KR100772341B1 - Cosmetics containing niosome stabilized Phellodendron amurense, Cortex mori, Radix polygoni multiflori and Radix glycyrrhizae extracts and Method thereof - Google Patents
Cosmetics containing niosome stabilized Phellodendron amurense, Cortex mori, Radix polygoni multiflori and Radix glycyrrhizae extracts and Method thereof Download PDFInfo
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Abstract
본 발명은 피부 보습 및 피부 침투 효과가 우수한 생약 추출물을 안정화시킨 니오좀 및 이를 함유하는 색조 화장료 조성물에 관한 것으로, 황백(Phellodendron amurense), 상백피(Cortex mori), 하수오(Radix polygoni multiflori), 감초(Radix Glycyrrhizae )추출물을 니오좀에 안정화하여 유효 성분을 극대화하고, 제형에 따라 니오좀을 파우더에 표면 처리함으로써 파우더의 밀착력, 퍼짐성, 지속력 등을 향상시키는 생약 추출물을 안정화시킨 니오좀 및 이를 함유하는 색조 화장료에 관한 것이다.
The present invention relates to a niobium stabilized herbal extract excellent in skin moisturizing and skin penetration effect and a color cosmetic composition containing the same. Radix Glycyrrhizae) Niosomes stabilized extracts to niosomes to maximize the active ingredient, and stabilized herbal extracts to improve the adhesion, spreading, and persistence of powders by surface treatment of niosomes on powders according to the formulation It is about cosmetics.
Description
본 발명은 생약 추출물을 안정화시킨 니오좀을 함유하는 색조 화장료 조성물및 제조방법에 관한 것이다.The present invention relates to a color cosmetic composition and a manufacturing method containing niosomes stabilized herbal extracts.
건강한 피부를 가진 사람들은 피부세포의 생리활성이 활발하여 진피(Dermis)에 있는 섬유아세포(fibroblast)에서 피부탄력 증진 및 주름형성을 억제하는데 중요한 역할을 하는 콜라겐(collagen)의 합성 및 피부수분유지에 필수적인 히아루론산(Hyaluronic acid)을 포함한 당단백질류인 GAGS(Glycos aminoglycans)의 합성이 활발하여 피부에 탄력성, 부드러움, 유연성 및 보습성을 부여한다. 또한, 표피(Epidermis)에서는 기저세포(basal layer cell)의 증식(proliferation)이 활발하고, 피부세포간의 결합을 강화시키는 라미닌, 인테그린, 데스모좀과 같은 결합단백질(Adhesion protein)의 생성이 균형적으로 이루어져 피부 세포조직을 강화시켜 건강한 피부를 유지해 준다. People with healthy skin are active in the synthesis and collagen maintenance of collagen (collagen), which plays an important role in promoting skin elasticity and suppressing wrinkle formation in fibroblasts of dermis due to the active physiological activity of skin cells. Synthesis of glycosaminoglycans (GAGS), a glycoprotein containing essential hyaluronic acid, is active to give skin elasticity, softness, flexibility and moisturizing properties. In epidermis, the proliferation of basal layer cells is active, and the production of adhesion proteins such as laminin, integrin, and desmosome, which enhance the binding between skin cells, is balanced. It strengthens skin tissue and keeps healthy skin.
그러나, 현대인의 피부는 외부의 각종 유해 환경 및 스트레스에 노출되어 다양한 손상을 받고 있으며, 나이가 들면서 피부의 생리활성이 저하되고 손상된 피부의 회복속도가 느려지면서 피부는 탄력저하, 건조, 주름형성, 칙칙함 등의 다양한 피부노화 현상을 맞게 된다. However, the skin of modern man is exposed to various harmful environment and stresses and suffers various damages. As the body ages, the skin's physiological activity decreases and the damaged skin's recovery rate slows down, the skin loses elasticity, dryness, wrinkle formation, Various skin aging symptoms such as dullness are encountered.
따라서 상기와 같은 노화증세를 개선하기 위해 다양한 화장료가 개발되어지고 있으며, 상기와 같은 개발의 일환으로 제약, 화장품 및 식품 등에서 생리활성 성분이 깨지지 않고 안정하게 전달될 수 있고 지용성, 수용성 생리활성 성분을 모두 내포시킬 수 있는 리포좀이 이용되고 있다.Therefore, various cosmetics have been developed to improve the aging symptoms as described above, and as part of the above development, bioactive components in pharmaceuticals, cosmetics, and foods can be delivered without breaking, and fat-soluble and water-soluble bioactive components Liposomes that can contain all of them are used.
리포좀은 크게 다막리포좀(MLV:Multilamella vesicle)과 단막리포좀(ULV:Unilamella vesicle)로 구분되고, 상기 ULV는 대단막리포좀(Large Unilamella vesicle)과 소단막리포좀(Small Uni lame lla vesicle)으로 나눌 수 있다. Liposomes are largely divided into multi-lamellar lipicles (MLV) and monolamellar vesicles (ULV: Unilamella vesicles). .
상기 MLV, LUV, SLV는 각각 그 크기가 400-3,500nm, 100-1,000nm, 20-50nm이고 리포좀 안에 내포시킬 수 있는 량은 5-15%, 36-65%, 0.5-1.0%이다. 생리활성 물질을 내포시킬 수 있는 양은 LUV가 가장 많으나 불안정하고, SLV는 가장 안정하나 내포시킬 수 있는 양이 적다. 또한, 사람의 피부 구조는 다막(Multilamella)의 구조를 갖고 있어 MLV가 피부 친화력이 있으나 크기가 너무 커 피부 침투가 어렵다. The MLV, LUV, and SLV are 400-3,500 nm, 100-1,000 nm, and 20-50 nm in size, respectively, and the amounts that can be contained in liposomes are 5-15%, 36-65%, and 0.5-1.0%. The amount of bioactive substances that can be contained is the most LUV but unstable, SLV is the most stable but the amount that can contain less. In addition, the human skin structure has a structure of a multilamellar (Multilamella) MLV has a skin affinity, but the size is too large, it is difficult to penetrate the skin.
상기와 같은 단점들을 보완하기 위해 본 발명자들은 현재 제약 분야에서 생리활성 성분을 안정화하여 약물전달시스템(Drug Delivery System)에 이용되고 있는 리포좀의 특별한 종류인 니오좀을 사용하였으며, 상기 니오좀은 크기가 10-200nm로 피부 침투가 용이하고 리포좀에 비해 수용성 성분을 과량 내포할 수 있고 안정하다. 아울러 구성 성분도 리포좀은 인지질에 의해 형성되는 반면, 니오좀은 세라마이드(Ceramide), 세레브로사이드(Cerebroside), 스핑고미엘린(Sphingomyelin)등 스핑고리피드(Sphin golipid) 유도체를 사용하여 베시클(Vesicle)을 형성하고 이 베시클 안에 본 발명의 황백, 상백피, 하수오, 감초추출물을 안정화하여 본 발명을 완성하게 되었다.
In order to compensate for the above disadvantages, the present inventors used a niosome which is a special kind of liposome that is currently used in a drug delivery system by stabilizing a bioactive component in the pharmaceutical field, and the niosome has a size It is easy to penetrate the skin at 10-200nm and can contain excessive water-soluble components and is stable compared to liposomes. In addition, liposomes are formed by phospholipids, while niosomes use sphingolipid derivatives such as ceramide, cerebromide, sphingomyelin, and vesicles. Formed and stabilized the sulfur white, baekbaekpi, sewage, licorice extract of the present invention in this vesicle to complete the present invention.
본 발명의 목적은 상기와 같은 문제점을 해결하기 위한 것으로, 자외선, 환경오염, 스트레스, 불규칙한 생활습관 및 운동부족 등과 같은 외부 환경으로부터 저하된 피부의 생리 활성을 강화시켜 보습효과, 피부침투 효과를 증진시키는 황백(Phellodendron amurense), 상백피(Cortex mori), 하수오(Radix polygoni multiflori), 감초(Radix Glycyrrhizae )추출물을 안정화시킨 니오좀을 함유하는 색조 화장료 조성물을 제공함에 있다. An object of the present invention is to solve the above problems, by enhancing the physiological activity of the skin degraded from the external environment, such as ultraviolet rays, environmental pollution, stress, irregular lifestyle and lack of exercise, to enhance the moisturizing effect, skin penetration effect To provide a color cosmetic composition containing niosomes stabilized Phellodendron amurense, Cortex mori, Sadix polygoni multiflori, Licorice (Radix Glycyrrhizae) extract.
또한, 본 발명은 제형에 따라 니오좀의 파우더 표면 처리를 통해 퍼짐성, 지속성, 밀착력 등의 전반적인 사용성을 향상시킨 니오좀을 함유하는 색조 화장료 조성물을 제공함에 있다. In addition, the present invention is to provide a color cosmetic composition containing niosomes that improve the overall usability, such as spreadability, persistence, adhesion through the powder surface treatment of niosomes according to the formulation.
이러한 목적을 달성할 수 있도록 본 발명에서는 니오좀 내에 황백, 상백피, 하수오, 감초의 생약 추출물을 니오좀 총중량에 대해 0.1-10중량%로 함유하여 안정화시킴을 특징으로 한다. In order to achieve the above object, the present invention is characterized by stabilizing by containing 0.1-10% by weight relative to the total weight of niosome, extracts of yellow white, baekryepi, sewage, licorice in niosome.
이하, 본 발명의 구성에 대해 보다 상세하게 설명하면 다음과 같다.Hereinafter, the configuration of the present invention in more detail as follows.
본 발명은 황백(Phellodendron amurense), 상백피(Cortex mori), 하수오(Radix polygoni multiflori), 감초(Radix Glycyrrhizae )추출물을 안정화시킨 니오좀을 함유하는 색조화장료 조성물에 관한 것이다.The present invention relates to a color cosmetic composition containing niosomes stabilized with Phellodendron amurense, Cortex mori, Radix polygoni multiflori, Licorice (Radix Glycyrrhizae) extract.
황백(Phellodendri radix)은 운향과(芸香科;Rutaceae)식물인 황백(黃柏)의 수피(樹皮)로서 성질은 차며[寒] 맛이 쓰고[苦] 독이 없다. 오장과 장위 속에 몰린 열과 황달, 장치(腸痔) 등을 주로 없앤다. 설사와 이질, 적백대하, 음식창을 낫게 하고 감충을 죽이며 옴과 버짐, 눈에 열이 있어 피지고 아픈 것, 입안이 헌것 등을 낫게 하며 골증노열(骨蒸勞熱)을 없앤다. 또한, 후라보노이드(Flavo noid), 알카로이드(Alkaloid)등을 함유하므로 자외선 차단 효과와 피부에서 항균, 항염증, 항바이러스 효과가 우수하다. Phellodendri radix is the bark of Huangbaek (Rutaceae) which is a plant of Rhyanghyang. It is cold in nature and has no poison. It mainly eliminates the heat, jaundice, and devices gathered in the intestine and intestine. Diarrhea and dysentery, baekbyeongdae, heals the food window, kills the worms, scabies and ringworms, fever and soreness in the eyes, heals the sick, and the mouth is used to relieve fever. In addition, it contains flavonoids and alkaloids, so it is excellent in UV protection and antibacterial, anti-inflammatory and antiviral effects on the skin.
또한, 상백피(Cortex mori)는 뽕나무 식물인 뽕나무 근피를 말린 것으로 미백효과가 우수하며, 유해산소 제거 및 항산화 효과가 우수하다. In addition, Cortex mori is dried mulberry root of the mulberry plant is excellent in whitening effect, the removal of harmful oxygen and antioxidant effect is excellent.
또한, 하수오(Radix polygoni multiflori)는 마디풀과 식물인 하수오의 괴근을 말린 것으로 피부세포를 활성화하여 피부를 투명하고 건강하게 해 주며, 유효성분의 피부침투를 원활하게 해주는 기능이 있다.In addition, sewage (Radix polygoni multiflori) is a dried grass root of plants and plants sewage, activates skin cells to make skin clear and healthy, and has the function of smoothing skin penetration of active ingredients.
또한, 감초(Radix Glycyrrhizae )는 콩과 식물인 감초의 뿌리, 잎을 말린 것으로 항염, 항알러지 작용으로 피부 면역력을 강화시키고, 콜라겐 합성 증진으로 피부 탄력을 강화시킨다. 또한, 히아루론산 합성 증진으로 피부 보습력을 강화시키 고, 멜라닌 생성을 적극적으로 억제하는 미백효과가 있으며, 자외선을 차단하는 기능도 있다. In addition, the licorice (Radix Glycyrrhizae) is dried root and leaves of the legume licorice, anti-inflammatory, anti-allergic action to strengthen the skin immunity, collagen synthesis enhances skin elasticity. In addition, by promoting the synthesis of hyaluronic acid to strengthen the skin moisturizing effect, has a whitening effect to actively inhibit melanin production, and also has a function to block ultraviolet rays.
본 발명에서 사용된 니오좀은 안정한 비이온계면활성제, 보조유화제, 콜레스테롤, 콜레스테릴에스테르 및 소이스테롤을 혼합 사용하여 고압 유화시켜 얻어진 폐쇄된 이중층 구조를 가진 것으로, 여기에 상기 황백, 상백피, 하수오 감초로부터 얻어진 생약 추출물을 니오좀 총중량에 대해 0.1-10.0중량%로, 바람직하게 0.5-5.0중량%로 배합하여 유효 성분을 안정화하는 것이다. 이때, 니오좀 내의 황백, 상백피, 하수오, 감초 추출물은 니오좀 총 중량에 대해 각각 0.01-5.0중량%, 바람직하게 0.01-3.0중량%로 함유한다. The niosomes used in the present invention have a closed double-layer structure obtained by high pressure emulsification using a mixture of stable nonionic surfactants, co-emulsifiers, cholesterol, cholesteryl esters and soysterol, wherein the sulfur white, baekbaekpi, sewage The herbal extract obtained from licorice is formulated at 0.1-10.0% by weight, preferably 0.5-5.0% by weight, based on the total weight of niosomes to stabilize the active ingredient. At this time, the yellow white, baekbaekpi, sewage, licorice extract in niosomes are contained in 0.01-5.0% by weight, preferably 0.01-3.0% by weight relative to the total weight of niosomes.
상기 니오좀 조성에 대해 구체적으로 살펴보면 다음과 같다. Looking at the niosome composition in detail as follows.
비이온계면활성제는 폴리옥시에칠렌 알킬에테르, 폴리옥시에틸렌 알킬에스테르 및 사카로스디에스테르 등으로 단독 또는 혼용하여 니오좀의 총중량에 대하여 10-50중량%로, 바람직하게 30-40중량%로 배합한다. 이때, 비이온계면활성제만으로는 피부의 지질이 갖고 있는 역할을 기대할 수 없어 천연지질성분과 유사토록 하기 위해 글리세린 골격에 세라마이드를 결합시켜 양친매성 성질을 부여하며, 세라마이드를 니오좀의 총 중량에 대하여 0.1-10중량%로, 바람직하게 0.1-3.0중량%로 함유한다.The nonionic surfactant may be blended alone or in combination with polyoxyethylene alkyl ether, polyoxyethylene alkyl ester, saccharose diester, etc., in an amount of 10-50% by weight, preferably 30-40% by weight, based on the total weight of niosomes. . At this time, only the nonionic surfactant can not expect the role of the lipids of the skin to give the amphiphilic properties by binding the ceramide to the glycerin skeleton in order to resemble the natural lipid component, the ceramide is 0.1 to the total weight of the niosome -10 wt%, preferably 0.1-3.0 wt%.
또한, 상기 보조 유화제는 다이글리세롤로 니오좀의 총중량에 대하여 1-50중량%로, 바람직하게 2-10중량%로 배합한다.In addition, the auxiliary emulsifier is blended in 1-50% by weight, preferably 2-10% by weight based on the total weight of niosomes with diglycerol.
또한, 콜레스테롤, 콜레스테릴 에스테르 및 소이스테롤은 니오좀 총중량에 대하여 30-80%중량로, 바람직하게 50-70중량%로 배합한다. 이때, 콜레스테릴에스테르는 콜레스테릴논나노에이트, 콜레스텔릴스테아레이트, 콜레스테릴이소스테아레이트, 콜레스테릴올레이트, 콜레스테릴이소스테아릴카보네이트 등을 사용한다.In addition, cholesterol, cholesteryl ester and soysterol are blended in an amount of 30-80% by weight, preferably 50-70% by weight, based on the total weight of niosomes. At this time, cholesteryl non-nanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, cholesteryl isostearyl carbonate, etc. are used for cholesteryl ester.
상기와 같이 안정화된 니오좀은 그 제형에 있어서 특별히 한정되지 않고 유중수형 또는 수중유형 메이크업베이스, 파운데이션, 스킨커버, 립스틱, 립그로스, 페이스파우더, 투웨이케이크, 아이새도, 치크칼라, 아이브라우 펜슬류 등의 메이크업 화장료 전체 조성물에 대해 0.1-30중량%로 배합된다.Niosome stabilized as described above is not particularly limited in the formulation, water-in-oil or oil-in-water makeup base, foundation, skin cover, lipstick, lip gloss, face powder, two-way cake, eye shadow, teak color, eyebrow pencil 0.1-30 weight% with respect to the whole composition of makeup cosmetics, such as Ryu.
특히, 니오좀을 상기 제형에 그대로 사용하는 방법과 파우더에 표면 처리하여 사용하는 방법 모두에 관한 것으로, 파우더에서 니오좀 자체를 결합제로 사용했을 때 파우더의 뭉침이 촉진되는 현상과 시간 경과시 물 성분이 다소 휘발되는 단점을 표면 처리를 통하여 해결할 수 있다.In particular, the present invention relates to both the method of using niobium as it is in the formulation and the method of surface-treating the powder, and the phenomenon that the aggregation of powder is promoted when niosome itself is used as a binder in the powder and the water component over time This somewhat volatilized disadvantage can be solved through surface treatment.
다음은 상기와 같이 구성된 본 발명에 대해 아래의 실시예를 참고로 보다 구체적으로 설명된다. 그러나, 이들 실시예는 본 발명을 설명하기 위한 것으로, 본 발명의 범위가 이들 실시예에 국한되지 않는다는 것은 당 업계에서 통상의 지식을 가진 자에게 있어서 자명한 것이다. 배합량은 중량%로 나타낸다. The following is described in more detail with reference to the following embodiments of the present invention configured as described above. However, these examples are intended to illustrate the present invention, it is obvious to those skilled in the art that the scope of the present invention is not limited to these examples. Compounding amount is shown by weight%.
제조예 I : 생약 추출물의 제조방법 Preparation Example I Manufacturing Method of Herbal Extract
황백, 상백피, 하수오, 감초 추출물의 제조공정을 보다 상세히 설명하면 다음과 같다. 정제수로 세척하고 건조시킨 다음 분말화한 황백가루, 상백피가루, 하수오가루, 감초가루를 70% 에탄올 수용액 5L에 넣고 15-40℃에서 3-5일간 추출, 여과한 후, 4-15℃에서 7-10일간 방치하여 저온 숙성시키고 여과한다. 상기 추출물을 냉각 콘덴서가 달린 증류 장치를 이용하여 감압 농축, 건조하여 황백, 상백피, 하수오, 감초 추출물을 얻는다.When explaining the manufacturing process of Hwangbaek, Sangbaekpi, Sewao, licorice extract in more detail. After washing with purified water and drying, powdered yellow powder, baekbaek powder, sewage powder and licorice powder were added to 5L of 70% ethanol aqueous solution, extracted and filtered at 15-40 ℃ for 3-5 days, and filtered at 4-15 ℃. Leave at low temperature for 10 days and filter. The extract was concentrated under reduced pressure using a distillation apparatus equipped with a cooling condenser and dried to obtain an extract of yellowish white, lettuce, red sesame and licorice.
제조예 1 : 황백 추출물 제조Preparation Example 1 Preparation of Yellow White Extract
정제수로 세척하고 건조시킨 다음 분말화한 황백가루 1kg을 70%에탄올 수용액 5L에 넣고 15-40℃에서 3-5일간 추출한 후 300메쉬 여과포로 여과하고, 4-15℃에서 7-10일간 방치하여 저온 숙성시킨 후 와트만 2번 여과지로 여과한다. 상기 추출물을 냉각 콘덴서가 달린 증류장치에서 70℃로 감압 농축하고 건조하여 27.5g(건조중량)을 얻었으며, 추출 수율은 3.7±0.5%이다.After washing with purified water and drying, 1 kg of powdered sulfur white powder was added to 5L of 70% ethanol aqueous solution, extracted for 3-5 days at 15-40 ° C., filtered through a 300 mesh filter cloth, and left at 4-15 ° C. for 7-10 days. After aging at low temperature, the filter was filtered using Whatman No. 2 filter paper. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 27.5 g (dry weight), and the extraction yield was 3.7 ± 0.5%.
제조예2 : 상백피 추출물 제조Preparation Example 2: Preparation of Morus bark Extract
정제수로 세척하고 건조시킨 다음 분말화한 상백피가루 1kg을 70%에탄올 수용액 5L에 넣고 15-40℃에서 3-5일간 추출한 후 300메쉬 여과포로 여과하고, 4-15℃에서 7-10일간 방치하여 저온 숙성시킨 후 와트만 2번 여과지로 여과한다. 상기 추출물을 냉각 콘덴서가 달린 증류장치에서 70℃로 감압 농축하고 건조하여 27.5g(건조중량)을 얻었으며, 추출 수율은 3.0±0.5%이다.After washing with purified water and drying, 1kg of powdered baekbo powder was put in 5L of 70% ethanol aqueous solution and extracted at 15-40 ℃ for 3-5 days, filtered through 300 mesh filter cloth, and left at 4-15 ℃ for 7-10 days. After aging at low temperature, the filter was filtered using Whatman No. 2 filter paper. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 27.5 g (dry weight), and the extraction yield was 3.0 ± 0.5%.
제조예 3 : 하수오 추출물 제조Preparation Example 3 Preparation of Sewage Extract
정제수로 세척하고 건조시킨 다음 분말화한 하수오가루 1kg을 70%에탄올 수용액 5L에 넣고 15-40℃에서 3-5일간 추출한 후 300메쉬 여과포로 여과하고, 4-15℃에서 7-10일간 방치하여 저온 숙성시킨 후 와트만 2번 여과지로 여과한다. 상기 추출물을 냉각 콘덴서가 달린 증류장치에서 70℃로 감압 농축하고 건조하여 27.5g(건조중량)을 얻었으며, 추출 수율은 3.1±0.5%이다. After washing with purified water and drying, 1 kg of powdered sewage powder was added to 5L of 70% ethanol aqueous solution, extracted for 3-5 days at 15-40 ° C., filtered through 300 mesh filter cloth, and left at 4-15 ° C. for 7-10 days. After aging at low temperature, the filter was filtered using Whatman No. 2 filter paper. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 27.5 g (dry weight), and the extraction yield was 3.1 ± 0.5%.
제조예 4 : 감초 추출물 제조Preparation Example 4: Licorice Extract Preparation
정제수로 세척하고 건조시킨 다음 분말화한 감초가루 1kg을 70%에탄올 수용액 5L에 넣고 15-40℃에서 3-5일간 추출한 후 300메쉬 여과포로 여과하고, 4-15℃에서 7-10일간 방치하여 저온 숙성시킨 후 와트만 2번 여과지로 여과한다. 상기 추출물을 냉각 콘덴서가 달린 증류장치에서 70℃로 감압 농축하고 건조하여 27.5g(건조중량)을 얻었으며, 추출 수율은 2.8±0.5%이다.
After washing with purified water and drying, 1 kg of powdered licorice powder was added to 5 L of 70% ethanol aqueous solution, extracted for 3-5 days at 15-40 ° C., filtered through a 300 mesh filter cloth, and left at 4-15 ° C. for 7-10 days. After aging at low temperature, the filter was filtered using Whatman No. 2 filter paper. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 27.5 g (dry weight), and the extraction yield was 2.8 ± 0.5%.
제조예 II : 니오좀의 제조Preparation Example II Preparation of Niosome
제조 방법:Manufacturing method:
1) A상을 90℃까지 가온하여 균일하게 혼합, 용해시킨다.1) Warm phase A to 90 ° C to mix and dissolve uniformly.
2) 상기 1)을 45℃까지 냉각하여 B상을 넣고 혼합한 후 1000bar의 압력 조건하에서 고압유화장치(Microfludizer)에 3회 통과시켜 얻는다.
2) The above 1) is cooled to 45 ° C., B phase is mixed, and then passed through a high pressure emulsifier (Microfludizer) three times under a pressure condition of 1000 bar.
제조예 III : 니오좀의 파우더 표면 처리Preparation Example III Powder Surface Treatment of Niosome
평균 입도가 5-10㎛인 탈크, 세리사이트, 마이카, 실리카, PMMA, 나이론 파우더의 체질 안료와 평균 입도가 0.01-2㎛인 산화철, 울트라마린, D/C Red 7, 칼슘레이크 등의 유, 무기계 색소를 파우더 총 중량에 대해 85-95중량%로, 니오좀을 파우더 총 중량에 대해 0.1-10중량%로, 바람직하게 0.1-5중량%로 배합하여 고압분사 시킨 후 냉동 건조시킨다. Oils such as talc, sericite, mica, silica, PMMA, nylon powder having an average particle size of 5-10 μm and iron oxide, ultramarine, D / C Red 7, calcium lake having an average particle size of 0.01-2 μm, Inorganic pigments are blended at 85-95% by weight based on the total weight of the powder, niosomes at 0.1-10% by weight, preferably 0.1-5% by weight, and freeze-dried.
제조 방법:Manufacturing method:
1) 평균 입도가 5-10㎛인 탈크 94.5중량%를 헨셀 믹서에 투입하고 니오좀 4중량%, Polysorbate 60 0.5중량%를 투입하여 교반한 후, 이를 파우더에 7,000-8,000rpm 속도로 고속 분무하면서 균일하게 혼합시킨다. 이때, 계면활성제는 니오좀을 파우더에 용이하게 표면 처리하기 위한 것으로 HLB가 높은 Polysorbate 60를 사용하며, 고속 분무 시 입자크기는 0.01㎚이다.1) Inject 94.5% by weight of talc having an average particle size of 5-10 μm into a Henschel mixer, add 4% by weight of niobium and 0.5% by weight of Polysorbate 60, and stir, and spray the powder at a high speed of 7,000-8,000 rpm. Mix evenly. At this time, the surfactant is to facilitate the surface treatment of niosomes to the powder using a high HLB Polysorbate 60, the particle size at high speed spraying is 0.01nm.
2) 상기 1)을 동결건조방식에 의해 수성성분을 탈수시키고 5℃에서 건조시킨다.
2) The aqueous component is dehydrated by lyophilization and dried at 5 ° C.
실시예 및 비교예 I : 파운데이션Example and Comparative Example I: Foundation
제조 방법 :Method of manufacture:
1) 원료 1-6 및 원료 15를 70-75℃로 가온하여 균일하게 용해시킨다.1) The raw materials 1-6 and 15 are heated to 70-75 ° C. to dissolve uniformly.
2) 원료 7-10을 헨셀믹서로 30분간 혼합하고 암토마이져로 2회 분쇄한 후 상기 1)에 투입하여 50분간 분산시킨다. 2) The raw materials 7-10 are mixed with a Henschel mixer for 30 minutes, crushed twice with an amtomizer, and then added to 1) to disperse for 50 minutes.
3) 원료 11-14를 아지믹서로 균일하게 용해시킨 후 상기 2)에 투입하여 균일하게 용해시킨다.3) After dissolving raw material 11-14 uniformly with an azimixer, it is added to 2) above to dissolve uniformly.
4) 원료 17-21을 70-75℃로 가온하여 균일하게 혼합한 후 상기 3)에 서서히 투이하여 호모믹서로 유화시킨다. 4) The raw materials 17-21 are heated to 70-75 ° C., uniformly mixed, and slowly added to 3) to emulsify with a homomixer.
5) 상기 4)를 50℃로 냉각시킨 후 원료 16, 22를 투입하여 2차 유화 후 30℃ 로 냉각시키고 저장한다.
5) After cooling 4) to 50 ° C., raw materials 16 and 22 are added, and after secondary emulsification, the mixture is cooled to 30 ° C. and stored.
시험예 : 피부 보습효과 및 보습효과의 지속성의 비교Test Example: Comparison of Skin Moisturizing Effects and Moisturizing Effects
실시예 및 비교예에 대해서 피부 보습효과 및 보습효과의 지속성에 대해 알아보기 위해 25℃, 상대습도 45%의 공기 흐름이 없는 실내에서 건강한 여성 30명(평균연령 29.5세)을 대상으로 실시예 및 비교예 제품을 눈가를 중심으로 1일, 3회 6주간 도포하여 보습효과 및 보습효과의 지속성에 대해 알아본다. In order to examine the persistence of the skin moisturizing effect and the moisturizing effect for the Examples and Comparative Examples, 30 healthy women (average age 29.5 years) were examined in a room with no air flow at 25 ° C. and a relative humidity of 45%. Comparative Example The product is applied three times a day, three times a day, mainly around the eyes, to examine the moisturizing effect and the persistence of the moisturizing effect.
TEWAMETER TM210(C+K electronic GmbH. Germany)을 이용하여 경피수분손실량 즉, TEWL(Transepidermal Water Loss)값을 시간 변화에 따른 TEWL 값 변화량 △TEWL로 측정하고, CORNEOMETER CM 820 PC(C+K electronic GmbH. Germany)를 이용하여 표피 수분량에 따른 전기전도도의 변화로 0에서 150까지 피부의 수분량을 수치화하여 피부 보습효과를 측정하고 그 결과를 하기 표 3에 나타내었다. TEWAMETER TM210 (C + K electronic GmbH. Germany) was used to measure transdermal moisture loss, that is, TEWL (Transepidermal Water Loss) value as TEWL value change ΔTEWL over time, and CORNEOMETER CM 820 PC (C + K electronic GmbH. Germany) to measure the skin moisturizing effect by quantifying the moisture content of the skin from 0 to 150 with the change of electrical conductivity according to the epidermal moisture content, and the results are shown in Table 3 below.
아울러 본 발명의 보습효과에 대한 지속력을 알아보기 위해 실시예 및 비교예를 각각 상기 표2에 따라 제형하여 상박을 중심으로 도포하여 1시간이 지난 후, TEWAMETER TM210(C+K electronic GmbH. Germany)를 이용하여 경피수분손실량 즉, TEWL(Transepidermal Water Loss)값을 시간 변화에 따른 TEWL 값 변화량 △TEWL로 측정하고, CORNEOMETER CM 820 PC(C+K electronic GmbH. Germany)를 이용하여 표피 수분량에 따른 전기 전도도를 측정하여 보습효과의 지속성에 대해 알아보고, 그 결과를 하기 표 4에 나타내었다. In addition, in order to find out the lasting power for the moisturizing effect of the present invention, Examples and Comparative Examples were formulated according to Table 2, respectively, and after 1 hour of application to the upper arm, TEWAMETER TM210 (C + K electronic GmbH. Germany) The transdermal moisture loss (TEWL) value, ie, the TEWL value change amount ΔTEWL over time, was measured by using the quantitative analysis, and the electrical energy according to the epidermal moisture content was measured using the CORNEOMETER CM 820 PC (C + K electronic GmbH. Germany). The conductivity was measured for the persistence of the moisturizing effect, and the results are shown in Table 4 below.
상기 표 3에 나타난 바와 같이, 실시예의 △TEWL 값이 6.7㎍/cm2/hr로 보습효과가 우수함을 알 수 있고, 보습 효과 지속성에서도 경피 수분 손실량이 급감하게 되어 피부가 오랜 시간동안 촉촉함을 갖게됨을 알 수 있다. 이는 본 발명의 니오좀이 일반 유화입자보다 입자 크기가 작아 피부 침투가 용이해 피부 보습이 극대화됨을 의미하는 것이다.
As shown in Table 3, the ΔTEWL value of the embodiment is 6.7㎍ / cm 2 / hr it can be seen that the moisturizing effect is excellent, and even in the persistence of the moisturizing effect, the amount of transdermal moisture loss is drastically reduced to have the skin moisturized for a long time It can be seen that. This means that the niosome of the present invention has a smaller particle size than general emulsified particles, thereby easing skin penetration and maximizing skin moisturization.
시험예 : 피부침투효과Test Example: Skin Penetration Effect
인체 정상 섬유아세포(Human normal fibroblast) 1x105 cells/ml 세포를 인체의 결합조직을 이루는 섬유조직과 유사한 콜라겐 젤 구조에 콜라겐 수용액 3mg/ml: 5X DMEM: 2.2% 소듐바이카보네이트(Sodium bicarbonate)와 200mM Hepes 완충액이 포함된 0.05N 수산화나트륨이 7:2:1로 혼합된 배지에 접종하여 5% CO2, 37℃에서 7일 동안 배양한 것을 3㎛ 다공성 폴리카보네이트(Porous polycarbonate) 재질로된 막(Membrane)에 의해 안쪽과 바깥쪽이 구분된 플레이트(Plates)의 안쪽에 넣고 섬유아세포가 배양된 Dermal Equivalent(DE) 표면 위에 표피 각질형성세포(Epidermal Keratinocyte) 1x105 cells/ml 세포를 접종하여 EGF와 BPE가 함유된 K-SFM 배지를 안쪽과 바깥쪽에 넣고 7일 동안 배양한다. 그 후 플레이트 안쪽의 배지를 버려 공기가 배양세포의 표면에 접촉되도록 하고 바깥쪽에 10% FBS가 함유된 K-SFM과 EGF가 들어있지 않은 DMEM이 동량으로 혼합된 배지를 넣어 2주간 배양하여 다층의 표피와 진피가 형성된 인공피부를 얻는다. 여기에 본 발명의 실시예1 및 비교예1을 맨 위층의 인공피부 조직에 적용하여 4시간 배양한 후 10% FBS가 함유된 K-SFM과 EGF가 들어있지 않은 DMEM 이 동량으로 혼합된 배지에서 인공피부의 표피와 진피를 침투하여 통과된 추출물의 양을 HPLC로 분석하였다. 시험결과는 하기 표 5에 나타내었다.Human normal fibroblast 1x10 5 cells / ml Cells in collagen gel structure similar to the fibrous tissue of human connective tissue Collagen solution 3mg / ml: 5X DMEM: 2.2% Sodium bicarbonate and 200mM Inoculated in a medium mixed with 7: 2: 1 with 0.05 N sodium hydroxide containing Hepes buffer and incubated for 7 days at 5% CO 2 , 37 ° C., a membrane made of 3 μm porous polycarbonate ( 1x10 5 cells / ml of epidermal keratinocytes were inoculated onto the surface of the plate where the fibroblasts were cultured. Place K-SFM medium containing BPE inside and outside and incubate for 7 days. Afterwards, the medium inside the plate was discarded to allow the air to come into contact with the surface of the cultured cells, followed by incubating for 2 weeks in a medium in which K-SFM containing 10% FBS and DMEM without EGF were mixed in the same amount and incubated for 2 weeks. Obtain artificial skin with epidermis and dermis. Here, Example 1 and Comparative Example 1 of the present invention were applied to the artificial skin tissue of the top layer, followed by 4 hours of incubation, in a medium in which K-SFM containing 10% FBS and DMEM without EGF were mixed in the same amount. The amount of extract that penetrated the epidermis and dermis of artificial skin was analyzed by HPLC. The test results are shown in Table 5 below.
상기 표 5에 나타난 바와 같이, 니오좀을 함유한 실시예가 입자 크기가 비교예보다 작아 피부 침투가 훨씬 우수함을 알 수 있다.
As shown in Table 5, it can be seen that the Example containing niosome is much superior to the skin penetration because the particle size is smaller than the comparative example.
실시예 및 비교예 II : 투웨이 케이크Example and Comparative Example II: Two-way Cake
제조 방법 :Method of manufacture:
1) 1-8의 원료를 헨셀 믹서로 30분간 혼합한다.1) Mix 1-8 raw materials with Henschel mixer for 30 minutes.
2) 9와 11-14의 원료를 80℃로 가온하여 균일하게 용해한 후 상기 10, 15의 원료를 혼합 후 고속 분사시킨다. 2) After heating the raw materials of 9 and 11-14 at 80 ° C. to dissolve uniformly, the raw materials of 10 and 15 are mixed and sprayed at high speed.
3) 상기 2)를 헨셀믹서로 20분간 혼합한 후, 분쇄기로 분쇄한다. 3) 2) is mixed with a Henschel mixer for 20 minutes and then pulverized with a grinder.
4) 상기 3)을 여과한 후, 성형하여 제품화한다.
4) The above 3) is filtered and then molded into a product.
시험예 : 사용효과 비교Test Example: Comparison of Use Effect
본 발명의 실시예 2, 3과 비교예 2 제품에 대해 20-30대 중반의 여성 30명을 대상으로 1달간 사용한 후 밀착성, 퍼짐성, 화장지속성, 피부 건조감 방지 등의 항목에 대해 비교 품평하고 그 결과를 하기 표 7에 나타내었다. Example 2, 3 and Comparative Example 2 of the present invention for 30 women in their mid-20s and 30s after one month of use compared to the items such as adhesion, spreading, makeup persistence, preventing skin dryness The results are shown in Table 7 below.
범례: 5-아주좋음, 4-좋음, 3-보통, 2-나쁨, 1-아주나쁨
Legend: 5-very good, 4-good, 3-normal, 2-bad, 1-very bad
상기 표 7에 나타난 바와 같이, 본 발명의 실시예 2, 3의 사용효과가 전반적으로 우수하며, 특히 니오좀을 파우더에 표면 처리한 것을 사용한 실시예 2에서 가루날림, 입자 뭉침, 부드러움성의 사용 효과에 있어 더욱 우수함을 알 수 있다.
As shown in Table 7, the use effects of Examples 2 and 3 of the present invention are excellent overall, and in particular, the use of powdering, particle aggregation, and softness in Example 2 using niosome surface-treated in powder It can be seen that even better.
이상에서 살펴본 바와 같이, 황백, 상백피, 하수오, 감초 추출물을 안정화시킨 니오좀을 함유하는 색조 화장료 조성물은 보습 효과 및 피부 침투 효과를 증진시키고, 제형에 따라 니오좀을 파우더에 표면 처리함으로써 파우더의 건조감 방지, 밀착력, 퍼짐성 및 지속력을 향상시켜 제품의 품질 및 신뢰성을 향상시키는 효과가 있게 되는 것이다. As described above, the color cosmetic composition containing niobium stabilized yellow, white skin, sewage, licorice extract enhances the moisturizing effect and skin penetration effect, and the dryness of the powder by surface treatment of the niobium according to the formulation It is effective in improving the quality and reliability of the product by improving the prevention, adhesion, spreadability and durability.
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KR100434898B1 (en) * | 2001-06-26 | 2004-06-07 | 나드리화장품주식회사 | Cosmetic composition containing medical plant complex extracts stabilized with liquid crystalsome |
KR100444196B1 (en) * | 2001-06-26 | 2004-08-11 | 나드리화장품주식회사 | Cosmetic composition containing medical plant complex extracts stabilized with nanoliposome |
KR100512330B1 (en) * | 2002-08-13 | 2005-09-02 | 나드리화장품주식회사 | Cosmetic composition containing baobob extracts stabilized with nanoliposome |
KR100482694B1 (en) * | 2002-11-06 | 2005-04-14 | 주식회사 태평양 | Liposome base for trichogenousness, Cosmetic composition for trichogenousness containing the same, and Method for improving absorptance of natural ingredients for trichogenousness using the same |
KR100681703B1 (en) * | 2005-08-17 | 2007-02-15 | 주식회사 코리아나화장품 | Cosmetic composition for enhancement of skin luster comprising the mixed extract of panax ginseng, sohizophyllum commune and phellodendron amurense ruprecht stabilized in nanoliposome |
KR100702035B1 (en) * | 2006-08-30 | 2007-03-30 | (주)스피어테크 | Manufacturing Process and 3D[Three-Dimensional] Terracotta Makeup Cosmetic Composition of A Powder Cosmetic |
CN104510636A (en) * | 2013-09-26 | 2015-04-15 | 青岛锦涟鑫商贸有限公司 | Traditional Chinese medicine whitening mask |
CN104510637A (en) * | 2013-09-26 | 2015-04-15 | 青岛锦涟鑫商贸有限公司 | Chinese herbal medicine spot removing mask |
KR101626408B1 (en) * | 2014-10-16 | 2016-06-01 | 주식회사 코리아나화장품 | Cosmetic composition comprising niosome containing troxerutin |
ITUA20162223A1 (en) * | 2016-04-01 | 2017-10-01 | Linnea Sa | Topical composition including plant extracts |
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