KR102138733B1 - Cosmetic composition for wrinkle improvement containing phospholipid nano-structure - Google Patents

Abstract

The present invention relates to a cosmetic composition for ameliorating wrinkles to which a phospholipid nanostructure is applied, composed of 0.1-1 wt% of glutathione, 0.1-0.5 wt% of raspberry ketone, 5-10 wt% of saturated lecithin, 40-60 wt% of glycerin, an appropriate amount of neutralizing agent, an appropriate amount of hydrocarbon-based oil, other preservatives and an appropriate amount of conditioning raw materials, and a remaining amount of water. The present invention is effective in ameliorating wrinkles when a skin care composition in which the composition is partially applied is applied for a long time.

Description

Cosmetic composition for wrinkle improvement containing phospholipid nanostructures {COSMETIC COMPOSITION FOR WRINKLE IMPROVEMENT CONTAINING PHOSPHOLIPID NANO-STRUCTURE}

The present invention relates to a cosmetic composition for wrinkle improvement in which phospholipid nanostructures containing glutathione, raspberry ketone and saturated lecithin are applied, and more specifically, after dissolving glutathione in purified water, the remaining hydrophilic substances including glycerin and a neutralizing agent are mixed to obtain an aqueous phase. Making, dissolving raspberry ketone in a hydrocarbon-based oil at high temperature, mixing the remaining lipophilic substances including saturated lecithin to form an oil phase, putting an oil phase in the water phase and operating an azimuth to form a primary phospholipid nanostructure emulsion, , The primary emulsion relates to a cosmetic composition for improving wrinkles and a skin care composition using the phospholipid nanostructure, in which the particle size of the phospholipid nanostructure is made less than 100 nm through a high pressure emulsifier.

Currently, widely used as a cosmetic material for wrinkle improvement include vitamin A-related materials such as retinol and derivatives, DNA-related materials such as adenosine, and peptides such as Argireline and Matrixyl. However, most of these materials have two disadvantages, the first is that they are not chemically stable in the product, and the function of the active ingredient in the product is already destroyed before application to the skin. Even if it remains, the active ingredient cannot be absorbed by the skin barrier. Although the material development of cosmetic products for wrinkle improvement is continuously being conducted, research and development on skin absorption of the material is insufficient.

[Advanced technical literature]

[Patent Document]

Patent Publication No. 10-0829890, "A new retinol derivative, a method for manufacturing the same and a cosmetic composition for improving wrinkles comprising the same" and

Patent Publication No. 10-20190023916, "A cosmetic composition for preventing skin aging or improving skin wrinkles and a method for manufacturing the same".

Accordingly, in the present invention, the use period of the active ingredient in the product is secured by using glutathione and raspberry ketone, which are chemically stable materials in the product, and at the same time, the use period of the active ingredient is formed by forming a phospholipid nanostructure using saturated lecithin. It is to provide a cosmetic composition for improving wrinkles, which is additionally secured and facilitates skin permeation by making the oil particle size less than 100 nm through a high-pressure emulsifier, so that the cosmetic composition for improving wrinkles is effectively delivered into the skin.

In order to achieve the above object, the present invention provides 0.1 to 1% by weight of glutathione, 0.1 to 0.5% by weight of raspberry ketone, 5 to 10% by weight of saturated lecithin, 40 to 60% by weight of glycerin, and an appropriate amount of neutralizing agent to neutralize glutathione, raspberry ketone. Provided is a cosmetic composition for improving wrinkles applied with phospholipid nanostructures including phospholipid nanostructure particles of less than 100 nm composed of an appropriate amount of hydrocarbon-based oil to be dissolved, other preservatives and conditioning raw materials and a residual amount of water, and a skin care composition using the same.

The cosmetic composition of the present invention can stably and efficiently absorb glutathione and raspberry ketone into the skin and expect the wrinkle improvement effect of the skin.

1 is a photograph of the cosmetic composition of the present invention using JEM-F200 (TEM).
2 is a result of measuring the particle size of the cosmetic composition of the present invention using Photal ELSZ-1000.
3 is a result of measuring the zeta potential of the cosmetic composition of the present invention using Photal ELSZ-1000.

Hereinafter, the present invention will be described in more detail.

The present invention, based on 100% by weight of the total composition, 0.1 to 0.5% by weight of raspberry ketone, 5 to 10% by weight of saturated lecithin, 0.1 to 1% by weight of glutathione, 40 to 60% by weight of glycerin, 0.2 to 0.3% by weight of neutralizing agent , Hydrocarbon-based oil 8 to 12% by weight, preservatives 1 to 3% by weight and conditioning raw materials 4 to 6% by weight and residual water, raspberry ketone is liposomed by saturated lecithin to form a phospholipid nanostructure Provided is a cosmetic composition for improving wrinkles.

The glutathione used in the cosmetic composition of the present invention is a hydrophilic crystalline polypeptide present in cells, and plays an important role in redox reactions in almost all living organisms. The first cell was isolated in 1921, which contains glutamic acid and sulfur, and was named by synthesizing the initial letter of glutamic acid and the suffix -Thio, which means a sulfur compound. The cosmetic composition of the present invention contains glutathione 0.1 to 1% by weight. In the present invention, when glutathione is included in an amount of less than 0.1% by weight, the wrinkle improvement effect is reduced due to the anti-oxidant agent, and when it is included in an amount exceeding 1% by weight, the wrinkle improvement effect compared to the increased raw material amount is not visibly increased, which is not economically desirable.

The raspberry ketone used in the cosmetic composition of the present invention is an aromatic natural phenolic compound that can be extracted from raspberry, and its quantity is limited in order to obtain naturally, and it is usually a compound obtained by condensation reaction of acetone and 4-hydroxybenzaldehyde. Is synthesized through a hydrogenation reaction. Raspberry ketone contains phenol and has excellent antioxidant properties. The cosmetic composition of the present invention contains 0.1 to 0.5% by weight of raspberry ketone. In the present invention, when the raspberry ketone is included in an amount of less than 0.1% by weight, the wrinkle improvement effect is reduced due to the anti-oxidant agent, and when it is included in an amount of more than 0.5% by weight, the wrinkle improvement effect compared to the increased raw material amount is not visibly increased, which is not economically desirable.

The saturated lecithin used in the cosmetic composition of the present invention serves as a skeleton forming a phospholipid structure. The cosmetic composition of the present invention contains 5 to 10% by weight of saturated lecithin. In the present invention, when the saturated lecithin is included in an amount of less than 5% by weight, it is difficult to form a phospholipid structure, and when it is included in an amount of more than 10% by weight, it is difficult to secure productivity due to excessive viscosity.

Glycerin used in the cosmetic composition of the present invention is used as a moisturizing agent in a general cosmetic composition, but when reacted with saturated lecithin, one alcohol group of glycerin forms an phosphate bond with a phosphate molecule to form a phosphatidyl ester, and two fatty acids of the lipid molecule This glycerin and ester bond form phosphatidic acid, which serves to increase the stability of the phospholipid nanostructure. In the present invention, when glycerin is included in an amount of less than 40% by weight, it is difficult to secure stability starting with phosphatidyl ester formation, and when it is included in an amount of more than 60% by weight, there is excessive stickiness due to the properties of glycerin, which is not preferable to be applied to skin care compositions. .

The neutralizing agent used in the cosmetic composition of the present invention serves to minimize skin irritation by neutralizing glutathione, which is acidic when dissolved in water. The neutralizing agent may be at least one selected from the group consisting of arginine, sodium citrate, sodium hydroxide, potassium hydroxide, triethanolamine, tromethamine, and the like, preferably arginine. The neutralizing agent is used in an amount of 0.2 to 0.3% by weight based on 100% by weight of the total weight of the cosmetic composition, in a conventional amount for proper neutralization of the components in the cosmetic composition of the present invention.

The hydrocarbon-based oil used in the cosmetic composition of the present invention dissolves raspberry ketone and serves to include raspberry ketone inside the phospholipid nanostructure during emulsification. The hydrocarbon-based oil is cetyl ethyl hexanoate, butylene glycol dicaprylate/dicaprate, isopropyl myristate, polyglyceryl-2 triisostearate, glyceryl ethyl hexanoate/stearate/adi Fate, triethylhexanoin, hydrogenated polyisobutene, octyldodecanol, caprylic/capric triglyceride, ethylhexyl palmitate, isostearyl isostearate, diisopropyldimerdilinoleate, It may be one or more selected from the group consisting of propylene glycol dibenzoate, isopropyl palmitate, and isohexadecane, preferably using butylene glycol dicaprylate/dicaprate (hereinafter BGC). do. The hydrocarbon-based oil is used in an amount of 8 to 13% by weight, preferably 10% by weight.

In the present invention, when the hydrocarbon-based oil is contained in less than 8% by weight, it is difficult to completely dissolve raspberry ketone, and when it is included in excess of 13% by weight, it is difficult to secure long-term stability due to excessive oil.

The cosmetic composition of the present invention may include a preservative. Preservatives may include one or more selected from the group consisting of 1,2-hexanediol, paraben, phenoxyethanol, clofenesin, ethylhexylglycerin, caprylyl glycol, etc., and the preservatives are cosmetic products of the present invention. It is used in an amount of 1 to 3% by weight based on 100% by weight of the composition, this amount is a conventional amount to obtain a preservative effect in the cosmetic composition. Preferably, the cosmetic composition of the present invention contains 2% by weight of 1,2-hexanediol.

The cosmetic composition of the present invention may include other conditioning raw materials. Other conditioning raw materials may include one or more selected from the group consisting of dipropylene glycol, dipotassium glyceride, and tocopheryl acetate, and may include raw materials not limited thereto according to users. . This conditioning material is used in an amount of 4 to 6% by weight.

Other conditioning raw materials are generally included in 4 to 6% by weight, but are not limited thereto, and may include conditioning raw materials outside this content depending on the user.

The cosmetic composition of the present invention includes particles of a phospholipid nanostructure having an average diameter size of 100 nm or less to facilitate absorption into the skin.

The present invention also provides a skin care composition comprising the cosmetic composition for improving wrinkles of the present invention. Preferably, the skin care composition of the present invention includes the cosmetic composition for improving wrinkles in an amount of 1 to 20% by weight.

In addition, the present invention is a method for preparing the cosmetic composition for improving wrinkles, dissolving glutathione and a neutralizing agent in purified water to form a first mixture, glycerin, a preservative in the first mixture, and 97 to 99 weight of the whole conditioning raw material Forming a second mixture by dissolving% of conditioning material, mixing a hydrocarbon-based oil, saturated lecithin, raspberry ketone, and the remaining conditioning material to form a third mixture, 80°C for the second mixture and the third mixture Warming up to, stirring the second mixture by operating the agitator at 1,000 rpm, and finely introducing the third mixture to form an emulsion containing the nanostructure, which is the fourth mixture, and the fourth mixture for 5 minutes Stirring, cooling the mixture to a temperature of 40° C. while mixing the fourth mixture, and passing the fourth mixture three times under 1,000 bar conditions using a Micronox MN250T to obtain a cosmetic composition containing a phospholipid nanostructure of less than 100 nm. Provides a method comprising steps.

Hereinafter, the composition of the present invention will be specifically described by examples. However, the examples are only illustrative to help understanding of the present invention, and the scope of the present invention is not limited thereby.

Example 1: Preparation of cosmetic composition for wrinkle improvement with phospholipid nanostructures applied

A cosmetic composition for improving wrinkles to which a phospholipid nanostructure was applied was prepared using the ingredients listed in Table 1 below.

First, after dissolving glutathione and a neutralizing agent in purified water in an azimuth mixer to form a first mixture, glycerin, 1,2-hexanediol as a preservative, and dipropylene glycol and dipotassium glycol as a conditioning material are formed in the first mixture. The second mixture was formed by dissolving the jet. In a separate mixer, a third mixture was formed by mixing BGC as a hydrocarbon-based oil, saturated lecithin, raspberry ketone, and tocopheryl acetate as an additional conditioning material. The second mixture and the third mixture were heated to 80°C. While stirring by operating the agitator at 1,000 rpm, a third mixture was finely introduced into the second mixture to form a fourth mixture. The fourth mixture was stirred for an additional 5 minutes, and the fourth mixture was cooled while mixing to 40°C. Subsequently, the fourth mixture was passed three times under 1,000 bar conditions using a Micronox MN250T to prepare a cosmetic composition for improving wrinkles.

ingredient Content (g) Purified water To 1000 Glutathione 5 Arginine 2.5 glycerin 500 1,2-hexanediol 20 Dipropylene glycol 50 Dipotassium glyceride One BGC 100 Saturated lecithin 60 Raspberry Ketone 2.5 Tocopheryl Acetate One

Comparative Example 1: Preparation of a cosmetic composition for improving general wrinkles

After heating the water phase and the oil phase to 80° C. with the composition of Table 1, the homomixer is operated to emulsify for 5 minutes, and then cooled and defoamed to obtain a cosmetic composition.

Example 2: Preparation of an essence comprising a cosmetic composition for wrinkle improvement with phospholipid nanostructures applied

Essence containing the cosmetic composition of the present invention with the composition of Table 2 was prepared.

ingredient Content (g) Purified water To 1000 glycerin 50 Panthenol 50 Betaine 50 Madecassoside 2 Dipotassium glyceride 2 Adenosine 0.4 Niacinamide 50 Disodium ID 0.5 Dipropylene glycol 50 1,2-hexanediol 20 PG-60 Hydrogenated Castor Oil 5 times the equivalent of spices Spices Proper Simugel EG 5 Saccharide isomerate 5 Sodium hyaluronate 1% 5 Biosaccharide gum 1.5% 5 Palmitoylpentapeptide-5 0.1% 5 NSG 5 Retinol One Cosmetic composition of Example 1 100

Comparative Example 2: Preparation of a cosmetic composition for the preparation of a cosmetic composition for improving general wrinkles

In the composition of Table 2, an essence containing the cosmetic composition for improving general wrinkles of Comparative Example 1 was prepared instead of the cosmetic composition of Example 1.

Example 3: Preparation of a lotion comprising a cosmetic composition for wrinkle improvement with phospholipid nanostructures applied

A lotion comprising the cosmetic composition of the present invention was prepared with the composition of Table 3 below.

ingredient Content (g) Purified water To 1000 glycerin 50 Dipropylene glycol 50 Panthenol 50 Betaine 50 Madecassoside 2 Dipotassium glyceride 2 Adenosine 0.4 Niacinamide 50 Disodium ID 0.5 Cetearyl alcohol 5 Polyglyceryl-3 methyl glucose distearate 10 Glyceryl stearate/page-100 stearate 15 Polysorbate 60 10 Saturated lecithin 40 Shea butter 20 Macadamia seed oil 30 Squalane 30 Jojoba seed oil 30 Tocopheryl Acetate One Simugel EG 5 1,2-hexanediol 20 Saccharide isomerate 5 Sodium hyaluronate 1% 5 NSG 5 Retinol One Cosmetic composition of Example 1 100 Spices Proper

Example 4: Preparation of a cream comprising a cosmetic composition for wrinkle improvement with phospholipid nanostructures applied

A cream comprising the cosmetic composition of the present invention was prepared with the composition of Table 4 below.

ingredient Content (g) Purified water To 1000 glycerin 50 Dipropylene glycol 50 Panthenol 50 Betaine 50 Madecassoside 2 Dipotassium glyceride 2 Adenosine 0.4 Niacinamide 50 Disodium ID 0.5 Cetearyl alcohol 40 Polyglyceryl-3 methyl glucose distearate 20 Glyceryl stearate/page-100 stearate 20 Polysorbate 60 10 Sorbitan stearate 10 Saturated lecithin 40 Beads wax 20 Shea butter 30 Macadamia seed oil 30 Squalane 30 Octyldodecyl myristate 230 Triethylhexanoin 10 Octyldodecanol 10 Jojoba ester 30 Tocopheryl Acetate One Simugel EG 5 1,2-hexanediol 20 Saccharide isomerate 5 Sodium hyaluronate 1% 5 Palmitoylpentapeptide-5 0.1% 5 NSG 5 Retinol One Cosmetic composition of Example 1 100 Spices Proper

Experimental Example 1: Particle photography

The composition prepared in Example 1 was photographed. Since the size of the phospholipid nanostructure 100 nm is shorter than the wavelength of visible light 400 nm, it cannot be measured with an optical microscope, and was photographed using an electron microscope (JEM-F200) (FIG. 1). It can be seen from FIG. 1 that the phospholipid nanostructure was appropriately formed in a uniform size.

Experimental Example 2: Particle size measurement

The particle size of the composition prepared in Example 1 was measured using Photal ELSZ-1000 (FIG. 2). It was measured by diluting to 10% due to the high viscosity of the composition, and as a result of the measurement, it was found that the average diameter size was 45.4 nm.

Experimental Example 3: Zeta potential measurement

The zeta potential of the composition prepared in Example 1 was measured using Photal ELSZ-1000 (FIG. 3). It was measured by diluting to 10% due to the high viscosity of the composition. As a result of the measurement, it was found that the potential of the particles was stable at -352.06 mV.

Experimental Example 4: Measurement of wrinkle improvement effect

After 20 men and women in their 50s and 60s with severe wrinkles were divided into 2 groups of 10 each, one group applied the essence of Example 2 3 times a day, and the other group applied the essence of Comparative Example 2 1 day. It was applied three times. After 2 weeks, 4 weeks, 6 weeks, and 8 weeks after the start of application, the degree of wrinkle improvement was visually checked by individuals and scored with 1 point that it was not improved at all and 5 points that it was very improved. It is shown in Table 5. Even when the comparative example 2 including the general emulsion was applied for a long time, wrinkles were improved to some extent, but it was found that better results were obtained when the example 2 was applied for a long time.

Wrinkle improvement W+2 W+4 W+6 W+8 Example 2 2.2 2.8 3.4 3.9 Comparative Example 2 2 2.5 3 3.5

Claims (12)

Raspberry ketone 0.1 to 0.5 wt%, saturated lecithin 5 to 10 wt%, glutathione 0.1 to 1 wt%, glycerin 40 to 60 wt%, neutralizing agent 0.2 to 0.3 wt%, hydrocarbon-based oil based on 100 wt% of the total composition 8 to 12% by weight, 1 to 3% by weight of preservatives and 4 to 6% by weight of conditioning material and the balance of water, and raspberry ketone is liposomed by saturated lecithin to form a phospholipid nanostructure,
Wrinkle improvement cosmetic composition, characterized in that the average diameter of the phospholipid nanostructures is less than 100 nm.
The method according to claim 1, wherein the hydrocarbon-based oil is cetyl ethyl hexanoate, butylene glycol dicaprylate / dicaprate, isopropyl myristate, polyglyceryl-2 triisostearate, glyceryl ethyl hexanoate /Stearate/adipate, triethylhexanoin, hydrogenated polyisobutene, octyldodecanol, caprylic/capric triglyceride, ethylhexyl palmitate, isostearyl isostearate, diisopropyldimer A cosmetic composition for improving wrinkles, which is at least one hydrocarbon-based oil selected from the group consisting of dilinoleate, propylene glycol dibenzoate, isopropyl palmitate, isohexadecane and mixtures thereof.
The cosmetic composition for improving wrinkles according to claim 2, wherein the hydrocarbon-based oil is butylene glycol dicaprylate/dicaprate.
The method according to claim 1, characterized in that the neutralizing agent is at least one neutralizing agent selected from the group consisting of arginine, sodium citrate, sodium hydroxide, potassium hydroxide, triethanolamine, tromethamine and mixtures thereof. Cosmetic composition for wrinkle improvement.
The cosmetic composition for improving wrinkles according to claim 4, wherein the neutralizing agent is arginine.
The method according to claim 1, wherein the preservative is one or more preservatives selected from the group consisting of 1,2-hexanediol, parabens, phenoxyethanol, clofenesin, ethylhexylglycerin, caprylyl glycol, and mixtures thereof. Cosmetic composition for wrinkle improvement.
The method of claim 6, wherein the preservative is a cosmetic composition for improving wrinkles, characterized in that 1,2-hexanediol.
The method according to claim 1, wherein the conditioning raw material is dipropylene glycol, dipotassium glyceride, tocopheryl acetate, and a cosmetic composition for improving wrinkles, characterized in that at least one conditioning raw material selected from the group consisting of mixtures thereof.
delete Skin care composition comprising the cosmetic composition for improving wrinkles according to claim 1.
The method according to claim 10, Skin care composition comprising the cosmetic composition for improving wrinkles according to claim 1 in an amount of 1 to 20% by weight.
As a method for producing a cosmetic composition for improving wrinkles of claim 1,
Dissolving glutathione and a neutralizing agent in purified water to form a first mixture,
Dissolving 97 to 99% by weight of the conditioning material in the first mixture of glycerin, preservatives, and the entire conditioning material to form a second mixture,
Forming a third mixture by mixing hydrocarbon-based oil, saturated lecithin, raspberry ketone, and the remaining conditioning raw materials,
Heating the second mixture and the third mixture to 80° C.,
The second mixture is stirred by operating the agitator at 1,000 rpm, while finely introducing the third mixture to form an emulsion containing the nanostructure, which is the fourth mixture,
Stirring the fourth mixture for 5 minutes,
Cooling to 40° C. while mixing the fourth mixture, and
A method comprising passing a fourth mixture three times under 1,000 bar conditions using a Micronox MN250T to obtain a cosmetic composition containing a phospholipid nanostructure having an average diameter size of less than 100 nm.

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