KR20010105905A - Skin care composition containing stabilized Scultellaria baicallensis, Coptidis rhizoma, Glycyrrhiza glabra and Acanthopanax sessiliflorum with niosome - Google Patents

Abstract

A method and apparatus for encoding data (152) produces a code stream (153) of code words (190, 192, 194) where each code word includes two subsets of code bits. Each subset of code bits is constrained by a different maximum transition run constraint. In an alternative embodiment, the method and apparatus produces a code stream (153) comprised of alternating even bit locations (188) and odd bit locations (186), where the even bit locations are constrained by a different maximum run length constraint than the odd bit locations.

Description

Skin care composition containing stabilized Scultellaria baicallensis, Coptidis rhizoma, Glycyrrhiza glabra and Acanthopanax sessiliflorum with niosome}

The present invention relates to a cosmetic composition containing niosomes stabilized golden (Scultellaria baicallensis), sulfur (Coptidis rhizoma), licorice (Glycyrrhiza glabra), Ogapi (Acanthopanax sessiliflorum) extract.

Skin's physiological activity is active before aging

In fibroblasts of dermis, GAGS, a glycoprotein containing hyaluronic acid, is essential for the synthesis and metabolism of collagen, which is important for skin elasticity and wrinkle suppression, and essential for skin moisture retention. (Glucosamino-

glycans) is also active, giving skin elasticity, softness, flexibility and moisturizing properties. In epidermis, the proliferation of basal layer cells is active, and the production of adhesion protains such as laminin, integrin, and desmosome, which enhance the binding between skin cells, is balanced. It strengthens skin tissue and keeps healthy skin. However, the skin of modern man is exposed to various harmful environment and stresses and suffers various damages. As he ages, the skin's physiological activity decreases and the damaged skin's recovery rate slows down, the skin loses elasticity, dryness, wrinkle formation, and dull skin Various skin aging phenomena such as. Therefore, the biggest goal of cosmetics is to improve the aging symptoms, various cosmetics have been developed for this. In recent years, the use of natural ingredients in cosmetics has been increasing rapidly, and various skin physiological activities on natural plant ingredients have been searched for, and materials having excellent skin beauty effects have been developed. However, most herbal ingredients are not only unstable by themselves, but also have a big problem in the stability of the cosmetic when applied to the cosmetic.

In order to solve this problem, as well as the pharmaceutical field, cosmetics, foods, etc. can be delivered stably without destroying the physiologically active ingredients, and the liposomes can be contained whether the physiologically active ingredients are fat-soluble or water-soluble. Liposomes are largely divided into multi-membrane liposomes (MLV: Multilamella vesicle) and monolithic liposomes (ULV: Unilamella vesicle). MLV is 400 ~ 3500nm in size and can contain 5 ~ 15 in liposomes, LUV is 100 ~ 1,000nm and can contain 36 ~ 65 in liposomes and SLV is 20 ~ in size It is 50 nm and the amount which can be contained in a liposome is 0.5-1.0.

The amount of bioactive substances that can be contained is the most LUV but unstable, SLV is the most stable, but the amount that can contain less. In addition, the structure of human skin

Because of its structure, MLV has affinity with the skin, but is too large to penetrate the skin.

In contrast, niosome is a special kind of liposomes currently used in drug delivery systems by stabilizing physiologically active ingredients in the pharmaceutical field. It can contain excess water soluble components and is stable. In addition, liposomes are formed by phospholipids, while niosomes are ceramide, cerebromide, and sphingolipid.

(Sphingolipid) derivatives are used to form vesicles within the vesicles

Contains bioactive ingredients.

The present invention is to develop a cosmetic material with excellent skin beauty effect targeting the herbal ingredients that grow native to Korea to enhance the physiological activity of the skin degraded by age, stress, ultraviolet rays, environmental pollution, drying.

Gold of the present invention (Scultellaria baicallensis), Colidis (Coptidis rhizoma) Licorice (Glycyrrhiza glabra), Ogapi (Acanthopanax sessiliflorum) has excellent skin physiological activity. Therefore, in order to protect the skin from the external environment such as ultraviolet rays, environmental pollution and stress, irregular lifestyle, lack of exercise, etc. by stabilizing the herbal components of the present invention in niosomes, the physiological activating effect of gold, rhubarb, licorice, and organza has Maximizing as well as solving the stability in the cosmetics to complete the present invention.

It is an object of the present invention to provide a cosmetic composition containing niosomes stabilized golden, yellow lotus, licorice, agapi.

The present invention relates to a cosmetic composition containing niosomes stabilized golden, yellow lotus, licorice, organ extract.

The active ingredients of the present invention (Scultellaria baicallensis), sulfur (Coptidis rhizoma), licorice (Glycyrrhiza glabra), Ogapi (Acanthopanax sessiliflorum) extract is contained in an amount of 0.1 to 10 weight with respect to the total weight of niosomes, preferably It is 0.5 to 5.0 weight.

The amount of the extract (Scultellaria baicallensis) in the niosome-containing cosmetic composition of the present invention is contained in an amount of 0.001 to 3.0 weight based on the total weight of niosome, preferably 0.01 to 1.0.

Golden (Scultellaria baicallensis) is a nectar and perennial herbaceous plant that contains bioactive ingredients such as flavonoids, wogonin, and baicalin.The pharmacological effect is to lower the heat and cough of the heart and lungs. And stops blood. The skin has anti-allergic, antioxidant, and anti-inflammatory effects, and is excellent in removing harmful oxygen. Golden extract is obtained by washing and drying golden gold, extracting it from an organic solvent, aging it at low temperature, and then filtering and drying.

In the niosome-containing cosmetic composition of the present invention, Colicidis rhizoma extract is contained in an amount of 0.001 to 3.0% by weight, and preferably 0.01 to 1.0, based on the total weight of niosome.

Husband (Coptidis rhizoma) is a perennial herbaceous plant of the genus Minaria Jetbet, which has bioactive substances such as alkaloids and has excellent anti-inflammatory and skin improvement effects. Huangshan extract is obtained by washing and drying the yellow lotus, put it in an organic solvent, extracted in an extractor with a cooling capacitor, aged it at low temperature, and then filtered and dried.

Licorice (Glycyrrhiza glabra) extract in the niosome-containing cosmetic composition of the present invention is contained in an amount of 0.001 to 3.0% by weight relative to the total weight of niosome, preferably 0.01 to 1.0.

Licorice (Glycyrrhiza glabra) is a soybean and perennial herbaceous plant with excellent anti-inflammatory, anti-allergic, and antibacterial effects, and has an excellent effect on collagen synthesis and hyaluronic acid synthesis, which are closely related to skin elasticity, wrinkle improvement, and skin moisturizing effect. Bioactive components of licorice are glycyrrhizin, flavonoids and mannitol.

Ogapi (Acanthopanax) in the cosmetic composition containing niosomes

sessiliflorum) extract is contained in an amount of 0.001 to 5.0 weight based on the total weight of niosomes, preferably 0.05 to 2.0.

Acanthopanax sessiliflorum (Acanthopanax sessiliflorum) is a deciduous tree, also known as oakpi, and is known as ogalpi. It is a classical herb that is widely used in folk medicine as a help. Its distribution is native only to Northeast Asia.

Licorice extract and organza extract can be obtained by the same method as gold extract, washed and dried, extracted from organic solvents, aged, filtered and dried.

In the composition of the present invention, niosomes are mixed with a stable nonionic surfactant, co-emulsifier, cholesterol, Cholesteryl ester, and soy sterol. Niosome with a closed double layer structure was completed by high pressure emulsification. Nonionic surfactants include polyoxyethylene alkylether, polyoxyethylene alkylester, and saccharose diester.

Etc., and the amount is contained in an amount of 10 to 50% by weight, preferably 30 to 40% by weight, based on the total weight of niosomes. Diglycerol is used as an auxiliary emulsifier, and the amount thereof is contained in an amount of 1 to 50 weights, preferably 2 to 10 weights, based on the total weight of niosomes. Cholesterol, cholesteryl esters and soysterol are contained in an amount of 30 to 80% by weight, preferably 50 to 70% by weight, based on the total weight of niosomes, wherein cholesteryl nonano Cholesteryl-nonanoate, Cholesteryl stearate, Cholesteryl isostearate, Cholesteryl oleate, Cholesteryl isostearylcarbonate Etc. In addition to nonionic surfactants, ceramides were combined with glycerin to support the role of lipids in the skin, thus making them amphiphilic and similar to natural lipids. The ceramide used at this time is contained in an amount of 0.1 to 10% by weight relative to the total weight of niosomes, preferably 2.0 to 6.0 by weight.

The cosmetic composition of the present invention is not particularly limited in the formulation, for example, supple cosmetics, astringent cosmetics, nourishing cosmetics, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, essence, pack It may have a formulation such as.

In addition, in the cosmetic composition of each formulation as a herbal ingredient for skin improvement, herbal ingredients such as Angelica, white lotus, algae, Chinese quince, cornus, rhubarb, rhubarb, cloves, etc. Depending on the formulation or purpose of use can be suitably selected by those skilled in the art without difficulty.

Hereinafter, the configuration and effects of the present invention will be described in detail with reference to preparation examples and experimental examples, but the present invention is not intended to be limited thereto.

Preparation Example 1 Golden Extract

After washing with purified water and drying, 1kg of powdered golden powder was added to 5ℓ of 70ethanol aqueous solution, extracted for 5 days at 15 ~ 40 ℃, filtered through 300mesh filter cloth, left at 4 ~ 15 ℃ for 10 days, and then aged at low temperature. Filter with Whatman twice filter paper. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 37.5 g (dry weight), and the extraction yield was 3.8 ± 0.5.

Preparation Example 2

After washing with purified water and drying, 1 kg of powdered rhubarb powder was added to 5 L of 70 ethanol aqueous solution, extracted for 3 days in an extractor equipped with a cooling condenser, filtered through 300 mesh filter cloth, and left at 4 to 15 ° C. for 10 days to be aged at low temperature. It was then filtered through Whatman twice filter paper. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 24.9 g (dry weight), and the extraction yield was 2.5 ± 0.2.

Preparation Example 3 Licorice Extract

After washing with purified water and drying, 1 kg of powdered licorice powder was added to 5 L of 70-ethanol aqueous solution, extracted for 5 days at 15-40 ° C., filtered through a 300 mesh filter cloth, and left at 4-15 ° C. for 10 days to be aged at low temperature. Filter with Whatman twice filter paper. The extract was concentrated under reduced pressure at 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 61.1 g (dry weight), and the extraction yield was 6.1 ± 0.7.

Preparation Example 4 Ogapi Extract

After washing with purified water and drying, 1 kg of powdered ogapi powder was added to 70 ethanol aqueous solution, extracted for 5 days at 15-40 ° C., filtered through 300 mesh filter cloth, left at 4-15 ° C. for 10 days, and then aged at low temperature. It was filtered twice by filter paper. The extract was concentrated under reduced pressure to 70 ° C. in a distillation apparatus equipped with a cooling condenser and dried to obtain 31.4 g (dry weight), and the extraction yield was 3.1 ± 0.3.

Preparation Example 5

Niosomes are mixed in the A phase as a composition of Table 1 to 85 ℃ to uniformly mix, dissolve and cool to 45 ℃ to put the B phase prepared in Preparation Examples 1, 2, 3, 4, and mixed the pressure of 1000 bar It was obtained by passing through a high pressure emulsifier (Microfludizer) three times under the conditions.

Niosomes ingredient A Polyoxyethylene alkyl ether 10.0 Saccharoid ester 20.0 Polyoxyethylene alkyl ester 7.0 Diglycerol 4.0 cholesterol 25.0 Cholesteryl Nonanoate 10.0 Soysterol 15.0 Ceramide 7.0 B Gold 0.5 goldthread 0.5 licorice 0.5 Ogapi 0.5 system 100

Example 1 and Comparative Examples 1 and 2.

Compositions containing niosomes stabilized golden, yellow lotus, licorice, and organ extracts of the present invention (Example 1) and compositions containing no niosomes (Comparative Examples 1 and 2) were prepared.

Unit: weight ingredient Example 1 Comparative Example 1 Comparative Example 2 Delta-tocopherol 0.2 0.2 0.2 Niosome 10.0 - - Golden extract - 0.5 - Huangshan Extract - 0.5 - Licorice Extract - 0.5 - Ogapi Extract - 1.0 - A Cetostearyl alcohol 2.0 2.0 2.0 Glyceryl Stearate 1.5 1.5 1.5 Microcrystallin 0.7 0.7 0.7 Squalane 5.0 5.0 5.0 Liquid paraffin 3.0 3.0 3.0 Trioctanoine 5.0 5.0 5.0 Polysorbate 60 1.2 1.2 1.2 Sorbitan stearate 0.5 0.5 0.5 Cyclomethicone 3.0 3.0 3.0 Tocopheryl Acetate 0.2 0.2 0.2 BHT 0.05 0.05 0.05 B Purified water Remaining amount Remaining amount Remaining amount Concentrated glycerin 4.0 4.0 4.0 1,3-butylene glycol 2.0 2.0 2.0 Santa sword 0.1 0.1 0.1 EDTA-2Na 0.05 0.05 0.05 Incense, preservative Quantity Quantity Quantity system 100 100 100

The niosomes in Table 2 are prepared in Preparation Example 5, and contain golden, yellow lotus, licorice, and ogapi extracts.

Experimental Example 1

The skin elasticity-improving effect of cosmetics containing niosomes stabilized with gold, rhubarb, licorice and organ extract was measured.

1) Experimental method

Thirty healthy women (mean age 29.5 years) over 20 years old were divided into three groups at a temperature of 24 to 26 ° C and a humidity of 75, Example 1 for Group A, Comparative Example 1 for Group B, and Comparative Example 2 for Group C. After formulating according to Table 2, and applied for 12 weeks (2 times / day) around the eyes, the skin elasticity was measured using a skin elasticity measuring instrument (Cutometer SEM 575 C + K Electronic Co., Germany). The test results are described in Table 2 as Cutometer SEM 575 ΔR8 (R8 (12 weeks) -R8 (0 weeks)) values, where R8 values are skin viscoelasticity.

(viscoelasticity) properties. The experimental results are shown in Table 3 below.

2) Experiment result

Skin elasticity (12 weeks) Experimental product Skin elasticity effect Example 1 0.47 Comparative Example 1 0.30 Comparative Example 2 0.08

In the results of Table 3, Example 1 and Comparative Example 1 containing gold, rhubarb, licorice, and organza extracts have an excellent effect on skin elasticity improvement compared to Comparative Example 2, which does not contain golden, rhubarb, licorice, and organza. It can be seen. From this, it can be seen that the four herbal ingredients used in the present invention effectively promote skin elasticity.

In addition, the skin elasticity of Example 1 containing niosomes stabilized golden, yellow lotus, licorice, organ extract, increased 56.7 compared to Comparative Example 1 used directly in the formulation without stabilizing golden, yellow lotus, licorice, organ extract. Therefore, it can be seen that Example 1 containing niosomes stabilized gold, yellow lotus, licorice, and organza extract showed much more excellent effect on skin elasticity.

Experimental Example 2. Moisturizing Effect

The moisturizing effect of the cosmetics containing niosomes stabilized golden, yellow lotus, licorice, and ogapi extract of the present invention was measured.

1) Experimental method

Example 1, Comparative Example 1, and Comparative Example 2, respectively, for 30 healthy women (average age 29.5 years) indoors at 25 ° C., relative humidity 45, and no air flow,

After formulating and applying 3 times 6 weeks around the eyes, TEWAMETER TM210 (C + K electronic GmbH.Germany) was used for transdermal moisture loss, that is, TEWL (Transepidermal Water Loss) value change over time △ TEWL Moisture effect was measured by quantifying the moisture content of the skin from 0 to 150 with the change of the electrical conductivity according to the epidermal moisture content using a CORNEOMETER CM 820 PC (C + K electronic GmbH. Germany). The test results are shown in Table 4 below.

In addition, Example 1 and Comparative Example 1 were formulated according to Table 2, respectively, in order to see the persistence of the moisturizing effect of the present invention, and applied after the first hour, after one hour, TEWAMETER TM210 (C + K electronic GmbH.Germany) The transdermal moisture loss (TEWL) value, ie, the TEWL value change amount ΔTEWL over time, was measured by using the TEM and the electrical conductivity according to the epidermal moisture content using the CORNEOMETER CM 820 PC (C + K electronic GmbH. Germany). Was measured to measure the persistence of the moisturizing effect. The experimental results are shown in Table 4 below.

2) Experiment result

Skin moisturizing effect Experimental product △ TEWL Corneometer value Example 1 5.8 129 Comparative Example 1 3.6 105 Comparative Example 2 0.9 95

Persistence of Moisturizing Effect Experimental product △ TEWL Corneometer value 2hr 4hr 6hr 2hr 4hr 6hr Example 1 12.5 18.2 20.7 135 125 122 Comparative Example 1 18.9 25.6 29.3 121 104 95

As a result, the ΔTEWL value of Example 1 was 5.8 g / hm ² , and the transdermal moisture loss amount was improved 61 ± 4.9 after 6 weeks, compared with Comparative Example 1, showing a very good improvement effect.

In addition, in the Corneometer Value measuring the moisture content of the skin, Example 1 increased by 22.9 and 40.2, respectively, compared to Comparative Example 1 and Comparative Example 2, it can be seen that the skin is very moist.

Also in the persistence for the moisturizing effect of Example 1 containing the niobium of the present invention, the amount of moisture is rapidly increased over time, so that the skin is moisturized for a long time. Smaller particle size makes it easier to penetrate the skin, increasing the persistence of the moisturizing effect.

Experimental Example 3. Skin Penetration Effect

The skin penetrating effect of the cosmetics containing niosomes stabilized the golden, sulfur, licorice, and ogapi extract of the present invention was measured.

1) Experimental method

Dermal Equivalent (DE) -Human normal fibroblast 1 × 10 ⁵ cells / ml Collagen aqueous solution 3 mg / ml: 5X DMEM: 2.2 sodium bicarbonate in a collagen gel structure similar to the fibrous tissue of human connective tissue (Sodium bicarbonate) and 0.05N sodium hydroxide containing 200mM Hepes buffer inoculated in a medium mixed with 7: 2: 1 and cultured at 5O ² , 37 ° C for 7 days-3㎛ porous polycarbonate material Epidermal Keratinocyte 1X10 ⁵ cells / ml cells were placed on the inside of the plates separated by the inner membrane and the outer surface of Dermal Equivalent (DE) where the fibroblasts were cultured. After inoculation, EGF and BPE-containing K-SFM medium was put into the inside and the outside and incubated for 7 days. Afterwards, the medium inside the plate was discarded to allow the air to come into contact with the surface of the cultured cells, followed by culturing for 2 weeks in a medium mixed with the same amount of K-SFM containing 10FBS and DMEM without EGF. Artificial skin with dermis was obtained. Experimental Example 1 and Comparative Example 1 of the present invention were applied to the artificial skin tissue of the upper layer, followed by 4 hours of incubation, and then the artificial skin of the medium was mixed in the same amount of K-SFM containing 10FBS and DMEM without EGF. The amount of extract passed through the epidermis and dermis was analyzed by HPLC. The experimental results are shown in Table 6 below.

2) Experiment result

Skin penetration result Amount of extract in medium (µg / 1ml) Experimental Example Comparative Example 1 Gold 620 35 goldthread 522 48 licorice 710 83 Ogapi 1230 74

As shown in the results of Table 6, Example 1 containing the niosomes stabilized golden, yellow lotus, licorice, Ogai extract penetrated about 10 to 20 times compared to Comparative Example 1 using the golden, yellow lotus, licorice, Ogai extract as it is It can be seen that the effect is excellent. This further facilitated skin penetration by making the diglycerin used as an auxiliary emulsifier in the niosomes of the present invention very small, with an average particle size of niosomes of 100 nm.

Experimental Example 4. Stability Test of Formulation

The stability of the formulations for the cosmetics containing niosomes stabilized the golden, yellow lotus, licorice, organ extract of the present invention was measured.

1) Experimental method

In order to test the stability of the cosmetics Example 1, Comparative Examples 1 and 2 in a opaque glass container kept in a constant temperature maintained at 45 ℃ constant storage for 12 weeks in a completely shaded refrigerator kept at 4 ℃ After storing for 12 weeks in an opaque pendulum container, the degree of separation and discoloration were measured. The results are shown in Table 7 below. At this time, product separation and discoloration were evaluated by classifying into the following six grades.

Product discoloration evaluation criteria:

0: No change 1: Very little separation (discoloration)

2: Slightly separated (discolored) 3: Slightly separated (discolored)

4: Extremely separated (discolored) 5: Extremely separated (discolored)

Separation and discoloration Temperature Discoloration degree of test substance Example 1 Comparative Example 1 Comparative Example 2 45 ℃ 0 3.0 0 4 ℃ 0 0 0

As can be seen in Table 7, Example 1 and Comparative Example 2 was stable at 45 ℃ without discoloration or separation symptoms, Comparative Example 1 used directly in the formulation without stabilizing the gold, yellow lotus, licorice, Ogai extract of the present invention It can be seen that the extract became unstable due to a slight discoloration at 45 ° C.

Hereinafter, based on the results of the above experimental examples, to present a cosmetic composition containing niosomes stabilized gold, yellow lotus, licorice, Ogapi extract of the present invention. However, the composition of the present invention is not intended to be limited to the following formulation examples.

Formulation Example 1 Softening Cosmetic (Skin Lotion)

As shown in the following table, the softening lotion was prepared according to a conventional method.

Ingredient Parts by weight Niosome 1.0 1,3-butylene glycol 6.0 glycerin 4.0 Oleyl alcohol 0.1 Polysorbate 20 0.5 ethanol 15.0 Benzophenone-9 0.05 Incense, preservative a very small amount Purified water to 100

Formulation Example 2. Nutrients (Milk Lotion)

Nutrients were prepared according to a conventional method as shown in the following table.

Ingredient Parts by weight Niosome 3.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 1.2 Tocopheryl Acetate 3.0 Floating paraffin 5.0 Squalane 3.0 Macadamia Nut Oil 2.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.0 Carboxy Vinyl Polymer 1.0 BH 0.01 IDT-2N 0.01 Incense, preservative a very small amount Purified water to 100

Formulation Example 3. Nutrition Cream

Nutritious cream was prepared according to a conventional method as shown in the following table.

Ingredient Parts by weight Niosome 10.0 Cetostearyl alcohol 2.0 Glyceryl Stearate 1.5 Octano-in 5.0 Polysorbate 60 1.2 Sorbitan stearate 0.5 Squalane 5.0 Liquid paraffin 3.0 Cyclomethicone 3.0 BH 0.05 Delta-tocopherol 0.2 Concentrated glycerin 4.0 1,3-butylene glycol 2.0 Xanthan Gum 0.1 IDT-2N 0.05 Incense, preservative a very small amount Purified water to 100

Formulation Example 4 Massage Cream

Massage creams were prepared according to conventional methods as shown in the following table.

Ingredient Parts by weight Niosome 1.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Beeswax 2.0 Tocopheryl Acetate 0.1 Polysorbate 60 3.0 Sorbitan sesquioleate 2.5 Cetearyl Alcohol 2.0 Liquid paraffin 30.0 Carboxy Vinyl Polymer 0.5 Incense, preservative a very small amount Purified water to 100

Formulation Example 5 Pack

Packs were prepared according to conventional methods as shown in the table below.

Ingredient Parts by weight Niosome 2.0 Propylene glycol 2.0 glycerin 4.0 Carboxy Vinyl Polymer 0.3 ethanol 7.0 Fiji-40 Hydrogenated Castor Oil 0.8 Triethanolamine 0.3 BH 0.01 IDT-2N 0.01 Incense, preservative a very small amount Purified water to 100

The present invention effectively stabilizes the golden, yellow lotus, licorice, and ogapi extracts of the present invention in the closed double layer structure by completing the blocked double layer structure, thereby increasing skin elasticity and moisturizing effect by increasing penetration into the skin. To maximize the effect of the active ingredient.

Claims (14)

Niosome-containing cosmetic composition stabilized with golden, yellow lotus, licorice and organ extract The cosmetic composition according to claim 1, wherein the cosmetic composition comprises 0.1 to 10 weight of gold, rhubarb, licorice, and ogapi extract based on the total weight of niosomes. The cosmetic composition according to claim 1, wherein the golden extract is contained in an amount of 0.001 to 3.0 weight of the total weight of niosomes. The cosmetic composition according to claim 1, wherein the rhubarb extract is contained in an amount of 0.001 to 3.0 weight of the total weight of niosomes. The cosmetic composition according to claim 1, wherein the licorice extract is contained in an amount of 0.001 to 3.0 weight of the total weight of niosomes. The cosmetic composition according to claim 1, wherein the extract is contained in an amount of 0.001 to 5.0 weight of the total weight of niosomes. The mixture of claim 1, wherein the niosome comprises a mixture of 10-50 weight nonionic surfactant, 1-50 weight co-emulsifier, 30-80 weight cholesterol, cholesteryl ester and soysterol relative to the total weight of niosome. Cosmetic composition containing 8. The cosmetic composition according to claim 7, wherein the nonionic surfactant is selected from polyoxyethylene alkyl ethers, polyoxyethylene alkyl esters, and saccharoids. The cosmetic composition according to claim 7, wherein the co-emulsifier is diglycerol. The cosmetic composition according to claim 7, wherein the cholesteryl ester is selected from cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, and cholesteryl isostearyl carbonate. The cosmetic composition according to claim 7, further comprising ceramide. The cosmetic composition according to claim 11, wherein the ceramide is contained in an amount of 0.1 to 10 weight based on the total weight of niosomes. The method of claim 7, wherein the niosomes are mixed and dissolved nonionic surfactant, co-emulsifier, cholesterol (Cholesterol), cholesteryl ester and Soy sterol A cosmetic composition characterized in that the cooling, and completed by mixing high-pressure emulsification of golden, yellow lotus, licorice, organ extract The cosmetic composition according to claim 1, wherein the formulation is a softening cream, astringent makeup, nutrition cream, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, essence, pack.