KR100513082B1 - Cosmetic composition containing ceramide liposome with phyto complex extract and ceramide - Google Patents

Abstract

The present invention is an anti-aging and acne containing 0.5 ~ 30.0% by weight of ceraliposomes, including plant complex extracts of marlow, peppermint, primula, lady's mantle, spirwell herb, balmint and yarrow, and ceramide It relates to an improved cosmetic composition, according to the present invention, very easy to penetrate the skin, enhance skin elasticity, decrease the amount of water loss of keratin, anti-aging effect according to the moisturizing effect and acne improvement effect, very stable, ceramide and The cerariposome containing cosmetic composition containing a plant complex extract can be obtained.

Description

Ceramide foam containing cosmetic composition containing ceramide and plant complex extract {COSMETIC COMPOSITION CONTAINING CERAMIDE LIPOSOME WITH PHYTO COMPLEX EXTRACT AND CERAMIDE}

The present invention relates to a cosmetic composition, and to a cosmetic composition having an anti-aging and acne-improving effect by containing a cerariposome including ceramide and a plant complex extract.

Liposomes are generally made of phospholipids. These phospholipids consist of hydrophobic long hydrocarbon chains and hydrophilic polar groups, and the hydrophobic long hydrocarbons consist of sphingosine derivatives or glycerol derivatives. The other side has ester linkages with choline, ethanol amine, serine, inositol or glycerol. Phospholipids form these regularly arranged structures in the water medium, namely micelles or lamellar structures.

Liposomes are also similar in structure to biological membranes and are being studied as membrane model systems and physiological delivery media (R. Sundler. D. Papahadjpovlos, Biochim. Biophys. Acta, 648.743 (1981)). It is also widely used in cosmetics and food. Such liposomes can be delivered stably without breaking the physiologically active ingredient, and have the advantage of containing both the soluble and water-soluble physiologically active ingredients.

Such liposomes are largely divided into multi-membrane liposomes (MLV: Multilamella vesicle) and mono-membrane liposomes (ULV: Unilamella vesicle), and ULV can be divided into large Unilamella vesicles and small Unilamella vesicles. MLV is 400-3500 nm in size and 5-15% of the amount can be contained in liposomes. LUV has a size of 100-1,000 nm, 36-65% of the amount can be contained in liposomes, and SLV has a size of 20-50 nm, and 0.5-1.0% of the amount can be contained in liposomes. The amount of bioactive substances that can be contained is the most LUV but unstable, SLV is the most stable but the amount that can contain less. In addition, since the structure of human skin has a structure of multilamellar, MLV has affinity with the skin, but MLV is too large to penetrate the skin.

On the other hand, ceramide is a major component of keratinocyte lipids of the stratum corneum, which occupies 50% of all lipids of the stratum corneum, and forms a lipid double layer with moisture to provide anti-humidity and barrier function. The ceramides are arranged side by side in a layered structure, and water is filled therebetween to maintain moisture, so that the layered structure exhibits an overall barrier function.

However, such ceramides are very hydrophobic and have a high tendency to crystallize, making it difficult to develop effective formulations containing them, thus making them difficult to apply to the skin. In order to solve this problem, liposomes were used to increase the content of ceramide in the composition, but there is a problem that stability is unstable when applying high content (Korean Journal of Skin Barriers, Vol. 2, No. 1, C & T Vol. 111, Dec. 1996).

Mallow (Malva sylvestris) is a perennial plant of mallow, 60 to 150 cm in length, to treat inflammation and diseases of the respiratory system, toxin release and to reduce constipation. It contains arabinose, glucose, rhamnose, galactose, etc. and it can be used to make up the face and thinn the blemishes and freckles. The mucus of roots is especially effective for soothing and analgesic (Kim Tae-jung, Korean resource plant, Vol. 3, 89P).

Peppermint (Mentha piperita) is a medicinal herb that is used as a medicine to relieve diseases of the digestive and respiratory system.It is a medicine for gastrointestinal diseases, headache, cholera, diarrhea, hysteria, neuralgia, rheumatism, toothache, acid fever and colic. Used as antiperspirant and antiseptic. Contains menthol and flavonoids, which expand the capillaries, cooling to relieve itching, inflammation and sunburn. It softens the skin, eliminates acne, and is effective for oily and oily hair.

Primula (Primula veris) is a plant belonging to the primrose family, contains a lot of saponins, triterpenoids, aglycones, and phenolic glucosides, which promote healing of wounds, inhibit inflammation, and promote new shoots when used locally. .

Ladysmantle (Alchemilla vulgaris) is a plant belonging to the family Rosaceae, which contains tannins, flavins, glutinous oil and some essential oils, and is widely used for wound healing.

Speedwell herb (Veronica officinalis) contains glucosides, veronicosides, flavonoids, tannins, caffeic acid, etc., it is effective for skin moisturizing, antioxidant and astringent.

Melissa officinalis is a perennial herbaceous plant that contains monoterpenoids, glucosides, aglycones, and caffeic acid.It prevents drying, moisturizes, soothes and heals, promotes digestion, promotes stomach dryness, oral deodorization Used.

Yarrow (Achillea millefolium) is a perennial herb, poultice and cleanser is effective for acne, eczema and rough skin. In addition, sterilization, astringent power, hemostatic power to cut the cuts and nosebleeds hemostatic action and disinfection. In addition, it has the effect of blood purification, diuretic, and sweating (Kim Tae-jung, Korea's resource plant, Vol. 4, 252P).

It is an object of the present invention to provide a cosmetic composition in which a complex extract of ceramide and certain plants is stabilized with cerarisomes, while having excellent skin moisturizing effect, elasticity effect, anti-aging effect and acne improvement effect, and easy to penetrate into the skin. have.

In order to achieve the above object, according to the present invention, the cerariposomes comprising plant complex extracts and ceramides of marlow, peppermint, primula, lady's mantle, spirwell herb, balmint and yarrow are 0.5 to 0.5 g with respect to the total weight of the cosmetic composition. An anti-aging and acne improving cosmetic composition containing 30.0% by weight is provided.

Hereinafter, the present invention will be described in more detail.

The plant complex extract, after completely drying each of the marrow, peppermint, primula, lady's mantle, spirwell herb, balmint and yarrow, and physically pulverized, after mixing the pulverized plant in a specific ratio, the extraction solvent Add and extract.

At this time, the extract of Marlow is root, peppermint is leaf, primula is root and branch, lady's mantle is flower, spiwell herb is root, balmint is leaf, yarrow is flower and branch. great.

The pulverized plant is 50 to 59: 25 to 50: 10 to 25: 5 to 10: 1 to 5: 0.1 to 1: 0.01 of marlow, peppermint, primula, lady's mantle, spirwell herb, balmint and yarrow The mixture is used in a weight ratio of ˜0.1. When mixed in the above ratio, not only the efficacy of each plant extract is evenly expressed but also the maximum synergistic effect.

As the extraction solvent, 50% glycerin, ethanol, butylene glycol, etc. may be used, but it is preferable to use 50% glycerin to increase the moisturizing power on the skin.

The extraction is carried out under 600-900 mmHg with heating of 80 to 90 ° C. for 8 to 12 hours after adding 3 to 5 weight times of extraction solvent to the plant mixture, followed by filtration.

The plant complex extract thus obtained is mixed with vesicles and ceramides formed using lecithin, propylene glycol, and nonionic surfactants, and then mixed with water to form ceraliposomes. Such ceraliposomes are 10-200 nm in size, protecting and stabilizing the active ingredient and facilitating the penetration of the active ingredient into the skin.

Referring to the method of forming the cerliposome in detail as follows.

A vesicle is formed by heating the lecithin, propylene glycol and nonionic surfactant to 80-85 ° C. and mixing thoroughly.

The lecithin, propylene glycol and nonionic surfactants are mixed at a weight ratio of 8 to 12:40 to 60: 1 to 2, and 30 to 50% by weight, preferably 30 to 35% by weight, based on the total weight of ceraliposomes. Add. By mixing and adding in such a ratio, good stability and viscosity can be obtained at an appropriate cost.

Subsequently, 100% by weight of water is mixed by mixing the plant complex extract with ceramide while mixing and homogenizing.

The plant complex extract is added to 0.1 to 10% by weight, preferably 0.1 to 5% by weight, based on the total weight of ceraliposomes. When added in less than 0.1% by weight is almost no effect, when added in excess of 10% by weight it is preferable to add 0.1 to 10% by weight since the stability is reduced.

The ceramide is added to 0.1 to 10% by weight, preferably 0.1 to 1% by weight based on the total weight of ceraliposomes. When added in less than 0.1% by weight has little effect, when added in excess of 10% by weight it is not possible to use in cosmetics because the viscosity is high, it is preferable to add 0.1 to 10% by weight.

The resulting mixture is then homogenized at 600-1000 bar with a microfluidizer to obtain ceraliposomes. That is, ceramides having a closed bilayer structure are prepared by emulsifying a mixture of ceramide and plant complex extract in a vesicle.

The cerariposome obtained can be added to all cosmetics related to anti-aging and acne improvement, such as essences, nutrition cream, etc., the amount is preferably added in 0.5 to 30% by weight relative to the total weight of the cosmetic composition. If it is less than 0.5% by weight can not expect a clear anti-aging and acne-improving effect, if it exceeds 30% by weight there is a problem in the stability and the price is not practical because it is expensive.

The following Examples, Comparative Examples, Preparation Examples, and Test Examples are provided to explain the present invention in more detail, and the scope of the present invention is not limited thereto.

Example

(Example 1)

Preparation of Liposomal Bsicles

Lecithin, propylene glycol, nonionic surfactants were weighed at the ratio of the following Table 1 (A) and completely dissolved and mixed while heating to 80 to 85 ° C to prepare vesicles.

(Production of Plant Complex Extract)

The dried Marlow, Peppermint, Primula, Lady's Mantle, SpiwellHub, Balmint and Yarrow, which were dried until there was no change in weight, were mechanically ground. These were weighed and mixed at a weight ratio of 55: 30: 15: 10: 5: 1: 0.1, respectively. To this, 50% glycerin was added 4 times by weight, extracted at 700 mmHg while heating at 90 ° C. for 10 hours, and filtered through 400 mesh.

(Production of Plant Extract)

The dried Marlow, Peppermint, Primula, Lady's Mantle, SpiwellHub, Balmint and Yarrow, which were dried until there was no change in weight, were mechanically ground. 4% of 50% glycerin was added thereto, and the mixture was extracted at 700 mmHg while heating at 90 ° C. for 10 hours, and filtered through 400 mesh, and each of marlow, peppermint, primula, lady's mantle, spielwell herb, balmint and yarrow An extract was prepared.

(Preparation of Cerraposome with Stabilized Ceramide and Plant Complex Extract)

To the liposome vesicle (A) obtained above, the ceramide (C) and the plant complex extract (B) were homogenized while slowly adding in the ratio shown in Table 1 below. Then, purified water (D) was homogenized while mixing in the ratio of Table 1 below. The homogenized was homogenized by two treatments at a rate of 15 liters / hour at a pressure of 600 bar using a high pressure homogenizer (manufactured by Microfluidic Corp, Microfludizer 110T 90014), and then gradually cooled to obtain ceraliposomes.

(Manufacture example 1)

Preparation of plant complex extract-containing cosmetic

To prepare a cream according to the conventional method for preparing a cosmetic using the composition of Table 2 (including the plant complex extract prepared in Example 1).

(Comparative Production Examples 1 to 7)

Preparation of Cosmetic Extract-Containing Cosmetics

Instead of using the plant complex extract, the cream was prepared in the same manner as in Preparation Example 1, except that the Marlow, Peppermint, Primula, Lady's Mantle, SpiwellHub, Balmint and Yarrow extracts prepared in Example 1 were used. Prepared.

(Test Example 1)

Skin elasticity effect

The eighty healthy women (average age 29.5 years old) of 20 years old or older (mean age 29.5 years old) were divided into eight groups of 10 people each at a temperature of 22 to 24 ° C and a relative humidity of 55%, and the cosmetic compositions of Preparation Examples 1 and 7 were compared. After 12 weeks of application (2 times / day), the skin elasticity was measured using a skin elasticity measuring instrument (Cutometer SEM 575, C + K Electronic Co., Germany). The results are shown in Table 3 as an average value for each test group.

The improvement was calculated according to the following equation.

Improvement (%) = (△ R5 / Before Application) X 100

ΔR5 value = [R5 (12 weeks) -R5 (0 weeks)]

The value of R5 is a value representing the actual modulus of elasticity, and when the value is close to 1, it indicates that the elasticity is better.

(Test Example 2)

Skin moisture improvement

The subjects were divided into 8 groups of 10 healthy women (average age 29.5 years) in the room with 22 ~ 24 ℃, 55% relative humidity and no air flow. The cosmetics of Preparation Example 1 and Comparative Preparation Examples 1 to 7 were applied (two times / day) for six weeks to the entire face around the eyes of each group. By using Skicon-200 (IBS Co. Japan), the moisture content of the cheek area was measured before and after application to measure the persistence of the moisturizing effect. The results are shown in Table 3 as an average value for each test group.

The improvement was calculated according to the following equation.

% Improvement = (6 weeks after application-before application) / before application X 100

(Test Example 3)

Acne Improvement

In order to measure the effect of inhibiting the growth of bacteria against acne bacteria, after spreading the acne bacteria ( Streptomyces bikiniensis ) on a solid flat medium, 20 μl of the cosmetic composition of Preparation Example 1 and Comparative Preparation Examples 1 to 7 were dropped to the center of the air and dried naturally. After culturing at 37 ° C. for 24 hours, the size of the suppressed ring was measured. The results are shown in Table 3 below.

According to Table 3 above, when the mixture of Marlow, Peppermint, Primula, Lady's Mantle, SpiwellHub, Balmint and Yarrow extracts is used in a specific ratio, the skin elasticity improvement, skin moisture improvement, acne The improvement effect appeared to increase.

(Manufacture example 2)

Preparation of Ceraliposomal-Containing Cosmetics

To prepare a cream according to the conventional cosmetic preparation method using the composition of Table 4 (including the plant complex extract prepared in Example 1 and the ceramide stabilized ceramide).

(Comparative Production Example 8)

Preparation of plant complex extract-containing cosmetic

To prepare a cream according to the conventional method for preparing a cosmetic using the composition of Table 4 (including only the plant complex extract prepared in Example 1).

(Comparative Production Example 9)

Preparation of ceramide-containing cosmetic

To prepare a cream according to the conventional method for preparing a cosmetic using the composition of Table 4 (including only ceramide).

(Comparative Production Example 10)

Preparation of Cosmetics Containing Ceramide and Plant Complex Extract

To prepare a cream according to the conventional method for preparing a cosmetic using the composition of Table 4 (including ceramide and the plant complex extract prepared in Example 1).

(Comparative Production Example 11)

Using the composition of Table 4 (ceramide, plant complex extract, cerariposome free) to prepare a cream according to the conventional manufacturing method of the cosmetic.

(Test Example 4)

Skin elasticity effect

Skin elasticity was measured in the same manner as in Test Example 1, except that 25 females (5 groups of 5 persons) were used for the cosmetic compositions of Preparation Example 2 and Comparative Preparation Examples 8 to 11.

The results are shown in Table 5 below.

In Table 5, the skin elasticity when the ceramide and the plant complex extract containing the stabilized ceraliposome-containing cosmetics (Preparation Example 2) is used, 30.19% compared to Comparative Preparation Example 8, 30.12%, compared to Comparative Preparation Example 9 24.64% compared with Example 10 and 31.49% compared with Comparative Production Example 11. Therefore, it can be seen that the cerariposomes stabilized the ceramide and the plant complex extract according to the present invention effectively promote skin elasticity than the ceramide and the plant complex extract as they are or used individually.

(Test Example 5)

Measurement of moisture loss in the stratum corneum

For the cosmetic compositions of Preparation Example 2 and Comparative Preparation Examples 8 to 11, the moisture loss amount of the stratum corneum was measured according to the change of time.

The experimental method was as follows.

25 healthy women (average age 29.5 years old) divided into 5 groups of 5 healthy women at 22-24 ° C, 55% relative humidity and no air flow. Apply it to the entire face as a center and view transepidermal water loss (TEWL) using TEWAMETER TM 210 (C + K electronic GmbH. Germany) 1, 2, 4 and 6 hours after application. Measured at the site. The experimental results are shown in Table 6 below.

In Table 6, the ceramide and plant complex extract containing the stabilized ceramide and plant extract according to the present invention (Preparation Example 2), the ceramide and the plant extract is used as is, or used separately, which is an indicator of the water retention of the stratum corneum The epidermal loss was remarkably improved after 6 hours.

(Test Example 6)

Skin moisture improvement

The skin moisture content improvement effect was measured in the same manner as in Test Example 2, except that 25 females (5 groups of 5 persons) were applied to the cosmetic compositions of Preparation Example 2 and Comparative Preparation Examples 8 to 11.

The results are shown in Table 7 below.

According to Table 7, the ceramide and plant-derived ceramide according to the present invention stabilized cosmetic preparations containing ceramide (preparation Example 2) is smaller than the general emulsified particles compared to the case where the skin moisture content is used as the ceramide and the plant complex extract as it is It is easy to penetrate the skin and increase the persistence of the skin moisturizing effect.

(Test Example 7)

Skin penetration effect

The skin permeation effect of the cosmetic compositions of Preparation Example 2 and Comparative Preparation Examples 8 to 11 was measured by the following method.

DE (Dermal Equivalent) 1x10 ⁵ cells / ml of normal human fibroblasts, 3mg / ml collagen aqueous solution: 5X DMEM: 2.2% sodium bicarbonate and 200mM Hepes buffer in a collagen gel structure similar to the fibrous tissues of human connective tissue Inoculated in a medium mixed with 7: 2: 1 of 0.05 N sodium hydroxide, and incubated for 7 days at 5% CO ₂ at 37 ° C.) The cells were formed inside and outside by a membrane made of 3 μm porous polycarbonate. Placed inside this separated plate, inoculated with epidermal Keratinocyte 1x10 ⁵ cells / ml on the surface of the cultured DE cells, and put the K-SFM medium containing EGF and BPE inside and outside 7 days Incubated for Subsequently, the medium inside the plate was removed to allow air to come into contact with the surface of the cultured cells, followed by incubating for 2 weeks in a medium in which K-SFM containing 10% FBS and DMEM without EGF were mixed in the same amount. , Artificial skin with multilayer epidermis and dermis was obtained.

Here, Preparation Example 2 and Comparative Preparation Examples 8 to 11 of the present invention were applied to the artificial skin tissue of the top layer. After 4 hours of incubation, the amount of ceramide and plant extract extracted by penetrating the epidermis and dermis of artificial skin in the same amount of K-SFM containing 10% FBS and DMEM without EGF was measured by HPLC. Analyzed. The test results are shown in Table 8 below.

In Table 8, the ceramide and plant complex extract containing the stabilized ceramide and plant extract according to the present invention (Preparation Example 2) is excellent in penetration about 5 times better than using the ceramide and plant extract as it is or individually used. Able to know. As a result, the cerariposome of the present invention has a very small average particle size. It was found that skin penetration was easy.

(Test Example 8)

Acne Improvement

Except for using the cosmetic composition of Preparation Example 2 and Comparative Preparation Examples 8 to 11 was tested the inhibitory effect of acne bacteria in the same manner as in Test Example 3.

The test results are shown in Table 9 below.

In Table 9, the ceramide and plant complex extracts containing the stabilized ceramide and plant extracts according to the present invention (Preparation Example 2) is about 2 times to 5 times acne than the ceramides and plant complex extracts used as it is or used separately. It was able to inhibit the bacteria.

(Test Example 9)

Formulation Stability Test

The stability of the formulation was measured for the cosmetic compositions of Preparation Example 2 and Comparative Preparation Examples 8 to 11. The experimental method was as follows.

Samples 2 and Comparative Preparation Examples 8 to 11 were stored in an opaque glass container in a constant temperature bath at a constant temperature of 45 ° C. and stored for 12 weeks in an opaque glass container in a completely shaded refrigerator kept at 4 ° C. The degree of separation and discoloration of the sample stored for 12 weeks and the sample stored for 12 weeks in a circulation chamber circulating at -5 ° C to 37 ° C were measured. The results of the evaluation of the product separation and discoloration graded to the following six grades are shown in Table 10 below.

Discoloration evaluation criteria: 0: No change 1: Very little separation (discoloration)

2: Separate slightly (discolored) 3: Separate slightly (discolored)

4: severely separated (discolored) 5: extremely severely separated (discolored)

In Table 10, the ceramide and plant complex extract containing the stabilized ceramide and plant extract according to the present invention (Preparation Example 2) 4 ℃, 45 ℃, circulating test than using the ceramide and plant extract as it is or used separately No discoloration or separation symptoms were found to be stable.

(Comparative Production Example 12)

A cream was prepared according to the conventional method for preparing a cosmetic using the composition shown in Table 11 (content of ceraliposome 0.3% by weight).

(Manufacture example 3)

A cream was prepared according to the conventional method for preparing a cosmetic using the composition of Table 11 (content of ceraliposome is 0.5% by weight).

(Comparative Production Example 13)

Using the composition shown in Table 11 (content of ceraliposome 35% by weight), a cream was prepared according to a conventional cosmetic preparation method.

(Test Example 10)

Skin elasticity effect

Skin elasticity of the cosmetic compositions of Preparation Examples 2 and 3 and Comparative Preparation Examples 12 and 13 was measured in the same manner as in Test Example 1, except that 20 women (4 groups of 5 people) were used.

The results are shown in Table 12 below.

(Test Example 11)

Measurement of moisture loss in the stratum corneum

Except using the cosmetic compositions of Preparation Examples 2 and 3 and Comparative Preparation Examples 12 and 13, the moisture loss amount of the stratum corneum was measured in the same manner as in Test Example 5.

The experimental results are shown in Table 13 below.

(Test Example 12)

Skin moisture improvement

The cosmetic composition of Preparation Examples 2 and 3 and Comparative Preparation Examples 12 and 13 was measured in the same manner as in Test Example 2 except that 20 women (4 groups of 5 people) were measured.

The results are shown in Table 14 below.

(Test Example 13)

Skin penetration effect

The skin penetration effect was measured in the same manner as in Test Example 7, except that the cosmetic compositions of Preparation Examples 2 and 3 and Comparative Preparation Examples 12 and 13 were used.

The results are shown in Table 15 below.

(Test Example 14)

Acne Improvement

Except that the cosmetic compositions of Preparation Examples 2 and 3 and Comparative Preparation Examples 12 and 13 were used, the inhibitory effect of acne bacteria was tested in the same manner as in Test Example 3.

The test results are shown in Table 16 below.

(Test Example 15)

Formulation Stability Test

The stability of the formulation was tested in the same manner as in Test Example 9, except that the cosmetic compositions of Preparation Examples 2 and 3 and Comparative Preparation Examples 12 and 13 were used.

The results are shown in Table 17 below.

From the results of Tables 12 to 17, the anti-aging and acne-improving effect is too small when the cerariposome is contained in less than 0.5% by weight relative to the total weight of the cosmetic, the formulation is unstable when contained in more than 30.0% by weight Since separation and discoloration occur, it was found that 0.5 to 30.0 wt% is preferable.

(Manufacture example 16)

Essence was prepared according to the conventional method for preparing a cosmetic composition with the composition of Table 18.

(Manufacture example 17)

To the nutrition of the cream according to the conventional method for producing a cosmetic composition with the composition of Table 19.

According to the present invention, it is very easy to penetrate into the skin, the skin elasticity, the loss of moisture of keratin, the anti-aging effect and the acne-improving effect according to the moisturizing effect, both excellent and very stable, ceramide and plant complex extract containing A liposome containing cosmetic composition can be obtained.

1 is an enlarged view of 84,000 times of cerariposome containing ceramide and plant complex extract according to the present invention;

Figure 2 is a 120,000-fold enlarged view of cerariposomes containing ceramide and plant complex extract according to the present invention.

Claims (5)

An anti-aging cosmetic composition containing 0.5 to 30.0% by weight of ceraliposomes, including plant complex extracts of marlow, peppermint, primula, lady's mantle, spirwell herb, balmint and yarrow, and ceramide. The method of claim 1, The plant complex extract is 50 to 59: 25 to 50: 10 to 25: 5 to 10: 1 to 5: 0.1 to 1: 0.01 to Marlow, peppermint, Primula, Lady's Mantle, Spiwell herb, Balmint and Yarrow Anti-aging cosmetic composition, characterized in that extracted by mixing at a ratio of 0.1. The method of claim 1, The ceraliposome is an anti-aging cosmetic composition, characterized in that consisting of plant extract, ceramide, lecithin, propylene glycol, nonionic surfactant and water. The method of claim 1, The plant composite extract is an anti-aging cosmetic composition, characterized in that it is contained in an amount of 0.1 to 10% by weight in the cerariposome. The method of claim 1, The ceramide is an anti-aging cosmetic composition, characterized in that it is contained in the content of 0.1 to 10% by weight in the ceraliposomes.