example 1, the cream of Comparative Example 1, the cream of Comparative Example 2, and the cream of Comparative Example 3 were applied after removing the patches, Were measured. During the test period of 14 days, the test site was not subjected to any rinsing, and the samples were used daily in the order specified on the sample site of the subject. Evaluation of skin irritation mitigation effect by skin erythema measurement using a Mexameter on a cream, a cream of Example 1, a cream of Comparative Example 2, a cream of Comparative Example 2, and a cream of Comparative Example 3 was evaluated Are shown in Table 3.

sample 14 days after application
Improvement rate of skin erythema (%) Control (untreated) 2.7% Example 1 9.8% Comparative Example 1 5.6% Comparative Example 2 5.2% Comparative Example 3 4.1%

As shown in Table 3, the skin erythema improvement rate of the area coated with the cosmetic composition of the present invention of Example 1 was higher than that of Comparative Example 1 (locust extract alone), 2 (ceramide alone), and 3 (birch sap alone) It was confirmed that the rate of improvement was relatively higher than that at the site where the cosmetic composition was applied. In other words, it was confirmed that when the centilla and the birch sap are simultaneously used as in the present invention, the skin irritation alleviating effect is obtained as compared with the case where the respective components are used singly.

Claims (6)

Centipede extract; Ceramide; And birch sap as an effective ingredient to reduce skin irritation and improve skin barrier.
The cosmetic composition according to claim 1, wherein the composition comprises 0.001 to 70% by weight of Centella asiatica extract, 0.00005 to 30% by weight of ceramide, and 0.001 to 70% by weight of Birch sap as a total weight of the cosmetic composition.
The cosmetic composition according to claim 1, wherein the ceramide is at least one selected from the group consisting of ceramide, ceramide, ceramide, ceramide, ceramide, and ceramide.
The cosmetic composition according to claim 1, wherein the centilla annulus extract is an extract using ethanol as a solvent, which is effective to alleviate skin irritation and improve skin barrier.
The cosmetic composition according to claim 1, wherein the cosmetic composition further comprises a carrier or an excipient.
The cosmetic composition according to claim 1, wherein the cosmetic composition is at least one of lotion, cream, oil, pack, mask, lotion, essence, powder, shampoo, rinse, foam cleanser, cleansing water, cleansing oil, cleansing lotion, cleansing cream, body cleanser and soap One form of the cosmetic composition has the effect of alleviating skin irritation and improving skin barrier.