KR100361040B1 - Skin care composition containing stabilized phellodendri radix, macrocarpium dfficinale, rheum coreanum, prunus ansu, angelica gigas, eugenia caryophyllata, imperata cylindrica with niosome - Google Patents

Abstract

The present invention is a herbal ingredient as baekbaek, cornus, rhubarb, almond, Angelica, cloves And The present invention relates to a cosmetic composition containing niobium stabilized strip extract, which is a herbaceous plant belonging to the sugar cane family, and the cosmetic composition of the present invention is sulfuric acid, cornus, rhubarb, almond, donkey, clove, which are the active ingredients of the present invention. And The extract of the strip is contained in an amount of 0.1 to 10% by weight based on the total weight of niosomes.

Specifically, a stable nonionic surfactant, coemulsifier, cholesterol, cholesteryl ester and soysterol are used to emulsify the high pressure emulsification to complete niosomes with a closed double layer structure, and the effective effect of the present invention in the closed double layer structure. By effectively stabilizing the extracts of the components of baekbaek, cornus, rhubarb, almonds, Angelica, cloves, and strips, it is possible to maximize the effect of the active ingredients, such as promoting skin elasticity, continuous moisturizing and skin penetration effect.

Description

Skin care composition containing stabilized phellodendri radix, macrocarpium dfficinale, rheum coreanum, prunus ansu, angelica gigas, eugenia caryophyllata, imperata cylindrica with niosome}

The present invention relates to a cosmetic composition containing niosomes stabilized herbal ingredients excellent in skin beauty and improvement effect.

People with healthy skin are active in skin cells, and the synthesis and metabolism of collagen, which plays an important role in inhibiting skin elasticity and wrinkle formation in fibroblasts in the dermis, is active. Hyaluronic acid is essential for maintaining skin moisture. Glycos aminoglycans (GAGS), which is a glycoprotein, including the active synthesis, gives skin elasticity, softness, flexibility and moisturizing. In addition, the epidermis is active in the proliferation of basal cells, and the production of binding proteins such as laminin, integrin, and desmosome, which enhance the binding between skin cells, is balanced, thereby strengthening skin tissue and maintaining healthy skin. However, the skin of modern man is exposed to various harmful environment and stresses and suffers various damages. As the skin ages, the skin's physiological activity decreases and the damaged skin's recovery rate slows down, the skin loses elasticity, dryness, wrinkle formation, and dull skin Various skin aging symptoms such as. Therefore, the biggest goal of cosmetics is to improve the aging symptoms, various cosmetics have been developed for this.

Niosomes to stabilize the active ingredient in the present invention is a special kind of liposomes that are currently used in drug delivery systems by stabilizing bioactive components in the pharmaceutical field. Liposomes are currently widely used in the pharmaceutical field as well as cosmetics, foods, etc., because they can deliver the bioactive ingredients in a stable manner without breaking, and have the advantage that they can contain both fat-soluble and water-soluble. Liposomes are largely divided into multi-layered liposomes (MLV) and monolithic liposomes (ULV), and ULVs can be divided into large-membrane liposomes (LUV) and small-membrane liposomes (SLV). MLVs are 400-3500 nm in size and can contain 5-15% of the liposomes, LUVs are 100-1000 nm and 36-65% of the amount can be encapsulated in liposomes. Is 20-50 nm and the amount which can be contained in liposome is 0.5-1.0%. The amount of bioactive substances that can be contained is the most LUV but unstable, SLV is the most stable but the amount that can contain less. In addition, since the human skin structure has a multi-layered structure, MLV has affinity with the skin but is too large to penetrate the skin.

Compared to these liposomes, niosomes have a size of 10 to 200 nm and are easy to penetrate the skin, and contain more water-soluble components than liposomes and are stable. In addition, the liposomes are formed by phospholipids, while niosomes form vesicles using sphingolipid derivatives such as ceramide, cerebromide, sphingomyelin, and bioactive components in the vesicles. Nested.

The present invention is to enhance the skin physiological activity of the skin degraded by age, stress, ultraviolet rays, environmental pollution, drying, etc. in order to enhance the skin beauty effect and skin improvement effect on the herbaceous plants belonging to the Korean herbal medicine and sugarcane family It is to develop excellent materials into cosmetics.

The present inventors further mix nibs, which are herbaceous plants that exhibit a continuous moisturizing effect, to the herbal composition of the present invention for protecting the skin from the external environment such as ultraviolet rays, environmental pollution and stress, irregular lifestyle, lack of exercise, and the like. The present invention has been completed by stabilizing.

The present invention, yellow white, cornus, rhubarb, almond, Angelica, cloves And The present invention relates to a cosmetic composition containing niosomes in which an extract of a band is stabilized.

Niosome-containing cosmetic composition of the present invention is 0.1 to 10% by weight of the extract of the herbaceous plants of the herbaceous plants belonging to the yellow, yellow, rhubarb, rhubarb, almond, clove and sugarcane, which are the active ingredients of the present invention It is preferable to contain in the quantity of, More preferably, it contains 0.5 to 5.0 weight%.

More specifically, yellow white, cornus, rhubarb, almond, Angelica, cloves in niosomes And Each of the extracts is preferably contained in an amount of 0.001 to 3.0% by weight, and more preferably 0.01 to 1.0% by weight, based on the total weight of niosomes.

The yellowish white of the present invention is the bark of the yellowish white, which is a plant of Unhyanghwa (Rutaceae), and its properties are cold, bitter and poisonous. It mainly eliminates the heat, jaundice, and devices gathered in the intestine and intestine. Diarrhea and dysentery, baekbhadae, heals the food window, kills the worms, scabies and ringworms, fever and soreness in the eyes, heals the sick, and the mouth is used to relieve fever and osseous fever. In addition, it contains flavonoids and alkaloids, so it is excellent in UV protection and antibacterial, anti-inflammatory and antiviral effects on the skin.

Cornus is the fruit of Cornus, a dogwood (Cornaceae) plant that is slightly warm in nature, tastes sour, and has no poison. Yin (陰) is vigorous, Shinjung (精) and Shin (腎氣) to see, improve sexual function, penis is enlarged and enlarged. It also helps cleanse (精髓) and warms the waist and knees, helping the gods (水 藏). It helps to urinate more often, to help older people to pee at times, and to soothe wind, nose, and deafness. In addition, it contains 15% or more of saponin, which has an excellent astringent effect and also has an effect of removing harmful oxygen, thereby improving skin.

Rhubarb is the root and stem of the upper leaf rhubarb, a plant of the Polygonaceae family. It is very cold, tastes bitter, and has no poison. The blood and menstrual blockage to go out and faeces well. Heals the warmth and fever and heals Onggi, Seng, and Jongpok. It is called general pool. In addition, it is excellent in UV blocking effect, harmful oxygen removal effect, antioxidant and antibacterial effect.

Pedestrians are mature seeds of the apricot, Rosaceae, whose nature is warm, sweet, bitter, and poisonous. Heals coughs, heals teeth, and discards breaths, and heals and bleeds (解肌) to sweat and detoxify dogs. In addition, it contains a large amount of unsaturated fatty acid, so it has excellent skin soothing and softening effect.

The donkey is the root of a true donkey, a plant of the Umbeliferae family. It is warm in nature, sweet in taste, very poisonous. Heals all wind sickness, blood clots, and frailty, and heals blood and produces blood. He is injured by various bad spears and iron, and heals the blood. The dysentery will make the stomach ache, protect the five intestines, and revive the flesh. It also has excellent skin soothing, anti-inflammatory and whitening effect

Clove is a volatile oil and fruit obtained by distilling the flowers or flowers of the clove, Myrtaceae, which is warm in nature, tastes spicy, and has no poison. The stomach warms up, Kwakran, Shingi (腎氣), shedding (奔豚 氣) and cold sore stomach ill and scrotum pain is better. It also improves sexual function, warms the waist and knees, relieves anti-country sickness, eliminates alcohol and poison, and heals various boils. It relieves sensation and gives various scents. In addition, the antioxidant effect and harmful oxygen removal effect is excellent.

The band is a perennial plant of Reed and the plant Poaful (stem is hollow and hollow, with nodes). It lives in mountains and wasteland and blooms in early summer with white or black purple flowers. It also inhabits the Korean peninsula, and in the provinces it is also called 'gigi'. It is a herbaceous plant belonging to the sugar cane family and provides potassium ions (K +), which play an important role in equilibrating the osmotic pressure in the skin.

The present invention uses a mixture of stable nonionic surfactants, co-emulsifiers, cholesterol, cholesteryl esters and soysterol to achieve niosomes with a closed bilayer structure, and to achieve the effectiveness of the present invention in this closed double layer structure. By effectively stabilizing the extracts of the components of baekbaek, cornus, rhubarb, almonds, Angelica, cloves and zodiac can maximize the effect of the active ingredient.

More specifically, nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene alkyl esters, saccharose diesters, etc., the amount of which is contained in an amount of 10 to 50% by weight based on the total weight of niosomes. It is preferable, More preferably, it contains 30 to 40 weight%.

Diglycerol is used as the auxiliary emulsifier, and the amount thereof is preferably contained in an amount of 1 to 50% by weight, more preferably 2 to 10% by weight, based on the total weight of niosomes.

Cholesterol, cholesteryl ester and soysterol are preferably contained in an amount of 30 to 80% by weight, more preferably 50 to 70% by weight, based on the total weight of niosomes, wherein the cholesteryl ester is cholesterol Rylnonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, cholesteryl isostearyl carbonate, and the like.

In addition, since only the nonionic surfactant can be expected to play a role of the lipid of the skin, it was made to be similar to the natural lipid component by binding the ceramide to the glycerin skeleton to have amphiphilic properties. The ceramide used at this time is preferably contained in an amount of 0.1 to 10% by weight, more preferably 2.0 to 6.0% by weight based on the total weight of niosomes.

The cosmetic composition of the present invention is not particularly limited in the formulation, for example, supple cosmetics, astringent cosmetics, nourishing cosmetics, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, essence And packs and the like formulations.

In addition, herbal compositions including yellow and white, cornus, rhubarb, almonds, cactus and clove and the herbaceous plants belonging to the sugar cane can be appropriately selected and blended by those skilled in the art without difficulty according to the formulation or use purpose of the cosmetics.

Hereinafter, one or more exemplary embodiments and experimental examples will be described in detail, but the present invention is not intended to be limited thereto.

Preparation Example 1 Yellow White Extract

After washing with purified water and drying, 1 kg of powdered sulfur white powder was added to 5 L of 70% ethanol aqueous solution, extracted for 3 to 5 days at 15 to 40 ° C., filtered through a 300 mesh filter cloth, and left at 4 to 15 ° C. for 7 to 10 days. After aging at low temperature, the filter was filtered using Whatman No. 2 filter paper. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 37.5 g (dry weight), and the extraction yield was 3.7 ± 0.5%.

Preparation Example 2 Cornus Extract

After washing with purified water and drying, 1 kg of powdered cornus oil powder was added to 5 L of 70% ethanol aqueous solution, extracted for 3 days in an extractor equipped with a cooling condenser, filtered through 300 mesh filter cloth, and left at 4 to 15 ° C. for 7 to 10 days. After aging, the filter was filtered using Whatman No. 2 filter paper. The extract was concentrated under reduced pressure to 70 ° C. in a distillation unit with a cooling condenser and dried to obtain 24.9 g (dry weight), and the extraction yield was 2.5 ± 0.4%.

Preparation Example 3 Rhubarb Extract

After washing with purified water and drying, 1 kg of powdered rhubarb powder was added to 5 L of 70% ethanol aqueous solution, extracted for 3 to 5 days at 15 to 40 ° C, filtered through a 300 mesh filter cloth, and left to stand at 4 to 15 ° C for 7 to 10 days. After aging at low temperature, the filter was filtered using Whatman No. 2 filter paper. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 61.1 g (dry weight), and the extraction yield was 6.1 ± 0.7%.

Preparation Example 4 Almond Extract

1 kg of powdered almond powder was added to 5 L of 70% ethanol aqueous solution, extracted for 3 to 5 days at 15 to 40 ° C., filtered through a 300 mesh filter cloth, and left to stand at 4 to 15 ° C. for 7 to 10 days. After aging at low temperature, the filter was filtered using Whatman No. 2 filter paper. The extract was concentrated under reduced pressure to 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 32.3 g (dry weight), and the extraction yield was 3.2 ± 0.5%.

Preparation Example 5 Angelica Extract

1 kg of powdered Angelica powder was added to 5 l of 70% ethanol aqueous solution, extracted for 3 to 5 days at 4 to 15 ° C, filtered through a 300 mesh filter cloth, and left at 4 to 15 ° C for 7 to 10 days. After aging at low temperature, the filter was filtered using Whatman No. 2 filter paper. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 54.7 g (dry weight), and the extraction yield was 5.5 ± 0.5%.

Preparation Example 6 Clove Extract

After washing with purified water and drying, 1 kg of powdered clove powder was added to 5 L of 70% ethanol aqueous solution, extracted for 3 to 5 days at 15 to 40 ° C, filtered through a 300 mesh filter cloth, and left to stand at 4 to 15 ° C for 7 to 10 days. After aging at low temperature, the filter was filtered using Whatman No. 2 filter paper. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 63.3 g (dry weight), and the extraction yield was 6.3 ± 0.7%.

Preparation Example 7 Band Extract

After washing with purified water and drying, 1 kg of powdered strip powder was placed in 5 L of 70% ethanol aqueous solution, extracted for 3 to 5 days at 4 to 15 ° C, filtered through a 300 mesh filter cloth, and left at 4 to 15 ° C for 7 to 10 days. After aging at low temperature, the filter was filtered using Whatman No. 2 filter paper. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 24.5 g (dry weight), and the extraction yield was 2.4 ± 0.5%.

Preparation Example 8 Method of Preparation

Niosomes are obtained by heating the A phase to 90 ° C. as a composition of the following table, mixing and dissolving it uniformly, cooling to 45 ° C., adding the B phase, and then passing it three times through a high pressure emulsifier under a pressure condition of 1000 bar.

Niosomes ingredient weight% A Polyoxyethylene alkyl ether 10.0 Saccharose diester 20.0 Polyoxyethylene alkyl ester 7.0 Diglycerol 4.0 cholesterol 25.0 Cholesteryl Nonanoate 10.0 Soysterol 15.0 Ceramide 7.0 B Yellow White Extract 0.5 Cornus Extract 0.5 Rhubarb extract 0.5 Almond extract 0.5 Angelica Extract 0.5 Clove Extract 0.5 Strip extract 0.5 system 100

The active ingredient of the present invention stabilized in the niosomes, sulfur white, cornus, rhubarb, almond, donkey, cloves and strip extracts are prepared in Preparation Examples 1-7.

Examples 1, 2, 3 and Comparative Examples 1, 2

According to the present invention, as shown in Table 2, a composition containing niosomes stabilized extracts of sulfur white, cornus, rhubarb, almonds, Angelica, cloves, and bands (example) and compositions containing no niosomes (comparative examples) Was prepared.

Unit: weight% ingredient Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Delta-tocopherol 0.3 0.3 0.3 0.3 0.3 0.3 Niosome 20.0 10.0 5.0 1.0 - - Yellow White Extract - - - - 2.0 - Cornus extract - - - - 2.0 - Rhubarb extract - - - - 2.0 - Almond Extract - - - - 2.0 - Angelica Extract - - - - 2.0 - Clove Extract - - - - 2.0 - Strip extract - - - - 2.0 - A Cetostearyl alcohol 2.0 2.0 2.0 2.0 2.0 2.0 Glyceryl Stearate 1.5 1.5 1.5 1.5 1.5 1.5 Microcrystalline Wax 0.5 0.5 0.5 0.5 0.5 0.5 Squalane 5.0 5.0 5.0 5.0 5.0 5.0 Caprylic Capric Triglyceride 3.0 3.0 3.0 3.0 3.0 3.0 Trioctanoine 5.0 5.0 5.0 5.0 5.0 5.0 Polysorbate 60 1.5 1.5 1.5 1.5 1.5 1.5 Sorbitan stearate 0.7 0.7 0.7 0.7 0.7 0.7 Cyclomethicone 3.0 3.0 3.0 3.0 3.0 3.0 Tocopheryl Acetate 2.0 2.0 2.0 2.0 2.0 2.0 BHT 0.05 0.05 0.05 0.05 0.05 0.05 B Purified water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Concentrated glycerin 5.0 5.0 5.0 5.0 5.0 5.0 1,3-butylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 Xanthan Gum 0.05 0.05 0.05 0.05 0.05 0.05 EDTA-2Na 0.05 0.05 0.05 0.05 0.05 0.05 Incense, preservative Quantity Quantity Quantity Quantity Quantity Quantity system 100 100 100 100 100 100

The niosomes in Table 2 contain extracts of yellowish white, cornus, rhubarb, almonds, Angelica, cloves and bands as shown in Preparation Example 8.

Experimental Example 1

The skin elasticity enhancing effect on the cosmetics containing niosomes, which stabilized the extracts of yellowish white, cornus, rhubarb, almond, Angelica, cloves and zodiac of the present invention was measured.

1) Experiment Method

Thirty healthy women (average age 29.5 years) over 20 years old were divided into three groups at a temperature of 24 to 26 ° C and a humidity of 75%, compared to Example 1 for Group A, Comparative Example 1 for Group B, and C group. Example 2 was formulated according to Table 1, respectively, and applied for 12 weeks (2 times / day) around the eyes, and then the skin elasticity was measured using a skin elasticity measuring instrument (Cutometer SEM 575, C + K Electronic Co., Germany). Measured. The experimental results are described in Table 3 as ΔR8 (R8 (12 weeks) -R8 (0 weeks)) values of Cutometer SEM 575, where R8 values represent skin viscoelasticity.

2) Experiment result

Skin elasticity (12 weeks) Experimental product Skin elasticity effect Example 1 0.45 Comparative Example 1 0.30 Comparative Example 2 0.15

As can be seen from the results of Table 3, the skin elasticity of Example 1 containing niobium stabilized extract of the active ingredient of the present invention, sulfur white, cornus, rhubarb, almond, Angelica, cloves, and strips compared to Comparative Example 1 It increased by 66.7%. Therefore, it can be seen that the six herbal ingredients and one herbaceous plant used in the present invention effectively enhance skin elasticity.

Experimental Example 2.

The moisturizing effect of the cosmetics containing niobium stabilized the extracts of sulfur white, cornus, rhubarb, almonds, Angelica, cloves, and strips of the present invention were measured.

1) Experiment Method

Example 1, Comparative Example 1 and Comparative Example 2 were formulated according to Table 2 for 30 healthy women (average age 29.5 years) indoors at 25 ° C, 45% relative humidity and no air flow. After coating three times for 6 weeks, the transdermal moisture loss, that is, the TEWL (Transepidermal Water Loss) value, was measured by TEWAMETER TM210 (C + K electronic GmbH. The moisturizing effect was measured by quantifying the moisture content of the skin from 0 to 150 using the CORNEOMETER CM 820 PC (C + K electronic GmbH. Germany). The experimental results are shown in Table 4 below.

In addition, Example 1 and Comparative Example 1 were formulated according to Table 2, respectively, in order to see the persistence of the moisturizing effect of the present invention, and after applying for 1 hour, the TEWAMETER TM210 (C + K electronic GmbH.Germany Transdermal moisture loss (TEWL), ie TEWL value change ΔTEWL over time, and CORNEOMETER CM 820 PC (C + K electronic GmbH. Germany) The electrical conductivity was measured to measure the persistence of the moisturizing effect. The test results are shown in Table 5 below.

2) Experiment result

Skin moisturizing effect Experimental product △ TEWL Corneometer value Example 1 6.5 105 Comparative Example 1 5.1 83 Comparative Example 2 1.2 65

Persistence of Moisturizing Effect Experimental product △ TEWL Corneometer value 2hr 4hr 6hr 2hr 4hr 6hr Example 1 10.1 13.4 15.7 98 95 90 Comparative Example 1 8.9 11.2 13.5 80 73 65

As a result, the ΔTEWL value of Example 1 was 5.8 g / hm ^2, and compared to Comparative Example 1, the transdermal moisture loss amount was improved 69 ± 5% after 6 weeks, and showed a very good improvement effect. In addition, it can be seen that Example 1 is also increased by 30.5% and 45.5%, respectively, in the Corneometer value in which the moisture content of the skin is measured, so that the skin is very moist.

Example 1 containing the niosomes of the present invention also in the persistence for the moisturizing effect is that the loss of moisture is rapidly increased over time, so that the skin is moisturized for a long time, which is a general emulsified particles This is because the particle size is smaller and easier to penetrate the skin, thereby increasing the durability of the moisturizing effect.

Experimental Example 3.

The skin penetration effect of the active ingredient of the present invention, baekbaek, cornus, rhubarb, almonds, Angelica, cloves and strip extracts were measured.

1) Experiment Method

Dermal Equivalent (DE)-Human normal fibroblast 1x10 ⁵ cells / ml cells in collagen gel structure similar to the fibrous tissues that form the human connective tissue. Collagen solution 3mg / ml: 5X DMEM: 2.2% sodium bicarbonate and 200mM Hepes buffer Inoculated in a medium mixed with 7: 2: 1 containing 0.05N sodium hydroxide and incubated for 7 days at 5% CO ² , 37 ° C-is distinguished from the inside and the outside by a membrane made of 3㎛ porous polycarbonate Inoculate 1x10 ⁵ cells / ml of epidermal keratinocytes on the surface of Dermal Equivalent (DE) on which fibroblasts were cultured, and put K-SFM medium containing EGF and BPE inside and outside for 7 days. Incubate. Afterwards, the medium inside the plate was discarded to allow the air to come into contact with the surface of the cultured cells, followed by incubating for 2 weeks in a medium in which K-SFM containing 10% FBS and DMEM without EGF were mixed in the same amount and incubated for 2 weeks. Obtain artificial skin with epidermis and dermis. Here, Example 1 and Comparative Example 1 of the present invention were applied to the artificial skin tissue of the top layer, followed by 4 hours of incubation in a medium in which K-SFM containing 10% FBS and DMEM without EGF were mixed in the same amount. The amount of extract that penetrated the epidermis and dermis of artificial skin was analyzed by HPLC. The experimental results are shown in Table 6 below.

2) Experiment result

Skin penetration effect Amount of extract in medium (μl / 1ml) Example 1 Comparative Example 1 Yellow white 630 55 Cornus 550 57 rhubarb 540 44 Passerby 740 73 Donkey 620 61 cloves 760 64 belt 1250 66

As a result of the experiment, Example 1 containing niobium stabilized the extract of the active ingredient of the present invention, yellow white, cornus, rhubarb, almond, tang, clove and zodiac, It can be seen that the penetration effect is superior to about 10 to 20 times compared to Comparative Example 1 using the extract as it is. This is because the average particle size of the niosome of the present invention is very small to 100 nm or less, and skin penetration is easy. Also, the diglycerin used as an auxiliary emulsifier in the niosome of the present invention further reduces skin penetration by reducing the size of the niosome particles. Because it was easy.

Experimental Example 4. Stability test of the formulation

The stability of the formulation for the cosmetic containing niobium stabilized the extract of the active ingredient of the present invention, sulfur white, cornus, rhubarb, almonds, Angelica, cloves, and bands was measured.

1) Experiment Method

In order to test the stability of the cosmetics Example 1, Comparative Examples 1 and 2 were stored in an opaque glass container in a thermostat maintained at 45 ℃ constant for 12 weeks, and also kept completely at 4 ℃ the fully shaded refrigerator After storing for 12 weeks in an opaque glass container inside, the degree of separation and discoloration was measured. The results are shown in Table 7 below. At this time, the degree of product separation and discoloration were evaluated by classifying into the following six grades.

Product discoloration evaluation criteria:

0: no change 1: very little separation (discoloration)

2: Separate slightly (discolored) 3: Separate slightly (discolored)

4: severely separated (discolored) 5: extremely severely separated (discolored)

Separation and discoloration Temperature Discoloration degree of test substance Example 1 Comparative Example 1 Comparative Example 2 45 ℃ 0 2.0 0 4 ℃ 0 0 0

As can be seen in Table 7, Example 1 and Comparative Example 2 was stable at 45 ℃ without discoloration or separation symptoms, but stabilizes the extracts of sulfur white, cornus, rhubarb, passer, Angelica, cloves and bands of the present invention Comparative Example 1 used directly in the formulation without discoloration at 45 ℃ can be seen that the extract is unstable.

Hereinafter, based on the results of the above experimental examples, to present a cosmetic composition containing niobium stabilized extracts of sulfur white, cornus, rhubarb, almond, Angelica, cloves, and strips of the present invention. However, the composition of the present invention is not intended to be limited to the following formulation examples.

Formulation Example 1 Softening Cosmetic (Skin Lotion)

Ingredient Parts by weight Niosome 1.0 1,3-butylene glycol 5.0 glycerin 5.0 Oleyl alcohol 0.1 Polysorbate 20 0.5 ethanol 15.0 Benzophenone-9 0.05 Incense, preservative a very small amount Purified water to 100

Formulation Example 2. Nutrients (Milk Lotion)

Ingredient Parts by weight Niosome 5.0 1,3-butylene glycol 5.0 glycerin 5.0 Triethanolamine 0.5 Tocopheryl Acetate 3.0 Triglycerides 3.0 Squalane 5.0 Macadamia Nut Oil 5.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.5 Carboxyvinyl Polymer 0.2 Bietchiti 0.01 IDT-2N 0.01 Incense, preservative a very small amount Purified water to 100

Formulation Example 3. Nutrition Cream

Ingredient Parts by weight Niosome 10.0 Cetostearyl alcohol 2.0 Glyceryl Stearate 1.5 Trioctanoine 5.0 Polysorbate 60 1.2 Sorbitan stearate 0.5 Squalane 5.0 Triglycerides 3.0 Cyclomethicone 3.0 Bietchiti 0.05 Delta-tocopherol 0.2 Concentrated glycerin 5.0 1,3-butylene glycol 5.0 Xanthan Gum 0.1 IDT-2N 0.05 Incense, preservative a very small amount Purified water to 100

Formulation Example 4 Massage Cream

Ingredient Parts by weight Niosome 1.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Beeswax 2.0 Tocopheryl Acetate 0.1 Polysorbate 60 3.0 Sorbitan sesquioleate 2.5 Cetearyl Alcohol 2.0 Liquid paraffin 30.0 Carboxy Vinyl Polymer 0.5 Incense, preservative a very small amount Purified water to 100

Formulation Example 5 Pack

Ingredient Parts by weight Niosome 2.0 Propylene glycol 2.0 glycerin 4.0 Carboxyvinyl Polymer 0.3 ethanol 7.0 Fiji-40 Hydrogenated Castor Oil 0.8 Triethanolamine 0.3 Bietchiti 0.01 IDT-2N 0.01 Incense, preservative a very small amount Purified water to 100

By effectively stabilizing the extract of the active ingredient of the present invention sulfur white, cornus, rhubarb, almonds, Angelica, cloves, and strips to niosomes, to maximize the effect of the active ingredients, such as skin elasticity, continuous moisturizing effect and skin penetration enhancement Can be.

Claims (11)

Yellow White, Cornus, Rhubarb, Pedestrian, Angelica, Clove And Cosmetic composition containing niosomes which stabilized the extract of the strip. The cosmetic composition according to claim 1, which contains the extracts of sulfur white, cornus, rhubarb, almond, Angelica, cloves, and strips in an amount of 0.1 to 10% by weight based on the total weight of niosomes. The cosmetic composition according to claim 1, wherein the extracts of yellow, yellow, rhubarb, rhubarb, almonds, Angelica, cloves, and zodiac are each contained in an amount of 0.001 to 3.0% by weight based on the total weight of niosomes. The method of claim 1, wherein the niosome is 10 to 50% by weight of nonionic surfactant, 1 to 50% by weight of coemulsifier, 30 to 80% by weight of cholesterol, cholesteryl ester and soysterol relative to the total weight of niosome Cosmetic composition, characterized in that it contains a mixture of. The cosmetic composition according to claim 4, wherein the nonionic surfactant is selected from polyoxyethylene alkyl ether, polyoxyethylene alkyl ester, and saccharose diester. The cosmetic composition according to claim 4, wherein the co-emulsifier is diglycerol. The method according to claim 4, wherein the cholesteryl ester is selected from cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate and cholesteryl isostearyl carbonate. Cosmetic composition characterized in that. The cosmetic composition according to claim 4, further comprising ceramide. The cosmetic composition according to claim 9, wherein the ceramide is contained in an amount of 0.1 to 10% by weight based on the total weight of niosomes. 5. The niobium is mixed with a nonionic surfactant, an auxiliary emulsifier, cholesterol, cholesteryl ester, and soysterol, and then cooled. The niobium is sulfur white, cornus, rhubarb, almond, donkey, clove And Cosmetic composition, characterized in that it is prepared by mixing the high-pressure emulsification of the extract of the strip. The cosmetic composition according to claim 1, wherein the formulation is a softening cream, astringent makeup, nutrition cream, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, essence and pack.