JP2015140330A - MILKY LIQUID EXTERNAL PREPARATION FOR SKIN CONTAINING α-HYDROXY ACID - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an external preparation for skin having a high stability and a feeling of use without stickiness in a milky liquid formulation containing α-hydroxy acid with a high concentration.SOLUTION: We found out that an external preparation for skin characterized by being a milky liquid containing (a) an α-hydroxy acid or a salt thereof, (b) a thickening polymer, (c) a sorbitan fatty acid ester to which a POE chain is not added, and (d) a POE fatty acid ester can solve the subject. And more preferably, a thickening polymer is a carboxyvinyl polymer, the sorbitan fatty acid ester to which the POE chain is not added is a sorbitan monostearate, and the POE fatty acid ester is a POE (150) monostearate or a POE (25) monostearate.

Description

The present invention relates to an emulsion skin external preparation containing an α-hydroxy acid, a thickening polymer, a sorbitan fatty acid ester, and a POE fatty acid ester.

The topical skin preparation has functions to prevent dry skin, improve rough skin, and beautify the skin. In order to enhance these functions, various components are blended in the external preparation for skin. Among them, in recent years, α-hydroxy acid has attracted attention. α-Hydroxy acid is highly effective in preventing and improving aging symptoms and rough skin symptoms, such as promoting skin stratum corneum turnover and improving skin flexibility (for example, Patent Document 1), and should be formulated in cosmetics. Are often seen.

However, α-hydroxy acid dissociates ions in an aqueous solution, and therefore, it may not be preferable in an external preparation for skin due to its influence. In particular, there is a big problem in the stability of the emulsion formulation. The emulsion formulation is in a state of fluidity in which oil is emulsified with a surfactant and the viscosity is increased with a thickening polymer. Therefore, the effect of the surfactant and the thickening polymer is very important in the formulation stability of the emulsion. However, when α-hydroxy acid is added at a high concentration, the HLB of the surfactant is changed to make the emulsified particles fine, the thickening effect of the thickening polymer is reduced, or the viscosity of the preparation is remarkably increased. As a result, the stability of the emulsion preparation is greatly reduced. If a high concentration of surfactant or thickening polymer is added, emulsified particles can be made smaller and the thickening effect can be controlled appropriately, but the stickiness in the feeling of use becomes stronger, which is not preferable as an external preparation for skin. . Further, it is not preferable in terms of skin safety. In gel preparations, methods that have solved the problem have already been reported (for example, Patent Documents 2 and 3), but are not found in emulsions. That is, there has been a demand for an external preparation for skin having a high stability and a non-sticky feeling in an emulsion preparation containing a high concentration of α-hydroxy acid.

JP-A-5-139947 JP-A-9-52814 JP 2009-190986 A

An object of the present invention is to obtain an external preparation for skin having a high stability and a non-sticky feeling in an emulsion preparation containing a high concentration of α-hydroxy acid.

In view of such a situation, the present inventors used various raw materials used in the cosmetics field in combination, and as a result of earnest research aimed at solving the above problems, the following emulsion formulation However, they have found that it is possible to realize a high stability and a non-sticky feeling of use, and have completed the present invention. That is, the present invention is as follows.

<1> (a) α-hydroxy acid or a salt thereof, (b) a thickening polymer, (c) a sorbitan fatty acid ester not added with a POE chain, and (d) an emulsion containing a POE fatty acid ester An external preparation for skin characterized by
<2> The external preparation for skin according to <1>, wherein the α-hydroxy acid or a salt thereof is citric acid or sodium citrate.
<3> The skin external preparation according to <1> or <2>, containing 0.2 to 2% by mass of citric acid or sodium citrate.
<4> The skin external preparation according to any one of <1> to <3>, wherein the thickening polymer is a carboxyvinyl polymer.
<5> The skin external preparation according to any one of <1> to <4>, which contains 0.1 to 1% by mass or more of carboxyvinyl polymer.
<6> The external preparation for skin according to any one of <1> to <5>, wherein the sorbitan fatty acid ester to which no POE chain is added is sorbitan monostearate.
<7> The topical skin preparation according to any one of <1> to <6>, wherein the POE fatty acid ester is POE (150) monostearate or POE (25) monostearate .
<8> The external preparation for skin according to any one of <1> to <7>, comprising methylphenylpolysiloxane.

According to the present invention, it is possible to provide an external preparation for skin having a high stability and a non-sticky feeling in an emulsion preparation containing a high concentration of α-hydroxy acid.

<1> α-Hydroxy acid or salt thereof of the present invention The α-hydroxy acid or salt thereof used in the present invention may be any one generally used in cosmetics and the like. Citric acid and its salt, lactic acid and its salt, hydroxybutyric acid and its salt, tartaric acid and its salt, mevalonic acid and its salt, malic acid and its salt and the like. Of these, citric acid and its salts are preferred. As content of alpha-hydroxy acid or its salt, 0.1-2 mass% is preferable with respect to a skin external preparation, and 0.2-1 mass% is more preferable.

<2> Thickening polymer of the present invention The thickening polymer used in the present invention is a polymer capable of remarkably increasing the viscosity by being dispersed and dissolved in water in a small amount. What is generally used for cosmetics etc. should just be used. Preferred examples include carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, alginic acid and the like, and carboxyvinyl polymer is more preferred. As content of this thickening polymer, 0.1-1 mass% is preferable with respect to a skin external preparation, and 0.3-0.5 mass% is more preferable.

<3> Sorbitan fatty acid ester to which the POE chain is not added according to the present invention The sorbitan fatty acid ester to which the POE chain is not added may be used as long as it is generally used in cosmetics and the like. For example, sorbitan monostearate, sorbitan sesquistearate, sorbitan tristearate, sorbitan monopalmitate, sorbitan sesquipalmitate, sorbitan tripalmitate, sorbitan monomyristate, sorbitan sesquimyristate, sorbitan trimyristate, sorbitan monolaurate Sorbitan sesquilaurate, sorbitan trilaurate, sorbitan monoisostearate, and sorbitan monooleate. Among them, sorbitan monostearate, sorbitan sesquistearate, sorbitan monoisostearate, and sorbitan monooleate are preferable, and sorbitan monostearate is more preferable. As content of the sorbitan fatty acid ester which has not added the POE chain, 0.1-2 mass% is preferable with respect to a skin external preparation, and 0.3-0.8 mass% is more preferable.

<4> POE fatty acid ester of the present invention The POE fatty acid ester used in the present invention is not particularly limited as long as it is generally used in cosmetics and the like. For example, POE (10) monostearate, POE (25) monostearate, POE (45) monostearate, POE (100) monostearate, POE (150) monostearate, POE (150 ) Distearate, POE (10) monoisostearate, POE (25) monoisostearate, POE (45) monoisostearate, POE (100) monoisostearate, POE (150) monoisostearate, POE (10) monooleate, POE (25) monooleate, POE (45) monooleate, POE (100) monooleate, POE (150) monooleate. Of these, POE (150) monostearate or POE (25) monostearate is preferred. As content of POE fatty acid ester, 0.1-3 mass% is preferable with respect to a skin external preparation, and 0.5-1.5 mass% is more preferable.

<6> Methylphenyl polysiloxane of the present invention The methylphenyl polysiloxane used in the present invention is not particularly limited as long as it is generally used in cosmetics and the like. Diphenylsiloxyphenyl trimethicone, phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone are included. As content of methylphenyl polysiloxane, 1-10 mass% is preferable with respect to skin external preparation, and 3-5 mass% is more preferable.

<7> Emulsion skin external preparation of the present invention The emulsion skin external preparation of the present invention contains the above-described components. In addition, there are no particular limitations as long as it is externally administered to the skin. For example, cosmetics including quasi-drugs, skin external goods and the like can be suitably exemplified. Of these, cosmetics are particularly preferred. Although it is applicable to any of basic cosmetics, hair cosmetics, and makeup cosmetics, it is preferably applied to basic cosmetics. Furthermore, the viscosity is preferably 1000 to 15000 mPa · s at 20 ° C., more preferably 5000 to 10000 mPa · s. In addition, an O / W emulsion is preferable.

In addition to the above-mentioned components, the emulsion external preparation for skin of the present invention can contain optional components that are usually used in cosmetics and external preparations for skin. Examples of such optional ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, and hardened coconut oil. Oils such as hardened oil, mole, castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl Alcohol, behenyl alcohol, octyldodecanol, higher alcohol such as myristyl alcohol, cetostearyl alcohol, etc., cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpoly Loxane, linear polysiloxane such as diphenylpolysiloxane, cyclic polysiloxane such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oil such as modified polysiloxane such as fluorine-modified polysiloxane, anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfate, chloride Cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide, betaine surfactants (alkyl betaines, amide betaines) , Sulfobetaine, etc.), imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (Sorbitan monostearate, sorbitan sesquioleate, etc.)
Glycerin fatty acids (such as glyceryl monostearate), propylene glycol fatty acid esters (such as propylene glycol monostearate), hydrogenated castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, monostearic acid) Polyoxyethylene sorbitan, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), POE glycerin fatty acid esters (POE-glycerin monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate). etc)
POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Te Tronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), nonionic surfactants such as sucrose fatty acid ester, alkyl glucoside, polyethylene glycol, glycerin, 1,3-butylene glycol Erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-he Polyhydric alcohols such as sundiol, 1,2-octanediol, moisturizing ingredients such as sodium pyrrolidonecarboxylate, lactic acid, sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum , Curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin sulfate, dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydroxyethyl guar gum, carboxy Methyl guar gum, dextran, keratosulfate, locust bean gum, succinoglucan, caronic acid, chitin, Thickeners such as tosan, carboxymethyl chitin, agar, polyvinyl alcohol, polyvinyl pyrrolidone, carboxy vinyl polymer, alkyl-modified carboxy vinyl polymer, sodium polyacrylate, polyethylene glycol, bentonite, surface may be treated, mica, Powders such as talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate, surface may be treated, bengara, yellow iron oxide, black iron oxide, Cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, surface may be treated, pearlescent agents such as titanium mica, fish phosphorus foil, bismuth oxychloride, red may be raked 202, Red 228, Red 226, Yellow 4, Blue 40 No. 4, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204 Organic dyes such as polyethylene powder, polymethyl methacrylate, nylon powder, organic powders such as organopolysiloxane elastomers, paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamon Acid UV absorber, benzophenone UV absorber, sugar UV absorber, 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane ultraviolet absorbing agents and the like, ethanol, lower alcohols such as isopropanol, vitamin a or a derivative thereof, vitamin B Hydrochloride, vitamin _{B 6} tripalmitate, vitamin _{B 6} dioctanoate, vitamin _{B 2} or derivatives thereof, vitamin _{B 12,} vitamin B such as vitamin _{B 15} or a derivative thereof, alpha-tocopherol, beta-tocopherol, .gamma.-tocopherol, Preferable examples include vitamin E such as vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone and the like.

Hereinafter, the present invention will be described in detail with reference to examples, but it is needless to say that the present invention is not limited to such examples.

<Production Example 1> Production of emulsion skin external preparation of the present invention An emulsion skin external preparation of the present invention was prepared according to the formulation shown in Table 1 (Example 1). That is, while being uniformly dispersed or dissolved by a homomixer, (B) and (C) were sequentially mixed with (A) to prepare a skin external preparation. Moreover, Example 2-17 and Comparative Example 1-4 were similarly prepared with reference to Example 1.

Test Example 1 Stability Evaluation The external preparation for skin prepared in Production Example 1 was stored at 20 ° C. for 1 day, and the stability was evaluated. Evaluation criteria are shown below. Moreover, it stored at 5 degreeC and 40 degreeC for 1 month, and stability was similarly evaluated. The results are shown in Table 4.
1: Stable with no emulsification failure 2: Transparency is slightly higher, but stable without oil re-shrinking.
3: The oil is slightly exposed on the surface of the preparation.
4: The water phase and the oil phase are separated. Cannot be used as a topical skin preparation.

<Test Example 2> Measurement of emulsion particle diameter The emulsion particle diameter of the external preparation for skin used in Test Example 1 was measured. As the apparatus, ELS-Z manufactured by Otsuka Electronics Co., Ltd. was used. The results are shown in Table 5.

<Test Example 3> Viscosity measurement At the same time, the viscosity of the external preparation for skin was measured. The apparatus used was a DIGITAL VISMETRON VDA manufactured by Shibaura System. The results are shown in Table 6.

<Test Example 4> Usability Evaluation Regarding the usability when applying the external skin preparation used in Test Example 1, a questionnaire was conducted on five specialist panels. Evaluation criteria are shown below. The results are shown in Table 7.
1: No feeling of stickiness at all 2: No feeling of stickiness at all 3: 3: Feeling of stickiness is felt a little, but it is a good feeling of use.
4: Feeling sticky

From the results of Tables 4 to 7, it can be seen that the external preparation for skin of the present invention has a high stability and a non-sticky feeling in an emulsion preparation containing a high concentration of α-hydroxy acid.

INDUSTRIAL APPLICABILITY The present invention can be applied to an external preparation for skin having a high stability and a non-sticky feeling in an emulsion preparation containing a high concentration of α-hydroxy acid.

Claims (8)

(A) α-hydroxy acid or a salt thereof, (b) a thickening polymer, (c) a sorbitan fatty acid ester not having a POE chain added thereto, and (d) an emulsion containing a POE fatty acid ester. An external preparation for skin. The external preparation for skin according to claim 1, wherein the α-hydroxy acid or a salt thereof is citric acid or sodium citrate. The skin external preparation according to claim 1 or 2, comprising 0.2 to 2% by mass of citric acid or sodium citrate. The skin external preparation according to any one of claims 1 to 3, wherein the thickening polymer is a carboxyvinyl polymer. The skin external preparation according to any one of claims 1 to 4, which contains 0.1 to 1% by mass of a carboxyvinyl polymer. The external preparation for skin according to any one of claims 1 to 5, wherein the sorbitan fatty acid ester to which no POE chain is added is sorbitan monostearate. The skin external preparation according to any one of claims 1 to 6, wherein the POE fatty acid ester is POE (150) monostearate or POE (25) monostearate. Methylphenyl polysiloxane is contained, The skin external preparation of any one of Claims 1-7 characterized by the above-mentioned.