KR102477246B1 - Composition for stabilizing insoluble ingredient and cosmetic composition containing the same - Google Patents

Abstract

The present invention relates to a composition for stabilizing poorly soluble components containing hydrogenated lecithin and an anionic surfactant as active ingredients. In addition, the present invention is a method for stabilizing a poorly soluble component in a cosmetic formulation using the composition for stabilizing a poorly soluble component, a cosmetic composition comprising the composition for stabilizing a poorly soluble component and a poorly soluble component, and a method for preparing the cosmetic composition It is about.
The composition for stabilizing poorly soluble active ingredients of the present invention prevents separation and precipitation by stabilizing poorly soluble ingredients in cosmetic formulations. Therefore, by overcoming the limitations of poorly soluble ingredients that were difficult to apply to cosmetic compositions due to precipitation problems over time, cosmetic compositions containing poorly soluble ingredients having various types of formulations are provided.

Description

Composition for stabilizing insoluble ingredients and cosmetic composition containing the same {Composition for stabilizing insoluble ingredient and cosmetic composition containing the same}

The present invention relates to a composition for stabilizing poorly soluble components containing hydrogenated lecithin and an anionic surfactant as active ingredients.

The present invention relates to a method for stabilizing a poorly soluble component in a cosmetic formulation using the composition for stabilizing a poorly soluble component, a cosmetic composition comprising the composition for stabilizing a poorly soluble component and a poorly soluble component, and a method for preparing the cosmetic composition. will be.

In the development of cosmetics, there are many poorly soluble substances that do not dissolve in either water or oil among ingredients that provide skin improvement effects such as whitening or wrinkle improvement. Various methods of stabilizing these poorly soluble substances have been attempted to impart skin improvement effects by including them in cosmetics.

As an example, an emulsifier having an excess polyol and sealing power without water was developed to develop a cream formulation to stabilize components that are easily precipitated from water to impart spreadability and sealing power to cosmetic products (Korean Patent Publication 10- 2016-0031850). However, other problems, such as instability over time and a stuffy feeling due to the use of an excessive amount of polyol, have not yet been solved.

In addition to such formulation technology, studies have been conducted to stabilize poorly soluble drugs in the form of polymeric micelles or nanoparticles using amphoteric block copolymers and to develop pharmaceutically usable compositions (Korean Patent Publication 10-2010- 0084399). However, when it is manufactured as a cosmetic product, aggregation between block copolymers occurs and the problem of precipitation over time still exists, so there is still a limit to stabilizing poorly soluble substances and applying them to products.

Under the above background, the present inventors have studied to develop a cosmetic composition in which precipitation does not occur while sufficiently exhibiting the functional effect of poorly soluble components, and as a result, using a combination of hydrogenated lecithin and an anionic surfactant, poorly soluble substances It was confirmed that it can be sufficiently stabilized in a cosmetic formulation and the present invention was completed.

An object of the present invention is to provide a composition for stabilizing poorly soluble components containing hydrogenated lecithin and an anionic surfactant as active ingredients.

Another object of the present invention is to provide a composition for stabilizing the poorly soluble component and a cosmetic composition comprising the poorly soluble component.

Another object of the present invention is to provide a method for stabilizing a poorly soluble component in a cosmetic formulation, comprising: mixing hydrogenated lecithin and an anionic surfactant.

Another object of the present invention is to provide a method for producing a cosmetic composition in which poorly soluble components are dissolved.

One aspect of the present invention provides a composition for stabilizing poorly soluble components comprising hydrogenated lecithin and an anionic surfactant as active ingredients.

In general, it is difficult to stably contain a poorly soluble component having low solubility in both an oil phase and an aqueous phase with only a stabilizer used in cosmetics. Poorly soluble components exist in an unstable state in cosmetic formulations, and the instability increases over time, causing recrystallization to proceed and precipitation to occur.

In order to solve this problem, the present invention has developed a composition for stably including poorly soluble ingredients in a cosmetic formulation, and by mixing an anionic surfactant with hydrogenated lecithin, a stable structure, that is, micelles, without a high-pressure emulsification process A low-viscosity, transparent formulation that forms micelles was prepared. In addition, it is characterized in that separation and precipitation of poorly soluble components are prevented by stabilizing poorly soluble components in the stable structure.

In the present invention, "hydrogenated lecithin" means a hydrogenated lecithin product, and serves to increase the stability of the structure. The lecithin is a representative naturally-derived surfactant, meaning that it encompasses a group of yellowish fatty substances occurring in animal and plant tissues composed of phosphoric acid, choline, fatty acids, glycerol, glycolipids, and triglyceride phospholipids. In the present invention, lecithin is egg yolk, It includes both naturally derived lecithin and synthetic lecithin extracted from animals and plants such as soybean and corn, and microorganisms such as Escherichia coli. Specifically, examples of lecithin include natural phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, rhizophosphatidylcholine, sphingomyelin, egg yolk "lecithin, soybean" lecithin, or dilauroylphosphatidylcholine, dimyristoylphosphatidylcholine, Synthesis of palmitoylphosphatidylcholine, distearoylphosphatidylcholine, dioleoylphosphatidylcholine, palmitoylphosphatidylcholine, oleoylphosphatidylcholine, etc. may be mentioned, but is not limited thereto. In general, naturally-derived lecithin may have a phosphatidylcholine content of 23 to 95% by weight and a phosphatidylethanolamine content of 20% by weight or less, but is not limited thereto.

The hydrogenated lecithin of the present invention may contain hydrogenated phosphatidylcholine of 10 to 99% by weight, specifically 50 to 90% by weight, but is not limited thereto.

When hydrogenated lecithin is used alone as a stabilizer in a cosmetic formulation, a structure in the form of a liposome is formed. However, since such a structure has an open shape and has high flexibility, it is difficult to maintain the shape such that the structure is easily deformed or broken. Accordingly, it is difficult to secure the stability of poorly soluble substances, and the change in stability over time is also large. In the present invention, this problem is solved by using an anionic surfactant together with hydrogenated lecithin.

The hydrogenated lecithin may be included in 0.1 to 20% by weight, specifically 0.3 to 10% by weight, 0.5 to 5% by weight, or 1 to 5% by weight based on the total weight of the composition for stabilizing the poorly soluble component. , but not limited thereto.

If the content of hydrogenated lecithin is less than 0.1% by weight, poorly soluble components cannot be sufficiently dissolved, resulting in precipitation and precipitation of poorly soluble components, and if it exceeds 20% by weight, the particle size of the structure increases, resulting in unstable formulation. Problems can arise.

In the present invention, "anionic surfactant" means a surfactant containing only anionic functional group as an ionic or ionizable group. The anionic surfactant forms a low-viscosity transparent formulation when mixed with hydrogenated lecithin, and helps to form a stable structure with lecithin by adjusting the packing parameter of hydrogenated lecithin. Separation and precipitation of poorly soluble components are prevented by stabilizing poorly soluble components through the structure prepared as described above.

In the present invention, conventional anionic surfactants known in the art may be used without limitation, and specifically, the anionic functional group included in the anionic surfactant is specifically PO ₄ ^3- , -CO ₂ ^- , -SO ₃ ^- , -OSO ₃ ^- , -HPO ₃ ^- , -PO ₃ ^2- , -HPO ₂ ^- , -PO ₂ ^2- , -PO ^- , or a combination thereof, specifically phosphate (PO ₄ ^3- ); or metal salts of carboxylic acids such as sodium salts, potassium salts, ammonium salts, magnesium salts, specifically sodium salts of carboxylic acids; Or it may be a combination thereof, but is not limited thereto. In addition, as long as it can be mixed with hydrogenated lecithin to form a stable structure, it can be used without being limited to its type.

Specifically, anionic surfactants include amino acid-derived surfactants, alkyl　phosphates, alkylsulfates, alkyl ether sulfates, alkyl 　monoglyceryl ether sulfates, alkyl sulfonates, alkylaryl sulfonates, alkyl sulfosuccinates, alkyl ether sulfosuccinates. nates, “alkyl” sulfosuccinamates, “alkyl” amidosulfosuccinates, “alkyl” carboxylates, “alkyl” amidoether carboxylates, “alkyl” succinates, fatty acyl sarcosinates, fatty acyl amino acids, fatty acyl taurates, fatty “alkyl” sulfoacetates, or It may be a combination thereof, and may specifically be an alkyl phosphate, but is not limited thereto.

The amino acid-derived surfactant is derived from a carboxylate salt of an amino acid, and may specifically include sodium dilauramidoglutamide lysine having a glutamic acid-lysine-glutamic acid structure derived from lysine.

The alkyl phosphate includes cetyl phosphate, PPG-10 cetyl phosphate, PPG-5-ceteth-10 phosphate, oleth-3 phosphate, oleth-10 phosphate, ceteth-10 phosphate, ceteth-10 phosphate, dicetyl phosphate, stearyl phosphate ) or a mixture thereof, and more specifically, cetyl phosphate, but is not limited thereto.

Specifically, for the purpose of the present invention, the anionic surfactant may be cetyl phosphate, sodium dilauramidoglutamide lysine or a mixture thereof, and by mixing the above material with hydrogenated lecithin, the poorly soluble component may be removed from the cosmetic composition. A stabilizing composition can be prepared in

In the present invention, the anionic surfactant may be included in 0.001 to 4% by weight based on the total weight of the composition for stabilizing the poorly soluble component, specifically 0.01 to 2% by weight, 0.2 to 1.0% by weight, or 0.1 to 0.5% by weight. may be included, but is not limited thereto.

If the content of the anionic surfactant is less than 0.001% by weight, the packing parameter of the hydrogenated lecithin cannot be adjusted, so that a transparent formulation may not be prepared, and if the content exceeds 4% by weight, the problem of precipitation of the anionic surfactant may occur. .

The stability of the composition may vary depending on the mixing ratio of the hydrogenated lecithin and the anionic surfactant included in the composition for stabilizing poorly soluble components of the present invention. In addition, the mixing ratio with hydrogenated lecithin that maximizes the stability of the composition may vary depending on the type of anionic surfactant.

Specifically, when the anionic surfactant is cetyl phosphate, the mixing ratio of the hydrogenated lecithin and the anionic surfactant may be 1:0.005 to 40, specifically 1:0.02 to 1, 1:0.05 to 1:0.05 by weight. 1, 1: 0.2 to 1, 1: 0.2 to 0.5, 1: 0.2 to 0.3, 1: 0.2 to 0.25, but is not limited thereto.

In addition, when the anionic surfactant is sodium dilauramidoglutamide lysine, the mixing ratio of the hydrogenated lecithin and the anionic surfactant may be 1:0.005 to 40, specifically 1:0.1 to 2 by weight. , 1: 0.3 to 2, 1: 0.6 to 1: 2 or less, 1: 0.6 to 1: 1 or less, 1: 0.6 to 1: 0.8 or less, 1: 0.8 to 1: 1, but is not limited thereto.

The composition for stabilizing poorly soluble components of the present invention may further include oil. When an oil is additionally included in the composition for stabilizing a poorly soluble component of the present invention, the stabilizing effect of the poorly soluble component may be higher, and the oil may be used without limitation of oil commonly used in the art.

Specifically, the oil may use hydrocarbon-based oil, ester-based oil, silicone oil, or a mixture thereof, but is not limited thereto. Hydrogenated polyisobutene, hydrogenated polydecene, paraffin or a combination thereof as hydrocarbon-based oils, dipentaerythritihexa C _5-9 acid ester, diisostearyl maleate, C ₁₂ as ester-based oils _-15 Alkyl Octanoate, Myristyl Lactate, Cetyl Ethyl Hexanoate, Cetyl Octanoate, Isopropyl Myristate, Octyldodecyl Myristate, Hexyl Laurate, Pentaerythyl Tetraethylhexanoate, Diglyceride lyltriisostearate or a combination thereof, dimethicone, cyclomethicone, polydimethylsiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane as silicone oil, Tetradecamethylhexasiloxane, octamethyltrisiloxane, or a combination thereof may be used, and hydrogenated polyisobutene may be used for the purpose of the present invention, but is not limited thereto.

In one embodiment of the present invention, when a composition for stabilizing poorly soluble ingredients is prepared by including hydrogenated polyisobutene together with hydrogenated lecithin and cetyl phosphate, and the composition is included in a cosmetic formulation together with poorly soluble ingredients, after preparation 4 Even after a week, the properties of the cosmetic formulation were maintained and precipitation did not occur, confirming that poorly soluble components were stably dissolved for a long period of time (Table 7).

Another aspect of the present invention provides a composition for stabilizing the poorly soluble component and a cosmetic composition comprising the poorly soluble component.

The "composition for stabilizing poorly soluble components" is as described above.

In the present invention, "poorly soluble component" refers to a substance that is not sufficiently soluble in water or oil and exists unstable, and is used in cosmetic compositions to provide useful effects to the skin such as wrinkle improvement, skin whitening, and skin moisturizing. can

Specifically, the poorly soluble components included in the composition of the present invention include cedrol, formononetin, magonolol, honokiol, phloretin, ceramide, Quantitative extract of Centella asiatica, fisetin, daidzerin, genistein, glycitein, adenosine, polydatin, retinol, gamma- Aminobutyric acid, arbutin, macelignan, acetyl phytosphingosine, hydroquinone, hydroxyanisole, ascorbic acid acid), kojic acid (kojic acid), and retinoids (retinoids) may be at least one selected from the group consisting of, may specifically be cedrol, but is not limited thereto. Any component commonly used in the art to provide beneficial effects to the skin is applicable to the present invention without being limited to the type.

In one embodiment of the present invention, it was confirmed that the precipitation of cedrol can be prevented by including cedrol in a cosmetic formulation together with a mixture of hydrogenated lecithin and cetyl phosphate. As such, the cosmetic composition of the present invention has the effect of stably including poorly soluble components to prevent their separation and precipitation, and specifically has the advantage that separation and precipitation do not occur under temperature conditions of -20 to 60 ° C. That is, the cosmetic composition of the present invention can maintain a stable form for a long period of time even at room temperature, low temperature, and high temperature conditions.

The composition for stabilizing poorly soluble components of the present invention can stabilize poorly soluble components in various formulations from high-viscosity formulations to low-viscosity formulations. The cosmetic composition containing the poorly soluble component of the present invention can be formulated into any formulation commonly prepared in the art, and has various applications such as high-viscosity cream, low-viscosity skin, lotion, essence, mist, and spray formulation. It is possible.

For example, toner, lotion, essence, cream or eye cream, solution, external ointment, foam, nutrient lotion, softening lotion, pack, softening water, emulsion, makeup base, soap, liquid cleanser, bath additive, sunscreen cream, sun oil, Suspensions, emulsions, pastes, gels, powders, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations, patches and sprays may be prepared in formulations selected from the group consisting of, but are not limited thereto.

In addition, the cosmetic composition of the present invention may further include one or more cosmetically acceptable carriers formulated in general skin cosmetics, and as typical ingredients, for example, oil, water, surfactants, moisturizers, lower alcohols, A thickener, a chelating agent, a colorant, a preservative, a flavoring agent, and the like may be suitably blended, but are not limited thereto. Cosmetically acceptable carriers included in the cosmetic composition of the present invention vary depending on the formulation.

Another aspect of the present invention provides a method for stabilizing a poorly soluble component in a cosmetic formulation, comprising: mixing hydrogenated lecithin and an anionic surfactant.

"Hydrogenated lecithin", "anionic surfactant", and "poorly soluble component" are as described above.

Specifically, it is possible to stabilize the poorly soluble component in the cosmetic composition by mixing a mixture of hydrogenated lecithin and anionic surfactant together with the poorly soluble component.

The hydrogenated lecithin and the anionic surfactant may be added sequentially, in reverse order or simultaneously and mixed, and the poorly soluble component may be added after mixing both the hydrogenated lecithin and the anionic surfactant, or the poorly soluble component prior to mixing may be first mixed with hydrogenated lecithin or an anionic surfactant and then added and mixed with the remaining ingredients. Finally, if the poorly soluble ingredients can be stabilized by preparing a cosmetic composition containing all of the hydrogenated lecithin, anionic surfactant, and poorly soluble ingredients, the time and order of adding and mixing them is not limited.

The anionic surfactant may be cetyl phosphate, sodium dilauramidoglutamide lysine or a mixture thereof.

Another aspect of the present invention is (S1) adding a poorly soluble component, hydrogenated lecithin and an anionic surfactant to a solvent; And (S2) adding the result of step (S1) to the aqueous phase; provides a method for producing a cosmetic composition in which poorly soluble components are dissolved.

The anionic surfactant may be cetyl phosphate, sodium dilauramidoglutamide lysine or a mixture thereof.

"Hydrogenated lecithin", "anionic surfactant", and "poorly soluble component" are as described above.

The cosmetic composition prepared by the manufacturing method of the present invention contains poorly soluble components stably, and can be stably maintained without separation and precipitation of poorly soluble components for a long time under various formulations and temperature conditions.

The composition for stabilizing poorly soluble active ingredients of the present invention prevents separation and precipitation by stabilizing poorly soluble ingredients in cosmetic formulations. Therefore, by overcoming the limitations of poorly soluble ingredients that were difficult to apply to cosmetic compositions due to precipitation problems over time, cosmetic compositions containing poorly soluble ingredients having various types of formulations are provided.

1 is a photograph showing the turbidity of a formulation according to the weight ratio of hydrogenated lecithin and cetyl phosphate.
2 is a photograph of the stability over time of Example 10 and Comparative Example 1 observed under a microscope.

Hereinafter, examples and the like will be described in detail to aid understanding of the present invention. However, the embodiments according to the present invention can be modified in many different forms, and the scope of the present invention should not be construed as being limited to the following examples. Embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

Experimental Example 1. Confirmation of formulation properties and turbidity of the composition for stabilizing poorly soluble components

1-1. Preparation of a composition for stabilizing poorly soluble components

As shown in Table 1 below, cosmetic compositions containing various types and combinations of ingredients were prepared.

First, the oil phase and the aqueous phase were dissolved by heating to 65°C, respectively. The oil phase was gradually added while stirring the water phase with a homomixer at 2000 rpm. After the oil phase was completely added, it was prepared by stirring for 3 minutes with a homomixer at 2000 to 2500 rpm and then cooling to 28 ° C. The composition for stabilizing the poorly soluble component was prepared as a skin formulation.

division raw material name Example 1 Example 2 Example 3 Example 4 Example 5 Paid ethanol 2 2 2 2 2 Dipropylene Glycol One One One One One Hydrogenated Lecithin One One One One One cetyl phosphate 0.05 0.1 0.15 0.2 0.25 incense 0.1 0.1 0.1 0.1 0.1 Awards Purified water balance balance balance balance balance arginine 0.025 0.05 0.08 0.1 0.13 glycerin 8 8 8 8 8 propanediol 5 5 5 5 5 1.2-hexanediol 1.5 1.5 1.5 1.5. 1.5 panthenol 1.5 1.5 1.5 1.5 1.5

division raw material name Example 6 Example 7 Example 8 Paid ethanol 2 2 2 Dipropylene Glycol One One One Hydrogenated Lecithin One One One Sodium dilauramidoglutamide lysine 0.3 0.6 0.8 incense 0.1 0.1 0.1 Awards Purified water Up to 100 Up to 100 Up to 100 glycerin 8 8 8 propanediol 5 5 5 1,2-hexanediol 1.5 1.5 1.5 panthenol 1.5 1.5 1.5

1-2. Measurement of formulation properties and turbidity immediately after preparation

In order to confirm that the formulation of the composition for stabilizing a poorly soluble component prepared in Preparation Example 1 was formed transparently, its properties were observed immediately after preparing the composition in Preparation Example 1. To compare the properties of the formulation, the degree of turbidity was checked with the naked eye and the turbidity was measured using a turbidimeter. Turbidity was measured using HACH's TL2350 model, which measures turbidity using a light scattering method, and was expressed as the average value of a total of 5 measurements. Each example was measured at 25°C. The results are shown in Table 3.

Example 1 Example 2 Example 3 Example 4 Example 5 Example
6 Example
7 Example
8 appearance suspension semi-suspension translucent Transparency Transparency suspension Transparency Transparency Turbidity value (NTU) 1052 305 52.77 35.60 12.10 1120 38 16.20

As can be seen from Table 3 and FIG. 1, it was confirmed that the composition became more transparent as the content of cetyl phosphate or sodium dilauramidoglutamide lysine increased relative to the content of hydrogenated lecithin. Both the results of observation with the naked eye and the measurement of turbidity were like this.

1-3. Comparison of formulation properties and turbidity over time

In order to find conditions for hydrogenated lecithin and anionic surfactants suitable for stabilizing poorly soluble components, formulation stability over time of the cosmetic compositions of Examples 1 to 8 was evaluated. A formulation property comparison experiment was performed in the same manner as in Experimental Example 1, and the results are shown in Tables 4 and 5.

Example 1 Example 2 Example 3 Example 4 Example 5 immediately after manufacturing
Turbidity (NTU) suspension
1052 semi-suspension
305 translucent
52.77 Transparency
35.60 Transparency
12.10 The next day (room temperature)
Turbidity (NTU), room temperature
Turbidity (NTU), -20°C suspension
1232
1488 suspension
380
450 translucent
60.22
112.20 Transparency
36.12
45.21 Transparency
12.68
16.74 Turbidity (NTU) 1 week after manufacturing (room temperature), room temperature
Turbidity (NTU), -20°C suspension
1300
1670 suspension
412
705 suspension
53.24
705 Transparency
35.16
44.04 Transparency
15.10
20.48 4 weeks after manufacturing (room temperature) turbidity (NTU), room temperature
Turbidity (NTU), -20°C suspension
1392
1710 suspension
410
762 suspension
52.76
762 Transparency
40.10
46.10 Transparency
16.88
24.04

Example 6 Example 7 Example 8 Turbidity after manufacturing (NTU) suspension
1120 Transparency
38 Transparency
16.20 Next day (room temperature) turbidity (NTU), room temperature
Turbidity (NTU), -20°C suspension
1200
1420 translucent
50.2
52 Transparency
16.22
21.20 Turbidity (NTU) 1 week after manufacturing (room temperature), room temperature
Turbidity (NTU), -20°C suspension
1250
1580 translucent
54
60.2 Transparency
18.42
25.20 4 weeks after manufacturing (room temperature) turbidity (NTU), room temperature
Tick degree (NTU), -20℃ suspension
1340
1740 translucent
54.6
67 Transparency
18.80
27.32

As shown in Table 4, as the content of cetyl phosphate relative to the content of hydrogenated lecithin increased, the properties did not change and remained transparent under room temperature conditions. On the other hand, in the case of Examples 1 to 3 having a relatively low content of cetyl phosphate, it was confirmed that turbidity occurred due to a change in properties over time.

On the other hand, comparing long-term stability, in Examples 1 to 3 in which 0.15% by weight or less of cetyl phosphate was applied when hydrogenated lecithin was 1% by weight, the properties changed within 1 week of manufacture, resulting in turbidity at -20 ° C. Suspension also occurred in stability.

On the other hand, in Examples 4 and 5 in which 0.2% by weight or more of cetyl phosphate was applied, the properties were maintained even after 4 weeks of preparation. This suggests that the weight ratio of hydrogenated lecithin to cetyl phosphate is important, and that the stability of the composition for stabilizing poorly soluble components is maintained only when the weight of cetyl phosphate is 0.2 parts by weight or more relative to 1 part by weight of hydrogenated lecithin.

In addition, as shown in Table 5, as the content of sodium dilauramidoglutamide lysine relative to the content of hydrogenated lecithin increased, the properties did not change and the transparent state could be maintained under room temperature conditions. On the other hand, in the case of Examples 6 to 7 having a relatively low content of sodium dilauramidoglutamide lysine, it was confirmed that turbidity occurred due to a change in properties over time.

Comparing long-term stability, in Examples 6 to 7 in which sodium dilauramidoglutamide lysine was applied at 0.6% by weight or less when hydrogenated lecithin was 1% by weight, the properties changed from the next day to generate turbidity, and -20 ° C. Suspension also occurred in stability.

On the other hand, in Example 8, in which sodium dilauramidoglutamide lysine was applied in an amount of more than 0.6% by weight, the properties were maintained even 4 weeks after preparation. This is because the weight ratio of hydrogenated lecithin and sodium dilauramidoglutamide lysine is important, and when the amount of sodium dilauramidoglutamide lysine exceeds 0.6 parts by weight relative to 1 part by weight of hydrogenated lecithin, the composition for stabilizing poorly soluble components This suggests that stability is better.

Experimental Example 2. Formulation properties and stability comparison of cosmetic compositions containing poorly soluble ingredients

2-1. Preparation of a cosmetic composition containing poorly soluble ingredients

From Experimental Example 1, it was confirmed that the stability of the composition for stabilizing the poorly soluble component of Example 4 in which the mixing ratio of hydrogenated lecithin and anionic surfactant was 1: 0.2 was the best, and furthermore, the poorly soluble component of Example 4 An actual cosmetic composition was prepared by applying a poorly soluble component to the stabilizing composition.

로 가열하여 용해하였다. 수상을 호모믹서 2000rpm으로 교반하면서 유상을 서서히 첨가하였다. 유상을 완전히 첨가한 후 호모믹서 2000~2500rpm으로 3분간 교반한 후 28

까지 냉각하여 제조하였다. 해당 난용성 효능 성분을 포함하는 화장료 조성물은 스킨 제형으로 제조하였다.Specifically, a cosmetic composition was prepared using the ingredients and contents shown in Table 6 below. First of all, 65 awards and paid awards respectively.

It was dissolved by heating. The oil phase was gradually added while stirring the water phase with a homomixer at 2000 rpm. After completely adding the oil phase, stir for 3 minutes with a homomixer at 2000 to 2500 rpm, and then

It was prepared by cooling to The cosmetic composition containing the poorly soluble active ingredient was prepared as a skin formulation.

division raw material name Example 9 Example 10 Example 11 Comparative Example 1 Comparative Example 2 Paid ethanol 2 2 2 2 2 Dipropylene Glycol One One One One One Hydrogenated Polyisobutene - 0.2 0.2 - - cedrol 0.05 0.05 0.1 0.05 0.1 Hydrogenated Lecithin One One One One One cetyl phosphate 0.2 0.2 0.2 - - PEG-40 Hydrogenated Castor Oil - - - 0.3 0.3 incense 0.1 0.1 0.1 0.1 0.1 Awards Purified water balance balance balance balance balance arginine 0.1 0.1 0.1 - - glycerin 8 8 8 8 8 propanediol 5 5 5 5 5 1.2-hexanediol 1.5 1.5 1.5 1.5. 1.5 panthenol 1.5 1.5 1.5 1.5 1.5

2-2. Comparison of Formulation Properties and Stability

Formulation stability of the cosmetic compositions of Examples 9 to 11 and Comparative Examples 1 to 2 was evaluated in order to find conditions suitable for the poorly soluble active ingredient (cedrol). Stability evaluation was evaluated visually and under a microscope by closing and sealing a lid in a transparent plastic container and storing it at room temperature. The results are shown in Table 7 below.

Example 9 Example 10 Example 11 Comparative Example 1 Comparative Example 2 immediately after manufacture Transparency Transparency Transparency Transparency Transparency The next day (room temperature) maintenance of appearance maintenance of appearance maintenance of appearance maintenance of appearance precipitation Manufacturing 1 week (room temperature) maintenance of appearance maintenance of appearance maintenance of appearance precipitation precipitation Manufacturing 4 weeks (room temperature) precipitation maintenance of appearance maintenance of appearance precipitation precipitation

As shown in Table 7, in the case of Examples 9 to 11 using hydrogenated lecithin and cetyl phosphate, precipitation did not occur well at room temperature. On the other hand, in Comparative Example 2 in which the cedrol content was increased when cetyl phosphate was not added, precipitation occurred from the first day of manufacture.

Comparing the long-term stability, in Comparative Example 1 and Comparative Example 2 of the general solubilization formulation without the addition of cetyl phosphate, precipitation occurred within 1 week of preparation. On the other hand, in the case of Example 9 without hydrogenated polyisobutene, precipitation occurred after 4 weeks of preparation. In Examples 10 and 11 to which hydrogenated polyisobutene was applied, precipitation did not occur and properties were maintained even after 4 weeks after manufacture. The stability of the formulations of Example 10 and Comparative Example 1 over time was observed under a polarizing microscope and is shown in FIG. 2 .

Through these results, in the cosmetic composition containing hydrogenated lecithin and cetyl phosphate, the stability of poorly soluble ingredients such as cedrol is increased, and in addition, when oil such as hydrogenated polyisobutene is applied together, long-term stability was found to be more advantageous.

Experimental Example 3. Comparison of Formulation Properties and Stability by Viscosity of Cosmetic Compositions

3-1. Preparation of low-viscosity and high-viscosity transparent cosmetic compositions

Low-viscosity and high-viscosity transparent cosmetic compositions were prepared with the ingredients and contents shown in Table 8 below. The manufacturing method was performed in the same manner as in Experimental Example 2-1.

division raw material name Example 12 Example 13 Example 14 Paid ethanol 2 2 2 Dipropylene Glycol One One One cedrol 0.1 0.1 0.1 Hydrogenated Polyisobutene 0.2 0.2 0.2 Hydrogenated Lecithin One 4 5 cetyl phosphate 0.2 0.8 1.0 incense 0.1 0.1 0.1 Awards purified water 1 balance balance balance arginine 0.28 0.48 0.68 glycerin 8 8 8 propanediol 5 5 5 1.2-hexanediol 1.5 1.5 1.5 panthenol 1.5 1.5 1.5 polymer phase purified water 2 20 20 20 carbomer 0.18 0.18 0.18

3-2. Comparison of Formulation Properties and Stability

In order to confirm the stability of various formulations (low-viscosity and high-viscosity transparent formulations) containing poorly soluble active ingredients, the stability of Examples 12 to 14 was evaluated. Stability evaluation was visually observed by closing and sealing a transparent plastic container and storing it at room temperature and -20 ° C conditions. The results are shown in Table 9 below.

Example 12 Example 13 Example 14 immediately after manufacture Transparent low-viscosity skin phase Transparent Essence Award transparent gel cream The next day (room temperature) -20℃ maintenance of appearance
no precipitation maintenance of appearance
no precipitation maintenance of appearance
no precipitation Manufacturing 1 week (room temperature) -20℃ maintenance of appearance
no precipitation maintenance of appearance
no precipitation maintenance of appearance
no precipitation Manufacturing 4 weeks (room temperature) -20℃ maintenance of appearance
no precipitation maintenance of appearance
no precipitation maintenance of appearance
no precipitation

As shown in Table 9, in all of Examples 12 to 14 of various formulations, it was confirmed that cedrol did not precipitate and remained stable until 4 weeks after preparation. That is, it was found that the cosmetic composition prepared in the present invention can stabilize poorly soluble components in various types of formulations.

From the above description, those skilled in the art to which the present invention pertains will be able to understand that the present invention may be embodied in other specific forms without changing its technical spirit or essential features. In this regard, the embodiments described above should be understood as illustrative in all respects and not limiting. The scope of the present invention should be construed as including all changes or modifications derived from the meaning and scope of the claims to be described later and equivalent concepts rather than the detailed description above are included in the scope of the present invention.

Claims (12)

Contains hydrogenated lecithin and an anionic surfactant as active ingredients,
Poorly soluble components can be stabilized by including sodium dilauramidoglutamide lysine as the anionic surfactant,
The poorly soluble component is cedrol, formononetin, magnolol, honokiol, phloretin, ceramide, Centella asiatica quantitative extract, fisetin (fisetin), daidzerin, genistein, glycitein, adenosine, polydatin, retinol, γ-aminobutyric acid ), arbutin, macelignan, acetyl phytosphingosine, hydroquinone, hydroxyanisole, ascorbic acid, kojic acid And at least one selected from the group consisting of retinoids (retinoids), a composition for stabilizing poorly soluble components. delete The composition for stabilizing poorly soluble components according to claim 1, wherein the mixing ratio of the hydrogenated lecithin and the anionic surfactant is 1:0.005 to 40 by weight. The composition for stabilizing a poorly soluble component according to claim 1, wherein the hydrogenated lecithin is contained in an amount of 0.1 to 20% by weight based on the total weight of the composition for stabilizing a poorly soluble component. According to claim 1, wherein the anionic surfactant is included in 0.001 to 4% by weight based on the total weight of the composition for stabilizing poorly soluble components, the composition for stabilizing poorly soluble components. According to claim 1, wherein the composition is a composition for stabilizing a poorly soluble component that further comprises an oil. A cosmetic composition comprising the composition for stabilizing the poorly soluble component of claim 1 and the poorly soluble component. delete Mixing hydrogenated lecithin and an anionic surfactant;
As the anionic surfactant, including sodium dilauramidoglutamide lysine to stabilize poorly soluble ingredients in cosmetic formulations,
The poorly soluble component is cedrol, formononetin, magnolol, honokiol, phloretin, ceramide, Centella asiatica quantitative extract, fisetin (fisetin), daidzerin, genistein, glycitein, adenosine, polydatin, retinol, γ-aminobutyric acid ), arbutin, macelignan, acetyl phytosphingosine, hydroquinone, hydroxyanisole, ascorbic acid, kojic acid And a method for stabilizing one or more poorly soluble ingredients selected from the group consisting of retinoids in a cosmetic formulation. 10. The method of claim 9, wherein the anionic surfactant is cetyl phosphate, sodium dilauramidoglutamide lysine, or a mixture thereof. (S1) adding a poorly soluble component, hydrogenated lecithin and an anionic surfactant to a solvent; and
(S2) including the step of adding the product of step (S1) to the aqueous phase,
The poorly soluble component is cedrol, formononetin, magnolol, honokiol, phloretin, ceramide, Centella asiatica quantitative extract, fisetin (fisetin), daidzerin, genistein, glycitein, adenosine, polydatin, retinol, γ-aminobutyric acid ), arbutin, macelignan, acetyl phytosphingosine, hydroquinone, hydroxyanisole, ascorbic acid, kojic acid And at least one selected from the group consisting of retinoids,
Method for producing a cosmetic composition in which poorly soluble components are dissolved, including sodium dilauramidoglutamide lysine as the anionic surfactant. delete

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