KR102248265B1 - Method for producing ceramide ball with excellent stability and ceramide ball with excellent stability produced by the same method - Google Patents

Abstract

The present invention relates to a method of manufacturing a ceramide ball having excellent stability and a ceramide ball having excellent stability manufactured by the method. The ceramide ball of the present invention can contain a high content of ceramide and has excellent stability when applied to cosmetics. Therefore, it is possible to apply ceramide, which has been limitedly applied to cosmetics of the conventional emulsion type, to various types of formulations such as skin type or cream type, and improves extremely dry and problem skin (psoriasis, atopy, etc.) by increasing the skin absorption power of ceramide. It is expected to be effective.

Description

Method for producing ceramide ball with excellent stability and ceramide ball with excellent stability and ceramide ball with excellent stability produced by the same method}

The present invention relates to a method of manufacturing a ceramide ball having excellent stability and a ceramide ball having excellent stability manufactured by the method.

The skin is an organ that covers the outside of the body, and is composed of the epidermis, dermis, and subcutis from the outside. The epidermis acts as a skin barrier against various external stimuli (dryness, ultraviolet rays, and other physicochemical stimuli). In particular, the stratum corneum, the outermost layer of the epidermis, inhibits the loss of moisture and electrolytes out of the skin, preventing drying of the epidermis, providing an environment in which the epidermis can undergo normal biochemical metabolism, and protects the human body from external physical damage and chemical substances. It plays a role in preventing bacteria, fungi, and viruses from invading the skin. The stratum corneum is composed of protein-rich keratinocytes and intercellular lipids, and intercellular lipids in the stratum corneum form a lamella structure between keratinized cells, and unlike biological membranes composed of phospholipids, ceramide, cholesterol, and free It is composed of free fatty acids and the like. Of these, ceramide is a very important component that accounts for more than 50% of the lipids in the stratum corneum, and acts as a sticky connection between keratin cells so that moisture from the skin does not fly away, thereby strengthening the skin barrier. If an abnormality occurs in the production of ceramide in the epidermis, the skin barrier function is weakened and the inherent function of the skin is deteriorated, and skin troubles and skin diseases may occur due to easy exposure to harmful substances. In the case of atopic skin or dry skin, the production of ceramide is not smooth, resulting in dead skin cells and dryness. People with dry skin or suffering from atopic symptoms usually use moisture moisturizers to improve their skin, but there are many usefulness contained in cosmetics due to skin barriers such as sebum, keratin, keratin intercellular lipids, moisture barrier, and basal cell membrane. It is difficult for people to be absorbed into the skin.

Currently, various cosmetic compositions containing ceramide are being developed, but since ceramide is not well soluble in water as it is oil-soluble or poorly soluble, it is difficult to use in water-based cosmetics and it is very difficult to be absorbed into the skin, so ceramide components and skin lipids There is a need for techniques to solubilize other active ingredients, similar to those, and to deliver them deep into the skin.

On the other hand, Korean Patent Publication No. 2014-0069931 discloses a'new similar ceramide compound and its manufacturing method', and Korean Patent No. 1794555 discloses'a cosmetic for lip protection containing natural ceramide and rosehip fruit oil as active ingredients. Composition' is disclosed, but there is no description of a method for producing a ceramide ball having excellent stability according to the present invention and a ceramide ball having excellent stability prepared by the method.

The present invention was derived from the above requirements, and the present inventors mixed a high content of ceramide with excellent skin barrier protection and moisturizing effect and lecetin having excellent skin affinity to obtain a ceramide ball in a form similar to a micelle. It was manufactured, and the prepared ceramide ball was confirmed to have excellent solubility and stability, and as a result of applying the prepared ceramide ball to various cosmetic formulations (solubilization and emulsification), the formulation stability was maintained for a long time and excellent moisturizing power was confirmed during skin testing. By doing this, the present invention has been completed.

In order to solve the above problems, the present invention (1) water, hyaluronic acid (hyaluronic acid), β-glucan (glucan), 1,2-hexanediol (hexanediol), caprylyl glycol (caprylyl glycol) and Mixing and heating lecithin, followed by stirring to prepare an aqueous solution; (2) preparing an oily solution by mixing and heating sodium acrylate copolymer/lecithin, Oenothera biennis oil, and ceramide NP; (3) preparing an emulsion by adding and stirring the oily solution of step (2) to the aqueous solution prepared in step (1); And (4) degassing the emulsion of step (3).

In addition, the present invention provides a ceramide ball with excellent stability prepared by the above method and a cosmetic composition for moisturizing and skin barrier improvement comprising the ceramide ball as an active ingredient.

Since the ceramide ball of the present invention can contain ceramide in a high content and has excellent stability and solubility, it is expected that it can be easily used in the development of various cosmetics of solubilized formulation and emulsion formulation.

1 is a photograph of centrifugation of a ceramide ball containing 1%, 3% or 7% ceramide. Red arrow; The water-soluble layer and oil layer of the ceramide ball are separated.
2 is a scanning electron microscope (Scanning) of a ceramide solution (A), a ceramide ball containing 1% ceramide (B), a ceramide ball containing 3% ceramide (C), and a ceramide ball containing 7% ceramide (D). This is a picture observed with an electron microscope).
3 is a particle size analysis result of a ceramide solution (A), a ceramide ball containing 1% ceramide (B), a ceramide ball containing 3% ceramide (C), and a ceramide ball containing 7% ceramide (D).
Figure 4 is a measurement of the zeta potential of a ceramide solution (A), a ceramide ball containing 1% ceramide (B), a ceramide ball containing 3% ceramide (C), and a ceramide ball containing 7% ceramide (D). This is the graph shown.
5 is a ceramide 0.01% (Preparation Example 1), ceramide 0.03% (Preparation Example 2) and ceramide 3% ceramide ball containing 1% (Example 1) was added to the skin cosmetics of the aqueous formulation, and then the cosmetic was centrifuged. This is a separate picture. Ceramide Skin #1, #2, and #3 represent Preparation Example 1, Preparation Example 2, and Example 1, respectively.
Figure 6 shows that after adding ceramide 0.01% (Preparation Example 1), ceramide 0.03% (Preparation Example 2), and ceramide balls 1% (Example 1) containing 3% ceramide to a skin cosmetic of an aqueous formulation, 4°C (low temperature) ; A), 25°C (room temperature; B), 45°C (high temperature; C), or cold sea conditions (-4°C; D) for 1 month.
7 is a photograph showing before and after applying a cream (Formulation Example 1) containing 10% ceramide balls containing 3% ceramide to a subject with atopy, extremely dry, sensitive, psoriasis or troubled skin conditions.

In order to achieve the object of the present invention, the present invention (1) water, hyaluronic acid (hyaluronic acid), β-glucan (glucan), 1,2-hexanediol (hexanediol), caprylyl glycol (caprylyl glycol) ) And lecithin (lecithin) mixing, heating and then stirring to prepare an aqueous solution; (2) preparing an oily solution by mixing and heating sodium acrylate copolymer/lecithin, Oenothera biennis oil, and ceramide NP; (3) preparing an emulsion by adding and stirring the oily solution of step (2) to the aqueous solution prepared in step (1); And (4) degassing the emulsion of step (3).

In the method according to an embodiment of the present invention, the method of manufacturing the ceramide ball is specifically,

(1) 75 to 90% by weight of water based on 100% by weight of the emulsion; 1-5% by weight of hyaluronic acid; 0.5-3.5% by weight of β-glucan; 0.5 to 3.5% by weight of 1,2-hexanediol; 0.05 to 0.35% by weight of caprylyl glycol; And mixing 1-5% by weight of lecithin, heating at 70-80°C, and stirring at 5,000-7,000 rpm for 1-5 minutes to prepare an aqueous solution;

(2) 0.4 to 1% by weight of sodium acrylate copolymer/lecithin; 3-7% by weight of evening primrose oil (Oenothera biennis oil); And mixing 1 to 10% by weight of ceramide NP and heating at 70 to 80°C to prepare an oily solution.

(3) preparing an emulsion by adding the oily solution of step (2) to the aqueous solution prepared in step (1) and stirring at 5,000 to 7,000 rpm for 4 to 6 minutes; And

(4) degassing the emulsion of step (3); may include, and more specifically,

(1) 87.3% by weight of water based on 100% by weight of the emulsion; 1% by weight hyaluronic acid; 1% by weight of β-glucan; 3% by weight of 1,2-hexanediol; 0.3% by weight of caprylyl glycol; And mixing 1% by weight of lecithin, heating at 75° C., and stirring at 6,000 rpm for 3 minutes to prepare an aqueous solution.

(2) 0.4% by weight of sodium acrylates copolymer/lecithin; 3% by weight of evening primrose oil (Oenothera biennis oil); And mixing 3% by weight of ceramide NP and heating at 75° C. to prepare an oily solution.

(3) preparing an emulsion by adding the oily solution of step (2) to the aqueous solution prepared in step (1) and stirring at 6,000 rpm for 5 minutes; And

(4) degassing the emulsion of step (3); may include, but is not limited thereto.

In the method of manufacturing a ceramide ball according to an embodiment of the present invention, the lecithin in step (1) is a kind of phospholipid, which is a major component of cell membranes, and is a naturally derived lecithin extracted from soybeans, and phosphatidyl choline is 50~ It may be contained in 65%, but is not limited thereto.

In addition, in the method of manufacturing a ceramide ball according to an embodiment of the present invention, the ceramide of step (2) is ceramide NP, ceramide EOS, ceramide NS, ceramide EOH, ceramide AS, ceramide AP, ceramide AH, ceramide NH, It may be ceramide EOP, glucosyl ceramide, galactosyl ceramide, xylosyl ceramide, and the like, preferably ceramide NP, but is not limited thereto. The ceramide NP is 581.967 g/mol, and is widely used in moisturizing cosmetics.

The ceramide may be contained in an amount of 1 to 10% by weight based on the total weight of the ceramide ball, preferably in an amount of 2 to 4% by weight, and more preferably in an amount of 3% by weight, but is not limited thereto. When applied to a cosmetic formulation in less than 1% by weight, the effect is insignificant, and when applied to a cosmetic formulation in excess of 10% by weight, gelation is induced, resulting in poor formulation stability.

In the present invention, the ceramide ball containing 3% by weight of the ceramide can maintain a stable state that does not phase separate even if it is reacted at room temperature for a long period (30 days), and it is well dissolved in both aqueous and emulsified formulations. It has the advantage of excellent applicability. In addition, in the case of cosmetics containing ceramide balls containing 7% by weight of ceramide, the ceramide balls sink to the lower layer of the cosmetics, and in the case of cosmetics containing ceramide balls containing 1% by weight of ceramide, the ceramide balls are the lower layer of the cosmetics. In the case of cosmetics containing ceramide balls containing 3% by weight of ceramide, low temperature (4℃), room temperature (25℃), high temperature (45℃) and cold damage (-4℃) ) Even if it is reacted for a long period of time under the condition, the ceramide balls do not sink into the lower layer of the cosmetic, all dissolve and have a high moisturizing effect.

In the method of manufacturing a ceramide ball according to an embodiment of the present invention, the unit weight% means a relative value calculated as 100 for the content of the emulsion, which is the final product, and, for example, for 100 g of the emulsion, hyaluronic acid is 1 Since ~5g is added, hyaluronic acid added increases proportionally as the amount of emulsion increases.

The present invention also provides a ceramide ball having excellent stability manufactured by the above method.

In the ceramide ball of the present invention, the ceramide-containing oil phase solution was added to the lecithin-containing aqueous solution, and the mixture was stirred at 5,000 to 7,000 rpm for 4 to 6 minutes to perform micellization to form spherical particles.

The ceramide ball is in the form of a sphere that wraps (captures) ceramide with phospholipid, which is a major component of the cell membrane, and is fused or absorbed with the intercellular lipid membrane or cell membrane of the stratum corneum without an inflammatory reaction when applied to the skin to deliver ceramide deep into the skin. It has excellent stability and can be applied to solubilizing and emulsifying formulations. In addition, ceramide provides excellent moisturizing and skin barrier function improvement effects.

The present invention also provides a moisturizing and skin barrier cosmetic composition comprising the ceramide ball as an active ingredient.

The moisturizing and skin barrier improvement cosmetic composition of the present invention includes skin, skin softener, skin toner, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, eye cream, moisture cream, hand cream, essence, It may have any one formulation selected from nutritional essence, pack, cleansing foam, cleansing water, cleansing cream, body lotion, body cleanser, soap, and powder, but is not limited thereto. The cosmetic composition composed of each of these formulations may contain various bases and additives necessary and appropriate for the formulation of the formulation, and the types and amounts of these components can be easily selected by those skilled in the art.

When the formulation of the cosmetic composition of the present invention is a paste, cream or gel, animal fiber, plant fiber, wax, paraffin, starch, tragacanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, or zinc oxide as carrier components Etc. can be used.

When the formulation of the cosmetic composition of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. Propellants such as carbon, propane-butane or dimethyl ether.

When the formulation of the cosmetic composition of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene Glycol, 1,3-butylene glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan.

When the formulation of the cosmetic composition of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, and the like may be used.

When the formulation of the cosmetic composition of the present invention is a surfactant containing cleansing, as a carrier component, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, acetionate, imidazolinium derivative, methyltaurate, sarcosinate , Fatty acid amide ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty diethanolamide, vegetable oil, linoline derivative or ethoxylated glycerol fatty acid ester, and the like may be used.

The cosmetic composition of the present invention may further contain excipients including fluorescent substances, fungicides, hydrophobic substances, moisturizers, fragrances, fragrance carriers, proteins, solubilizers, sugar derivatives, sunscreen agents, vitamins, plant extracts, etc. .

Hereinafter, the present invention will be described in detail by examples. However, the following examples are merely illustrative of the present invention, and the contents of the present invention are not limited to the following examples.

Example One. Ceramide Manufacture of balls

In order to prepare the ceramide ball of the present invention, the aqueous solution and the oil phase solution containing ceramide were mixed to perform micelleization of the ceramide, and the sum of all components contained in the aqueous solution and the oil phase solution was 100% by weight.

First, water, hyaluronic acid, β-glucan, 1,2-hexanediol, caprylyl glycol, and lecithin were mixed and heated at 75°C. Then, an aqueous solution was prepared by stirring at 6,000 rpm for 3 minutes, and sodium acrylate copolymer/lecithin (LECIGEL; Lucas Meyer Cosmetics), evening primrose oil (Oenothera biennis oil), and ceramide NP (ceramide NP) NP; Doosan Glonet) was mixed and heated at 75°C to prepare an oily solution.

While slowly adding the oily solution to the prepared aqueous solution, the emulsion was emulsified by stirring with a spatula and then stirred at 6,000 rpm for 5 minutes to perform micelleization, thereby obtaining an emulsion prepared in a spherical form including ceramide. A degassing process was performed by applying pressure (0.1 MPa, about 5 minutes) to the emulsion with a vacuum dryer (Vacuum Oven; LK Labkorea). The blending ratios of the components are shown in Table 1 below. When preparing a ceramide ball containing 1%, 3% or 7% ceramide, the contents of all other ingredients are the same, and only the ceramide content is different.

Mixing ratio of ingredients used in Example 1 ingredient Mixing ratio (unit: weight%)

Awards


Purified water 87.3 Hyaluronic acid One β-glucan One 1,2-hexanediol 3 Caprylyl Glycol 0.3 lecithin One
Paid
Sodium Acrylate Copolymer/Lecithin 0.4 Evening primrose oil 3 Ceramide NP 3 Sum 100.0

Example 2. Ceramide Measuring the pH and viscosity of the ball

The pH of the ceramide ball prepared in Example 1 was measured using a pH meter. As a result, it was confirmed that the pH of the ceramide ball containing 1%, 3% or 7% ceramide was maintained at a constant level at 25°C for 30 days (Table 2).

PH measurement result of ceramide ball 1% ceramide ball 3% Ceramide Ball 7% Ceramide Ball 0 days 6.08 5.81 5.87 3 days 6.02 5.8 5.89 30 days 6.02 5.78 5.86

In addition, the viscosity of the ceramide ball containing 3% of ceramide was measured using a spindle #64 at 50 rpm and 25°C with a DV 1M viscometer. As a result, the viscosity of the ceramide ball was 3,540 cps (centi poise), and it was confirmed that the viscosity was at an appropriate level for use in cosmetics.

In addition, ceramide balls containing 1%, 3% or 7% ceramide were left at 25°C for 4 weeks, and then centrifuged for 5 minutes at 12,900 rpm. As a result, ceramide balls containing 3% ceramide and ceramide 1 It was confirmed that the ceramide ball containing% was not phase-separated for 4 weeks, but the ceramide ball containing 7% ceramide was separated from the upper layer oil after 1 week (Table 3 and FIG. 1). Through this, it was found that the ceramide ball containing 3% ceramide is in a stable state that does not undergo phase separation for a long time.

Results of centrifugation of ceramide balls Centrifugation 1% ceramide ball 3% Ceramide Ball 7% Ceramide Ball Week 0 (Day 0)
No phase separation
No phase separation No phase separation Week 1 (Day 7)
Separation of upper oil
Week 2 (Day 14) Week 3 (Day 20) Week 4 (Day 30)

Example 3. Ceramide Ball particle analysis

As a result of observing the ceramide solution and the ceramide ball prepared in Preparation Example 1 with a scanning electron microscope, the ceramide solution (Fig. 2A) and the ceramide ball containing 7% ceramide (Fig. 2D) were inconsistent shape. , Ceramide balls containing 1% ceramide exhibited a spherical shape with a size of about 100 nm (Fig. 2B), and ceramide balls containing 3% ceramide exhibited a spherical shape with a size of about 40 nm (Fig. 2C).

In addition, particle size analysis of the ceramide solution and the ceramide ball was performed using ELS-8000 OTSUKA. As a result, the diameter of the ceramide solution (Fig. 3A) was 14,300.9 nm, whereas the ceramide 1% (Fig. 3B), ceramide 3% (Fig. 3C) ) Or ceramide 7% (FIG. 3D), the diameters of the ceramide balls were 660.9 nm, 404.3 nm, and 401.8 nm, respectively. Several peaks were observed in the ceramide solution and the ceramide ball containing 1% ceramide, but one peak was observed in the ceramide ball containing 3% ceramide or 7% ceramide. It was confirmed that the peak was narrower than that of the ceramide ball containing 7%. In the above result, it means that the size of the particles is constant as there is only one peak and the width of the peak is narrower.

In addition, as a result of analyzing the zeta potential of the ceramide solution and the ceramide ball using ELS-8000 OTSUKA, ceramide 1% (Fig. 4B), ceramide 3% (Fig. 4C), or ceramide 7% (Fig. 4D) It was confirmed that the absolute value of the zeta potential of the contained ceramide balls was greater than that of the ceramide solution (FIG. 4A). In the above results, if the absolute value of the zeta potential is large, it means that the particles are stably and evenly formed. From the above results, it was considered that the ceramide ball containing 3% ceramide was the smallest in size and stable, so that it would have excellent absorption.

Example 4. Solubilization Type of formulation preparation

Lavender oil, a solubilizer (SUPERSIFIER NS-2000; CNTEC, INC., symbio solv X; Dr. Straetmans) and water were added to the aqueous solution prepared by mixing centella asiatica extract, aloe vera leaf extract, hyaluronic acid and β-glucan. The solubilization step was carried out by addition. Ceramide balls containing 3% ceramide were added to the mixture, followed by high-speed stirring to perform micelleization, and then applied to the solubilization formulation. The blending ratios of the components are shown in Table 5 below.

Mixing ratio of ingredients used in Example 4 ingredient Mixing ratio (unit: weight%) Purified water 93.7 Centella asiatica extract One Aloe Vera Leaf Extract One Hyaluronic acid One β-glucan One Lavender oil 0.3 Solubilizer One Ceramide Ball One total 100

Example 5. Preparation of emulsion type formulation

Centella asiatica extract, hyaluronic acid and beta-glucan were mixed to prepare an aqueous solution, and evening primrose oil, jojoba seed oil, safflower seed oil, camellia seed oil, sunflower seed oil, lavender oil, emulsifier (Amisol ^TM soft; Lucas Meyer Cosmetics , Biophilic H; Lucas Meyer Cosmetics, Olifeel TD OW; ROELMI HPC, Olivem 1000; HALLSTAR, Montanov 68; SEPPIC, Montanov 202; SEPPIC) and water were mixed to prepare an oily solution. After emulsifying by adding an oily solution to the aqueous solution, a ceramide ball containing 3% ceramide was added, and micelles were performed by stirring at high speed, followed by degassing, and applied to the emulsion formulation. The blending ratio of the components is shown in Table 6 below.

Mixing ratio of ingredients used in Example 5 ingredient Mixing ratio (unit: weight%)
Awards
Purified water 69.7 Centella asiatica extract One Hyaluronic acid One β-glucan One


Paid



Evening primrose oil 2 Jojoba seed oil 2 Safflower seed oil One Camellia seed oil One Sunflower seed oil One Lavender oil 0.3 Emulsifier 10 Ceramide Ball 10 total 100

Example 6. Ceramide Stability Analysis of Formulations Containing Balls

Ceramide 0.01% (Preparation Example 1), ceramide 0.03% (Preparation Example 2), or 1% ceramide balls containing 3% ceramide (Example 1) were added to the skin cosmetics of the aqueous formulation, and then the cosmetics were added at 12,900 rpm. As a result of centrifugation for 5 minutes, in Preparation Example 1 and Preparation Example 2, the ceramide balls were settled in the lower layer, but in Example 1, the ceramide balls did not settle in the lower layer, all dissolved and mixed stably (suspended) ( Fig. 5).

In addition, Preparation Example 1, Preparation Example 2, or Example 1 was 4°C (low temperature; FIG. 6A), 25°C (room temperature; FIG. 6B), 45°C (high temperature; FIG. 6C) or cold conditions (-4°C; FIG. 6D). ), as a result of reaction for 1 month, in Example 1, the ceramide balls were sufficiently dissolved until 30 days, so that no particles were observed, but in Preparation Examples 1 and 2, all ceramides did not dissolve until 0 to 30 days, so white ceramide Particles were observed.

Through the above results, it was found that the ceramide ball containing 3% of the ceramide of the present invention can be added to the cosmetic composition of the aqueous formulation, and the stability of the formulation can be maintained even when reacted at low and high temperatures for a long period of time.

Stability analysis of aqueous formulation Manufacturing Example 1 Manufacturing Example 2 Example 1 4℃ (1 month) Formulation separation Formulation separation stability 25℃ (1 month) Formulation separation Formulation separation stability 45℃ (1 month) Formulation separation Formulation separation stability Cold damage (1 month) Formulation separation Formulation separation stability

Example 7. Sensory evaluation

Sensory evaluation (Table 8) of a cream containing 10% by weight of ceramide balls containing 3% ceramide (Formulation Example 1) and a commercially available ceramide-containing cream product (Table 8) is atopic, extremely dry, sensitive, psoriasis or trouble. It was carried out on subjects from 0 years old to adults (30 people) with skin conditions, and the subjects took an appropriate amount of cream with ceramide balls added several times a day for about 2 months and spread evenly on the necessary areas such as the face or limbs. . As a result, it was confirmed that Formulation Example 1 was significantly superior to Comparative Examples 1 and 2 in terms of moisturizing persistence, skin tightening improvement, skin roughness improvement, absorption and application properties (Tables 9 and 7).

Sensory evaluation items and evaluation criteria Moisturizing Ο Very good Ο Good Ο Normal Ο bad Ο very bad Ο Not sure Moisturizing lasting Ο Very good Ο Good Ο Normal Ο bad Ο very bad Ο Not sure Skin tightening improvement Ο Very good Ο Good Ο Normal Ο bad Ο very bad Ο Not sure Skin roughness improvement Ο Very good Ο Good Ο Normal Ο bad Ο very bad Ο Not sure Absorbency Ο Very good Ο Good Ο Normal Ο bad Ο very bad Ο Not sure Spreadability Ο Very good Ο Good Ο Normal Ο bad Ο very bad Ο Not sure

Very good (5 points), good (4 points), fair (3), poor (2), very poor (1 points), not sure (0 points)

Sensory evaluation result division Formulation Example 1 Comparative Example 1 Comparative Example 2 Moisturizing lasting 5 3 2 Skin tightening improvement 5 3 2 Skin roughness improvement 5 2 3 Absorbency 5 2 3 Spreadability 5 One 2

Claims (5)

(1) 75 to 90% by weight of water based on 100% by weight of the emulsion; 1-5% by weight of hyaluronic acid; 0.5-3.5% by weight of β-glucan; 0.5 to 3.5% by weight of 1,2-hexanediol; 0.05 to 0.35% by weight of caprylyl glycol; And mixing 1 to 5% by weight of lecithin, heating at 70 to 80°C, and stirring to prepare an aqueous solution.
(2) 0.4 to 1% by weight of sodium acrylate copolymer/lecithin; 3-7% by weight of evening primrose oil (Oenothera biennis oil); And mixing 1 to 10% by weight of ceramide NP and heating at 70 to 80°C to prepare an oily solution.
(3) preparing an emulsion by adding and stirring the oily solution of step (2) to the aqueous solution prepared in step (1); And
(4) Degassing the emulsion of the step (3); Method for producing a ceramide ball having excellent stability, comprising a. delete A ceramide ball having excellent stability manufactured by the method of claim 1. A cosmetic composition for improving moisturizing and skin barriers comprising the ceramide ball having excellent stability of claim 3 as an active ingredient. The method of claim 4, wherein the cosmetic composition is a skin, skin softener, skin toner, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, eye cream, moisture cream, hand cream, essence, nutrition essence, A cosmetic composition, characterized in that it is prepared in any one formulation selected from the group consisting of a pack, cleansing foam, cleansing water, cleansing cream, body lotion, body cleanser, soap, and powder.

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