CN112402273A - Cream for improving red buttocks of infants and preparation method thereof - Google Patents

Abstract

The invention discloses cream for improving red buttocks of infants and a preparation method thereof, and belongs to the technical field of infant skin care products. According to the cream for improving the red butt of the infants, the moisturizer, the anti-irritant agent, the enzyme activity inhibitor, the colloidal sulfur, the squalane, the calamine and the zinc oxide are reasonably compounded, so that the problem of the red butt of the infants can be solved from multiple aspects, and the cream has excellent effects on prevention and repair of the red butt of the infants; and oil easy to wash by water is selected as base oil, so that the obtained cream is easy to wash and wipe by water, and discomfort of skin stuffiness after use can be avoided.

Description

Cream for improving red buttocks of infants and preparation method thereof

Technical Field

The invention belongs to the technical field of infant skin care products, and relates to cream for improving red buttocks of infants and a preparation method thereof.

Background

Generally, most infants develop a red buttock, broken skin and ulceration. According to the analysis of related data, the red fart of the infant has the following reasons: the first reason is that when the baby uses the paper diaper or the diaper, the excrement such as the self-body excrement, urine and sweat can directly stimulate the hip skin; the second reason is the infection of the skin of the infant's buttocks by bacteria in excrement such as feces and urine; the third reason is the corrosion of the hip skin caused by excrement residue such as feces and urine, protease secreted by bacteria, urease, insulinase and other substances; moreover, the breathing of the hip skin is not smooth when the infant wears the paper diaper and other airtight products for a long time.

Most products in the market rely on the sterilization and convergence of zinc oxide; urine and excrement are isolated by using the water isolation effect of the paste, but the technical problem that the red buttocks of infants are generated is difficult to solve by only adopting a sterilization and isolation method in the conventional scheme.

Disclosure of Invention

In order to overcome the defects and shortcomings in the prior art, the invention aims to provide cream for improving red buttocks of infants and a preparation method thereof.

In a first aspect, the invention provides a cream for improving red buttocks of infants, which is mainly prepared from the following raw materials in percentage by weight: 5-30% of humectant, 0.5-10% of anti-irritant agent, 0.5-10% of enzyme activity inhibitor, 1-10% of colloidal sulfur, 25-80% of squalane, 1-50% of base oil, 0.1-2% of emulsifier, 1-5% of calamine and 5-20% of zinc oxide.

In the cream, the humectant plays a role in moistening; the anti-irritant agent can enhance the anti-irritation of the skin; the enzyme activity inhibitor can inhibit the activity of protease, urease, insulinase, etc., and reduce the corrosivity of these enzymes to skin; after the colloidal sulfur contacts the skin, the colloidal sulfur reacts with skin secretions to generate sulfides such as hydrogen sulfide, pentacolloidal sulfuric acid and the like, and the sulfides have the effects of inhibiting sebum secretion, killing bacteria, fungi, molds, mites, parasites and the like, so that the phenomenon of red buttocks is relieved; the squalane can play a role in isolating urine and excrement and has a moisturizing effect; calamina and zinc oxide have antibacterial and astringent effects. The cream can solve the problem of red wind of infants from multiple aspects by reasonably compounding the humectant, the anti-irritant agent, the enzyme activity inhibitor, the colloidal sulfur, the squalane, the calamine and the zinc oxide, and has excellent effects on prevention and repair of the red wind of infants. The cream is easy to wash and wipe when meeting water, and can avoid the discomfort of skin stuffiness after use.

As a preferred embodiment of the cream, the cream raw materials further comprise the following components in percentage by weight: 0.01-0.5% hexamidine di (isethionic acid) salt. The hexamidine di (isethionic acid) salt is added, so that the sterilization effect can be further enhanced, and the improvement effect of the cream on the red buttocks of infants is improved.

As a preferred embodiment of the cream of the present invention, the moisturizer comprises glycerin. The humectant can be selected from butanediol, glycerol, etc., preferably glycerol.

As a preferred embodiment of the cream of the present invention, the anti-irritant comprises PERILLA (PERILLA octodes) leaf extract. The folium Perillae extract can not only enhance skin irritation resistance, but also enhance skin blood circulation, thereby improving skin respiration efficiency.

As a preferred embodiment of the cream of the present invention, the enzyme activity inhibitor comprises evening primrose (Oenothera BIENNIS) oil. The evening primrose oil can well inhibit the activities of protease, urease and trypsin.

As a preferred embodiment of the cream of the present invention, the emulsifier is a cationic emulsifier. The cationic emulsifier not only has emulsification effect, but also has sterilization effect.

As a preferred embodiment of the cream of the invention, the cationic emulsifier is palmitoylamidopropyltrimethylammonium chloride.

As a preferred embodiment of the cream of the present invention, the cream is free of water. The cream can be made of water-free raw materials or the water in the cream can be removed by heating and the like, so that the problems of microbial pollution of products and microbial cross infection on skin can be effectively avoided.

In a second aspect, the invention further provides a preparation method of the above modifying paste, which comprises the following steps:

(1) mixing enzyme activity inhibitor, squalane, calamine and zinc oxide, ball-milling, filtering to uniformly disperse solid in liquid, and heating to 70-85 ℃ to obtain a first mixture;

(2) mixing the rest raw materials except the colloidal sulfur and the basic grease, heating to 60-95 ℃, stirring to completely dissolve the solid, and keeping the temperature open to completely volatilize the water to obtain a second mixture;

(3) adding the first mixture into the second mixture while stirring, and then homogenizing to obtain a third mixture;

(4) and cooling the third mixture while stirring, cooling to below 45 ℃, adding colloidal sulfur, uniformly stirring, cooling to below 40 ℃, adding base oil, and uniformly stirring to obtain the cream.

Compared with the prior art, the invention has the following advantages: according to the invention, the humectant, the anti-irritant agent, the enzyme activity inhibitor, the colloidal sulfur, the squalane, the calamine and the zinc oxide are reasonably compounded, so that the problem of red butt of infants can be synergistically solved from multiple aspects, and the prevention and repair effects of the product on the red butt are improved; meanwhile, the mask is easy to wash and wipe when meeting water, so that the discomfort of skin stuffiness after use can be avoided.

Detailed Description

To better illustrate the objects, aspects and advantages of the present invention, the present invention is further illustrated by the following examples. It is apparent that the following examples are only a part of the embodiments of the present invention, and not all of them. It should be understood that the embodiments of the present invention are only for illustrating the technical effects of the present invention, and are not intended to limit the scope of the present invention.

Examples 1 to 7

Examples 1-7 are all one embodiment of the cream for improving red buttocks of infants. Examples 1-7 the raw material composition of a cream for improving the red buttocks of infants is shown in table 1.

Table 1 examples 1-7 raw material composition/wt% of cream for improving red buttocks of infants

Examples 1-7 methods of preparing creams for improving red buttocks of infants and young children, all include the steps of:

(1) mixing evening primrose oil, squalane, calamine and zinc oxide, ball-milling, sieving with a 200-mesh sieve to uniformly disperse solids in liquid, and heating to 70-85 ℃ to obtain a first mixture;

(2) mixing the rest raw materials except the colloidal sulfur and the basic grease, heating to 60-95 ℃, stirring to completely dissolve the solid, and keeping the temperature open to completely volatilize the water to obtain a second mixture;

(3) adding the first mixture into the second mixture while stirring at the rotating speed of 500r/min, and then homogenizing for 5min to ensure that the materials are completely uniform, thereby obtaining a third mixture;

(4) cooling the third mixture while stirring, cooling to 45 ℃, adding colloidal sulfur, stirring uniformly, cooling to 40 ℃, adding base grease, and stirring uniformly;

(5) standing, and after the inspection is qualified, filling, packaging and code spraying;

(6) and (5) after the cream is qualified, warehousing to obtain the cream.

Comparative examples 1 to 6

Comparative examples 1 to 6 respectively provide creams for improving red buttocks of infants, the raw material compositions of the creams for improving red buttocks of infants are shown in table 2, and the preparation methods are the same as the examples.

Table 2 comparative examples 1-6 raw material composition/wt% of cream for improving red buttocks of infants

The colloidal state used in each of the examples and comparative examples comprised 25 wt% gum arabic and 75 wt% sulfur, produced by vanderus corporation, usa; the folium Perillae extract is prepared from folium Perillae and butanediol by mixing folium Perillae: the butanediol is prepared according to the mass ratio of 1:9, and a manufacturer is three scientific and technological development limited companies of Zhou of Chongqing; the evening primrose oil is prepared by a cold pressing process, and the manufacturer is North Star oil company in British.

Effect example 1: test for prevention of red buttocks

Test samples: examples 1-7, comparative examples 1-6 creams, and some commercial hip care cream.

Test objects: 150 healthy infants with the age of 3-12 months.

The test method comprises the following steps: 10 parts of each of the 14 samples are taken, randomly numbered and correspondingly recorded, the 140 samples are randomly distributed to mothers of 140 infants, the samples are required to be smeared on the buttocks of the infants according to the specification by the amount (1g) of the conventional hip protection cream, namely the buttocks are cleaned and then smeared, and the samples are washed clean by clear water after being smeared for about ten minutes (when the slightly smelly egg smell is smelled in the examples 1-7). Each diaper change and hip wash was used for one month continuously, and the change in hip (redness or redness) before and after the control use was observed daily. Any time the buttocks become red in any day during the use process, the effect is no longer effective. The remaining 10 infants did not use any product in the buttocks during this procedure.

And (3) testing results: as shown in table 3.

TABLE 3 test results

As can be seen from table 3, the cream for improving the red buttocks of infants and the commercial hip care cream in the comparative example are both effective in preventing the red buttocks of infants, but the cream of the invention has better effect in preventing the red buttocks of infants than the cream of the comparative example and the commercial hip care cream.

Effect example 2: test for relief of red buttocks

Test samples: examples 1-7, comparative examples 1-6 creams, and some commercial hip care cream.

Test objects: 150 infants who had developed red buttocks at 3-12 months of age.

The test method comprises the following steps: 10 parts of each of the 14 samples are taken, randomly numbered and correspondingly recorded, the 140 samples are randomly distributed to mothers of 140 infants, the samples are required to be smeared on the buttocks of the infants according to the specification by the amount (1g) of the conventional hip protection cream, namely the buttocks are cleaned and then smeared, and the samples are washed clean by clear water after being smeared for about ten minutes (when the slightly smelly egg smell is smelled in the examples 1-7). Each diaper change and hip wash was followed for three consecutive days and the red hip change (improvement) before and after the control was observed daily. It is effective to significantly reduce redness and itching starting three days after use. The remaining 10 infants did not use any product in the buttocks during this procedure.

And (3) testing results: as shown in table 4.

TABLE 4 test results

Sample (I)	Working examples
		Example 1	10
Example 2	10
		Example 3	10
Example 4	10
		Example 5	10
Example 6	10
		Example 7	10
Comparative example 1	7
		Comparative example 2	5
Comparative example 3	8
		Comparative example 4	8
Comparative example 5	7
		Comparative example 6	7
Commercially available hip-protecting cream	7
		Blank is not used	0

As can be seen from Table 4, the cream for improving the red buttocks of the infants and the commercial hip protection cream are effective in relieving the red buttocks of the infants, but the cream has better effect in relieving the red buttocks of the infants than the cream for the comparative example and the commercial hip protection cream.

Effect example 3: easy cleanability test

The above 80 mothers who used the present invention to improve the cream of red buttocks of infants and the commercial hip-protecting cream template were interviewed for satisfaction with the sample cleaning effect, wherein the use of the present invention all fed back very easy clean rinse, while the use of the 10 mothers of the commercial product all fed back inconvenient clean.

As can be seen from the feedback data, the cream for improving the red buttocks of the infants has more convenient cleaning effect than the commercial hip protection cream.

In conclusion, the cream for improving the red buttocks of the infants has better effects of preventing and relieving the red buttocks of the infants than the commercial hip protecting cream, and is more convenient to clean.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (9)

1. The cream for improving red buttocks of infants is characterized by being prepared from the following raw materials in percentage by weight: 5-30% of humectant, 0.5-10% of anti-irritant agent, 0.5-10% of enzyme activity inhibitor, 1-10% of colloidal sulfur, 25-80% of squalane, 1-50% of base oil, 0.1-2% of emulsifier, 1-5% of calamine and 5-20% of zinc oxide.

2. The cream according to claim 1, wherein the cream raw materials further comprise the following components in percentage by weight: 0.01-0.5% hexamidine di (isethionic acid) salt.

3. The cream of claim 1, wherein the humectant comprises glycerin.

4. The cream of claim 1, wherein the anti-irritant comprises perilla leaf extract.

5. The cream of claim 1, wherein the inhibitor of enzyme activity comprises evening primrose oil.

6. The cream of claim 1, wherein the emulsifier is a cationic emulsifier.

7. The cream of claim 6, wherein the cationic emulsifier is palmitoylamidopropyltrimethylammonium chloride.

8. The cream of claim 1, wherein the cream is free of water.

9. A method of preparing a correction paste as claimed in any one of claims 1 to 8, characterized in that it comprises the following steps:

(1) mixing enzyme activity inhibitor, squalane, calamine and zinc oxide, ball-milling, filtering to uniformly disperse solid in liquid, and heating to 70-85 ℃ to obtain a first mixture;

(2) mixing the rest raw materials except the colloidal sulfur and the basic grease, heating to 60-95 ℃, stirring to completely dissolve the solid, and keeping the temperature open to completely volatilize the water to obtain a second mixture;

(3) adding the first mixture into the second mixture while stirring, and then homogenizing to obtain a third mixture;

(4) and cooling the third mixture while stirring, cooling to below 45 ℃, adding colloidal sulfur, uniformly stirring, cooling to below 40 ℃, adding base oil, and uniformly stirring to obtain the cream.