KR100614816B1 - A stable nanocapsule compositon and cosmetic composition comprising the same - Google Patents

Abstract

The present invention is 1-5% unsaturated lecithin, 1-20% ethanol, 0.1-1% sucrose stearate, 1-5% capric / caprylic triglyceride, 1-20% silk amino acid, 1-20% tocopherol acetate , Nanoparticles containing 0.01 to 5% of vitamin A palmitate, 0.01 to 1% of DEA-cetylphosphate, 0.01 to 1% of vitamin C, 0.01 to 1% of panthenol, 0.1 to 0.5% of BHT (butyrated hydroxy toluene) and purified water as balance A capsule composition and a cosmetic comprising the same are provided.

Nanocapsules, sucrose stearate, lecithin

Description

A stable nanocapsule compositon and cosmetic composition comprising the same

1 is a view showing the particle size distribution of the nanocapsules prepared in Example 1 of the present invention.

2 is a view showing the results of observing the nano-capsules obtained in Example 1 of the present invention with a freeze-fracture scanning electron microscope.

3 is a view showing the results of the image analysis observed two weeks after applying the body lotion prepared in Example 2 of the present invention.

Figure 4 is a view showing the moisture content observed after two weeks at the site of the body lotion prepared in Example 2 of the present invention.

The present invention relates to a nanocapsule composition and a cosmetic comprising the same.

Conventional cosmetics containing nanocapsules have been known. For example, Korean Patent Publication No. 2003-0084120 discloses a cosmetic nanocapsule containing 0.1 to 10% by weight of lecithin, 0.1 to 10% by weight of triglyceride and polysorbate, respectively, and having an average particle diameter of 100 to 150 nm. Is disclosed.

Nanocapsules are generally present in the form of emulsions and are useful for use in cosmetics because of the ease of delivery of active ingredients to the skin. Nanocapsules can capture water soluble and oil soluble active ingredients. Nanocapsules can be prepared by emulsification under high pressure. Nanocapsules may be used as amphiphilic compounds, such as phosphatidyl choline (PC), phosphatidyl ethanolamine (PE), phosphatidyl serine (PS), spinomielin, cardiolipin, plasmalogen, phosphatidic acid, and cerebrosides. Phospholipids form a bilayer and thus have a structure with a closed space from the outside.

Conventionally, such nanocapsules were unstable because they are thermodynamically metastable, prepared by emulsification under high pressure. Thus, there is still a need for more thermodynamically stable nanocapsules even with conventionally known nanocapsules. Accordingly, the inventors of the present invention have found that sucrose stearate has a function of stabilizing nanocapsules while intensively studying a method of stabilizing the nanocapsule composition, and thus, the present invention has been completed.

It is an object of the present invention to provide nanocapsule compositions that are thermodynamically stable and useful for skin health.

Still another object of the present invention is to provide a cosmetic including the nanocapsule composition.

The present invention is 1-5% unsaturated lecithin, 1-20% ethanol, 0.1-1% sucrose stearate, 1-5% capric / caprylic triglyceride, 1-20% silk amino acid, 1-20% tocopherol, A nanocapsule composition is provided comprising 0.01 to 5% of vitamin A, 0.01 to 1% of DEA-cetylphosphate, 0.01 to 1% of vitamin C, 0.04 to 1% of panthenol, 0.1 to 0.5% of BHT and balanced water.

The invention consists of unsaturated lecithin, ethanol, sucrose stearate, capric / caprylic triglycerides, silk amino acids, tocopherols, vitamin A, DEA-cetylphosphate, vitamin C, panthenol, butyrated hydroxy toluene (BHT) and purified water It provides a composition comprising a nano capsule.

In the present invention, "unsaturated lecithin" refers to lecithin (phosphatidylcholine) having an unsaturated bond. Examples of unsaturated lecithin that can be used in the present invention include, but are not limited to, LIPOID S75, LIPOID S100, LIPOID S40, and the like. Lecithin is an amphoteric compound and is the main constituent of the capsule.

In the present invention, sucrose stearate is used as a surfactant. Sucrose stearray has an excellent effect of stabilizing the nanocapsules of the present invention.

Capric / Caprylic Triglycerides are mixed triesters of glycerol, caprylic acid and capric acid. Capric / Caprylic triglycerides may be artificially synthesized or natural capric / caprylic triglycerides may be used. Caprylic acid is obtained from lavender oil, lime oil and peanut oil and is a water-soluble latex. It is formed by the oxidation of octanol. Capric acid is a crystalline fatty acid found in the fats and oils of many plants. The triglycerides of caprylic acid and caproic acid act as barriers to help emollients and moisture bind to the skin.

Silk amino acid means an amino acid constituting silk, and silk amino acid may be artificially synthesized or prepared by hydrolyzing silk. Silk amino acids are a mixture of amino acids called sericin. The silk amino acid is composed of about 18 kinds of amino acids similar to human skin, and it is known to have excellent skin moisturizing effect, attracts skin to prevent wrinkle formation, restore wrinkles already formed, and block UV rays. .

Tocopherol is a compound also known as vitamin E, and various isomers exist. Isomers of tocopherols include alpha, beta, gamma, and delta-tocopherol. Tocopherol has antioxidant activity and is known to act to prevent the oxidation of vitamin A in the body. The degree of antioxidant activity in the isomer is alpha; Beta; Gamma; Delta ratio 1; 1.3; 1.8; As 2.7, delta tocopherol is known to have the strongest antioxidant activity. On the other hand, since tocopherol is unstable itself, many more stable tocopherol derivatives are used. Examples of tocopherol derivatives used in the present invention include, but are not limited to, tocopherol acetate and tocopherol palmitate.

In the present invention, vitamin A includes vitamin A and its derivatives. Vitamin A (beta carotene) protects the mucous membranes of the mouth, nasal and throat, helping to maintain a smooth, smooth, disease-free skin, reducing susceptibility to infections, protecting them from air pollutants, improving vision, and improving night blindness. Helps to form bones and teeth, improves skin elasticity, moisture content and suppleness, and reverses photo-aging symptoms. If you lack vitamin A, your skin will become dry and hard. Vitamin A derivatives are also referred to as retinoids and include, for example, retinol, retinyl palmitate, retinyl linoleate, retinyl acetate. Vitamin A derivatives, such as Retin A, prevent and reverse sun damage. Vitamin A derivatives have properties that exfoliate and strengthen the skin. Vitamin A used in the present invention is preferably vitamin A palmitate, ie retinyl palmitate.

DEA-cetylphosphate (diethanolamine cetyl phosphate) is used to smooth and soften hair.

Vitamin C is a water soluble vitamin. In cosmetic creams, vitamin C is used as a preservative and antioxidant. Vitamin C is essential for healthy teeth, gums and bones. Vitamin C aids in healing wounds and fractures, prevents scurvy, increases resistance to infections, helps prevent the treatment of chronic colds, strengthens blood vessels and aids iron absorption. Vitamin C is also essential for the synthesis of collagen, an intracellular cement that links tissues together. Vitamin C is one of the major antioxidant nutrients. Vitamin C prevents the conversion of nitrates (which are present in cigarette smoke, smog, bacon, lunchmeat, and vegetables) into carcinogens. Moreover, vitamin C helps slow down the production of excess pigment (aging spots) while providing some UV protection. Vitamin C used in the present invention includes vitamin C derivatives. Examples of preferred vitamin C of the present invention include, but are not limited to, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, isopalmityl ascorbate, and glucosyl ascorbate.

 Panthenol is also known as vitamin B5. Panthenol functions as a penetration moisturizer. Panthenol plumps and moisturizes the hair shaft, making the hair look thicker and reducing the formation of cracked ends.

Butyrated hydroxy toluene (BHT) is used as a peeling agent. BHT is a naturally derived acid that has a strong keratin elimination effect that removes dead skin cells. It has an excellent effect on acne, and peeling.

The nanocapsule composition of the present invention contains 1 to 5% of unsaturated lecithin, ethanol, capric / caprylic triglycerides, silk amino acids, tocopherols, vitamin A, DEA-cetylphosphate, vitamin C, panthenol and butyrated hydroxy toluene (BHT). 1 to 20%, 1 to 5%, 1 to 20%, 1 to 20%, 0.01 to 5%, 0.01 to 1%, 0.01 to 1%, 0.01 to 1%, and 0.1 to 0.5% The remainder consists of purified water. In the present invention, unless otherwise specified,% means weight%.

 Preferred embodiments of the nanocapsule composition of the present invention are 1 to 5% unsaturated lecithin, 1 to 20% ethanol, 0.1 to 1% sucrose stearate, 1 to 5% capric / caprylic triglyceride, and 1 to 5 silk amino acids. 20%, Tocopherol Acetate 1-20%, Vitamin A Palmitate 0.01-5%, DEA-cetylphosphate 0.01-1%, Sodium Ascorbyl Phosphate 0.01-1%, Panthenol 0.01-1%, BHT (butyrated hydroxy toluene) It is a nanocapsule composition comprising 0.1 to 0.5% and purified water as balance.

The nanocapsule composition of the present invention is in the form of a nanocapsules of the above composition. The process of preparing nanocapsules is well known to those skilled in the art. For example, it can be prepared by dissolving the ingredients and contents as described above at a temperature of up to 80 ° C. and then mixing with a homo mixer and three successive passes under 1,000 bar in a high pressure homogenizer.

The nanocapsule composition of the present invention contains vitamins A, B5, C, E, silk amino acids, DEA-cetyl phosphate and BHT in the nanocapsule and is useful for use as a cosmetic. Since the nanocapsules include both hydrophobic materials as well as water-soluble materials, low cost can be used to prepare cosmetics having excellent effects.

Accordingly, the present invention also provides a cosmetic comprising the nanocapsule composition described above.

Examples of cosmetics of the present invention include, but are not limited to, body lotion, shampoo and rinse. In the cosmetic of the present invention, it is preferable to contain 0.1 to 10% of the nanocapsule composition.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, these examples are for illustrative purposes only and the scope of the present invention is not limited to these examples.

Example 1 Preparation of Nanocapsules

(1) Materials and Contents Used to Make Nanocapsules

Unsaturated Lecithin (Phosphopatarcholine) 3%

Ethanol 10%

Sucrose Stearate 1%

Capric / Caprylic Triglycerides 5%

Silk Amino Acid 20.00%

Tocopherol Acetate 5%

Vitamin A Palmitate 1%

DEA-cetylphosphate 0.03%

Sodium Ascorbyl Phosphate 0.05%

BHT 0.10%

100% fit with purified water

(2) Preparation of Nanocapsules

The material was introduced into a container and dissolved at a temperature of 80 ° C., and then mixed for 5 minutes using a homo mixer, passed three times at 1,000 bar in a high pressure homogenizer, and then cooled and defoamed to obtain nanocapsules. The particle size distribution was measured for the obtained nanocapsules. The particle size distribution was measured using a Malvern Zetasizer 1000HS (Malvern, UK).

1 is a view showing the particle size distribution of the nanocapsules prepared in this embodiment. As shown in FIG. 1, the particle size was mostly distributed in the range of 200 to 300 nm.

In addition, the nanocapsules obtained in this example were observed with a freez-fracture scanning electron microscope. 2 is a view showing the results of observing the nano-capsules obtained in this example with a freeze-fracture scanning electron microscope. In FIG. 2, the protruding portion in a round shape is a nanocapsule portion which is a monolayer, and the portion recessed in a round shape is a liposome portion which represents a lipid bilayer.

Example  2: Preparation of Nano Capsule

In Example 1, except that the content of sucrose stearate was set to 0.5%, the nanocapsules were prepared in the same amount as in Example 1, and the particle size distribution was measured.

As a result of the measurement, it was confirmed that the size distribution similar to Example 1.

Example  3: Preparation of Nano Capsule

In Example 1, except that the content of sucrose stearate was set to 0.1% to the same content as in Example 1 to prepare a nanocapsules, the particle size distribution was measured.

As a result of the measurement, it was confirmed that the size distribution similar to Example 1.

Example  4: nano capsule body  Lotion

(1) Substances and contents used in the manufacture of body lotions

(a)

Polyglycerol-3 Methyl Glucose Distearate 2.00%

Dicaprylic Carbonate 3.00%

Capric / Caprylic Triglycerides 2.00%

Sukualan 5.00%

Macadamia Nut Oil 5.00%

(b)

Glycerin 8.00%

Purified Water 69%

(c) Sepigel 305 (polyacrylamide / C13-14 isoparaffin / laures-7) 1.00%

(d) Nano capsule 5.00%

(2) manufacture of body lotion

(A) and (b) were injected into a container, and the components were dissolved at 80 ° C. and emulsified with a homomixer for 10 minutes, followed by the addition of (c) at 60 ° C., followed by thickening to add component (d) at 40 ° C. After cooling, a body lotion was obtained.

(3) Confirmation of the effect of the body lotion prepared in this example

The body lotion obtained in this example was applied to the forearm region of the test subject three times at 6 hour intervals for 2 days. Two weeks later, the body lotion was photographed with an image analyzer to observe the state. As a control, a body lotion prepared by the same process was used except for the nanocapsules of the present invention in the process of preparing the body lotion. 3 is a view showing the results of the image analysis observed two weeks after applying the body lotion. As shown in FIG. 3, when the body lotion including the nanocapsules of the present invention was applied, it was found that coarse keratin disappeared. In Figure 3, A is the case of using a control body lotion, B is a case of using a body lotion comprising the nanocapsules of the present invention.

In addition, as described above, after 2 weeks of body lotion, the moisture content of the body lotion was measured by Corneometer CM820 (C + K, swiss) to investigate the effect of the nanocapsules of the present invention on skin moisturizing ability. It was. 4 is a view showing the moisture content observed after 2 weeks in the body lotion. As shown in Figure 4, when using the body lotion containing the nanocapsules of the present invention was significantly higher moisture content than the control.

Example  5: nano capsule Sampu  Produce

(1) Substances and contents used in the preparation of Shampoo

a) Balanced purified water to 100% total.

NaCl 1.00%

EDTA 0.10%

Citric acid 0.04%

Propylene Glycol 3.00%

b) sodium lauryl sulfite (SDS) 40.00%

Coco fatty acid dietholamide 2.00%

Cocoamidepropyl betaine 3.00%

c) polymer (polyacrylamide) 0.40%

Purified water 20.00%

d) incense 0.40%

Nano Capsule 10.00%

(2) manufacturing process

The polymer of c) was wetted in purified water using a stirring mixer, a) the phase was added to the mixer to dissolve at 75 ° C, b) the phase was mixed with stirring for 10 minutes by a mixer, and then c) phase at 60 ° C. After the addition and thickening, the ingredient d) was added at 40 ° C. and then cooled to obtain a shampoo.

(3) Confirmation of the effect of shampoo prepared in this example

Five random women were selected as test subjects, and the shampoos prepared in this Example were used as usual for two weeks, and then the hair conditioning effect was examined. The sampu used in the experiment is the sampu prepared in this example (containing 5% nanocapsules) (experimental group), the sampu manufactured in the same manner as the experimental group sampuu except that it is prepared by adding the same amount of purified water instead of nanocapsules. (Control 1), and Shampoo (Control 2) prepared in the same manner as the experimental Sampew except that it contained 5% of dimethylsiloxane (also called dimethicone) instead of the nanocapsules.

The hair conditioning effect was evaluated in two ways: wet and dry. Evaluation criteria were expressed by the subject subjects after the subjective points were given according to the evaluation criteria as shown in Table 1 below, and averaged.

Table 1. Evaluation Criteria for Hair Conditioning Effects

Wet grade Dry Very smooth 5 Very smooth Smooth 4 Smooth is average 3 is average It takes a little bit of hand 2 It takes a little bit of hand Take badly in my hand One Take badly in my hand

The evaluation results are shown in Table 2 below.

Table 2. Evaluation Results

division Control group 1 Control 2 Experimental group Wet 3.2 3.5 3.9 Dry 2.4 3.2 4.5

As shown in Table 2, it was investigated that the hair conditioning effect of Sampew including the nanocapsules of the present invention is excellent.

Example  6: Preparation of Rinse Using Nano Capsule

(1) Substances and contents used in the preparation of the rinse

a) ceteallyl alcohol 0.50%

Stearyl alcohol0.50%

Cetanol 1.00%

b) EDTA 0.05%

PEG-6000 1.00%

Water Soluble Silicone 1.00%

Distearyl-dimethyl ammonium chloride 2.00%

Cetyl-trimethyl-ammonium chloride 2.00%

100% purified water

c) polymer (polyacrylamide) 0.20%

d) 10.00% of nanocapsules

(2) manufacturing process

The polymer of c) was moistened in a suitable amount of purified water using a stirring mixer, and a) the phase was added to the mixer to dissolve at 80 ° C, and b) the phase heated to 80 ° C was added and stirred for 10 minutes with a homomixer to homogenize. After mixing, the c) phase was added at 60 DEG C, followed by thickening followed by the addition of the d) component at 40 DEG C, followed by cooling to obtain a rinse.

(3) Confirmation of the effect of the rinse prepared in this example

The effect of the nanocapsules of the present invention on the moisturizing effect of the hair was investigated using the rinse prepared in this example. The measurement of hair moisture was measured as follows. First, a hairdresser having a length of 10 cm and a weight of 1 g was made, and each of the following rinses was dropped 0.3 g and rubbed five to six times with the same force, followed by rinsing with tap water three times with the same force. Next, it was dried for 2 hours at a temperature of 50 ℃. The dried hairdresser was left for 24 hours at a temperature of 25 ° C. and a relative humidity of 70%. Next, the hairdresser was cut out, and the middle portion 2 cm and 0.15 g were taken, and the water content was measured five times using a Karl fischer moisture titrator (784 KFP TITRINO +768 KF OVEN; Metrohm). As for measurement conditions, the nitrogen gas flow rate was 90 ml / min, the extraction time was 2,000 second, and the temperature was 150 degreeC. The rinse used was the same as the rinse of the present invention except that the same amount of purified water was added instead of the rinse containing the 5% nanocapsules prepared in this example and nanocapsules. The results of measuring the moisture content are shown in Table 3. As shown in Table 3, when the rinse containing the nanocapsules of the present invention was used, the moisture content was high.

Control Experimental group Hair moisture (%) 10.20 11.20

From the results of the above examples, capric / caprylic triglycerides, silk amino acids, tocopherol acetate, vitamin A palmitate, DEA-cetylphosphate, vitamin C, panthenol and the like using unsaturated lecithin, ethanol, and sucrose stearate Nanocapsules containing compounds useful for skin health such as BHT could be prepared. The nanocapsules produced had an effect of softening the skin and maintaining moisture content when the particle size distribution was 200-300 nm and used in the preparation of cosmetics such as lotions, shampoos and rinses.

6 cycles (1 week per cycle, total 6 weeks) in the circulation tank from -5 to 45 degrees for the stability showed a significant difference in particle size. Conventional capsules have a particle size of 100 nm for 500 cycles after 6 cycles (-5 degrees to 45 degrees), whereas for sucrose, 250 nm to 280 nm.

According to the nanocapsule composition of the present invention, it contains both hydrophilic and hydrophobic active ingredients that are stable and useful for skin health, and thus may be usefully used in cosmetics.

According to the cosmetic of the present invention, the skin can be softened by maintaining the moisture content.

Claims (4)

Unsaturated lecithin 1-5%, ethanol 1-20%, sucrose stearate 0.1-1%, capric / caprylic triglyceride 1-5%, silk amino acids 1-20%, tocopherol acetate 1-20%, vitamin A Palmitate 0.01-5%, diethanolamine (DEA) -cetylphosphate 0.01-1%, vitamin C 0.01-1%, panthenol 0.01-1%, BHT (butyrated hydroxy toluene) 0.1-0.5% and purified water as balance Nano capsule composition. Cosmetics containing the nanocapsule composition of claim 1. The cosmetic according to claim 2, which is a body lotion, shampoo or rinse. The cosmetic according to claim 2, which comprises 0.1 to 10% of the nanocapsule composition.

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