CN105687353A - Pharmaceutical composition for infantile erythema glutealis and preparation method thereof - Google Patents

Pharmaceutical composition for infantile erythema glutealis and preparation method thereof Download PDF

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CN105687353A
CN105687353A CN201610049775.7A CN201610049775A CN105687353A CN 105687353 A CN105687353 A CN 105687353A CN 201610049775 A CN201610049775 A CN 201610049775A CN 105687353 A CN105687353 A CN 105687353A
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parts
pharmaceutical composition
erythema
powder
herba
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隋妍蕾
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Abstract

The invention discloses a pharmaceutical composition for infantile erythema glutealis and a preparation method thereof. The composition is prepared from main materials and auxiliary materials, wherein the main materials are toona microcarpa, melothria indica, Brucea javanica, pungent litsea root, ranunculus glacialis, artemisia stelleriana flowers and Nanocnide japonica; the auxiliary materials are Cardamine hirsuta, eucalyptus globulus, Melia toosendan, garcinia mangostana, pine wood bark, maifanite powder, nano titanium dioxide, magnesium carbonate, polydimethylsiloxane, wallantoin, an antibacterial agent, an antiphlogistic and a natural antioxidant. According to the pharmaceutical composition for the infantile erythema glutealis and the preparation method thereof, the material selecting is rigorous, and the combining is reasonable, so that the pharmaceutical composition has the effects of clearing heat and drying dampness, astringing dampness and promoting wound healing, diminishing inflammation and alleviating pain, preventing corrosion and relieving itching, absorbing moisture and preventing corrosion, regulating skin moisture and promoting cell growth; the materials do not react mutually and can complement benefits and be in synergism, so that the pharmaceutical composition is used for effectively treating the infantile erythema glutealis, is non-toxic and non-irritant and is beneficial to the healthful growth of infants; according to the pharmaceutical composition, the selected pharmaceutical raw materials are wide in source and are cheap and readily available, the preparation process is simple, and the preparation cost is low, so that the pharmaceutical composition is applicable to ordinary consumers.

Description

A kind of pharmaceutical composition for baby buttocks erythema and preparation method thereof
Technical field
The present invention relates to pharmaceutical techniques field, be specifically related to a kind of pharmaceutical composition for baby buttocks erythema and preparation method thereof。
Background technology
Baby buttocks erythema is the contact dermatitis that the diapers such as baby's perianal and buttocks hide that position occurs。Primary disease is similar to " the flooding buttocks skin ulcer ", " monkey infantile malnutrition " of the traditional Chinese medical science, records as " surgery opens profound " floods buttocks skin ulcer: " breast child was stretched tight and tied up brothers and nourish gas damp and hot in jowl limb nest lower limb puerperal period, often all flooded into skin ulcer "。And for example " surgery card control pandect " monkey infantile malnutrition is recorded: " be card children's Duo get it, from anus or scrotum limit blush rotten, gradually to skin "。
Baby buttocks erythema is again diaper dermatitis, takes place mostly in nursling, and skin lesion is typically restricted to the position of touching diaper, such as the portion such as inside buttocks protruded part external genital, lower abdomen and stock。It is suitable that its scope and diaper hide position。Skin lesion onset is slight flushing, swelling, may occur in which that pimple, vesicle, erosion are oozed out gradually, and disease damage boundary is clear。Process has secondary bacterial or monilial infection person, may occur in which pustule and fester etc.。How due to diaper change not in time baby buttocks erythema produces pungent cause mainly due to urine, excrement, especially add with plastics, rubberized fabric, oilcloth, make local skin be in humidity or impregnation state。It addition, diaper washing is unclean, residual urine stain and feces are easily decomposed by metatroph and produce Ammonia material incentive skin and also can cause diaper dermatitis。Sometimes, the dyestuff on diaper, remaining soap and rubber or plastics can become stimulating factor sometimes, bring out primary disease。
Diaper has substituted ordinary diapers gradually, even universal in big city, major part diaper is substantially non-woven fabrics surface layer, Breathable nonwoven can promote the ventilative degree within urine pants, steam can be circulated to beyond diaper, discharging dampness, steam in time, effectively reduce eczema occurrence probability, soft comfortable does not stimulate skin。But also having ropy diaper, permeability is poor, heat dispersion is also not ideal enough。But in rural area and remote mountain areas, the level of consumption of people, but without catching up with, uses the still a lot of of ordinary diapers。If obtaining diaper dermatitis can not treat in time, then can affect infantile health and grow up。
Summary of the invention
Present invention solves the technical problem that and be to provide a kind of pharmaceutical composition for baby buttocks erythema and preparation method thereof, it is possible to effectively treatment baby buttocks erythema, gentleness does not stimulate, and production cost is low。
The technical scheme is that, a kind of pharmaceutical composition for baby buttocks erythema, it is made up of major ingredient and adjuvant, by weight, described major ingredient is: purple Chinese toon 100～200 parts, horse hail 100～150 parts, 90～150 parts of gallbladder roots of crow, Radix Litseae pungentis 80～120 parts, Herba oxygraphis glacialis 60～100 parts, Herba Artemisiae Sieversianae 60～90 parts, Herba Nanocnides Japonicae 60～80 parts；Described adjuvant is: Hairy Bittercress 30～40 parts, Eucalyptus globulus Labill 20～35 parts, Folium meliae 15～30 parts, Cortex Garciniae 5～10 parts, Cortex Pini Massonianae 4～10 parts, medical stone powder 5～8 parts, nano titanium oxide 3～6 parts, magnesium carbonate 2～3 parts, polydimethylsiloxane 1～2 part, allantoin 1～1.5 part, antibacterial 0.9～1.5 part, antiinflammatory 0.5～1.5 part, the Natural antioxidant 0.3～1.5 part, vitamin K 0.1～0.5 part。
Further, described a kind of pharmaceutical composition for baby buttocks erythema, by weight, described major ingredient is: purple Chinese toon 150 parts, horse hail 125 parts, 120 parts of gallbladder roots of crow, Radix Litseae pungentis 100 parts, Herba oxygraphis glacialis 80 parts, Herba Artemisiae Sieversianae 75 parts, Herba Nanocnides Japonicae 70 parts；Described adjuvant is: Hairy Bittercress 35 parts, Eucalyptus globulus Labill 27.5 parts, Folium meliae 22.5 parts, Cortex Garciniae 7.5 parts, Cortex Pini Massonianae 7 parts, medical stone powder 6.5 parts, nano titanium oxide 4.5 parts, magnesium carbonate 2.5 parts, polydimethylsiloxane 1.5 parts, allantoin 1.25 parts, antibacterial 1.2 parts, antiinflammatory 1 part, the Natural antioxidant 0.9 part, vitamin K 0.3 part。
Further, described vitamin K is to be formed by the proportions of 1:1:1:1:1:1 by vitamin K1, Menaquinone K6, vitamin K3, methylnaphthohydroquinone, vitamin K5, vitamin K6, has good coagulant property, it is prevented that tattered skin is bled。
Further, described antibacterial chlorogenic acid, chlorogenic acid antibacterial range is wide。
Further, described antiinflammatory is Radix Oenotherae erythrosepalae oil, can suppress inflammation, and anti-inflammatory is good, moreover it is possible to improve eczema。
Further, the described Natural antioxidant is Jojoba oil, not only effective antioxidation, and skin-friendly is good, regulation of skin moisture。
Further, the particle diameter of described nano titanium oxide is 20～50nm, and titanium dioxide particle diameter is more little, and its specific surface area is more big, and performance is more excellent。
Further, the particle diameter of described medical stone powder is 10～50 μm, and the particle diameter of medical stone powder is more little, and its hygroscopicity is more good。
The preparation method of a kind of pharmaceutical composition for baby buttocks erythema, comprises the following steps:
(1) weigh purple Chinese toon, Herba oxygraphis glacialis, Cortex Garciniae, Cortex Pini Massonianae by described proportioning, dry, pulverize into coarse powder, then be placed in super micron mill and pulverize, cross 200～300 sieves, obtain micro-powder of Chinese herbs。
(2) Radix Bruceae, Herba Artemisiae Sieversianae, Herba Nanocnides Japonicae, Eucalyptus globulus Labill, Folium meliae are weighed by described proportioning, it is ground into coarse powder, mixing, obtain mixture, add the deionized water relative to mixture quality 10～15 times, after boiling, little fire decocts extraction 1～2 hour, is filtrated to get first time aqueous extract and medicinal residues；Adding obtaining medicinal residues after first time water extraction step in deionized water, the quality of deionized water is 5～10 times of medicinal residues quality, and after boiling, little fire decocts extraction 1～2 hour, is filtrated to get second time aqueous extract；Being mixed with second time aqueous extract by first time aqueous extract, filter and centrifugal acquisition supernatant in centrifugal separator, and carry out concentrating under reduced pressure on a rotary evaporator, adopt pneumatic spray drying method, spray drying makes powder, obtains water extract。
(3) weigh horse hail, Radix Litseae pungentis, Hairy Bittercress by described proportioning, be ground into coarse powder, mixing；Adopting mass concentration successively is by the ethanol/water solution of 90wt.%, 70wt.%, 55wt.%, alcohol extract dispensing is carried out step-SHENLU, and collect the percolate produced in three percolation processes respectively, in each percolation process, the ethanol/water solution of every gram of alcohol extract dispensing correspondence 4～6ml, after the percolate that three percolation are obtained mixing, on a rotary evaporator, carry out concentrating under reduced pressure, obtain alcohol extraction concentrated solution；Alcohol extraction concentrated solution is added in 1,3 butanediol and carries out sucking filtration, the centrifugal extraction supernatant on the centrifugal separator that rotating speed is 2000～4000 revs/min, and carry out concentrating under reduced pressure on a rotary evaporator, adopting pneumatic spray drying method, spray drying makes powder, obtains alcohol extract。
(4) medical stone powder is weighed by described proportioning, nano titanium oxide, magnesium carbonate, polydimethylsiloxane, allantoin, antibacterial, antiinflammatory, the Natural antioxidant, vitamin K, by above-mentioned gained micro-powder of Chinese herbs, water extract, alcohol extract merges, add described medical stone powder, nano titanium oxide, magnesium carbonate, polydimethylsiloxane, allantoin, antibacterial, vitamin K, it is placed in blender and stirs, it is fully ground with grinder, again antiinflammatory and Natural antioxidant aerosol apparatus are uniformly sprayed onto in the mixture after stirring, packaging, every bag of 6～10g, ?。
Usage and consumption: after the cleaning of affected part, dry, take this pharmaceutical composition 2～3g, uniformly clap by powder puff or other instrument and be sprinkled upon affected part。
The invention has the beneficial effects as follows: the present invention selects materials rigorous for the pharmaceutical composition of baby buttocks erythema, wherein, purple Chinese toon, Radix Bruceae, Radix Litseae pungentis, Herba oxygraphis glacialis has the effect of heat clearing and damp drying, horse hail, Herba Artemisiae Sieversianae, Herba Nanocnides Japonicae has heat-clearing and toxic substances removing, effect of removing dampness sore, is aided with Eucalyptus globulus Labill, Cortex Garciniae, it is possible to anti-inflammatory analgetic, anticorrosion is antipruritic, Hairy Bittercress, Folium meliae, Cortex Pini Massonianae removes wind prevailing over dampness, controls eczema and scratches where it itches, and it is good to add medical stone powder moisture sorption effect, has antisepsis, and nano titanium oxide adhesiveness is good, and covering power is strong, effectively stops urine to invade compromised skin, magnesium carbonate, polydimethylsiloxane, allantoin is nontoxic non-stimulated, can promote Growth of Cells, accelerates wound healing, horny layer softening albumen, chlorogenic acid antibacterial range is wide, and the antiphlogistic effects of Radix Oenotherae erythrosepalae oil is good, Jojoba oil has natural anti-oxidation, vitamin K prevention wound bleeding, and each component compatibility is reasonable, do not react each other, and can complementary benifit, combined effect, effectively treatment baby buttocks erythema, and nontoxic nonirritant, be conducive to infantile health to grow up。It addition, medicine material wide material sources selected by the present invention, being easy to get at a low price, preparation technology is simple, low cost of manufacture, is suitable for ordinary consumer and uses。
Detailed description of the invention
Embodiment 1:
A kind of pharmaceutical composition for baby buttocks erythema, is made up of major ingredient and adjuvant, and by weight, described major ingredient is: purple Chinese toon 100 parts, horse hail 100 parts, 90 parts of gallbladder roots of crow, Radix Litseae pungentis 80 parts, Herba oxygraphis glacialis 60 parts, Herba Artemisiae Sieversianae 60 parts, Herba Nanocnides Japonicae 60 parts；Described adjuvant is: Hairy Bittercress 30 parts, Eucalyptus globulus Labill 20 parts, Folium meliae 15 parts, Cortex Garciniae 5 parts, Cortex Pini Massonianae 4 parts, medical stone powder 5 parts, nano titanium oxide 3 parts, magnesium carbonate 2 parts, polydimethylsiloxane 1 part, allantoin 1 part, antibacterial 0.9 part, antiinflammatory 0.5 part, the Natural antioxidant 0.3 part, vitamin K 0.1 part。
Wherein, described vitamin K is to be formed by the proportions of 1:1:1:1:1:1 by vitamin K1, Menaquinone K6, vitamin K3, methylnaphthohydroquinone, vitamin K5, vitamin K6, has good coagulant property, it is prevented that tattered skin is bled。Described antibacterial chlorogenic acid, chlorogenic acid antibacterial range is wide。Described antiinflammatory is Radix Oenotherae erythrosepalae oil, can suppress inflammation, and anti-inflammatory is good, moreover it is possible to improve eczema。The described Natural antioxidant is Jojoba oil, not only effective antioxidation, and skin-friendly is good, regulation of skin moisture。The particle diameter of described nano titanium oxide is 20nm, and titanium dioxide particle diameter is more little, and its specific surface area is more big, and performance is more excellent。The particle diameter of described medical stone powder is 10 μm, and the particle diameter of medical stone powder is more little, and its hygroscopicity is more good。
This is used for the preparation method of pharmaceutical composition of baby buttocks erythema, comprises the following steps:
(1) weigh purple Chinese toon, Herba oxygraphis glacialis, Cortex Garciniae, Cortex Pini Massonianae by described proportioning, dry, pulverize into coarse powder, then be placed in super micron mill and pulverize, cross 200 sieves, obtain micro-powder of Chinese herbs；
(2) weigh Radix Bruceae, Herba Artemisiae Sieversianae, Herba Nanocnides Japonicae, Eucalyptus globulus Labill, Folium meliae by described proportioning, be ground into coarse powder, mixing, obtain mixture, adding the deionized water relative to mixture quality 10 times, after boiling, little fire decocts and extracts 1 hour, is filtrated to get first time aqueous extract and medicinal residues；Adding obtaining medicinal residues after first time water extraction step in deionized water, the quality of deionized water is 5 times of medicinal residues quality, and after boiling, little fire decocts and extracts 1 hour, is filtrated to get second time aqueous extract；Being mixed with second time aqueous extract by first time aqueous extract, filter and centrifugal acquisition supernatant in centrifugal separator, and carry out concentrating under reduced pressure on a rotary evaporator, adopt pneumatic spray drying method, spray drying makes powder, obtains water extract；
(3) weigh horse hail, Radix Litseae pungentis, Hairy Bittercress by described proportioning, be ground into coarse powder, mixing；Adopting mass concentration successively is by the ethanol/water solution of 90wt.%, 70wt.%, 55wt.%, alcohol extract dispensing is carried out step-SHENLU, and collect the percolate produced in three percolation processes respectively, in each percolation process, the ethanol/water solution of every gram of alcohol extract dispensing correspondence 4ml, after the percolate that three percolation are obtained mixing, on a rotary evaporator, carry out concentrating under reduced pressure, obtain alcohol extraction concentrated solution；Alcohol extraction concentrated solution is added in 1,3 butanediol and carries out sucking filtration, the centrifugal extraction supernatant on the centrifugal separator that rotating speed is 2000 revs/min, and carry out concentrating under reduced pressure on a rotary evaporator, adopting pneumatic spray drying method, spray drying makes powder, obtains alcohol extract；
(4) medical stone powder is weighed by described proportioning, nano titanium oxide, magnesium carbonate, polydimethylsiloxane, allantoin, antibacterial, antiinflammatory, the Natural antioxidant, vitamin K, by above-mentioned gained micro-powder of Chinese herbs, water extract, alcohol extract merges, add described medical stone powder, nano titanium oxide, magnesium carbonate, polydimethylsiloxane, allantoin, antibacterial, vitamin K, it is placed in blender and stirs, it is fully ground with grinder, again antiinflammatory and Natural antioxidant aerosol apparatus are uniformly sprayed onto in the mixture after stirring, packaging, every bag of 6g, ?。
Embodiment 2:
A kind of pharmaceutical composition for baby buttocks erythema, it is made up of major ingredient and adjuvant, by weight, described major ingredient is: purple Chinese toon 150 parts, horse hail 125 parts, 120 parts of gallbladder roots of crow, Radix Litseae pungentis 100 parts, Herba oxygraphis glacialis 80 parts, Herba Artemisiae Sieversianae 75 parts, Herba Nanocnides Japonicae 70 parts；Described adjuvant is: Hairy Bittercress 35 parts, Eucalyptus globulus Labill 27.5 parts, Folium meliae 22.5 parts, Cortex Garciniae 7.5 parts, Cortex Pini Massonianae 7 parts, medical stone powder 6.5 parts, nano titanium oxide 4.5 parts, magnesium carbonate 2.5 parts, polydimethylsiloxane 1.5 parts, allantoin 1.25 parts, antibacterial 1.2 parts, antiinflammatory 1 part, the Natural antioxidant 0.9 part, vitamin K 0.3 part。
Wherein, described vitamin K is to be formed by the proportions of 1:1:1:1:1:1 by vitamin K1, Menaquinone K6, vitamin K3, methylnaphthohydroquinone, vitamin K5, vitamin K6, has good coagulant property, it is prevented that tattered skin is bled。Described antibacterial chlorogenic acid, chlorogenic acid antibacterial range is wide。Described antiinflammatory is Radix Oenotherae erythrosepalae oil, can suppress inflammation, and anti-inflammatory is good, moreover it is possible to improve eczema。The described Natural antioxidant is Jojoba oil, not only effective antioxidation, and skin-friendly is good, regulation of skin moisture。The particle diameter of described nano titanium oxide is 35nm, and titanium dioxide particle diameter is more little, and its specific surface area is more big, and performance is more excellent。The particle diameter of described medical stone powder is 30 μm, and the particle diameter of medical stone powder is more little, and its hygroscopicity is more good。
This is used for the preparation method of pharmaceutical composition of baby buttocks erythema, comprises the following steps:
(1) weigh purple Chinese toon, Herba oxygraphis glacialis, Cortex Garciniae, Cortex Pini Massonianae by described proportioning, dry, pulverize into coarse powder, then be placed in super micron mill and pulverize, cross 250 sieves, obtain micro-powder of Chinese herbs；
(2) weigh Radix Bruceae, Herba Artemisiae Sieversianae, Herba Nanocnides Japonicae, Eucalyptus globulus Labill, Folium meliae by described proportioning, be ground into coarse powder, mixing, obtain mixture, adding the deionized water relative to mixture quality 12.5 times, after boiling, little fire decocts and extracts 1.5 hours, is filtrated to get first time aqueous extract and medicinal residues；Adding obtaining medicinal residues after first time water extraction step in deionized water, the quality of deionized water is 7.5 times of medicinal residues quality, and after boiling, little fire decocts and extracts 1.5 hours, is filtrated to get second time aqueous extract；Being mixed with second time aqueous extract by first time aqueous extract, filter and centrifugal acquisition supernatant in centrifugal separator, and carry out concentrating under reduced pressure on a rotary evaporator, adopt pneumatic spray drying method, spray drying makes powder, obtains water extract；
(3) weigh horse hail, Radix Litseae pungentis, Hairy Bittercress by described proportioning, be ground into coarse powder, mixing；Adopting mass concentration successively is by the ethanol/water solution of 90wt.%, 70wt.%, 55wt.%, alcohol extract dispensing is carried out step-SHENLU, and collect the percolate produced in three percolation processes respectively, in each percolation process, the ethanol/water solution of every gram of alcohol extract dispensing correspondence 5ml, after the percolate that three percolation are obtained mixing, on a rotary evaporator, carry out concentrating under reduced pressure, obtain alcohol extraction concentrated solution；Alcohol extraction concentrated solution is added in 1,3 butanediol and carries out sucking filtration, the centrifugal extraction supernatant on the centrifugal separator that rotating speed is 3000 revs/min, and carry out concentrating under reduced pressure on a rotary evaporator, adopting pneumatic spray drying method, spray drying makes powder, obtains alcohol extract；
(4) medical stone powder is weighed by described proportioning, nano titanium oxide, magnesium carbonate, polydimethylsiloxane, allantoin, antibacterial, antiinflammatory, the Natural antioxidant, vitamin K, by above-mentioned gained micro-powder of Chinese herbs, water extract, alcohol extract merges, add described medical stone powder, nano titanium oxide, magnesium carbonate, polydimethylsiloxane, allantoin, antibacterial, vitamin K, it is placed in blender and stirs, it is fully ground with grinder, again antiinflammatory and Natural antioxidant aerosol apparatus are uniformly sprayed onto in the mixture after stirring, packaging, every bag of 8g, ?。
Embodiment 3:
A kind of pharmaceutical composition for baby buttocks erythema, it is made up of major ingredient and adjuvant, by weight, described major ingredient is: purple Chinese toon 200 parts, horse hail 150 parts, 150 parts of gallbladder roots of crow, Radix Litseae pungentis 120 parts, Herba oxygraphis glacialis 100 parts, Herba Artemisiae Sieversianae 90 parts, Herba Nanocnides Japonicae 80 parts；Described adjuvant is: Hairy Bittercress 40 parts, Eucalyptus globulus Labill 35 parts, Folium meliae 30 parts, Cortex Garciniae 10 parts, Cortex Pini Massonianae 10 parts, medical stone powder 8 parts, nano titanium oxide 6 parts, magnesium carbonate 3 parts, polydimethylsiloxane 2 parts, allantoin 1.5 parts, antibacterial 1.5 parts, antiinflammatory 1.5 parts, the Natural antioxidant 1.5 parts, vitamin K 0.5 part。
Wherein, described vitamin K is to be formed by the proportions of 1:1:1:1:1:1 by vitamin K1, Menaquinone K6, vitamin K3, methylnaphthohydroquinone, vitamin K5, vitamin K6, has good coagulant property, it is prevented that tattered skin is bled。Described antibacterial chlorogenic acid, chlorogenic acid antibacterial range is wide。Described antiinflammatory is Radix Oenotherae erythrosepalae oil, can suppress inflammation, and anti-inflammatory is good, moreover it is possible to improve eczema。The described Natural antioxidant is Jojoba oil, not only effective antioxidation, and skin-friendly is good, regulation of skin moisture。The particle diameter of described nano titanium oxide is 50nm, and titanium dioxide particle diameter is more little, and its specific surface area is more big, and performance is more excellent。The particle diameter of described medical stone powder is 50 μm, and the particle diameter of medical stone powder is more little, and its hygroscopicity is more good。
This is used for the preparation method of pharmaceutical composition of baby buttocks erythema, comprises the following steps:
(1) weigh purple Chinese toon, Herba oxygraphis glacialis, Cortex Garciniae, Cortex Pini Massonianae by described proportioning, dry, pulverize into coarse powder, then be placed in super micron mill and pulverize, cross 300 sieves, obtain micro-powder of Chinese herbs；
(2) weigh Radix Bruceae, Herba Artemisiae Sieversianae, Herba Nanocnides Japonicae, Eucalyptus globulus Labill, Folium meliae by described proportioning, be ground into coarse powder, mixing, obtain mixture, adding the deionized water relative to mixture quality 15 times, after boiling, little fire decocts and extracts 2 hours, is filtrated to get first time aqueous extract and medicinal residues；Adding obtaining medicinal residues after first time water extraction step in deionized water, the quality of deionized water is 10 times of medicinal residues quality, and after boiling, little fire decocts and extracts 2 hours, is filtrated to get second time aqueous extract；Being mixed with second time aqueous extract by first time aqueous extract, filter and centrifugal acquisition supernatant in centrifugal separator, and carry out concentrating under reduced pressure on a rotary evaporator, adopt pneumatic spray drying method, spray drying makes powder, obtains water extract；
(3) weigh horse hail, Radix Litseae pungentis, Hairy Bittercress by described proportioning, be ground into coarse powder, mixing；Adopting mass concentration successively is by the ethanol/water solution of 90wt.%, 70wt.%, 55wt.%, alcohol extract dispensing is carried out step-SHENLU, and collect the percolate produced in three percolation processes respectively, in each percolation process, the ethanol/water solution of every gram of alcohol extract dispensing correspondence 4～6ml, after the percolate that three percolation are obtained mixing, on a rotary evaporator, carry out concentrating under reduced pressure, obtain alcohol extraction concentrated solution；Alcohol extraction concentrated solution is added in 1,3 butanediol and carries out sucking filtration, the centrifugal extraction supernatant on the centrifugal separator that rotating speed is 4000 revs/min, and carry out concentrating under reduced pressure on a rotary evaporator, adopting pneumatic spray drying method, spray drying makes powder, obtains alcohol extract；
(4) medical stone powder is weighed by described proportioning, nano titanium oxide, magnesium carbonate, polydimethylsiloxane, allantoin, antibacterial, antiinflammatory, the Natural antioxidant, vitamin K, by above-mentioned gained micro-powder of Chinese herbs, water extract, alcohol extract merges, add described medical stone powder, nano titanium oxide, magnesium carbonate, polydimethylsiloxane, allantoin, antibacterial, vitamin K, it is placed in blender and stirs, it is fully ground with grinder, again antiinflammatory and Natural antioxidant aerosol apparatus are uniformly sprayed onto in the mixture after stirring, packaging, every bag of 10g, ?。
Clinical practice:
1, clinical data: totally 80 example, wherein girl baby 46 example, boy baby 34 example；The oldest 10 months, minimum 1 month。Diagnostic criteria: skin lesion onset is slight flushing, swelling, pimple, vesicle, erosion, pustule；Predilection site: the position of touching diaper, as inside buttocks protruded part, external genital, hypogastric region and stock etc.；Being mainly in nursling, the weight summer in winter is light。In 80 example patients, buttocks is slight flushing, struttuer 27 example, pimple, vesicle, the erosion person of oozing out 38 example, pustule and fester person 15 example。
2, Therapeutic Method: using the pharmaceutical composition for baby buttocks erythema prepared by the present invention, after being cleaned in baby affected part, dry, take this pharmaceutical composition 2～3g, uniformly clap by powder puff or other instrument and be sprinkled upon affected part, a day 2～3 times, 7 days be a course for the treatment of。
3, criterion of therapeutical effect: recovery from illness: after terminating the course for the treatment of, skin lesion, erythema disappear, and skin of buttock surface recovers normal completely；Taking a turn for the better: skin lesion scope is obviously reduced, and oozes out and stopped bleeding, the incrustation of rotten to the corn place, skin lesion place dries；Invalid: skin lesion place is without being clearly better or increasing the weight of。With recovery from illness and the calculating total effective rate that takes a turn for the better。
4, therapeutic outcome: infant treatment observes curative effect after 1 course for the treatment of, and 80 example infants are wherein fully recovered 61 examples (76.25%), 18 examples that take a turn for the better (22.5%), invalid 1 example (1.25%), total effective rate 98.75%。All infants before the treatment after, breathing, heart rate, pulse frequency, blood pressure, blood, urine,, all there is not untoward reaction in the equal Non Apparent Abnormality change of stool routine, hepatic and renal function and electrocardiogram during observation, proving that human body is had no adverse reaction by above-mentioned Chinese medicine oil preparation, safety is good, does not stimulate。
With the above-mentioned desirable embodiment according to the present invention for enlightenment, by above-mentioned description, relevant staff in the scope not necessarily departing from this invention technological thought, can carry out various change and amendment completely。The technical scope of this invention is not limited to the content in description, it is necessary to determine its technical scope according to right。

Claims (8)

1. the pharmaceutical composition for baby buttocks erythema, it is characterized in that, it is made up of major ingredient and adjuvant, by weight, described major ingredient is: purple Chinese toon 100～200 parts, horse hail 100～150 parts, 90～150 parts of gallbladder roots of crow, Radix Litseae pungentis 80～120 parts, Herba oxygraphis glacialis 60～100 parts, Herba Artemisiae Sieversianae 60～90 parts, Herba Nanocnides Japonicae 60～80 parts；Described adjuvant is: Hairy Bittercress 30～40 parts, Eucalyptus globulus Labill 20～35 parts, Folium meliae 15～30 parts, Cortex Garciniae 5～10 parts, Cortex Pini Massonianae 4～10 parts, medical stone powder 5～8 parts, nano titanium oxide 3～6 parts, magnesium carbonate 2～3 parts, polydimethylsiloxane 1～2 part, allantoin 1～1.5 part, antibacterial 0.9～1.5 part, antiinflammatory 0.5～1.5 part, the Natural antioxidant 0.3～1.5 part, vitamin K 0.1～0.5 part。
2. a kind of pharmaceutical composition for baby buttocks erythema and preparation method thereof as claimed in claim 1, it is characterized in that, it is made up of major ingredient and adjuvant, by weight, described major ingredient is: purple Chinese toon 150 parts, horse hail 125 parts, 120 parts of gallbladder roots of crow, Radix Litseae pungentis 100 parts, Herba oxygraphis glacialis 80 parts, Herba Artemisiae Sieversianae 75 parts, Herba Nanocnides Japonicae 70 parts；Described adjuvant is: Hairy Bittercress 35 parts, Eucalyptus globulus Labill 27.5 parts, Folium meliae 22.5 parts, Cortex Garciniae 7.5 parts, Cortex Pini Massonianae 7 parts, medical stone powder 6.5 parts, nano titanium oxide 4.5 parts, magnesium carbonate 2.5 parts, polydimethylsiloxane 1.5 parts, allantoin 1.25 parts, antibacterial 1.2 parts, antiinflammatory 1 part, the Natural antioxidant 0.9 part, vitamin K 0.3 part。
3. a kind of pharmaceutical composition for baby buttocks erythema as claimed in claim 1 or 2, it is characterised in that described antibacterial is chlorogenic acid。
4. a kind of pharmaceutical composition for baby buttocks erythema as claimed in claim 1 or 2, it is characterised in that described antiinflammatory is Radix Oenotherae erythrosepalae oil。
5. a kind of pharmaceutical composition for baby buttocks erythema as claimed in claim 1 or 2, it is characterised in that the described Natural antioxidant is Jojoba oil。
6. a kind of pharmaceutical composition for baby buttocks erythema as claimed in claim 1 or 2, it is characterised in that the particle diameter of described nano titanium oxide is 20～50nm。
7. a kind of pharmaceutical composition for baby buttocks erythema as claimed in claim 1 or 2, it is characterised in that the particle diameter of described medical stone powder is 10～50 μm。
8. the preparation method of a kind of pharmaceutical composition for baby buttocks erythema as described in claim 1～7 any one, it is characterised in that comprise the following steps:
(1) weigh purple Chinese toon, Herba oxygraphis glacialis, Cortex Garciniae, Cortex Pini Massonianae by described proportioning, dry, pulverize into coarse powder, then be placed in super micron mill and pulverize, cross 200～300 sieves, obtain micro-powder of Chinese herbs。
(2) Radix Bruceae, Herba Artemisiae Sieversianae, Herba Nanocnides Japonicae, Eucalyptus globulus Labill, Folium meliae are weighed by described proportioning, it is ground into coarse powder, mixing, obtain mixture, add the deionized water relative to mixture quality 10～15 times, after boiling, little fire decocts extraction 1～2 hour, is filtrated to get first time aqueous extract and medicinal residues；Adding obtaining medicinal residues after first time water extraction step in deionized water, the quality of deionized water is 5～10 times of medicinal residues quality, and after boiling, little fire decocts extraction 1～2 hour, is filtrated to get second time aqueous extract；Being mixed with second time aqueous extract by first time aqueous extract, filter and centrifugal acquisition supernatant in centrifugal separator, and carry out concentrating under reduced pressure on a rotary evaporator, adopt pneumatic spray drying method, spray drying makes powder, obtains water extract。
(3) weigh horse hail, Radix Litseae pungentis, Hairy Bittercress by described proportioning, be ground into coarse powder, mixing；Adopting mass concentration successively is by the ethanol/water solution of 90wt.%, 70wt.%, 55wt.%, alcohol extract dispensing is carried out step-SHENLU, and collect the percolate produced in three percolation processes respectively, in each percolation process, the ethanol/water solution of every gram of alcohol extract dispensing correspondence 4～6ml, after the percolate that three percolation are obtained mixing, on a rotary evaporator, carry out concentrating under reduced pressure, obtain alcohol extraction concentrated solution；Alcohol extraction concentrated solution is added in 1,3 butanediol and carries out sucking filtration, the centrifugal extraction supernatant on the centrifugal separator that rotating speed is 2000～4000 revs/min, and carry out concentrating under reduced pressure on a rotary evaporator, adopting pneumatic spray drying method, spray drying makes powder, obtains alcohol extract。
(4) medical stone powder, nano titanium oxide, magnesium carbonate, polydimethylsiloxane, allantoin, antibacterial, antiinflammatory, the Natural antioxidant, vitamin K are weighed by described proportioning, above-mentioned gained micro-powder of Chinese herbs, water extract, alcohol extract are merged, add described medical stone powder, nano titanium oxide, magnesium carbonate, polydimethylsiloxane, allantoin, antibacterial, antiinflammatory, the Natural antioxidant, vitamin K, it is placed in blender and stirs, packaging,。
CN201610049775.7A 2016-01-25 2016-01-25 Pharmaceutical composition for infantile erythema glutealis and preparation method thereof Pending CN105687353A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107308050A (en) * 2017-07-06 2017-11-03 陈瑞琼 A kind of dusting powder for infants
CN112402273A (en) * 2020-12-01 2021-02-26 金发拉比妇婴童用品股份有限公司 Cream for improving red buttocks of infants and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1300223A (en) * 1998-03-12 2001-06-20 宝洁公司 Disposable absorbent article having a skin care composition containing an enzyme inhibitor
CN103110724A (en) * 2012-12-11 2013-05-22 余金标 Traditional Chinese medicine for treating diaper dermatitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1300223A (en) * 1998-03-12 2001-06-20 宝洁公司 Disposable absorbent article having a skin care composition containing an enzyme inhibitor
CN103110724A (en) * 2012-12-11 2013-05-22 余金标 Traditional Chinese medicine for treating diaper dermatitis

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107308050A (en) * 2017-07-06 2017-11-03 陈瑞琼 A kind of dusting powder for infants
CN112402273A (en) * 2020-12-01 2021-02-26 金发拉比妇婴童用品股份有限公司 Cream for improving red buttocks of infants and preparation method thereof
CN112402273B (en) * 2020-12-01 2023-10-03 金发拉比妇婴童用品股份有限公司 Cream for improving red buttocks of infants and preparation method of cream

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