KR100713555B1 - Composition for Protection of Hair comprising Ceramide Stabilized in Nanoliposome as Active Ingredient - Google Patents

Abstract

The present invention relates to a hair protection composition containing nanoliposomes stabilized by inclusion of ceramide as an active ingredient, wherein the composition of the present invention includes a ceramide, which is one of hair structural lipids acting as an intercellular binding material, on a nanoliposome. By stabilizing, it is very excellent in facilitating hair penetration, improving hair function, and strengthening moisturizing force to give softness and gloss in normal hair as well as recovery of damaged hair.

Ceramides, nanoliposomes, hair protection, compositions

Description

Composition for Protection of Hair comprising Ceramide Stabilized in Nanoliposome as Active Ingredient}

The present invention relates to a composition for protecting hair containing nanoliposomes incorporating ceramide as an active ingredient.

Although hair is not directly related to life, it has functions of protecting the body, keeping warm and tactile, acting as a cushion against friction from the outside, protecting hair from direct sunlight, cold and heat. Play a role. In addition, eyebrows, eyelashes, nose hairs and ear hairs have a protective function against invasion of sweat, dust and insects. Hair not only protects the head, but also has the function of absorbing heavy metals such as mercury, arsenic and lead that are not needed by the body and discharging them out of the body. In addition, hair plays an important role in showing male and female characteristics in terms of decoration. Even the same person can make a different impression by changing the hairstyle and hair color. Thus, hair plays a decorative role as well as to protect the head.

Hair is a thin, thin protein structure with an average thickness of about 0.07 mm, which can be roughly divided into a hair shaft extending out of the skin and a hair root inside the skin. The scalp has a basic structure and physiological function similar to that of the skin, and the hair follicles of the scalp are more complex and more sebaceous than other areas. Root part is the part inside the hair follicle, buried in the scalp, about 2-4 mm deep. The bottom of the hair root is swollen like a bead, which is called a hair bulb, and the size of the hair determines the thickness of the hair.

The enlarged cross section of the hair is divided into three parts: the innermost and central part of the medulla, the cortex surrounding the medulla, and the outermost cuticle. The cuticle covers the surface of the hair and has a strong chemical resistance covering the inside of the hair, and is composed of three layers called epicuticle, exocuticle and endocuticle from the outside. Cortex is located inside the cuticle and accounts for most of hair (85-90%). Its main component is keratin protein, which is composed of cortical cells and intercellular binding materials, and is hydrophilic and easily affected by perm and dyeing. . The medulla is located in the center of the hair, has some melanin pigment particles, and there is a lot of fear in the medulla, which contains air.

Modern people are damaging their hair with perm, drying and dyeing, and frequent haircuts are inevitable due to various hair dressings and air pollution. However, despite many efforts to restore hair damaged by frequent chemical treatment and hair removal to its original healthy state, the results have been small. This is because hair constituents, unlike other living tissues, are dead tissues, which limits the ability to save damaged areas.

Ceramide is one of the structural lipid components of hair and is an essential component of hair. These structural lipids act as intercellular binders responsible for the adhesion and binding of cells present in the hair cuticle and cortex of the hair, which plays a very important role in hair barrier function and hair retention. Hair needs some moisture for flexibility and elasticity. Maintaining a constant moisture content of the hair is important for maintaining the health of the hair. When combing in a low humidity condition, static electricity is generated and accumulated by friction, which causes hair to float and dust. Combing also worsens, damaging hair. However, such structural lipids, such as ceramides, do not penetrate the hair well by the distribution of very long carbon, so it is difficult to expect the effect properly compared to the amount used.

Recently, attempts have been made to restore damaged hair structure by effectively infiltrating hair with ceramide, a structural lipid component of hair that acts as an intercellular binding material.

Korean Patent Registration No. 182,599 discloses the preparation of capsules containing cholesterol, long chain fatty acids, long chain fatty alcohols, ceramides, and the like, and prescribing them appropriately in products. -249525 discloses a technique for formulating natural waxes, mixed waxes in glass form or encapsulated in capsules and formulating the product.

In the former case, the ceramides used are expensive and expensive to encapsulate, which is economically undesirable. In addition, since the capsule is secured in stability, even when the active ingredient is kept in the capsule, when applied to the hair, it is difficult to adsorb and penetrate, so it is difficult to fully expect the effect. In addition, when natural wax is encapsulated in a glass or capsule and formulated in a prescription, the pretreatment is complicated because the wax is dissolved, then cooled using a suitable cooling device, a mixed complex is formed, and then encapsulated in a capsule and blended into a product. Not only is it costing a lot of money, but after applying hair, it provides a primary hair feeling such as improving the feel and improving the feeling of combing after drying.

Therefore, there is an urgent need for the preparation of new hair compositions that can facilitate hair penetration of ceramide, which is one of the structural lipid components of hair, improve hair function, and enhance moisturizing power.

Throughout this specification, numerous patent documents are referenced and their citations are shown in parentheses. The disclosure of the cited patent documents is incorporated herein by reference in their entirety, and the level of the technical field to which the present invention belongs and the contents of the present invention are more clearly explained.

The present inventors earnestly researched to develop a hair protection composition which is excellent in strengthening the moisturizing power to improve the function of the hair, restoring damaged hair as well as providing softness and gloss in normal hair. The present invention was completed by confirming that the ceramide, which is one of the hair structure lipids acting as a clathrate, can be exerted in the nanoliposomes.

Therefore, it is an object of the present invention to provide a composition for protecting hair containing nanoliposomes stabilized by inclusion of ceramide.

Other objects and advantages of the present invention will become apparent from the following detailed description and claims.

According to an aspect of the present invention, the present invention provides a composition for protecting hair containing nanoliposomes stabilized by inclusion of ceramide as an active ingredient.

Ceramide (Ceramide) included in the hair protection composition of the present invention is one of the hair structure lipids that occupies about 40-50% of the lipid component between keratinocytes as a component present in the stratum corneum of the skin epidermis. Such ceramide forms a multiple lamellar structure between keratinocytes along with other keratinocyte lipid components, thereby inhibiting evaporation from the skin and maintaining moisture to soften the skin and keep the skin healthy.

The ceramide may be any kind of ceramide, and preferably at least one ceramide selected from the group consisting of ceramide 3, ceramide-6 and pseudoceramide.

Liposomes are defined as spherical phospholipid vesicles of colloidal particles that associate themselves. Liposomes composed of amphiphilic molecules with water-soluble heads (hydrophilic groups) and insoluble tails (hydrophobic groups) spontaneously interact with them. Combined and ordered structure. Liposomes are classified into Small Unilamellar Vesicle (SUV), Large Unilamellar Vesicle (LUV), Multi Lamellar Vesicle (MLV) and the like according to their size and lamellarity. These liposomes exhibiting various laminations are about 20 nm-hundreds of nm in size, have a double membrane structure similar to cell membranes, and are about 4 nm thick. Liposomes made from natural lipids such as lecithin are more biodegradable and biocompatible than liposomes made from synthetic lipids, so that water-soluble components are present in the aqueous core and oil-soluble components are present in the phospholipid membrane. It is solubilized to encapsulate both hydrophilic and lipophilic materials. Liposomes can contain various active substances, fragrances, drugs, vaccines, etc., and substances entrapped in liposomes are released slowly over time.The release of clathrates is enhanced by strengthening the rigidity of the double membrane. Can be adjusted.

To date, studies using liposomes have been actively conducted by various researchers. However, most of its uses are "promoting transdermal absorption of active ingredients" (Korean Patent Application Nos. 2000-0008212 and 2000-0042399), "Enhancing Skin Moisturizing" (Korean Patent Application No. 1994-7004646), "Atopic Dermatitis" And improvement of dry skin ”(Korean Patent Application No. 2000-0027165). In addition, in the study of the conventional cosmetic composition using liposomes, the liposomes were destroyed before the active ingredient was absorbed into the skin, and thus the desired effects could not be achieved.

However, the hair protection composition of the present invention includes nanoliposomes that are significantly smaller particles than the liposomes described above as an active ingredient, and includes the ceramide, which is a hair lipid component, in the nanoliposomes as an active ingredient.

As used herein, the term "nanoliposomes" refers to liposomes having an average particle diameter of 1-100 nm as having the form of conventional liposomes. According to a preferred embodiment of the invention, the average particle diameter of the nanoliposomes is 30-70 nm. When the average particle diameter of the nanoliposomes exceeds 70 nm, the improvement of hair penetration and the improvement of formulation stability are very weak among the technical effects to be achieved in the present invention.

In the present specification, the inclusion of ceramide in nanoliposomes does not mean that the ceramide is located at the innermost part of the nanoliposomes, such as a water-soluble substance. It means to be included.

According to a preferred embodiment of the present invention, the content of the nanoliposomes is 0.1-20.0% by weight, preferably 1.0-10.0% by weight relative to the total weight of the composition. In addition, the content of the ceramide is 1.0-30.0% by weight, preferably 3.0-20.0% by weight relative to the total weight of the nanoliposomes.

According to a preferred embodiment of the present invention, the nanoliposomes of the present invention comprise (i) an oily component comprising polyol, (ii) ceramide and cholesterol, (iii) surfactant, (iii) phospholipid, (iii) fatty acid and (iii) It is prepared by a mixture containing water, characterized in that the mixture does not contain a monohydric alcohol.

The polyol used in the nanoliposome of the present invention is not particularly limited, and preferably, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, methyl propanediol, isoprene glycol, pentylene glycol, erythritol, xyitol, Sorbitol and mixtures thereof. It is preferably selected from the group consisting of propylene glycol, 1,3-butylene glycol, glycerin and mixtures thereof, most preferably glycerin. The amount used is 10-80% by weight, preferably 30-70% by weight based on the total weight of the nanoliposomes.

The oil component used in the preparation of the nanoliposomes of the present invention may be various oils known in the art, preferably hydrocarbon-based oils such as hexadecane and paraffin oil in addition to ceramide and cholesterol; Synthetic synthetic oils; Silicone oils such as dimethicone and cyclomethicone series; Animal and vegetable oils such as sunflower oil, corn oil, soybean oil, avocado oil, sesame oil, jojoba oil, squalane and fish oil; Ethoxylated alkyl ether oils; Propoxylated alkyl ether oils; Sphingoidoid lipids such as phytosphingosine, sphingosine and sphinginine; Cerebroside; Cytosterol; Cholesteryl sulfate; One selected from the group consisting of _cytosteryl sulfate and C _10-40 fatty alcohol. More preferably the oily component is a mixture of ceramide, cholesterol and animal and vegetable oils (jojoba oil, squalane and the like). The amount used is 1.0-30.0% by weight, preferably 3.0-20.0% by weight based on the total weight of nanoliposomes. On the other hand, the ceramides used in the present invention preferably include all kinds of ceramides of type 1-6, more preferably ceramide type 3.

Surfactants used in the preparation of the nanoliposomes of the present invention can be used in the art known in the art, for example, from the group consisting of alkylacylglutamate, alkyl phosphate, alkyl lactylate, dialkyl phosphate and trialkyl phosphate Anionic surfactant selected or a nonionic surfactant selected from the group consisting of alkoxylatedalkylether, alkoxylatedalkylester, alkylpolyglycoside, polyglyceryl ester and sugar ester, most preferably, nonionic surfactant Polysorbates belonging to the active agent are used. The amount of the surfactant to be used is generally 0.1-10% by weight, preferably 0.2-3.0% by weight based on the total weight of the nanoliposomes.

Phospholipids, another component used in the preparation of the nanoliposomes of the present invention, are used as amphoteric lipids, including natural phospholipids (eg, egg yolk lecithin or soy lecithin, sphingomyelin) and synthetic phospholipids (eg dipalmitoyl). Phosphatidylcholine or hydrogenated lecithin), preferably lecithin. More preferably, the lecithin is naturally occurring unsaturated lecithin or saturated lecithin extracted from soybean or egg yolk. Typically, lecithin derived from nature has 23-95% phosphatidyl choline and 20% or less phosphadidylethanolamine. In the preparation of the nanoliposomes of the present invention, the amount of lecithin used is 0.5-20.0% by weight, preferably 2.0-10.0% by weight, based on the total weight of the nanoliposomes.

The fatty acids used in the preparation of the nanoliposomes of the present invention are higher fatty acids, preferably saturated or unsaturated fatty acids of a C _12-22 alkyl chain, such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid. And palmilean acid, more preferably is selected from the group consisting of stearic acid, palyoleic acid and mixtures thereof. In the preparation of the nanoliposomes of the present invention, the amount of fatty acids used is 0.05-5.0% by weight, preferably 0.1-4.0% by weight relative to the total weight of nanoliposomes.

Water used for the preparation of the nanoliposomes of the present invention is generally deionized distilled water, the amount of which is used is 5.0-40% by weight relative to the total weight of nanoliposomes.

Nanoliposomes of the present invention may further comprise emollients and most preferably include caprylic / capric triglycerides. The content is 1.0-15.0 wt%, preferably 3.0-7.0 wt%. In addition, the nanoliposomes of the present invention may optionally comprise small amounts (about 0.5-1.0 wt.%) Of an emulsifier (eg, sodium stearoyl lactate).

The preparation of nanoliposomes can be accomplished through various methods known in the art, but most preferably, a mixture comprising the above components is applied to a high pressure homogenizer. The preparation of nanoliposomes by high pressure homogenizer can be carried out under various conditions (eg pressure, frequency, etc.) depending on the desired particle size, preferably 1-5 times high pressure homogenizer under 600-1200 bar pressure. Nanoliposomes are prepared by passing through.

The nanoliposome thus prepared has the advantage of maximizing the hair penetration effect of the active ingredient by stabilizing unstable substances while dissolving various kinds of poorly soluble substances.

The components included in the hair protection composition of the present invention include components commonly used in hair protection compositions, in addition to nanoliposomes stabilized by inclusion of ceramide as an active ingredient, and include, for example, stabilizers, solubilizers, vitamins, pigments and flavorings. Conventional adjuvants, and carriers.

The formulation of the composition of the present invention may be any form as long as it is applicable to hair, scalp, etc., for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing Formulated as cleansing, oil, powder foundation, emulsion foundation, wax foundation, spray, and the like.

More specifically, when the composition of the present invention is used as a composition for protecting hair, hair conditioner, hair tonic, hair cream, hair lotion, hair face, hair gel, hair pack, hair massage, hair liquid, hair spray, hair mousse, treatment , Aerosol mousse, non aerosol spray, aerosol mousse, aerosol spray, perm, bleach, shampoo, rinse, shampoo and rinse blend, soap, bar or tablet suitable for cleaning skin, soap bar, soap tablet, water dispersion It may be prepared in the form of a powder, or an oil.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, Crystalline cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The compositions of the present invention are generally used for hair or transdermal administration, such as direct application or spraying to the scalp or hair. In addition, the amount of the composition of the present invention should be appropriately determined according to individual differences such as age and degree of lesion, or the dosage form and composition of the composition.

The hair protection composition of the present invention is an essential component of ceramide, which is one of the hair structure lipids acting as an intercellular binding material, and since the ceramide, which is an active ingredient, is stabilized by being entrapped in the nanoliposome, (Ii) repairing damaged hair, (i) imparting shine and gloss of hair, (i) improving hair tensile strength, (i) imparting softness of hair and (i) combinations thereof to improve hair function and hair It exhibits the effect of protecting (see Experimental Example 1-5).

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident.

Preparation Example 1-10 Preparation of Stabilized Nanoliposomes by Inclusion of Ceramides

In order to prepare a composition for protecting hair having improved hair protection by containing ceramide as an active ingredient, ceramide was enclosed in nanoliposomes by allowing ceramide to enter the nanoliposomal membrane. Ceramide used one or more ceramides selected from the group consisting of ceramide-3, ceramide-6 and pseudoceramide. Nanoliposomes encapsulated with ceramide were prepared in the compositions of Tables 1 and 2 below. First, phase B was added to A phase and wetted uniformly, then phase C was added to AB phase and heated and mixed to 70-77 ° C. and stirred uniformly. Subsequently, the mixture was passed through a high-pressure homogenizer (Microfluidizer M-110F, Microfluidics International Corporation) 1-5 times under conditions of 600-1,200 bar and cooled to obtain nanoliposomes having a particle size of 30-70 nm in diameter (Preparation Example 1 -10) was prepared.

Prize ingredient Content (% by weight) Preparation Example 1 Preparation Example 2 Preparation Example 3 Preparation Example 4 Preparation Example 5 A glycerin 65.0 65.0 65.0 65.0 0.0 1,3-butylene glycol 0.0 0.0 0.0 0.0 0.0 Propylene glycol 0.0 0.0 0.0 0.0 60.0 B lecithin 5.0 5.0 5.0 5.0 8.0 Hydrogenated Lecithin 0.0 0.0 0.0 0.0 0.0 Ceramide 3 10.0 0.0 0.0 4.0 4.0 Ceramide 6 0.0 10.0 0.0 4.0 4.0 Pseudoceramide 0.0 0.0 10.0 2.0 2.0 Palmitic Oleic Acid 0.0 0.0 0.0 0.0 1.0 Caprylic / Capric Triglycerides 5.0 5.0 5.0 5.0 5.0 Jojoba oil 0.0 0.0 0.0 0.0 0.0 Squalane 0.0 0.0 0.0 0.0 0.0 Sodium stearoyl lactate 0.5 0.5 0.5 0.5 1.0 Polysorbate-80 0.5 0.5 0.5 0.5 0.5 C Potassium hydroxide Quantity Quantity Quantity Quantity Quantity Purified water To 100 To 100 To 100 To 100 To 100

Prize ingredient Content (% by weight) Preparation Example 6 Preparation Example 7 Preparation Example 8 Preparation Example 9 Preparation Example 10 A glycerin 30.0 60.0 60.0 60.0 60.0 1,3-butylene glycol 40.0 0.0 0.0 0.0 0.0 Propylene glycol 0.0 0.0 0.0 0.0 0.0 B lecithin 0.0 0.0 6.0 3.0 3.0 Hydrogenated Lecithin 8.0 8.0 0.0 3.0 3.0 Ceramide 3 4.0 4.0 4.0 4.0 4.0 Ceramide 6 4.0 4.0 4.0 4.0 4.0 Pseudoceramide 2.0 2.0 2.0 2.0 2.0 Palmitic Oleic Acid 2.0 0.0 0.0 1.0 2.0 Caprylic / Capric Triglycerides 0.0 5.0 5.0 5.0 8.0 Jojoba oil 3.0 0.0 5.0 0.0 0.0 Squalane 0.0 5.0 0.0 0.0 0.0 Sodium stearoyl lactate 0.5 0.5 1.0 0.0 0.5 Polysorbate-80 0.0 0.5 0.0 1.0 0.5 C Potassium hydroxide Quantity Quantity Quantity Quantity Quantity Purified water To 100 To 100 To 100 To 100 To 100

Examples and Comparative Examples: Preparation of Hair Composition

In order to investigate the effect of ceramide, one of the hair structure lipids acting as intercellular binding materials, on the nanoliposomes and to stabilize the hair, a composition of a rinse formulation containing ceramide and nanoliposomes was prepared. To the composition shown in Table 3, containing a composition containing nano-liposomes incorporating ceramide (Example), a composition containing only ceramide (Comparative Example 1) and a composition not containing both ceramide and nanoliposomes (Comparative Example 2) Prepared.

The nanoliposomes used in the preparation of the hair composition of Example were used nanoliposomes encapsulated with the ceramide of Preparation Example 4, and ceramide 3 was used as the ceramides used in the preparation of Comparative Example 1.

ingredient Example Comparative Example 1 Comparative Example 2 Content (% by weight) Content (% by weight) Content (% by weight) Ceramide Entrapped Nanoliposomes 10.0 - - Ceramide - 1.0 - Distearyl Dimethyl Ammonium Chloride 2.5 2.5 2.5 Methyl paraoxybenzoate 0.1 0.1 0.1 Cetostearyl alcohol 3.0 3.0 3.0 Hydroxyethyl cellulose 0.7 0.7 0.7 Polyquaternium-10 0.2 0.2 0.2 Glycerin Monostearate 1.0 1.0 1.0 BHT 0.01 0.01 0.01 EDTA-2Na 0.01 0.01 0.01 Spices a very small amount a very small amount a very small amount Purified water to 100 to 100 to 100

Experimental Example 1: Measurement of the stability of the formulation

The stability test for the composition containing nanoliposomes stabilized by inclusion of ceramide, one of the hair structure lipids, was carried out by the following method.

In order to test the stability of the formulation, the rinses of Examples and Comparative Examples 1 and 2 prepared above were kept in an opaque glass container for 12 weeks in a constant temperature bath maintained at 45 ° C., and kept constant at 4 ° C. The degree of recrystallization was measured after storing for 12 weeks in an opaque glass jar in a fully shielded refrigerator. The results are summarized in Table 4 below. At this time, the degree of product crystallization was evaluated by classifying into the following six grades.

<Production degree of crystallization>

0: no change, 1: very little crystallization,

2: little crystallization, 3: little crystallization,

4: severely crystallized, 5: extremely heavily crystallized.

Temperature Degree of crystallization Example Comparative Example 1 Comparative Example 2 45 ℃ 0 1.3 0 Room temperature 0 2.4 0 4 ℃ 0 4.5 0

As can be seen from Table 3, Comparative Example 1 used directly in the formulation without stabilizing the ceramide crystallization of the ceramide occurs at all temperature conditions, especially at low temperatures it was found that the formulation itself is unstable because it is more severe . However, the rinse of the example in which the ceramide was included and stabilized with nanoliposomes was stable without crystallization under all temperature conditions.

Experimental Example 2: Experiment for Restoring Damaged Hair

Using the hair compositions of Examples and Comparative Examples 1 and 2, the recovery effect of the damaged hair was examined. Ten male and female volunteers with minor hair damage were selected as the test subjects. Before the experiment, the hair was triturated using a normal shampoo without rinse function. After shampooing the hair, the hair compositions of Examples and Comparative Examples 1 and 2 were massaged into the hair for about 3 minutes, rinsed with lukewarm water for 1 minute, and then dried with a dryer to completely dry the hair. After shampooing (0 days), massage after drying 1 hour after drying (1 hour), 3 days after (3 days), 5 days after (5 days) Therefore, the recovery effect on the damaged hair was evaluated. The results are shown in Table 5 below.

<Recovery Effect Rating for Damaged Hair>

0: rough damage, 1: slight damage, 2: normal, 3: good, 4: best

Treatment condition Recovery Effect (Male) Recovery Effect (Female) Average One 2 3 4 5 6 7 8 9 10 One 2 3 4 5 6 7 8 9 10 Example 0 days One One One One 0 One 0 One One One 0 0 One One 0 One One One 0 One 0.7 1 hours 3 3 4 2 3 4 3 3 2 3 2 3 4 4 3 4 3 3 3 4 3.2 3 days 3 3 3 2 2 3 3 2 2 3 2 3 3 3 3 4 2 3 3 3 2.8 5 days 2 3 2 2 2 2 3 2 2 2 2 3 2 2 3 3 2 3 2 3 2.4 Comparative Example 1 0 days 0 One One One One 0 0 One One One One 0 One One One One One 0 One One 0.8 1 hours 3 3 2 3 4 2 3 3 2 2 2 3 2 2 3 3 2 2 3 4 2.7 3 days 2 2 2 2 3 One 3 3 2 2 2 2 One 2 2 2 One 2 2 2 2.0 5 days 2 One 2 One 2 One 2 2 2 One 2 One One One 2 One One One 2 One 1.6 Comparative Example 2 0 days 0 0 One One One 0 One One One One 0 0 One One 0 One One One One 0 0.7 1 hours One One One 2 One One One One 2 One One 0 2 One One One One 2 One One 1.4 3 days 0 One One One One One One One One One One 0 2 One One One One 2 One One 1.0 5 days 0 0 One One One One One One One One 0 0 One One One One One One One One 0.8

Based on the results of Table 5, the rinse of the example containing nanoliposomes stabilized by inclusion of ceramide was compared to the rinse of Comparative Example 1 containing only ceramide and the rinse of Comparative Example 2 not containing all of the above components. The recovery effect was very good.

Experimental Example 3: Hair Gloss and Gloss Test

In order to determine the degree of gloss and gloss of each of the compositions of Examples and Comparative Examples 1 and 2, 10 female volunteers were selected for the 20-30 year old. Before the experiment, the hair was triturated using a normal shampoo without rinse function. After shampooing the hair, the hair compositions of Examples and Comparative Examples 1 and 2 were massaged into the hair for about 3 minutes, rinsed with lukewarm water for 1 minute, and then dried with a dryer to completely dry the hair. After shampooing (0 days) before massage with the composition, after drying after 1 hour (1 hour), after 3 days (3 days) the shine and gloss was evaluated by rating as follows. The results are shown in Table 6 below.

<Grade for Gloss and Gloss>

0: very bad, 1: bad, 2: normal, 3: good, 4: very good

Treatment condition Shiny and Glossy (Female) Average One 2 3 4 5 6 7 8 9 10 Example 0 days One One 2 One 2 2 0 One One 2 1.3 1 hours 4 3 4 3 3 3 3 4 3 4 3.4 3 days 3 2 3 3 3 3 3 4 3 3 3.0 Comparative Example 1 0 days 2 One 0 One One One 2 0 One 2 1.1 1 hours 3 3 2 3 4 3 3 One 3 3 2.8 3 days 2 2 2 3 3 2 2 One 2 2 2.1 Comparative Example 2 0 days One 2 2 2 0 One One 2 One 0 1.2 1 hours One 2 3 2 One One One 2 2 One 1.6 3 days One 2 2 2 One One One 2 One One 1.4

Looking at the results of Table 6, the rinse of the example containing nano-liposomes stabilized by inclusion of ceramide hair shine and hair shine compared to the rinse of Comparative Example 1 containing only ceramide and Comparative Example 2 not containing all of the components The degree of gloss enhancement was much increased. Therefore, the hair composition of the present invention can be seen that the hair shine and gloss enhancement effect is excellent.

Experimental Example 4: Hair Tensile Strength

Ten female volunteers who participated in the experiment of Experimental Example 3 measured the tensile strength (N (Newton) / ㎠) of the hair using the NIS TRONG (Switzerland) equipment during the test period. The measured tensile strength results are shown in Table 7 below, where the figures are the average of the hair tensile strength for 5 ol per volunteer.

Processing conditions Hair Tensile Strength (N / ㎠) Average One 2 3 4 5 6 7 8 9 10 Example 0 days 11 12 14 12 13 13 11 12 11 13 12.2 1 hours 13 14 15 14 15 14 13 15 13 15 14.1 3 days 14 15 16 13 16 16 14 16 15 16 15.1 Comparative Example 1 0 days 12 11 13 13 12 11 12 14 13 13 12.4 1 hours 13 13 13 14 14 13 15 15 14 13 13.7 3 days 14 13 13 14 15 14 15 15 15 14 14.2 Comparative Example 2 0 days 11 12 12 13 12 12 12 13 13 12 12.2 1 hours 11 12 13 13 12 13 12 13 13 13 12.5 3 days 11 12 14 13 12 13 13 13 13 13 12.7

Given that the tensile strength of normal hair is usually known to be 13-16 N / cm 2, from the results of Table 7, the rinse composition of the example containing the nanoliposomes stabilized by inclusion of ceramide is a comparative example containing only ceramide. The tensile strength of the hair was much increased compared to the rinse of Comparative Example 2, which did not include both 1 and the above components. Therefore, the effect of increasing the tensile strength of the hair by the hair composition of the present invention is judged as a result of restoring damaged hair and preventing hair damage.

Experimental Example 5: Evaluation of Combing Ease in Wet Hair

In order to check whether the hair composition of the present invention, which is stabilized by inclusion of ceramide in nanoliposomes, imparts softness to the hair, after applying the compositions of Examples and Comparative Examples 1 and 2 to the hair, the ease of combing in wet hair Evaluated. After 5 g of the hair bundle was triturated with a general shampoo without a rinse function, the compositions of Examples and Comparative Examples 1 and 2 were taken, massaged for 2 minutes and 30 seconds, respectively, and washed with lukewarm water. After combing the excess moisture from the hair, combing with a constant force to free, gently combing the number of combing to the composition five times in a uniform method was obtained by the average to evaluate the ease of combing in wet hair . As a control example, the number of combs for the same hair after shampooing was evaluated for the same hair before massage with the compositions of Examples and Comparative Examples 1 and 2. The results are as described in Table 8 below.

Treatment condition Combs (times) Example 6-7 Comparative Example 1 8-9 Comparative Example 2 11-12 Control 13-14

As shown in Table 8, before applying the composition (control) after the number of combs 13-14 times after applying the composition of the present invention (Example) containing nanoliposomes stabilized by inclusion of ceramide Appeared 6-7 times it was found that the ease of combing is increased by the composition of the present invention. In addition, the number of combing of the composition of the present invention was much less than in Comparative Examples 1 and 2. Therefore, it was found that by applying the composition of the present invention to the hair, the hair was softened and the combing became easy.

Hereinafter, based on the results of the above experimental example, a hair protection composition containing nanoliposomes stabilized by inclusion of ceramide, one of hair structural lipids serving as intercellular binding substances, is presented. However, the hair protection composition of the present invention is not limited to the following formulation examples.

Formulation Example 1: Shampoo

Shampoo was prepared according to a conventional method as shown in Table 9 below.

Compounding ingredients Content (% by weight) Nanoliposomes stabilized by inclusion of ceramide (Production Example 4) 3.0 Ammonium Lauryl Sulfate 10.0 Polyoxyethylene lauryl ammonium sulfate 5.0 Coco Amido Profile Betaine 3.0 Ethylene Glycol Distearate 1.0 Polyquaternium-7 0.1 Distearyl dimethyl ammonium chloride 0.5 Methyl paraoxybenzoate 0.1 Citric acid 1.0 Spices a very small amount Purified water to 100

Formulation Example 2. Rinse

Rinse was prepared according to a conventional method as shown in Table 10 below.

Compounding ingredient Content (% by weight) Nanoliposomes stabilized by inclusion of ceramide (Production Example 4) 5.0 Distearyl Dimethyl Ammonium Chloride 2.5 Methyl paraoxybenzoate 0.1 Cetostearyl alcohol 3.0 Hydroxyethyl cellulose 0.7 Polyquaternium-10 0.2 Glycerin Monostearate 1.0 BHT 0.01 EDTA-2Na 0.01 Spices a very small amount Purified water to 100

As described above in detail, the present invention provides a composition for protecting hair containing nanoliposomes stabilized by inclusion of ceramide as an active ingredient. The composition of the present invention is made by encapsulating and stabilizing ceramide, one of the hair structure lipids, which act as an intercellular binding material, to nanoliposomes, thereby restoring damaged hair by facilitating hair penetration of the ceramide component, and improving hair shine and gloss. It is very useful for improving hair function and protecting hair because it has an excellent effect of increasing hair tensile strength and softening hair.

Having described the specific part of the present invention in detail, it is apparent to those skilled in the art that the specific technology is merely a preferred embodiment, and the scope of the present invention is not limited thereto. Accordingly, the substantial scope of the present invention will be defined by the appended claims and equivalents thereof.

Claims (13)

A composition for protecting hair comprising nanoliposomes stabilized by inclusion of ceramide as an active ingredient, wherein the nanoliposomes are oily components including (i) polyols, (ii) ceramides and cholesterol, (i) surfactants, and (i) phospholipids. And (iii) a fatty acid and (iii) water, wherein the mixture does not contain monohydric alcohol, and the content of ceramide is based on the total weight of the nanoliposome. It is 10.0-30.0 weight% with respect to the hair protection composition. The composition of claim 1, wherein the composition comprises (i) imparting stability of the formulation, (ii) restoring damaged hair, (i) imparting gloss and gloss of hair, (i) improving hair tensile strength, and (i) softening hair. A composition for protecting hair, comprising the action of imparting or (iv) a combination thereof. According to claim 1, wherein the content of the nano-liposomes hair protection composition, characterized in that 0.1 to 20.0% by weight based on the total weight of the composition. delete delete The method of claim 1, wherein the polyol is selected from the group consisting of propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, methylpropanediol, isoprene glycol, pentylene glycol, erythritol, xyitol and sorbitol Content is a hair protective composition, characterized in that 10.0-80.0% by weight relative to the total weight of the nano liposomes. The oil-based component according to claim 1, wherein the oil component is hydrocarbon oil, ester oil, silicone oil, animal or vegetable oil, ethoxylated alkyl ether oil, propoxylated alkyl ether oil, in addition to ceramide and cholesterol. , And further selected from the group consisting of sphingoidoid lipids, cerebroside, cytosterol, cholesteryl sulfate, cytosteryl sulfate, C _10-40 fatty alcohol and mixtures thereof, the content of which is added to the total weight of nanoliposomes 1.0-30.0% by weight relative to the composition for hair protection. The method of claim 1, wherein the surfactant is an anionic surfactant or alkoxylated alkyl ether, alkoxylated alkyl ester selected from the group consisting of alkylacyl glutamate, alkyl phosphate, alkyl lactylate, dialkyl phosphate and trialkyl phosphate, A nonionic surfactant selected from the group consisting of alkyl polyglycosides, polyglyceryl esters and sugar esters, the content of which is 0.1-10.0% by weight relative to the total weight of nanoliposomes. The method of claim 1, wherein the phospholipid is lecithin, the content of the hair protective composition, characterized in that 0.5-20.0% by weight relative to the total weight of the nanoliposomes. The method of claim 1, wherein the fatty acid is a saturated or unsaturated fatty acid of the C _12-22 alkyl chain, the content of the hair protection composition, characterized in that 0.05 to 5.0% by weight relative to the total weight of the nanoliposomes. The method of claim 1, wherein the water is deionized distilled water, the content of the hair protective composition, characterized in that 5.0 to 40.0% by weight relative to the total weight of the nano liposomes. The method of claim 1, wherein the nanoliposomes are hair protection composition, characterized in that the mixture is prepared by applying a high pressure homogenizer. The composition of claim 1, wherein the composition is a hair conditioner, hair tonic, hair cream, hair lotion, hair face, hair gel, hair pack, hair massager, hair liquid, hair spray, hair mousse, treatment, non aerosol mousse, b. Aerosol spray, aerosol mousse, aerosol spray, perm, bleach, shampoo, rinse, shampoo and rinse blend, soap, bar or tablet suitable for cleaning skin, soap bar, soap tablet, water dispersion, powder and oil Hair protection composition, characterized in that it has a formulation selected from.