CN110302121A - A kind of baby's diaper ointment and preparation method thereof containing plant essence - Google Patents
A kind of baby's diaper ointment and preparation method thereof containing plant essence Download PDFInfo
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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Abstract
The invention discloses a kind of baby's diaper ointments and preparation method thereof for containing plant essence, component including following mass fraction: 60~90 parts of vaseline, 5~15 parts of atoleine, 2~10 parts of microwax, 2~10 parts of camellia seed oil, 3~8 parts of zinc oxide, 0.1~1 part of antioxidant, 0.1~1 part of bisabolol, 1~5 part of evening primrose oil, 0.01~1 part of olea europaea fruit extract, 0.01~1 part of water；Antioxidant is tocopherol acetate, contains olive polyphenol substance in olea europaea fruit extract, especially includes hydroxytyrosol.The present invention is applied to camellia seed oil, evening primrose oil, olea europaea fruit extract in product using modern extraction technique, using the hydrophobic function of grease, reaches the isolation to baby's excreta, skin is avoided to be stimulated；There is anti-inflammatory, antibacterial, antipruritic and distinctive anti-ammonia stimulation simultaneously, skin is allowed to reply comfort conditions.
Description
Technical field
The present invention relates to skin care field more particularly to a kind of baby's diaper ointment for containing plant essence and its preparation sides
Method.
Background technique
As paper diaper are widely used in the market, infant hip is often because contacting its excreta (including urine and excrement
Just irritative response) is generated, baby child's skin of buttock itch, allergic dermatitis, eczema etc. is caused, causes newborn diapers skin
It is red to be commonly called as stern for inflammation.Its reason is that infant skin is thinner tender, and sweat gland and sebaceous glands development are not yet mature, and sebum secretion is few, causes
Its is vulnerable, is easier to be absorbed and enter skin with the substance of skin contact, is easy to be infected by bacterial, become to ambient temperature
It is sensitive to change reaction, Yi Yinqi allergy, redness, erythema, the skin problems such as bubble.Now common way be using talcum powder, but
Talcum powder contains the inorganic particles such as talcum powder, is easy blocking pore, causes health problem by human body sucking etc..And it is existing on the market
Baby child's diaper ointment kind it is seldom, it is general only have form protective film in skin surface, avoid the urine and stool of discharge, directly stimulation flesh
The effect of skin cannot persistently keep being isolated, and can not effectively be alleviated to the red inflammation of the stern occurred or therapeutic effect.
Mother and baby market is increasing to diaper ointment demand.
Summary of the invention
The purpose of the present invention is overcoming the above-mentioned prior art, provide it is a kind of safe and non-stimulating and can play persistently every
From, effectively nourish, a kind of baby's diaper ointment for containing plant essence and preparation method thereof with the treatment red inflammation of stern be effectively relieved.
The present invention is achieved through the following technical solutions:
A kind of baby's diaper ointment containing plant essence, including following components in parts by mass: 60~90 parts of vaseline, liquid
5~15 parts of body paraffin, 3~8 parts of zinc oxide, 2~10 parts of microwax, 2~10 parts of camellia seed oil, 1~5 part of evening primrose oil, antioxygen
0.1~1 part of agent, 0.1~1 part of bisabolol, 0.01~1 part of olea europaea fruit extract, 0.01~1 part of water.
Preferably, the antioxidant is tocopherol acetate.Camellia seed oil, evening primrose oil etc. contain unsaturated fat
Acid, easy to oxidize and rotten, antioxidant can make product with stable quality, stablize storage, while be efficiently nonirritant antioxygen
Agent is suitble to infant's skin.Antioxidant is further selected from vine polyphenol, co-ferment Q10, tea polyphenols etc..
Preferably, a kind of baby's diaper ointment containing plant essence, including following components in parts by mass: vaseline 60~
80 parts, 5~15 parts of atoleine, 3~8 parts of microwax, 3~8 parts of camellia seed oil, 3~8 parts of zinc oxide, tocopherol acetate 0.5
~1 part, 0.1~0.5 part of bisabolol, 1~5 part of evening primrose oil, 0.1~1 part of olea europaea fruit extract, 0.1~1 part of water.
Evening primrose oil is a kind of grease rich in a variety of unsaturated fatty acids, and unsaturated fatty acid accounts for 91.2%, wherein containing
There are 70% or more linoleic acid and 9% or so gamma-Linolenic acid, is that other greases are more rare, it can be straight on nutraceutical
It connects and is used as nutrition oil, nutrient blend oil, can also be added in other food and produce functional dietetic food.Wherein γ-flax
Acid is that a kind of human body itself cannot synthesize and the highly unsaturated fatty acid with important physiological activity, it is a kind of important battalion
Substance is supported, the final product being metabolized in vivo has significant antithrombotic, anti-inflammatory, inhibition growth of cancer cells, reduction blood
The curative effects such as clearing gallbladder sterol, treatment atherosclerosis.It can cause skin metabolism disorder when if lacking, fash occurs.Also there is research
It will be used for skin surface outside evening primrose oil, the cell metabolism of skin and the secretion of sebaceous glands is adjusted, brings elasticity of skin, and promote
Make regenerated function.Oenothera biennis is used for skin-protection product, it is non-stimulated to skin, skin sense is good, stability is strong, it can especially mend
Skin supplement ingredient is filled, and promotes skin metabolism regeneration；With in aromatherapy, evening primrose oil can reconcile lotion, creams, change
Kind eczema, psoriasis, help wound healing.
Bisabolol has anti-inflammatory anti-inflammatory, anti-bacterial, anti-itching, alleviating pain and detumescence, the pharmacology for promoting cytothesis and wound healing
Effect.
Zinc oxide has anti-inflammatory, drying, absorption, convergent effect, and property is mildly non-stimulated, has protection skin, reduces
The effect of rubbing and preventing external irritant.Clinical medicine shows, no any secondary work quick with zinc oxide treatment infantile eczema
With, and difficulty in relapse after healing is controlled, cost performance is high.
Camellia seed oil is extracted from woody oily section plant " camellia oleifera fruit ", is the big famous xylophyta oil in the world four
One and International Health Organization generally acknowledge most healthy vegetable oil, camellia seed oil contains 90% unsaturated fatty acid, with oleic acid and Asia
Based on oleic acid, thus there is good skin sense, salubrious non-greasy, absorb fast, moistness is good, the brightness for smearing position can be increased and
It is honorable.Ancient literature " agricultural administration book " " detailed outline is picked up any lost article from the road " record tea-seed oil can ease constipation clearing stomach, disinfecting detoxifying, clearing liver fall fire, accelerate
Wound healing and other effects.
Preferably, olive polyphenol substance is contained in the olea europaea fruit extract.
Preferably, the olive polyphenol substance includes hydroxytyrosol.
Olive has a variety of biologies such as enhancing health of heart, anticancer, antibacterial, anti-inflammatory and pharmacological activity, modern biotechnology skill
Art analysis shows, in olive active material mainly have olive polyphenol, flavonoids, driffractive ring alkene ether mushroom class (including olive hardship is general),
Biflavone etc., and much testing all proves that olive polyphenol extract has stronger free radical scavenging ability and higher anti-oxidant
Activity.The inoxidizability of olive polyphenol is a kind of comprehensive effect, and inoxidizability is mainly derived from a large amount of hydroxyl in polyphenol molecule
Base tyrosol, there are two phenolic hydroxyl groups on hydroxytyrosol molecule, are a kind of to have phenolic hydroxyl group characteristic in addition, there are one alcoholic extract hydroxyl group
Amphiphatic molecule with alcoholic extract hydroxyl group characteristic can be by controlling many unsaturated fatty acids with very strong antioxidation
Oxidation, can effectively remove exogenous and Endogenous oxidative object and free radical.Containing olive polyphenol, (hydroxytyrosol is generation simultaneously
Table) ingredient olive extract, also there is powerful and unique anti-inflammatory analgetic, antibacterial, antiviral and other effects, can be effectively relieved each
Kind skin disease such as eczema, psoriasis, allergic dermatitis problem；And have good inhibiting effect to enzyme, it can be by remaining strong
The metabolism of blood glucose of health promotes skin metabolism, promotes wound healing, effectively enhancing skin elasticity.
More importantly olea europaea fruit extract has distinctive anti-ammonia stimulation, test is proved, dense 0.5%
Under degree, is inducing stimulation to generate 2 days, 3 days, 7 days of erythema with ammonia, be in than general antianaphylaxis components with olea europaea fruit extract
Now better effect.
A kind of a kind of preparation method of baby's diaper ointment for containing plant essence, comprising the following steps:
A mine ester, atoleine, microwax) are weighed, is added in production cylinder, heats while stirring to dissolution；
B after) being cooled to 60~70 DEG C, camellia seed oil, zinc oxide, tocopherol acetate or vitamin E, opopanax are added
Alcohol, evening primrose oil, stir evenly, and continue to be cooled to 40~45 DEG C；
C) by water, olea europaea fruit extract after stirring and dissolving is uniform in clean container, above-mentioned steps B is added) in life
It produces in cylinder, stirs evenly, discharge after the assay was approved.
The main reason for baby's stern is red is that paper diaper can not be replaced frequently in time, and wind wind is sultry, moist, airtight,
Baby's wind wind can be stimulated when having urine and impregnating too long, moist wind wind is easy to be encroached on, and diaper long-time and wind wind
Friction, causes rubescent.
The present invention is to be formed protective film on skin surface using inertia grease, reached the isolation to baby's excreta, kept away
Exempt from skin to be stimulated, mitigates friction of the paper diaper to skin；In combination with traditional herbal ancient prescription, using modern extraction technique
Camellia seed oil, evening primrose oil, olea europaea fruit extract are applied in product, construct natural protect using natural oil active constituent
Barrier is protected, skin barrier function is promoted, skin is persistently effectively moistened, season cracking is prevented；Simultaneously have anti-inflammatory, antibacterial,
Antipruritic and distinctive anti-ammonia stimulation, allows skin to reply comfort conditions.In addition product contains zinc oxide, has antibacterial anti-inflammatory, convergence
And the repair to skin.
Active ingredient of natural plant used in formula of the invention is that safely and effectively substance is suitble to mildly without hormone
Baby uses, and especially evening primrose oil is a kind of pole safely and effectively nutrients, is easy to be absorbed by the skin after use, and have work
Blood, it is anti-inflammatory, antifreeze the effects of；It is with strong points, infant's development is aimed at, multiple dimensions solve the rubescent of baby's hip, itch etc.
Symptom prevents infant hip erythema, inflammation；Plurality of active ingredients synergistic effect, improvement effect, while certain prices can be reduced
The dosage of high component, reduces cost；Product quality Shu Run, tends to smear out；It is easy to use, it takes in right amount, is softly uniformly applied to
Cleaning and dry and comfortable baby buttocks.
Specific embodiment
A kind of baby's diaper ointment constituent and its use containing plant essence described in the embodiment of the present invention 1~4
Amount is as shown in table 1 below:
A kind of baby's diaper ointment compositing formula (unit: part) of antibacterial maintenance described in 1 Examples 1 to 4 of table
| Component | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| Vaseline | 66 | 73.9 | 77.3 | 60 |
| Atoleine | 10 | 8 | 5 | 14.1 |
| Microwax | 6 | 5 | 3 | 8 |
| Camellia seed oil | 8 | 3 | 5 | 6 |
| Zinc oxide | 6 | 5 | 4 | 7 |
| Bisabolol | 0.3 | 0.2 | 0.3 | 0.2 |
| Evening primrose oil | 2 | 4 | 4 | 3 |
| Olea europaea fruit extract | 0.4 | 0.1 | 0.2 | 0.3 |
| Tocopherol acetate | 0.5 | 0.6 | 0.8 | 0.8 |
| Water | 0.8 | 0.2 | 0.4 | 0.6 |
The olea europaea fruit extract (is criticized purchased from hundred Hao Bo Co., Ltd of Guangzhou or Guangzhou Nuo Ran Biotechnology Co., Ltd
Number 19052113), it can also be the similar product of other producers；Zinc oxide is purchased from Merck KGaA company, and vitamin E is purchased from Bath
Husband company, evening primrose oil are purchased from Guangzhou Lan Yu trade Co., Ltd.
A kind of preparation method of baby's diaper ointment containing plant essence described in the described one kind of the embodiment of the present invention 1~4,
The following steps are included:
(1) mine ester, atoleine, microwax are weighed, is added in production cylinder, heats while stirring to dissolution；
(2) it after being cooled to 60~70 DEG C, adds and sees camellia seed oil, zinc oxide, tocopherol acetate, bisabolol, the moon
Careless oil, stirs evenly, continues to be cooled to 40~45 DEG C；
(3) it by water, olea europaea fruit extract after stirring and dissolving is uniform in clean container, is added in above-mentioned steps (2)
It produces in cylinder, stirs evenly, discharge after the assay was approved.
The basic condition of control group 1~9 is shown in Table 2.
The basic condition of 2 control group of table, 1~9 product
| Manufacturer | Product characteristics | |
| Control group 1 | Japanese brand | Pure oil type |
| Control group 2 | American blend | W/o type |
| Control group 3 | Britain's brand | O/W type |
| Control group 4 | Denmark's brand | O/W type |
| Control group 5 | American blend | W/o type |
| Control group 6 | Home brands | O/W type |
| Control group 7 | Britain's brand | W/o type |
| Control group 8 | Home brands | Pure oil type |
| Control group 9 | German brand | W/o type |
Performance test:
1. basic index is tested
Product manufactured in the present embodiment is w/o type, milky paste.It is surveyed according to the standard of QB/T 1857-2013
Examination, test result are shown in Table 3.
The product basic index of 3 Examples 1 to 4 of table
2. isolation effect test method
Test and determination method: hip pad product (0.4g is just paved with filter paper) is smeared in 1/4 surface, is added dropwise
Whether 0.85% physiological saline 0.4g, different time observation filter paper can form protective film isolation physiological saline, apply stern protection cream
Whether filter paper is wetted.If filter paper is not wet and the apparent droplet of particle is presented, it was demonstrated that urine effect is isolated in hip pad product
Fruit is outstanding；If filter paper soaks, not formed droplet, then hip pad product isolation urine effect is poor；Evaluation result is point poor, general, good,
Outstanding four grades.
Test result is shown in Table 4.
The isolation effect of 4 Examples 1 to 4 of table and control group 1~9
3. waterproof effect is tested
Under same temperature and humidity conditions, 0.05mg hip pad product is taken uniformly to be applied to the hand in tester (no less than 5)
The square area of 3.0cmx3.0cm on the inside of arm, then it is paved with distilled water in the area until not flowing down just with dropper,
Stablize after five minutes with after paper handkerchief suck dry moisture, tests the moisture content of the area skin, water with moisture of skin instrument measuring instrument immediately
The then waterproof effect for dividing content high is poor, the relatively low then good water-proof effect of moisture content.Test result is shown in Table 5.
The waterproof effect (25 DEG C of temperature, relative humidity 50%) of 5 Examples 1 to 4 of table and control group 1~9
| Skin moisture content (%) | |
| Embodiment 1 | 43.7 |
| Embodiment 2 | 44.6 |
| Embodiment 3 | 45.5 |
| Embodiment 4 | 43.9 |
| Control group 1 | 45.2 |
| Control group 2 | 48.6 |
| Control group 3 | 68.3 |
| Control group 4 | 68.5 |
| Control group 5 | 50.3 |
| Control group 6 | 65.6 |
| Control group 7 | 53.3 |
| Control group 8 | 44.3 |
| Control group 9 | 56.7 |
The superiority and inferiority of waterproof effect be respectively as follows: 1 > embodiment of embodiment 1 > embodiment, 4 > control group, 8 > embodiment, 2 > control group 3 >
6 ≈ control group of control group 2 > control group, 5 > control group, 7 > control group, 9 > control group, 4 ≈ control group 3.
4.W/O system smears light and thin degree
The present embodiment product is W/O system, to even things up, specifically for the embodiment and control group of W/O system, test
It smears light and thin degree.Using the method for tester's sensory evaluation, take 0.05mg hip pad product be uniformly applied to tester (no
Less than 5) inboard arm 3.0cmx3.0cm square area, the weight bearing sense of its skin of sensory evaluation, 1~10 point marking,
10 points very frivolous for dermal sensation, and no greasy burden sense takes the average value of tester.Test result is shown in Table 6.
The smearing light and thin degree of table 6W/O system implementation example and control group
| Score | |
| Embodiment 1 | 7.8 |
| Embodiment 2 | 8.0 |
| Embodiment 3 | 7.5 |
| Embodiment 4 | 8.5 |
| Control group 2 | 8.3 |
| Control group 5 | 5.5 |
| Control group 7 | 6.8 |
| Control group 9 | 7.5 |
By table 6 as it can be seen that smear light and thin degree order of quality be respectively as follows: 2 > embodiment of embodiment 4 > control group, 2 > embodiment 1 >
7 > control group of embodiment 3=9 > control group of control group 5.
5.W/O system smear
Ibid, the embodiment of W/O system and the smear of control group are tested, i.e., whether easily can uniformly push paste production open
Product.Tester voluntarily provokes product with finger, is applied on skin according to each one use habit, sense organ comparison marking, 1~
10 points of marking, 10 points are uniformly pushed open the average value for taking tester on the skin to be very easy.Test result is shown in Table 7.
The smear of table 7W/O system implementation example and control group
By table 7 as it can be seen that the order of quality of smear is respectively as follows: embodiment 1 > embodiment, 4 > embodiment 2=control group 2 > reality
Apply 7 > control group of example 3 > control group, 5 > control group 9.
6. clinical trial
Product of the present invention is sent to the clinical assessment of three Li Huiping cosmetics Science and Technology Ltd. of Beijing progress for 40 bottles totally.
Test purpose: improvement of the evaluation test sample to the red phenomenon of baby's stern；
Number of subjects: 30 people；
Subject's gender: 13 people of female, male 17 people；
Subject age: 0~2 years old；
Test zone: buttocks flush region；
Test period: 5 days；
Skin color test (Chromameter): using skin spectral photometric colour measuring meter Chromameter (CM-700D,
Konica Minolta, Japan) test skin color.It is characterized using Lab colorimeter system as defined in International Commission on Illumination (CIE)
Skin color.Wherein, L*For brightness, a*For red green degree, b*Overall merit for blue yellow chromaticity, three is able to reflect skin-color
The variation of degree, a*It can reflect the redness of skin, a*Show that skin is redder more greatly.A is used in this test*As evaluation buttocks
The parameter of redness.
Dermal imaging tests (Tivi): skin sensitivity tester Tivi (Wheels Bridge, Sweden) and utilizes red blood cell
To the absorption characteristic of green light, quantitative analysis is carried out to the concentration of red blood cell, image is generated according to analysis test result, is used in image
The susceptibility of color expression skin.Color of image indicates that rubefaction is more serious closer to the right side of coloration ruler.
Product of the present invention is by continuous 5 days normal individual trials (having 2 subjects to exit test) during test, before using
Comparison, for evaluation test sample to the improvement of the red phenomenon of baby's stern, concrete condition is as follows:
Totally 30 subjects take one's test, and use sample, continuous use 5 in subject's stern red area daily during test
It, (initial value), sample carry out skin color test, skin to test zone using after 1 day, 3 days and 5 days before sample use
Skin color parameter a*Test result is shown in Table 8.
Before 8 use of table, using after 1 day, skin color a after 3 days and after 5 days*Average value and statistical result
The improvement degree of the red phenomenon of stern is assessed according to buttocks imaging Tivi picture by doctor, is shown, is surveyed with score value
Test result is shown in Table 9, and average mark is higher, and improvement is more obvious.
9 sample of table use 1 day after, skin condition improves demographics (n=28) after 3 days and after 5 days
From the above results, skin color test result is shown, before use compared with, after 1 day, 3 days and 5 days,
Skin color parameter a*Value significantly reduces (P < 0.05), and reduced rate is followed successively by 10.9%, 17.7% and 23.2%.
Doctor's assessment result shows, before use compared with, after 1 day, 3 days and 5 days, the red phenomenon of stern gradually improves, and
Statistically there is conspicuousness to change (P < 0.05).
In summary analyze, within 5 days test periods, before use compared with, baby's diaper ointment shows to improve baby
The effect of the red phenomenon of stern.
Above-listed detailed description is illustrating for possible embodiments of the present invention, and the embodiment is not to limit this hair
Bright the scope of the patents, all equivalence enforcements or change without departing from carried out by the present invention, is intended to be limited solely by the scope of the patents of this case.
Claims (6)
1. a kind of baby's diaper ointment for containing plant essence, which is characterized in that including following components in parts by mass: vaseline 60
~90 parts, 5~15 parts of atoleine, 3~8 parts of zinc oxide, 2~10 parts of microwax, 2~10 parts of camellia seed oil, evening primrose oil 1~
5 parts, 0.1~1 part of antioxidant, 0.1~1 part of bisabolol, 0.01~1 part of olea europaea fruit extract, 0.01~1 part of water.
2. a kind of baby's diaper ointment for containing plant essence according to claim 1, which is characterized in that the antioxidant
For tocopherol acetate.
3. a kind of baby's diaper ointment for containing plant essence according to claim 2, which is characterized in that including pressing mass parts
The following components of meter: 60~80 parts of vaseline, 5~15 parts of atoleine, 3~8 parts of zinc oxide, 3~8 parts of microwax, camellia seed oil 3
~8 parts, 1~5 part of evening primrose oil, 0.5~1 part of tocopherol acetate, 0.1~0.5 part of bisabolol, olea europaea fruit extract
0.1~1 part, 0.1~1 part of water.
4. a kind of baby's diaper ointment for containing plant essence according to claim 1, which is characterized in that the olea europaea fruit
Contain olive polyphenol substance in extract.
5. a kind of baby's diaper ointment for containing plant essence according to claim 4, which is characterized in that the olive polyphenol
Substance includes hydroxytyrosol.
6. a kind of a kind of preparation method of baby's diaper ointment for containing plant essence as described in claim 2~5, feature exist
In, comprising the following steps:
A mine ester, atoleine, microwax) are weighed, is added in production cylinder, heats while stirring to dissolution；
B after) being cooled to 60~70 DEG C, camellia seed oil, zinc oxide, antioxidant, bisabolol, evening primrose oil are added, is stirred
Uniformly, continue to be cooled to 40~45 DEG C；
C) by water, olea europaea fruit extract after stirring and dissolving is uniform in clean container, above-mentioned steps B is added) in production cylinder
In, it stirs evenly, discharges after the assay was approved.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111557867A (en) * | 2020-04-21 | 2020-08-21 | 上海纽因贝母婴用品有限公司 | Infant soothing cream and preparation method thereof |
| CN112402273A (en) * | 2020-12-01 | 2021-02-26 | 金发拉比妇婴童用品股份有限公司 | Cream for improving red buttocks of infants and preparation method thereof |
| CN112402273B (en) * | 2020-12-01 | 2023-10-03 | 金发拉比妇婴童用品股份有限公司 | Cream for improving red buttocks of infants and preparation method of cream |
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