KR102500905B1 - Translucent nanoemulsion containing natural ceramide and cosmetic composition including the same - Google Patents

Abstract

The present invention relates to a nanoemulsion of a translucent formulation containing natural ceramide and a cosmetic composition including the same. It is a semi-transparent formulation distributed in small particles with a particle size of 40 ~ 80 nm, and is formulated into an emulsion stably without precipitation. When included in a cosmetic composition, it improves skin delivery and adhesion and recovers excellent skin barrier. Provided are a nanoemulsion of a translucent formulation exhibiting effects and moisturizing power, and a cosmetic composition including the same.

Description

Translucent nanoemulsion containing natural ceramide and cosmetic composition including the same

The present invention relates to a nanoemulsion of a translucent formulation containing natural ceramide and a cosmetic composition including the same, and more particularly, to a high content of natural ceramide, a poorly soluble substance, in a translucent formulation using a fatty acid, an ionic surfactant, and an oil. It relates to a nanoemulsion and a cosmetic composition containing the nanoemulsion.

In general, the skin barrier is composed of a phospholipid structure that prevents bacteria or viruses from entering from the outside to protect the skin and at the same time selectively absorbs necessary substances. mortar model'. Here, bricks correspond to keratinocytes, and concrete corresponds to lipids between keratinocytes, which are various lipid complexes, and form an overlapping structure rather than a single layer, so that external foreign substances, bacteria, and moisture are difficult to penetrate. Ceramide is the main component of lipids between keratinocytes that plays a very important role in this skin barrier, preventing moisture loss and protecting it from external harmful environments and pollution. Skin that lacks ceramide quickly evaporates moisture in the skin, resulting in dryness that causes cracks in the skin or peeling of the skin texture.

Natural ceramide is a type of sphingolipid that has a structure in which fatty acids are linked to sphingosine. It has the ability to maintain an orderly structure. Therefore, many studies are known that applying a formulation containing natural ceramide to the skin helps in skin barrier function and skin moisturizing. However, it is difficult to mass-produce natural ceramides due to difficulties in extraction, and the price of raw materials is also expensive, so it is difficult to produce them as products. Ceramide was extracted from bovine brain and used since the 1990s, but since the use of animal products was banned, sugar ceramides extracted from plants or ceramide NP and ceramide NS developed through yeast fermentation have been mainly used. Various ceramides exist due to the structure of fatty acids that bind to ceramide precursors, sphingoids and polar head groups (R). Among them, ceramides combined with phytosphingosine include ceramide NP, AP, EOP, etc., and those combined with sphingosine are called ceramide NS, AS, EOS, etc. Each of these ceramides plays an important role, mainly forming a skin barrier, absorbing moisture, and protecting the skin.

Ceramide production methods include extraction, yeast fermentation, and pseudoceramide synthesis. It is extracted from plants such as soybean, wheat, and rice, and exists in the form of glycated ceramide, but the amount is insignificant. After preparing a precursor using an enzyme, fatty acids are synthesized It is the main method of natural ceramide currently on the market as a manufacturing method of combining. Pseudoceramides have a structure similar to natural ceramides, but have low solubility due to their hydrophobicity, so they are easy to apply and price competitive, and have the advantage of showing similar functions in terms of moisturizing effect, but have the disadvantage of causing skin irritation or poor skin compatibility. (Kwon Min-soo, Comparative Study on Skin Moisturizing Effect and Barrier Function of Natural Ceramide and Pseudo-ceramide, Konkuk University Graduate School, 2005)

On the other hand, natural ceramide is a poorly soluble substance with a melting point of over 100 ° C. Due to its structural characteristics, when it is contained in a large amount in cosmetics, it crystallizes and precipitates. In formulations with fluidity such as lotion or transparent skin, high content of ceramide cannot be used.

As a prior art for solving these problems, Korean Patent Publication No. 10-2017-0038249 (Reference 1), Korean Patent Publication No. 10-2019-0088920 (Reference 2), Republic of Korea Patent Registration No. 10-1473198 ( Reference 3) and Korean Patent Registration No. 10-1837433 (Reference 4) have been proposed.

Reference 1 relates to a high-content ceramide nanoemulsion with improved transparency, a cosmetic composition containing the same, and a manufacturing method thereof, including ionic surfactants, polyols, ethanol, and silicone oil, which are prepared by high-pressure emulsification to realize stability However, it is difficult to see that it can have the same effect or stability as natural ceramide because it uses highly irritating ethanol in cosmetics and has been developed as a similar ceramide with a low melting point rather than natural ceramide.

And Reference 2 relates to a cosmetic composition containing particles containing a high content of ceramide and a method for producing the same, which uses phytosphingosine to have a multilayer lamellar structure so that a high content of ceramide is not precipitated, and the particles are It is large and has a rough surface, so it can only be applied to lotions or creams, and there are limitations in transparent formulations or non-viscous skin formulations.

In addition, Reference 3 relates to a cosmetic composition containing a transparent ceramide emulsion, which contains ceramide in a transparent formulation using lecithin, medium chain triglyceride, glycerin and an anionic surfactant, and has a limit of applying up to 5% of ceramide. , the particle size is also more than 80nm, and it is inferior in terms of stability and skin absorption to those manufactured with less than 80nm.

And Reference 4 relates to a nanoemulsion containing oil-soluble ingredients, a method for preparing the same, and a cosmetic composition including the same, including inulin lauryl carbamate as a surfactant and sodium surpectin as a stabilizer to contain a high content of ceramide. However, although the stability of the composition itself is excellent, it is a milky white formulation with a particle size of 100 to 200 nm, and has limitations in terms of skin penetration, and it is difficult to use in a transparent formulation.

Therefore, there is a need to develop a technology capable of stabilizing a cosmetic composition containing a translucent high content of ceramide by overcoming the limitations of these prior arts.

Reference 1: Korean Patent Publication No. 10-2017-0038249 Reference 2: Korean Patent Publication No. 10-2019-0088920 Reference 3: Korean Patent Registration No. 10-1473198 Reference 4: Korean Patent Registration No. 10-1837433

Therefore, the present invention to solve such problems of the prior art is a translucent formulation distributed in nanoparticles while containing natural ceramide, stably formulated into an emulsion without precipitation, thereby improving skin transmission and adhesion, and providing excellent skin An object of the present invention is to provide a nanoemulsion exhibiting a barrier recovery effect and moisturizing power, and a cosmetic composition including the same.

In particular, the present invention is a translucent nanoemulsion formulation with a particle size of 40 to 80 nm to develop a cosmetic composition that improves the problem of precipitation or gelation in the case of a composition containing a high content of natural ceramide, enhancing skin barrier function and improving moisture retention. The purpose is to provide a nanoemulsion and a cosmetic composition including the nanoemulsion that can be stably maintained for a long time without precipitation at the same time as exhibiting the effect of giving.

The present invention to solve such a technical problem;

A nanoemulsion of a translucent formulation containing a high content of natural ceramide is formed, but contains 1.0 to 10.0% by weight of natural ceramide, 0.1 to 5.0% by weight of ionic surfactant and 0.1 to 5.0% by weight of fatty acid based on the total weight of the nanoemulsion. It provides a nanoemulsion of a translucent formulation containing natural ceramide, characterized in that.

At this time, the mixture containing the natural ceramide, ionic surfactant, and fatty acid is passed through a high-pressure homogenizer (Microfluidizer) so that the ceramide is evenly dispersed without precipitation, so that the nanoemulsion has a particle size of 40 to 80 nm.

In particular, the nanoemulsion is glycerin 45% by weight, pentylene glycol 2.0% by weight, sodium stearoyl glutamate 1.0% by weight, octyldodecanol 10.0% by weight, hydrogenated poly (C6-14 olefin) 5.0% by weight, ole It is characterized by consisting of 2.0% by weight of Iksan, 5.0% by weight of natural ceramide and 30.0% by weight of purified water.

And the present invention also provides a cosmetic composition characterized in that it contains 0.01 to 20% by weight of the nanoemulsion based on the total weight of the cosmetic composition.

At this time, the cosmetic composition is characterized by having any one formulation selected from the group consisting of lotion, lotion, essence, cream, hair tojik, hair conditioner, shampoo, rinse, lotion for infants and young children, cream, wet tissue, and sheet mask.

The nanoemulsion of a translucent formulation containing natural ceramide according to the present invention is a translucent nanoemulsion containing a high content of ceramide in a translucent formulation that can strengthen the skin barrier and enhance moisturizing power, and is distributed in small particles with a particle size of 40 to 80 nm. By formulating it into an emulsion stably without precipitation into the formulation, when it is included in the cosmetic composition, it has the effect of improving skin transmission and adhesion, and exhibiting excellent skin barrier recovery effect and moisturizing power.

Figure 1 is a photograph showing the stability results by temperature of Examples 1 to 3 and Comparative Examples 1 to 4 of the nanoemulsion of a translucent formulation containing natural ceramide according to the present invention.
Figure 2 is a particle distribution graph of Examples 1 to 3 and Comparative Examples 2 and 4 of the nanoemulsion of a translucent formulation containing natural ceramide according to the present invention.
Figure 3 is a graph comparing the skin moisturizing effect of Example 4 and Comparative Examples 5 and 6 of the cosmetic composition containing the nanoemulsion of a translucent formulation containing natural ceramide according to the present invention.

Hereinafter, the characteristics of the nanoemulsion of a translucent formulation containing natural ceramide and the cosmetic composition including the nanoemulsion according to the present invention will be understood by examples described in detail with reference to the accompanying drawings.

Since the present invention can have various changes and various forms, the embodiments will be described in detail in the text. However, this is not intended to limit the present invention to a specific form disclosed, and should be understood to include all modifications, equivalents, or substitutes included in the spirit and scope of the present invention.

The translucent formulation nanoemulsion containing natural ceramide according to the present invention has natural ceramide, ionic surfactant, polyol and fatty acid as main components, and is prepared by further mixing with oil and then emulsifying under high pressure.

The nanoemulsion of the translucent formulation containing natural ceramide according to the present invention includes 1.0 to 10.0% by weight of natural ceramide, 0.1 to 5.0% by weight of ionic surfactant, and 0.1 to 5.0% by weight of fatty acid based on the total weight of the nanoemulsion. . In addition, the oil may further include 5.0 to 30.0% by weight of ester-based oil and 5.0 to 30.0% by weight of hydrocarbon-based oil.

Hereinafter, the present invention will be described in detail. Since these examples are only for illustrating the present invention, the scope of the present invention is not limited by these examples.

First of all, the ceramide is the same natural ceramide as the human body obtained through yeast fermentation, and is structurally different from similar ceramides made by synthesizing fatty acids and cholesterol, and has different physical properties such as melting point and hydrophobicity, so natural ceramide is more difficult to stabilize with nanoemulsion. There is a difficulty. The structure of the natural ceramide NP and the structure of the pseudoceramide (Ceramide PC-104) are as follows [Structure of the natural ceramide NP] and [Structure of the pseudoceramide (Ceramide PC-104)].

[Structure of natural ceramide NP] [Structure of pseudoceramide (Ceramide PC-104)]

These natural ceramides are preferably contained in an amount of 0.1% to 10.0% by weight based on the total weight of the emulsion. If it is less than 0.1%, it has the disadvantage of insufficient efficacy, and if it contains more than 10%, it is difficult to obtain satisfactory efficacy because the stability of the formulation is very unstable or there is a phenomenon of precipitation.

And the ionic surfactant is Sodium Stearoyl Glutamate, Sodium Lauryl Glutamate, Potassium Cetyl Phosphate, Glyceryl Stearate Citrate , Distearyl Dimonium Chloride may be used alone or two or more selected from the group consisting of, and more preferably, Sodium Stearoyl Glutamate may be used.

These ionic surfactants are preferably contained in an amount of 0.1 to 5.0% by weight based on the total weight of the emulsion. If it is included in less than 0.1% by weight, the stabilizing effect may not be achieved when applied as a cosmetic formulation, so particle formation may not be achieved, and if it exceeds 5.0% by weight, irritation occurs to the skin, so it is preferable to adjust it appropriately within the above range.

In addition, the polyol is to improve the stability of the formulation by adjusting the refractive index of the formulation to increase transparency and lower the freezing point, glycerin, 1,3-butylene glycol (1,3-Butylene Glycol), propylene glycol ( Propylene Glycol), Pentylene glycol, Propanediol, Methyl Propanediol, and Dipropylene Glycol can be used alone or by selecting one or more. , It is preferably contained within the range of 10.0 to 70.0% by weight relative to the total weight of the emulsion. When included in less than 20% by weight, the high content of ceramide is limited in solubilization, and when it exceeds 70% by weight, the content of the emulsifier or lipid component is reduced, so that an appropriate blending ratio cannot be contained.

In addition, hydrocarbon-based oils, ester-based synthetic oils, mineral oils, vegetable oils, alkyl ester-based oils, and caprylic/capric triglyceride-based oils commonly used in this field may be used as the oil. Representatively, hydrocarbon-based oils including squalane, hydrogenated poly(C6-14 olefin) and octyldodecanol; Cetylethylhexanoate, isopropyl myristate, isopropyl palmitate, ethylhexyl palmitate, isononyl isononanoate, C12-15 alkyl benzoate, glyceryl trioctanoate, octyldodecyl myristate, octyl palmyate One selected from the group consisting of ester-based synthetic oils containing tate and mixtures thereof may be used.

The oil composition of the present invention is used by mixing octyldodecanol and hydrogenated poly(C6-14 olefin). It is preferably contained within the range of 5.0 to 30.0% by weight based on the total weight of the emulsion. If it is included in less than 5.0% by weight, it is difficult to dissolve a high content of ceramide, and if it exceeds 30.0% by weight, the amount of oil phase increases and the emulsifier content also increases, which may reduce the feeling of use or stability.

And the fatty acids may be used alone or at least one selected from the group consisting of lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linolic acid and behenic acid, and The fatty acid composition used isostearic acid. It is preferably contained within the range of 1.0% by weight to 10.0% by weight based on the total weight of the emulsion. If it is less than 1.0% by weight, it is difficult to form emulsified particles, and if it is more than 10.0% by weight, it is easy to cause skin irritation.

An optimal embodiment of the nanoemulsion of a translucent formulation containing natural ceramide according to the present invention is 45% by weight of glycerin, 2.0% by weight of pentylene glycol, 1.0% by weight of sodium stearoyl glutamate, 10.0% by weight of octyldodecanol, It is composed of 5.0% by weight of hydrogenated poly (C6-14 olefin), 2.0% by weight of oleic acid, 5.0% by weight of natural ceramide, and 30.0% by weight of purified water. This is the same as the content of Example 2 of [Table 1] described later.

The particle size of the nanoemulsion containing a high content of ceramide according to the present invention is preferably 40 to 80 nm. If the particle size is less than 40 nm, it is difficult to achieve in the manufacturing process, and if the particle size exceeds 80 nm, the translucency is lowered and the formulation stability is lowered due to the possibility of precipitation.

In this case, the nanoemulsion containing a high content of ceramide according to the present invention may contain 0.1 to 20% by weight as an active ingredient in the total weight (based on 100% by weight) of the total cosmetic composition applied, but is not limited thereto. If the mixture is included in less than 0.1% by weight, it may not affect the efficacy, and if it is included in more than 20% by weight, it may make the cosmetic formulation unstable.

The nanoemulsion containing high content ceramide according to the present invention is used for products for infants and young children, products for washing the human body (foam cleanser, body cleanser, etc.), eye makeup, hair dyeing, color makeup (makeup base, lip gloss, etc.), hair (hair tonic, shampoo, rinse, etc.) and basic cosmetics (lotion, essence, lotion, etc.) , shampoo, conditioner, lotion for infants and young children, cream, wet tissue, and sheet mask.

[Example]

Hereinafter, the contents of the present invention will be described in more detail through Examples and Comparative Examples.

- Examples 1 to 3 and Comparative Examples 1 to 4: Preparation of high-content ceramide nanoemulsion according to composition ratio

The following [Table 1] shows the blending ratio of Examples 1 to 3 and Comparative Examples 1 to 4 of the nanoemulsion of a translucent formulation containing natural ceramide according to the present invention. The emulsion manufacturing process is purified water and glycerin using a vacuum tank After completely dissolving sodium stearoyl glutamate at 30 rpm using a paddle mixer at 80 ° C, hydrogenated poly (C6-14 olefin), octyldodecanol, ceramide NP, and oleic acid were dissolved in a separate dissolution tank at 85 ° C. After putting it into a vacuum tank, it is stirred at 1000rmp.

Since this dissolved liquid is unstable in the form of irregular vesicles, it must pass through a high-pressure homogenizer to homogeneously and stably make fine particles. At this time, the most preferable conditions are a treatment temperature of 30 to 70 ° C and a passage pressure in the range of 5,000 to 20,000 Psi. The number of passes is suitable from 1 to 10, but preferably from 3 to 5, the most homogeneous and stable nanoemulsion is formed.

division Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 glycerin 45.0 45.0 35.0 45.0 45.0 35.0 35.0 pentylene glycol 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Sodium Stearoyl Glutamate 0.5 1.0 2.0 0.5 2.0 Octyldodecanol 10.0 15.0 15.0 15.0 Hydrogenated poly (C6-14 olefin) 10.0 5.0 5.0 10.0 10.0 5.0 5.0 oleic acid 0.5 2.0 3.0 0.5 3.0 ceramide 1.0 5.0 10.0 1.0 1.0 10.0 10.0 Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 appearance translucent liquid translucent
gel phase translucent gel separation translucent
liquid separation translucent
gel phase M/F processing O O O O O O O

In Table 1, Examples 1 to 3 and Comparative Examples 2 and 4 were obtained by adjusting the contents of sodium stearoyl glutamate and oleic acid at various concentrations from 1.0 to 10.0% by weight of ceramide, and translucent properties were obtained through a high-pressure homogenizer. In Comparative Examples 1 and 3, when sodium stearoyl glutamate, the main emulsifying agent, was removed, unstable emulsification was immediately separated.

- Test Example 1: Item-by-item test of high-content ceramide nanoemulsion

Samples were taken immediately after preparation of the emulsions prepared in Examples and Comparative Examples to confirm the emulsion average particle size and the stability of the nanoemulsion over time, and are shown in [Table 2]. In order to measure the average particle size of the emulsion, it was measured using a nanoparticle analyzer (SZ-100Z, Horiba Co.) capable of measuring particle size and zeta potential using dynamic light scattering characteristics. In addition, in order to examine the stability of the nanoemulsion over time, the samples prepared in Examples 1 to 3 and Comparative Examples 1 to 4 were subjected to room temperature, refrigeration (2 ℃), high temperature (45 ℃) freezing (-17 ℃) In 4 weeks, discoloration, separation, suspension, and precipitation were evaluated by visually observing and recording.

division particle
size zeta
potential Change over temperature of the nanoemulsion prepared in Examples 1 to 3 and Comparative Examples 1 to 4 High temperature (45℃) Refrigeration (2℃) Frozen (-17℃) room temperature 1 week 2 weeks 4 weeks 1 week 2 weeks 4 weeks 1 week 2 weeks 4 weeks 1 week 2 weeks 4 weeks Example 1 51.7 -136.4 ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ Example 2 74.6 -145.0 ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ Example 3 61.6 -97.9 ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ ○ Comparative Example 1 - -10.4 X X X X X X X X X X X X Comparative Example 2 123.6 -61.2 ○ ○ ○ ○ ○ ▽ ○ ▽ ▽ ○ ○ ○ Comparative Example 3 - -15.3 ▽ ▽ ▽ ▽ ▽ ▽ ▽ ▽ ▽ ▽ ▽ ▽ Comparative Example 4 142.7 -52.5 ○ ○ ▼ ○ ○ ▽ ○ ▽ ▽ ○ ○ ○

(○: Good, X: Separation, ▼: Off-odor, ▽: Suspension and precipitation)

Looking at the results in [Table 2], as can be seen from the comparison between Example 1 and Comparative Examples 1 and 2, Comparative Example 1, which did not contain sodium stearoyl glutamate, showed a separation phenomenon immediately after emulsification. In Comparative Example 2, a relatively stable nanoemulsion was formed with a particle size of 123.6 nm and a zeta potential of -61.2 mV, but as a result of observation in a refrigerator for 4 weeks, a suspension phenomenon occurred, indicating an unstable state. On the other hand, Example 1 formed a very stable emulsion with a particle size of 51.7 nm and a zeta potential of -136.4 mV, and all were stable as a result of observing the stability for 4 weeks. In addition, as can be seen from the comparison between Example 3 and Comparative Examples 3 and 4, Comparative Example 3 in which sodium stearoyl glutamate was deleted while containing a high content of ceramide 10% showed the same results as Comparative Example 1, and oleic acid In Comparative Example 4, which was deleted, a phenomenon in which most of the ceramide was precipitated without forming emulsified particles as in Comparative Example 2 occurred. The particle analysis results of Examples 1 to 3 and Comparative Examples 1 to 4 and the stability results at each temperature condition are shown in FIGS. 1 and 2.

Through these results, when sodium stearoyl glutamate was used alone as a surfactant, the particle size and zeta potential were relatively good immediately after preparation, but suspension or precipitation occurred at low temperatures over time, but it could be mixed with fatty acids such as oleic acid. In this case, the nanoemulsion with excellent long-term stability can be prepared because the particles of the inner phase are formed very small and the particle size distribution is formed uniformly due to the selective orientation of fatty acids and surfactants.

- Example 4 and Comparative Examples 5 to 6: Preparation of the nanoemulsion-containing cream and general cream of Example 2

The following [Table 3] relates to the mixing ratio of Example 4, which is the cream containing the nanoemulsion of Example 2, and Comparative Examples 5 to 6, which relate to general creams.

ingredient name Example 4 Comparative Example 5 Comparative Example 6 Purified water To 100 To 100 To 100 Butylene Glycol 7.0 pentylene glycol 3.0 3.2 3.2 Disodium EDTA 0.02 allantoin 0.10 Polyglyceryl-13/Polyisobutene/Polysorbate 20 1.0 Example 2 Nanoemulsion 10.0 glycerin 4.5 4.5 oleic acid 0.2 0.2 Octyldodecanol 0.5 0.5 Hydrogenated poly (C6-14 olefin) 1.0 1.0 Ceramide NP 0.5

Among the cosmetic compositions of [Table 3], in the manufacturing method of Example 4 (the cream containing the nanoemulsion of Example 2), purified water was dissolved in allantoin, and then polyglyceryl-13/polyisobutene/polysorbate 20 was slowly added. while stirring with an azimixer. After the gel-like viscosity is formed, the nanoemulsion of Example 2 is added, stirred again, and then defoamed to complete. Comparative Example 4 was prepared as a general emulsion, not nanoparticles, by adding the raw material composition ratio of the nanoemulsion of Example 2, and the particle size, viscosity, and feeling of use were different. The manufacturing method is to completely dissolve purified water to allantoin in a water phase dissolution tank, heat it to 80℃, then put glycerin to ceramide NP into a separate melting tank and heat it to 85℃ to completely dissolve it. 1st stirring for 5 minutes. When the stirring is finished, polyglyceryl-13/polyisobutene/polysorbate 20 is slowly added again while stirring for 10 minutes. The manufacturing method of Comparative Example 5 is the same as Comparative Example 4 except for ceramide NP.

-Test Example 2: Confirmation of skin moisturizing effect

In order to confirm the skin moisturizing effect for Example 4 and Comparative Examples 5 and 6 obtained as a composition in the form of a milky lotion, the change in skin moisture content over time after application of the product was measured. The skin moisture content of 5 adult females and 5 males with an average age of 29.1 years was measured before application of the product, immediately after application, and over time using a Corneometer. Specifically, after washing the test site with lukewarm water 30 minutes before the test, after waiting for 10 minutes in a constant temperature and humidity room (22 ± 2 ° C, 40 to 60% RH), the skin moisture level at the time of no application of the test site was measured. In addition, after the test product was applied to the test site, the skin moisture level was measured immediately after application of the product, 2 hours later, and 8 hours later. The unit is A.U., which is a unit constant, and the skin moisturizing amount and measured value are proportional. The measured values represent the average of three times.

The following [Table 4] shows the results of measuring the skin moisture content of Example 4 and Comparative Examples 5 and 6 before, immediately after, 2 hours and 8 hours after application.

test product before use right after application 2 hours 8 hours uncoated 18.124±2.45 18.425±6.54 19.455±4.22 19.12±1.78 Example 4 18.567±5.42 59.978±4.83 45.157±6.41 32.421±6.69 Comparative Example 5 19.457±4.23 55.143±5.78 32.412±7.45 25.102±5.25 Comparative Example 6 20.986±5.68 50.535±2.41 29.365±7.71 21.681±7.16

Example 4, Comparative Examples 5 and 6 before application, immediately after application, after 2 hours, after 8 hours, as a result of measuring skin moisture, as shown in [Table 4] and FIG. 3, skin moisture immediately after application was Example 4 , Comparative Examples 5 and 6 increased compared to before application, but Comparative Example 6, which does not contain ceramide known to be effective in moisturizing, shows a rapid water loss immediately after application, whereas Example 4 and Comparative Example containing ceramide In Example 5, it was confirmed that the moisture content of the skin was maintained at a high level while the moisture evaporated slowly. In particular, it was found that Example 4, in which ceramide was stabilized with a nanoemulsion, had a higher skin moisture level than Comparative Example 5 immediately after application, and the skin moisture level was maintained higher than that of Comparative Example 5 even after 8 hours of application.

In the present invention, the cosmetic composition can be prepared as an emulsion, suspension, solution, oil-in-water (O/W type), and water-in-oil (W/O) type, for example, and among cosmetic types set by the Ministry of Food and Drug Safety, products for infants and young children , body cleansing products (foam cleanser, body cleanser, etc.), eye makeup, hair dyeing, color makeup (makeup base, lip gloss, etc.), hair use (hair tonic, shampoo, conditioner, etc.), basic makeup (toilet, Essence, lotion, etc.) can be any one selected from products, preferably astringent / softening / nourishing lotion, lotion, essence, cream, hair tojik, hair conditioner, shampoo, rinse, lotion for infants and young children, cream, wet tissue, sheet Preferably used in one or more formulations selected from the group consisting of masks.

The cosmetic composition of the present invention may be mixed and prepared in the ingredient ratios as shown in [Table 5] to [Table 8] below.

First of all, [Table 5] shows the component ratio when the softening lotion (Example 5) was prepared using the nanoemulsion of Example 2 prepared as described above.

number ingredient Example 5 function One Purified water To 100 solvent 2 Disodium EDTA 0.01 sequestering agent 3 Butylene Glycol 8.00 moisturizer 4 glycerin 5.00 moisturizer 5 1,3-propanediol 7.00 moisturizer 6 allantoin 0.10 skin conditioning agent 7 carbomer 0.05 thickener 8 tromethamine 0.05 pH modifier 9 squalene 0.20 softener 10 Hydrogenated (C6-14 olefin) 0.10 softener 11 Tocopheryl Acetate 0.10 antioxidant 12 Ethylhexylglycerin 0.05 moisturizer 13 1,2-hexanediol 0.50 moisturizer 14 incense 0.10 flavoring agent 15 Example 2 Nanoemulsion 10.0 moisturizing, anti-wrinkle

In the softening lotion according to Example 5 of [Table 5], raw materials 1 to 6 were heated and mixed at 50° C., then raw materials 7 and 8 were sequentially introduced and stirred. After completely dissolving raw materials 9 to 14 in a separate melting tank, add raw material 15 at the end to uniformly disperse and mature for 1 day.

Next, [Table 6] shows the component ratio when preparing the lotion (Example 6) using the nanoemulsion of Example 2 prepared as above.

number ingredient Example 6 function One Purified water To 100 solvent 2 Disodium EDTA 0.01 sequestering agent 3 Butylene Glycol 8.00 moisturizer 4 glycerin 5.00 moisturizer 5 1,3-propanediol 3.00 moisturizer 6 Dipotassium glycyrrhizate 0.01 irritation reliever 7 carbomer 0.05 thickener 8 tromethamine 0.05 pH modifier 9 Cetostearyl Alcohol 1.50 softener 10 behenyl alcohol 1.20 softener 11 Polyglyceryl-3methylglucose distearate 0.50 emulsifier 12 Hydrogenated Lecithin 0.20 emulsifier 11 Caprylic/Capric Triglyceride 1.00 preservative 13 squalane 0.50 softener 14 Neopentyl Glycol Diheptanoate 1.50 moisturizer 15 Hydrogenated poly(C6-14 olefin) 1.50 softener 16 Tocopheryl Acetate 0.20 antioxidant 17 1,2-hexanediol 2.00 moisturizer 18 Ethylhexylglycerin 0.05 moisturizer 19 incense 0.10 flavoring agent 20 Example 2 Nanoemulsion 10.0 moisturizing, anti-wrinkle

In the lotion according to Example 6 of [Table 6], raw materials 1 to 6 were warmed and mixed at 50° C., and then raw materials 7 and 8 were sequentially introduced and stirred. After completely dissolving raw materials 9 to 16 in a separate melting tank, add raw materials 17 to 20 at the end to uniformly disperse, and mature for 1 day.

And [Table 7] shows the component ratio when preparing a cream (Example 7) using the nanoemulsion of Example 2 prepared as above.

number ingredient Example 7 function One Purified water To 100 solvent 2 Disodium EDTA 0.01 sequestering agent 3 Butylene Glycol 8.00 moisturizer 4 glycerin 5.00 moisturizer 5 1,3-propanediol 0.07 thickener 6 Dipotassium glycyrrhizate 0.05 stimulant 7 carbomer 0.20 thickener 8 tromethamine 0.20 pH modifier 9 Cetostearyl Alcohol 3.00 softener 10 behenyl alcohol 2.00 softener 11 Glyceryl Monostearate 0.50 emulsifier 12 Hydrogenated Lecithin 1.00 emulsifier 11 Polyglyceryl-3methylglucose distearate 2.00 preservative 13 squalane 5.00 softener 14 Neopentyl Glycol Diheptanoate 3.00 moisturizer 15 Hydrogenated poly(C6-14 olefin) 3.00 softener 16 Tocopheryl Acetate 0.20 antioxidant 17 1,2-hexanediol 2.00 moisturizer 18 Ethylhexylglycerin 0.05 moisturizer 19 incense 0.20 flavoring agent 20 Example 3 (adenosine-containing ethosome base) 10.0 moisturizing, anti-wrinkle

In the cream according to Example 7 of [Table 7], raw materials 1 to 6 were heated and mixed at 50 ° C, and then raw materials 7 and 8 were added in order and stirred. After completely dissolving raw materials 9 to 16 in a separate melting tank, add raw materials 17 to 20 at the end to uniformly disperse, and mature for 1 day.

Although the embodiments of the present invention have been described in detail as described above, the scope of the present invention is not limited thereto, and the scope of the present invention extends to those within the scope substantially equivalent to the embodiments of the present invention.

Claims (5)

A nanoemulsion of a translucent formulation containing a high content of natural ceramide is formed, but contains 1.0 to 10.0% by weight of natural ceramide, 0.1 to 5.0% by weight of ionic surfactant and 0.1 to 5.0% by weight of fatty acid based on the total weight of the nanoemulsion. do;
The nanoemulsion is glycerin 45% by weight, pentylene glycol 2.0% by weight, sodium stearoyl glutamate 1.0% by weight, octyldodecanol 10.0% by weight, hydrogenated poly (C6-14 olefin) 5.0% by weight, oleic acid A nanoemulsion of a translucent formulation containing natural ceramide, characterized in that it is composed of 2.0% by weight, 5.0% by weight of natural ceramide and 30.0% by weight of purified water.
According to claim 1,
The mixture containing the natural ceramide, ionic surfactant, and fatty acid is passed through a high-pressure homogenizer (Microfluidizer) so that the ceramide is evenly dispersed without precipitation, so that the particle size of the nanoemulsion is formed to 40 to 80 nm. Natural ceramide, characterized in that Nanoemulsion of translucent formulation containing
A cosmetic composition comprising the nanoemulsion of claim 1 or 2 in an amount of 0.01 to 20% by weight based on the total weight of the cosmetic composition.
According to claim 3,
The cosmetic composition characterized in that it has any one formulation selected from the group consisting of lotion, lotion, essence, cream, hair tojik, hair conditioner, shampoo, rinse, lotion for infants and young children, cream, wet tissue, sheet mask .
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