KR101325553B1 - Cosmetic Composition for Protecting Skin Comprising Aminolevulinic acid Contained in Liquid Crystal Base - Google Patents

Abstract

The present invention provides a skin protection cosmetic composition and a cosmetic composition prepared by containing aminolevulinic acid (ALA) in a natural liquid crystal emulsion base containing lecithin, ceramide, cholesterol and its derivatives, phytosterol and its derivatives as a main component. It relates to the makeup method used.

Aminolevulinic acid (ALA), liquid crystal emulsification, skin protection

Description

Cosmetic composition comprising a liquid crystalline emulsified base compounded with amino levulinic acid TECHNICAL FIELD

The present invention is formulated with aminolevulinic acid (ALA) having excellent skin improvement effect on the natural liquid crystal emulsifying base to enhance the moisturizing effect by strengthening the skin barrier, antioxidant effect, acne healing effect, atopic improvement effect, and whitening effect. It relates to a cosmetic composition and a cosmetic method using the same.

The skin is an organ that exists at the outermost part of the body. It is an important organ that has various functions and has a great influence on appearance and image.It is composed of various cells and unique structures, covering the outer surface of the body to prevent evaporation of moisture. It is the body that plays the role of the body's primary defense against the external environment, such as controlling the temperature, protecting the human body from external stimuli such as ultraviolet rays, and preventing the invasion of harmful microorganisms.

As such, the components constituting the skin barrier are composed of lipids, the skin surface is covered with a sebaceous membrane, has a lipophilic property, and constitutes a solid skin lipid barrier, so that it is known that the water-soluble effective ingredients are very difficult to penetrate the skin.

In the art, a method of preparing a cosmetic composition by encapsulating an active ingredient in liposomes, capsules, nano-vesicles, etc., in order to increase skin penetration of the water-soluble active ingredients is used. However, these techniques are merely to make the particles finer to facilitate the penetration of the skin, the water-soluble properties as it is not completely solved the problem of penetrating the lipophilic skin barrier.

The present inventors have made diligent efforts to overcome the problems of the prior art as described above. As a result, the water-soluble active ingredient contained in the liquid crystal emulsion by increasing the hydrophilic properties of the stratum corneum by hydrating the skin based on a natural liquid crystal emulsion composed of a composition similar to skin lipids. The present invention was completed by preparing a cosmetic composition capable of increasing skin penetration.

The present invention provides a cosmetic composition for skin protection prepared by containing aminolevulinic acid (ALA) in a natural liquid crystalline emulsion base prepared with lecithin, ceramide, cholesterol and its derivatives, phytosterol and its derivatives as a main component. do.

In the cosmetic composition of the present invention, aminolevulinic acid (ALA) contained in the natural liquid crystal emulsifying base is excellent in moisturizing, anti-inflammatory, acne, atopy, whitening effect, and the like is added to the natural liquid crystal emulsifying base. The cosmetic composition of the present invention is maximized the effect of amino levulinic acid to maximize the skin protection effect (Test Example 1; Moisturizing effect, Test Example 2; Atopy improving effect, Test Example 3; Acne improving effect, Test Example 4 Skin improvement).

The natural liquid crystal emulsified base of the present invention is an oil-in-water (O / W) type having a lamella structure, comprising (1) lecithin and its derivatives, (2) ceramide, (3) cholesterol and its derivatives, and (4) It contains phytosterol and its derivatives as a main component, and it is included in 20.0-99.9% by weight based on the total weight of the cosmetic composition.

The natural liquid crystal emulsifying base of the present invention has (1) 0.1-25.0% by weight of lecithin and its derivatives, preferably 0.3-15.0% by weight, and (2) 0.1-10.0% by weight of ceramide, based on the total weight of the cosmetic composition. 0.3-5.0% by weight, (3) 0.1-10.0% by weight of cholesterol and its derivatives, preferably 0.3-5.0% by weight, (4) 0.1-10.0% by weight, preferably 0.3-5.0% by weight of phytosterol and its derivatives Obtained by adding%, other higher fatty alcohols or higher fatty acids may be added to solidify the liquid crystal structure.

Hereinafter, the components of the liquid crystal emulsified base used in the cosmetic of the present invention will be described in more detail.

The lecithin used in the present invention includes both a lecithin obtained from soybeans, egg yolks, plant seeds and the like, and a hydrogenated lecithin saturated by saturation thereof.

Next, ceramides include sphingosine derived from nature such as synthetic, fermented, yeast and copper, and plants, and derivatives thereof and cerebromide.

Cholesterol and its derivatives are made from esters of synthetic and natural cholesterols and cholesteryl alkylates such as cholesteryl stearate and cholesteryl isostearate made by esterification thereto and cholesteryl alkylates such as cholesterol. Reel glutamate, and the like.

In addition, phytosterol and its derivatives are phytosteryl glutamate made by esterifying amino acids to phytosteryl alkylates such as phytosterol derived from plants and phytosteryl stearate and phytosteryl isostearate and phytosterol. Etc.

Higher fatty alcohols are naturally occurring alcohols having 10-30 carbon atoms, and higher fatty acids are naturally occurring fatty acids having 8-30 carbon atoms.

The water-soluble active ingredient contained in the cosmetic composition of the present invention is an amino levulinic acid excellent in skin anti-aging effect and skin protection effect. The content of the water-soluble active ingredient is 0.001-20.0% by weight, preferably 0.1-10.0% by weight based on the total weight of the cosmetic composition.

The amino levulinic acid, which is a water-soluble active ingredient included in the cosmetic composition of the present invention, has the following characteristics.

Amino levulinic acid is a precursor involved in the biosynthesis of porphyrins, heme (blood), and tetrapyrrole compounds such as vitamin B12 and chlorophyll. It is widely present in nature and plays an important physiological function in vivo.

The amino levulinic acid used in the cosmetic composition of the present invention may be one obtained through a fermentation process.

The cosmetic composition of the present invention can be prepared into any of the formulations conventionally produced in the art and can be used in the form of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, , Oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion (skin), nourishing lotion (milk lotion), nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder. .

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. Especially, in the case of a spray, a mixture of chlorofluorohydrocarbons, propane / Propane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component is selected from aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, or ethoxylated glycerol fatty acid esters.

The cosmetic composition of the present invention is very excellent in moisturizing effect, acne improvement effect, atopy healing effect, whitening effect by strengthening the skin barrier, and their skin absorption is also excellent and the skin protection effect is very excellent.

In addition, the present invention provides a cosmetic method characterized by applying the cosmetic composition for skin protection of the present invention to human skin. The cosmetic process of the present invention refers to all the cosmetic processes for applying the cosmetic composition of the present invention to human skin. That is, all methods known in the art for applying the cosmetic composition to the skin belong to the cosmetic method of the present invention.

The cosmetic composition of the present invention may be used alone or in combination, or may be used by overlapping with other cosmetic compositions other than the present invention. In addition, the cosmetic composition having excellent skin protection effect according to the present invention can be used according to a conventional method of use, and the number of times of use can be varied depending on the skin condition or taste of the user.

When the cosmetic composition of the present invention is a soap, a surfactant-containing cleansing agent, or a surfactant-free cleansing agent, it may be applied to the skin and then wiped off or removed or washed with water. The surfactant-containing cleansing formulation is a cleansing foam, a cleansing water, a cleansing towel, and a cleansing pack. The surfactant-free cleansing formulation may be a cleansing cream, , Cleansing lotion, cleansing water and cleansing gel, but is not limited thereto.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for describing the present invention in more detail and that the scope of the present invention is not limited by these embodiments in accordance with the gist of the present invention .

Preparation Example 1 Manufacturing Method of Natural Liquid Crystal Emulsifying Base

 The natural liquid crystal emulsified base composition composed of the composition shown in Table 1, similar to the lipid of the present invention, was heated to 80 ° C., respectively, to form a single solution, and the aqueous phase was slowly added to the lipid phase, followed by mixing. It was prepared by passing through a high pressure emulsifying machine three times (bar).

Prize ingredient Content (% by weight) A Hydrogenated Lecithin 8.0 cholesterol 2.0 Ceramide (03) 1.0 Cetostearyl alcohol 2.0 PEG-5 Soyasterol 2.0 Caprylic / capric triglyceride 15.0 ethanol 5.0 B glycerin 10.0 Purified water Balance

Preparation Example 2 Preparation of Cosmetics Containing Natural Liquid Crystal Emulsion Base Containing Aminolevulinic Acid

Cosmetics containing a natural liquid crystalline emulsified base containing an aminolevulinic acid of the present invention (Example), cosmetics containing only a natural liquid crystalline emulsified base without using an aminolevulinic acid (Comparative Example 1) Cosmetics (Comparative Example 2) containing no natural liquid crystalline emulsified base contained in the cosmetics of the Examples and cosmetics containing no aminolevulinic acid in the cosmetics of Comparative Example 2 (control) were prepared in the compositions of Table 2 below.

In the case of Example, the B and C phases are gradually added and mixed uniformly at room temperature to form a final product.In the case of Comparative Example, the A and B phases are mixed and heated at 75 ° C., respectively, and emulsified to cool the temperature to 40 ° C. The phases are added and mixed to form the final product. Aminolevulinic acid was used from Coceed Biopharm.

Prize ingredient Example Comparative Example 1 Comparative Example 2 Control Example A






Natural Liquid Emulsifying Base (Manufacturing Example 1) 87.0 87.0 - - Glyceryl stearate - - 2.0 2.0 Cetearyl alcohol - - 2.0 2.0 Polysorbate 60 - - 1.2 1.2 Sorbitan sesquioleate - - 0.8 0.8 Fiji-100 Stearate - - 1.0 1.0 Squalane - - 10.0 10.0 Caprylic / capric triglyceride - - 10.0 10.0 B


glycerin - - 5.0 5.0 Xanthan gum - - 0.1 0.1 Incense, preservative Suitable amount Suitable amount Suitable amount Suitable amount Purified water Balance Balance Balance Balance C Aminolevulinic acid 5.0 - 5.0 -

The content units in the table are by weight.

Test Example  1: moisturizing effect

In order to evaluate the moisturizing power of the cosmetics prepared in Preparation Example 2 (Example, Comparative Example 1, Comparative Example 2, and Comparative Example), the moisture retention ability of the skin to which each cosmetic was applied was measured as follows.

In the constant temperature and humidity room of 22 degreeC and 45% of a relative humidity, the moisture content of 4 weeks after each cosmetics of the said Example and the comparative example was used for 30 test subjects (2 times / day).

As a measuring device, a moisture content measuring instrument (Corneometer CM825, Courage + Khazaka, Germany) was used to measure the moisturizing power by measuring the electric capacity of the skin according to the moisture content of the skin. The results are shown in Table 3 below.

Skin moisturizing effect Weeks of use Example Comparative Example 1 Comparative Example 2 Control Example 0 Week 71.18 70.60 70.77 70.65 4 Week 76.61 71.19 74.28 71.23 4 Week- 0 Week  5.43 0.59 3.51 0.58

Test Example  2. Efficacy test on itch relief

In order to confirm the atopic dermatitis alleviation and treatment effect on the cosmetics prepared in Preparation Example 2 (Example, Comparative Example 1, Comparative Example 2 and Control Example), 30 patients with refractory atopic dermatitis from 2 to 20 years were examined. The group was divided into groups and applied to 10 people per group. The subjects were asked whether they had itching after using the product, and the answers were obtained. The number of people who felt itching is shown in Table 4 below. The definition of itching was defined as the condition in which the hand went more than twice at the site of the itch.

Atopy Improvement product name Itching feeling I don't feel itchy Example 2 8 Comparative Example 1 8 2 Comparative Example 2 4 6 Control Example 9 One

As a result of the test, it was determined that the cosmetic composition according to the present invention had an excellent effect on the relief of itching and also had an effect on improving atopy.

Test Example  3. Measures to improve acne

In order to measure the clinical effect on the improvement of acne for the cosmetics prepared in Preparation Example 2 (Example, Comparative Example 1, Comparative Example 2 and control) was tested on acne holders. That is, while acne has been used for 30 women in their 20s for 10 days, the acne improvement status was confirmed by visual evaluation and the effects thereof are shown in Table 5 below.

Acne improvement product name Good effect Slightly effect no effect Worse Example 4 6 - - Comparative Example 1 - One 9 - Comparative Example 2 3 5 2 - Control Example - One 9 -

Test Example  3: skin brightness improvement effect

In order to evaluate the skin brightness improvement effect of each of the cosmetic preparations (Example, Comparative Example 1, Comparative Example 2 and Control Example) prepared in Preparation Example 2, the skin was applied to each cosmetic was measured as follows. Thirty women were evaluated using Chromameter CR 400 (MINOLTA, Japan) to improve skin brightness 8 weeks after using the product. Skin brightness improvement effect results based on this evaluation is shown in Table 5 below.

Skin brightness improvement effect (L-value) Weeks of use Example Comparative Example 1 Comparative Example 2 Control Example 0 weeks 60.25 60.30 60.24 60.36 8 weeks 61.34 60.42 60.98 60.48 8 weeks-0 weeks 1.09 0.12 0.74 0.10

The results of the above experimental results show that the amino levulinic acid, which is an active ingredient, can be better applied to the skin when a product is made using a natural liquid crystal emulsifying base. It has been shown that the effect of acne, brightness improvement, etc. can be better shown, and skin irritation could not be observed in most of the subjects who applied the cosmetic to the skin.

As described in detail above, the cosmetic composition of the present invention can maximize the efficacy of moisturizing, whitening, acne improvement and itching by stably penetrating the effective amino levulinic acid to the skin at a high concentration without irritation.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the same is by way of illustration and example only and is not to be construed as limiting the scope of the present invention. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (5)

Aminolevulinic acid is contained in a natural liquid crystalline emulsified base comprising (1) lecithin and derivatives thereof, (2) ceramide, (3) cholesterol and derivatives thereof, and (4) phytosterols and derivatives thereof. One, cosmetic composition for protecting the skin. The cosmetic composition for skin protection according to claim 1, wherein the cosmetic composition has a moisturizing effect, an atopy alleviating effect, an acne alleviating effect and a whitening effect.      The cosmetic composition for protecting skin according to claim 1, wherein the content of the natural liquid crystal emulsifying base is 20.0-99.9 wt% based on the total weight of the cosmetic composition. The cosmetic composition according to claim 1, wherein the content of amino levulinic acid is 0.001-20.0% by weight based on the total weight of the cosmetic composition. A cosmetic method using the cosmetic composition of claim 1, wherein the cosmetic composition of claim 1 is applied and applied to human skin.