JP5688237B2 - Topical skin preparation - Google Patents

Description

The present invention is a poly-γ-L-glutamic acid, a salt of poly-γ-L-glutamic acid, a cross-linked poly-γ-L-glutamic acid and a salt of a cross-linked poly-γ-L-glutamic acid Or it is related with the skin external preparation characterized by containing 2 or more types, a starch acrylic acid block polymer, and / or its salt.

In the modern living environment, skin is exposed to a dry environment throughout the year due to the effects of heating in winter and cooling in summer. In response to such a situation, various moisturizers have been added to cosmetics in order to improve the dryness of the skin. In particular, water-soluble polymers have been frequently used for the purpose of retaining moisture in the skin when used in combination with various humectants because of their high water-absorbing properties and film properties. On the other hand, when mixed in a large amount, the sticky feeling is conspicuous and the usability is often impaired. Recently, poly-γ-L-glutamic acid, poly-γ-L-glutamic acid salts, poly-γ-L-glutamic acid cross-linked bodies and poly-γ-L-glutamic acid cross-linked materials having good skin familiarity and less stickiness Body salt has been reported. However, even in these cases, a sticky feeling will still occur if the amount of the compounding ingredients is increased in order to obtain a sufficient moisturizing effect. Therefore, there has been a demand for a preparation capable of obtaining a sufficient moisturizing effect with a small blending amount that does not cause a sticky feeling.

Known for blending poly-γ-L-glutamic acid, poly-γ-L-glutamic acid salts, poly-γ-L-glutamic acid cross-linked bodies and poly-γ-L-glutamic acid cross-linked salts into cosmetics (For example, refer to Patent Document 1, Patent Document 2, and Patent Document 3), and further, it is known to blend the material, carboxyvinyl polymer, and alkyl-modified carboxyvinyl polymer (for example, refer to Patent Document 4). However, it is not known about a composition for external use containing a starch / acrylic acid block polymer and / or a salt thereof.

JP 2008-120725 A JP 2009-57349 A JP 2009-120585 A JP 2009-79027 A

Poly-γ-L-glutamic acid, poly-γ-L-glutamic acid salt, poly-γ-L-glutamic acid cross-linked body, and poly-γ-L-glutamic acid cross-linked salt, which are macromolecules familiar to skin It was an object of the present invention to obtain a composition for external use on the skin having no stickiness and high moisturizing effect by reducing the blending amount as much as possible and obtaining a sufficient moisturizing effect on the skin.

In view of such a situation, the present inventors used a combination of a water-soluble polymer and a moisturizing agent used in the cosmetics field, and as a result of earnest research aimed at enhancing the moisturizing effect, the following, The present invention was completed by finding that the composition for external use as shown in the above has no stickiness and exhibits a sufficient moisturizing effect. That is, the present invention is as follows.

(1) (a) selected from poly-γ-L-glutamic acid, poly-γ-L-glutamic acid salt, poly-γ-L-glutamic acid cross-linked product and poly-γ-L-glutamic acid cross-linked salt A skin external preparation characterized by containing one or more kinds and (b) a starch / acrylic acid block polymer and / or a salt thereof.
(2) The external preparation for skin according to (1), comprising glycerin.

According to the present invention, poly-γ-L-glutamic acid, a salt of poly-γ-L-glutamic acid, a cross-linked poly-γ-L-glutamic acid, and poly-γ-L-, which are macromolecules that are familiar to skin. By reducing the blending amount of the salt of the glutamic acid crosslinked body as much as possible and obtaining a sufficient moisturizing effect on the skin, it is possible to provide a composition for external skin having no stickiness and high moisturizing effect.

<1> Poly-γ-L-glutamic acid, poly-γ-L-glutamic acid salt, poly-γ-L-glutamic acid cross-linked product and poly-γ-L-glutamic acid cross-linked salt poly-γ-L of the present invention -Glutamic acid can be obtained by binding L-glutamic acid having a uniform optical activity. The average molecular weight may be appropriately selected according to the application of the external preparation for skin, etc., but is preferably 100,000 or more, preferably 500,000 or more, more preferably 1,000,000 or more. The salt of poly-γ-L-glutamic acid, the cross-linked poly-γ-L-glutamic acid, and the salt of the poly-γ-L-glutamic acid cross-linked product are obtained from poly-γ-L-glutamic acid. Poly-γ-L-glutamic acid, poly-γ-L-glutamic acid salt, poly-γ-L-glutamic acid crosslinked body and poly-γ-L-glutamic acid crosslinked body salt are commercially available products (manufactured by Toyobo Co., Ltd. AminoPGALE-P "), which can be obtained and used, which is preferable. As the salt state, for example, sodium salt, potassium salt, magnesium salt, calcium salt and the like can be used. Most preferred is the sodium salt. In this specification, the “crosslinked body” means a structure in which molecules of a linear polymer compound are linked by a physical or chemical method, and has a crosslinked structure. It is intended to be a polymer compound whose properties have changed. What is necessary is just to have a crosslinked structure of poly-γ-L-glutamic acid molecules, and other specific configurations are not particularly limited.

<2> Starch / acrylic acid block polymer and / or salt thereof of the present invention The content of the starch / acrylic acid block polymer of the present invention and / or salt thereof in the composition for external use on the skin is 0.0001% by mass to 1 mass% is preferable, 0.001 mass%-0.5 mass% is more preferable, 0.01 mass%-0.1 mass% is especially preferable. If it is 0.0001% by mass or less, it is difficult to obtain a sufficient moisturizing effect, and even if it exceeds 1% by mass, the moisturizing effect is not improved according to the blending amount, resulting in a sticky feeling. There are already commercially available starch / sodium acrylate block polymers, and such commercially available products can be used. Among the commercially available products, as a preferable product, Sunfresh ST-100P manufactured by Sanyo Chemical Industries, Ltd. can be exemplified.

<3> External preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing the essential components. The skin external preparation referred to in the present invention is not particularly limited as long as it is externally administered to the skin. For example, cosmetics including quasi-drugs, skin external goods and the like can be suitably exemplified. Of these, cosmetics are particularly preferred. In particular, it is particularly preferable to apply to a cosmetic for maintaining skin moisture retention. Moreover, the skin external preparation of this invention can take any of the conventionally known lotion dosage form, emulsion dosage form, essence dosage form, cream dosage form, and powder-containing dosage form. As the cosmetic, any of basic cosmetics, hair cosmetics, and makeup cosmetics can be applied, but it is particularly preferable to apply to basic cosmetics.

In the external preparation for skin of the present invention, in addition to the above-mentioned components, optional components that are usually used in cosmetics and external preparations for skin can be contained. Examples of such optional ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, and hardened coconut oil. Oils such as hardened oil, mole, castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl Alcohol, behenyl alcohol, octyldodecanol, higher alcohol such as myristyl alcohol, cetostearyl alcohol, etc., cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpoly Loxane, linear polysiloxane such as diphenylpolysiloxane, cyclic polysiloxane such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oil such as modified polysiloxane such as fluorine-modified polysiloxane, anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfate, chloride Cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide, betaine surfactants (alkyl betaines, amide betaines) , Sulfobetaine, etc.), imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (Sorbitan monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hardened castor oil derivatives, glycerin alkyl ether, POE sorbitan Fatty acid esters (POE sorbitan monooleate, polystearic acid polyoxyethylene sorbitan, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), POE glycerin fatty acid Esters (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid esters and alkyl glucosides, polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene Glycols, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-hexanediol, 1,2-octanediol and other polyhydric alcohols, pyrrolidonecarboxylic Moisturizing ingredients such as sodium acid, lactic acid, sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin Sulfuric acid, dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate Hydroxyethyl guar gum, carboxymethyl guar gum, dextran, keratosulfuric acid, locust bean gum, succinoglucan, caronic acid, chitin, chitosan, carboxymethyl chitin, agar, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, Thickener such as sodium polyacrylate, polyethylene glycol, bentonite, surface may be treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, sulfuric acid Powders such as barium, surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, surface may be treated Good Pearl agents such as titanium mica, fish phosphorus foil, bismuth oxychloride, red 202, red 228, red 226, yellow 4, blue 404, yellow 5, red 505 which may be raked No., Red 230, Red 223, Orange 201, Red 213, Yellow 204, Yellow 203, Blue No. 1, Green No. 201, Green No. 201, Purple No. 201, Red No. 204, etc., polyethylene powder, Organic powders such as polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, paraaminobenzoic acid UV absorber, anthranilic acid UV absorber, salicylic acid UV absorber, cinnamic acid UV absorber, benzophenone UV Absorber, sugar-based ultraviolet absorber, 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy- UV absorbers such as 4′-t-butyldibenzoylmethane, lower alcohols such as ethanol and isopropanol, vitamin A or derivatives thereof, vitamin B ₆ hydrochloride, vitamin B ₆ tripalmitate, vitamin B ₆ dioctanoate, vitamin B ₂ or derivatives thereof, vitamin B ₁₂ such as vitamin B ₁₂ , vitamin B ₁₅ or derivatives thereof, α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E such as vitamin E acetate, vitamin D, vitamin H, Preferred examples include vitamins such as pantothenic acid, panthetin, pyrroloquinoline quinone and the like.

Furthermore, if necessary, blending a water-soluble polymer can also be exemplified as a preferred embodiment. Examples of such a polymer include an alkyl-modified carboxyvinyl polymer and / or a salt thereof. As such an alkyl-modified carboxyvinyl polymer, there are commercially available ones, and such commercially available products can be used. Among the commercially available products, preferred are carbopol 1382, pemilen TR-1, and pemilen TR-2 manufactured by BFGoodrich. The blending amount of such a compound in the external composition for skin is preferably 0.05 to 0.5% by mass.

The skin external preparation of the present invention thus obtained had little stickiness and had a sufficient moisturizing effect.

Hereinafter, the present invention will be described in detail with reference to examples, but it is needless to say that the present invention is not limited to such examples.

<Examples 1 and 2> Production of lotions of the present invention Lotions were prepared according to the formulation shown in Table 1. That is, the components (A) were mixed and dissolved at room temperature. On the other hand, each component of (B) was mixed and heated at room temperature. The mixture of (B) was added to the mixture of (A) and stirred to solubilize. Further, in the lotion of Example 1, Comparative Example 1 in which sodium poly-γ-L-glutamate was replaced with water, Comparative Example 2 in which starch / acrylic acid block polymer was replaced with water, Poly-γ-L-glutamate sodium Comparative Example 3 was also prepared in which the starch / acrylic acid block polymer was replaced with water.

<Example 3> Production of emulsion of the present invention According to the formulation shown in Table 2, an emulsion which is a composition for external use of the skin of the present invention was prepared. That is, the components (A) were mixed and dissolved by heating at 75 ° C. On the other hand, each component of (B) was mixed and dissolved and heated to 75 ° C. (B) was added to the mixture of (A) and stirred to emulsify. Thereafter, the mixture of (C) heated to 75 ° C. and the mixture of (D) were added, and the mixture was stirred and cooled to room temperature to obtain an emulsion.

<Test Example 1> The skin moisture retention test was conducted in a room at 20 ° C. and a relative humidity of 50% for five panelists. The measurement site was washed with warm water at 37 ° C. for 30 seconds, allowed to rest for 20 minutes, and then measured. For the skin on the inner side of the forearm, on the day before the scheduled test date (-1 day), the skin moisture content of the planned test site is measured in advance with SKICON-200EX (manufactured by IBS). Thereafter, gauze (2 cm × 2 cm) impregnated with a 5% sodium lauryl sulfate aqueous solution was contacted for 30 minutes. On the next day (day 0), skin moisture content was measured with SKICON-200EX, and then the test samples shown in Table 1 (Example 1, Comparative Example 1, Comparative Example 2, Comparative Example 3) were applied. The test sample was applied three times a day. The skin moisture content was measured again 1 day and 2 days after application. At the same time, an untreated control test in which no test sample was applied was also performed. The evaluation results are shown in Table 3. During this test, a questionnaire was also conducted regarding the feeling of use when the test sample was applied at the test site (the result was the average value of 5 people). The evaluation criteria are shown below. The evaluation results are shown in Table 4.
1: Does not feel sticky 2: Feels somewhat sticky 3: Feels sticky 4: Feels pretty sticky

<Test Example 2> Moisture transpiration suppression test A test paper (Example 1, Comparative Example 1, Comparative Example 2) was prepared by filtering the upper surface of an acrylic cup filled with water with a filter paper. Comparative Example 3) was applied in the same amount. This was stored in a constant temperature room at 40 ° C. for 24 hours. The weight of the filter paper, the filter paper coated with a test sample, and the filter paper covered with the test sample were measured in advance. After storage, the weight was measured again in the same manner, and the amount of moisture dissipated from the entire system was calculated. The evaluation results are shown in Table 5.

From the results in Tables 3 and 5, it can be seen that the moisturizing effect and moisture transpiration suppressing effect of the lotion according to the present invention are excellent, and from the results in Table 4, it is found that there is little stickiness and usability is good.

INDUSTRIAL APPLICABILITY The present invention can be applied to a moisturizing cosmetic that has no stickiness and is easy to use and has a high moisture transpiration control effect.

Claims (2)

(A) one selected from poly-γ-L-glutamic acid, poly-γ-L-glutamic acid salt, poly-γ-L-glutamic acid cross-linked product and poly-γ-L-glutamic acid cross-linked salt, or A lotion cosmetic comprising 2 or more types and (b) a starch / acrylic acid block polymer and / or a salt thereof. The lotion cosmetic according to claim 1, comprising glycerin.