JP6640520B2 - Oil-in-water emulsion composition - Google Patents

Description

The present invention relates to an oil-in-water emulsified composition containing a whitening component and having a high ultraviolet protection function and high stability.

Many women use whitening or sunscreen cosmetics to achieve skin without spots and freckles. Spot freckles are caused by an increase in the amount of melanin in the skin caused by the stimulation of ultraviolet rays, which is abnormally deposited in the skin. In order to prevent spots and freckles due to sunburn, sunscreen cosmetics containing titanium dioxide or the like having an ultraviolet protection function are generally used. In addition, stains that have already been formed can be dealt with by using a so-called whitening cosmetic in which a whitening component such as a vitamin C derivative or a resorcinol derivative is blended (for example, Patent Document 1). Therefore, it can be said that a combination of a sunscreen cosmetic and a whitening cosmetic is optimal for realizing skin without spots and freckles.

On the other hand, an external preparation for skin containing titanium oxide having an ultraviolet protection function and tranexamic acid as a whitening component is already known (Patent Document 2). However, the dosage form is a water-in-oil (W / O) emulsion, and is not an oil-in-water (O / W) emulsion that can be used even in summer. In addition, when the fine particle titanium dioxide having a further enhanced ultraviolet protection function is used, aggregation of the fine particle titanium oxide occurs due to the influence of tranexamic acid or salt, and it has been difficult to obtain a stable O / W emulsion.

JP-A-2-49715 JP-A-2002-128646

An object of the present invention is to obtain an oil-in-water emulsified composition containing a whitening component and having a high ultraviolet protection function and high stability.

In view of such a situation, the present inventors have used various raw materials used in the cosmetics field in combination, and as a result of diligent research aimed at solving the above-mentioned problems, the following formulation was obtained. It has been found that an oil-in-water emulsified composition containing a whitening component and having high UV protection function and high stability can be realized, and the present invention has been completed. That is, the present invention is as described below.

<1> An oil-in-water emulsion composition containing the following (a), (b), (c), and (d).
(A) polyglycerin fatty acid ester (b) anionic surfactant (c) tranexamic acid (d) fine particle metal oxide <2> the anionic surfactant (b) is an acyl lactic acid and / or a salt thereof. <1> The oil-in-water emulsion composition according to <1>.
<3> The oil-in-water emulsion composition according to <1> or <2>, wherein the fine particle metal oxide (d) is fine particle titanium dioxide and / or fine particle zinc oxide.
<4> The fine particle titanium dioxide is complexed with one or more selected from polymers having a carboxylic acid and / or a carboxylic acid derivative represented by the general formula (1) as a constituent monomer. The oil-in-water emulsion composition according to any one of <1> to <3>, which is characterized in that:
General formula (1)
(Wherein, R is an alkenyl group having 2 to 15 carbon atoms, wherein the alkenyl group may have a hydrogen atom substituted by a carboxyl group or a hydroxy group, and X represents a hydrogen atom, an alkali metal or an additional mole number of 1) To 12 polyoxyalkylene groups)
<5> A polymer having a carboxylic acid and / or a carboxylic acid derivative represented by the general formula (1) as a constituent monomer is polyacrylic acid or polymethacrylic acid, an alkali metal salt of polyacrylic acid or polymethacrylic acid, and The oil-in-water according to any one of <1> to <4>, wherein the oil is one or more selected from the group consisting of polyoxyethylene adducts of polyacrylic acid or polymethacrylic acid. -Type emulsion composition.
<6> The oil-in-water emulsion composition according to any one of <1> to <5>, wherein the polyglycerin fatty acid ester of (a) contains two or more kinds.

According to the present invention, it is possible to provide an oil-in-water emulsified composition containing a whitening component and having a high ultraviolet protection function and high stability.

<1> Polyglycerin fatty acid ester of the present invention The polyglycerin fatty acid ester according to the present invention may be any generally used in cosmetics and the like. The fatty acid preferably has 12 to 22 carbon atoms, and more preferably 18 carbon atoms. Saturated fatty acids and straight-chain fatty acids are preferred. The esterification degree of the fatty acid is preferably from 3 to 6, and more preferably 5. The degree of polymerization of polyglycerin is preferably from 4 to 10, more preferably from 6 to 10, and even more preferably 10.

Specific examples of such a polyglycerin fatty acid ester include, for example, tetraglyceryl trilaurate, tetraglyceryl trimyristate, tetraglyceryl tripalmitate, tetraglyceryl tristearate, tetraglyceryl tribehenate, tetraglyceryl tetralaurate, tetramyristate Tetraglyceryl, tetraglyceryl tetrapalmitate, tetraglyceryl tetrastearate, tetraglyceryl tetrabehenate, tetraglyceryl pentalaurate, tetraglyceryl pentamyristate, tetraglyceryl pentapalmitate, tetraglyceryl pentastearate, tetraglyceryl pentabehenate, trilaurin Hexaglyceryl acid, hexaglyceryl trimyristate, hexaglyceryl tripalmitate Hexaglyceryl tristearate, hexaglyceryl tribehenate, hexaglyceryl tetralaurate, hexaglyceryl tetramyristate, hexaglyceryl tetrapalmitate, hexaglyceryl tetrastearate, hexaglyceryl tetrabehenate, hexaglyceryl pentalaurate, pentamyristin Hexaglyceryl pentapalmitate, hexaglyceryl pentapalmitate, hexaglyceryl pentastearate, hexaglyceryl pentabehenate, decaglyceryl trilaurate, decaglyceryl trimyristate, decaglyceryl tripalmitate, decaglyceryl tristearate, decaglyceryl tribehenate, tetra Decaglyceryl laurate, decaglyceryl tetramyristate, tetrapalmitate Glyceryl, decaglyceryl tetrastearate, decaglyceryl tetrabehenate, decaglyceryl pentalaurate, decaglyceryl pentamyristate, decaglyceryl pentapalmitate, decaglyceryl pentastearate, decaglyceryl pentabehenate, decaglyceryl hexalaurate, hexamyristine Acid decaglyceryl, decaglyceryl hexapalmitate, decaglyceryl hexastearate, and decaglyceryl hexabehenate. These polyglycerin fatty acid esters can be used alone or in combination of two or more, and it is more preferable to combine two or more. It is suitable that the total amount is 0.3 to 5.0% by mass, more preferably 1 to 3% by mass, based on the total amount of the oil-in-water emulsion composition.

The mixing ratio of the polyglycerin fatty acid ester and the anionic surfactant is not particularly limited, but is preferably in the range of 1:10 to 10: 1 by weight. The total amount of the polyglycerin fatty acid ester and the anionic surfactant is preferably 0.1 to 10.0% by weight, more preferably 1 to 3% by weight, based on the total amount of the cosmetic. As such a mixed emulsifier of a polyglycerin fatty acid ester and an anionic surfactant, for example, those described in JP-A-7-284645 can be used. In addition, there is a commercially available product obtained by adding a higher alcohol to such a mixed emulsifier (for example, Nikomulus 41, manufactured by Nikko Chemicals Co., Ltd.), and such a commercially available product can also be used.

<2> Anionic surfactant according to the present invention The anionic surfactant according to the present invention may be any anionic surfactant generally used in cosmetics and the like. Higher fatty acid salts are also included in the anionic surfactant. Among the anionic surfactants, acyl lactic acid and / or a salt thereof are preferable. The acyl group constituting the acyl lactic acid preferably has 12 to 22 carbon atoms, and more preferably 18 carbon atoms. Linear and saturated fatty acids are preferred.

Specific examples of such an acyl group include, for example, a 2-ethylhexanoyl group, a lauroyl group, a myristoyl group, a palmitoyl group, a stearoyl group, an isostearyl group, a behenoyl group, an oleoyl group, a linoleoyl group, and a linolenoyl group. And the like can be suitably exemplified. Of these, stearoyl lactic acid is particularly preferred. Such acyl lactic acid can be used as it is, or a part or all of it can be derived from an alkali salt and used. These salts can be used without any particular limitation as long as they are used in external preparations for the skin. For example, alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium salt and magnesium salt Preferred examples thereof include organic amine salts such as ammonium salts, triethylamine salts, triethanolamine salts and monoethanolamine salts, and basic amino acid salts such as lysine salts and alginates. Particularly preferred salts are alkali metal salts, more preferably sodium salts. These anionic surfactants can be used alone or in combination of two or more, and in a total amount of 0.05 to 5.0% by mass, more preferably 0.1% by mass, based on the total amount of the oil-in-water emulsion composition. It is preferable to contain 1 to 1.0% by mass.

<3> Tranexamic acid according to the present invention The tranexamic acid according to the present invention may be any one that is generally used in cosmetics and the like. The content is preferably 0.01 to 5.0% by mass, more preferably 1 to 2% by mass, based on the total amount of the oil-in-water emulsion composition.

<4> Fine particle metal oxide according to the present invention The fine particle metal oxide according to the present invention refers to one having an average primary particle diameter in a range of 10 to 80 nm. More specifically, fine particles of titanium dioxide, fine particles of zinc oxide, fine particles of zirconium oxide, fine particles of cerium oxide and the like can be preferably exemplified. The surface of these fine particle metal oxides may be coated with an inorganic compound such as silica or alumina, or an organic compound such as fatty acid metal soap or silicone. Among these fine metal oxides, fine titanium dioxide and fine zinc oxide are preferable because of their excellent ultraviolet scattering effect. Particulate titanium dioxide is more preferred.

The fine particle metal oxide according to the present invention can be prepared by a conventional method such as thermal decomposition of the corresponding metal salt in the gas phase, but there are many commercially available products, and the commercially available products are used as they are. You can also. Examples of such fine particle titanium dioxide include “MTY-110M3S”, “MTY-02”, “MT-100TV”, “MT-500HSA”, “MT-100T”, “MT-01”, and “MT-10EX”. , “MT-05”, “MT-100Z”, “MT-150EX”, “MT-100AQ”, “MT-100WP”, “MT-100SA”, “MT-500B”, “MT-500SA”, “ "MT-600B", "MT-500SAS" (manufactured by Teica Co., Ltd.), "Taipec CR-50", "Taipec TTO-M-1", "Taipec TTO-V4" (manufactured by Ishihara Sangyo Co., Ltd.) ), "ST-455", "STT-65CS", "STT-30EHS" (all manufactured by Titanium Industry Co., Ltd.), "Bayer Titanium R-KB-1" (manufactured by Bayer) And the like.
Further, as the fine particle zinc oxide, “MZ-300”, “MZY-303S”, “MZ-306X”, “MZ-500”, “MZY-505S”, “MZ-506X”, “MZY-510M3S”, "MZ-510HPSX", "WSX-MZ-700" (all manufactured by Teica Co., Ltd.), "SANT-UFZO-450", "SANT-UFZO-500" (all manufactured by Miyoshi Kasei Co., Ltd.), " FZO-50 "(manufactured by Ishihara Sangyo Co., Ltd.)," Max Light ZS-032 ", and" Max Light ZS-032D "(all manufactured by Showa Denko KK).

In the present invention, when the fine particle titanium dioxide or fine particle zinc oxide is blended with the oil-in-water emulsion composition, the fine particle titanium dioxide or fine particle zinc oxide is directly mixed with other components constituting the oil-in-water emulsion composition, and It is preferable to form a paste, and to take a step of mixing the paste with other components constituting the oil-in-water emulsion composition. By taking such a step, it becomes possible to more uniformly mix the fine particle titanium dioxide or the fine particle zinc oxide in the oil-in-water emulsion composition.

 The particulate metal oxide in the oil-in-water emulsion composition of the present invention may be blended into either an oil phase or an aqueous phase, or may be blended into both an aqueous phase and an oil phase. Regarding the blending amount, the total amount is preferably 0.1 to 20.0% by mass, more preferably 1.0 to 15.0% by mass, based on the total amount of the oil-in-water emulsion composition. If the compounding amount is less than the lower limit, the protective effect against ultraviolet rays may be insufficient, and if the compounding amount exceeds the upper limit, even if the compounding amount is increased, the ultraviolet protective effect reaches a peak, and the oil-in-water emulsion composition is applied on the skin. It is not preferable since white or creaking may occur when applied.

As described in JP-A-2010-150164, it is particularly preferable to mix the fine particle titanium dioxide in the aqueous phase as a composite from the viewpoint of improving the dispersibility. In preparing this water-dispersed paste, a production example will be described below.

<Production Example 1>
Using titanium dioxide fine particle “MT-05” (manufactured by Teica Co., Ltd., silica-alumina-treated fine particle titanium dioxide), 5 L of an aqueous dispersion of fine particle titanium dioxide of 20 g / L in terms of silica-alumina-treated titanium dioxide and polyacrylic acid (polymerization degree: 5,000) ) A solution prepared by dissolving 20 g (manufactured by Wako Pure Chemical Industries, Ltd.) in 8 L of pure water was mixed, and after aging for 1 hour, the pH of a 2N aqueous sodium hydroxide solution was further adjusted to 5 and aging was performed for 1 hour. This was filtered and washed to obtain a wet cake, which was repulped in pure water to obtain a fine titanium dioxide composite (fine titanium dioxide concentration 25%, pH 7.5).

<5> Oil-in-water emulsion composition of the present invention The oil-in-water emulsion composition of the present invention is not particularly limited as long as it is administered externally to the skin. For example, cosmetics including quasi-drugs Materials, external skin goods and the like can be preferably exemplified. Of these, cosmetics are particularly preferred. Further, the oil-in-water emulsion composition of the present invention can take any of the emulsion, essence, cream, and powder-containing dosage forms that are generally known. As the cosmetic, any of a basic cosmetic, a hair cosmetic, and a makeup cosmetic can be applied, but it is particularly preferable to apply the cosmetic to the basic cosmetic.

The oil-in-water emulsion composition of the present invention may contain optional components usually used in cosmetics in addition to the above components. Optional components include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hardened coconut oil, hardened oil , Mocro, hydrogenated castor oil, beeswax, candelilla wax, carnauba wax, ibota wax, lanolin, oils such as reduced lanolin, hard lanolin, jojoba wax, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, microcrystalline Hydrocarbons such as wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl alcohol , Behenyl alcohol, octyldodecanol, myristyl alcohol, higher alcohols such as cetostearyl alcohol, etc., cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glycerin tri-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, triglycol Synthetic ester oils such as trimethylolpropane isostearate and pentaneerythrit tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpolysiloxane Chain polysiloxane such as diphenylpolysiloxane, cyclic polysiloxane such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine Oils such as silicone oils such as modified polysiloxanes such as modified polysiloxanes, anionic surfactants such as fatty acid soaps (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, alkylethanol triethanolamine ether, etc. Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide, and imidazoline amphoteric surfactants (2-cocoyl-2-imidazolini) Amphoteric surfactants such as potassium hydroxide-1-disodium carboxyethyloxy salt), betaine surfactants (alkyl betaine, amidobetaine, sulfobetaine, etc.), acylmethyltaurine and the like, sorbitan fatty acid esters (sorbitan monohydrate) Stearate, sorbitan sesquioleate, etc.), glycerin fatty acids (glycerin monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hydrogenated castor oil derivatives, glycerin alkyl ether, POE sorbitan fatty acid esters ( POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester (POE-glycerin monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonyl phenyl ether) Pluronic type, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sugar fatty acid esters and alkyl glucosides, polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol Polyol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-hexanediol, polyhydric alcohols such as 1,2-octanediol, pyrrolidone carboxylic acid Moisturizing ingredients such as sodium acid, lactic acid, sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin Sulfuric acid, dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydro Xyethyl guar gum, carboxymethyl guar gum, dextran, keratosulfate, locust bean gum, succinoglucan, caronic acid, chitin, chitosan, carboxymethyl chitin, agar, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, sodium polyacrylate, polyethylene Thickeners such as glycol and bentonite, and powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate which may be surface-treated , Surface treated, inorganic pigments such as red iron oxide, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, navy blue, titanium oxide, zinc oxide, surface treated, titanium mica, fish Such as phosphor foil and bismuth oxychloride Agents, red # 202, red # 228, red # 226, yellow # 4, blue # 404, yellow # 5, red # 505, red # 230, red # 223, orange # 201 which may be laked Nos., Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204, etc., polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer , Cellulose powder, urethane powder, organic powders such as silk powder, powder coated with a biological component analogous polymer such as a copolymer of methacryloyloxyalkylphosphorylcholine and alkyl methacrylate, ethanol, Lower alcohols such as isopropanol, vitamin A or its derivatives, vitamin B6 hydrochloride, vitamin B6 Vitamin B such as repalmitate, vitamin B6 dioctanoate, vitamin B2 or a derivative thereof, vitamin B12, vitamin B15 or a derivative thereof, vitamin Es such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, and vitamin Ds And vitamins such as vitamin H, pantothenic acid and pantethine, and the like, and can be added as an optional component.

Hereinafter, the present invention will be described in more detail based on examples, but the present invention is not limited to the following examples.

<Production Example 2> Production of oil-in-water emulsion composition of the present invention Table 1 According to the formulation shown in Example 1, an oil-in-water emulsion composition of the present invention was prepared. That is, while uniformly stirring with a homomixer, (A) was mixed with (B) and (C) sequentially to prepare an oil-in-water emulsion composition. Further, with reference to Example 1, Examples 2-15 and Comparative Examples 1-3 were similarly prepared. The results are shown in Tables 1 to 3.

<Test Example 1> Evaluation of UV protection function The oil-in-water emulsion composition obtained in Production Example 2 was applied to the back of 20 panelists, and the UV protection index (SPF) was measured according to the Japan Cosmetic Industry Association Law. Was. The results are shown in Tables 1 to 3.

<Test Example 2> Stability evaluation The oil-in-water emulsion composition obtained in Production Example 2 was stored at 40 ° C for 3 months, and the stability at 1 month and 3 months was visually evaluated. The evaluation criteria are shown below. The results are shown in Tables 1 to 3. The dosage form was evaluated by visual evaluation of appearance and observation by a polarizing microscope (OLYNPUS BX51). The results are shown in Tables 1 to 3.
1: Stable without any separation or aggregation of the particulate metal oxide.
2: Stable with little separation and aggregation of the particulate metal oxide.
3: Separation and agglomeration of the fine metal oxide were observed, and the metal oxide was not stable.

From the results of Tables 1 to 3, it is understood that the present invention is an oil-in-water emulsion composition containing a whitening component having a high ultraviolet protection function and high stability.

The present invention can be used for cosmetics and the like.

Claims (5)

An oil-in-water emulsion composition containing the following (a), (b), (c) and (d).
(A) decaglyceryl pentastearate and decaglyceryl tristearate (b) anionic surfactant (c) tranexamic acid (d) fine metal oxide The oil-in-water emulsion composition according to claim 1, wherein the anionic surfactant (b) is acyl lactic acid and / or a salt thereof. The oil-in-water emulsion composition according to claim 1 or 2, wherein the fine metal oxide (d) is fine titanium dioxide and / or fine zinc oxide. The fine particle titanium dioxide is characterized by being complexed with one or two or more selected from polymers having a carboxylic acid and / or a carboxylic acid derivative represented by the general formula (1) as a constituent monomer. The oil-in-water emulsion composition according to any one of claims 1 to 3.
General formula (1)
(Wherein, R is an alkenyl group having 2 to 15 carbon atoms, wherein the alkenyl group may have a hydrogen atom substituted by a carboxyl group or a hydroxy group, and X represents a hydrogen atom, an alkali metal or an addition mole number of 1). To 12 polyoxyalkylene groups) A polymer containing a carboxylic acid and / or a carboxylic acid derivative represented by the general formula (1) as a constituent monomer is polyacrylic acid or polymethacrylic acid, an alkali metal salt of polyacrylic acid or polymethacrylic acid, and polyacrylic acid. 5. The oil-in-water emulsion composition according to claim 1, wherein the composition is at least one member selected from the group consisting of polyoxyethylene adducts of polymethacrylic acid. 6.