KR20200131795A - Composition for stabilizing insoluble ingredient and cosmetic composition containing the same - Google Patents

Abstract

The present invention relates to a composition for stabilizing poorly soluble components, comprising hydrogenated lecithin and an anionic surfactant as active ingredients. In addition, the present invention relates to a method for stabilizing poorly soluble components in a cosmetic formulation using the composition for stabilizing the poorly soluble components, to the composition for stabilizing the poorly soluble components, to a cosmetic composition comprising the poorly soluble components, and to a method for producing the cosmetic composition. The composition for stabilizing the poorly soluble components of the present invention stabilizes the poorly soluble components in the cosmetic formulation to prevent separation and precipitation. Accordingly, it provides the cosmetic composition comprising poorly soluble components having various types of formulations by overcoming the limitations of poorly soluble components, difficult to be applied to cosmetic composition due to a precipitation problem with time.

Description

Composition for stabilizing insoluble ingredient and cosmetic composition containing the same}

The present invention relates to a composition for stabilizing poorly soluble components comprising hydrogenated lecithin and an anionic surfactant as active ingredients.

The present invention relates to a method for stabilizing a poorly soluble component in a cosmetic formulation using the poorly soluble component stabilizing composition, a cosmetic composition comprising the poorly soluble component stabilizing composition and a poorly soluble component, and a method for preparing the cosmetic composition will be.

In cosmetic development, among the ingredients that impart skin improvement effects such as whitening and wrinkle improvement to the skin, there are many poorly soluble substances that do not dissolve in either water or oil. Various methods of stabilizing such a poorly soluble substance have been attempted in order to impart skin improvement effects in cosmetics.

As an example, by developing a cream with a formulation that does not contain water and applies an emulsifier having an excessive amount of polyol and sealing power, it was attempted to stabilize the components easily precipitated from water to give the cosmetic product application and sealing power (Korean Patent Publication 10- 2016-0031850). However, other problems such as instability with time and a frustrating feeling of use due to excessive use of polyol have not been solved.

In addition to such formulation technology, studies have been conducted to develop a pharmaceutical composition that can be stabilized by preparing a poorly soluble drug in the form of polymer micelles or nanoparticles using an amphiphilic block copolymer (Korean Patent Publication 10-2010- 0084399). However, since this is a cosmetic product, agglomeration between block copolymers occurs and there is still a problem of precipitation over time, so there is still a limit to stabilizing poorly soluble substances and applying them to products.

Under the above background, the present inventors have studied to develop a cosmetic composition that does not precipitate while sufficiently exhibiting the functional effect of a poorly soluble component. As a result, a poorly soluble substance using a combination of hydrogenated lecithin and an anionic surfactant It was confirmed that it can be sufficiently stabilized in the cosmetic formulation, and the present invention was completed.

It is an object of the present invention to provide a composition for stabilizing poorly soluble components comprising hydrogenated lecithin and an anionic surfactant as active ingredients.

Another object of the present invention is to provide a cosmetic composition comprising the poorly soluble component stabilizing composition and the poorly soluble component.

Another object of the present invention is to provide a method for stabilizing a sparingly soluble ingredient in a cosmetic formulation, including the step of mixing hydrogenated lecithin and an anionic surfactant.

Another object of the present invention is to provide a method for preparing a cosmetic composition in which a poorly soluble component is dissolved.

One aspect of the present invention provides a composition for stabilizing a poorly soluble component comprising hydrogenated lecithin and an anionic surfactant as active ingredients.

In general, it is difficult to stably contain poorly soluble ingredients with low solubility in both the oil phase and the aqueous phase using only the stabilizers used in cosmetics. The poorly soluble component exists in an unstable state in the cosmetic formulation, and the instability becomes higher over time, so that recrystallization proceeds and precipitation occurs.

In order to solve this problem, the present invention has developed a composition for stably including a poorly soluble component in a cosmetic formulation. By mixing hydrogenated lecithin with an anionic surfactant, a stable structure without a high pressure emulsification process, that is, micelles A transparent formulation of low viscosity was prepared to form (micelle). In addition, it is characterized in that the separation and precipitation of the poorly soluble component is prevented by stabilizing the poorly soluble component in the stable structure.

In the present invention, "hydrogenated lecithin" refers to a hydrogenated lecithin, and serves to increase the stability of the structure. The lecithin is a representative naturally derived surfactant and is meant to encompass a group of yellowish-brown fatty substances occurring in animal and plant tissues composed of phosphoric acid, choline, fatty acids, glycerol, glycolipids, and triglyceride phospholipids. In the present invention, lecithin is yolk, It includes all natural derived lecithin and synthetic lecithin extracted from animals and plants such as soybeans and corn, and microorganisms such as E. coli. Specifically, as an example of lecithin, natural phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, rizophosphatidylcholine, sphingomyelin, egg yolk 　 lecithin, soybean 　 lecithin 　, or dilauroylphosphatidyl choline, dimyristol Synthesis of palmitoylphosphatidylcholine, distearoylphosphatidylcholine, dioleoylphosphatidylcholine, palmitoylphosphatidylcholine, and oleoylphosphatidylcholine 　 lecithin 　, and the like, but are not limited thereto. In general, the naturally-derived lecithin may have a phosphatidylcholine content of 23 to 95% by weight and a phosphatidylethanolamine content of 20% by weight or less, but is not limited thereto.

Hydrogenated lecithin of the present invention may be used in a hydrogenated phosphatidylcholine (hydrogenated phosphatidylcholine) content of 10 to 99% by weight, specifically 50 to 90% by weight, but is not limited thereto.

When hydrogenated lecithin is used alone as a stabilizer in a cosmetic formulation, a liposome-shaped structure is formed. However, since such a structure has an open shape and the flexibility of the structure itself is high, it is difficult to maintain the shape such as the structure is easily deformed or broken. Accordingly, it is difficult to secure the stability of a poorly soluble substance, and the stability changes over time. In the present invention, this problem is solved by using an anionic surfactant together with hydrogenated lecithin.

The hydrogenated lecithin may be included in an amount of 0.1 to 20% by weight based on the total weight of the composition for stabilizing a poorly soluble component, specifically 0.3 to 10% by weight, 0.5 to 5% by weight, or 1 to 5% by weight. , Is not limited thereto.

If the content of hydrogenated lecithin is less than 0.1% by weight, poorly soluble ingredients may not be sufficiently dissolved, resulting in a problem of precipitation and precipitation of poorly soluble ingredients, and if it exceeds 20% by weight, the particle size of the structure increases and the formulation becomes unstable. Problems can arise.

In the present invention, "anionic surfactant" refers to a surfactant containing only anionic functional groups as an ionic or ionizable group. When mixed with hydrogenated lecithin, anionic surfactant forms a low-viscosity transparent formulation, and it helps to form a stable structure with lecithin by adjusting the packing parameter of hydrogenated lecithin. It is to prevent separation and precipitation of poorly soluble components by stabilizing the poorly soluble components through the structure prepared as described above.

Can be used without being limited to the conventional anionic surfactants known in the art In the present invention, the anionic functional group that specifically included in the anionic surfactant is specifically _{^{PO 4 3-, -CO 2 -,}} -SO _{^{3 -, -OSO 3 -, -HPO}} 3 -, -PO 3 2-, -HPO 2 -, -PO 2 2-, -PO -, or can be a combination thereof, specifically, a phosphate (PO ₄ ^3- ); Or metal salts of carboxylic acids, such as sodium salts, potassium salts, ammonium salts, magnesium salts, specifically sodium salts of carboxylic acids; Or it may be a combination thereof, but is not limited thereto. In addition, as long as it is mixed with hydrogenated lecithin to form a stable structure, it is not limited to the type and can be used.

Specifically, anionic surfactants are amino acid-derived surfactants, alkyl 　 phosphate, alkyl 　 sulfate, 　 alkyl 　 ether sulfate, 　 alkyl 　 monoglyceryl ether sulfate, 　 alkyl sulfonate, 　 alkylaryl sulfonate, 　 alkyl sulfosuccinate, 　 alkyl sulfosuccinate, 　 alkyl 　Nate, 　alkyl　sulfosuccinate, 　alkyl　amidosulfosuccinate, 　alkyl　carboxylate,　alkyl　amidoether carboxylate,　alkyl　succinate, fatty acyl sarcosinate, fatty acyl amino acid, fatty acyl alkyl taurate or fatty acid It may be a combination of these, and specifically, may be an alkyl phosphate, but is not limited thereto.

The amino acid-derived surfactant is derived from a carboxylate salt of an amino acid, and specifically, sodium dilauramidoglutamide lysine having a glutamic acid-lysine-glutamic acid structure derived from lysine may be included.

The alkyl phosphate is cetyl phosphate, PPG-10 cetyl phosphate, PPG-5-ceteth-10 phosphate, oleth-3 phosphate, Oleth-10 phosphate, ceteth-10 phosphate, ceteth-10 phosphate, dicetyl phosphate, stearyl phosphate ) Or a mixture thereof, and more specifically, cetyl phosphate, but is not limited thereto.

Specifically, for the purposes of the present invention, the anionic surfactant may be cetyl phosphate, sodium dilauramidoglutamide lysine, or a mixture thereof, and by mixing the material with hydrogenated lecithin, a poorly soluble component is incorporated in the cosmetic composition. In the stabilizing composition can be prepared.

In the present invention, the anionic surfactant may be included in 0.001 to 4% by weight based on the total weight of the composition for stabilizing poorly soluble components, specifically 0.01 to 2% by weight, 0.2 to 1.0% by weight, or 0.1 to 0.5% by weight It may be included as, but is not limited thereto.

If the content of the anionic surfactant is less than 0.001% by weight, a transparent formulation may not be prepared because the packing parameters of the hydrogenated lecithin cannot be adjusted, and if the content is more than 4% by weight, the anionic surfactant may be precipitated. .

The stability of the composition may vary depending on the mixing ratio of the hydrogenated lecithin and the anionic surfactant contained in the composition for stabilizing the poorly soluble component of the present invention. In addition, the mixing ratio with hydrogenated lecithin, which maximizes the stability of the composition, may vary depending on the type of anionic surfactant.

Specifically, when the anionic surfactant is cetyl phosphate, the mixing ratio of the hydrogenated lecithin and the anionic surfactant may be 1: 0.005 to 40 by weight, and specifically 1: 0.02 to 1, 1: 0.05 to It may be 1, 1: 0.2 to 1, 1: 0.2 to 0.5, 1: 0.2 to 0.3, 1: 0.2 to 0.25, but is not limited thereto.

In addition, when the anionic surfactant is sodium dilauramidoglutamide lysine, the mixing ratio of the hydrogenated lecithin and the anionic surfactant may be 1: 0.005 to 40 by weight, and specifically 1: 0.1 to 2 , 1: 0.3 to 2, 1: more than 0.6 and 1: 2 or less, 1: more than 0.6, 1: 1 or less, 1: more than 0.6, 1: 0.8 or less, 1: 0.8 to 1: 1, but is not limited thereto.

The composition for stabilizing poorly soluble components of the present invention may additionally contain oil. When an oil is additionally included in the composition for stabilizing poorly soluble components of the present invention, the stabilizing effect of the poorly soluble component may be higher, and the oil may be used without limitation, an oil commonly used in the art.

Specifically, the oil may be a hydrocarbon-based oil, an ester-based oil, a silicone oil, or a mixture thereof, but is not limited thereto. Hydrogenated polyisobutene, hydrogenated polydecene, paraffin, or a combination thereof as a hydrocarbon-based oil, dipentaerythrityrihexa C _5-9 acid ester, diisostearyl maleate, C ₁₂ as an ester-based oil _-15 Alkyloctanoate, myristylactate, cetylethinehexanoate, cetyloctanoate, isopropylmyristate, octyldodecylmyristate, hexylaurate, pentaerythryltetraethylhexanoate, diglycer Riltriisostearate or a combination thereof, as a silicone oil, dimethicone, cyclomethicone, polydimethylsiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, Tetradecamethylhexasiloxane, octamethyltrisiloxane, or a combination thereof may be used, and a hydrogenated polyisobutene may be used for the purposes of the present invention, but is not limited thereto.

In an embodiment of the present invention, when a composition for stabilizing a poorly soluble component including hydrogenated polyisobutene along with hydrogenated lecithin and cetyl phosphate is prepared and included in the cosmetic formulation with the poorly soluble component, after preparation 4 It was confirmed that the poorly soluble ingredients were stably dissolved for a long period of time because the properties of the cosmetic formulation were maintained and precipitation did not occur even after weeks had passed (Table 7).

Another aspect of the present invention provides a cosmetic composition comprising the poorly soluble component stabilizing composition and the poorly soluble component.

"Composition for stabilizing poorly soluble components" is as described above.

In the present invention, the "poorly soluble component" refers to a substance that is not sufficiently soluble in both water or oil and is present unstable, and is used in cosmetic compositions to impart useful effects to the skin such as wrinkle improvement, skin whitening, and skin moisturization. I can.

Specifically, the poorly soluble components included in the composition of the present invention are cedrol, formononetin, magnolol, honokiol, phloretin, ceramide, Centella asiatica quantitative extract, fisetin, daidzein, genistein, glycitein, adenosine, polydatin, retinol, gamma- Aminobutyric acid, arbutin, macelignan, acetyl phytosphingosine, hydroquinone, hydroxyanisole, ascorbic acid acid), kojic acid, and retinoids, may be one or more selected from the group consisting of, and specifically, cedrol, but is not limited thereto. As long as it is an ingredient commonly used in the art to provide beneficial effects to the skin, it is not limited to the type and can be applied to the present invention.

In one embodiment of the present invention, it was confirmed that sedrol could be prevented from sedimentation by including it in a cosmetic formulation with a mixture of hydrogenated lecithin and cetyl phosphate. As described above, the cosmetic composition of the present invention has an effect of stably including a poorly soluble component to prevent its separation and precipitation, and specifically has an advantage that separation and precipitation do not occur under a temperature condition of -20 to 60°C. That is, the cosmetic composition of the present invention can maintain a stable form for a long period of time even at room temperature as well as low and high temperature conditions.

The composition for stabilizing poorly soluble components of the present invention can stabilize poorly soluble components over various formulations from a high viscosity formulation to a low viscosity formulation. The cosmetic composition containing the sparingly soluble component of the present invention can be formulated into any formulation conventionally prepared in the art, and has various applications such as high viscosity cream, low viscosity skin, lotion, essence, mist, spray formulation, etc. It is possible.

For example, skin, lotion, essence, cream or eye cream, solution, external ointment, foam, nutrient lotion, softening lotion, pack, softening water, emulsion, makeup base, soap, liquid cleaning agent, bath agent, sunscreen cream, sun oil, Suspension, emulsion, paste, gel, powder, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, can be prepared in a formulation selected from the group consisting of a patch and spray, but is not limited thereto.

In addition, the cosmetic composition of the present invention may additionally include one or more cosmetically acceptable carriers formulated in general skin cosmetics, and as common ingredients, for example, oil, water, surfactant, moisturizer, lower alcohol, A thickener, a chelating agent, a colorant, a preservative, a fragrance, and the like may be appropriately blended, but are not limited thereto. The cosmetically acceptable carrier included in the cosmetic composition of the present invention varies depending on the formulation.

Another aspect of the present invention provides a method of stabilizing a sparingly soluble ingredient in a cosmetic formulation, including the step of mixing hydrogenated lecithin and an anionic surfactant.

"Hydrogenated lecithin", "anionic surfactant", and "poorly soluble component" are as described above.

Specifically, a poorly soluble component can be stabilized in a cosmetic composition by mixing a composition obtained by mixing hydrogenated lecithin and an anionic surfactant together with a poorly soluble component.

Hydrogenated lecithin and anionic surfactant can be added sequentially, in reverse order, or simultaneously, and the poorly soluble component is added after mixing both hydrogenated lecithin and anionic surfactant, or poorly soluble component before mixing Is first mixed with hydrogenated lecithin or anionic surfactant, and then the remaining ingredients may be added and mixed. Finally, if a cosmetic composition containing all of hydrogenated lecithin, anionic surfactants, and poorly soluble components can be prepared to stabilize the poorly soluble components, the timing and order of mixing by adding these are not limited.

The anionic surfactant may be cetyl phosphate, sodium dilauramido glutamide lysine, or a mixture thereof.

Another aspect of the present invention is (S1) adding a poorly soluble component, hydrogenated lecithin, and anionic surfactant to a solvent; And (S2) adding the resultant of the step (S1) to an aqueous phase; and a method for preparing a cosmetic composition in which a poorly soluble component is dissolved.

The anionic surfactant may be cetyl phosphate, sodium dilauramido glutamide lysine, or a mixture thereof.

"Hydrogenated lecithin", "anionic surfactant", and "poorly soluble component" are as described above.

The cosmetic composition prepared by the manufacturing method of the present invention stably contains poorly soluble components, and thus can be stably maintained without separation and precipitation of poorly soluble components for a long time in various formulations and temperature conditions.

The composition for stabilizing a poorly soluble component of the present invention stabilizes the poorly soluble component in a cosmetic formulation to prevent separation and precipitation. Accordingly, it provides a cosmetic composition containing poorly soluble ingredients having various types of formulations by overcoming the limitations of poorly soluble ingredients that were difficult to apply to cosmetic compositions due to precipitation problems with time.

1 is a photograph showing formulation turbidity according to the weight ratio of hydrogenated lecithin and cetyl phosphate.
2 is a photograph of observing the stability over time of Example 10 and Comparative Example 1 with a microscope.

Hereinafter, examples, etc. will be described in detail to aid understanding of the present invention. However, the embodiments according to the present invention may be modified in various forms, and the scope of the present invention should not be construed as being limited to the following examples. The embodiments of the present invention are provided to more completely explain the present invention to those of ordinary skill in the art.

Experimental Example 1. Confirmation of formulation properties and turbidity of a composition for stabilizing poorly soluble components

1-1. Preparation of a composition for stabilizing poorly soluble components

As shown in Table 1 below, a cosmetic composition containing various types and formulations of ingredients was prepared.

First, the oil phase and the aqueous phase were heated to 65° C. and dissolved. The oil phase was slowly added while stirring the aqueous phase with a homomixer of 2000 rpm. After the oil phase was completely added, the mixture was stirred for 3 minutes with a homomixer of 2000-2500 rpm, and then cooled to 28°C to prepare. The composition for stabilizing the poorly soluble component was prepared in a skin formulation.

division Raw material name Example 1 Example 2 Example 3 Example 4 Example 5 Paid ethanol 2 2 2 2 2 Dipropylene glycol One One One One One Hydrogenated Lecithin One One One One One Cetyl phosphate 0.05 0.1 0.15 0.2 0.25 incense 0.1 0.1 0.1 0.1 0.1 Awards Purified water Balance Balance Balance Balance Balance Arginine 0.025 0.05 0.08 0.1 0.13 glycerin 8 8 8 8 8 Propanediol 5 5 5 5 5 1.2-hexanediol 1.5 1.5 1.5 1.5. 1.5 Panthenol 1.5 1.5 1.5 1.5 1.5

division Raw material name Example 6 Example 7 Example 8 Paid ethanol 2 2 2 Dipropylene glycol One One One Hydrogenated Lecithin One One One Sodium dilauramidoglutamide lysine 0.3 0.6 0.8 incense 0.1 0.1 0.1 Awards Purified water Up to 100 Up to 100 Up to 100 glycerin 8 8 8 Propanediol 5 5 5 1,2-hexanediol 1.5 1.5 1.5 Panthenol 1.5 1.5 1.5

1-2. Measurement of formulation properties and turbidity immediately after manufacture

In order to check whether the formulation of the composition for stabilizing poorly soluble components prepared in Preparation Example 1 was formed transparently, the properties were observed immediately after preparing the composition in Preparation Example 1. To compare the formulation properties, the degree of turbidity was visually checked and the turbidity was measured using a turbidimeter. The turbidity was measured using the HACH TL2350 model, which measures turbidity using the light scattering method, and is expressed as an average value of a total of five measurements. Each of the examples was measured at 25°C. The results are shown in Table 3.

Example 1 Example 2 Example 3 Example 4 Example 5 Example
6 Example
7 Example
8 Appearance suspension Semi-suspended Translucent Transparency Transparency suspension Transparency Transparency Turbidity value (NTU) 1052 305 52.77 35.60 12.10 1120 38 16.20

As can be seen in Table 3 and FIG. 1, it was confirmed that the higher the content of cetyl phosphate or sodium dilauramidoglutamide lysine compared to the content of hydrogenated lecithin, the more transparent the composition. Both the results of observation with the naked eye and the measurement of turbidity appeared as follows.

1-3. Comparison of formulation properties and turbidity by time

In order to find the conditions of hydrogenated lecithin and anionic surfactant suitable for stabilizing poorly soluble components, the formulation stability of the cosmetic compositions of Examples 1 to 8 over time was evaluated. Formulation properties comparison experiment was performed in the same manner as in Experimental Example 1, and the results are shown in Tables 4 and 5.

Example 1 Example 2 Example 3 Example 4 Example 5 Immediately after manufacturing
Turbidity (NTU) suspension
1052 Semi-suspended
305 Translucent
52.77 Transparency
35.60 Transparency
12.10 Next day (room temperature)
Turbidity (NTU), room temperature
Turbidity (NTU), -20℃ suspension
1232
1488 suspension
380
450 Translucent
60.22
112.20 Transparency
36.12
45.21 Transparency
12.68
16.74 1 week after manufacture (room temperature) turbidity (NTU), room temperature
Turbidity (NTU), -20℃ suspension
1300
1670 suspension
412
705 suspension
53.24
705 Transparency
35.16
44.04 Transparency
15.10
20.48 4 weeks after manufacturing (room temperature) turbidity (NTU), room temperature
Turbidity (NTU), -20℃ suspension
1392
1710 suspension
410
762 suspension
52.76
762 Transparency
40.10
46.10 Transparency
16.88
24.04

Example 6 Example 7 Example 8 Turbidity immediately after manufacturing (NTU) suspension
1120 Transparency
38 Transparency
16.20 Next day (room temperature) turbidity (NTU), room temperature
Turbidity (NTU), -20℃ suspension
1200
1420 Translucent
50.2
52 Transparency
16.22
21.20 1 week after manufacture (room temperature) turbidity (NTU), room temperature
Turbidity (NTU), -20℃ suspension
1250
1580 Translucent
54
60.2 Transparency
18.42
25.20 4 weeks after manufacturing (room temperature) turbidity (NTU), room temperature
Tick degree (NTU), -20℃ suspension
1340
1740 Translucent
54.6
67 Transparency
18.80
27.32

As shown in Table 4, as the content of cetyl phosphate increased relative to the content of hydrogenated lecithin, the properties did not change under room temperature conditions and remained transparent. On the other hand, in the case of Examples 1 to 3 in which the cetyl phosphate content was relatively low, it was confirmed that the properties changed as time passed, resulting in turbidity.

On the other hand, when comparing the long-term stability, in Examples 1 to 3 in which cetyl phosphate was applied at 0.15% by weight or less when hydrogenate lecithin was 1% by weight, the properties changed within 1 week of preparation from the next day, resulting in turbidity, and -20°C. Suspension also occurred in stability.

On the other hand, in Examples 4 and 5 in which cetyl phosphate was applied in an amount of 0.2% by weight or more, properties were maintained even after 4 weeks of preparation. This suggests that the weight ratio of hydrogenated lecithin and cetyl phosphate is important, and the stability of the composition for stabilizing poorly soluble components is maintained only when the weight of cetyl phosphate is 0.2 parts by weight or more relative to 1 part by weight of hydrogenated lecithin.

In addition, as shown in Table 5, as the content of sodium dilauramidoglutamide lysine relative to the hydrogenated lecithin content increased, the properties did not change and the transparent state was maintained under room temperature conditions. On the other hand, in the case of Examples 6 to 7 in which the content of sodium dilauramidoglutamide lysine was relatively low, it was confirmed that the properties changed as time passed, resulting in turbidity.

Comparing long-term stability, in Examples 6 to 7 in which sodium dilauramidoglutamide lysine was applied at 0.6% by weight or less when hydrogenated lecithin was 1% by weight, the properties changed from the next day, resulting in turbidity and -20°C. Suspension also occurred in stability.

On the other hand, in Example 8 in which sodium dilauramidoglutamide lysine was applied in an amount greater than 0.6% by weight, properties were maintained even after 4 weeks of manufacture. It is important to note that the weight ratio of hydrogenated lecithin and sodium dilauramidoglutamide lysine is important. It suggests that the stability is better.

Experimental Example 2. Comparison of formulation properties and stability of a cosmetic composition containing poorly soluble ingredients

2-1. Preparation of cosmetic composition containing poorly soluble ingredients

From Experimental Example 1, it was confirmed that the composition for stabilizing the poorly soluble component of Example 4 in which the mixing ratio of hydrogenated lecithin and anionic surfactant was 1:0.2 was the most excellent, and further, the poorly soluble component of Example 4 An actual cosmetic composition was prepared by applying a poorly soluble component to the stabilizing composition.

로 가열하여 용해하였다. 수상을 호모믹서 2000rpm으로 교반하면서 유상을 서서히 첨가하였다. 유상을 완전히 첨가한 후 호모믹서 2000~2500rpm으로 3분간 교반한 후 28

까지 냉각하여 제조하였다. 해당 난용성 효능 성분을 포함하는 화장료 조성물은 스킨 제형으로 제조하였다.Specifically, a cosmetic composition was prepared using the ingredients and contents shown in Table 6 below. First, 65 awards and paid awards

It was heated and dissolved. The oil phase was slowly added while stirring the aqueous phase with a homomixer of 2000 rpm. After the oil phase was completely added, stirred at 2000~2500rpm in a homomixer for 3 minutes

It was prepared by cooling to. The cosmetic composition containing the poorly soluble component was prepared in a skin formulation.

division Raw material name Example 9 Example 10 Example 11 Comparative Example 1 Comparative Example 2 Paid ethanol 2 2 2 2 2 Dipropylene glycol One One One One One Hydrogenated Polyisobutene - 0.2 0.2 - - Sedrol 0.05 0.05 0.1 0.05 0.1 Hydrogenated Lecithin One One One One One Cetyl phosphate 0.2 0.2 0.2 - - PEG-40 Hydrogenated Castor Oil - - - 0.3 0.3 incense 0.1 0.1 0.1 0.1 0.1 Awards Purified water Balance Balance Balance Balance Balance Arginine 0.1 0.1 0.1 - - glycerin 8 8 8 8 8 Propanediol 5 5 5 5 5 1.2-hexanediol 1.5 1.5 1.5 1.5. 1.5 Panthenol 1.5 1.5 1.5 1.5 1.5

2-2. Formulation properties and stability comparison

Formulation stability of the cosmetic compositions of Examples 9 to 11 and Comparative Examples 1 to 2 were evaluated in order to find suitable conditions for the poorly soluble component (Sedrol). Stability evaluation was evaluated with the naked eye and a microscope by capping and sealing a transparent plastic container and storing at room temperature. The results are shown in Table 7 below.

Example 9 Example 10 Example 11 Comparative Example 1 Comparative Example 2 Immediately after manufacture Transparency Transparency Transparency Transparency Transparency Next day (room temperature) Maintain the appearance Maintain the appearance Maintain the appearance Maintain the appearance Precipitation 1 week of manufacture (room temperature) Maintain the appearance Maintain the appearance Maintain the appearance Precipitation Precipitation Manufacturing 4 weeks (room temperature) Precipitation Maintain the appearance Maintain the appearance Precipitation Precipitation

As shown in Table 7 above, in Examples 9 to 11 using hydrogenated lecithin and cetyl phosphate, precipitation was not well performed under room temperature conditions. On the other hand, in Comparative Example 2 in which the cedrol content was increased when cetyl phosphate was not added, precipitation occurred from the first day of preparation.

When comparing the long-term stability, precipitation occurred in both Comparative Examples 1 and 2 of the general solubilized formulation to which cetyl phosphate was not added within 1 week of preparation. On the other hand, in the case of Example 9 without the hydrogenated polyisobutene, precipitation occurred 4 weeks after preparation. Examples 10 and 11 to which the hydrogenated polyisobutene was applied were not precipitated and maintained their properties even after 4 weeks of preparation. The stability of the formulations of Example 10 and Comparative Example 1 over time was observed with a polarizing microscope and shown in FIG. 2.

Through these results, in a cosmetic composition containing hydrogenated lecithin and cetyl phosphate, the stability of poorly soluble components such as cedrol is increased, and in addition, long-term stability when an oil such as hydrogenated polyisobutene is applied together. It was confirmed that it is more advantageous.

Experimental Example 3. Comparison of formulation properties and stability by viscosity of cosmetic composition

3-1. Preparation of low and high viscosity transparent cosmetic composition

A transparent cosmetic composition having low viscosity and high viscosity was prepared with the ingredients and contents shown in Table 8 below. The manufacturing method was carried out in the same manner as in Experimental Example 2-1.

division Raw material name Example 12 Example 13 Example 14 Paid ethanol 2 2 2 Dipropylene glycol One One One Sedrol 0.1 0.1 0.1 Hydrogenated Polyisobutene 0.2 0.2 0.2 Hydrogenated Lecithin One 4 5 Cetyl phosphate 0.2 0.8 1.0 incense 0.1 0.1 0.1 Awards Purified water 1 Balance Balance Balance Arginine 0.28 0.48 0.68 glycerin 8 8 8 Propanediol 5 5 5 1.2-hexanediol 1.5 1.5 1.5 Panthenol 1.5 1.5 1.5 Polymer phase Purified water2 20 20 20 Carbomer 0.18 0.18 0.18

3-2. Formulation properties and stability comparison

The stability of Examples 12 to 14 was evaluated in order to confirm the stability of various formulations (low viscosity and high viscosity transparent formulations) containing a poorly soluble component. Stability evaluation was observed with the naked eye by capping and sealing a transparent plastic container, storing at room temperature and -20°C conditions. The results are shown in Table 9 below.

Example 12 Example 13 Example 14 Immediately after manufacture Transparent low viscosity skin Transparent Essence Award Transparent gel cream phase Next day (room temperature)-20℃ Maintenance
No precipitation Maintain the appearance
No precipitation Maintain the appearance
No precipitation Manufacturing 1 week (room temperature) -20℃ Maintain the appearance
No precipitation Maintain the appearance
No precipitation Maintain the appearance
No precipitation Manufacturing 4 weeks (room temperature) -20℃ Maintain the appearance
No precipitation Maintain the appearance
No precipitation Maintain the appearance
No precipitation

As shown in Table 9, in all of Examples 12 to 14 of various formulations, it was confirmed that cedrol did not precipitate and remained stable until 4 weeks after preparation. That is, it was found that the cosmetic composition prepared in the present invention can stabilize poorly soluble components in various types of formulations.

From the above description, those skilled in the art to which the present invention pertains will understand that the present invention can be implemented in other specific forms without changing the technical spirit or essential features thereof. In this regard, the embodiments described above are illustrative in all respects and should be understood as non-limiting. The scope of the present invention should be construed that all changes or modifications derived from the meaning and scope of the claims to be described later rather than the above detailed description and equivalent concepts are included in the scope of the present invention.

Claims (12)

A composition for stabilizing poorly soluble components comprising hydrogenated lecithin and an anionic surfactant as active ingredients. The composition of claim 1, wherein the anionic surfactant is cetyl phosphate, sodium dilauramidoglutamide lysine or a mixture thereof. The composition of claim 1, wherein the mixing ratio of the hydrogenated lecithin and the anionic surfactant is 1: 0.005 to 40 by weight. The composition of claim 1, wherein the hydrogenated lecithin is contained in an amount of 0.1 to 20% by weight based on the total weight of the composition for stabilizing poorly soluble components. The composition for stabilizing poorly soluble components according to claim 1, wherein the anionic surfactant is contained in an amount of 0.001 to 4% by weight based on the total weight of the composition for stabilizing poorly soluble components. The composition of claim 1, wherein the composition further comprises an oil. A cosmetic composition comprising the composition for stabilizing the poorly soluble component of any one of claims 1 to 6 and the poorly soluble component. The method of claim 7, wherein the poorly soluble component is cedrol, formononetin, magnolol, honokiol, phloretin, ceramide, and Centella Asia. Tica Quantitative Extract, fisetin, daidzein, genistein, glycitein, adenosine, polydatin, retinol, gamma-aminobutyric Acid (γ-aminobutyric acid), arbutin, macelignan, acetyl phytosphingosine, hydroquinone, hydroxyanisole, ascorbic acid, Kojic acid (kojic acid) and one or more selected from the group consisting of retinoids (retinoids), a cosmetic composition. Mixing hydrogenated lecithin and an anionic surfactant; a method for stabilizing a sparingly soluble ingredient in a cosmetic formulation. The method of claim 9, wherein the anionic surfactant is cetyl phosphate, sodium dilauramidoglutamide lysine, or a mixture thereof, wherein the poorly soluble component is stabilized in a cosmetic formulation. (S1) adding a poorly soluble component, hydrogenated lecithin, and anionic surfactant to a solvent; And
(S2) adding the result of step (S1) to the aqueous phase;
Method for producing a cosmetic composition containing a poorly soluble component is dissolved. The method of claim 11, wherein the anionic surfactant is cetyl phosphate, sodium dilauramidoglutamide lysine, or a mixture thereof, in which a poorly soluble component is dissolved.

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