CN105997785B - A kind of stern protection cream for baby and preparation method thereof - Google Patents

A kind of stern protection cream for baby and preparation method thereof Download PDF

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Publication number
CN105997785B
CN105997785B CN201610422496.0A CN201610422496A CN105997785B CN 105997785 B CN105997785 B CN 105997785B CN 201610422496 A CN201610422496 A CN 201610422496A CN 105997785 B CN105997785 B CN 105997785B
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baby
extract
protection cream
added
stern protection
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CN105997785A (en
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熊延靖
李怀斌
董群
陈京
刘辉
杨成
杨雅倩
刘安
方毓楠
蔡天鑫
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Wannan Medical College
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Wannan Medical College
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A61K8/988—Honey; Royal jelly, Propolis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
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    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2236/55—Liquid-liquid separation; Phase separation
    • A—HUMAN NECESSITIES
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    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Abstract

The invention discloses a kind of stern protection cream for baby and preparation method thereof, by the way that aloe extract is added into 0.9% sodium chloride solution, tea polyphenols, honey, carrot juice and golden sunflower extract, aqueous phase substrate is made, the viscosity of matrix is adjusted with cornstarch again, it is eventually adding sesame oil, glycerine, sunflower oil oil-phase component, a kind of product of water-in-oil type is made, it uses pure plant formula, without any stimulating component, protective film can be formed in baby's skin surface and moisten baby's skin of buttock, urine is avoided directly to stimulate skin, effectively help the generation for preventing eczema and the inflammation caused by urine stimulation, it can be effectively relieved rubescent caused by eczema, skin around the rectum can also be protected and flesh tissue is promoted to grow, effectively alleviate rubefaction, obtain satisfactory effect, reduce infants' pain.

Description

A kind of stern protection cream for baby and preparation method thereof
Technical field
The invention belongs to baby's daily chemical product fields, and in particular to a kind of stern protection cream for baby and preparation method thereof.
Background technology
Newborn diapers dermatitis (diaper dermatitis) is commonly called as that diaper rash, stern be red or red stern, is non-neonate one The common and multiple skin lesion disease of kind, it is more conventional especially in Neonatal Ward.Report newborn diapers skin both at home and abroad Scorching incidence is 14.1%~35.1%, and newborn diapers dermatitis has become a thorny problem of Neonatal Ward nursing.
Currently there are infant buttocks-care cream brand it is more, ingredient is also varied, but therein main Ingredient is mostly sodium lactate, silicone oil, zinc oxide, and the more or less skin to baby of these ingredients has certain irritation.
Invention content
In view of the deficiencies of the prior art, the present invention provides a kind of stern protection cream for baby and preparation method thereof, use pure Plant formula is free of any stimulating component, can form protective film in baby's skin surface and moisten baby's skin of buttock, keep away Exempting from urine directly stimulates skin, effectively helps the inflammation caused by the generation for preventing eczema and urine stimulation, can effectively delay It is rubescent caused by solution eczema, it can also protect skin around the rectum and flesh tissue is promoted to grow, effectively alleviate rubefaction, obtain Satisfactory effect reduces infants' pain.
The technical solution adopted by the present invention is：
A kind of stern protection cream for baby contains following substance and weight percent：
The aloe extract is prepared using following methods：Clean aloe is blended, 50~60% ethanol solutions are added, The two solid-liquid ratio is 1:10~20, it extracts 3 times repeatedly, each extraction time is 50~70 minutes, merges extracting solution, after concentration To paste, the macroporous resin adsorption for being 5 through pH value after the 50% ethyl alcohol dissolving of 2~4 times of volumes of paste is purified, refined solution It can be obtained aloe extract after concentration.
The Hibiscus esculentus L. extract is prepared using following methods：Clean Golden flower is blended, 50~60% ethyl alcohol are added Solution, the two solid-liquid ratio are 1:30~40, it is extracted 4~6 hours at 85~90 DEG C, extracting solution is purified through polyamide, pure Change after liquid is concentrated and dried and can be obtained Hibiscus esculentus L. extract.
The tea polyphenols are prepared using following methods：With at least one of green tea, Pu'er tea, black tea for raw material, it is added The distilled water of 25~35 times of weight of raw material, 70~90 DEG C are impregnated 1~3 time, impregnate 15~30 minutes every time, soak is mixed, The Al for being 5.5~6.0 with pH value3++Zn2+The composite metal ion solution precipitation method are settled out tea polyphenols from soak.Al3+With Zn2+The mass ratio of the two is 1：2~3.
The preparation method of the carrot juice is：After carrot blends, the distilled water that 15~20 times of weight are added stirs evenly, It can be prepared by after 60~80 mesh filtered through gauze.
The present invention also provides a kind of preparation methods of stern protection cream for baby, include the following steps：To the formula ratio It is mixed that aloe extract, tea polyphenols, honey, carrot juice and golden sunflower extract, stirring are sequentially added in 0.9% sodium chloride solution It closes uniformly, cornstarch is added and stirs to paste, finally sequentially adds sesame oil, glycerine, sunflower oil and stirs evenly, you can system Obtain stern protection cream for baby.
Various composition is as follows in the present invention：
For the present invention using 0.9% sodium chloride solution as aqueous phase solvent, 0.9% sodium chloride solution is common drug dilution Agent, use has the function of disinfection in vitro.
Contain abundant Aloe Vera Gel in aloe extract, the penetration of Aloe Vera Gel can help skin to capture oxygen, lock Moisture, balance skin water oil, while there is clearing heat and detoxicating, anti-inflammation and sterilization, inhibit inflammation, drainage secretion, promote part new old It is metabolized, moisturizes the skin, prevent angling, the convergence open sore part, promote cytothesis, the effect of scar is reduced or avoided.
Tea polyphenols have stronger antioxidation, while having bacteriostasis, such as to staphylococcus, Escherichia coli, withered Straw bacterium etc. has inhibiting effect, can inhibit and resist virus, anti-inflammatory, beauty and skin care, anti-aging.
Contain multiple nutritional components in honey, the blood circulation of skin can be stimulated, improve nutrition condition, improves metabolism Level promotes cell growth, slows down aging, and makes elasticity and the toughness enhancing of skin, surface more Smooth and moist.Honey can also disappear It goes out bacterium, virus and other microorganisms of epidermis, there is controlling centainly to the dry and astringent of face, corrugation, furuncle, prickly heat, acne etc. Treatment acts on.
Contain abundant carrotene and cellulose A, B1, B2, C, D, E, K in carrot juice, the new old of skin can be stimulated Metabolism, promote blood circulation has the benefits of original to keep the colour of skin ruddy to skin health-care, meanwhile, vitamin A has lubricious, strong The effect of strong skin, and pachylosis can be prevented.
Contain abundant flavones and Hyperoside ingredient in golden sunflower extract, the work with anti-oxidant, anti-inflammatory, sterilization With.
Cornstarch is used as thickener in the present invention, while stern protection cream can be prevented in the surface lumps of infant skin.
Contain the substances such as distinctive sesamol, sesamolin in a certain number of vitamin Es and sesame oil in sesame oil, this The oxidation resistance of a little substances is extremely strong, while having the function of moisturizing, fluid infusion, ceases wind, removing toxic substances and eliminating sore swells.It can be used as screen Hinder injury of the agent blocking harmful weather to skin, there is moisturizing effect, is best softening agent, protecting film is provided for skin.
Glycerine can absorb the moisture in air, have the function of moisturizing, while can promote the ductility of product, increase Absorption of the skin to other compositions.
Sunflower oil contains vitamin A, B, D, E, and natural VE has antioxidation, can inhibit in human body The reason of generation of lipid peroxide and precipitation, this lipid peroxide is people's aging；The fragrant odour of sunflower oil, quality are clear Slender cause, is easily absorbed by the body, and submissive and smooth texture can be provided for skin, is suitble to all skin quality, can be used to treat ulcer of leg With skin disease, scratch, cutaneous lesions are prevented.
The present invention is by the way that aloe extract, tea polyphenols, honey, carrot juice and Jin Kui are added into 0.9% sodium chloride solution Aqueous phase substrate is made in flower extract, then the viscosity of matrix is adjusted with cornstarch, is eventually adding sesame oil, glycerine, sunflower seeds Oily oil-phase component, is made a kind of product of water-in-oil type, the product due to the interaction of each ingredient, have antibacterial anti-inflammatory, every From, maintenance, releive, the effect of moisturizing, can the buttocks skin surface of baby formed one layer of fine and close protective film, effectively prevent And treatment baby napkin dermatitis, make baby far from " red wind wind ".
Specific implementation mode
Embodiment 1
A kind of stern protection cream for baby contains following substance and weight percent：Sesame oil 20%, glycerine 10%, sunflower seeds Oil 15%, aloe extract 10%, honey 8%, cornstarch 8%, Hibiscus esculentus L. extract 1.0%, tea polyphenols 3.0%, carrot Juice 10%, 0.9% sodium chloride solution 15%.
The preparation method of above-mentioned stern protection cream for baby is：
Prepare aloe extract：Clean aloe is blended, 50% ethanol solution is added, the two solid-liquid ratio is 1：20, instead It extracts 3 times again, each extraction time is 70 minutes, merges extracting solution, obtains paste after concentration, 2 times of volumes of paste The macroporous resin adsorption for being 5 through pH value after the dissolving of 50% ethyl alcohol purifies, and eluent is 20%~60% ethanol solution, and refined solution is dense It can be obtained aloe extract after contracting.
Prepare Hibiscus esculentus L. extract：Clean Golden flower is blended, 50% ethanol solution is added, the two solid-liquid ratio is 1： 40, it is extracted 6 hours at 90 DEG C, extracting solution is purified through polyamide, extracting solution applied sample amount 50mL, sample solution concentration 4.37mg/mL, loading pH value 6.0, loading flow velocity 1.0mL/min, 5 times of column volumes of washing volume, 5 times of 80% ethyl alcohol of column volume are washed De-, elution flow rate 1.0mL/min, refined solution can be obtained Hibiscus esculentus L. extract after being concentrated and dried.
Prepare tea polyphenols：With at least one of green tea, Pu'er tea, black tea for raw material, the steaming of 35 times of weight of raw material is added Distilled water, 70 DEG C are impregnated 3 times, are impregnated 0 minute every time, and soak is mixed to the compound precipitants (10gAlCl for being added that pH is 5.83With 20gZnCl2It is dissolved in 270mL water, with 0.5mol/L NaHCO3It is the 5.8) body of soak and compound precipitants that solution, which adjusts PH, Product is than being 2：1, it is settled out tea polyphenols from soak, is extracted through ethyl acetate, extract liquor obtains tea polyphenols production after being concentrated and dried Product.
Prepare carrot juice：After carrot blends, the distilled water that 15~20 times of weight are added stirs evenly, through 60~80 mesh yarns It can be prepared by after cloth filtering.
Aloe extract, tea polyphenols, honey, carrot juice are sequentially added into 0.9% sodium chloride solution of the formula ratio It with golden sunflower extract, is uniformly mixed, cornstarch is added and stirs to paste, finally sequentially adds sesame oil, glycerine, certain herbaceous plants with big flowers Flower seed oil stirs evenly, you can stern protection cream for baby is made.
Embodiment 2
A kind of stern protection cream for baby contains following substance and weight percent：Sesame oil 20%, glycerine 8%, sunflower oil 20%, aloe extract 15%, honey 6%, cornstarch 8%, Hibiscus esculentus L. extract 1.2%, tea polyphenols 1.8%, carrot juice 5%, 0.9% sodium chloride solution 15%.
The preparation method of above-mentioned stern protection cream for baby is：
Prepare aloe extract：Clean aloe is blended, 55% ethanol solution is added, the two solid-liquid ratio is 1：15, instead It extracts 3 times again, each extraction time is 60 minutes, merges extracting solution, obtains paste after concentration, 3 times of volumes of paste The macroporous resin adsorption for being 5 through pH value after the dissolving of 50% ethyl alcohol purifies, and eluent is 20%~60% ethanol solution, and refined solution is dense It can be obtained aloe extract after contracting.
Prepare Hibiscus esculentus L. extract：Clean Golden flower is blended, 55% ethanol solution is added, the two solid-liquid ratio is 1： 35, it is extracted 5 hours at 85 DEG C, extracting solution is purified through polyamide, extracting solution applied sample amount 50mL, sample solution concentration 4.37mg/mL, loading pH value 6.0, loading flow velocity 1.0mL/min, 5 times of column volumes of washing volume, 5 times of 80% ethyl alcohol of column volume are washed De-, elution flow rate 1.0mL/min, refined solution can be obtained Hibiscus esculentus L. extract after being concentrated and dried.
Prepare tea polyphenols：With at least one of green tea, Pu'er tea, black tea for raw material, the steaming of 25 times of weight of raw material is added Distilled water, 80 DEG C are impregnated 2 times, impregnate 20 minutes every time, soak is mixed, and the compound precipitants (10gAlCl that pH is 5.8 is added3 And 20gZnCl2It is dissolved in 270mL water, with 0.5mol/L NaHCO3Solution adjust PH be 5.8), soak and compound precipitants Volume ratio is 2：1, it is settled out tea polyphenols from soak, is extracted through ethyl acetate, extract liquor obtains tea polyphenols after being concentrated and dried Product.
Prepare carrot juice：After carrot blends, the distilled water that 15~20 times of weight are added stirs evenly, through 60~80 mesh yarns It can be prepared by after cloth filtering.
Aloe extract, tea polyphenols, honey, carrot juice are sequentially added into 0.9% sodium chloride solution of the formula ratio It with golden sunflower extract, is uniformly mixed, cornstarch is added and stirs to paste, finally sequentially adds sesame oil, glycerine, certain herbaceous plants with big flowers Flower seed oil stirs evenly, you can stern protection cream for baby is made.
Embodiment 3
A kind of stern protection cream for baby contains following substance and weight percent：Sesame oil 15%, glycerine 5%, sunflower oil 20%, aloe extract 8%, honey 8%, cornstarch 8%, Hibiscus esculentus L. extract 1.2%, tea polyphenols 2.8%, carrot juice 10%, 0.9% sodium chloride solution 22%.
The preparation method of above-mentioned stern protection cream for baby is：
Prepare aloe extract：Clean aloe is blended, 60% ethanol solution is added, the two solid-liquid ratio is 1：10, instead It extracts 3 times again, each extraction time is 50 minutes, merges extracting solution, obtains paste after concentration, 4 times of volumes of paste The macroporous resin adsorption for being 5 through pH value after the dissolving of 50% ethyl alcohol purifies, and eluent is 20%~60% ethanol solution, and refined solution is dense It can be obtained aloe extract after contracting.
Prepare Hibiscus esculentus L. extract：Clean Golden flower is blended, 60% ethanol solution is added, the two solid-liquid ratio is 1： 30, it is extracted 4 hours at 90 DEG C, extracting solution is purified through polyamide, extracting solution applied sample amount 50mL, sample solution concentration 4.37mg/mL, loading pH value 6.0, loading flow velocity 1.0mL/min, 5 times of column volumes of washing volume, 5 times of 80% ethyl alcohol of column volume are washed De-, elution flow rate 1.0mL/min, refined solution can be obtained Hibiscus esculentus L. extract after being concentrated and dried.
Prepare tea polyphenols：With at least one of green tea, Pu'er tea, black tea for raw material, the steaming of 30 times of weight of raw material is added Distilled water, 90 DEG C are impregnated 2 times, impregnate 30 minutes every time, soak is mixed, and the compound precipitants (10gAlCl that pH is 5.8 is added3 And 20gZnCl2It is dissolved in 270mL water, with 0.5mol/L NaHCO3Solution adjust PH be 5.8), soak and compound precipitants Volume ratio is 2：1, it is settled out tea polyphenols from soak, is extracted through ethyl acetate, extract liquor obtains tea polyphenols after being concentrated and dried Product.
Prepare carrot juice：After carrot blends, the distilled water that 15~20 times of weight are added stirs evenly, through 60~80 mesh yarns It can be prepared by after cloth filtering.
Aloe extract, tea polyphenols, honey, carrot juice are sequentially added into 0.9% sodium chloride solution of the formula ratio It with golden sunflower extract, is uniformly mixed, cornstarch is added and stirs to paste, finally sequentially adds sesame oil, glycerine, certain herbaceous plants with big flowers Flower seed oil stirs evenly, you can stern protection cream for baby is made.
Embodiment 4
The physical and chemical index of embodiment 1,2,3 is as follows：
1, character
This stern protection cream consistency is suitable, and fine and smooth uniform, stretchability is good, odorlessness.
2, pH value inspection
This product is taken, is counted and is measured with PH, measure pH value between 6.5-7.0.
3, caloric test
Stern protection cream is packaged in transparence cosmetic bottle, in 4 DEG C of refrigerator cold-storage observations in one month without lamination.In 55 DEG C insulating box in place for 24 hours, condensation without layering, it is spoiled phenomena such as.
4, centrifugal test
Stern protection cream is packaged in 3500r/min in tool plug test tube and centrifuges 300min, no lamination.
5, it is placed at room temperature for experiment
1,2,3 made stern protection cream of embodiment is placed in bottle for cosmetics, is stored at room temperature and investigates 6 months, no lamination, Feel that unchanged, smell is unchanged after.
6, irritation test, anaphylaxis experiment
Small white mouse back cuts off hair, smears the stern protection cream that is prepared by embodiment 1,2,3 respectively in cutting plucked position, and do not have It applies position to be compared, as a result without irritation and allergic reaction.
Example 1,2,3 each 1g are applied to 2~12 months baby (totally 20 people) buttocks, observe after spending 30 minutes, do not go out Existing rubescent, dermexanthesis, foaming phenomena.
7, clinical trial result
The mountains Wannan Medical College Yi Ji pediatric hospital ward choose 100 red stern infants, children age at 2~12 months, It is randomly divided into control group and observation group, every group of 50 people, wherein men and women is fifty-fifty, and stern protection cream made from embodiment 1,2,3 exists respectively Tested on 50 red infants of observation group's stern, every time it is big after an action of the bowels, with warm water cleaning and dry, then applied with aseptic cotton carrier immediately Last layer stern protection cream；Control group is big every time only with warm water cleaning and to be dried after an action of the bowels, counts the healing of two groups of red stern infants after a week Rate, the results are shown in table below：
The Cure of the red stern infant of 1 two groups of table
Group Number of cases Red stern cures number Healing ratio
Control group 50 20 40%
Observation group 50 49 98%
Above-mentioned detailed description stern protection cream for baby and preparation method thereof carried out with reference to embodiment, be it is illustrative without It is restrictive, several embodiments can be enumerated according to limited range, therefore in the case where not departing from present general inventive concept Change and modification should belong within protection scope of the present invention.

Claims (7)

1. a kind of stern protection cream for baby, which is characterized in that contain following substance and weight percent：
Sesame oil 15 ~ 20%
Glycerine 5 ~ 10%
Sunflower oil 15 ~ 20%
Aloe extract 30 ~ 34%
Honey 6 ~ 8%
Cornstarch 6 ~ 8%
Hibiscus esculentus L. extract 0.8 ~ 1.2%
Tea polyphenols 1.5 ~ 3.0%
Carrot juice 5 ~ 10%
0.9% sodium chloride solution 10 ~ 15%.
2. stern protection cream for baby according to claim 1, which is characterized in that the aloe extract uses following methods system It is standby：Clean aloe is blended, 50 ~ 60% ethanol solutions are added, the two solid-liquid ratio is 1:10 ~ 20, it extracts 3 times, carries every time repeatedly It is 50 ~ 70 minutes to take the time, merges extracting solution, and paste is obtained after concentration, and 50% ethyl alcohol of 2 ~ 4 times of volumes of paste dissolves The macroporous resin adsorption for being 5 by p H values purifies, and can be obtained aloe extract after refined solution concentration.
3. stern protection cream for baby according to claim 1, which is characterized in that the Hibiscus esculentus L. extract uses following methods It prepares：Clean Golden flower is blended, 50 ~ 60% ethanol solutions are added, the two solid-liquid ratio is 1:30 ~ 40, it is carried at 85 ~ 90 DEG C It takes 4 ~ 6 hours, extracting solution is purified through polyamide, and refined solution can be obtained Hibiscus esculentus L. extract after being concentrated and dried.
4. stern protection cream for baby according to claim 1, which is characterized in that the tea polyphenols are prepared using following methods： With at least one of green tea, Pu'er tea, black tea for raw material, the distilled water of 25 ~ 35 times of weight of raw material is added, 70 ~ 90 DEG C are impregnated 1 It ~ 3 times, impregnates 15 ~ 30 minutes every time, soak is mixed, the Al for being 5.5 ~ 6.0 with p H values3++Zn2+Composite metal ion is molten Liquid precipitate method is settled out tea polyphenols from soak.
5. stern protection cream for baby according to claim 4, which is characterized in that Al3+And Zn2+The mass ratio of the two is 1：2~3.
6. stern protection cream for baby according to claim 1, which is characterized in that the preparation method of the carrot juice is：Hu Luo After fore-telling blends, the distilled water that 15 ~ 20 times of weight are added stirs evenly, and can be prepared by after 60 ~ 80 mesh filtered through gauze.
7. the preparation method of the stern protection cream for baby according to claim 1-6 any one, which is characterized in that the preparation Method includes the following steps：Aloe extract, tea polyphenols, bee are sequentially added into 0.9% sodium chloride solution of the formula ratio Honey, carrot juice and golden sunflower extract, are uniformly mixed, and cornstarch is added and stirs to paste, finally sequentially adds sesame Oil, glycerine, sunflower oil stir evenly, you can stern protection cream for baby is made.
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CN106389295A (en) * 2016-11-28 2017-02-15 无比滴（广东）药业有限公司 Skin soothing cream for infant
CN107550799A (en) * 2017-10-23 2018-01-09 广州元美盛化妆品有限公司 A kind of baby DHA cleanings combination
CN108567879A (en) * 2018-07-09 2018-09-25 李时珍（广州）健康科技有限公司 It is a kind of that there is the honey and aloe composition for improving children's skin problem
CN110787122A (en) * 2019-12-10 2020-02-14 武汉轻工大学 Camellia seed oil skin cream and preparation method thereof

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