KR102236418B1 - Cosmetic composition containing ceramide having a refreshing sensation - Google Patents

Abstract

It relates to a moisturizing cosmetic composition containing ceramide having a refreshing sensation, and the cosmetic composition according to an aspect provides a refreshing sensation to the skin even though it contains a high content of ceramide through adjusting the water part content without applying a separate cooling agent. By controlling the content of the polymer, it is possible to achieve a sorbet-like appearance suitable for providing a refreshing moisture sensation.

Description

Cosmetic composition containing ceramide having a refreshing sensation}

It relates to a moisturizing cosmetic composition containing ceramide having a refreshing feeling.

Since makeup actually gives the skin a hot feeling, it is common to apply an additive such as menthol or an alcohol component such as volatile ethanol in order to give the skin a refreshing sensation. In the case of menthol, it directly acts on the cooling receptors of the skin nerves, and then stimulates the central nervous system to feel a feeling of cooling. However, menthol or menthol derivatives have a strong odor and are relatively volatile, so their use is limited. In the case of general volatile ingredients, especially ethanol, which is highly volatile, it is possible to feel an immediate refreshing sensation, but the duration is short and may cause irritation and dryness of the skin.

Therefore, there is a need for a moisturizing cosmetic composition having a hypoallergenic refreshing sensation that overcomes the problems of conventional irritation and strong volatility. As a moisturizing cosmetic, the development of cosmetic products to contain high content of natural moisturizing factors (NFM) such as ceramide, which is a very important component of the outer skin among the epidermis and is known to have moisture retention ability of the skin, is increasing. (Korean Patent Registration 10-0837558).

On the other hand, in the case of a formulation containing ceramide, a phenomenon such as an increase in hardness or agglomeration of the formulation generally occurs due to the characteristics of ceramide. Therefore, in order to stably apply ceramide, oils of a certain amount or more must be included.Therefore, the higher the content of ceramide, the more nutritious there is.Therefore, it has been difficult to apply a high content of ceramide to the type of formulation with a refreshing hydration.

One aspect is to provide a skin moisturizing cosmetic composition comprising 0.3 to 1.2% by weight of a thickener, 0.1 to 1.5% by weight of a lecithin-treated ceramide mixture, and 1.0 to 15.0% by weight of a polyol moisturizing component.

Another aspect is to provide a skin moisturizing composition for external application for skin comprising 0.3 to 1.2% by weight of a thickener, 0.1 to 1.5% by weight of a lecithin-treated ceramide mixture, and 1.0 to 15.0% by weight of a polyol moisturizing component.

One aspect provides a skin moisturizing cosmetic composition comprising 0.3 to 1.2% by weight of a thickener, 0.1 to 1.5% by weight of a lecithin-treated ceramide mixture, and 1.0 to 15.0% by weight of a polyol moisturizing component.

The term "thickener" as used herein refers to a material that increases the viscosity of a solution, and may be used to obtain a gel-type formulation, and specifically, may be a polymer. In one embodiment, the thickener may be sodium acrylate crosspolymer-2.

The thickener is 0.3 to 1.2% by weight based on the total weight of the composition, for example, 0.3 to 1.0% by weight, 0.3 to 0.8% by weight, 0.3 to 0.7% by weight, 0.3 to 0.6% by weight, 0.3 to 0.5% by weight, 0.4 To 1.2 wt%, 0.4 to 1.0 wt%, 0.4 to 0.8 wt%, 0.4 to 0.7 wt%, 0.4 to 0.6 wt%, 0.5 to 1.2 wt%, 0.5 to 1.0 wt%, 0.5 to 0.8 wt%, 0.5 to 0.7 It may be weight %, 0.6 to 1.2 weight %, 0.6 to 1.0 weight %, 0.6 to 0.8 weight %, 0.7 to 1.2 weight %, or 0.7 to 1.0 weight %. When the thickener is 0.1% by weight or less based on the total weight of the composition, a liquid composition with no gel formation and little turbidity can be obtained, and when it is 1.5% by weight or more, a gel is formed but the thickener component in the formulation is uniformly Clumping may occur without stirring.

The term "lecithin" as used herein refers to an intercellular phospholipid as a major component constituting a biological membrane, and may be used to stably contain ceramide. Specifically, it may be hydrogenated lecithin, and the "hydrogenated lecithin" may mean that hydrogen is added to lecithin to prevent the lecithin from becoming unstable when contacted with oxygen.

The term “treatment” as used herein may mean a method of stabilizing ceramide, specifically, an arbitrary method for increasing the solubility of ceramide so that ceramide is not precipitated.

The term “ceramide” as used herein is a major component constituting the stratum corneum of the skin, and is an intercellular lipid that fills between keratinocytes, and may mean a component essential for showing the structure or function of the stratum corneum. In addition, since the ceramide has a role of a lipid barrier that inhibits evaporation of moisture and a function of maintaining the orderly structure of the stratum corneum, it may be helpful in wound healing and skin regeneration by rapidly recovering the damaged skin barrier. As the content of the ceramide increases, the skin moisturizing effect increases, and the skin texture may become even or softer. In order to apply the ceramide in a high content, it must be able to stably contain ceramide, and when the lecithin is treated, the ceramide may be stabilized and dissolved in the formulation without being precipitated. The ceramide may include not only natural ceramide, but also a substance that acts as a skin barrier such as natural ceramide as a similar ceramide.

The “high content” may mean that the ceramide is not precipitated in the formulation and contains ceramide as much as possible within a range capable of providing a refreshing feeling while maintaining a homogeneous gel cream form.

The "lecithin-treated ceramide mixture" is 0.1 to 1.5% by weight, for example, 0.1 to 1.2% by weight, 0.1 to 0.9% by weight, 0.1 to 0.6% by weight, 0.1 to 0.3% by weight, 0.4 to 1.5% by weight, 0.4 to 1.2% by weight, 0.4 to 0.9% by weight, 0.4 to 0.6% by weight, 0.7 to 1.5% by weight, 0.7 to 1.2% by weight, 0.7 to 0.9% by weight, 1.0 to 1.5% by weight, 1.0 to 1.2% by weight %, or 1.3 to 1.5% by weight.

In one embodiment, the lecithin-treated ceramide mixture may include hydrogenated lecithin, ceramide NP, sucrose stearate, stearic acid, palmitic acid, cholesterol, and glycosphingolipid.

The term “polyol moisturizing component” used herein is one of the components constituting the water phase, and is not used as a separate cooling agent, but may contribute to reducing skin temperature.

The "separate cooling agent" may mean an additive such as menthol or an alcohol component such as volatile ethanol that is separately added to give a refreshing feeling to the skin. The separate cooling agent may have a strong odor or strong volatility to cause irritation or dry skin.

The polyol moisturizing component is 1.0 to 15.0 wt%, for example, 1.0 to 12.0 wt%, 1.0 to 9.0 wt%, 1.0 to 6.0 wt%, 1.0 to 3.0 wt%, 4.0 to 15.0 wt%, based on the total weight of the composition, 4.0 to 12.0 wt%, 4.0 to 9.0 wt%, 4.0 to 6.0 wt%, 7.0 to 15.0 wt%, 7.0 to 12.0 wt%, 7.0 to 9.0 wt%, 10.0 to 15.0 wt%, 10.0 to 12.0 wt%, or 13.0 To 15.0% by weight. When the polyol moisturizing component is 20.0% by weight or more based on the total weight of the composition, the effect of reducing skin temperature and sustaining the skin moisturizing effect may be lowered.

In one embodiment, the polyol moisturizing component may be at least one selected from the group consisting of glycerin, butylene glycol, dipropylene glycol, propanediol, glyceres-26, and diglycerin.

The cosmetic composition may be selected from 0.3 to 1.2% by weight of a thickener, 0.1 to 1.5% by weight of a lecithin-treated ceramide mixture, and 1.0 to 15.0% by weight of a polyol moisturizing component to suit the purpose and formulation.

The term “skin moisturizing” as used herein may mean any action of maintaining skin moisture or preventing moisture loss.

In one embodiment, the composition may be to impart a refreshing sensation to the skin. The term "refreshing sensation" as used herein may mean an effect of reducing the skin temperature elevated by heat, and the composition according to an embodiment may represent a refreshing sensation by adjusting the content of the water phase.

In one embodiment, the composition is a lotion (skin lotion), skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nourishing lotion, massage cream, nourishing cream, moisturizing cream, eye cream, hand cream, foundation , Essence, nutrition essence, eye essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cream, body cleanser, suspension, gel, powder, paste, mask pack, or formulation containing a sheet or aerosol composition It can be manufactured with. In addition, it can be applied in a variety of properties suitable for providing a refreshing moisture sensation to the skin, such as a gel or cream form, a paste form, and a solid state, and specifically, may be a gel cream form having a particle sensation such as sorbet or slush. Compositions of these formulations can be prepared according to methods conventional in the art. In one embodiment, the composition may further include one or more selected from the group consisting of oils, purified water, emulsifiers, dispersants, pigments, fragrances, sunscreens, sweeteners, vitamins, and sequestering agents. In addition, in one embodiment, the composition may further contain 0.1 to 3.0% by weight of a preservative. The blending amount of the additional components such as oils can be easily selected by a person skilled in the art within a range that does not impair the object and effect of the present invention.

Another aspect provides a skin moisturizing composition for external application for skin comprising 0.3 to 1.2% by weight of a thickener, 0.1 to 1.5% by weight of a lecithin-treated ceramide mixture, and 1.0 to 15.0% by weight of a polyol moisturizing component.

In the composition for external application for skin, the thickener, lecithin, treatment, ceramide, lecithin-treated ceramide mixture, polyol moisturizing component, skin moisturizing, and the like are as described above.

The “skin external preparation” may be for preventing or treating diseases caused by impaired skin barrier function. The damage to the skin barrier function may mean all changes that appear on the skin due to a decrease or damage to the function of the skin barrier. For example, it may include increased skin wrinkles, dryness, dermatitis, atopic dermatitis, allergic dermatitis, acne, and the like. The “prevention” may include suppressing the occurrence of the disease, and the “treatment” may include suppressing, alleviating, or eliminating the development of the disease. In addition, the external preparation for skin is fatty substances, organic solvents, solubilizers, thickening and gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic or nonionic Emulsifiers, fillers, sequestering and chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles, or any other ingredients commonly used in external preparations for skin It may further include an adjuvant commonly used in the same dermatological field. Their amounts can be appropriately determined by a person skilled in the art.

The cosmetic composition according to an aspect imparts a refreshing sensation to the skin even though it contains a high content of ceramide through controlling the content of the aqueous phase without applying a separate cooling agent having an irritation or a specific odor. In addition, by controlling the content of a specific polymer, it is possible to implement a sorbet-like appearance suitable for providing a refreshing moisture sensation, and there is no increase in hardness or agglomeration of the formulation, so it is possible to continuously maintain the same appearance and feeling of use.

1 is a photograph showing the appearance of the formulation of Example 1.
2 is a photograph showing the appearance of the formulations of Comparative Examples 1 to 3 from the left.

Hereinafter, the present invention will be described in more detail through examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples.

Example 1. Preparation of lecithin-treated ceramide-containing gel cream

A mixture of citric acid, 1,2-hexanediol, glycerin, and lecithin-treated ceramide in purified water was weighed in a beaker and then heated to 35-40°C. This was uniformly dispersed for 5 minutes at 3000 rpm using a stirrer (HOMO), and then sodium polyacrylate crosspolymer-2 was added and stirred at the same speed for 5 minutes. Thereafter, preservatives, fragrances, and pigments were added and stirred at 2500 rpm for 3 minutes to prepare a cosmetic composition in the form of a gel cream.

Comparative Example 1. Preparation of a cosmetic composition containing ceramide not treated with lecithin

Citric acid, 1,2-hexanediol, and glycerin were weighed in purified water in a beaker and then heated to 75-80°C. This was uniformly dispersed for 5 minutes at 3000 rpm using a stirrer (HOMO), and then sodium polyacrylate crosspolymer-2 and ceramide NP were heated and added, followed by stirring at the same speed for 5 minutes. After that, preservatives, fragrances, and pigments were added and stirred at 2500 rpm for 3 minutes to prepare a cosmetic composition.

Comparative Example 2. Preparation of a cosmetic composition containing lecithin-treated ceramide containing a small amount of a thickener

A mixture of citric acid, 1,2-hexanediol, glycerin, and lecithin-treated ceramide in purified water was weighed in a beaker and then heated to 35-40°C. This was uniformly dispersed for 5 minutes at 3000 rpm using a stirrer (HOMO), and then sodium polyacrylate crosspolymer-2 was added and stirred at the same speed for 5 minutes. Thereafter, preservatives, fragrances, and pigments were added and stirred at 2500 rpm for 3 minutes to prepare a cosmetic composition in the form of a gel cream.

Comparative Example 3. Preparation of a cosmetic composition containing lecithin-treated ceramide containing an excessive amount of a thickener.

A mixture of citric acid, 1,2-hexanediol, glycerin, and lecithin-treated ceramide in purified water was weighed in a beaker and then heated to 35-40°C. This was uniformly dispersed for 5 minutes at 3000 rpm using a stirrer (HOMO), and then sodium polyacrylate crosspolymer-2 was added and stirred at the same speed for 5 minutes. Thereafter, preservatives, fragrances, and pigments were added and stirred at 2500 rpm for 3 minutes to prepare a cosmetic composition in the form of a gel cream.

Comparative Example 4. Preparation of gel cream containing no ceramide

Citric acid, 1,2-hexanediol, and glycerin were weighed in purified water in a beaker and then heated to 35-40°C. This was uniformly dispersed for 5 minutes at 3000 rpm using a stirrer (HOMO), and then sodium polyacrylate crosspolymer-2 was added and stirred at the same speed for 5 minutes. After that, preservatives, fragrances, and pigments were added and stirred at 2500 rpm for 3 minutes to prepare a cosmetic composition.

Comparative Example 5. Preparation of gel cream containing lecithin-treated ceramide containing an excess of polyol moisturizing component

A mixture of citric acid, 1,2-hexanediol, glycerin, and lecithin-treated ceramide in purified water was weighed in a beaker and then heated to 35-40°C. This was uniformly dispersed for 5 minutes at 3000 rpm using a stirrer (HOMO), and then sodium polyacrylate crosspolymer-2 was added and stirred at the same speed for 5 minutes. Thereafter, preservatives, fragrances, and pigments were added and stirred at 2500 rpm for 3 minutes to prepare a cosmetic composition in the form of a gel cream.

The following [Table 1] shows the specific components and contents of the cosmetic compositions of Example 1 and Comparative Examples 1 to 5.

Experimental Example 1. Confirmation of gel cream formation and homogeneity

In order to confirm whether the cosmetic composition of Example 1 and Comparative Examples 1 to 5 was formed in a gel cream form or to confirm the homogeneity and feeling of use of the gel cream, the appearance of the formulation was compared and observed. 1 is a photograph showing the appearance of the formulation of Example 1. 2 is a photograph showing the appearance of the formulations of Comparative Examples 1 to 3 from the left.

As a result, as shown in FIG. 1, in the case of Example 1, Comparative Example 4, and Comparative Example 5, it was confirmed that a composition in the form of a gel cream having a murky particle feeling was obtained. On the other hand, as shown in FIG. 2, in the case of Comparative Example 1 containing ceramide that was not treated with lecithin, crystalline ceramide was not properly dissolved in the formulation and precipitated, and in Comparative Example 2, the gel was not formed and the turbidity was Little liquid composition was obtained. In addition, in the case of Comparative Example 3, a composition in the form of a gel cream was obtained, but the thickener component in the formulation was not uniformly agitated but agglomerated in several places, and when applied to the skin, the thickener was lumped and pushed. Was confirmed.

This means that the cosmetic compositions prepared in Example 1, Comparative Example 4, and Comparative Example 5 have a mixing ratio capable of implementing a suitable feeling of use and gel properties as a cream. Specifically, in order to obtain a homogeneous formulation without clumping while the gel cream is formed, a thickener should be contained in an amount greater than 0.1% by weight and less than 1.5% by weight based on the total weight of the composition, and ceramide is stable in a formulation that does not contain an oily component. It can be seen that lecithin must be contained in order to contain as.

Experimental Example 2. Checking the effect of reducing skin temperature

In order to confirm the effect of reducing skin temperature (refreshing sensation) for Example 1, Comparative Example 4, and Comparative Example 5 obtained as a composition in the form of a gel cream, changes in skin temperature after application of the product after heating were measured. The skin temperature of 20 women aged 20 to 55 years old before and after heating, and after applying each product once, was measured using a thermal imaging camera (T-250). For the analysis, the average value of the skin temperature of each of the product-applied and non-applied areas was used as evaluation data. The unit is the unit constant ℃, and the skin temperature and the measured value are proportional.

The following [Table 2] shows the results of measuring changes in skin temperature after one application of Example 1, Comparative Example 4, and Comparative Example 5 after heating.

As a result, as shown in Table 2, in all of Example 1, Comparative Example 4, and Comparative Example 5, the skin temperature significantly decreased after application of the product compared to after heating, but Comparative Example 5 having a relatively high polyol moisturizing component content. In, the effect of reducing skin temperature was insignificant. On the other hand, in Example 1 and Comparative Example 4, in which the content of the polyol moisturizing component was not high, the skin temperature reduction range was large, and it was confirmed that the skin temperature reduction effect was the greatest in Example 1.

This means that the content of the polyol moisturizing component must be adjusted to less than 20% by weight based on the total weight of the composition in order to provide a refreshing feeling to the skin while containing the moisturizing component ceramide. Therefore, it can be seen that even without a separate cooling agent such as menthol or alcohol having irritation or strong volatility, the effect of significantly reducing skin temperature can be obtained only by controlling the content of the aqueous phase.

Experimental Example 3. Confirmation of skin moisturizing effect

In order to confirm the skin moisturizing effect for Example 1, Comparative Example 4, and Comparative Example 5 obtained as a composition in the form of a gel cream, changes in skin moisture level over time after application of the product were measured. Skin moisture levels were measured before, immediately after, and over time in 5 adult females with an average age of 28.2 years using a Corneometer. Specifically, 30 minutes before the test, the test site was washed with lukewarm water, and after waiting for 10 minutes in a constant temperature and humidity room (22 ± 2°C, 40 to 60%RH), the skin moisture level when the test site was not applied was measured. In addition, after applying the test product to the test site, the skin moisture level was measured immediately after application of the product, after 2 hours, and after 8 hours. The unit is A.U., which is a unit constant, and the amount of skin moisture and the measured value are proportional. The measured values represent the average of three times.

[Table 3] shows the results of measuring skin moisture levels before, immediately after, 2 hours, and 8 hours after application of Example 1, Comparative Example 4, and Comparative Example 5.

As a result, as shown in Table 3, the skin moisture level immediately after application was increased compared to before application in Example 1, Comparative Example 4, and Comparative Example 5, but Comparative Example 4 that did not contain ceramide, which is known to be effective in moisturizing. In, no moisturizing effect was observed after 2 hours of application. On the other hand, in Example 1 and Comparative Example 5 containing ceramide, it was confirmed that the skin moisture level remained high even after 8 hours of application. In particular, the skin moisture content of Comparative Example 5 having a high polyol moisturizing component content immediately after application was higher than that of Example 1 in which the polyol moisturizing component content was not high, but after 8 hours of application, the skin moisture level of Example 1 was maintained higher. Became.

This means that the moisturizing effect of ceramide is excellent, and the moisturizing effect by the polyol moisturizing component means that the moisturizing effect of the polyol does not play a big role in maintaining skin moisture other than the immediate moisturizing effect. Therefore, it can be seen that if the ceramide is contained in a high content and the polyol moisturizing component is adjusted to less than 20% by weight based on the total weight of the composition, the moisturizing effect persistence can be improved.

Experimental Example 4. Sensory test against skin irritation

In order to confirm the degree of skin irritation for Example 1, Comparative Example 4, and Comparative Example 5 obtained as a composition in the form of a gel cream, sensory evaluation was performed. Ten adult women were subjected to continuous use of each product at least once per person for 2 weeks, and then phenomena such as itching, itchiness, and erythema were evaluated. Evaluation was performed based on the criteria of very good (5 points), excellent (4 points), fair (3 points), bad (2 points), and very bad (1 point).

The following [Table 4] is a result showing the evaluation of skin irritation of Example 1, Comparative Example 4, and Comparative Example 5.

As a result, as shown in Table 4, it was confirmed that Example 1 containing ceramide and an appropriate amount of the polyol moisturizing component had a low degree of skin irritation at a level equal to or higher than that of Comparative Example 4 and Comparative Example 5, and thus excellent skin stability. .

This is a result of the fact that a separate cooling agent that causes skin irritation such as menthol or alcohol is not included, and when ceramide having a good moisturizing effect is contained, it is recommended to contain less than 20% by weight of a polyol moisturizing component based on the total weight of the composition. This means that the degree of skin irritation is lower.

Claims (8)

A cosmetic composition for moisturizing skin on a gel cream comprising 0.3 to 1.2% by weight of a thickener, 0.1 to 1.5% by weight of a lecithin-treated ceramide mixture, and 1.0 to 12.0% by weight of a polyol moisturizing component.
The composition of claim 1, wherein the thickener is sodium acrylate crosspolymer-2.
The composition of claim 1, wherein the lecithin-treated ceramide mixture comprises hydrogenated lecithin, ceramide NP, sucrose stearate, stearic acid, palmitic acid, cholesterol, and glycosphingolipid.
The composition of claim 1, wherein the polyol moisturizing component is at least one selected from the group consisting of glycerin, butylene glycol, dipropylene glycol, propanediol, glyceres-26, and diglycerin.
The composition of claim 1, wherein the composition imparts a refreshing feeling to the skin.
The composition of claim 1, wherein the composition further comprises 0.1 to 3.0% by weight of a preservative.
The composition of claim 1, wherein the composition further comprises at least one selected from the group consisting of oils, purified water, emulsifiers, dispersants, pigments, flavors, sunscreens, sweeteners, vitamins, and sequestering agents.
As a skin external pharmaceutical composition for preventing or treating diseases caused by damage to the skin barrier function on a gel cream comprising 0.3 to 1.2% by weight of a thickener, 0.1 to 1.5% by weight of a lecithin-treated ceramide mixture, and 1.0 to 12.0% by weight of a polyol moisturizing component. ,
The disease caused by damage to the skin barrier function is any one selected from the group consisting of dryness, dermatitis, atopic dermatitis, allergic dermatitis, and acne.

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