KR102590579B1 - Cosmetic composition including propolis for improving skin troubles and reduction of swlling and preparing method thereof - Google Patents

Abstract

The present invention includes 3 to 10% by weight of silicone oil, 5 to 14% by weight of moisturizer, 0.1 to 4% by weight of emulsifier, 18 to 36% by weight of thickener, 1 to 5% by weight of functional ingredient containing propolis, and 0.1 to 0.1% by weight of additives. It relates to a functional cosmetic containing propolis, which contains 5% by weight and the remaining amount of solvent, and a method for manufacturing the same. The functional cosmetics have better effects such as alleviating inflammation, wrinkles, improving skin troubles, and reducing swelling by increasing the transdermal absorption rate of propolis. Cosmetics can be provided.

Description

Functional cosmetic composition containing propolis effective in improving skin troubles and reducing swelling and manufacturing method thereof {Cosmetic composition including propolis for improving skin troubles and reduction of swelling and preparing method thereof}

The present invention relates to a functional cosmetic containing propolis and a method for producing the same. More specifically, the present invention relates to a functional cosmetic with improved formulation stability that is effective in improving skin troubles and reducing swelling by forming a stable structure of propolis and liposome structure, and It relates to its manufacturing method.

The skin is an organ that exists on the outermost layer of the body and has the function of protecting the human body. It prevents moisture and electrolyte loss from our body and protects us from the penetration of foreign substances. The skin is divided into the epidermis layer, dermis layer, and subcutaneous fat layer. The epidermal layer is composed of keratinocytes, and the outermost keratinous layer of the epidermal layer plays a very important role in the penetration of substances.

Such skin may become sensitive due to changes in the environment, stress from internal factors, or stimulation from external factors, and its moisture retention capacity may decrease. In this case, various skin problems may occur.

In particular, when the skin's ability to retain moisture decreases due to aging or various factors, not only does the occurrence of these skin problems become more accelerated, but the problem of looking older also occurs due to loss of elasticity, formation of wrinkles, and changes to dull skin color.

Accordingly, various efforts are being made to slow down skin aging and create more beautiful skin by generally maintaining the skin's moisture content above a certain level.

As part of these efforts, a general method is to wash the skin and then apply moisturizers such as toners, lotions, creams, etc. to supply moisture to the skin and form a film to physically prevent evaporation of moisture.

The application of such moisturizers is a common practice in daily life. Recently, functional transdermal coating agents containing various active ingredients, i.e. functional cosmetics, have been developed rather than simple moisturizers, making it possible to maintain and improve skin health in a simple and convenient way. It is being done.

Various active ingredients that provide functionality to cosmetics can be obtained through synthesis or extraction. Recently, as public interest in eco-friendliness and safety has increased, the development of functional cosmetics using extracts of natural substances has been mainly conducted.

However, when using natural substance extracts, there is a problem in that the active ingredients are not sufficiently absorbed into the skin and thus the functionality is not fully expressed. Therefore, there is a need to develop new technologies that can improve the skin delivery rate of the active ingredients.

Registered Patent No. 10-2096743 (registered on March 27, 2020)

The present invention seeks to provide a functional cosmetic that is effective in improving skin troubles and reducing swelling and has improved formulation stability, and a method for manufacturing the same.

One embodiment of the present invention for achieving the above-described object is 3 to 10% by weight of silicone oil, 5 to 14% by weight of moisturizer, 0.1 to 4% by weight of emulsifier, 18 to 36% by weight of thickener, and propolis. It relates to a functional cosmetic containing propolis, which includes 1 to 5% by weight of functional ingredients, 0.1 to 5% by weight of additives, and the remaining amount of solvent.

The functional ingredient may be a mixture of propolis powder containing propolis extract and liposomes at a weight ratio of 1:0.05 to 0.4.

The propolis powder may be a mixture of propolis extract and cyclodextrin at a weight ratio of 1:3 to 5.

The additive may include at least one of a metal ion sequestrant, a preservative, a pH adjuster, a coloring agent, and a flavoring agent.

Another embodiment of the present invention relates to a manufacturing method for producing a functional cosmetic containing propolis, specifically, an oil component preparation step of preparing an oil component containing silicone oil; An aqueous component manufacturing step of preparing an aqueous component by mixing an aqueous solvent, a humectant, an emulsifier, a metal ion sequestrant, a preservative, and a pH adjuster; A mixing step of mixing the oil phase component and the aqueous phase component and homomixing them to prepare an emulsion composition; A viscosity adjustment step of increasing viscosity by adding a thickener to the emulsion composition obtained through the mixing step; And a propolis addition step of adding a functional mixture containing propolis to the uniform mixture obtained through the viscosity adjustment step and dispersing it by stirring.

The functional mixture containing the propolis may include a functional ingredient in which propolis powder and liposomes are mixed at a weight ratio of 1:0.05 to 0.4.

In the viscosity adjustment step, at least one or more of pigments and fragrances may be additionally added.

The functional cosmetic containing propolis of the present invention is effective in improving skin troubles and reducing swelling because it contains propolis.

In addition, propolis is encapsulated by liposomes, which can improve transdermal absorption, and this capsule structure maintains a stable structure, which has the advantage of improving formulation stability and the quality of functional cosmetics.

Before explaining in detail the preferred embodiments of the present invention below, the terms and words used in the specification and claims should not be construed as limited to their ordinary or dictionary meanings, but should be interpreted as meanings consistent with the technical idea of the present invention. Please note that it should be interpreted as a concept.

Throughout this specification, when a part "includes" a certain component, this means that it may further include other components rather than excluding other components, unless specifically stated to the contrary.

Throughout this specification, “%” used to indicate the concentration of a specific substance is (weight/weight)% for solid/solid, (weight/volume)% for solid/liquid, and liquid (weight/volume)%, unless otherwise specified. /Liquid means (volume/volume)%.

Below, we will look at embodiments of the present invention. However, the scope of the present invention is not limited to the preferred embodiments below, and those skilled in the art can implement various modifications of the contents described in this specification within the scope of the present invention.

The present invention relates to a functional cosmetic containing propolis, which is effective in improving skin troubles and reducing swelling, and a method for producing the same. Specifically, it relates to a functional cosmetic that is effective in improving skin troubles and reducing swelling by forming a stable structure of propolis and liposome structure and has improved formulation stability, and a method for manufacturing the same.

First, an embodiment of the present invention relates to a functional cosmetic containing propolis, which is effective in improving skin troubles and reducing swelling.

A functional cosmetic containing propolis according to an embodiment of the present invention includes 3 to 10% by weight of silicone oil, 5 to 14% by weight of moisturizer, 0.1 to 4% by weight of emulsifier, 18 to 36% by weight of thickener, and propolis. It contains 1 to 5% by weight of functional ingredients, 0.1 to 5% by weight of additives, and the remaining amount of solvent.

The silicone oil is used to provide moisturizing power to cosmetics and at the same time impart a silky and light feel. The functional cosmetic of the present invention is a silicone in water emulsion composition, in which silicone oil is uniformly dispersed in the functional cosmetic by forming a micelle structure within the water-soluble component by an emulsifier.

The silicone oil may be included in an amount of 3 to 10% by weight in the total functional cosmetic. If it is included in less than 3% by weight, there is a problem that the feeling of use is deteriorated because the silky and light feeling caused by the silicone oil does not appear. If it is included in excess, there is a problem of a sticky residue appearing after application, so it is preferable to include it within the above-mentioned weight range.

The silicone oils include cyclopentasiloxane, cyclohexasiloxane, dimethicone, methyltrimethicone, amodimethicone, phenyltrimethicone, dimethicone/trimethyl siloxy silicate, diphenyldimethicone, triphenylmethicone, and dimethicone. At least one of a homogeneous dispersion of dimethiconol and a copolymer of cyclopentasiloxane and dimethicone/vinyl dimethicone may be used.

Preferably, cyclopentasiloxane, dimethicone, a homogeneous dispersion of dimethicone and dimeniconol, and a copolymer of cyclopentasiloxane and dimethicone/vinyldimethicone can be used as the silicone oil, especially cyclopentasiloxane and dimethicone/vinyldimethicone. When using a copolymer of vinyl dimethicone, it not only provides a soft and silky feel, but also has the advantage of providing a more refreshing texture by allowing a matte finish after use.

The humectant is an ingredient added to improve the moisturizing power of the skin by drawing moisture to the skin, providing moisturizing power to the skin, and preventing evaporation of moisture by forming a moisturizing film on the skin.

Moisturizers can be added at 5 to 14% by weight in functional cosmetics. If added at less than 5% by weight, the moisturizing effect is minimal, and if added at more than 14% by weight, a sticky texture may appear and cause discomfort. It is preferable that it is contained within the above-mentioned weight range.

Various known substances that exhibit a moisturizing effect can be used as such moisturizing agents, but preferably, general moisturizing agents such as glycerin, propanediol, dipropylene glycol, polyol or polyglycerin-3, and trehalose, betaine, adenosine, and niacin. It is preferable to use a functional moisturizer such as amide, panthenol, allantoin, hyaluronic acid, squalene or ceramide NP.

In this case, in addition to the high moisturizing effect of a general moisturizer, additional functions such as soothing effect, skin conditioning effect, regenerative effect, wrinkle improvement, and exfoliation by the functional moisturizer can be given to the functional cosmetic.

In this way, when a general moisturizer and a functional moisturizer are used together as a moisturizer, the general moisturizer and the functional moisturizer are used at a weight ratio of 1: 0.5 to 1.2 in order to provide sufficient moisturizing power and provide additional functions by the functional moisturizer and at the same time secure economic efficiency. It is desirable.

Particularly preferably, glycerin can be used as a general moisturizer, and a mixture of trehalose, panthenol, and allantoin can be used as a functional moisturizer. In this case, it can provide high moisturizing power, and the moisturizing ingredient penetrates deep into the skin as well as the surface of the skin, preventing dryness inside the skin. It has the advantage of preventing acne and having excellent skin soothing and regenerative effects.

The emulsifier is a component added to uniformly mix each component of the functional cosmetic of the present invention, which is a silicone-in-water emulsion composition in which the main component and solvent are water-soluble and include silicone oil.

Specifically, the silicone oil is located inside the micelle structure formed by the emulsifier, so that the micelle structure of the emulsifier and silicone oil can be uniformly dispersed in the water-soluble solvent.

These emulsifiers include polysorbate, sorbitan ester, glycolipid, lysolecithin, sorbitan stearate, glyceryl oleate, glyceryl stearate, polyoxyalkylene alkyl ether, polyoxyalkylene fatty acid ester, alkyl poly. Glucoside, sodium lauryl ether sulfate, stearyl trimethyl ammonium chloride, alkylpolyglyceryl ether, stearyltrimethylammonium chloride, lauryltrimethyl ammonium chloride, distearyldimethyl-ammonium chloride, poly(N,N'-dimethyl-3) , 5-methylenepiperidinium) chloride, cetylpyridinium chloride, alkyltetraammonium salt, alkyldimethylbenzylammonium salt, alkylisoquinolinium salt, dialkyl-morpholinium salt, polyamine fatty acid derivative, amyl alcohol fatty acid derivative, benzalkonium chloride , benzethonium chloride, potassium cetyl phosphate, and sucrose-based surfactants may be used, but are not limited thereto.

Preferably, a polysorbate-based surfactant may be used to ensure the stability and dispersion power of the micelle structure, and more preferably, polysorbate 20 may be used.

These emulsifiers may be included in functional cosmetics at 0.1 to 4% by weight. If they are included in less than 0.1% by weight, mixing and dispersion of silicone oil becomes difficult, and if they exceed 4% by weight, additional water-soluble and oil-soluble components are added. Not only is the mixing and dispersing effect not achieved, but the formulation stability of the functional cosmetic is reduced due to excessive emulsifier ingredients, and it can excessively irritate the skin, causing side effects such as erythema, itchiness, and rash. Therefore, within the above-mentioned weight range. It is desirable to use

The thickener is added to increase the viscosity of the functional cosmetic, and may include at least one of carbomer, xanthan gum, and acrylic polymer. Acrylic polymers include acrylate/C10-30 alkyl acrylate copolymer, ammonium acryloyldimethyltaurate/VP copolymer, ammonium acryloyldimethyltaurate/Behenes-25 methacrylate copolymer, and hydroxyethyl. At least one or more from the group consisting of acrylate/sodium acryloyldimethyl taurate copolymer may be included.

The thickener may be included in functional cosmetics at 18 to 36% by weight, and depending on the content of the thickener, the formulation of the functional cosmetic may change to lotion, emulsion, cream, etc. However, if the content of the thickener is less than 18% by weight, it is difficult to uniformly disperse the propolis and the liposome structure, causing layer separation, and if it exceeds 36% by weight, the viscosity increases to the point that it is difficult to use, so the above-mentioned weight It is desirable to include it within the scope.

The functional ingredient containing propolis is a mixture of propolis powder containing propolis extract and liposomes at a weight ratio of 1:0.05 to 0.4, and may be included in 1 to 5% by weight in the total functional cosmetic.

If the content of the functional ingredient containing propolis is less than 1% by weight, it is difficult to obtain effects such as inflammation, wrinkle relief, trouble improvement, and swelling reduction caused by the functional ingredient containing propolis, and if the content exceeds 5% by weight, In some cases, it may cause skin irritation, so it is preferable that it be included within the above-mentioned weight range.

The propolis extract may be obtained by extracting propolis using a solvent selected from the group consisting of water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, acetone, ethyl acetate, butylacetate, and 1,3-butylene glycol. .

These propolis extracts contain not only sugars and amino acids, but also polyphenols, terpenes, and steroids with flavonoids and phenolic acids as their main ingredients. When used transdermally, they have the effect of relieving skin inflammation and wrinkles. , It is effective in not only improving skin troubles but also reducing swelling.

Since propolis extract is difficult to formulate, problems such as difficulty in dispersing or reduced effectiveness of the propolis extract occur when applied to cosmetics in the form of an extract. Therefore, in the present invention, the workability is improved by powdering the propolis extract, and the efficacy of propolis is increased by encapsulating it with liposomes to improve the absorption of propolis into the skin.

The propolis powder is a mixture of propolis extract and cyclodextrin at a weight ratio of 1:3 to 5. By mixing the propolis extract with cyclodextrin and powdering it, handling during the manufacturing process can be improved. .

The liposome may be an aqueous liposome solution containing 2 to 8% by weight of liposomes.

The functional ingredient containing propolis is propolis powder containing propolis extract encapsulated by liposomes. As this capsule structure is formed, the dispersibility of the propolis powder in functional cosmetics is improved, and the propolis powder is delivered transdermally. Delivery efficiency can be increased.

This capsule structure of propolis and liposomes can be manufactured by mixing and dispersing the functional ingredient mixed with propolis powder and liposomes at a concentration of 40 to 70% by weight in an aqueous solvent.

The size of the capsule structure may be 200 to 800 nm. If it is less than 200 nm, the capsule structure does not contain sufficient functional ingredients, and if it exceeds 800 nm, the transdermal absorption rate decreases, so it is better to control the capsule structure to the size described above. desirable.

In order to control the size of the capsule structure to the above-mentioned size, preferably, conjugated linoleic acid may be additionally added during the manufacturing process of the capsule structure. When conjugated linoleic acid is not included, the size control and shape stability of the capsule structure are relatively poor, but when conjugated linoleic acid is included, the capsule structure is formed to a certain size and its shape can be stably maintained for a long period of time, so the present invention It is preferable that conjugated linoleic acid is additionally included in the functional cosmetic.

In addition, conjugated linoleic acid is absorbed into the dermis along with the propolis extract, maximizing the skin soothing and inflammation-relieving effects of the propolis extract, thereby controlling the size of the capsule structure and stabilizing the structure, as well as enhancing the efficacy of the propolis extract. , it is preferable that conjugated linoleic acid is added together.

Conjugated linoleic acid may be included in the functional cosmetic in an amount of 4 to 9 parts by weight based on 100 parts by weight of the functional ingredient containing propolis. If it is contained in less than 4 parts by weight, the above-mentioned effect is not obtained, and if it is contained in less than 4 parts by weight, the above-mentioned effect is not obtained, and if it is contained in more than 9 parts by weight, If included, there is a problem that the formulation stability of the functional cosmetic is reduced, so it is preferable that it is included within the above-mentioned weight range.

The additive is an ingredient added to provide additional functions to functional cosmetics, and may be included in 0.1 to 5% by weight in the total functional cosmetics.

As such additives, at least one or more of metal ion sequestrants, preservatives, pH adjusters, colorants, and fragrances may be used.

The metal ion sequestering agent is added to improve the stability and usability of functional cosmetics by blocking metal ions contained in functional cosmetics. For example, EDTA may be used, but is not limited to this, and various known chelating agents may be used. You can.

The preservative is added to inhibit or reduce the growth of microorganisms in functional cosmetics. Various known preservatives may be used as the preservative, but preferably 1,2-hexanediol, 1,3-Butylene glycol, Caprylyl Glycol, Glyceryl Caprylate, p-Anisic Acid, Pentylene Glycol At least one selected from the group consisting of Pentylene Glycol and Ethylhexylglycerin can be used, and the types of preservatives listed above have high skin safety, are environmentally friendly, and can provide an additional moisturizing effect. There is an advantage.

The pH adjuster is an ingredient added to stabilize the properties of the cosmetic by adjusting the pH of the functional cosmetic, for example, at least one selected from the group consisting of tromethamine, arginine, potassium hydroxide, and sodium hydroxide. Any one or more may be used, but are not limited thereto.

The pigment is added to adjust the color of the functional cosmetic, and the fragrance is added to impart a scent to the functional cosmetic. The pigment and fragrance may be used without particular restrictions as long as they are materials that can be used in cosmetics.

Another embodiment of the present invention relates to a method for producing a functional cosmetic containing propolis, which is effective in improving skin troubles and reducing swelling. Since a functional cosmetic containing propolis, which is effective in improving skin trouble and reducing swelling according to an embodiment of the present invention, can be manufactured through this manufacturing method, overlapping parts related to the functional cosmetic will be omitted and described below. .

A method for producing a functional cosmetic containing propolis, which is effective in improving skin troubles and reducing swelling according to another embodiment of the present invention, includes the steps of preparing an oily ingredient containing silicone oil; An aqueous component manufacturing step of preparing an aqueous component by mixing an aqueous solvent, a humectant, an emulsifier, a metal ion sequestrant, a preservative, and a pH adjuster; A mixing step of mixing the oil phase component and the aqueous phase component and homomixing them to prepare an emulsion composition; A viscosity adjustment step of increasing viscosity by adding a thickener to the uniform mixture obtained through the mixing step; And a propolis addition step of adding a functional mixture containing propolis to the uniform mixture obtained through the viscosity adjustment step and dispersing it by stirring.

First, the oil component manufacturing step is a step of preparing an oil component containing silicone oil.

This step is to prepare oil ingredients containing silicone oil. When manufacturing functional cosmetics, when two or more types of silicone oils are included or when silicone oil and other oil ingredients are included together, various oil ingredients are mixed at this stage. It can be manufactured as a single oil component.

Mixing of oil components can be performed at room temperature to prevent deterioration of the oil components, and the stirring time or speed is not particularly limited.

The aqueous component manufacturing step is a step of preparing the aqueous component by mixing an aqueous solvent, moisturizer, emulsifier, metal ion sequestrant, preservative, and pH adjuster.

Preferably, the step may be to first prepare an aqueous solvent, and then add each component added to the aqueous phase component one by one and stir to form a homogeneous mixture.

The aqueous solvent may be at least one of water and dipropylene glycol. When dipropylene glycol is used together as a solvent rather than using water alone, functional ingredients containing moisturizers and propolis can be mixed and dispersed more uniformly, and their dispersion state can be maintained stably. , it is preferable to use water and dipropylene glycol together as an aqueous solvent.

As described above, at least one or more ingredients may be used as a moisturizer or emulsifier.

The mixing step is a step of mixing and homomixing the previously prepared oil phase component and the aqueous phase component to prepare an emulsion composition with uniform properties. At this time, in order to form a homogeneous emulsion composition by mixing the water phase component and the oil phase component, it is preferable to homomix while slowly adding the oil phase component to the water phase component.

The viscosity adjustment step is a step of adding a thickener to the emulsion composition obtained through the mixing step to increase the viscosity of the emulsion composition to form a formulation such as lotion, emulsion, or cream. At this time, the formulation may be determined depending on the amount of thickener added.

At this stage, at least one or more of pigments and fragrances may be additionally added, and it is preferable that the pigments be added before the thickener is added, and the fragrances are preferably added after the thickener is added.

Lastly, the propolis addition step is a step of adding the functional mixture containing propolis to the uniform mixture obtained through the viscosity adjustment step and dispersing it by stirring.

The functional mixture containing propolis contains functional ingredients that are a mixture of propolis powder containing propolis extract and liposomes at a weight ratio of 1:0.05 to 0.4.

Specifically, the functional mixture can be prepared by mixing and dispersing the functional ingredients of propolis powder and liposomes in an aqueous solvent at a concentration of 40 to 70% by weight. In this way, in the process of mixing and stirring each ingredient to prepare a dispersion mixture in which propolis powder and liposomes are dispersed in an aqueous solvent, the propolis powder is encapsulated by liposomes and can be stably dispersed in the functional cosmetic. The transdermal delivery efficiency can be improved.

At this time, more preferably, the step of preparing a dispersion mixture in which propolis powder and liposomes are dispersed in an aqueous solvent and then mixing conjugated linoleic acid thereto may be further performed.

In this case, the size of the capsule structure formed by propolis powder and liposomes is controlled to a constant level by conjugated linoleic acid, and the structural stability of the capsule is improved, so the dispersion power of the capsule structure within the functional cosmetic and the transdermal delivery efficiency of the active ingredient And the formulation stability of functional cosmetics can be maintained stably for a longer period of time.

Through the propolis addition step, a functional cosmetic can be finally produced.

The functional cosmetics manufactured through the above process can be stored or packaged after finally undergoing a vacuum degassing process.

The functional cosmetic contains 3 to 10% by weight of silicone oil, 5 to 14% by weight of moisturizer, 0.1 to 4% by weight of emulsifier, 18 to 36% by weight of thickener, 1 to 5% by weight of functional ingredient containing propolis, and 0.1 to 0.1% by weight of additives. It may contain 5% by weight and the remaining amount of solvent.

At this time, the functional ingredient containing propolis may be a mixture of propolis powder containing propolis extract and liposomes at a weight ratio of 1: 0.05 to 0.4, and the propolis powder contains propolis extract and cyclodextrin. It may be a mixture mixed at a weight ratio of 1:3 to 5.

Preferably, the functional cosmetic may further include 4 to 9 parts by weight of conjugated linoleic acid based on 100 parts by weight of the functional ingredient containing propolis.

Hereinafter, the specific actions and effects of the present invention will be explained through an embodiment of the present invention. However, this is presented as a preferred example of the present invention, and the scope of the present invention is not limited by the examples.

[ Manufacturing example ]

First, the oil phase component was prepared by mixing the silicone oils in Table 1. Among the oil phase components, DC 345 is cyclopentasiloxane, DC 1501 is a mixture of cyclopentasiloxane and dimethiconol, DC 200 is dimethicone, and KGS 16 is a copolymer of cyclopentasiloxane and dimethicone/vinyldimethicone.

Next, the aqueous phase component was prepared by sequentially mixing each component constituting the aqueous phase component in Table 1.

Next, the oil phase component was slowly added to the water phase component and homomixed to prepare an emulsion composition, and then a thickener was added thereto and stirred to form a cream formulation.

Thereafter, the functional mixture containing propolis was added and stirred to prepare a functional cosmetic, and the functional cosmetic of Example 1 was prepared by vacuum defoaming.

Ingredient name Content (% by weight) Oily ingredients DC 345 2.00 DC 1501 0.50 DC 200 3.00 KGS 16 0.50 water ingredient water 36.28 EDTA 0.02 dipropylene glycol 8.80 glycerin 5.00 1,2hexanediol 2.00 Ethylhexyl Glycerin 0.10 trehalose 2.00 Tromethamine 0.20 Polysorbate 20 0.60 allantoin 0.20 panthenol 2.00 thickener Ammonium Acryloyldimethyl Taurate
/VP copolymer 0.50 carbomer 29.20 functional mixture water 5.60 propolis powder 1.35 Liposomes (5% aqueous solution) 0.15 Sum 100.00

[ Experiment example One]

Samples were prepared by varying the contents of propolis powder and liposomes contained in the functional mixture containing propolis as shown in Table 2 below, and the trouble improvement effect for each sample was evaluated.

Each sample was prepared with the same ingredients and content ratios as in Table 1, except that the contents of propolis powder and liposomes were added in the weight ratio shown in Table 2 below. In Table 2, the content of propolis powder and liposomes refers to the content ratio in the entire functional cosmetic, and by changing the content of water and carbomer, the addition and deficiency due to the change in the content of propolis powder and liposomes were offset.

Propolis powder (A) Liposome (B) B/A sample 1 1.30 0.05 0.04 sample 2 1.40 0.09 0.06 sample 3 1.35 0.15 0.11 sample 4 1.30 0.50 0.38 sample 5 1.35 0.60 0.44

The trouble improvement effect for Samples 1 to 5 was confirmed through clinical experiments and NO production inhibition effect tests, and the results are listed in Table 3. First, in the clinical experiments, the contents of propolis powder and liposomes were as shown in the table below. After preparing samples with the same ingredients as in Table 1 except that they were added in the weight ratio shown in 2, 10 people were assigned to each sample among adults aged 20 to 28 years old with acne-prone skin. .

Specifically, subjects were asked to use the sample after washing their face in the morning and evening, and after 30 days, the acne improvement effect was scored as 1 point (noticeably worse), 2 points (slightly worse), 3 points (no change), and 4 points. The effect of improving acne was evaluated using a 5-point scale of (slightly improved) and 5 (noticeably improved), and the average value was calculated for each sample, and the results are listed in Table 3.

The NO production inhibition effect test was an experiment to evaluate the production inhibition effect of NO, which acts as a major factor in the occurrence of skin inflammation, and was evaluated using the following method.

First, RAW 264.7 cells, which are mouse macrophages, were cultured in 10% FBS DMEM medium, dispensed into 24-well plates at 4 × 10 ⁵ cells/well, cultured in a 5% CO ₂ constant temperature and humidity chamber for 24 hours, and then removed. Then, each functional cosmetic sample and FBS-free DMEM containing Methylarginine (LNMMA) were treated, and after 30 minutes, NO was induced with lipopolysaccharide (LPS) and cultured for 24 hours.

Afterwards, the NO production inhibition rate was evaluated by calculating the amount of NO in the sample compared to LPS treatment using the NO assay kit, and the results are shown in Table 3 below.

Acne improvement effect (dots) NO production inhibition rate (%) sample 1 3.2 48.5 sample 2 4.0 61.4 sample 3 4.2 63.1 sample 4 4.1 63.8 sample 5 3.5 58.9

Looking at the results in Table 3, samples 2 to 4 were evaluated as having an acne alleviating effect as a result of clinical trials, and the NO production inhibition rate was also found to be high. On the other hand, in the case of sample 1, there was little acne improvement effect, The NO production inhibition rate was also found to be average, and Sample 5 showed a superior effect than Sample 1, but was confirmed to have a significantly lower function compared to Samples 2 to 4.

Therefore, from the results of this experiment, it was confirmed that when the weight ratio of propolis powder and liposomes was 1:0.05 to 0.4, the transdermal delivery efficiency of propolis increased and the skin improvement effect of propolis was significantly improved.

In addition, in order to further maximize this effect, it was found that it is more preferable to include propolis powder and liposomes in a weight ratio of 1:0.06 to 0.38.

[ Experiment example 2]

The same functional cosmetic as in Example 1 was prepared, except that conjugated linoleic acid was additionally added when preparing the functional mixture containing propolis. At this time, conjugated linoleic acid was added in the weight ratio shown in Table 4 with respect to 100 parts by weight of the functional ingredient containing propolis, which is a mixture of propolis powder and liposomes, to prepare various samples, and each sample was subjected to the same clinical experiment as Experimental Example 1. And the NO production inhibition rate was measured, and the results are listed in Table 4.

In addition, each functional cosmetic sample was left in the shade at a temperature of 18°C and a relative humidity of 52% for 1 month to visually observe changes in formulation, and the results are listed in Table 4.

Conjugated linoleic acid (parts by weight) Acne improvement effect (dots) NO production inhibition rate (%) Formulation changes sample 6 0 4.2 63.1 doesn't exist sample 7 2 4.2 64.3 doesn't exist sample 8 4 4.5 74.7 doesn't exist sample 9 6 4.7 78.6 doesn't exist sample 10 9 4.8 75.4 doesn't exist sample 11 12 3.9 52.8 has exist

Referring to the results in Table 4 above, it can be seen that when conjugated linoleic acid is added, the acne improvement effect is improved and the NO production inhibition rate is improved. This is believed to be a result of improved transdermal absorption rate due to improved stability of the capsule structure formed by propolis and liposomes due to conjugated linoleic acid. However, in the case of sample 7, the content of conjugated linoleic acid was low, so this effect of improving efficacy was minimal. In the case of Sample 11, there is a problem that the stability of the capsule structure is reduced and the trouble improvement effect is reduced compared to the case where conjugated linoleic acid is not contained. In addition, due to the excessive content of conjugated linoleic acid, a problem occurred in which the formulation stability was reduced when left for one month.

Therefore, from the results of this experiment, it is desirable to additionally add conjugated linoleic acid to improve the function of functional cosmetics by increasing the structural stability of the capsule structure of propolis and liposomes, especially propolis, which is a mixture of propolis powder and liposomes. It was confirmed that it is preferable to include 4 to 9 parts by weight based on 100 parts by weight of the functional ingredient.

The present invention is not limited to the specific embodiments and descriptions described above, and various modifications can be made by anyone skilled in the art without departing from the gist of the invention as claimed in the claims. and such modifications fall within the protection scope of the present invention.

Claims (6)

Silicone oil 3~10% by weight, moisturizer 5~14% by weight, emulsifier 0.1~4% by weight, thickener 18~36% by weight, functional ingredients including propolis 1~5% by weight, additives 0.1~5% by weight, and Contains a residual amount of solvent,
The functional ingredient containing the propolis is a mixture of propolis powder containing propolis extract, liposomes, and conjugated linoleic acid at a weight ratio of 1:0.06-0.38:4-9, and the propolis powder is encapsulated by liposomes. It is a capsule structure,
The propolis powder is a powdered mixture of propolis extract and cyclodextrin mixed at a weight ratio of 1:3 to 5,
A functional cosmetic containing propolis, characterized in that the size of the capsule structure is 200 to 800 nm.
delete delete According to paragraph 1,
The additives are,
A functional cosmetic containing propolis, comprising at least one of a metal ion sequestrant, a preservative, a pH adjuster, a pigment, and a fragrance.
An oil phase component preparation step of preparing an oil phase component containing silicone oil;
An aqueous component manufacturing step of preparing an aqueous component by mixing an aqueous solvent, a humectant, an emulsifier, a metal ion sequestrant, a preservative, and a pH adjuster;
A mixing step of mixing the oil phase component and the aqueous phase component and homomixing them to prepare an emulsion composition;
A viscosity adjustment step of increasing viscosity by adding a thickener to the emulsion composition obtained through the mixing step; and
A propolis addition step of adding a functional mixture containing propolis to the uniform mixture obtained through the viscosity adjustment step and dispersing it by stirring,
The functional ingredient containing the propolis is a mixture of propolis powder containing propolis extract, liposomes, and conjugated linoleic acid at a weight ratio of 1:0.06-0.38:4-9, and the propolis powder is encapsulated by liposomes. It is a capsule structure,
The propolis powder is a powdered mixture of propolis extract and cyclodextrin mixed at a weight ratio of 1:3 to 5,
A method for producing a functional cosmetic containing propolis, characterized in that the size of the capsule structure is 200 to 800 nm.
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