JP2011006372A - Beauty treatment - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a beauty treatment capable of achieving higher skin-care effects by reducing the irritation caused by the successive use of a chemical peeling agent and improving the effects for ameliorating the skin state (slippy feeling, moist feeling and transparent feeling) by the chemical peeling agent.SOLUTION: The beauty treatment includes repeating the operations of coating an external preparation for the skin containing 1.0-7.0 mass% of an α-hydroxy acid and washing out the preparation after the passage of a prescribed time, especially after the passage of 3-5 min, at an interval of 2-3 days.

Description

  The present invention relates to a cosmetic method, and more particularly to a cosmetic method for the purpose of beautifying skin using a chemical peeling agent such as glycolic acid.

In recent years, for various pigmentation such as fine wrinkles and stains, freckles, liver spots, senile pigment spots, acne, dermatitis scars, burns, burns, wounds and their scars. In addition, for example, chemical peeling using a chemical peeling agent such as α-hydroxy acids such as glycolic acid, lactic acid, malic acid, and tartaric acid, salicylic acid, trichloroacetic acid, and phenol has been actively performed (for example, Patent Documents). 1 and 2).
In chemical peeling, a chemical peeling agent is applied to the skin to peel off an old stratum corneum on the skin surface and further regenerate a new stratum corneum to promote epidermis turnover (metabolism). On the other hand, such chemical peeling agents have strong skin irritation, and there are problems such as discomfort (such as tingling and pain) during chemical peeling treatment, dryness after treatment, inflammation, and rough skin.

  In conventional chemical peeling treatment, a chemical peeling agent with a high concentration of 20% or more is used. In this case, it is usually applied once every two weeks. There are problems such as dryness, inflammation, and rough skin. For this reason, the actual situation is that application at short intervals has not been made.

  Moreover, it is preferable that the chemical stays on the skin in order to improve the skin texture, dullness, acne and the like with the chemical peeling agent. However, the external agent for chemical peeling used in the conventional cosmetic method is dripping at the time of use. There was a problem that it fell and the usability was bad. Moreover, when a lot of thickeners are blended in order to increase the viscosity, there is a problem that it is difficult to wash away when removing.

  As a technique for blending a thickener with an external preparation containing α-hydroxy acid, for example, carboxyvinyl polymer and α-hydroxy acid are blended in a specific blending ratio, or α-hydroxycarboxylic acid and xanthan gum are mixed. An attempt to increase the viscosity of a composition containing an α-hydroxy acid by blending such a heterobiopolysaccharide gum, an inorganic thickener, polyacrylamide, and the like in specific amounts is known (Patent Documents). 3 and 4). Moreover, the external preparation containing alpha-hydroxy acid currently marketed uses xanthan gum or hydroxyethyl cellulose as a thickener.

  However, all of these conventionally known external preparations have poor viscosity stability, and even if they have a high viscosity immediately after production, there is a problem that the viscosity is remarkably lowered during storage, particularly during storage at high temperatures. It was. In particular, when a compound such as α-hydroxy acid is included at a high blending amount and has a low pH, sufficient and stable thickening cannot be achieved. Further, if the amount of the thickener is increased to increase the viscosity at the time of production, the usability is deteriorated, and there is a problem that it is difficult to wash away when removing from the skin.

JP-A-5-139947 International Publication No. 01/017487 Pamphlet Japanese Patent Laid-Open No. 10-218753 JP-A-8-53322

In view of the above circumstances, the present invention reduces the irritation associated with the continuous use of chemical peeling agents, and enhances the effect of improving the skin condition (smooth, moist, transparent) of chemical peeling agents. An object of the present invention is to provide a cosmetic method for applying a chemical peeling agent to the skin, which can provide a higher skin-beautifying effect.
In addition, the present invention reduces the irritation associated with the continuous use of a chemical peeling agent by using an external preparation for skin containing α-hydroxy acid, having a low pH, good viscosity stability, and excellent usability and stability. A cosmetic method for applying a chemical peeling agent to the skin, which can improve the skin condition (smooth, moist and transparent) of the skin by the chemical peeling agent and can provide a higher skin-beautifying effect. The purpose is to provide.

  The present inventor applied a chemical peeling agent containing 1 to 7% by mass of an α-hydroxy acid to the skin every two days, so that irritation by the chemical peeling agent was not enhanced and the skin texture of the chemical peeling agent was increased. The present inventors have found that the effect of improving dullness, acne, etc. is enhanced, and have completed the present invention.

  An object of the present invention is to beautify skin characterized by repeating the operation of washing off after a predetermined time after applying a topical skin preparation containing α-hydroxy acid in an amount of 1.0 to 7.0% by mass for 2 to 3 days. It is a beauty method.

Moreover, this invention is said cosmetics method, Comprising: As said skin external preparation, the following (a)-(c) is used, The thing of pH 2.0-5.0 is used, The cosmetic method characterized by the above-mentioned. It is.
(A) 1.0-7.0 mass% of α-hydroxy acid
(B) 0.1 to 3.0% by mass of a crosslinked N, N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonic acid sodium copolymer
(C) 0.1 to 3.0% by mass of an associative thickener comprising a compound represented by the following general formula (1)
R ¹ -{(O-R ² ) k-OCONH-R ³ [-NHCOO- (R ⁴ -O) n-R ⁵ ] h} m (1)
[Wherein R ¹ represents a hydrocarbon group, R ² and R ⁴ represent a C 2-4 alkylene group which may be the same or different from each other, or a phenylethylene group, and R ³ has a urethane bond. R ⁵ represents a branched or secondary hydrocarbon group, m is a number of 2 or more, h is a number of 1 or more, and k is in the range of 1 to 500. , N is a number in the range of 1 to 200. ]

  Here, the (c) associative thickener is preferably a (polyethylene glycol-240 / decyltetradeceth-20 / hexamethylene diisocyanate) copolymer.

According to the cosmetic method of the present invention, the stimulation by the chemical peeling agent is not enhanced, and it is safe, and the effect of improving skin texture, dullness, acne and the like by the chemical peeling agent can be enhanced.
In addition, by performing the cosmetic method of the present invention using a specific external preparation for skin, it is easy to wash out and has an appropriate viscosity without sagging, and is easy to apply, improving usability.

Embodiments of the present invention will be described below.
In the cosmetic method of the present invention, after applying a skin external preparation containing 1.0 to 7.0% by mass of α-hydroxy acid to the skin, an operation of washing after a predetermined time has elapsed is repeated for 2 to 3 days.
The type, concentration, pH, and the like of the chemical peeling agent can be appropriately selected according to the treatment purpose and skin condition. The amount of the chemical peeling agent used is 1.5 to 3.0 g per time for the entire face, and is usually about 2.5 g. After applying the chemical peeling agent, a cleaning process is performed, but a neutralization process may be performed before that.

  α-Hydroxy acid has been conventionally used as a buffer or neutralizing agent for cosmetics and detergents, and is blended in various cosmetics for the purpose of softening keratin or activating cells. The α-hydroxy acid used in the cosmetic method of the present invention is not particularly limited, and examples thereof include glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, glyceric acid, pyruvic acid, and mandelic acid. Among them, glycolic acid, lactic acid, malic acid, or tartaric acid is particularly preferable because it has an excellent effect of promoting the turnover of the epidermis, and among them, glycolic acid is preferably used. In the external preparation for skin used in the cosmetic method of the present invention, these α-hydroxy acids may be blended singly or in combination of two or more as necessary.

  The concentration of the α-hydroxy acid used in the cosmetic method of the present invention is 1.0 to 7.0% by mass, preferably 2.0 to 6.0% by mass, and more preferably 3.0 to 7.0% by mass. 5.0% by mass. If the amount is less than 1.0% by mass, sufficient chemical peeling effect may not be achieved. If the amount exceeds 7.0% by mass, skin irritation increases.

  In the cosmetic method of the present invention, after applying an external preparation for skin containing 1.0-7.0% by mass of α-hydroxy acid to the skin, it is allowed to stand for a predetermined time and then rinsed for 2-3 days, preferably 2 days. And repeat. The standing time after application is preferably about 3 to 5 minutes. The number of repetitions is one or more times, preferably three or more times, for example, 3 to 7 times. When the number of repetitions is 3, the total number of applications is 4.

  The external preparation for skin used in the cosmetic method of the present invention only needs to contain 1.0 to 7.0% by mass of α-hydroxy acid, and is an aqueous solution system, a solubilization system, an emulsification system, an oil liquid system, or a gel system. , Paste-based, ointment-based, aerosol-based, water-oil two-layer system, water-oil-powder three-layer, and the like, and may be carried on a sheet-like base.

  Moreover, the usage form is also arbitrary, For example, it can be used in arbitrary forms, such as a lotion, a milky lotion, a cream, a pack, a cosmetic liquid.

  The chemical peel external preparation for use in the cosmetic method of the present invention is appropriately blended with other optional ingredients that are usually used in external preparations for skin, such as cosmetics and pharmaceuticals, in addition to the above-described essential components. Depending on the intended dosage form, it can be produced by a conventional method. For example, a skin external preparation for chemical peeling can be prepared by blending the above essential blending components and one or more of the following components.

  As thickeners, gum arabic, carrageenan, caraya gum, gum tragacanth, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose, CMC, hydroxyethylcellulose, hydroxypropylcellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, cellulose dialkyldimethylammonium sulfate, xanthan gum, agar, bentonite, hectorite, AlMg silicate (Begum), laponite, cross-linked N , N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonic acid sodium copolymer, Ethylene glycol -240 / decyltetradeceth -20 / hexamethylene diisocyanate) copolymers, and the like.

  Examples of the neutralizing agent include caustic potash, caustic soda, sodium citrate, sodium carbonate, sodium hydrogen carbonate, ammonia, triethanolamine, L-arginine, L-lysine and the like.

  Examples of the humectant include glycerin, diglycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, sorbitol, fructose, mannose, erythritol, trehalose, xylitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, and caronic acid. It is done.

  Examples of the ultraviolet absorber include paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, Benzoic acid UV absorbers such as N, N-dimethyl PABA butyl ester and N, N-dimethyl PABA methyl ester, anthranilic acid UV absorbers such as homomenthyl-N-acetylanthranilate, amyl salicylate, menthyl salicylate, homo Salicylic acid UV absorbers such as menthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, octyl cinnamate, ethyl-4-isopropylcinnamate, methyl-2,5-diisopropylcinnamate, ethyl-2 , 4-Diisopropylcinna , Methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p -Methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate Cinnamate UV absorbers such as glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, methyl bis (trimethylsiloxane) silylisopentyl trimethoxycinnamate, 3- (4′-methylbenzylidene) -d, 1- Camphor, 3-benzylidene-d, 1-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-methyl Rubenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methyl) Phenylbenzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, dimorpholinopyrida Examples include dinone.

  Examples of the ultraviolet scattering agent include powders of titanium oxide, fine particle titanium oxide, zinc oxide, fine particle zinc oxide, iron oxide, fine particle iron oxide, cerium oxide, and the like.

  As these ultraviolet scattering agents, needle-like, spindle-like, spherical and granular powders are usually used. A fine particle powder having a particle size of 0.1 μm or less is preferred.

  Silicone treatment such as methyl hydrogen polysiloxane and silane coupling agent; metal soap treatment; UV scattering agent that has been hydrophobized by fluorine treatment such as perfluoroalkyl phosphate diethanolamine salt and perfluoroalkyl silane, dextrin fatty acid ester treatment, etc. Is also preferable.

  Examples of liquid oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern castor oil, castor oil, linseed oil , Safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin and the like.

  Examples of the solid fat include cacao butter, palm oil, horse fat, hydrogenated palm oil, palm oil, beef tallow, sheep fat, hydrogenated beef tallow, palm kernel oil, pork fat, beef bone fat, owl kernel oil, hydrogenated oil, cattle Leg fats, moles, hydrogenated castor oil and the like.

  Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, and reduced lanolin. , Jojoballow, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, and the like.

  Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, polyethylene wax, and Fischer-Tropsch wax.

  Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, toluic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the like. Is mentioned.

  Examples of higher alcohols include linear alcohols (eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol); branched chain alcohols (eg, monostearyl glycerin ether (batyl alcohol) ), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, octyldodecanol and the like.

  Synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate Lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, monoisostearic acid N-alkyl glycol, dicapric acid neopentyl glycol, apple Acid diisostearyl, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylo Propane, tetra-2-ethylhexanoate pentaerythritol, glycerol tri-2-ethylhexanoate, glycerol trioctanoate, glycerol triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmi Tate, glyceryl trimyristate, glyceride tri-2-heptylundecanoate, castor oil fatty acid methyl ester, oleyl oleate, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2 -Octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate , 2-ethylhexyl succinate, triethyl citrate, polyoxyethylene-polyoxypropylene random polymer methyl ether.

  Examples of the silicone oil include linear polysiloxanes (for example, dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.); cyclic polysiloxanes (for example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexyl). And silicone resins that form a three-dimensional network structure, various modified polysiloxanes (amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.) It is done.

  Others include lower alcohols such as ethanol; antioxidants such as butylhydroxytoluene, tocopherol, and phytin; antibacterial agents such as benzoic acid, salicylic acid, sorbic acid, paraoxybenzoic acid alkyl ester, and hexachlorophene; acyl sarcosine acids (eg, lauroyl) Organic acid such as sarcosine sodium, glutathione, citric acid, malic acid, tartaric acid, lactic acid; vitamin A and its derivatives, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 and its derivatives, vitamin B12, Vitamin Bs such as vitamin B15 and derivatives thereof, ascorbic acid, ascorbic acid sulfate (salt), ascorbic acid phosphate (salt), vitamin C such as ascorbic acid dipalmitate, α-to Vitamin E, such as ferrol, β-tocopherol, δ-tocopherol, vitamin E acetate, vitamin D, vitamin H, pantothenic acid, pantethine, etc .; nicotinamide, benzyl nicotinate, γ-oryzanol, allantoin, glycyrrhizin Acids (salts), glycyrrhetinic acid and its derivatives, hinokitiol, bisabolol, thymol, inositol, saikosaponin, carrot saponin, hechisaponin, muclodisaponin, saponins, pantothenyl ethyl ether, ethinyl estradiol, arbutin, cephalanthin, placenta extract, etc. Various drugs, borage, clara, corn, orange, sage, yarrow, mallow, thyme, thyme, spruce, spruce, birch, horsetail, loofah, maroni D, Yukinoshita, Arnica, Lily, Artemisia, Peonies, Aloe, Gardenia, Sawara, Hawthorn extract, Hypericum perforatum extract, Iris in extract, Acacia extract, Ginkgo biloba extract, Ibuki-jako extract, Fennel extract, Oolong tea extract, Water Lily extract, Ages extract, Enmezo extract, Ogon extract, Oat extract, Odori extract, Licorice extract, Gardenia extract, Tea extract, Seika ryu extract, Tormentilla extract, Rose extract, Loofah extract, Peppermint extract, Rosemary extract, Royal jelly Plant extracts such as extracts, pigments, sorbitan monolaurate, sorbitan monopalmitate, sorbitan sesquioleate, sorbitan trioleate, monora Polyoxyethylene sorbitan phosphate, polyoxylene sorbitan monostearate, polyethylene glycol monooleate, polyoxyethylene alkyl ether, polyglycol diether, lauroyl diethanol amide, fatty acid isopropanol amide, maltitol hydroxy fatty acid ether, alkylated polysaccharide, alkyl Nonionic active agents such as glucosides and sugar esters, cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide, sodium palmitate, sodium laurate, sodium laurate, potassium lauryl sulfate, alkyl Triethanolamine ether sulfate, funnel oil, linear dodecylbenzene sulfate, polyoxyethylene hardened Shea oil maleic acid, anionic surfactants such as acyl methyl taurine, amphoteric surfactants, .delta.-tocopherol, antioxidant such as butylhydroxytoluene, phenoxyethanol, preservatives such as paraben and the like.

The particularly preferred skin external preparation for chemical peeling used in the cosmetic method of the present invention is as follows.
That is, the said external preparation for skin contains (a)-(c), and pH is 2.0-5.0.
(A) 1.0-7.0 mass% of α-hydroxy acid
(B) 0.1 to 3.0% by mass of a crosslinked N, N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonic acid sodium copolymer
(C) 0.1 to 3.0% by mass of an associative thickener comprising a compound represented by the following general formula (1)
R ¹ -{(O-R ² ) k-OCONH-R ³ [-NHCOO- (R ⁴ -O) n-R ⁵ ] h} m (1)
[Wherein R ¹ represents a hydrocarbon group, R ² and R ⁴ represent a C 2-4 alkylene group which may be the same or different from each other, or a phenylethylene group, and R ³ has a urethane bond. R ⁵ represents a branched or secondary hydrocarbon group, m is a number of 2 or more, h is a number of 1 or more, and k is in the range of 1 to 500. , N is a number in the range of 1 to 200. ]

((B) Cross-linked N, N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonic acid sodium copolymer)
As the cross-linked sodium N, N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonate of component (b), sodium N, N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonate- N, N-methylenebisacrylamide copolymer is preferred, and this copolymer is also referred to as (dimethylacrylamide / acryloyldimethyltaurine Na) crosspolymer.
The (dimethylacrylamide / acryloyldimethyltaurine Na) crosspolymer can be produced by the method described in Japanese Patent No. 3708531.

  The blending amount of the component (b) in the external preparation for skin is 0.1 to 3.0% by mass, preferably 0.5 to 2.0% by mass, based on the total amount of external preparation for skin. Preferably it is 1.0-1.5 mass%. When the blending amount of the component (b) is too small, the viscosity is too low and it tends to sag, or when the viscosity is secured with the component (c), it becomes difficult to apply. (B) When there are too many compounding quantities of a component, it will become difficult to wash away.

((C) Associative thickener)
The associative thickener of component (c) in the external preparation for skin is represented by the above general formula (1).
This associative thickener is a copolymer having a hydrophilic group as a skeleton and a hydrophobic portion at the terminal, and the hydrophobic portions of the copolymer are associated with each other in a water-soluble medium to exhibit a thickening action.

The hydrophobic modified polyurethane represented by the above general formula (1) is, for example, one or two or more polyether polyols represented by R ¹ -[(O—R ² ) k—OH] m and R ³ — ( NCO) One or more polyisocyanates represented by h + 1 are reacted with one or more polymonoalcohols represented by HO— (R ⁴ —O) n—R ⁵ . Can be obtained.

In this case, R ^{1 to} R ⁵ in the general formula (1) are R ¹ -[(O—R ² ) k—OH] m, R ³ (NCO) h + 1, HO— (R ⁴ —O) used. ) determined by n-R ⁵ . The charging ratio of the three members is not particularly limited, but the ratio of the hydroxyl group derived from polyether polyol and polyether monoalcohol to the isocyanate group derived from polyisocyanate is NCO / OH = 0.8: 1 to 1.4: 1. Is preferred.

The polyether polyol compound represented by R ¹ — [(O—R ² ) k—OH] m that can be preferably used to obtain the associative thickener represented by the general formula (1) has an m value of These polyols can be subjected to addition polymerization of alkylene oxides such as ethylene oxide, propylene oxide, butylene oxide, epichlorohydrin, styrene oxide, and the like.

  Here, as the polyol, those having 2 to 8 valences are preferable. For example, dihydric alcohols such as ethylene glycol, propylene glycol, butylene glycol, hexamethylene glycol and neopentyl glycol, glycerin, trioxyisobutane and 1,2,3- Butanetriol, 1,2,3-pentatriol, 2-methyl-1,2,3-propanetriol, 2-methyl-2,3,4-butanetriol, 2-ethyl-1,2,3-butanetriol 2,3,4-pentanetriol, 2,3,4-hexanetriol, 4-propyl-3,4,5-heptanetriol, 2,4-dimethyl-2,3,4-pentanetriol, pentamethylglycerin Pentaglycerin, 1,2,4-butanetriol, 1,2,4-pentanetriol, trimethylolethane, Trihydric alcohols such as limethylolpropane, pentaerythritol, 1,2,3,4-pentanetetrol, 2,3,4,5-hexanetetrol, 1,2,4,5-pentanetetrol, 1, Tetravalent alcohols such as 3,4,5-hexanetetrol, pentahydric alcohols such as adnit, arabit, and xylit, hexavalent alcohols such as dipentaerythritol, sorbit, mannitol, and exit, and octavalent alcohols such as sucrose Etc.

In addition, R ² is determined by the alkylene oxide, styrene oxide, or the like to be added, and is particularly easily available. In order to exhibit an excellent effect, alkylene oxide or styrene oxide having 2 to 4 carbon atoms is preferable.

Alkylene oxide, styrene oxide and the like to be added may be homopolymerization, two or more kinds of random polymerization, or block polymerization. The adding method may be a normal method. The degree of polymerization k is 0 to 1000, preferably 1 to 500, and more preferably 10 to 200. The ratio of ethylene group occupying the R ² is preferably When it is 50 to 100 wt% of the total R ^2, good associative thickener is obtained this purpose.

Further, R ¹ - molecular weight of ^{[(O-R 2) k} -OH] m is preferably from 500 to 100,000, particularly preferably from 1,000 to 50,000.

There are two polyisocyanates represented by R ^3- (NCO) h + 1 that can be preferably used to obtain the hydrophobically modified polyether urethane represented by the general formula (1) in this external preparation for skin. It will not specifically limit if it has the above isocyanate groups. For example, aliphatic diisocyanate, aromatic diisocyanate, alicyclic diisocyanate, biphenyl diisocyanate, diisocyanate of phenylmethane, triisocyanate, tetraisocyanate and the like can be mentioned.

  Moreover, you may use with the dimer and trimer (isocyanurate coupling | bonding) of these polyisocyanate compounds, and you may make it react with an amine and use it as a biuret.

Further, polyisocyanates having urethane bonds obtained by reacting these polyisocyanate compounds with polyols can also be used. As a polyol, the thing of 2-8 valence is preferable, and the above-mentioned polyol is preferable. Incidentally, R ³ - (NCO) if the h + 1 using trivalent or more polyisocyanates, polyisocyanate preferably has the urethane bond.

The polyether monoalcohol represented by HO— (R ⁴ —O) n—R ⁵ that can be preferably used to obtain the hydrophobic modified polyether urethane represented by the general formula (1) in the external preparation for skin is As long as it is a polyether of linear, branched or secondary monohydric alcohol, it is not particularly limited. Such a compound can be obtained by addition polymerization of alkylene oxide such as ethylene oxide, propylene oxide, butylene oxide, epichlorohydrin, styrene oxide or the like to a linear, branched or secondary monohydric alcohol.

  As a method for producing the compound represented by the above general formula (1), it can be obtained by heating and reacting at 80 to 90 ° C. for 1 to 3 hours in the same manner as in the reaction of a normal polyether and isocyanate. Can do.

  The most preferred associative thickener (c) in the external preparation for skin is a (polyethylene glycol-240 / decyltetradeceth-20 / hexamethylene diisocyanate) copolymer. The (polyethylene glycol-240 / decyltetradeceth-20 / hexamethylene diisocyanate) copolymer is also referred to as polyethylene glycol-240 / hexamethylene diisocyanate copolymer bisdecyltetradeceth-20 ether. As a commercial product, Adecanol GT- 700 (made by ADEKA) is mentioned.

  The blending amount of the component (c) in the external preparation for skin is 0.1 to 3.0% by mass, preferably 0.5 to 2.0% by mass, based on the total amount of external preparation for skin. Preferably it is 1.0-1.5 mass%. If the blending amount of the component (c) is too small, the viscosity is too low and it tends to sag, or if the viscosity is secured with the component (b), it is difficult to wash away. When there is too much compounding quantity of (c) component, it will become difficult to apply to skin.

  The blending ratio (mass ratio) of the component (b) and the component (c) is preferably (b) :( c) = 1: 0.6 to 1: 1.5, more preferably (b ) :( c) = 1: 0.6 to 1: 1. If the amount of component (c) is too small relative to component (b), it will be difficult to wash away, and if the amount of component (c) is too large relative to component (b), it will be difficult to apply.

((D) titanium oxide)
In the present invention, by further including (d) titanium oxide, the applied part can be visually confirmed after application, and the remaining washing can also be confirmed by the coloring effect.
Since this external preparation for skin contains α-hydroxy acid and is used for chemical peeling, it is removed after a certain period of time after application to the skin, but if the base is transparent, It is difficult to understand the remaining wiping, causing irritation.
(D) As titanium oxide, what is normally used in the cosmetics field | area can be used.

  When the component (d) is blended, the blending amount is 0.1 to 3.0% by mass, preferably 0.5 to 2.0% by mass, more preferably, in the total amount of the external preparation for skin. 1.0 to 1.5% by mass. If the amount is less than 0.1% by mass, a sufficient coloring effect cannot be obtained, and if it exceeds 3.0% by mass, the coloring effect does not increase.

  The pH of the external preparation for skin is 2.0 to 5.0, but preferably from pH 3.0 to 5.0, more preferably pH 3.5 to 4.5, from the viewpoint of skin irritation and effects. is there.

  Moreover, it is preferable that the viscosity of this skin external preparation is 10000-30000 mPa * s / 30 degreeC, More preferably, it is 20000-25000 mPa * s / 30 degreeC. Within this range, the optimum usability such as no dripping and ease of application can be obtained.

  Further, the neutralizing agent to be blended is not particularly limited, and examples thereof include caustic potash, caustic soda, sodium citrate, sodium carbonate, sodium hydrogen carbonate, ammonia, triethanolamine, L-arginine, and L-lysine. In particular, sodium citrate and caustic soda are preferable. In the skin external preparation of this invention, these neutralizing agents may be mix | blended independently or may be mix | blended in combination of 2 or more type as needed.

  The blending amount of the neutralizing agent in the external preparation for skin is preferably 0.1 to 2.0 mass%, more preferably 0.5 to 1.5 mass%, based on the total amount of external preparation.

  In addition to the α-hydroxy acid, the external preparation for skin contains any other exfoliating agent such as N, N, N-trimethylglycine (TMG), L-serine, malonic acid, or succinic acid. Further, it may be included. By further blending such a keratin remover, a higher skin beautifying effect can be brought about.

Hereinafter, the present invention will be described in more detail with reference to examples. The present invention is not limited to these examples. Unless otherwise specified, the blending amount indicates mass%.
Prior to the examples, the evaluation method used in the present invention will be described.

(1) Evaluation method of effect (application of external skin preparation for chemical peeling)
Based on the following prescription, a skin exfoliating agent for chemical peeling was prepared, and the sample of the prescription example shown in Table 1 was applied 10 times per group at the frequency shown in Table 1 (every 1-4 days) for a total of 4 times. It was. The method of application is to apply the external preparation to the fingers after washing the face at night, and spread it evenly around the eyes, around the mouth, nostrils and hairline. Leave it for 5 minutes, and rinse it with running water or lukewarm water so that it does not rub hard.
Evaluation of the absence of irritation during the application period of the chemical peeling agent and evaluation of the skin condition (smooth feeling, smooth feeling) were evaluated based on the following evaluation criteria. Subsequently, the average of the evaluation points given by each person was calculated and evaluated based on the following evaluation criteria.

(Evaluation criteria for skin condition)
5 points: Excellent.
4 points: Excellent.
3 points: Normal.
2 points: Inferior.
1 point: Very inferior.

(Evaluation criteria for lack of stimulation)
5 points: There was no irritation or almost no feeling.
4 points: A weak stimulus was felt.
3 points: I certainly felt a stimulus.
2 points: A strong stimulus was felt.
1 point: I felt a very strong or unbearable stimulus.

(Evaluation criteria)
A: The average score is 4 or more and 5.
A: The average score is 3 or more and less than 4.
Δ: The average score is 2 or more and less than 3.
X: The average point is 1 or more and less than 2.

Formulation Example 1
Glycolic acid Concentrations listed in Table 1 Cross-linked N, N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonic acid sodium copolymer 1.5% by mass
(PEG-240 / decyltetradeceth-20 / HDI) copolymer 1.0
(Adecanol GT-700 (manufactured by ADEKA))
Dynamite Glycerin 5.0
1,3-butylene glycol 5.0
Sodium citrate 1.0
Caustic soda 1.2
PPG-13 decyltetradeces-24 0.5
Phenoxyethanol 0.3
Titanium oxide 1.5
Fragrance 0.01
Purified water residue

(Production method)
After dissolving the crosslinked N, N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonate sodium copolymer in ion-exchanged water, it is dissolved by adding glycolic acid, and neutralized by adding sodium hydroxide. did. A copolymer (PEG-240 / decyltetradeceth-20 / HDI) dissolved in advance in a part of purified water was mixed, and then the remaining components were dissolved and filtered to obtain an external preparation.

(Synthesis of cross-linked N, N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonic acid sodium copolymer)
Dissolve 35 g of dimethylacrylamide (manufactured by Kojin), 17.5 g of 2-acrylamide-2-methylpropanesulfonic acid (manufactured by Sigma) and 7 mg of methylenebisacrylamide in 260 g of ion-exchanged water, and adjust the pH to 7.0 with sodium hydroxide. To a 1000 ml three-necked flask equipped with a reflux apparatus, 260 g of n-hexane, 8.7 g of polyoxyethylene (3) oleyl ether (Emarex 50 3, manufactured by Japan Emulsion) and epolyoxyethylene (6) oleyl ether (Emma) (Rex 50 6, made by Nippon Emulsion) Add 17.6g, mix and dissolve, and replace with N2. An aqueous monomer solution is added to the three-necked flask and heated to 65 ° C. to 70 ° C. in an oil bath while stirring in an N 2 atmosphere. After confirming that the system is in a translucent microemulsion state when the temperature of the system reaches 65 ° C. to 70 ° C., 2 g of ammonium persulfate is added to the polymerization system and polymerization is started. A microgel is formed by maintaining the polymerization system at 65-70 ° C. with stirring for 3 hours. After the polymerization is completed, acetone is added to the microgel suspension to precipitate the microgel, followed by washing with acetone three times to remove residual monomer and surfactant. The precipitate is filtered and dried under reduced pressure to obtain a dried white powdered microgel.

Formulation example 2
(1) Lactic acid Concentrations listed in Table 1 (2) Dipropylene glycol 5.0% by mass
(3) Dynamite glycerin 1.0
(4) Crosslinked N, N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonic acid sodium copolymer 1.3
(5) (PEG-240 / decyltetradeceth-20 / HDI) copolymer 1.0
(6) Caustic potash 1.0
(7) Sodium citrate 3.0
(8) Dipotassium glycyrrhizinate 0.05
(9) EDTA-2Na 0.02
(10) Ethanol 3.0
(11) PEG-60 hydrogenated castor oil 0.3
(12) Phenoxyethanol 0.3
(13) Fragrance 0.01
(14) Titanium oxide 1.0
(15) Purified water balance
After (4) is dissolved in (15), (1), (2), (3), (6), (7), (8), (9) are dissolved, and in advance with some purified water What was dissolved by heating (5) was mixed. Thereafter, (11), (12) and (13) were dissolved and mixed in (10), and (14) was dispersed, followed by filtration.

Example 1 (Test Examples 1 to 8)
An external preparation for chemical peeling consisting of the formulation examples shown in Table 1 below was applied to the skin by the method described in Table 1, and the absence of irritation and skin condition (smooth feeling, smooth feeling) were evaluated according to the above criteria. The results are also shown in Table 1.

  By applying the chemical peeling external preparation every 2 or 3 days, the irritation caused by the chemical peeling external preparation is reduced compared to every other day, and compared to every 4 days. The skin improvement effect of the external preparation for chemical peeling was enhanced.

  Below, the formulation example of the external agent for chemical peeling applicable to the beauty method of this invention is shown. In addition, all compounding quantities are represented by the mass% with respect to the product whole quantity.

Formulation Example 3 Lotion (1) Glycolic acid 5.0
(2) Lavender extract 1.0
(3) Tocopherol acetate 0.01
(4) Glycerin 4.0
(5) 1,3-butylene glycol 4.0
(6) Ethanol 8.0
(7) Polyoxyethylene (60) hydrogenated castor oil 0.5
(8) Methylparaben 0.2
(9) Citric acid 3.15
(10) Fragrance 0.05
(11) Purified water residue

(Manufacturing method)
Dissolve glycolic acid, lavender extract, citric acid, glycerin, and 1,3-butylene glycol in purified water. Separately, polyoxyethylene (60) hydrogenated castor oil, tocopherol acetate, fragrance, and methylparaben were dissolved in ethanol, solubilized by adding to the above-described purified aqueous solution, and filtered to obtain a lotion.
By applying this lotion every 2 days, the irritation caused by the chemical peeling agent was reduced as compared with every other day, and the skin improvement effect was enhanced as compared with every 4 days.

Formulation Example 4 Cream (1) Cetostearyl alcohol 3.5
(2) Squalane 40.0
(3) Beeswax 3.0
(4) Reduced lanolin 5.0
(5) Ethylparaben 0.3
(6) Polyoxyethylene (20) sorbitan monopalmitate 2.0
(7) Stearic acid monoglyceride 2.0
(8) Sodium N-stearoyl glutamate 0.5
(9) Octyl methoxycinnamate 1.0
(10) Retinol acetate 2.0
(11) Evening primrose oil 0.05
(12) Perfume 0.03
(13) Lactic acid 7.0
(14) Potassium hydroxide 1.5
(15) Dipotassium glycyrrhizinate 0.05
(16) Polyethylene glycol 1500 5.0
(17) Purified water residue

(Manufacturing method)
Setostearyl alcohol, squalane, beeswax, reduced lanolin, ethyl paraben, polyoxyethylene (20) sorbitan monopalmitate, stearic acid monoglyceride, sodium N-stearoyl glutamate, octyl methoxycinnamate, retinol acetate, evening primrose oil, fragrance Dissolve by heating (oil phase), dissolve lactic acid, potassium hydroxide, dipotassium glycyrrhizinate and polyethylene glycol 1500 in purified water and keep at 70 ° C. (aqueous phase), and add the oil phase to the aqueous phase with stirring. The mixture was homomixed to make the emulsified particles fine, and then rapidly cooled with stirring to obtain a cream.
By applying this cream every 2 days, the irritation by the chemical peeling agent was reduced compared to every other day, and the skin improvement effect was enhanced compared to every other day.

Formulation Example 5 Emulsion (1) -2-Ethylhexyl paradimethylaminobenzoate 0.1
(2) Di-2-methoxycinnamic acid mono-2-ethylhexyl 0.2
(3) Stearic acid 1.5
(4) Cetyl alcohol 0.5
(5) Beeswax 2.0
(6) Polyoxyethylene (10) monooleate 2.0
(7) L-arginine 2.3
(8) Dry seawater 0.02
(9) PCA-Na 0.05
(10) Tartaric acid 3.0
(11) Yukinoshita extract 2.0
(12) Licorice extract 0.5
(13) Glycerin 3.0
(14) Ethanol 3.0
(15) Ethylparaben 0.3
(16) Perfume 0.03
(17) Carboxyvinyl polymer 0.12
(18) Purified water residue

(Manufacturing method)
Tartaric acid, Yukinoshita extract, licorice extract, L-arginine, seawater dried product, PCA-Na, propylene glycol, glycerin, ethanol and carboxyvinyl polymer are added to purified water and dissolved by heating and kept at 70 ° C. (aqueous phase). The other ingredients are mixed, dissolved by heating and kept at 70 ° C. (oil phase). Preliminarily emulsify by adding the oil phase to the aqueous phase, and uniformly emulsify with a homomixer. Thereafter, it was cooled rapidly with stirring to obtain an emulsion.
By applying this emulsion every 2 days, the irritation by the chemical peeling agent was reduced compared to every other day, and the skin improvement effect was enhanced as compared to every 4 days.

Example 2 (Cosmetics method using cosmetic kit)
A skin care kit comprising a day cream, a night cream, an essence (moisturizing solution), a mask, and the skin external preparation described in Formulation Example 1 above. Day creams, night creams and essences are commercially available and commonly used.
This skin-care kit uses essence and day cream for morning care (morning operation 1), essence and night cream for night care (night operation 1), or a skin external preparation and mask as described in Formulation Example 1. And night cream (night operation 2) are used.
As a method of use, apply after washing your face in the morning and evening. For morning care, perform morning operation 1 every day. For night care, perform night operation 2 every two days, such as night operation 2-night operation 1-night operation 1-night operation 2-night operation 1-night operation 1-night operation 2- The night operation 2 is performed about 4 times.
Moreover, the usage method of night operation 2 is as follows.
(1) Apply the external preparation for skin described in Formulation Example 1 to the fingertips and spread it evenly around the eyes, around the mouth, nostrils and hairline.
(2) Leave for 5 minutes as it is, and rinse with running water or lukewarm water to avoid rubbing strongly, using running water for about 1 minute as a guide.
(3) Next, a mask containing plenty of essence is firmly attached to the skin, and the cosmetic liquid ingredients are supplied to the entire face.
(4) After about 10 minutes, remove the mask and apply night cream.

Claims (6)

  A cosmetic method for beautifying skin, characterized in that after applying a skin external preparation containing 1.0-7.0% by mass of α-hydroxy acid to the skin, the operation of washing off after a predetermined time is repeated for 2-3 days. .   The cosmetic method according to claim 1, wherein the α-hydroxy acid is glycolic acid.   The cosmetic method according to claim 1, wherein after the external preparation for skin is applied to the skin, the operation of washing after a predetermined time elapses is repeated for 2 days.   The beauty method according to claim 1, wherein the predetermined time is 3 to 5 minutes. The cosmetic method according to claim 1, wherein the external preparation for skin contains (a) to (c) and has a pH of 2.0 to 5.0.
(A) 1.0-7.0 mass% of α-hydroxy acid
(B) 0.1 to 3.0% by mass of a crosslinked N, N-dimethylacrylamide-2-acrylamido-2-methylpropanesulfonic acid sodium copolymer
(C) 0.1 to 3.0% by mass of an associative thickener comprising a compound represented by the following general formula (1)
R ¹ -{(O-R ² ) k-OCONH-R ³ [-NHCOO- (R ⁴ -O) n-R ⁵ ] h} m (1)
[Wherein R ¹ represents a hydrocarbon group, R ² and R ⁴ represent a C 2-4 alkylene group which may be the same or different from each other, or a phenylethylene group, and R ³ has a urethane bond. R ⁵ represents a branched or secondary hydrocarbon group, m is a number of 2 or more, h is a number of 1 or more, and k is in the range of 1 to 500. , N is a number in the range of 1 to 200. ]   6. The cosmetic method according to claim 5, wherein the associative thickener (c) is a (polyethylene glycol-240 / decyltetradeceth-20 / hexamethylene diisocyanate) copolymer.